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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-C Gene

protein-coding   GIFtS: 64
GCID: GC06M031236

major histocompatibility complex, class I, C


(Previous symbols: HLA-JY3, D6S204)
 Explore 157 diseases affiliated with
HLA-C via
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Biological research products
for HLA-C    

Aliases
for HLA-C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class I, C1 2     MHC Class I Antigen Cw*143
D6S2041 2 3     MHC Class I Antigen Cw*153
HLA-JY31 2 3     MHC Class I Antigen Cw*163
PSORS12 5     MHC Class I Antigen Cw*173
HLC-C2     MHC Class I Antigen Cw*183
HLA Class I Histocompatibility Antigen, C Alpha Chain2     MHC Class I Antigen Cw*23
HLA Class I Histocompatibility Antigen, Cw-1 Alpha Chain2     MHC Class I Antigen Cw*33
Human Leukocyte Antigen-C Alpha Chain2     MHC Class I Antigen Cw*43
Major Histocompatibility Antigen HLA-C2     MHC Class I Antigen Cw*53
MHC Class I Antigen Heavy Chain HLA-C2     MHC Class I Antigen Cw*63
HLAC3     MHC Class I Antigen Cw*73
MHC Class I Antigen Cw*13     MHC Class I Antigen Cw*83
MHC Class I Antigen Cw*123     

External Ids:    HGNC: 49331   Entrez Gene: 31072   Ensembl: ENSG000002045257   OMIM: 1428405   UniProtKB: P304993   
UniProtKB: P305013   UniProtKB: P042223   UniProtKB: P305043   UniProtKB: Q9TNN73   UniProtKB: Q299633   
UniProtKB: P103213   UniProtKB: P305053   UniProtKB: P305083   UniProtKB: P305103   UniProtKB: Q070003   
UniProtKB: Q299603   UniProtKB: Q956043   UniProtKB: Q298653   

Export aliases for HLA-C gene to outside databases

Previous GC identifers: GC06M031290 GC06M031007 GC06M031341 GC06M031344


Summaries
for HLA-C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-C:
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy
chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a
central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed
in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the
leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the
alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms
within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for
these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have
been described (provided by RefSeq, Jul 2008)

UniProtKB/ace: 1C01_HUMAN, P30499 (see all)
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-C


Genomic Views
for HLA-C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_018917.1  NT_113891.2  NC_000006.11  NT_007592.15  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-C gene promoter:
         USF1   AP-1   ATF-2   CUTL1   AP-2gamma   POU2F1   USF-1   ARP-1   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-C promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HLA-C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031236:  view genomic region     (about GC identifiers)

Start:
 31,236,526 bp from pter      End:
 31,239,907 bp from pter
Size:
 3,382 bases      Orientation:
 minus strand

3 alternative locations:
Chr6-,ALT_REF_LOCI_4 31,203,083-31,206,399      Chr6-,ALT_REF_LOCI_2 31,227,577-31,270,094      Chr6-,ALT_REF_LOCI_5 31,228,489-31,231,805     

Proteins
for HLA-C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 1C01_HUMAN, P30499 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, Cw-1 alpha chain precursor  
Size: 366 amino acids; 40965 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02865 O19676 P30500 Q29986 Q9UQS9

UniProtKB/Swiss-Prot: 1C02_HUMAN, P30501 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-2 alpha chain precursor  
Size: 366 amino acids; 41095 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: P30502

UniProtKB/Swiss-Prot: 1C03_HUMAN, P04222 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-3 alpha chain precursor  
Size: 366 amino acids; 40861 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for HLA-C:
1EFX (3D)    
Secondary accessions: O62883 O78060 O78068 O78069 P30503 Q29743 Q29992 Q29993 Q9GIK8 Q9TQB4

UniProtKB/Swiss-Prot: 1C04_HUMAN, P30504 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-4 alpha chain precursor  
Size: 366 amino acids; 40995 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity). Interacts with HTLV-1 p12I accessory protein
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for HLA-C:
1IM9 (3D)        1QQD (3D)    
Secondary accessions: O78067 O78072 O78090 O78149 Q29921 Q9UM42

