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Aliases &
Descriptions
for HLA-B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| AS 2 | | B'DT 3 | | B-12 3 | | B-21 3 | | B-5 3 | | Bw-22 3 | | Bw-4 3 | | Bw-41 3 | | Bw-44 3 | | Bw-45 3 | | Bw-46 3 | | Bw-47 3 | | Bw-48 3 | | Bw-50 3 | | Bw-52 3 | | Bw-53 3 | | Bw-54 3 | | Bw-55 3 | | Bw-56 3 | | Bw-57 3 | | Bw-58 3 | | Bw-60 3 | | HLA-B-7301 2 | | HLA-B73 2 | | HLAB 2, 3 | | HLAC 2 | | MGC111087 2 | | OTTHUMP00000029212 2 | | OTTHUMP00000034826 2 | | SPDA1 2, 5 |
| | | Descriptions |
|---|
| HLA class I histocompatibility antigen, B alpha chain 2 | | HLA class I histocompatibility antigen, B-7 alpha chain 2 | | HLA class I histocompatibility antigen, Cw-5 alpha chain 2 | | HLA-B alpha chain (HLA-B*7301) 2 | | MHC Class I HLA heavy chain 2 | | MHC HLA-B cell surface glycoprotein 2 | | MHC class I antigen B*13 3 | | MHC class I antigen B*14 3 | | MHC class I antigen B*15 3 | | MHC class I antigen B*18 3 | | MHC class I antigen B*27 3 | | MHC class I antigen B*35 3 | | MHC class I antigen B*37 3 | | MHC class I antigen B*38 3 | | MHC class I antigen B*39 3 | | MHC class I antigen B*40 3 | | MHC class I antigen B*41 3 | | MHC class I antigen B*42 3 | | MHC class I antigen B*44 3 | | MHC class I antigen B*45 3 | | MHC class I antigen B*46 3 | | MHC class I antigen B*47 3 | | MHC class I antigen B*48 3 | | MHC class I antigen B*49 3 | | MHC class I antigen B*50 3 | | MHC class I antigen B*51 3 | | MHC class I antigen B*52 3 | | MHC class I antigen B*53 3 | | MHC class I antigen B*54 3 | | MHC class I antigen B*55 3 | | MHC class I antigen B*56 3 | | MHC class I antigen B*57 3 | | MHC class I antigen B*58 3 | | MHC class I antigen B*59 3 | | MHC class I antigen B*67 3 | | MHC class I antigen B*7 3 | | MHC class I antigen B*73 3 | | MHC class I antigen B*78 3 | | MHC class I antigen B*8 3 | | MHC class I antigen B*81 3 | | MHC class I antigen B*82 3 | | MHC class I antigen GN00104 2 | | MHC class I antigen HLA-B heavy chain 2 | | MHC class I antigen SHCHA 2 | | ankylosing spondylitis 1 | | leukocyte antigen class I-B 2 | | lymphocyte antigen 2 | | major histocompatibility complex, class I, B 2 |
|
| |
Search outside databases for aliases for HLA-B genePrevious GC identifers: GC06M031376 GC06M031426 GC06M031342 GC06M031345 |
Summaries
for HLA-B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HLA-B:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer
consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored
in the membrane. Class I molecules play a central role in the immune system by presenting peptides
derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy
chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide,
exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the
alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic
tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity
of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and
kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq]
UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718Function: Involved in the presentation of foreign antigens to the immune systemGene Wiki entry for HLA-B |
Genomic Location
for HLA-B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the HLA-B gene 
Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3HLA-B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031429:
(about GC identifiers)
Start:
|
31,429,628 bp from pter |
End:
|
31,432,914 bp from pter |
Size:
|
3,287 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113893.1
| Proteins
for HLA-B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-7 alpha chain precursor Size: 362 amino acids; 40460 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29638 Q29681 Q29854 Q29861 Q31613 Q9GIX1 Q9TP95UniProtKB/Swiss-Prot: 1B08_HUMAN, P30460 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-8 alpha chain precursor Size: 362 amino acids; 40331 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from  and Proteopedia  :1AGB (3D)
1AGC (3D)
1AGD (3D)
1AGE (3D)
1AGF (3D)
1M05 (3D)
1MI5 (3D)
3FFC (3D)
Secondary accessions: O62901 O95730 O98140 P79542 Q95369 Q95J00 Q9GJ20 Q9MY78 Q9MYF4 Q9TQH6 Q9TQM2
Q9UQT0UniProtKB/Swiss-Prot: 1B13_HUMAN, P30461 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-13 alpha chain precursor Size: 362 amino acids; 40474 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02956 O78180 Q29661 Q29933 Q9GIY5UniProtKB/Swiss-Prot: 1B14_HUMAN, P30462 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-14 alpha chain precursor Size: 362 amino acids; 40358 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02862 P30463UniProtKB/Swiss-Prot: 1B15_HUMAN, P30464 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-15 alpha chain precursor Size: 362 amino acids; 40388 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :1XR8 (3D)
