Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-B Gene

protein-coding   GIFtS: 63
GCID: GC06M031321

major histocompatibility complex, class I, B

(Previous name: ankylosing spondylitis )
(Previous symbol: AS)
 Explore 305 diseases affiliated with
HLA-B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLA-B    

Aliases
for HLA-B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class I, B1 2     MHC Class I Antigen B*133
AS1 2     MHC Class I Antigen B*143
HLAB2 3     MHC Class I Antigen B*153
SPDA12 5     MHC Class I Antigen B*183
Ankylosing Spondylitis1     MHC Class I Antigen B*273
HLA Class I Histocompatibility Antigen, B Alpha Chain2     MHC Class I Antigen B*353
Leukocyte Antigen Class I-B2     MHC Class I Antigen B*373
Lymphocyte Antigen2     MHC Class I Antigen B*383
MHC Class I Antigen GN001042     MHC Class I Antigen B*393
MHC Class I Antigen HLA-B Heavy Chain2     MHC Class I Antigen B*403
MHC Class I Antigen SHCHA2     MHC Class I Antigen B*413
MHC Class I HLA Heavy Chain2     MHC Class I Antigen B*423
MHC HLA-B Cell Surface Glycoprotein2     MHC Class I Antigen B*443
MHC HLA-B Transmembrane Glycoprotein2     MHC Class I Antigen B*453
B'DT3     MHC Class I Antigen B*463
Bw-223     MHC Class I Antigen B*473
Bw-43     MHC Class I Antigen B*483
Bw-413     MHC Class I Antigen B*493
Bw-443     MHC Class I Antigen B*503
Bw-453     MHC Class I Antigen B*513
Bw-463     MHC Class I Antigen B*523
Bw-473     MHC Class I Antigen B*533
Bw-483     MHC Class I Antigen B*543
Bw-503     MHC Class I Antigen B*553
Bw-523     MHC Class I Antigen B*563
Bw-533     MHC Class I Antigen B*573
Bw-543     MHC Class I Antigen B*583
Bw-553     MHC Class I Antigen B*593
Bw-563     MHC Class I Antigen B*673
Bw-573     MHC Class I Antigen B*73
Bw-583     MHC Class I Antigen B*733
Bw-603     MHC Class I Antigen B*783
HLA Class I Histocompatibility Antigen, B-12 Alpha Chain3     MHC Class I Antigen B*83
HLA Class I Histocompatibility Antigen, B-21 Alpha Chain3     MHC Class I Antigen B*813
HLA Class I Histocompatibility Antigen, B-5 Alpha Chain3     MHC Class I Antigen B*823

External Ids:    HGNC: 49321   Entrez Gene: 31062   Ensembl: ENSG000002347457   OMIM: 1428305   UniProtKB: P018893   
UniProtKB: P304603   UniProtKB: P304613   UniProtKB: P304623   UniProtKB: P304643   UniProtKB: P304663   
UniProtKB: P039893   UniProtKB: P306853   UniProtKB: P184633   UniProtKB: Q953653   UniProtKB: P304753   
UniProtKB: Q048263   UniProtKB: P304793   UniProtKB: P304803   UniProtKB: P304813   UniProtKB: P304833   
UniProtKB: P304843   UniProtKB: P304853   UniProtKB: P304863   UniProtKB: P304873   UniProtKB: P304883   
UniProtKB: P184643   UniProtKB: P304903   UniProtKB: P304913   UniProtKB: P304923   UniProtKB: P304933   
UniProtKB: P304953   UniProtKB: P184653   UniProtKB: P103193   UniProtKB: Q299403   UniProtKB: Q298363   
UniProtKB: Q316123   UniProtKB: P304983   UniProtKB: Q316103   UniProtKB: Q297183   

Export aliases for HLA-B gene to outside databases

Previous GC identifers: GC06M031376 GC06M031426 GC06M031342 GC06M031429 GC06M031345 GC06M031112


Summaries
for HLA-B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-B:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy
chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a
central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are
expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes
the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the
alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms
within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for
these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been
described. (provided by RefSeq, Jul 2008)

UniProtKB/ace: 1B07_HUMAN, P01889 (see all)
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-B


Genomic Views
for HLA-B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167246.1  NT_167247.1  NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-B gene promoter:
         USF1   ISGF-3   Pax-5   AML1a   p300   AP-2gamma   POU2F1   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-B promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HLA-B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031321:  view genomic region     (about GC identifiers)

Start:
 31,321,649 bp from pter      End:
 31,324,989 bp from pter
Size:
 3,341 bases      Orientation:
 minus strand

5 alternative locations:
Chr6-,ALT_REF_LOCI_4 31,287,763-31,291,103      Chr6-,ALT_REF_LOCI_5 31,312,852-31,316,205      Chr6-,ALT_REF_LOCI_6 31,311,768-31,350,689     
Chr6-,ALT_REF_LOCI_2 31,312,134-31,354,661      Chr6-,ALT_REF_LOCI_7 31,244,873-31,248,213     

Proteins
for HLA-B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, B-7 alpha chain precursor  
Size: 362 amino acids; 40460 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity). Interacts with HTLV-1 accessory protein p12I
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for HLA-B:
3VCL (3D)    
Secondary accessions: Q29638 Q29681 Q29854 Q29861 Q31613 Q5SRJ2 Q9GIX1 Q9TP95

UniProtKB/Swiss-Prot: 1B08_HUMAN, P30460 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-8 alpha chain precursor  
Size: 362 amino acids; 40331 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
6/10 PDB 3D structures from and Proteopedia for HLA-B (see all 10):
1AGB (3D)        1AGC (3D)        1AGD (3D)        1AGE (3D)        1AGF (3D)        1M05 (3D)    
Secondary accessions: O62901 O95730 O98140 P79542 Q95369 Q95J00 Q9GJ20 Q9MY78 Q9MYF4 Q9TQH6 Q9TQM2
Q9UQT0

