Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HLA-C Gene

protein-coding   GIFtS: 68
GCID: GC06M031236

Major Histocompatibility Complex, Class I, C

(Previous name: psoriasis susceptibility 1)
(Previous symbols: HLA-JY3, D6S204, PSORS1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Major Histocompatibility Complex, Class I, C1 2     MHC Class I Antigen Cw*123
D6S2041 2 3     MHC Class I Antigen Cw*143
HLA-JY31 2 3     MHC Class I Antigen Cw*153
PSORS11 2 5     MHC Class I Antigen Cw*163
Psoriasis Susceptibility 11     MHC Class I Antigen Cw*173
HLC-C2     MHC Class I Antigen Cw*183
HLA Class I Histocompatibility Antigen, C Alpha Chain2     MHC Class I Antigen Cw*23
HLA Class I Histocompatibility Antigen, Cw-1 Alpha Chain2     MHC Class I Antigen Cw*33
Human Leukocyte Antigen-C Alpha Chain2     MHC Class I Antigen Cw*43
Major Histocompatibility Antigen HLA-C2     MHC Class I Antigen Cw*53
MHC Class I Antigen Heavy Chain HLA-C2     MHC Class I Antigen Cw*63
HLAC3     MHC Class I Antigen Cw*73
MHC Class I Antigen Cw*13     MHC Class I Antigen Cw*83

External Ids:    HGNC: 49331   Entrez Gene: 31072   Ensembl: ENSG000002045257   OMIM: 1428405   UniProtKB: P304993   
UniProtKB: P305013   UniProtKB: P042223   UniProtKB: P305043   UniProtKB: Q9TNN73   UniProtKB: Q299633   
UniProtKB: P103213   UniProtKB: P305053   UniProtKB: P305083   UniProtKB: P305103   UniProtKB: Q070003   
UniProtKB: Q299603   UniProtKB: Q956043   UniProtKB: Q298653   
ORGUL members:         

Export aliases for HLA-C gene to outside databases

Previous GC identifers: GC06M031290 GC06M031007 GC06M031341 GC06M031344


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HLA-C Gene:
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a
heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I
molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum
lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8
exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind
the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode
the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity
of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney
transplantation. Over one hundred HLA-C alleles have been described (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-C Gene:
HLA-C (major histocompatibility complex, class I, C) is a protein-coding gene. Diseases associated with HLA-C include hiv-1 viremia, and psoriasis susceptibility 1. GO annotations related to this gene include peptide antigen binding and receptor binding. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: 1C01_HUMAN, P30499 (see all)
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NT_113891.3  NC_000006.12  NC_018917.2  NT_007592.16  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-C gene promoter:
         USF1   AP-1   ATF-2   CUTL1   AP-2gamma   POU2F1   USF-1   ARP-1   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-C promoter sequence
   Search Chromatin IP Primers for HLA-C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HLA-C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031236:  view genomic region     (about GC identifiers)

Start:
31,236,526 bp from pter      End:
31,239,907 bp from pter
Size:
3,382 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167246 2,583,424-2,586,739      Chr6-,NT_113891.2 2,749,781-2,753,156      Chr6-,NT_167249 2,570,008-2,573,323     
Chr6-,NT_167247 2,617,066-2,620,381      Chr6-,NT_167245 2,532,137-2,535,452      Chr6-,NT_167248 2,529,780-2,533,095     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: 1C01_HUMAN, P30499 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, Cw-1 alpha chain precursor  
Size: 366 amino acids; 40965 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02865 O19676 P30500 Q29986 Q9UQS9

UniProtKB/Swiss-Prot: 1C02_HUMAN, P30501 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-2 alpha chain precursor  
Size: 366 amino acids; 41095 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: P30502

UniProtKB/Swiss-Prot: 1C03_HUMAN, P04222 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-3 alpha chain precursor  
Size: 366 amino acids; 40861 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
1 PDB 3D structure from and Proteopedia for HLA-C:
1EFX (3D)    
Secondary accessions: O62883 O78060 O78068 O78069 P30503 Q29743 Q29992 Q29993 Q9GIK8 Q9TQB4