UniProtKB/Swiss-Prot: 1C05_HUMAN, Q9TNN7 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-5 alpha chain precursor  
Size: 366 amino acids; 40912 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02866 O62888 Q9TPV8 Q9TPX2

UniProtKB/Swiss-Prot: 1C06_HUMAN, Q29963 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-6 alpha chain precursor  
Size: 366 amino acids; 40969 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19505 O78063 Q29989

UniProtKB/Swiss-Prot: 1C07_HUMAN, P10321 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor  
Size: 366 amino acids; 40649 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for HLA-C:
3BZF (3D)    
Secondary accessions: O78061 O78083 Q29631 Q29652 Q29867 Q29990 Q95463 Q95603 Q9MY31 Q9TQP9

UniProtKB/Swiss-Prot: 1C08_HUMAN, P30505 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-8 alpha chain precursor  
Size: 366 amino acids; 40773 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: P30506 P30507

UniProtKB/Swiss-Prot: 1C12_HUMAN, P30508 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-12 alpha chain precursor  
Size: 366 amino acids; 40886 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02863 O19652 O62882 O78062 O78166 O78211 O78214 P30509 Q29768 Q31627 Q860R1
Q860R2 Q99528 Q9GIK4 Q9TPS4 Q9UM32 Q9UM33

UniProtKB/Swiss-Prot: 1C14_HUMAN, P30510 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-14 alpha chain precursor  
Size: 366 amino acids; 40838 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O62879 O78178 Q29641 Q30192 Q9MY35 Q9TQJ5

UniProtKB/Swiss-Prot: 1C15_HUMAN, Q07000 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-15 alpha chain precursor  
Size: 366 amino acids; 40863 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O78165 Q29864 Q29991 Q31605 Q9BD28 Q9GJ33 Q9MY49

UniProtKB/Swiss-Prot: 1C16_HUMAN, Q29960 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-16 alpha chain precursor  
Size: 366 amino acids; 40753 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Secondary accessions: O78091 O78202 Q29862 Q29959 Q9MY74 Q9MYI3 Q9TNZ8
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

UniProtKB/Swiss-Prot: 1C17_HUMAN, Q95604 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-17 alpha chain precursor  
Size: 372 amino acids; 41238 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02864 O02958 Q29643 Q9MY30
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

UniProtKB/Swiss-Prot: 1C18_HUMAN, Q29865 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-18 alpha chain precursor  
Size: 366 amino acids; 40933 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O78203 P79498
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

Explore the universe of human proteins at neXtProt for HLA-C: NX_Q29865

Post-translational modifications:

  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the
    • protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the
    • protein for rapid degradation via the ubiquitin system (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q29865

    • HLA-C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229971.1  NP_002108.4  

    ENSEMBL proteins: 
     ENSP00000365402   ENSP00000372819   ENSP00000379553   ENSP00000365412   ENSP00000400410  
     ENSP00000440406  
    Reactome Protein details: Q95604 P30499 Q07000 P30508 Q9TNN7 P30501 P30510 P30504 Q29963 P30505 Q29865 P10321 Q29960 P04222
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HLA-C
    OriGene Custom Protein Services for HLA-C 
    GenScript Custom Purified and Recombinant Proteins Services for HLA-C
    Novus Biologicals HLA-C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HLA-C

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS1384166
    GO:0012507ER to Golgi transport vesicle membrane TAS--


    HLA-C for ontologies           About GeneDecksing



    HLA-C Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-C
    Browse R&D Systems for Antibodies
    OriGene Antibodies: HLA-C
    OriGene Custom Antibody Services for HLA-C 
    GenScript Custom Superior Antibodies Services for HLA-C
    Novus Biologicals HLA-C Antibodies
    Abcam antibodies for HLA-C 
    Uscn Antibodies for HLA-C
    Search ThermoFisher Antibodies for HLA-C