UniProtKB/Swiss-Prot: 1B13_HUMAN, P30461 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-13 alpha chain precursor  
Size: 362 amino acids; 40474 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02956 O78180 Q29661 Q29933 Q9GIY5

UniProtKB/Swiss-Prot: 1B14_HUMAN, P30462 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-14 alpha chain precursor  
Size: 362 amino acids; 40358 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02862 P30463

UniProtKB/Swiss-Prot: 1B15_HUMAN, P30464 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-15 alpha chain precursor  
Size: 362 amino acids; 40388 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
3 PDB 3D structures from and Proteopedia for HLA-B:
1XR8 (3D)        1XR9 (3D)        3C9N (3D)    
Secondary accessions: B0V0B8 P30465 P30513 Q29633 Q29636 Q29829 Q29953 Q29982 Q95343 Q95344 Q9BD06

UniProtKB/Swiss-Prot: 1B18_HUMAN, P30466 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-18 alpha chain precursor  
Size: 362 amino acids; 40275 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O62897 Q29845 Q5JP37 Q9BCM6 Q9GJ23 Q9MY84 Q9MYC7 Q9TP37 Q9TQH7

UniProtKB/Swiss-Prot: 1B27_HUMAN, P03989 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-27 alpha chain precursor  
Size: 362 amino acids; 40428 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
6/29 PDB 3D structures from and Proteopedia for HLA-B (see all 29):
1HSA (3D)        1JGD (3D)        1JGE (3D)        1K5N (3D)        1OF2 (3D)        1OGT (3D)    
Secondary accessions: O19692 P10317 P10318 P19373 P30467 Q08136 Q29693 Q29846 Q29961

UniProtKB/Swiss-Prot: 1B35_HUMAN, P30685 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-35 alpha chain precursor  
Size: 362 amino acids; 40455 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
6/35 PDB 3D structures from and Proteopedia for HLA-B (see all 35):
1A1N (3D)        1A9B (3D)        1A9E (3D)        1CG9 (3D)        1XH3 (3D)        1ZHK (3D)    
Secondary accessions: O62919 P30468 P30469 P30470 P30471 P30472 P30473 P30474 Q9GJM7 Q9TPV2 Q9TQH3
Q9TQH9 Q9TQN4 Q9TQN6

UniProtKB/Swiss-Prot: 1B37_HUMAN, P18463 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-37 alpha chain precursor  
Size: 362 amino acids; 40456 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19627 Q546L8 Q95HA3 Q95HA8 Q95HM9 Q9GJ31

UniProtKB/Swiss-Prot: 1B38_HUMAN, Q95365 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-38 alpha chain precursor  
Size: 362 amino acids; 40416 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19779 O77959 O78160 Q29935 Q29936 Q95IB8 Q95IH5 Q9BCM8 Q9MY92 Q9MYG1 Q9TPT2

UniProtKB/Swiss-Prot: 1B39_HUMAN, P30475 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-39 alpha chain precursor  
Size: 362 amino acids; 40328 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02960 O78217 P30476 P79504 Q29665 Q29697 Q29749 Q29847 Q29852 Q29858 Q8HWF0
Q9TPQ7

UniProtKB/Swiss-Prot: 1B40_HUMAN, Q04826 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-40 alpha chain precursor  
Size: 362 amino acids; 40505 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19556 O19651 P01890 P30477 P30478 Q29762 Q29842 Q29855 Q30173 Q31603 Q9TPT6

UniProtKB/Swiss-Prot: 1B41_HUMAN, P30479 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-41 alpha chain precursor  
Size: 362 amino acids; 40539 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for HLA-B:
3LN4 (3D)        3LN5 (3D)    
Secondary accessions: O19595 Q29848 Q5TK77 Q9MY79 Q9MY94

UniProtKB/Swiss-Prot: 1B42_HUMAN, P30480 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-42 alpha chain precursor  
Size: 362 amino acids; 40333 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: P79555

UniProtKB/Swiss-Prot: 1B44_HUMAN, P30481 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-44 alpha chain precursor  
Size: 362 amino acids; 40481 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
6/20 PDB 3D structures from and Proteopedia for HLA-B (see all 20):
1M6O (3D)        1SYS (3D)        1SYV (3D)        3DX6 (3D)        3DX7 (3D)        3DX8 (3D)    
Secondary accessions: P10320 P30482 P79524 Q29850 Q5RIP1 Q860I4 Q861B5 Q9BCM7 Q9MYC3 Q9UQS8

UniProtKB/Swiss-Prot: 1B45_HUMAN, P30483 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-45 alpha chain precursor  
Size: 362 amino acids; 40414 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9GIZ0 Q9MX21

UniProtKB/Swiss-Prot: 1B46_HUMAN, P30484 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-46 alpha chain precursor  
Size: 362 amino acids; 40440 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9TPR2

UniProtKB/Swiss-Prot: 1B47_HUMAN, P30485 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-47 alpha chain precursor  
Size: 362 amino acids; 40571 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19555 O77933 Q95392 Q9GIL3

UniProtKB/Swiss-Prot: 1B48_HUMAN, P30486 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-48 alpha chain precursor  
Size: 362 amino acids; 40362 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29764

UniProtKB/Swiss-Prot: 1B49_HUMAN, P30487 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-49 alpha chain precursor  
Size: 362 amino acids; 40581 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19625 Q9MY37 Q9MY93