UniProtKB/Swiss-Prot: 1C04_HUMAN, P30504 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-4 alpha chain precursor  
Size: 366 amino acids; 40995 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity). Interacts with HTLV-1 p12I accessory protein
2 PDB 3D structures from and Proteopedia for HLA-C:
1IM9 (3D)        1QQD (3D)    
Secondary accessions: O78067 O78072 O78090 O78149 Q29921 Q9UM42

UniProtKB/Swiss-Prot: 1C05_HUMAN, Q9TNN7 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-5 alpha chain precursor  
Size: 366 amino acids; 40912 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02866 O62888 Q9TPV8 Q9TPX2

UniProtKB/Swiss-Prot: 1C06_HUMAN, Q29963 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-6 alpha chain precursor  
Size: 366 amino acids; 40969 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19505 O78063 Q29989

UniProtKB/Swiss-Prot: 1C07_HUMAN, P10321 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor  
Size: 366 amino acids; 40649 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
1 PDB 3D structure from and Proteopedia for HLA-C:
3BZF (3D)    
Secondary accessions: O78061 O78083 Q29631 Q29652 Q29867 Q29990 Q95463 Q95603 Q9MY31 Q9TQP9

UniProtKB/Swiss-Prot: 1C08_HUMAN, P30505 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-8 alpha chain precursor  
Size: 366 amino acids; 40773 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: P30506 P30507

UniProtKB/Swiss-Prot: 1C12_HUMAN, P30508 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-12 alpha chain precursor  
Size: 366 amino acids; 40886 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02863 O19652 O62882 O78062 O78166 O78211 O78214 P30509 Q29768 Q31627
Q860R1 Q860R2 Q99528 Q9GIK4 Q9TPS4 Q9UM32 Q9UM33

UniProtKB/Swiss-Prot: 1C14_HUMAN, P30510 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-14 alpha chain precursor  
Size: 366 amino acids; 40838 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O62879 O78178 Q29641 Q30192 Q9MY35 Q9TQJ5

UniProtKB/Swiss-Prot: 1C15_HUMAN, Q07000 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-15 alpha chain precursor  
Size: 366 amino acids; 40863 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O78165 Q29864 Q29991 Q31605 Q9BD28 Q9GJ33 Q9MY49

UniProtKB/Swiss-Prot: 1C16_HUMAN, Q29960 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-16 alpha chain precursor  
Size: 366 amino acids; 40753 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O78091 O78202 Q29862 Q29959 Q9MY74 Q9MYI3 Q9TNZ8
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

UniProtKB/Swiss-Prot: 1C17_HUMAN, Q95604 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-17 alpha chain precursor  
Size: 372 amino acids; 41238 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02864 O02958 Q29643 Q9MY30
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

UniProtKB/Swiss-Prot: 1C18_HUMAN, Q29865 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-18 alpha chain precursor  
Size: 366 amino acids; 40933 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O78203 P79498
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

Explore the universe of human proteins at neXtProt for HLA-C: NX_Q29865

Explore proteomics data for HLA-C at MOPED

Post-translational modifications: 

  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the
    protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets
    the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Ubiquitination2 at Lys145, Lys200, Lys210, Lys267
  • Glycosylation2 at Asn110
  • Modification sites at PhosphoSitePlus

  • See HLA-C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229971.1  NP_002108.4  

    ENSEMBL proteins: 
     ENSP00000365402   ENSP00000372819   ENSP00000365412   ENSP00000400410  
    Reactome Protein details: Q95604 P30499 Q07000 P30508 Q9TNN7 P30501 P30510 P30504 Q29963 P30505 Q29865 P10321 Q29960 P04222

    HLA-C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HLA-C
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HLA-C
    GenScript Custom Purified and Recombinant Proteins Services for HLA-C
    Novus Biologicals HLA-C Protein
    Novus Biologicals HLA-C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HLA-C
    Browse Proteins at Cloud-Clone Corp.