    Assay Products for HLA-C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HLA-C

    Protein Domains /
    Families
    for HLA-C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLA-C for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P30499
    Graphical View of Domain Structure for InterPro Entry P30501
    Graphical View of Domain Structure for InterPro Entry P04222
    Graphical View of Domain Structure for InterPro Entry P30504
    Graphical View of Domain Structure for InterPro Entry Q9TNN7
    Graphical View of Domain Structure for InterPro Entry Q29963
    Graphical View of Domain Structure for InterPro Entry P10321
    Graphical View of Domain Structure for InterPro Entry P30505
    Graphical View of Domain Structure for InterPro Entry P30508
    Graphical View of Domain Structure for InterPro Entry P30510
    Graphical View of Domain Structure for InterPro Entry Q07000
    Graphical View of Domain Structure for InterPro Entry Q29960
    Graphical View of Domain Structure for InterPro Entry Q95604
    Graphical View of Domain Structure for InterPro Entry Q29865

    ProtoNet protein and cluster: P30499

    3 Blocks protein families:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1C01_HUMAN, P30499
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C02_HUMAN, P30501
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C03_HUMAN, P04222
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C04_HUMAN, P30504
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C05_HUMAN, Q9TNN7
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C06_HUMAN, Q29963
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C07_HUMAN, P10321
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C08_HUMAN, P30505
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C12_HUMAN, P30508
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C14_HUMAN, P30510
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C15_HUMAN, Q07000
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C16_HUMAN, Q29960
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C17_HUMAN, Q95604
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C18_HUMAN, Q29865
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for HLA-C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
    UniProtKB/ace: 1C01_HUMAN, P30499 (see all)
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-C:
    HLA-C,alpha chain,44kDa,class Ia (see MHC1)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HLA-C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-C
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-C
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-C 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-C
    OriGene shRNA RFP: HLA-C
    OriGene siRNA: HLA-C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-C

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HLA-C

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-C
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-C (see all 3)
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    GenScript: all cDNA clones in your preferred vector: HLA-C (NM_002117)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-C 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HLA-C
    Search LifeMap BioReagents cell lines for HLA-C

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-C

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032393MHC class I receptor activity NAS1384166


    HLA-C for ontologies           About GeneDecksing



    Pathways & Interactions
    for HLA-C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of peptide bound MHC class I complex to cell surface
    		Translocation of peptide bound MHC class I complex to cell surface1.00
    		Endosomal/Vacuolar pathway0.78
    		Journey of cargo through Golgi complex1.00
    		Peptide loading on MHC class I in phagosome0.70
    		Expression of peptide bound class I MHC on cell surface1.00
    		Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.28
    		Export of peptide loaded MHC class I complex to PM1.00
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    3Ubiquitinated Orc1 is degraded by the proteasome
    		ER-Phagosome pathway0.74
    		Proteasome Degradation0.56
    		Antigen processing-Cross presentation0.60
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    5Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HLA-C
        Immune response Antigen presentation by MHC class I
    Immune response Role of DAP12 receptors in NK cells

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-C
        CDC42 Pathway
    CTL Mediated Apoptosis

    2 GeneGo (Thomson Reuters) Pathways for HLA-C
        Immune response Antigen presentation by MHC class I
    Immune response Role of DAP12 receptors in NK cells

    1 BioSystems Pathway for HLA-C 
        Proteasome Degradation

    5/21        Reactome Pathways for HLA-C (see all 21)
        Endosomal/Vacuolar pathway
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Interferon alpha/beta signaling
    Expression of IFN-induced genes
    ER-Phagosome pathway


    5/10         Kegg Pathways  (Kegg details for HLA-C) (see all 10):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    HLA-C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/72 Interacting proteins for HLA-C (Q070002, 3 ENSP000003654024 P305042, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617692, ENSP000003408584MINT-24804 STRING: ENSP00000340858
    KIR2DL1ENSP000003367694STRING: ENSP00000336769
    KIR2DL3ENSP000003422154STRING: ENSP00000342215
    CD8AENSP000002836354STRING: ENSP00000283635
    KIR2DL2ENSP000003836454STRING: ENSP00000383645
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0006955immune response NAS1384166
    GO:0019048virus-host interaction IEA--