1XR9 (3D)
3C9N (3D)
Secondary accessions: B0V0B8 P30465 P30513 Q29633 Q29636 Q29829 Q29953 Q29982 Q95343 Q95344 Q9BD06UniProtKB/Swiss-Prot: 1B18_HUMAN, P30466 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-18 alpha chain precursor Size: 362 amino acids; 40275 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O62897 Q29845 Q5JP37 Q9BCM6 Q9GJ23 Q9MY84 Q9MYC7 Q9TP37 Q9TQH7UniProtKB/Swiss-Prot: 1B27_HUMAN, P03989 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-27 alpha chain precursor Size: 362 amino acids; 40428 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :1HSA (3D)
1JGD (3D)
1JGE (3D)
1K5N (3D)
1OF2 (3D)
1OGT (3D)
1ROG (3D)
1ROH (3D)
1ROI (3D)
1ROJ (3D)
1ROK (3D)
1ROL (3D)
1UXS (3D)
1UXW (3D)
1W0V (3D)
1W0W (3D)
2A83 (3D)
2BSR (3D)
2BSS (3D)
2BST (3D)
3B3I (3D)
3B6S (3D)
3BP4 (3D)
3BP7 (3D)
3CZF (3D)
3D18 (3D)
3DTX (3D)
Secondary accessions: O19692 P10317 P10318 P19373 P30467 Q08136 Q29693 Q29846 Q29961UniProtKB/Swiss-Prot: 1B35_HUMAN, P30685 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-35 alpha chain precursor Size: 362 amino acids; 40455 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :1A1N (3D)
1A9B (3D)
1A9E (3D)
1CG9 (3D)
1XH3 (3D)
1ZHK (3D)
1ZHL (3D)
1ZSD (3D)
2AK4 (3D)
2AXF (3D)
2AXG (3D)
2CIK (3D)
2FYY (3D)
2FZ3 (3D)
2H6P (3D)
2NW3 (3D)
2NX5 (3D)
3BW9 (3D)
3BWA (3D)
Secondary accessions: O62919 P30468 P30469 P30470 P30471 P30472 P30473 P30474 Q9GJM7 Q9TPV2 Q9TQH3
Q9TQH9 Q9TQN4 Q9TQN6UniProtKB/Swiss-Prot: 1B37_HUMAN, P18463 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-37 alpha chain precursor Size: 362 amino acids; 40456 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19627 Q546L8 Q95HA3 Q95HA8 Q95HM9 Q9GJ31UniProtKB/Swiss-Prot: 1B38_HUMAN, Q95365 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-38 alpha chain precursor Size: 362 amino acids; 40416 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19779 O77959 O78160 Q29935 Q29936 Q95IB8 Q95IH5 Q9BCM8 Q9MY92 Q9MYG1 Q9TPT2UniProtKB/Swiss-Prot: 1B39_HUMAN, P30475 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-39 alpha chain precursor Size: 362 amino acids; 40328 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02960 O78217 P30476 P79504 Q29665 Q29697 Q29749 Q29847 Q29852 Q29858 Q8HWF0
Q9TPQ7UniProtKB/Swiss-Prot: 1B40_HUMAN, Q04826 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-40 alpha chain precursor Size: 362 amino acids; 40505 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19556 O19651 P01890 P30477 P30478 Q29762 Q29842 Q29855 Q30173 Q31603 Q9TPT6UniProtKB/Swiss-Prot: 1B41_HUMAN, P30479 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-41 alpha chain precursor Size: 362 amino acids; 40539 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19595 Q29848 Q5TK77 Q9MY79 Q9MY94UniProtKB/Swiss-Prot: 1B42_HUMAN, P30480 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-42 alpha chain precursor Size: 362 amino acids; 40333 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: P79555UniProtKB/Swiss-Prot: 1B44_HUMAN, P30481 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-44 alpha chain precursor Size: 362 amino acids; 40481 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :1M6O (3D)
1SYS (3D)
1SYV (3D)
3DX6 (3D)
3DX7 (3D)
3DX8 (3D)
3DXA (3D)
Secondary accessions: P10320 P30482 P79524 Q29850 Q5RIP1 Q860I4 Q861B5 Q9BCM7 Q9MYC3 Q9UQS8UniProtKB/Swiss-Prot: 1B45_HUMAN, P30483 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-45 alpha chain precursor Size: 362 amino acids; 40414 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9GIZ0 Q9MX21UniProtKB/Swiss-Prot: 1B46_HUMAN, P30484 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-46 alpha chain precursor Size: 362 amino acids; 40440 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9TPR2UniProtKB/Swiss-Prot: 1B47_HUMAN, P30485 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-47 alpha chain precursor Size: 362 amino acids; 40571 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19555 O77933 Q95392 Q9GIL3UniProtKB/Swiss-Prot: 1B48_HUMAN, P30486 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-48 alpha chain precursor Size: 362 amino acids; 40362 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29764UniProtKB/Swiss-Prot: 1B49_HUMAN, P30487 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-49 alpha chain precursor Size: 362 amino acids; 40581 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19625 Q9MY37 Q9MY93UniProtKB/Swiss-Prot: 1B50_HUMAN, P30488 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-50 alpha chain precursor Size: 362 amino acids; 40541 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19615 O19624 O19641 O19783 O46702 O78172 Q9TQG1UniProtKB/Swiss-Prot: 1B51_HUMAN, P18464 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-51 alpha chain precursor Size: 362 amino acids; 40566 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structure from and Proteopedia :1E27 (3D)