    HLA-C Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-C
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HLA-C
    OriGene Custom Antibody Services for HLA-C
    Novus Biologicals HLA-C Antibodies
    Abcam antibodies for HLA-C (P30499, Q07000, P10321, P01889, P04222)
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for HLA-C
    LSBio Antibodies in human, mouse, rat for HLA-C

    HLA-C Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-C
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P30499
    Graphical View of Domain Structure for InterPro Entry P30501
    Graphical View of Domain Structure for InterPro Entry P04222
    Graphical View of Domain Structure for InterPro Entry P30504
    Graphical View of Domain Structure for InterPro Entry Q9TNN7
    Graphical View of Domain Structure for InterPro Entry Q29963
    Graphical View of Domain Structure for InterPro Entry P10321
    Graphical View of Domain Structure for InterPro Entry P30505
    Graphical View of Domain Structure for InterPro Entry P30508
    Graphical View of Domain Structure for InterPro Entry P30510
    Graphical View of Domain Structure for InterPro Entry Q07000
    Graphical View of Domain Structure for InterPro Entry Q29960
    Graphical View of Domain Structure for InterPro Entry Q95604
    Graphical View of Domain Structure for InterPro Entry Q29865

    ProtoNet protein and cluster: P30499

    3 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1C01_HUMAN, P30499
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C02_HUMAN, P30501
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C03_HUMAN, P04222
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C04_HUMAN, P30504
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C05_HUMAN, Q9TNN7
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C06_HUMAN, Q29963
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C07_HUMAN, P10321
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C08_HUMAN, P30505
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C12_HUMAN, P30508
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C14_HUMAN, P30510
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C15_HUMAN, Q07000
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C16_HUMAN, Q29960
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C17_HUMAN, Q95604
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C18_HUMAN, Q29865
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 1C01_HUMAN, P30499 (see all)
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-C:
    HLA-C,alpha chain,44kDa,class Ia (see MHC1)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IBA--
    GO:0005515protein binding ----
    GO:0042605peptide antigen binding ISS--
    GO:0046977TAP binding IDA8617941
         
    HLA-C for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-C

    miRNA
    Products:
        
    miRTarBase miRNAs that target HLA-C:
    hsa-mir-484 (MIRT041720), hsa-let-7e-5p (MIRT051644), hsa-mir-423-3p (MIRT042611)

    Block miRNA regulation of human, mouse, rat HLA-C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HLA-C
    SwitchGear 3'UTR luciferase reporter plasmidHLA-C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-C
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-C

    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-C (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-C (NM_002117)
    Sino Biological Human cDNA Clone for HLA-C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-C

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLA-C
    Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    1C01_HUMAN, P30499: Membrane; Single-pass type I membrane protein
    1C02_HUMAN, P30501: Membrane; Single-pass type I membrane protein
    1C03_HUMAN, P04222: Membrane; Single-pass type I membrane protein
    1C04_HUMAN, P30504: Membrane; Single-pass type I membrane protein
    1C05_HUMAN, Q9TNN7: Membrane; Single-pass type I membrane protein
    1C06_HUMAN, Q29963: Membrane; Single-pass type I membrane protein
    1C07_HUMAN, P10321: Membrane; Single-pass type I membrane protein
    1C08_HUMAN, P30505: Membrane; Single-pass type I membrane protein
    1C12_HUMAN, P30508: Membrane; Single-pass type I membrane protein
    1C14_HUMAN, P30510: Membrane; Single-pass type I membrane protein
    1C15_HUMAN, Q07000: Membrane; Single-pass type I membrane protein
    1C16_HUMAN, Q29960: Isoform 1: Cell membrane; Single-pass type I membrane protein
    1C16_HUMAN, Q29960: Isoform 2: Secreted
    1C17_HUMAN, Q95604: Membrane; Single-pass type I membrane protein
    1C18_HUMAN, Q29865: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    plasma membrane4
    cytoskeleton2
    extracellular2
    nucleus2
    vacuole2
    cytosol1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS1384166
    GO:0009986cell surface ISS--

    HLA-C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HLA-C About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Proteasome Degradation0.57
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    Immune response Antigen presentation by MHC class I0.68
    3Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-C
        CDC42 Pathway
    CTL Mediated Apoptosis

    2 GeneGo (Thomson Reuters) Pathways for HLA-C
        Immune response Antigen presentation by MHC class I
    Immune response Role of DAP12 receptors in NK cells

    2 BioSystems Pathways for HLA-C
        Allograft Rejection
    Proteasome Degradation

    1 Sino Biological Pathway for HLA-C
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for HLA-C (see all 7)
        Endosomal/Vacuolar pathway
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    DAP12 interactions