UniProtKB/Swiss-Prot: 1B50_HUMAN, P30488 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-50 alpha chain precursor  
Size: 362 amino acids; 40541 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19615 O19624 O19641 O19783 O46702 O78172 Q9TQG1

UniProtKB/Swiss-Prot: 1B51_HUMAN, P18464 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-51 alpha chain precursor  
Size: 362 amino acids; 40566 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Miscellaneous: There is evidence that HLA-B51 is associated with susceptibility to Behcet disease. However, it is not
certain whether HLA-B51 itself or a closely linked gene is responsible for susceptibility. The world distribution of
HLA-B51 in healthy people corresponds to the global distribution of Behcet disease; in Southern hemisphere countries
(Africa, South Pacific, etc.) and in some parts of Europe, the prevalence of HLA-B51 in healthy people is low or null,
corresponding to a low prevalence of Behcet disease. The wide variation that exists in the relative risk of HLA-B51
would support other nongenetic risk factors
2 PDB 3D structures from and Proteopedia for HLA-B:
1E27 (3D)        1E28 (3D)    
Secondary accessions: O19675 O78173 P30489 Q29851 Q29857 Q96IT9 Q9MY43

UniProtKB/Swiss-Prot: 1B52_HUMAN, P30490 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-52 alpha chain precursor  
Size: 362 amino acids; 40521 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for HLA-B:
3W39 (3D)    
Secondary accessions: Q9MY75 Q9TPT4

UniProtKB/Swiss-Prot: 1B53_HUMAN, P30491 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-53 alpha chain precursor  
Size: 362 amino acids; 40495 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for HLA-B:
1A1M (3D)        1A1O (3D)    
Secondary accessions: O78053 O78138 Q30198 Q5TK76 Q9BD43 Q9GJF0 Q9MY42 Q9TP36 Q9TQH8

UniProtKB/Swiss-Prot: 1B54_HUMAN, P30492 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-54 alpha chain precursor  
Size: 362 amino acids; 40380 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9TPQ9

UniProtKB/Swiss-Prot: 1B55_HUMAN, P30493 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-55 alpha chain precursor  
Size: 362 amino acids; 40496 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O78163 P30494 P79489 P79523 Q8MGQ3 Q9GIZ9 Q9GJ00

UniProtKB/Swiss-Prot: 1B56_HUMAN, P30495 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-56 alpha chain precursor  
Size: 362 amino acids; 40478 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19758 P30496 P79490 Q9GIM3 Q9GJ17 Q9TPR4

UniProtKB/Swiss-Prot: 1B57_HUMAN, P18465 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-57 alpha chain precursor  
Size: 362 amino acids; 40224 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
6/11 PDB 3D structures from and Proteopedia for HLA-B (see all 11):
2BVO (3D)        2BVP (3D)        2BVQ (3D)        2HJL (3D)        2RFX (3D)        2YPK (3D)    
Secondary accessions: O62917 P30497 P79496 Q29679 Q5QT24

UniProtKB/Swiss-Prot: 1B58_HUMAN, P10319 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-58 alpha chain precursor  
Size: 362 amino acids; 40337 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29925 Q9TP35 Q9TPS6

UniProtKB/Swiss-Prot: 1B59_HUMAN, Q29940 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-59 alpha chain precursor  
Size: 362 amino acids; 40584 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02957

UniProtKB/Swiss-Prot: 1B67_HUMAN, Q29836 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-67 alpha chain precursor  
Size: 362 amino acids; 40342 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29678 Q8SNC5 Q95IA6 Q9BD38

UniProtKB/Swiss-Prot: 1B73_HUMAN, Q31612 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-73 alpha chain precursor  
Size: 363 amino acids; 40435 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: G3GN01

UniProtKB/Swiss-Prot: 1B78_HUMAN, P30498 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-78 alpha chain precursor  
Size: 362 amino acids; 40478 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O62915 Q29924 Q546M4

UniProtKB/Swiss-Prot: 1B81_HUMAN, Q31610 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-81 alpha chain precursor  
Size: 362 amino acids; 40400 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein

UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-82 alpha chain precursor  
Size: 362 amino acids; 40421 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q29695 Q29742 Q8MHN4 Q9MY61 Q9MYB8

Explore the universe of human proteins at neXtProt for HLA-B: NX_Q29718

Post-translational modifications:

  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the
    • protein for rapid degradation via the ubiquitin system (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q29718

    • HLA-B Protein expression data from MOPED and PaxDb:    About this image 
    HLA-B Protein Expression
    REFSEQ proteins: NP_005505.2  
    ENSEMBL proteins: 
     ENSP00000399168   ENSP00000392626   ENSP00000405931  
    Reactome Protein details: P30492 P30483 P30495 Q31610 P30491 P18465 P18464 Q29718 Q29836 P30464 P30480 Q31612 P30490 P30498 P30460 P30484 P30487 P18463 P30462 P30685 P30488 P01889 P30493 P10319 P03989 Q29940 P30466 P30475 Q95365 P30461 Q04826 P30485 P30481 P30479
    Human Recombinant Protein Products for HLA-B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HLA-B
    OriGene Protein Over-expression Lysate: HLA-B
    OriGene Custom Protein Services for HLA-B 
    GenScript Custom Purified and Recombinant Proteins Services for HLA-B
    Novus Biologicals HLA-B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HLA-B

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS518865
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0016020membrane TAS3011411