    HLA-C for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLA-C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-C
    1 PharmGKB related drug/compound annotation for HLA-C gene
    Drug/compound PharmGKB Annotation
    nevirapineCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about HLA-C / 1C18 

    Transcripts
    for HLA-C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLA-C gene (2 alternative transcripts): 
    NM_001243042.1  NM_002117.5  

    Unigene Clusters for HLA-C:

    Major histocompatibility complex, class I, C
    Hs.656020  [show with all ESTs], Hs.743218  [show with all ESTs]
    Unigene Representative Sequences: NR_027822, BM455140
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466892 ENST00000470363 ENST00000487245(uc011dnj.2) ENST00000376228
    ENST00000383329(uc021yuk.1) ENST00000396254 ENST00000376237(uc003nsy.3 uc011dnl.2)
    ENST00000458701 ENST00000415537 ENST00000495835 ENST00000484378 ENST00000539307


    miRNA
    Products:             		 OriGene 3'-UTR Clone: HLA-C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-C
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-C
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-C 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-C
    OriGene shRNA RFP: HLA-C
    OriGene siRNA: HLA-C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-C
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-C
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-C (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HLA-C (NM_002117)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-C 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-C
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HLA-C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-C

    Additional cDNA sequence: 

    AF168611.1 AF196489.1 AF405691.1 AJ005199.1 AJ010748.1 AJ010749.1 AJ440716.2 AJ537578.1 
    AK024836.1 AK130592.1 AK301283.1 AK304527.1 AM237285.2 AY732487.1 BC002463.1 BC004489.2 
    BC007814.2 BC008457.1 BC010542.1 BC033293.1 BC041078.1 D12471.1 D31817.1 D38526.1 
    D49552.1 D49819.1 D49820.1 D50852.1 D50853.1 D50854.1 D64145.1 D64146.1 
    D64147.1 D64148.1 D64149.1 D64150.1 D64151.1 D64152.1 D83029.1 D83030.1 
    D83031.1 D83741.1 FN662479.1 JN887337.1 L20091.1 L38251.1 M11886.1 M12679.1 
    M21963.1 M24031.1 M24096.1 M24097.1 M26429.1 M26430.1 M26431.1 M26712.1 
    M28160.1 M28206.1 M28207.1 M84171.1 M84172.1 M84173.1 M84174.1 M84386.1 
    M99388.1 M99389.1 M99390.1 U06487.1 U06695.1 U06696.1 U06835.1 U07230.1 
    U09853.1 U41386.1 U41420.1 U57028.1 U62824.1 X58536.1 X67818.1 X70856.1 
    X70857.1 X73518.1 X76189.1 X78343.1 X82122.1 X83394.1 X87841.1 X96582.1 
    X97321.1 X98742.1 X99704.1 Y09156.1 Y10520.1 Y11843.1 Z15144.1 Z33459.1 
    Z46809.1 Z46810.1 Z47377.1 Z83247.1 Z83803.1 

    24/156 DOTS entries (see all 156):

    DT.95331860  DT.95331815  DT.91783964  DT.97870100  DT.100869596  DT.87018278  DT.121310580  DT.100039972 
    DT.100802354  DT.91877609  DT.85100906  DT.100860136  DT.100046108  DT.91783937  DT.95331704  DT.87013257 
    DT.121310323  DT.100857890  DT.87011008  DT.85100728  DT.100866176  DT.100870293  DT.100046124  DT.121310455 

    24/251 AceView cDNA sequences (see all 251):

    BX459241 BM917107 BI906452 BQ892338 AL553833 CN480960 BQ719235 AW401719 
    BX378406 AW402264 CD620604 BM148269 BM561565 AW239462 BQ716678 AL537877 
    BQ720232 BI912419 BG744129 BM918142 BU788986 F00565 BG327758 BG898693 