    Selected Kegg Pathways  (Kegg details for HLA-C) (see all 14):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    HLA-C for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HLA-C
    Interactions:

        GeneGlobe Interaction Network for HLA-C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HLA-C (Q070002, 3 ENSP000003654024 P305042, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617692, ENSP000003408584MINT-24804 STRING: ENSP00000340858
    KIR2DL1ENSP000003367694STRING: ENSP00000336769
    KIR2DL3ENSP000003422154STRING: ENSP00000342215
    CD8AENSP000002836354STRING: ENSP00000283635
    KIR3DS1ENSP000003836454STRING: ENSP00000383645
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0002486antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IDA--

    HLA-C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-C (1C18)

    1 PharmGKB related drug/compound annotation for HLA-C gene    About this table
    Drug/compound PharmGKB Annotation
    nevirapineCA  



    HLA-C for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HLA-C gene (2 alternative transcripts): 
    NM_001243042.1  NM_002117.5  

    Unigene Cluster for HLA-C:

    Major histocompatibility complex, class I, C
    Hs.656020  [show with all ESTs]
    Unigene Representative Sequence: NR_027822
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466892 ENST00000470363 ENST00000487245(uc011dnj.2) ENST00000376228
    ENST00000383329(uc021yuk.1) ENST00000376237(uc003nsy.3 uc011dnl.2)
    ENST00000415537 ENST00000495835 ENST00000484378
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HLA-C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HLA-C
    SwitchGear 3'UTR luciferase reporter plasmidHLA-C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HLA-C
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-C
    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-C (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-C (NM_002117)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-C
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-C
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-C
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HLA-C
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-C
      QuantiFast Probe-based Assays in human, mouse, rat HLA-C

    Additional mRNA sequence: 

    AK127349.1 BC139904.1 BC141846.1 NR_027822.1 S74115.1 

    22 DOTS entries:

    DT.100814392  DT.91783947  DT.91787286  DT.92416064  DT.95331860  DT.121346289  DT.40281316  DT.87018278 
    DT.100039972  DT.100647400  DT.100647401  DT.100849442  DT.100867020  DT.121310253  DT.121346430  DT.87013992 
    DT.91673977  DT.91804685  DT.92411950  DT.95331704  DT.95331815  DT.97870100 

    Selected AceView cDNA sequences (see all 251):

    BM917107 AL553833 BI906452 BQ719235 BQ892338 CN480960 BX459241 BQ720232 
    AW401719 BI912419 BM918142 BM561565 CD620604 BM148269 AW239462 BX378406 
    AL537877 BG744129 BQ716678 AW402264 BG898693 CB127943 BQ720157 CB151614 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HLA-C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAGTGTG
    HLA-C Expression
    About this image


    HLA-C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical tissue-derived cells (CNTO2476)
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Adipose-derived mesenchymal stem cells (family)
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Mesenchymal Stem Cells
             Adipose-derived mesenchymal stem cells (family)
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
    HLA-C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656020
        Custom PCR Arrays for HLA-C
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-C
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-C
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HLA-C
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-C
    QuantiFast Probe-based Assays in human, mouse, rat HLA-C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and chimp.

    Orthologs for HLA-C gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia PATR-C1 major histocompatibility complex, class I, C 95.99(n)
    92.35(a)
      471962  NM_001012439.2  NP_001012441.2 


    ENSEMBL Gene Tree for HLA-C (if available)
    TreeFam Gene Tree for HLA-C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HLA-C gene
    HLA-F2  FCGRT2  HLA-E2  HLA-A2  MR12  HLA-B2  HFE2  AZGP12  
    HLA-G2  
    Selected SIMAP similar genes for HLA-C using alignment to 4897 protein entries:     1C01_HUMAN (see all proteins) (see all similar genes):
    MHC class I    Cw*08    HLA-DRB1*1605    HLA-DRB14    HLA-Cw3    HLA-DR beta
    HLA-DRB1*1327    MHC class II HLA-DRB1 Exon-2    HLA-A*0201V3    HLA-Cw*15P    Cw    HLA-Cw*02023
    HLAC    HLA-Cw*0707    HLA-Cw*07    MHC    HLA-Cw*    HLA-Cw*03MAC

