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Aliases for HLA-B Gene

Aliases for HLA-B Gene

  • Major Histocompatibility Complex, Class I, B 2 3 5
  • HLAB 3 4
  • HLA Class I Histocompatibility Antigen, B-12 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-21 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-5 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B Alpha Chain 3
  • MHC Class I Antigen HLA-B Alpha Chain 3
  • MHC Class I Antigen HLA-B Heavy Chain 3
  • MHC HLA-B Transmembrane Glycoprotein 3
  • MHC HLA-B Cell Surface Glycoprotein 3
  • Leukocyte Antigen Class I-B 3
  • HLA Class I Antigen HLA-B 3
  • MHC Class I Antigen SHCHA 3
  • MHC Class I Antigen B*13 4
  • MHC Class I Antigen B*14 4
  • MHC Class I Antigen B*15 4
  • MHC Class I Antigen B*18 4
  • MHC Class I Antigen B*27 4
  • MHC Class I Antigen B*35 4
  • MHC Class I Antigen B*37 4
  • MHC Class I Antigen B*38 4
  • MHC Class I Antigen B*39 4
  • MHC Class I Antigen B*40 4
  • MHC Class I Antigen B*41 4
  • MHC Class I Antigen B*42 4
  • MHC Class I Antigen B*44 4
  • MHC Class I Antigen B*45 4
  • MHC Class I Antigen B*46 4
  • MHC Class I Antigen B*47 4
  • MHC Class I Antigen B*48 4
  • MHC Class I Antigen B*49 4
  • MHC Class I Antigen B*50 4
  • MHC Class I Antigen B*51 4
  • MHC Class I Antigen B*52 4
  • MHC Class I Antigen B*53 4
  • MHC Class I Antigen B*54 4
  • MHC Class I Antigen B*55 4
  • MHC Class I Antigen B*56 4
  • MHC Class I Antigen B*57 4
  • MHC Class I Antigen B*58 4
  • MHC Class I Antigen B*59 4
  • MHC Class I Antigen B*67 4
  • MHC Class I Antigen B*73 4
  • MHC Class I Antigen B*78 4
  • MHC Class I Antigen B*81 4
  • MHC Class I Antigen B*82 4
  • MHC Class I Antigen B*7 4
  • MHC Class I Antigen B*8 4
  • Ankylosing Spondylitis 2
  • MHC Class I Molecule 3
  • MHC Class 1 Antigen 3
  • B-4901 3
  • Bw-22 4
  • Bw-41 4
  • Bw-44 4
  • Bw-45 4
  • Bw-46 4
  • Bw-47 4
  • Bw-48 4
  • Bw-50 4
  • Bw-52 4
  • Bw-53 4
  • Bw-54 4
  • Bw-55 4
  • Bw-56 4
  • Bw-57 4
  • Bw-58 4
  • Bw-60 4
  • Bw-4 4
  • BDT 4
  • AS 3

External Ids for HLA-B Gene

Previous HGNC Symbols for HLA-B Gene

  • AS

Previous GeneCards Identifiers for HLA-B Gene

  • GC06M031376
  • GC06M031426
  • GC06M031342
  • GC06M031429
  • GC06M031345
  • GC06M031321
  • GC06M031112
  • GC06M031354

Summaries for HLA-B Gene

Entrez Gene Summary for HLA-B Gene

  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-B Gene

HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include Hypersensitivity Syndrome, Carbamazepine-Induced and Spondyloarthropathy 1. Among its related pathways are Allograft rejection and Type II interferon signaling (IFNG). GO annotations related to this gene include receptor binding and peptide antigen binding. An important paralog of this gene is HLA-C.

Gene Wiki entry for HLA-B Gene

PharmGKB "VIP" Summary for HLA-B Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-B Gene

Genomics for HLA-B Gene

Regulatory Elements for HLA-B Gene

Enhancers for HLA-B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H031353 1.7 FANTOM5 Ensembl ENCODE dbSUPER 27 +1.0 1021 7 HDGF PKNOX1 ATF1 NSD2 ZNF2 GLIS2 ZNF143 ZNF207 FOS RUNX3 HLA-C HLA-B DDX39B ENSG00000271581 MICA LY6G5B ATF6B RPL7P4 MICA-AS1 SKIV2L
GH06H031733 1.9 FANTOM5 ENCODE dbSUPER 11.6 -380.2 -380243 8.5 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC ZC3H11A LY6G5B ATF6B DDX39B LSM2 CSNK2B GPANK1 VARS NFKBIL1 SKIV2L MSH5
GH06H031269 1.6 FANTOM5 ENCODE dbSUPER 13.2 +85.8 85751 4.4 HDGF PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF2 YY1 ZNF121 GLIS2 HLA-C PSORS1C3 PPT2 TNXB LSM2 PSORS1C2 HCG18 HCG27 ENSG00000229836 TCF19
GH06H031619 1.4 ENCODE dbSUPER 9.8 -264.0 -264016 4 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 LSM2 ATF6B GTF2H4 LY6G5B MDC1 PPT2 DDX39B EGFL8 NFKBIL1 DXO
GH06H032175 1.4 ENCODE dbSUPER 9.7 -820.5 -820548 5.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B BRD2 LSM2 LY6G5B DDX39B ATF6B GPANK1 VARS TNXB MSH5 BAG6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HLA-B on UCSC Golden Path with GeneCards custom track

Promoters for HLA-B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195527 412 2001 HDGF ATF1 INSM2 KLF17 ZNF2 RFX5 GLIS2 ZNF143 FOS ZNF391

Genomic Locations for HLA-B Gene

Genomic Locations for HLA-B Gene
chr6:31,269,491-31,357,212
(GRCh38/hg38)
Size:
87,722 bases
Orientation:
Minus strand
chr6:31,321,649-31,324,989
(GRCh37/hg19)

Genomic View for HLA-B Gene

Genes around HLA-B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-B Gene

  • Protein details for HLA-B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01889-1B07_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, B-7 alpha chain
    Protein Accession:
    P01889
    Secondary Accessions:
    • Q29638
    • Q29681
    • Q29854
    • Q29861
    • Q31613
    • Q5SRJ2
    • Q9GIX1
    • Q9TP95

    Protein attributes for HLA-B Gene

    Size:
    362 amino acids
    Molecular mass:
    40460 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I.

    Three dimensional structures from OCA and Proteopedia for HLA-B Gene

neXtProt entry for HLA-B Gene

Other Protein References for HLA-B Gene

No data available for DME Specific Peptides for HLA-B Gene

Domains & Families for HLA-B Gene

Gene Families for HLA-B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P01889

UniProtKB/Swiss-Prot:

1B38_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-B: view

Function for HLA-B Gene

Phenotypes From GWAS Catalog for HLA-B Gene

Gene Ontology (GO) - Molecular Function for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 18322206
GO:0042605 peptide antigen binding ISS,IBA --
genes like me logo Genes that share ontologies with HLA-B: view
genes like me logo Genes that share phenotypes with HLA-B: view

Human Phenotype Ontology for HLA-B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-B Gene

Localization for HLA-B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-B gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 4
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane TAS,IBA --
GO:0005887 integral component of plasma membrane NAS --
genes like me logo Genes that share ontologies with HLA-B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-B Gene

Pathways & Interactions for HLA-B Gene

genes like me logo Genes that share pathways with HLA-B: view