    HLA-B for ontologies           About GeneDecksing



    HLA-B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-B
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): HLA-B
    OriGene Custom Antibody Services for HLA-B 
    GenScript Custom Superior Antibodies Services for HLA-B
    Novus Biologicals HLA-B Antibodies
    Abcam antibodies for HLA-B (P30492, P30483, P30495, Q31610, P30491, P18465, P18464, Q29718, Q29836, P30464, P30480, Q31612, P30490, P30498, P30460, P30484, P30487, P18463, P30462, P30685, P30488, P01889, P30493, P10319, P03989, Q29940, P30466, P30475, Q95365, P30461, Q04826, P30486, P30485, P30481, P30479) 
    Uscn Antibodies for HLA-B
    Search ThermoFisher Antibodies for HLA-B

    Assay Products for HLA-B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HLA-B

    Protein Domains /
    Families
    for HLA-B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLA-B for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01889
    Graphical View of Domain Structure for InterPro Entry P30460
    Graphical View of Domain Structure for InterPro Entry P30461
    Graphical View of Domain Structure for InterPro Entry P30462
    Graphical View of Domain Structure for InterPro Entry P30464
    Graphical View of Domain Structure for InterPro Entry P30466
    Graphical View of Domain Structure for InterPro Entry P03989
    Graphical View of Domain Structure for InterPro Entry P30685
    Graphical View of Domain Structure for InterPro Entry P18463
    Graphical View of Domain Structure for InterPro Entry Q95365
    Graphical View of Domain Structure for InterPro Entry P30475
    Graphical View of Domain Structure for InterPro Entry Q04826
    Graphical View of Domain Structure for InterPro Entry P30479
    Graphical View of Domain Structure for InterPro Entry P30480
    Graphical View of Domain Structure for InterPro Entry P30481
    Graphical View of Domain Structure for InterPro Entry P30483
    Graphical View of Domain Structure for InterPro Entry P30484
    Graphical View of Domain Structure for InterPro Entry P30485
    Graphical View of Domain Structure for InterPro Entry P30486
    Graphical View of Domain Structure for InterPro Entry P30487
    Graphical View of Domain Structure for InterPro Entry P30488
    Graphical View of Domain Structure for InterPro Entry P18464
    Graphical View of Domain Structure for InterPro Entry P30490
    Graphical View of Domain Structure for InterPro Entry P30491
    Graphical View of Domain Structure for InterPro Entry P30492
    Graphical View of Domain Structure for InterPro Entry P30493
    Graphical View of Domain Structure for InterPro Entry P30495
    Graphical View of Domain Structure for InterPro Entry P18465
    Graphical View of Domain Structure for InterPro Entry P10319
    Graphical View of Domain Structure for InterPro Entry Q29940
    Graphical View of Domain Structure for InterPro Entry Q29836
    Graphical View of Domain Structure for InterPro Entry Q31612
    Graphical View of Domain Structure for InterPro Entry P30498
    Graphical View of Domain Structure for InterPro Entry Q31610
    Graphical View of Domain Structure for InterPro Entry Q29718

    ProtoNet protein and cluster: P01889

    3 Blocks protein families:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B08_HUMAN, P30460
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B13_HUMAN, P30461
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B14_HUMAN, P30462
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B15_HUMAN, P30464
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B18_HUMAN, P30466
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B27_HUMAN, P03989
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B35_HUMAN, P30685
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B37_HUMAN, P18463
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B38_HUMAN, Q95365
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B39_HUMAN, P30475
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B40_HUMAN, Q04826
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B41_HUMAN, P30479
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B42_HUMAN, P30480
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B44_HUMAN, P30481
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B45_HUMAN, P30483
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B46_HUMAN, P30484
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B47_HUMAN, P30485
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B48_HUMAN, P30486
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B49_HUMAN, P30487
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B50_HUMAN, P30488
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B51_HUMAN, P18464
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B52_HUMAN, P30490
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B53_HUMAN, P30491
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B54_HUMAN, P30492
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B55_HUMAN, P30493
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B56_HUMAN, P30495
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B57_HUMAN, P18465
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B58_HUMAN, P10319
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B59_HUMAN, Q29940
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B67_HUMAN, Q29836
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B73_HUMAN, Q31612
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B78_HUMAN, P30498
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B81_HUMAN, Q31610
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for HLA-B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:
    UniProtKB/ace Summary: 1B07_HUMAN, P01889 (see all)
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-B:
    HLA-B,beta chain,44kDa,class Ia (see MHC1)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0032393MHC class I receptor activity NAS518865
         
    HLA-B for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for H2-D1):
     behavior/neurological  cellular  hematopoietic system  immune system  mortality/aging 
     nervous system  no phenotypic analysis 

    HLA-B for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out H2-D1H2-tm1Bpe for HLA-B
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HLA-B 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HLA-B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-B
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HLA-B:
    hsa-miR-1299 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-B
    OriGene shRNA RFP: HLA-B
    OriGene siRNA: HLA-B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-B
    Sirion Biotech Custom design and validation of potent shRNA sequences against HLA-B 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HLA-B
    Sirion Biotech Customized adenovirus for overexpression of HLA-B 
    Sirion Biotech Customized adenovirus for potent knockdown of HLA-B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-B
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-B (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HLA-B (NM_005514)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HLA-B
    Search LifeMap BioReagents cell lines for HLA-B
    Sirion Biotech Customized stable knockdown cell line services for HLA-B 
    Sirion Biotech Customized inducible knockdown cell line services for HLA-B
    Sirion Biotech Customized stable overexpressing cell line services for HLA-B
    Sirion Biotech Customized inducible overexpressing cell line services for HLA-B

