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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DMB Gene

protein-coding   GIFtS: 62
GCID: GC06M032903

major histocompatibility complex, class II, DM beta
 Explore 28 diseases affiliated with
HLA-DMB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLA-DMB    

Aliases
for HLA-DMB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class II, DM Beta1 2     Class II Histocompatibility Antigen, M Beta Chain2
RING71 2 3 5     HLA Class II Histocompatibility Antigen, DM Beta Chain2
D6S221E1 2     MHC Class II Antigen HLA-DM Beta Chain2
Really Interesting New Gene 7 Protein2 3     MHC Class II HLA-DMB2
MHC Class II Antigen DMB2 3     DMB3

External Ids:    HGNC: 49351   Entrez Gene: 31092   Ensembl: ENSG000002425747   OMIM: 1428565   UniProtKB: P280683   

Export aliases for HLA-DMB gene to outside databases

Previous GC identifers: GC06M032899 GC06M032673 GC06M032949 GC06M033010 GC06Mf32973 GC06M032644


Summaries
for HLA-DMB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-DMB:
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an
alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a
central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated
invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its
gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4
encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DMB_HUMAN, P28068
Function: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from
newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides.
In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO

Gene Wiki entry for HLA-DMB


Genomic Views
for HLA-DMB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DMB gene promoter:
         TBP   SRY   AML1a   GCNF   GCNF-1   TFIID   MyoD   GCNF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-DMB promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-DMB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DMB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032903:  view genomic region     (about GC identifiers)

Start:
 32,902,406 bp from pter      End:
 32,908,847 bp from pter
Size:
 6,442 bases      Orientation:
 minus strand

6/7 alternative locations (see all 7):
Chr6-,ALT_REF_LOCI_5 32,850,680-32,857,121      Chr6-,ALT_REF_LOCI_3 32,880,346-32,898,843      Chr6-,ALT_REF_LOCI_6 32,831,136-32,873,157     
Chr6-,ALT_REF_LOCI_2 32,824,726-32,870,355      Chr6-,ALT_REF_LOCI_4 32,979,276-32,985,717      Chr6-,ALT_REF_LOCI_1 32,885,993-32,904,491     

Proteins
for HLA-DMB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DMB_HUMAN, P28068 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DM beta chain precursor  
Size: 263 amino acids; 28943 Da
Subunit: Heterodimer of an alpha chain (DMA) and a beta chain (DMB)
Subcellular location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type
I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes
5 PDB 3D structures from and Proteopedia for HLA-DMB:
1HDM (3D)        2BC4 (3D)        4FQX (3D)        4GBX (3D)        4I0P (3D)    
Secondary accessions: O77936 Q13012 Q29751 Q58ZE2 Q5SNZ8 Q5STC4 Q9XRX2

Explore the universe of human proteins at neXtProt for HLA-DMB: NX_P28068

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P28068

    • HLA-DMB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002109.2  
    ENSEMBL proteins: 
     ENSP00000390848   ENSP00000411276   ENSP00000393569   ENSP00000398890   ENSP00000391010  
    Reactome Protein details: P28068
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: HLA-DMB
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    OriGene Custom Protein Services for HLA-DMB 
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    Novus Biologicals HLA-DMB Protein
    Novus Biologicals HLA-DMB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane ----
    GO:0016021integral to membrane IEA--
    GO:0031902late endosome membrane IEA--
    GO:0042613MHC class II protein complex IEA--


    HLA-DMB for ontologies           About GeneDecksing



    HLA-DMB Antibody Products: 
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    Novus Biologicals HLA-DMB Antibodies
    Abcam antibodies for HLA-DMB 
    Browse Antibodies at Uscn
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    Assay Products for HLA-DMB: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for HLA-DMB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLA-DMB for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P28068

    ProtoNet protein and cluster: P28068

    2 Blocks protein families:
    IPB000353 Class II histocompatibility antigen
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DMB_HUMAN, P28068
    Domain: The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal
    compartments
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for HLA-DMB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DMB_HUMAN, P28068
    Function: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from
    newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides.
    In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO

         Genatlas biochemistry entry for HLA-DMB:
    HLA-DM,beta chain,class II related,expressed in B cell lysosomes,same as RING7

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HLA-DMB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DMB

    1 GenomeRNAi human phenotype for HLA-DMB:
     Decreased number of cells in m 


    Pathways & Interactions
    for HLA-DMB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Allograft rejection
    8/10 pathways (see all 10)
    		Allograft rejection1.00
    		THC Differentiation Pathway0.39
    		Type I diabetes mellitus0.67
    		CTL Mediated Apoptosis0.38
    		Graft-versus-host disease0.63
    		Intestinal immune network for IgA production0.38
    		Autoimmune thyroid disease0.60
    		Viral myocarditis0.33
    2ICos-ICosL Pathway in T-Helper Cell
    		ICos-ICosL Pathway in T-Helper Cell1.00
    		Calcium Mediated T-Cell Apoptosis0.31
    		CD28 Signaling in T-Helper Cell0.66
    3PKC-Theta Pathway
    		PKC-Theta Pathway1.00
    		ITK and TCR Signaling0.54
    		TCR Signaling0.68
    4Immune response_NFAT in immune response
    		Immune response_NFAT in immune response1.00
    		Immune response NFAT in immune response0.91
    5Immune response_ICOS pathway in T-helper cell
    		Immune response_ICOS pathway in T-helper cell1.00
    		Immune response ICOS pathway in T-helper cell0.91