    GeneLoc Exon Structure


    Expression
    for HLA-C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCAGTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HLA-C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-C

    SOURCE GeneReport for Unigene clusters: Hs.656020 Hs.743218
        SABiosciences Custom PCR Arrays for HLA-C
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-C
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HLA-C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-C
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-C

    Orthologs
    for HLA-C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-C gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NM79_CHICK6
    --
    (see all 15)    		 --
    		 44(a)
    41(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 16(40458-41204)
    16(204323-205564)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 25)    		 --
    		 47(a)
    46(a)
    (see all 25)    		 many ↔ many
    many ↔ many
    (see all 25)    		 AAWZ02039289(783-2823)
    AAWZ02040156(3915-5955)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01089980.16
    si:ch211-287j19.66
    (see all 7)    		 si:ch211-287j19.6
    (see all 7)    		 25(a)
    25(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 3(502131-512626)
    1(47613228-47619236)


    ENSEMBL Gene Tree for HLA-C (if available)
    TreeFam Gene Tree for HLA-C (if available) 

    Paralogs
    for HLA-C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-C gene
    HLA-F2  MR12  HFE2  HLA-B2  FCGRT2  HLA-E2  HLA-A2  HLA-G2  
    18/140 SIMAP similar genes for HLA-C using alignment to 3826 protein entries:     1C01_HUMAN (see all proteins) (see all similar genes):
    MHC class I    Cw*08    HLA-Cw3    HLA-A*0201V3    HLA-Cw*15P    Cw
    HLA-Cw*02023    HLAC    HLA-Cw*0707    HLA-Cw*07    MHC    HLA-Cw*
    HLA-Cw*03MAC    HLA-Cw    HLA-Cw2    HLC-C    HLA-Cw*03    HLA-CW

    HLA-C for paralogs           About GeneDecksing



    Genomic Variants
    for HLA-C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: 1C18_HUMAN, Q29865
    Polymorphism: The following alleles of Cw-1 are known: Cw*01:01 (Cw1.1), Cw*01:02 (Cw1.2), Cw*01:03 and Cw*01:04. The
    sequence shown is that of Cw*01:01
    Polymorphism: The following alleles of Cw-2 are known: Cw*02:01 (Cw2.1) and Cw*02:02 (Cw2.2). The sequence shown is
    that of Cw*02:01
    Polymorphism: The following alleles of Cw-3 are known: Cw*03:02 (Cw3.2), Cw*03:03, Cw*03:04 (Cw3.1), Cw*03:05,
    Cw*03:06, Cw*03:07, Cw*03:08, Cw*03:09 and Cw*03:13. The sequence shown is that of Cw*03:04
    Polymorphism: The following alleles of Cw-4 are known: Cw*04:01 Cw*04:03, Cw*04:04, Cw*04:05 and Cw*04:06. The sequence
    shown is that of Cw*04:01
    Polymorphism: The following alleles of Cw-5 are known: Cw*05:01 Cw*0502, Cw*05:03 and Cw*05:04. The sequence shown is
    that of Cw*05:01
    Polymorphism: The following alleles of Cw-6 are known: Cw*06:02 Cw*06:03 and Cw*06:04. Allele Cw*062 is a risk factor
    that confers susceptibility to psoriasis. The sequence shown is that of Cw*06:02
    Polymorphism: The following alleles of Cw-7 are known: Cw*07:01, Cw*07:02, Cw*07:03, Cw*07:04, Cw*07:06, Cw*07:09 and
    Cw*07:11. The sequence shown is that of Cw*07:02
    Polymorphism: The following alleles of Cw-8 are known: Cw*08:01 (Cw8.1), Cw*08:02 (Cw8.2) and Cw*08:03. The sequence
    shown is that of Cw*08:01
    Polymorphism: The following alleles of Cw-12 are known: Cw*12:02, Cw*12:03, Cw*12:04, Cw*12:05, Cw*12:06, Cw*12:07,
    Cw*12:08 and Cw*12:09. The sequence shown is that of Cw*12:02
    Polymorphism: The following alleles of Cw-14 are known: Cw*14:02 (CB-1), Cw*14:03 (CX44) and Cw*14:04. The sequence
    shown is that of Cw*14:02
    Polymorphism: The following alleles of Cw-15 are known: Cw*15:02, Cw*15:03, Cw*15:04, Cw*15:05, Cw*15:10 and Cw*15:11.
    The sequence shown is that of Cw*15:02
    Polymorphism: The following alleles of Cw-16 are known: Cw*16:01, Cw*16:02 (CW*CL10V) and Cw*16:04. The sequence shown
    is that of Cw*16:01
    Polymorphism: The following alleles of Cw-17 are known: Cw*17:01, Cw*17:02 and Cw*17:03. The sequence shown is that of
    Cw*17:01
    Polymorphism: The following alleles of Cw-18 are known: Cw*18:01 (Cw*04GB) and Cw*18:02 (Cw*18GB). The sequence shown
    is that of Cw*18:01