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-B


    Pathways & Interactions
    for HLA-B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of peptide bound MHC class I complex to cell surface
    		Translocation of peptide bound MHC class I complex to cell surface1.00
    		Endosomal/Vacuolar pathway0.78
    		Journey of cargo through Golgi complex1.00
    		Peptide loading on MHC class I in phagosome0.70
    		Expression of peptide bound class I MHC on cell surface1.00
    		Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.28
    		Export of peptide loaded MHC class I complex to PM1.00
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    3Ubiquitinated Orc1 is degraded by the proteasome
    		ER-Phagosome pathway0.74
    		Proteasome Degradation0.56
    		Antigen processing-Cross presentation0.60
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    5Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HLA-B
        Immune response Antigen presentation by MHC class I
    Immune response Role of DAP12 receptors in NK cells

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-B
        CDC42 Pathway
    CTL Mediated Apoptosis

    2 GeneGo (Thomson Reuters) Pathways for HLA-B
        Immune response Antigen presentation by MHC class I
    Immune response Role of DAP12 receptors in NK cells

    2 BioSystems Pathways for HLA-B 
        Type II interferon signaling (IFNG)
    Proteasome Degradation

    5/21        Reactome Pathways for HLA-B (see all 21)
        Endosomal/Vacuolar pathway
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Interferon alpha/beta signaling
    Expression of IFN-induced genes
    ER-Phagosome pathway


    5/10         Kegg Pathways  (Kegg details for HLA-B) (see all 10):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    HLA-B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/113 Interacting proteins for HLA-B (P039892 P304602 P304912 P304612 P184642 P306852 P018892 Q316122, 3 P304812, 3 ENSP000003991684) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617692, ENSP000003408584MINT-25080 STRING: ENSP00000340858
    ATF7IPQ6VMQ62MINT-61906
    VIPR1P322412MINT-8144492
    CD8AENSP000002836354STRING: ENSP00000283635
    CSF1ENSP000003275134STRING: ENSP00000327513
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0002667regulation of T cell anergy IMP--
    GO:0006952defense response TAS3011411

    HLA-B for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLA-B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-B

    1 HMDB Compound for HLA-B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glycerylphosphorylethanolamine2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)1190-00-7--

    1 DrugBank Compound for HLA-B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Formylmethionine-- --target--10592235

    10/73 Novoseek chemical compound relationships for HLA-B gene (see all 73)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    listeriolysin 38.8 1 7589099 (1)
    solium 30.8 3 8295903 (1), 17210192 (1)
    2',5'-oligoadenylate 29.6 1 10074208 (1)
    castanospermine 16.9 1 8440676 (1)
    polyinosinic-polycytidylic acid 15.4 1 17063122 (1)
    glycolipid 14.1 1 15857311 (1)
    3beta-hydroxysteroid 11.4 2 19036885 (1), 8288710 (1)
    phycoerythrin 10.4 2 1764978 (1)
    udpglucose 10.1 2 18202596 (1), 12198488 (1)
    chlorzoxazone 8.03 1 9186495 (1)

    5 PharmGKB related drug/compound annotations for HLA-B gene    About this table
    Drug/compound PharmGKB Annotation
    abacavirCA  DG  DL  
    allopurinolCA  DG  
    carbamazepineCA  DL  
    phenytoinCA  DL  
    ribavirinDG  
    Search CenterWatch for drugs/clinical trials and news about HLA-B / 1B82 

    Transcripts
    for HLA-B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLA-B gene: 
    NM_005514.6  

    Unigene Clusters for HLA-B:

    Major histocompatibility complex, class I, B
    Hs.77961  [show with all ESTs], Hs.654404  [show with all ESTs]
    Unigene Representative Sequences: AK124160, BF526307
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481849 ENST00000497377 ENST00000412585(uc003ntg.1 uc003nth.2 uc003nti.1)
    ENST00000463574 ENST00000426590(uc010jsn.1) ENST00000498007 ENST00000434333(uc003ntf.2)
    ENST00000474381(uc010jso.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HLA-B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-B
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HLA-B:
    hsa-miR-1299 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-B
    OriGene shRNA RFP: HLA-B
    OriGene siRNA: HLA-B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-B
    Sirion Biotech Custom design and validation of potent shRNA sequences against HLA-B 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-B
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-B (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HLA-B (NM_005514)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HLA-B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-B

    Additional cDNA sequence: 

    J00192.1 M64254.1 M64258.1 X07061.1 

    24/224 DOTS entries (see all 224):

    DT.100654997  DT.91783947  DT.91783902  DT.100046073  DT.91883296  DT.91798390  DT.100850152  DT.97870097 
    DT.91867091  DT.91921040  DT.91985759  DT.91645158  DT.95332054  DT.95331727  DT.453586  DT.100046076 
    DT.100850220  DT.100867489  DT.87002539  DT.95331865  DT.97870116  DT.121310237  DT.95331852  DT.100872504 

    24/792 AceView cDNA sequences (see all 792):

    M32317 M64255 AW973441 X91749 BQ053032 CN480959 BM917823 Y13567 
    U29057 L47338 BM917124 BM917649 NM_005514 AF436098 BF757472 T98139 
    M64259 CR621734 BX411653 AW820412 BG744477 U34810 BV204206 U21052 

    GeneLoc Exon Structure


    Expression
    for HLA-B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    HLA-B Expression
    About this image

    HLA-B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HLA-B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-B

    SOURCE GeneReport for Unigene clusters: Hs.77961 Hs.654404
        SABiosciences Expression via Pathway-Focused PCR Array including HLA-B: 
              Type I Interferon Response in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HLA-B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-B
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-B

    Orthologs
    for HLA-B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-B gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NM79_CHICK6
    --
    (see all 15)    		 --
    		 42(a)
    41(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 16(40458-41204)
    16(204323-205564)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 25)    		 --
    		 47(a)
    46(a)
    (see all 25)    		 many ↔ many
    many ↔ many
    (see all 25)    		 AAWZ02039289(783-2823)
    AAWZ02038573(7605-9645)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01089980.16
    si:ch211-287j19.66
    (see all 7)    		 si:ch211-287j19.6
    (see all 7)    		 26(a)
    25(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 3(502131-512626)
    1(47613228-47619236)