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for HLA-DMB (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DMB (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HLA-DMB (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    3        Reactome Pathways for HLA-DMB
        Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    5/17         Kegg Pathways  (Kegg details for HLA-DMB) (see all 17):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus


    HLA-DMB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-DMB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for HLA-DMB (P280682, 3 ENSP000003988904) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-DMAP280672, 3, ENSP000003639764MINT-24982 I2D: score=2 STRING: ENSP00000363976
    CD74P042333, ENSP000000095304I2D: score=1 STRING: ENSP00000009530
    CD63P089623I2D: score=2 
    HLA-DRAP019033I2D: score=2 
    CD82P277013I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response IEA--
    GO:0019221cytokine-mediated signaling pathway ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--
    GO:0031295T cell costimulation ----


    HLA-DMB for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLA-DMB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-DMB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DMB
    1 Novoseek chemical compound relationship for HLA-DMB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 18.3 5 11775239 (1), 9676759 (1), 10689120 (1)

    Search CenterWatch for drugs/clinical trials and news about HLA-DMB / DMB 

    Transcripts
    for HLA-DMB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLA-DMB gene: 
    NM_002118.4  

    Unigene Cluster for HLA-DMB:

    Major histocompatibility complex, class II, DM beta
    Hs.351279  [show with all ESTs]
    Unigene Representative Sequence: NM_002118
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487996(uc003ock.2) ENST00000477537 ENST00000438510 ENST00000414017(uc010jud.2 uc010juf.2)
    ENST00000498020(uc003ocj.2) ENST00000446948 ENST00000418107(uc010jue.2 uc003ocl.2)
    ENST00000416244(uc011dql.2)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-DMB
    OriGene shRNA RFP: HLA-DMB
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB362554.1 AB362555.1 AB362556.1 AK301017.1 AY645722.1 BC027175.1 CR407606.1 U15085.1 
    Z23139.1 

    15 DOTS entries:

    DT.214633  DT.100641850  DT.92426584  DT.95282617  DT.86854291  DT.95190417  DT.95080340  DT.121352473 
    DT.121352361  DT.95170296  DT.121352647  DT.91690419  DT.92426591  DT.121352677  DT.91802735 

    24/565 AceView cDNA sequences (see all 565):

    R83739 BI821584 BE857060 AA811366 AI301001 CR591828 BF913242 H13691 
    BG755935 BC027175 CA976199 BM904240 BM818775 CA413444 N29447 AW002411 
    BG057811 CA448884 BM464610 BX115870 BI824486 R22330 CR611765 AA748710 

    GeneLoc Exon Structure


    Expression
    for HLA-DMB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DMB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCTCCAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HLA-DMB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney

    See HLA-DMB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-DMB

    SOURCE GeneReport for Unigene cluster: Hs.351279
        SABiosciences Custom PCR Arrays for HLA-DMB
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DMB

    Orthologs
    for HLA-DMB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DMB gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves B-MA21 B locus M beta chain 2 54.15(n)
    41.11(a)    		   417051  NM_001135166.1  NP_001128638.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 32(a)
    		 1 → many
    		 GL344367.1(8520-11306)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:zfos-2070c2.36
    si:busm1-160c18.36
    (see all 10)    		 si:busm1-160c18.3
    (see all 10)    		 33(a)
    25(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 8(37510422-37511403)
    8(35956336-36146143)


    ENSEMBL Gene Tree for HLA-DMB (if available)
    TreeFam Gene Tree for HLA-DMB (if available) 

    Paralogs
    for HLA-DMB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-DMB gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DOB2  HLA-DRB12  HLA-DMA2  
    HLA-DQB22  HLA-DOA2  ENSG000002489932  HLA-DQA22  HLA-DPB12  
    18/84 SIMAP similar genes for HLA-DMB using alignment to 38 protein entries:     DMB_HUMAN (see all proteins) (see all similar genes):
    HLA DQB1    DKFZp686E23209    IGHG2    HLA-DMA    HLA-DQB1*06x    HLA-DQ
    HLA-DQ-beta    HLA-D    HLA-DP    HLA-B*    IGH@    HLA-DR
    HLA-Bw62.1    HLA-Bw62.3    HLA-Bw62.4    HLA-Bw62.5    HLA-B*27    HLA

    HLA-DMB for paralogs           About GeneDecksing



    Genomic Variants
    for HLA-DMB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DMB_HUMAN, P28068
    Polymorphism: The following alleles of DMB are known: DMB*01:01, DMB*01:02, DMB*01:03, DMB*01:04 (DMB3.4), DMB*01:05,
    DMB*01:06, and DMB*01:07. The sequence shown is that of DMB*01:01