1E28 (3D)
Secondary accessions: O19675 O78173 P30489 Q29851 Q29857 Q96IT9 Q9MY43UniProtKB/Swiss-Prot: 1B52_HUMAN, P30490 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-52 alpha chain precursor Size: 362 amino acids; 40521 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9MY75 Q9TPT4UniProtKB/Swiss-Prot: 1B53_HUMAN, P30491 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-53 alpha chain precursor Size: 362 amino acids; 40495 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structure from and Proteopedia :1A1M (3D)
1A1O (3D)
Secondary accessions: O78053 O78138 Q30198 Q5TK76 Q9BD43 Q9GJF0 Q9MY42 Q9TP36 Q9TQH8UniProtKB/Swiss-Prot: 1B54_HUMAN, P30492 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-54 alpha chain precursor Size: 362 amino acids; 40380 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9TPQ9UniProtKB/Swiss-Prot: 1B55_HUMAN, P30493 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-55 alpha chain precursor Size: 362 amino acids; 40496 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O78163 P30494 P79489 P79523 Q8MGQ3 Q9GIZ9 Q9GJ00UniProtKB/Swiss-Prot: 1B56_HUMAN, P30495 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-56 alpha chain precursor Size: 362 amino acids; 40478 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19758 P30496 P79490 Q9GIM3 Q9GJ17 Q9TPR4UniProtKB/Swiss-Prot: 1B57_HUMAN, P18465 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-57 alpha chain precursor Size: 362 amino acids; 40224 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :2BVO (3D)
2BVP (3D)
2BVQ (3D)
2HJL (3D)
2RFX (3D)
Secondary accessions: O62917 P30497 P79496 Q29679 Q5QT24UniProtKB/Swiss-Prot: 1B58_HUMAN, P10319 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-58 alpha chain precursor Size: 362 amino acids; 40337 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29925 Q9TP35 Q9TPS6UniProtKB/Swiss-Prot: 1B59_HUMAN, Q29940 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-59 alpha chain precursor Size: 362 amino acids; 40584 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02957UniProtKB/Swiss-Prot: 1B67_HUMAN, Q29836 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-67 alpha chain precursor Size: 362 amino acids; 40342 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29678 Q8SNC5 Q95IA6 Q9BD38UniProtKB/Swiss-Prot: 1B73_HUMAN, Q31612 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-73 alpha chain precursor Size: 363 amino acids; 40435 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane proteinUniProtKB/Swiss-Prot: 1B78_HUMAN, P30498 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-78 alpha chain precursor Size: 362 amino acids; 40478 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O62915 Q29924 Q546M4UniProtKB/Swiss-Prot: 1B81_HUMAN, Q31610 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-81 alpha chain precursor Size: 362 amino acids; 40400 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane proteinUniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, B-82 alpha chain precursor Size: 362 amino acids; 40421 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29695 Q29742 Q8MHN4 Q9MY61 Q9MYB8Post-translational modifications:
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005505.2
Human Recombinant Proteins  | Browse
Drug Discovery Central at Invitrogen for human recombinant proteins |  | Browse Purified and Recombinant Proteins at Millipore |  | Browse Human Recombinant Proteins at Sigma-Aldrich |  |
Browse R&D Systems for human recombinant proteins |  | Browse recombinant and purified proteins available from Enzo Life Sciences |  | Recombinant Proteins from Abcam (HLA Class 1 A30 A31, HLA Class 1 B5, B49, B56, HLA Class I B8, HLA Class 1 B7, B27, B42, HLA Class 1 B13, B62, B15, HLA Class I B44, B75, B17, HLA Class 1 ABC, HLA B27, HLA Class 1 B21, B70, B55, HLA Class 1 B14, HLA Class 1 A34, B71, A26 , MHC TsH 2s p q, HLA Class 1 B17, B35, B44, HLAB, HLA Class 1 Bw4, A9, A32, HLA B7, HLA Class 1 B48, B60) |  | Human Recombinant Proteins from Abnova (HLA-B) |
 Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for HLA-B: | Browse
Antibodies Central at Invitrogen | | Millipore Mono- and Polyclonal Antibodies for the study of HLA-B | | Sigma-Aldrich Antibodies for HLA-B | |
Browse R&D Systems for Antibodies |  | Antibodies from Abcam (HLA Class 1 A30 A31, HLA Class 1 B5, B49, B56, HLA Class I B8, HLA Class 1 B7, B27, B42, HLA Class I B44, B75, B17, HLA Class 1 B13, B62, B15, HLA Class 1 ABC, HLA B27, HLA Class 1 B21, B70, B55, HLA Class 1 A34, B71, A26 , HLA Class 1 B14, MHC TsH 2s p q, HLA Class 1 B17, B35, B44, HLAB, HLA B7, HLA Class 1 Bw4, A9, A32, HLA Class 1 B48, B60), each with their AbpromiseSM | | Monoclonal and Polyclonal Antibodies from Abnova (HLA-B) |  | Novus Biologicals Antibody for HLA-B |