    HLA-C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    1C01_HUMAN, P30499: The following alleles of Cw-1 are known: Cw*01:01 (Cw1.1), Cw*01:02 (Cw1.2), Cw*01:03 and Cw*01:04.
    The sequence shown is that of Cw*01:01
    1C02_HUMAN, P30501: The following alleles of Cw-2 are known: Cw*02:01 (Cw2.1) and Cw*02:02 (Cw2.2). The sequence shown
    is that of Cw*02:01
    1C03_HUMAN, P04222: The following alleles of Cw-3 are known: Cw*03:02 (Cw3.2), Cw*03:03, Cw*03:04 (Cw3.1), Cw*03:05,
    Cw*03:06, Cw*03:07, Cw*03:08, Cw*03:09 and Cw*03:13. The sequence shown is that of Cw*03:04
    1C04_HUMAN, P30504: The following alleles of Cw-4 are known: Cw*04:01 Cw*04:03, Cw*04:04, Cw*04:05 and Cw*04:06. The
    sequence shown is that of Cw*04:01
    1C05_HUMAN, Q9TNN7: The following alleles of Cw-5 are known: Cw*05:01 Cw*0502, Cw*05:03 and Cw*05:04. The sequence shown
    is that of Cw*05:01
    1C06_HUMAN, Q29963: The following alleles of Cw-6 are known: Cw*06:02 Cw*06:03 and Cw*06:04. Allele Cw*062 is a risk
    factor that confers susceptibility to psoriasis. The sequence shown is that of Cw*06:02
    1C07_HUMAN, P10321: The following alleles of Cw-7 are known: Cw*07:01, Cw*07:02, Cw*07:03, Cw*07:04, Cw*07:06, Cw*07:09
    and Cw*07:11. The sequence shown is that of Cw*07:02
    1C08_HUMAN, P30505: The following alleles of Cw-8 are known: Cw*08:01 (Cw8.1), Cw*08:02 (Cw8.2) and Cw*08:03. The
    sequence shown is that of Cw*08:01
    1C12_HUMAN, P30508: The following alleles of Cw-12 are known: Cw*12:02, Cw*12:03, Cw*12:04, Cw*12:05, Cw*12:06,
    Cw*12:07, Cw*12:08 and Cw*12:09. The sequence shown is that of Cw*12:02
    1C14_HUMAN, P30510: The following alleles of Cw-14 are known: Cw*14:02 (CB-1), Cw*14:03 (CX44) and Cw*14:04. The
    sequence shown is that of Cw*14:02
    1C15_HUMAN, Q07000: The following alleles of Cw-15 are known: Cw*15:02, Cw*15:03, Cw*15:04, Cw*15:05, Cw*15:10 and
    Cw*15:11. The sequence shown is that of Cw*15:02
    1C16_HUMAN, Q29960: The following alleles of Cw-16 are known: Cw*16:01, Cw*16:02 (CW*CL10V) and Cw*16:04. The sequence
    shown is that of Cw*16:01
    1C17_HUMAN, Q95604: Cw*17 appears at low frequencies in Caucasoid and Mongoloid populations (gene frequency 0.41 % in
    English Caucasoids, 0% in Japanese), but seems to be a common specificity in populations of African origin
    (PubMed:9098935). The following alleles of Cw-17 are known: Cw*17:01, Cw*17:02 and Cw*17:03. The sequence shown
    is that of Cw*17:01
    1C18_HUMAN, Q29865: The following alleles of Cw-18 are known: Cw*18:01 (Cw*04GB) and Cw*18:02 (Cw*18GB). The sequence
    shown is that of Cw*18:01