    10/209 NCBI SNPs in HLA-DMB are shown (see all 209)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs31321321,2
    		C,F,O,A,H,--32901934(+) GTATGG/AAAGAA 1 -- ds5001113Minor allele frequency- A:0.12NS EA NA PA EU CA WA CSA 7442
    rs126620771,2
    		C,F,A,H,--32902001(+) ATGAGG/AGGTCT 1 -- ds500115Minor allele frequency- A:0.08NS EA CSA WA NA 2238
    rs1165023951,2
    		F,--32902003(+) GAGGGG/TTCTGC 1 -- ds50012Minor allele frequency- T:0.04WA NA 238
    rs1877641,2
    		C,F,H,--32902114(-) ACACCG/ACCAGG 1 -- ds50018Minor allele frequency- A:0.04NS EA NA WA 776
    rs455895401,2
    		C,--32902424(+) CCAAAG/ATTTAT 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1427538511,2
    		--32902458(+) CTGTCC/TTCTAT 1 -- ut310--------
    rs107511,2
    		C,F,A,H,--32902583(-) AGCAAC/TTTGGG 1 -- ut3134Minor allele frequency- T:0.12NS EA NA MN WA CSA 3855
    rs122064261,2
    		C,F,H,--32902609(+) GAGACT/GGGGAA 1 -- ut317Minor allele frequency- G:0.02MN NS EA NA 520
    rs1136180171,2
    		--32902610(+) AGACTG/AGGAAA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1410828131,2
    		--32902628(+) AATTGA/GATGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HLA-DMB (32902406 - 32908847 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for HLA-DMB
         2 CNVs: 0076 3604
         1 Indel: 59332
    Human Gene Mutation Database (HGMD): HLA-DMB

    Locus Specific Mutation Databases (LSDB): HLA-DMB

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DMB
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DMB

    Disorders / Diseases
    for HLA-DMB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLA-DMB for disorders           About GeneDecksing

    OMIM gene information: 142856    OMIM disorders: --

    20/28 diseases for HLA-DMB (see all 28):    About MalaCards
    graft versus host disease    type 1 diabetes mellitus    severe combined immunodeficiency    lupus erythematosus
    diabetes mellitus    combined immunodeficiency    systemic lupus erythematosus    atopic dermatitis
    rheumatoid arthritis    autoimmune thyroiditis    celiac disease    dermatitis
    myopathy    toxoplasmosis    leishmaniasis    hepatitis b
    arthritis    measles    sarcoidosis    duodenitis

    4 Novoseek disease relationships for HLA-DMB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 41.2 9 10321961 (2), 9153546 (2), 10371284 (1), 9676759 (1) (see all 5)
    genetic susceptibility 40.1 1 9153546 (1)
    diabetes mellitus insulin-dependent 18 1 10519369 (1)
    lupus erythematosus systemic 9.37 3 9487257 (2), 15547089 (1)

    Genetic Association Database (GAD): HLA-DMB
    Human Genome Epidemiology (HuGE) Navigator: HLA-DMB (18 documents)

    Export disorders for HLA-DMB gene to outside databases

    Publications
    for HLA-DMB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-DMB gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with HLA-DMB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human HLA class II-related locus, DM. (PubMed id 1922365)1, 2, 3 Kelly A.P.... Trowsdale J. (1991)
    2. Association of TAP and HLA-DM genes with psoriasis in Koreans. (PubMed id 12648225)1, 4, 9 Pyo C.W....Kim T.G. (2003)
    3. Association of HLA-DM polymorphism with the production of antiphospholipid antibodies. (PubMed id 15547089)1, 4, 9 Sanchez M.L....Khamashta M.A. (2004)
    4. Polymorphisms of TAP, LMP and HLA-DM genes in the Chinese. (PubMed id 11775239)1, 4, 9 Zhu X....Wang F. (2000)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. Identification of a novel HLA-DMB allele (DMB*0107) in the Korean population. (PubMed id 15787724)1, 2 Gu H....Oh B. (2005)
    7. HLA-DMA*0103 and HLA-DMB*0104 alleles as novel prognostic factors in rheumatoid arthritis. (PubMed id 15547082)1, 4 Morel J....Combe B. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Polymorphism of HLA-DMA and DMB alleles in patients with systemic lupus erythematosus. (PubMed id 12858445)1, 4 Morel J....Eliaou J.F. (2003)
    10. Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination. (PubMed id 12786997)1, 4 Dhiman N....Poland G.A. (2003)

    External Searches for HLA-DMB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HLA-DMB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3109 HGNC: 4935 AceView: HLA-DMBandHLA-DMA Ensembl:ENSG00000242574 euGenes: HUgn3109
    ECgene: HLA-DMB Kegg: 3109 H-InvDB: HLA-DMB

    Other Databases showing HLA-DMB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLA-DMB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-DMB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HLA-DMB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-DMB gene:
    Search GeneIP for patents involving HLA-DMB

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