Assays for HLA-B: | Protein
Domains/
Families
for HLA-B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01889
- Graphical View of Domain Structure for InterPro Entry P30460
- Graphical View of Domain Structure for InterPro Entry P30461
- Graphical View of Domain Structure for InterPro Entry P30462
- Graphical View of Domain Structure for InterPro Entry P30464
- Graphical View of Domain Structure for InterPro Entry P30466
- Graphical View of Domain Structure for InterPro Entry P03989
- Graphical View of Domain Structure for InterPro Entry P30685
- Graphical View of Domain Structure for InterPro Entry P18463
- Graphical View of Domain Structure for InterPro Entry Q95365
- Graphical View of Domain Structure for InterPro Entry P30475
- Graphical View of Domain Structure for InterPro Entry Q04826
- Graphical View of Domain Structure for InterPro Entry P30479
- Graphical View of Domain Structure for InterPro Entry P30480
- Graphical View of Domain Structure for InterPro Entry P30481
- Graphical View of Domain Structure for InterPro Entry P30483
- Graphical View of Domain Structure for InterPro Entry P30484
- Graphical View of Domain Structure for InterPro Entry P30485
- Graphical View of Domain Structure for InterPro Entry P30486
- Graphical View of Domain Structure for InterPro Entry P30487
- Graphical View of Domain Structure for InterPro Entry P30488
- Graphical View of Domain Structure for InterPro Entry P18464
- Graphical View of Domain Structure for InterPro Entry P30490
- Graphical View of Domain Structure for InterPro Entry P30491
- Graphical View of Domain Structure for InterPro Entry P30492
- Graphical View of Domain Structure for InterPro Entry P30493
- Graphical View of Domain Structure for InterPro Entry P30495
- Graphical View of Domain Structure for InterPro Entry P18465
- Graphical View of Domain Structure for InterPro Entry P10319
- Graphical View of Domain Structure for InterPro Entry Q29940
- Graphical View of Domain Structure for InterPro Entry Q29836
- Graphical View of Domain Structure for InterPro Entry Q31612
- Graphical View of Domain Structure for InterPro Entry P30498
- Graphical View of Domain Structure for InterPro Entry Q31610
- Graphical View of Domain Structure for InterPro Entry Q29718
ProtoNet protein and cluster: P01889 3 Blocks protein families: IPB001039 MHC class I signature IPB003597 Immunoglobulin C-type IPB010579 MHC_I
UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B08_HUMAN, P30460Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B13_HUMAN, P30461Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B14_HUMAN, P30462Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B15_HUMAN, P30464Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B18_HUMAN, P30466Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B27_HUMAN, P03989Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B35_HUMAN, P30685Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B37_HUMAN, P18463Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B38_HUMAN, Q95365Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B39_HUMAN, P30475Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B40_HUMAN, Q04826Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B41_HUMAN, P30479Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B42_HUMAN, P30480Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B44_HUMAN, P30481Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B45_HUMAN, P30483Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B46_HUMAN, P30484Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B47_HUMAN, P30485Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B48_HUMAN, P30486Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B49_HUMAN, P30487Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B50_HUMAN, P30488Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B51_HUMAN, P18464Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B52_HUMAN, P30490Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B53_HUMAN, P30491Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B54_HUMAN, P30492Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B55_HUMAN, P30493Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B56_HUMAN, P30495Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B57_HUMAN, P18465Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B58_HUMAN, P10319Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B59_HUMAN, Q29940Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B67_HUMAN, Q29836Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B73_HUMAN, Q31612Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B78_HUMAN, P30498Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B81_HUMAN, Q31610Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain | Gene Function