    Selected SNPs for HLA-C (see all 1163)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162291441,2
    C,Fhistocompatibility131236800(+) GGGTGG/AGCTGT 2 -- ut312Minor allele frequency- A:0.04WA EU 705
    rs10496501,2
    C,Fhistocompatibility131236808(-) GTGGAG/CAGACA 2 -- ut317Minor allele frequency- C:0.07MN NA CSA WA EA EU 1138
    rs10496631,2
    C,Fhistocompatibility131236813(-) AGGAGG/TTGGAG 2 -- ut313Minor allele frequency- T:0.03WA EU 713
    rs10496681,2
    C,Fhistocompatibility131236821(-) ATAATG/ATGAGG 2 -- ut313Minor allele frequency- A:0.03WA EU 713
    rs412890691,2
    C,Fhistocompatibility131236836(+) ACAGGA/GACGCA 2 -- ut312Minor allele frequency- G:0.03CSA EU 409
    rs31760071,2
    C,Fhistocompatibility131236845(-) GAATGT/CGTCTG 2 -- ut31 ese34Minor allele frequency- C:0.05MN WA NA EU 1015
    rs10657111,2
    C,Fhistocompatibility131236853(-) AGGCAT/CCTGAA 1 -- ut31 ese39Minor allele frequency- C:0.21MN NA WA CSA EU 632
    rs10497091,2
    C,Fhistocompatibility131236854(-) AAGGCA/GCCTGA 1 -- ut31 ese33Minor allele frequency- G:0.14NA MN EU 777
    rs10497241,2
    C,Fhistocompatibility131236862(-) TTTCTG/ACAAAG 2 -- ut313Minor allele frequency- A:0.05WA CSA EU 597
    rs10498531,2
    C,F,Hhistocompatibility131236900(-) CACCTC/TTCCTT 2 -- ut31 ese3 trp328Minor allele frequency- T:0.11NS EA NA MN WA EU 4579

    HapMap Linkage Disequilibrium report for HLA-C (31236526 - 31239907 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-C (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1094e199CNV Deletion23128226
    esv2503823CNV Deletion19546169
    dgv1093e199CNV Deletion23128226
    esv2422229CNV Deletion17116639
    dgv1043e201CNV Deletion23290073
    dgv1042e201CNV Deletion23290073
    esv2731791CNV Deletion23290073
    esv2946CNV Duplication18987735
    esv25563CNV Loss19812545
    dgv103e19CNV Loss19470904

    Human Gene Mutation Database (HGMD): HLA-C
    Locus Specific Mutation Databases (LSDB): HLA-C

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-C
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 142840   
    OMIM disorders: 177900  609423  
    UniProtKB/Swiss-Prot: 1C18_HUMAN, Q29865
  • Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial
    etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions
    are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and
    epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for HLA-C (see all 162):    
    About MalaCards
    hiv-1 viremia    psoriasis susceptibility 1    guttate psoriasis    sympathetic ophthalmia
    pityriasis rosea    birdshot chorioretinopathy    alveolar echinococcosis    paraneoplastic pemphigus
    cholangitis    coronary artery aneurysm    htlv-1 associated myelopathy    peyronie's disease
    peyronies disease    neuromyelitis optica    echinococcosis    syphilis
    psoriasis    psoriatic arthritis    autoimmune pancreatitis    multinodular goiter

    Selected diseases from the University of Copenhagen DISEASES database for HLA-C (see all 24):
    Hypersensitivity reaction type II disease     Leukemia     Psoriasis     Diabetes mellitus
    Ankylosing spondylitis     Arthritis     Multiple sclerosis     Melanoma
    Uveitis     Liver disease     Bone marrow disease     Lung disease
    Stevens-Johnson syndrome     Hyperthyroidism     Anemia     Psoriatic arthritis
    Vascular disease     Human immunodeficiency virus infectious disease     Lymphoma     Connective tissue disease

    HLA-C for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HLA-C gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 65.8 24 10773694 (3), 10545595 (3), 17666781 (2), 10888604 (2) (see all 12)
    behcet disease 43.7 9 8872174 (3), 8896070 (1)
    skin diseases 43.3 1 10888604 (1)
    arthritis psoriatic 38.5 6 15539411 (2), 16313304 (2), 20476959 (1)
    miscarriage 29.4 1 1471708 (1)
    cholangitis primary sclerosing 26.4 2 9731555 (2)
    hepatitis c 7.61 2 16571411 (1), 20456039 (1)
    leukemia 0 2 10366797 (1), 10715516 (1)
    aids 0 2 19115949 (1)
    tumors 0 3 9788622 (1), 12714638 (1), 17023986 (1)

    Genetic Association Database (GAD): HLA-C
    Human Genome Epidemiology (HuGE) Navigator: HLA-C (2858 documents)

