Aliases for HLA-DMA Gene
External Ids for HLA-DMA Gene
Previous GeneCards Identifiers for HLA-DMA Gene
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-DMA Gene
HLA-DMA (Major Histocompatibility Complex, Class II, DM Alpha) is a Protein Coding gene. Diseases associated with HLA-DMA include Rheumatoid Arthritis and Systemic Lupus Erythematosus. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and TCR Signaling (Qiagen). GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is HLA-DPA1.
UniProtKB/Swiss-Prot for HLA-DMA Gene
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.