    ENSEMBL Gene Tree for HLA-B (if available)
    TreeFam Gene Tree for HLA-B (if available) 

    Paralogs
    for HLA-B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-B gene
    HLA-F2  MR12  HFE2  FCGRT2  HLA-E2  HLA-C2  HLA-A2  HLA-G2  
    18/148 SIMAP similar genes for HLA-B using alignment to 5507 protein entries:     1B07_HUMAN (see all proteins) (see all similar genes):
    HLA-A*0201V3    HLA-Cw3    HLA-Cw2    B-1510    HLA-B*3512    B-3501
    B*15    B*35    HLA-Bw62.1    HLA-B*35JAC    HLA-ABC    HLA-B*15UL
    HLA-B1501V2    HLA-B27    HLA-Bw62.4    HLA-B*3531    HLA-B*0707    HLA-B*1522

    HLA-B for paralogs           About GeneDecksing



    Genomic Variants
    for HLA-B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718
    Polymorphism: The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06
    (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02
    Polymorphism: The following alleles of B-8 are known: B*08:01, B*08:04, B*08:06, B*08:07 (B*NV), B*08:09 (B*HM;
    B*08HO), B*08:10, B*08:12, B*08:13 and B*08:14. The sequence shown is B*08:01
    Polymorphism: The following alleles of B-13 are known: B*13:01 (B13.1), B*13:02 (B13.2), B*13:04 and B*13:08. The
    sequence shown is that of B*13:02
    Polymorphism: The following alleles of B-14 are known: B*14:01 (Bw-64; B-64), B*14:02 (Bw-65, B-65) and B*14:03. The
    sequence shown is that of B*14:01
    Polymorphism: The following alleles of B-15 are known: B*15:01 (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03 (Bw-72;
    B-72; B-70) B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that of B*15:01
    Polymorphism: The following alleles of B-18 are known: B*18:01 B*18:02, B*18:03, B*18:07 (B*MF), B*18:10, B*18:11,
    B*18:12 and B*18:13. The sequence shown is that of B*18:01
    Polymorphism: The following alleles of B-27 are known: B*27:01=B*27:05, B*27:02 (B27.2; B-27k; B27e), B*27:03 (B27d),
    B*27:04, B*27:06, B*27:07, B*27:08 (B7Qui) and B*27:09 (B27-ci). The sequence shown is that of B*27:01
    Polymorphism: The following alleles of B-35 are known: B*35:01, B*35:02, B*35:03, B*35:04, B*35:05 (B35-G), B*35:06
    (B35-K), B*35:07, B*35:08, B*35:25, B*35:28, B*35:29 (B*KG), B*35:30, B*35:32 (B*TMUL) and B*35:36. The sequence shown
    is that of B*35:01
    Polymorphism: The following alleles of B-37 are known: B*37:01, B*37:04 and B*37:05. The sequence shown is that of
    B*37:01
    Polymorphism: The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07
    and B*38:08. The sequence shown is that of B*38:01
    Polymorphism: The following alleles of B-39 are known: B*39:01 (B39.1), B*39:02 (B9.2), B*39:03, B*39:04 (B39N),
    B*39:05 (ST-16), B*39:06 (B39G), B*39:07 (B39uw3), B*39:09, B*39:10, B*39:12 (B3901v), B*39:23 (B39022v1) and B*39:24.
    The sequence shown is that of B*39:01
    Polymorphism: The following alleles of B-40 are known: B*40:01, B*40:02, B*40:03 (B40-G1), B*40:04 (B40-G2), B*40:05
    (BN21), B*40:06, B*40:08, B*40:09, B*40:16 and B*40:27. The sequence shown is that of B*40:02
    Polymorphism: The following alleles of B-41 are known: B*41:01, B*41:02 (B41.2), B*41:03, B*41:04 and B*41:05. The
    sequence shown is that of B*41:01
    Polymorphism: The following alleles of B-42 are known: B*42:01 (Bw-42) and B*42:02. The sequence shown is that of
    B*42:01
    Polymorphism: The following alleles of B-44 are known: B*44:02 (B-12; B44.2), B*44:04, B*44:05, B*44:07, B*44:08
    (B44BO), B*44:09, B*44:12 and B*44:13. The sequence shown is that of B*44:02
    Polymorphism: The following alleles of B-45 are known: B*45:01 (B-12), B*45:03 and B*45:04. The sequence shown is that
    of B*45:01
    Polymorphism: The following alleles of B-46 are known: B*46:01 and B*46:02. The sequence shown is that of B*46:01
    Polymorphism: The following alleles of B-47 are known: B*47:01, B*47:02 and B*47:03. The sequence shown is that of
    B*47:01
    Polymorphism: The following alleles of B-48 are known: B*48:01 and B*48:03. The sequence shown is that of B*48:01
    Polymorphism: The following alleles of B-49 are known: B*49:01, B*49:02 and B*49:03 (B*RA). The sequence shown is that
    of B*49:01
    Polymorphism: The following alleles of B-50 are known: B*50:01, B*50:02 (B*45ZJ; B50IM) and B*50:04. The sequence shown
    is that of B*50:01
    Polymorphism: The following alleles of B-51 are known: B*51:01, B*51:03, B*51:04, B*51:08 and B*51:24. The sequence
    shown is that of B*51:01
    Polymorphism: The following alleles of B-52 are known: B*52:01, B*52:02 (B*52012V) and B*52:03. The sequence shown is
    that of B*52:01
    Polymorphism: The following alleles of B-53 are known: B*53:01, B*53:02, B*53:03, B*53:04, B*53:05, B*53:06 and
    B*53:07. The sequence shown is that of B*53:01
    Polymorphism: The following alleles of B-54 are known: B*54:01 and B*54:02 (B5401V). The sequence shown is that of
    B*54:01
    Polymorphism: The following alleles of B-55 are known: B*55:01, B*55:02, B*55:04 (B55.2), B*55:05, B*55:08 (B*ER),
    B*55:09 and B*55:12. The sequence shown is that of B*55:01
    Polymorphism: The following alleles of B-56 are known: B*56:01, B*56:02, B*56:03 (B22N), B*56:04, B*56:05 (B56V1),
    B*56:06 and B*56:07. The sequence shown is that of B*56:01
    Polymorphism: The following alleles of B-57 are known: B*57:01, B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05. The
    sequence shown is that of B*57:01
    Polymorphism: The following alleles of B-58 are known: B*58:01, B*58:02, B*58:04 and B*58:05. The sequence shown is
    that of B*58:01. Allele B*58:01 is an important genetic risk factor for severe cutaneous adverse reactions to
    allopurinol in the Han Chinese population [MIM:608579]
    Polymorphism: The following alleles of B-67 are known: B*67:01 (B-67LAV) and B*67:02. The sequence shown is that of
    B*67:01
    Polymorphism: The following alleles of B-78 are known: B*78:01 (B SNA), B*78:02 and B*78:03. The sequence shown is that
    of B*78:01
    Polymorphism: The following alleles of B-82 are known: B*82:01 and B*82:02. The sequence shown is that of B*82:01