for HLA-B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC013187
 Applied Biosystems Silencer® siRNAs for HLA-B
Sigma-Aldrich siRNA for HLA-B
Sigma-Aldrich shRNA for HLA-B
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005514
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005514
untagged cDNA clones in CMV expression vector (see all 2): BC013187
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_005514
UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B08_HUMAN, P30460Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B13_HUMAN, P30461Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B14_HUMAN, P30462Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B15_HUMAN, P30464Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B18_HUMAN, P30466Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B27_HUMAN, P03989Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B35_HUMAN, P30685Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B37_HUMAN, P18463Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B38_HUMAN, Q95365Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B39_HUMAN, P30475Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B40_HUMAN, Q04826Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B41_HUMAN, P30479Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B42_HUMAN, P30480Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B44_HUMAN, P30481Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B45_HUMAN, P30483Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B46_HUMAN, P30484Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B47_HUMAN, P30485Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B48_HUMAN, P30486Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B49_HUMAN, P30487Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B50_HUMAN, P30488Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B51_HUMAN, P18464Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B52_HUMAN, P30490Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B53_HUMAN, P30491Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B54_HUMAN, P30492Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B55_HUMAN, P30493Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B56_HUMAN, P30495Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B57_HUMAN, P18465Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B58_HUMAN, P10319Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B59_HUMAN, Q29940Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B67_HUMAN, Q29836Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B73_HUMAN, Q31612Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B78_HUMAN, P30498Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B81_HUMAN, Q31610Function: Involved in the presentation of foreign antigens to the immune systemUniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718Function: Involved in the presentation of foreign antigens to the immune systemGenatlas biochemistry entry for HLA-B:HLA-B,beta chain,44kDa,class Ia (see MHC1)2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for HLA-B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/13 Sigma-Aldrich "Your Favorite Gene" Pathways for HLA-B (Your Favorite Gene powered by Ingenuity) (see all 13
)
Gene Network CentralTM Interacting Genes and Proteins Network for HLA-B
5/16 Interacting proteins for HLA-B (P306851, 2 P184641, 2 P039891, 2 P304601, 2 P304911, 2 P018891, 2 P304801, 2 P304611, 2 P304811, 2) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds
for HLA-B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HLA-B
10/42  Novoseek chemical compound relationships for HLA-B gene (see all 42
)
About this table
1 PharmGKB drug compound relationship for HLA-B gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| abacavir | CO GN | 15247625 | About this table
|
Transcripts
for HLA-B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC013187
Sigma-Aldrich siRNA for HLA-B
Sigma-Aldrich shRNA for HLA-B
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_005514 REFSEQ mRNAs for HLA-B gene: NM_005514.6
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005514
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005514
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005514
untagged cDNA clones in CMV expression vector (see all 2): BC013187
Additional cDNA sequence: AJ506054.1 AY102648.1 EU048339.1 V00527.1 24/226 DOTS entries (see all 226