    Export disorders for HLA-C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HLA-C gene, integrated from 10 sources (see all 886):
    (articles sorted by number of sources associating them with HLA-C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. (PubMed id 16642438)1, 3, 4 Nair R.P.... Elder J.T. (Am. J. Hum. Genet. 2006)
    2. Donor HLA-C genotype has a profound impact on the clinical outcome following liver transplantation. (PubMed id 18671674)1, 4, 9 Hanvesakul R....Briggs D. (Am. J. Transplant. 2008)
    3. Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain. (PubMed id 16490887)1, 4, 9 RA-os A....Parrilla P. (Arch Surg 2006)
    4. Study of alanine-73 and aspartate-9 of HLA-C locus in Saudi psoriasis patients, using sequence-specific primers (PCR-SSP). (PubMed id 15943912)1, 4, 9 Abanmi A....Tariq M. (J. Biochem. Mol. Biol. 2005)
    5. HLA-C locus alleles distribution in patients from northern Poland with psoriatic arthritis--preliminary report. (PubMed id 16313304)1, 4, 9 Szczerkowska Dobosz A....Nedoszytko B. (Int. J. Immunogenet. 2005)
    6. Natural killer cell receptor and HLA-C gene polymorphisms among patients with hepatitis C: a comparison between sustained virological responders and non-responders. (PubMed id 20456039)1, 4, 9 Carneiro V.L....Lyra A.C. (Liver Int. 2010)
    7. A second major histocompatibility complex susceptibility locus for multiple sclerosis. (PubMed id 17252545)1, 4, 9 Yeo T.W....Sawcer S. (Ann. Neurol. 2007)
    8. Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort. (PubMed id 15539411)1, 4, 9 Lascorz J....Reis A. (Ann. Rheum. Dis. 2005)
    9. HLA-C and KIR genes in hepatitis C virus infection. (PubMed id 16571411)1, 4, 9 Montes-Cano M.A....GonzA!lez-Escribano M.F. (Hum. Immunol. 2005)
    10. Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus. (PubMed id 20077564)1, 4, 9 Knapp S....Khakoo S.I. (Hepatology 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3107 HGNC: 4933 AceView: HLA-C.1 Ensembl:ENSG00000204525 euGenes: HUgn3107
    ECgene: HLA-C Kegg: 3107 H-InvDB: HLA-C

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HLA-C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HLA-C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HLA-C gene:
    Search GeneIP for patents involving HLA-C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-C
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HLA-C   OriGene RNAi products in human, mouse, rat for HLA-C  
     OriGene qPCR primer pairs and template standards for HLA-C   OriGene Protein Over-expression Lysate for HLA-C  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HLA-C  
     OriGene qSTAR qPCR primer pairs in human, mouse for HLA-C   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HLA-C   OriGene Custom Protein Services for HLA-C  

     
     
     Block miRNA regulation of human, mouse, rat HLA-C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HLA-C
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-C Predesigned siRNA for gene silencing in human, mouse, rat HLA-C
     QuantiFast Probe-based Assays in human, mouse, rat HLA-C QuantiTect SYBR Green Assays in human, mouse, rat HLA-C
     Custom PCR Arrays for HLA-C Search Chromatin IP Primers for HLA-C
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HLA-C  GeneGlobe Interaction Network for HLA-C
     Regulatory tfbs in HLA-C promoter
     GenScript Custom Purified and Recombinant Proteins Services for HLA-C GenScript cDNA clones with any tag delivered in your preferred vector for HLA-C
     GenScript Custom Assay Services for HLA-C GenScript Custom overexpressing Cell Line Services for HLA-C
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HLA-C (1C18)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HLA-C
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HLA-C antibodies
     HLA-C proteins
     HLA-C lysates
     Antibodies for HLA-C
     See all of Abcam's Antibodies, Kits and Proteins for HLA-C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HLA-C
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-C
     SwitchGear 3'UTR luciferase reporter plasmids for HLA-C
     SwitchGear Promoter luciferase reporter plasmids for HLA-C
     Search ThermoFisher Antibodies for HLA-C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-C
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-C
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-C
     LSBio Antibodies in human, mouse, rat for HLA-C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HLA-C gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4