    10/1328 NCBI SNPs in HLA-B are shown (see all 1328)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10931,2
    		C,Fhistocompatibility31321906(+) GTCACA/GGTGGA 1 -- ut316Minor allele frequency- G:0.11NA CSA WA 246
    rs10558901,2
    		C,Ahistocompatibility31321915(-) ACCCTT/CGTGTC 1 -- ut314Minor allele frequency- C:0.19NA WA EA 360
    rs10558491,2
    		C,Ahistocompatibility31321916(-) CACCCC/G/TTGTGT 2 -- ut315NA MN WA EA 544
    rs1170071721,2
    		Chistocompatibility31321917(+) CACAAA/GGGTGG 1 -- ut310--------
    rs10558211,2
    		C,Fhistocompatibility31321919(-) GCCCAC/ACTGTG 1 -- ut316Minor allele frequency- A:0.06MN NA CSA WA 427
    rs10496451,2
    		Chistocompatibility31321922(-) ACAGCC/TCACCC 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs571382511,2
    		Chistocompatibility31321926(+) GGCTG-/GTCTCT 1 -- ut310--------
    rs10553481,2
    		Chistocompatibility31321948(-) TTAGCA/CTAATG 1 -- ut315Minor allele frequency- C:0.24NA CSA WA EA 362
    rs10551491,2
    		C,F,Ahistocompatibility31321958(-) TGCGTC/TCCTGT 1 -- ut314Minor allele frequency- T:0.17MN WA NA EA 542
    rs715633141,2
    		Chistocompatibility31321961(+) GGGACG/ACAGAC 1 -- ut314Minor allele frequency- A:0.04NA EA 244

    HapMap Linkage Disequilibrium report for HLA-B (31321649 - 31324989 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for HLA-B
         10 CNVs: 69382 3601 2624 69399 69384 7564 62496 5387 5222 31275
         2 Indels: 33805 69392
    Human Gene Mutation Database (HGMD): HLA-B

    Locus Specific Mutation Databases (LSDB): HLA-B

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-B
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-B

    Disorders / Diseases
    for HLA-B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLA-B for disorders           About GeneDecksing

    OMIM gene information: 142830   
    OMIM disorders: 106300  608579  
    UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718
  • Defects in HLA-B are a cause of susceptibility to Stevens-Johnson syndrome (SJS) [MIM:608579]. A rare
    • blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis.
    Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and
    target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by
    destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface
    area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be
    caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some
    cases. Note=Allele B*15:02 is associated with susceptibility to Stevens-Johnson syndrome
  • Defects in HLA-B are a cause of susceptibility to spondyloarthropathy type 1 (SPDA1) [MIM:106300]. It is a
    • chronic rheumatic disease with multifactorial inheritance. It includes a spectrum of related disorders comprising
    ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis
    associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur
    simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same
    disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the
    prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the
    sacroiliac, intervertebral, and costovertebral joints. Note=In the Greek Cypriot population, a restricted number of
    HLA-B27 subtypes are associated with ankylosing spondylitis and other B27-related diseases and an elevated frequency
    of the B*2702 allele in ankylosing spondylitis patients is identified. The allele B*2707 seems to have a protective
    role in this population because it was found only in the healthy controls

    20/305 diseases for HLA-B (see all 305):    About MalaCards
    stevens-johnson syndrome, carbamazepine-induced    ankylosing spondylitis    21-hydroxylase-deficient congenital adrenal hyperplasia    drug-induced liver injury due to flucloxacillin
    stevens-johnson syndrome    21-hydroxylase deficiency    vogt-koyanagi-harada disease    htlv-1 associated myelopathy
    lambert-eaton myasthenic syndrome    spondylitis    pure red-cell aplasia    pustulosis of palm and sole
    mhc class i deficiency    abacavir hypersensitivity    diffuse idiopathic skeletal hyperostosis    pars planitis
    porphyria cutanea tarda    relapsing-remitting multiple sclerosis    copd, rate of decline of lung function in    churg-strauss syndrome