): DT.100654997 DT.91783947 DT.91783902 DT.100046073 DT.91883296 DT.97870097 DT.100850152 DT.91798390 DT.91867091 DT.91921040 DT.91985759 DT.95332054 DT.91645158 DT.95331727 DT.453586 DT.100046076 DT.100867489 DT.100850220 DT.87002539 DT.95331865 DT.97870116 DT.121310237 DT.100872504 DT.95331852 24/792 AceView cDNA sequences (see all 792
):Y13567 M64259 NM_005514 CR621734 U29057 BQ053032 L47338 BF757472 BM917124 T98139 M32317 CN480959 BM917823 BM917649 M64255 AF436098 AW973441 X91749 BG744206 BX090262 CD620591 M64257 AA352651 AW820400
 highest scoring ESTs for HLA-B:AF189017 AF436098 AL540609 AW583556 AY007140 BG327758 BG743923 BG744151 BG744206 BG744477 Unigene Clusters for HLA-B: Major histocompatibility complex, class I, B Hs.77961 [show with all ESTs], Hs.707171 [show with all ESTs]Unigene Representative Sequences: AK124160, BX425095
GeneLoc Exon Structure
|
Expression
for HLA-B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HLA-B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HLA-B
1 / 2 / 3 8 probe-sets matching HLA-B gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.77961 Hs.707171
Expression variation in blood from EXPOLDB for HLA-B |
Orthologs
for HLA-B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HLA-B gene from 3 species
About this table Species with no ortholog for HLA-B | Paralogs
for HLA-B(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for HLA-B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718Polymorphism: The following alleles of B-7 are known: B*0702 (B7.2), B*0703 (BPOT), B*0704, B*0705,
B*0706 (B7_L79), B*0718 and B*0724. The sequence shown is B*0702Polymorphism: The following alleles of B-8 are known: B*0801, B*0804, B*0806, B*0807 (B*NV), B*0809
(B*HM; B*08HO), B*0810, B*0812, B*0813 and B*0814. The sequence shown is B*0801Polymorphism: The following alleles of B-13 are known: B*1301 (B13.1), B*1302 (B13.2), B*1304 and
B*1308. The sequence shown is that of B*1302Polymorphism: The following alleles of B-14 are known: B*1401 (Bw-64; B-64), B*1402 (Bw-65, B-65)
and B*1403. The sequence shown is that of B*1401Polymorphism: The following alleles of B-15 are known: B*1501 (Bw-62; B-62), B*1502 (Bw-75, B-75),
B*1503 (Bw-72; B-72; B-70) B*1504, B*1511, B*1519 and B*1566. Allele B*1502 is associated with
susceptibility to Stevens-Johnson syndrome. The sequence shown is that of B*1501Polymorphism: The following alleles of B-18 are known: B*1801 B*1802, B*1803, B*1807 (B*MF),
B*1810, B*1811, B*1812 and B*1813. The sequence shown is that of B*1801Polymorphism: The following alleles of B-27 are known: B*2701=B*2705, B*2702 (B27.2; B-27k; B27e),
B*2703 (B27d), B*2704, B*2706, B*2707, B*2708 (B7Qui) and B*2709 (B27-ci). The sequence shown is
that of B*2701Polymorphism: The following alleles of B-35 are known: B*3501, B*3502, B*3503, B*3504, B*3505
(B35-G), B*3506 (B35-K), B*3507, B*3508, B*3525, B*3528, B*3529 (B*KG), B*3530, B*3532 (B*TMUL)
and B*3536. The sequence shown is that of B*3501Polymorphism: The following alleles of B-37 are known: B*3701, B*3704 and B*3705. The sequence
shown is that of B*3701Polymorphism: The following alleles of B-38 are known: B*3801, B*3802, B*3803, B*3804, B*3805,
B*3806, B*3807 and B*3808. The sequence shown is that of B*3801Polymorphism: The following alleles of B-39 are known: B*3901 (B39.1), B*3902 (B9.2), B*3903,
B*3904 (B39N), B*3905 (ST-16), B*3906 (B39G), B*3907 (B39uw3), B*3909, B*3910, B*3912 (B3901v),
B*3923 (B39022v1) and B*3924. The sequence shown is that of B*3901Polymorphism: The following alleles of B-40 are known: B*4001, B*4002, B*4003 (B40-G1), B*4004
(B40-G2), B*4005 (BN21), B*4006, B*4008, B*4009, B*4016 and B*4027. The sequence shown is that of
B*4002Polymorphism: The following alleles of B-41 are known: B*4101, B*4102 (B41.2), B*4103, B*4104 and
B*4105. The sequence shown is that of B*4101Polymorphism: The following alleles of B-42 are known: B*4201 (Bw-42) and B*4202. The sequence
shown is that of B*4201Polymorphism: The following alleles of B-44 are known: B*4402 (B-12; B44.2), B*4404, B*4405,
B*4407, B*4408 (B44BO), B*4409, B*4412 and B*4413. The sequence shown is that of B*4402Polymorphism: The following alleles of B-45 are known: B*4501 (B-12), B*4503 and B*4504. The
sequence shown is that of B*4501Polymorphism: The following alleles of B-46 are known: B*4601 and B*4602. The sequence shown is
that of B*4601Polymorphism: The following alleles of B-47 are known: B*4701, B*4702 and B*4703. The sequence
shown is that of B*4701Polymorphism: The following alleles of B-48 are known: B*4801 and B*4803. The sequence shown is
that of B*4801Polymorphism: The following alleles of B-49 are known: B*4901, B*4902 and B*4903 (B*RA). The
sequence shown is that of B*4901Polymorphism: The following alleles of B-50 are known: B*5001, B*5002 (B*45ZJ; B50IM) and B*5004.