    10/924 NCBI SNPs in HLA-C are shown (see all 924)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1162291441,2
    		C,F,histocompatibility31236800(+) GGGTGG/AGCTGT 2 -- ut312Minor allele frequency- A:0.04WA EU 705
    rs10496501,2
    		C,F,histocompatibility31236808(-) GTGGAG/CAGACA 2 -- ut317Minor allele frequency- C:0.07MN NA CSA WA EA EU 1138
    rs10496631,2
    		C,F,histocompatibility31236813(-) AGGAGG/TTGGAG 2 -- ut313Minor allele frequency- T:0.03WA EU 713
    rs10496681,2
    		C,F,histocompatibility31236821(-) ATAATG/ATGAGG 2 -- ut313Minor allele frequency- A:0.03WA EU 713
    rs412890691,2
    		C,Fhistocompatibility31236836(+) ACAGGA/GACGCA 2 -- ut312Minor allele frequency- G:0.03CSA EU 409
    rs31760071,2
    		C,F,histocompatibility31236845(-) GAATGT/CGTCTG 2 -- ut31 ese34Minor allele frequency- C:0.05MN WA NA EU 1015
    rs10497241,2
    		C,F,histocompatibility31236862(-) TTTCTG/ACAAAG 2 -- ut313Minor allele frequency- A:0.05WA CSA EU 597
    rs10498531,2
    		C,F,H,histocompatibility31236900(-) CACCTC/TTCCTT 2 -- ut31 ese3 trp328Minor allele frequency- T:0.11NS EA NA MN WA EU 4579
    rs178854361,2
    		C,F,histocompatibility31237002(-) AGTGTC/GATCGC 2 -- int14Minor allele frequency- G:0.11NA EA EU 1565
    rs39983811,2
    		C,histocompatibility31237014(+) TGAACA/GGCCCA 2 -- int12Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for HLA-C (31236526 - 31239907 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for HLA-C
         10 CNVs: 7561 3601 99487 31272 69375 32779 5387 69376 31273 8508
    Human Gene Mutation Database (HGMD): HLA-C

    Locus Specific Mutation Databases (LSDB): HLA-C

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-C
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-C

    Disorders / Diseases
    for HLA-C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLA-C for disorders           About GeneDecksing

    OMIM gene information: 142840   
    OMIM disorders: 177900  609423  
    UniProtKB/Swiss-Prot: 1C18_HUMAN, Q29865
  • Genetic variations in HLA-C are a cause of susceptibility to psoriasis type 1 (PSORS1) [MIM:177900]. Psoriasis
    • is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly
    plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation
    and infiltration of inflammatory cells into the dermis and epidermis