    18 diseases from the University of Copenhagen DISEASES database for HLA-B:
    Melanoma     Influenza     Vaccinia     Hypersensitivity reaction type II disease
    Uveitis     Vasculitis     Lymphoma     Diabetes mellitus
    Multiple sclerosis     Ankylosing spondylitis     Arthritis     Aphthous stomatitis
    Human immunodeficiency virus infectious disease     Myositis     Hemochromatosis     Carcinoma
    Malaria     Leukemia

    10/96 Novoseek disease relationships for HLA-B gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydatids 66.1 15 9226695 (2), 11119517 (1), 15198645 (1), 8479805 (1) (see all 13)
    hydatid cyst 63.2 37 17767016 (4), 16562482 (2), 9236937 (2), 8541895 (2) (see all 26)
    immunodeficiency 55.9 52 20219903 (2), 12885919 (2), 12414957 (2), 1316930 (1) (see all 42)
    behcet disease 54.6 25 10205273 (4), 8872174 (3), 1356945 (2), 10513813 (2) (see all 13)
    myopathies idiopathic inflammatory 50.6 2 17616993 (1), 18974565 (1)
    influenza 44.3 41 2378639 (2), 16631409 (2), 16950949 (2), 16303886 (2) (see all 23)
    myositis 40.6 10 16224250 (5), 17360184 (2), 16224247 (1), 18534849 (1)
    tetanus 36.5 4 10886393 (1), 14654644 (1), 8145033 (1), 7973459 (1)
    autoimmune diseases 35.5 7 9606177 (1), 12807817 (1), 19743458 (1), 10432437 (1) (see all 6)
    polymyositis 35.4 2 19730931 (1), 11953983 (1)

    Genetic Association Database (GAD): HLA-B
    Human Genome Epidemiology (HuGE) Navigator: HLA-B (2951 documents)

    Export disorders for HLA-B gene to outside databases

    Publications
    for HLA-B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-B gene, integrated from 9 sources (see all 2138):
    (articles sorted by number of sources associating them with HLA-B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Hla-B genotype in Japanese patients with Crohn's disease. (PubMed id 14530653)1, 4, 9 Kinouchi Y....Shimosegawa T. (2003)
    2. Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population. (PubMed id 15304009)1, 4, 9 Feng M.L....Qian K.C. (2004)
    3. Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B. (PubMed id 11118029)1, 4, 9 Nejentsev S....Ilonen J. (2000)
    4. Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. (PubMed id 15784466)1, 4, 9 Lopez-Vazquez A....Lopez-Larrea C. (2005)
    5. [Comparative studies of serological typing and HLA-A, B antigen genotyping with PCR using sequence-specific primers] (PubMed id 15567775)1, 4, 9 Wu D.L....Tang H. (2004)
    6. HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (PubMed id 15902698)1, 4, 9 Dorak M.T....Kaslow R.A. (2005)
    7. Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. (PubMed id 14567462)1, 4, 9 Neri T.M....Okolicsanyi L. (2003)
    8. Analysis of microsatellite polymorphism around the HLA-B locus in Iranian patients with Behcet's disease. (PubMed id 12492815)1, 4, 9 Mizuki N....Inoko H. (2002)
    9. Association of HLA class I alleles with aloplecia areata in Chinese Hans. (PubMed id 16185849)1, 4 Xiao F.L....Zhang X.J. (2006)
    10. HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis. (PubMed id 16365741)1, 4 Campillo J.A....Alvarez-Lopez M.R. (2006)

    External Searches for HLA-B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HLA-B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3106 HGNC: 4932 AceView: HLA-B Ensembl:ENSG00000234745 euGenes: HUgn3106
    ECgene: HLA-B Kegg: 3106 H-InvDB: HLA-B

    Other Databases showing HLA-B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLA-B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HLA-B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-B gene:
    Search GeneIP for patents involving HLA-B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HLA-B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-B
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for HLA-B   OriGene shRNA RFP for HLA-B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-B  
     OriGene Protein Over-expression Lysate for HLA-B   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HLA-B   OriGene 3'-UTR Clone for HLA-B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HLA-B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HLA-B   OriGene Custom Protein Services for HLA-B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-B
     GenScript Custom Purified and Recombinant Proteins Services for HLA-B GenScript cDNA clones with any tag delivered in your preferred vector for HLA-B
     GenScript Custom Assay Services for HLA-B GenScript Custom Superior Antibodies Services for HLA-B
     GenScript Custom overexpressing Cell Line Services for HLA-B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HLA-B promoter
     Search Chromatin IP Primers for HLA-B
     RT2 qPCR Primer Assay in human, mouse, rat HLA-B
     GNC Network for HLA-B
     SABiosciences PCR Arrays including human, mouse, rat HLA-B
     Search Tocris compounds for HLA-B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HLA-B antibodies
     HLA-B lysates
     Antibodies for HLA-B
     See all of Abcam's Antibodies, Kits and Proteins for HLA-B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HLA-B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HLA-B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-B
     SwitchGear 3'UTR luciferase reporter plasmids for HLA-B
     SwitchGear Promoter luciferase reporter plasmids for HLA-B
     Search ThermoFisher Antibodies for HLA-B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-B
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HLA-B
    Sirion Biotech Customized:
     stable knockdown cell line services for HLA-B
     inducible knockdown cell line services for HLA-B
     design and validation of potent shRNA sequences against HLA-B
     adenovirus for potent knockdown of HLA-B
     adenovirus for overexpression of HLA-B
     stable overexpressing cell line services for HLA-B
     inducible overexpressing cell line services for HLA-B
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HLA-B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4