The sequence shown is that of B*5001Polymorphism: The following alleles of B-51 are known: B*5101, B*5103, B*5104, B*5108 and B*5124.
The sequence shown is that of B*5101Polymorphism: The following alleles of B-52 are known: B*5201, B*5202 (B*52012V) and B*5203. The
sequence shown is that of B*5201Polymorphism: The following alleles of B-53 are known: B*5301, B*5302, B*5303, B*5304, B*5305,
B*5306 and B*5307. The sequence shown is that of B*5301Polymorphism: The following alleles of B-54 are known: B*5401 and B*5402 (B5401V). The sequence
shown is that of B*5401Polymorphism: The following alleles of B-55 are known: B*5501, B*5502, B*5504 (B55.2), B*5505,
B*5508 (B*ER), B*5509 and B*5512. The sequence shown is that of B*5501Polymorphism: The following alleles of B-56 are known: B*5601, B*5602, B*5603 (B22N), B*5604,
B*5605 (B56V1), B*5606 and B*5607. The sequence shown is that of B*5601Polymorphism: The following alleles of B-57 are known: B*5701, B*5702 (Bw57.2), B*5703 (B-57SAU)
and B*5705. The sequence shown is that of B*5701Polymorphism: The following alleles of B-58 are known: B*5801, B*5802, B*5804 and B*5805. The
sequence shown is that of B*5801Polymorphism: The following alleles of B-67 are known: B*6701 (B-67LAV) and B*6702. The sequence
shown is that of B*6701Polymorphism: The following alleles of B-78 are known: B*7801 (B SNA), B*7802 and B*7803. The
sequence shown is that of B*7801Polymorphism: The following alleles of B-82 are known: B*8201 and B*8202. The sequence shown is
that of B*8201
HapMap Linkage Disequilibrium images for HLA-B (up to first 250kb)
|
Disorders & Mutations
for HLA-B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 142830 UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718
Involved in susceptibility to Stevens-Johnson syndrome [MIM:608579]. This is a
life-threatening reaction of the skin to particular types of medication. It is characterized by
high fever, malaise and blistering exanthema. The more severe form of the disease is referred to
as toxic epidermal necrolysis HLA-B27 is associated with the development of ankylosing spondylitis (AS) [MIM:106300]. AS
is a chronic inflammatory rheumatic disease that mainly affects the axial skeleton and is
considered the prototype of seronegative spondyloarthropathies (SNSA), which include reactive
arthritis (e.g., Reiter's syndrome), psoritic spondylitis, and other spondyloarthropathies (SpA).
