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Aliases for HLA-B Gene

Aliases for HLA-B Gene

  • Major Histocompatibility Complex, Class I, B 2 3 5
  • HLAB 3 4
  • HLA Class I Histocompatibility Antigen, B-12 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-21 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-5 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B Alpha Chain 3
  • MHC Class I Antigen HLA-B Alpha Chain 3
  • MHC Class I Antigen HLA-B Heavy Chain 3
  • MHC HLA-B Transmembrane Glycoprotein 3
  • MHC HLA-B Cell Surface Glycoprotein 3
  • Leukocyte Antigen Class I-B 3
  • HLA Class I Antigen HLA-B 3
  • MHC Class I Antigen SHCHA 3
  • MHC Class I Antigen B*13 4
  • MHC Class I Antigen B*14 4
  • MHC Class I Antigen B*15 4
  • MHC Class I Antigen B*18 4
  • MHC Class I Antigen B*27 4
  • MHC Class I Antigen B*35 4
  • MHC Class I Antigen B*37 4
  • MHC Class I Antigen B*38 4
  • MHC Class I Antigen B*39 4
  • MHC Class I Antigen B*40 4
  • MHC Class I Antigen B*41 4
  • MHC Class I Antigen B*42 4
  • MHC Class I Antigen B*44 4
  • MHC Class I Antigen B*45 4
  • MHC Class I Antigen B*46 4
  • MHC Class I Antigen B*47 4
  • MHC Class I Antigen B*48 4
  • MHC Class I Antigen B*49 4
  • MHC Class I Antigen B*50 4
  • MHC Class I Antigen B*51 4
  • MHC Class I Antigen B*52 4
  • MHC Class I Antigen B*53 4
  • MHC Class I Antigen B*54 4
  • MHC Class I Antigen B*55 4
  • MHC Class I Antigen B*56 4
  • MHC Class I Antigen B*57 4
  • MHC Class I Antigen B*58 4
  • MHC Class I Antigen B*59 4
  • MHC Class I Antigen B*67 4
  • MHC Class I Antigen B*73 4
  • MHC Class I Antigen B*78 4
  • MHC Class I Antigen B*81 4
  • MHC Class I Antigen B*82 4
  • MHC Class I Antigen B*7 4
  • MHC Class I Antigen B*8 4
  • Ankylosing Spondylitis 2
  • MHC Class I Molecule 3
  • MHC Class 1 Antigen 3
  • B-4901 3
  • Bw-22 4
  • Bw-41 4
  • Bw-44 4
  • Bw-45 4
  • Bw-46 4
  • Bw-47 4
  • Bw-48 4
  • Bw-50 4
  • Bw-52 4
  • Bw-53 4
  • Bw-54 4
  • Bw-55 4
  • Bw-56 4
  • Bw-57 4
  • Bw-58 4
  • Bw-60 4
  • Bw-4 4
  • BDT 4
  • AS 3

External Ids for HLA-B Gene

Previous HGNC Symbols for HLA-B Gene

  • AS

Previous GeneCards Identifiers for HLA-B Gene

  • GC06M031376
  • GC06M031426
  • GC06M031342
  • GC06M031429
  • GC06M031345
  • GC06M031321
  • GC06M031112

Summaries for HLA-B Gene

Entrez Gene Summary for HLA-B Gene

  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-B Gene

HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include Spondyloarthropathy 1 and Hypersensitivity Syndrome, Carbamazepine-Induced. Among its related pathways are Interferon gamma signaling and HTLV-I infection. GO annotations related to this gene include receptor binding and peptide antigen binding. An important paralog of this gene is HLA-C.

Gene Wiki entry for HLA-B Gene

PharmGKB "VIP" Summary for HLA-B Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-B Gene

Genomics for HLA-B Gene

Regulatory Elements for HLA-B Gene

Enhancers for HLA-B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F031352 0.8 FANTOM5 ENCODE 27 +1.0 1021 7.0 HDGF PKNOX1 ATF1 ZNF493 WRNIP1 ZFP64 SIN3A NSD2 ZNF2 GLIS2 LY6G5B DDX39B ATF6B NFKBIL1 LSM2 PPP1R10 DHX16 HLA-C PPT2 GTF2H4
GH06F031269 0.8 FANTOM5 ENCODE 13.2 +85.8 85751 4.4 HDGF PKNOX1 ATF1 WRNIP1 ARID4B GLI4 ZNF2 ZNF121 GLIS2 ZNF416 HLA-C PSORS1C3 PPT2 DDX39B LY6G5B TCF19 LSM2 PSORS1C2 ATF6B MICA
GH06F031351 0.2 ENCODE 11.7 +5.3 5255 0.4 POLR2A CBFB HLA-C PSORS1C2 PSORS1C1 PSORS1C3 HCG27 HLA-B MICA CCHCR1 POU5F1 PIR46739
GH06F031733 0.9 FANTOM5 ENCODE 11.5 -380.2 -380243 8.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF263 SP3 LY6G5C MICA LSM2 EHMT2 LY6G5B DXO GTF2H4 VARS ABHD16A ATF6B
GH06F031461 0.2 ENCODE 8.5 -106.0 -106029 2.7 TBP CBX3 ATF1 WRNIP1 ZNF76 SIN3A ARID4B ZNF48 BRCA1 RFX5 HLA-C MICB GNL1 EHMT2 PSORS1C2 MICA HLA-B SKIV2L LOC101929072 ENSG00000272501
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HLA-B on UCSC Golden Path with GeneCards custom track

Promoters for HLA-B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000487828 412 2401 HDGF TBP PKNOX1 ATF1 TBL1XR1 WRNIP1 INSM2 SIN3A KLF17 ZNF2

Genomic Location for HLA-B Gene

Chromosome:
6
Start:
31,353,868 bp from pter
End:
31,357,212 bp from pter
Size:
3,345 bases
Orientation:
Minus strand

Genomic View for HLA-B Gene

Genes around HLA-B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-B Gene

  • Protein details for HLA-B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01889-1B07_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, B-7 alpha chain
    Protein Accession:
    P01889
    Secondary Accessions:
    • Q29638
    • Q29681
    • Q29854
    • Q29861
    • Q31613
    • Q5SRJ2
    • Q9GIX1
    • Q9TP95

    Protein attributes for HLA-B Gene

    Size:
    362 amino acids
    Molecular mass:
    40460 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I.

    Three dimensional structures from OCA and Proteopedia for HLA-B Gene

neXtProt entry for HLA-B Gene

Other Protein References for HLA-B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HLA-B Gene

Domains & Families for HLA-B Gene

Graphical View of Domain Structure for InterPro Entry

P01889

UniProtKB/Swiss-Prot:

1B38_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-B: view

Function for HLA-B Gene

Gene Ontology (GO) - Molecular Function for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0005102 receptor binding IPI --
GO:0042605 peptide antigen binding ISS --
genes like me logo Genes that share ontologies with HLA-B: view
genes like me logo Genes that share phenotypes with HLA-B: view

Human Phenotype Ontology for HLA-B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for HLA-B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-B Gene

Localization for HLA-B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-B Gene COMPARTMENTS Subcellular localization image for HLA-B gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
plasma membrane 5
endosome 4
cytoskeleton 2
cytosol 2
lysosome 2
nucleus 2
vacuole 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane IBA,TAS --
GO:0005887 integral component of plasma membrane NAS --
genes like me logo Genes that share ontologies with HLA-B: view

Pathways & Interactions for HLA-B Gene

genes like me logo Genes that share pathways with HLA-B: view