    20/157 diseases for HLA-C (see all 157):    About MalaCards
    vogt-koyanagi-harada disease    hiv-1 viremia    htlv-1 associated myelopathy    relapsing-remitting multiple sclerosis
    paroxysmal nocturnal hemoglobinuria    toxic epidermal necrolysis    stevens-johnson syndrome    birdshot chorioretinopathy
    hypersensitivity reaction type ii disease    sympathetic ophthalmia    tropical spastic paraparesis    pityriasis rosea
    age related macular degeneration    human immunodeficiency virus infectious disease    hemolytic-uremic syndrome    neuromyelitis optica
    graft versus host disease    sclerosing cholangitis    spastic paraparesis    lichen planus

    20/25 diseases from the University of Copenhagen DISEASES database for HLA-C (see all 25):
    Hypersensitivity reaction type II disease     Leukemia     Psoriasis     Diabetes mellitus
    Ankylosing spondylitis     Arthritis     Multiple sclerosis     Liver disease
    Melanoma     Uveitis     Hyperthyroidism     Lung disease
    Bone marrow disease     Stevens-Johnson syndrome     Anemia     Vascular disease
    Psoriatic arthritis     Hepatitis B     Lymphoma     Connective tissue disease

    10/11 Novoseek disease relationships for HLA-C gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 65.8 24 10773694 (3), 10545595 (3), 17666781 (2), 10888604 (2) (see all 12)
    behcet disease 43.7 9 8872174 (3), 8896070 (1)
    skin diseases 43.3 1 10888604 (1)
    arthritis psoriatic 38.5 6 15539411 (2), 16313304 (2), 20476959 (1)
    miscarriage 29.4 1 1471708 (1)
    cholangitis primary sclerosing 26.4 2 9731555 (2)
    hepatitis c 7.61 2 16571411 (1), 20456039 (1)
    leukemia 0 2 10366797 (1), 10715516 (1)
    aids 0 2 19115949 (1)
    tumors 0 3 9788622 (1), 12714638 (1), 17023986 (1)

    Genetic Association Database (GAD): HLA-C
    Human Genome Epidemiology (HuGE) Navigator: HLA-C (2858 documents)

    Export disorders for HLA-C gene to outside databases

    Publications
    for HLA-C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-C gene, integrated from 9 sources (see all 826):
    (articles sorted by number of sources associating them with HLA-C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort. (PubMed id 15539411)1, 4, 9 Lascorz J....Reis A. (2005)
    2. The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene. (PubMed id 11348465)1, 4, 9 O'Brien K.P.... Staahle-Baeckdahl M. (2001)
    3. Association of HLA class I alleles with aloplecia areata in Chinese Hans. (PubMed id 16185849)1, 4 Xiao F.L....Zhang X.J. (2006)
    4. HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis. (PubMed id 16365741)1, 4 Campillo J.A....Alvarez-Lopez M.R. (2006)
    5. Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population. (PubMed id 15853898)1, 4 Lee K.W....Yang S.Y. (2005)
    6. The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis. (PubMed id 15654960)1, 4 Allen M.H....Barker J.N. (2005)
    7. Analysis of HLA class I and class II gene polymorphisms in Japanese patients with human T-cell lymphotropic virus type 1-associated uveitis. (PubMed id 16019679)1, 4 Kaminagayoshi T....Sakamoto T. (2005)
    8. HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3. (PubMed id 15848982)1, 4 Holm S.J....O'Brien K.P. (2005)
    9. MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies. (PubMed id 16029431)1, 4 Malkki M....Petersdorf E. (2005)
    10. The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population. (PubMed id 16297191)1, 4 Martinez-Borra J....Lopez-Larrea C. (2005)

    External Searches for HLA-C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HLA-C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3107 HGNC: 4933 AceView: HLA-C.1 Ensembl:ENSG00000204525 euGenes: HUgn3107
    ECgene: HLA-C Kegg: 3107 H-InvDB: HLA-C

    Other Databases showing HLA-C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLA-C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HLA-C Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HLA-C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-C gene:
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     Browse Kits and Assays available from EMD Millipore
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     Regulatory tfbs in HLA-C promoter
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     HLA-C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HLA-C
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     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-C
     SwitchGear 3'UTR luciferase reporter plasmids for HLA-C
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-C
           
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