In the Greek Cypriot population, a restricted number of HLA-B27 subtypes are associated with AS
and other B27-related diseases and an elevated frequency of the B*2702 allele in the AS patients
is identified. The allele B*2707 seems to have a protective role in this population because it was
found only in the healthy controls HLA-B51 is associated with Behcet disease but it is not certain whether HLA-B51 itself or
a closely linked gene is responsible for susceptibility. About 20% of healthy individuals of
various ethnic origin carries the HLA-B 51 locus, compared with 50 to 80% of patients. Behcet
disease is a systemic disorder of recurrent acute inflammation characterized by 4 major symptoms:
oral aphthous ulcers, skin lesions, ocular symptoms and genital ulcerations. Occasionally,
inflammation in tissues and organs throughout the body can occur, including the gastrointestinal
tract, central nervous system, vascular system, lungs, and kidneys. The etiology of Behcet disease
is unclear10/98 Novoseek disease relationships for HLA-B gene (see all 98
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hydatids |
66.23 |
15 |
9226695 (2), 11119517 (1), 15198645 (1), 8479805 (1) (see all 13) |
| hydatid cyst |
61.61 |
34 |
17767016 (4), 16562482 (2), 9236937 (2), 8541895 (2) (see all 23) |
| behcet disease |
55.46 |
25 |
10205273 (4), 8872174 (3), 1356945 (2), 10513813 (2) (see all 13) |
| immunodeficiency |
54.79 |
46 |
12885919 (2), 12414957 (2), 1316930 (1), 11208076 (1) (see all 38) |
| myopathies idiopathic inflammatory |
52.83 |
2 |
17616993 (1), 18974565 (1) |
| influenza |
42.62 |
37 |
2378639 (2), 16631409 (2), 16950949 (2), 16303886 (2) (see all 21) |
| tetanus |
36.41 |
4 |
10886393 (1), 14654644 (1), 8145033 (1), 7973459 (1) |
| myositis |
36.29 |
10 |
16224250 (5), 17360184 (2), 16224247 (1), 18534849 (1) |
| melanoma |
35.43 |
30 |
11251973 (4), 11132148 (3), 7912108 (1), 7836932 (1) (see all 21) |
| tumors |
33.45 |
64 |
1563985 (2), 9537592 (2), 10075583 (2), 2086062 (1) (see all 53) |
About this table
Human Gene Mutation Database: HLA-B
Genetic Association Database: HLA-B
Human Genome Epidemiology Navigator: HLA-B (2256 documents)
|
Medical News
for HLA-B(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for HLA-B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1630 PubMed articles for HLA-B gene (see all 1630
):- Hla-B genotype in Japanese patients with Crohn's disease. (PubMed id 14530653)1, 3, 6 Kinouchi Y....Shimosegawa T. (2003)
- Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population. (PubMed id 15304009)1, 3, 6 Feng M.L....Qian K.C. (2004)
- Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B. (PubMed id 11118029)1, 3, 6 Nejentsev S....Ilonen J. (2000)
- Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. (PubMed id 15784466)1, 3, 6 Lopez-Vazquez A....Lopez-Larrea C. (2005)
- [Comparative studies of serological typing and HLA-A, B antigen genotyping with PCR using sequence-specific primers] (PubMed id 15567775)1, 3, 6 Wu D.L....Tang H. (2004)
- HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (PubMed id 15902698)1, 3, 6 Dorak M.T....Kaslow R.A. (2005)
- Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. (PubMed id 14567462)1, 3, 6 Neri T.M....Okolicsanyi L. (2003)
- Analysis of microsatellite polymorphism around the HLA-B locus in Iranian patients with Behcet's disease. (PubMed id 12492815)1, 3, 6 Mizuki N....Inoko H. (2002)
- Association of HLA class I alleles with aloplecia areata in Chinese Hans. (PubMed id 16185849)3, 6 Xiao F.L....Zhang X.J. (2006)
- HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis. (PubMed id 16365741)3, 6 Campillo J.A....Alvarez-Lopez M.R. (2006)
|
Search for HLA-B
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for HLA-B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
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(HLA Class 1 A30 A31, HLA Class 1 B5, B49, B56, HLA Class I B8, HLA Class 1 B7, B27, B42, HLA Class I B44, B75, B17, HLA Class 1 B13, B62, B15, HLA Class 1 ABC, HLA B27, HLA Class 1 B21, B70, B55, HLA Class 1 A34, B71, A26 , HLA Class 1 B14, MHC TsH 2s p q, HLA Class 1 B17, B35, B44, HLAB, HLA B7, HLA Class 1 Bw4, A9, A32, HLA Class 1 B48, B60) | | | Antibodies (HLA Class 1 A30 A31, HLA Class 1 B5, B49, B56, HLA Class I B8, HLA Class 1 B7, B27, B42, HLA Class I B44, B75, B17, HLA Class 1 B13, B62, B15, HLA Class 1 ABC, HLA B27, HLA Class 1 B21, B70, B55, HLA Class 1 A34, B71, A26 , HLA Class 1 B14, MHC TsH 2s p q, HLA Class 1 B17, B35, B44, HLAB, HLA B7, HLA Class 1 Bw4, A9, A32, HLA Class 1 B48, B60) |
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