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HLA-B Gene

protein-coding   GIFtS: 65
GCID: GC06M031321

Major Histocompatibility Complex, Class I, B

(Previous name: ankylosing spondylitis)
(Previous symbol: AS)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class I, B1 2     MHC Class I Antigen B*133
AS1 2     MHC Class I Antigen B*143
HLAB2 3     MHC Class I Antigen B*153
SPDA12 5     MHC Class I Antigen B*183
Ankylosing Spondylitis1     MHC Class I Antigen B*273
HLA Class I Histocompatibility Antigen, B Alpha Chain2     MHC Class I Antigen B*353
Leukocyte Antigen Class I-B2     MHC Class I Antigen B*373
Lymphocyte Antigen2     MHC Class I Antigen B*383
MHC Class I Antigen GN001042     MHC Class I Antigen B*393
MHC Class I Antigen HLA-B Heavy Chain2     MHC Class I Antigen B*403
MHC Class I Antigen SHCHA2     MHC Class I Antigen B*413
MHC Class I HLA Heavy Chain2     MHC Class I Antigen B*423
MHC HLA-B Cell Surface Glycoprotein2     MHC Class I Antigen B*443
MHC HLA-B Transmembrane Glycoprotein2     MHC Class I Antigen B*453
B'DT3     MHC Class I Antigen B*463
Bw-223     MHC Class I Antigen B*473
Bw-43     MHC Class I Antigen B*483
Bw-413     MHC Class I Antigen B*493
Bw-443     MHC Class I Antigen B*503
Bw-453     MHC Class I Antigen B*513
Bw-463     MHC Class I Antigen B*523
Bw-473     MHC Class I Antigen B*533
Bw-483     MHC Class I Antigen B*543
Bw-503     MHC Class I Antigen B*553
Bw-523     MHC Class I Antigen B*563
Bw-533     MHC Class I Antigen B*573
Bw-543     MHC Class I Antigen B*583
Bw-553     MHC Class I Antigen B*593
Bw-563     MHC Class I Antigen B*673
Bw-573     MHC Class I Antigen B*73
Bw-583     MHC Class I Antigen B*733
Bw-603     MHC Class I Antigen B*783
HLA Class I Histocompatibility Antigen, B-12 Alpha Chain3     MHC Class I Antigen B*83
HLA Class I Histocompatibility Antigen, B-21 Alpha Chain3     MHC Class I Antigen B*813
HLA Class I Histocompatibility Antigen, B-5 Alpha Chain3     MHC Class I Antigen B*823

External Ids:    HGNC: 49321   Entrez Gene: 31062   Ensembl: ENSG000002347457   OMIM: 1428305   UniProtKB: P018893   
UniProtKB: P304603   UniProtKB: P304613   UniProtKB: P304623   UniProtKB: P304643   UniProtKB: P304663   
UniProtKB: P039893   UniProtKB: P306853   UniProtKB: P184633   UniProtKB: Q953653   UniProtKB: P304753   
UniProtKB: Q048263   UniProtKB: P304793   UniProtKB: P304803   UniProtKB: P304813   UniProtKB: P304833   
UniProtKB: P304843   UniProtKB: P304853   UniProtKB: P304863   UniProtKB: P304873   UniProtKB: P304883   
UniProtKB: P184643   UniProtKB: P304903   UniProtKB: P304913   UniProtKB: P304923   UniProtKB: P304933   
UniProtKB: P304953   UniProtKB: P184653   UniProtKB: P103193   UniProtKB: Q299403   UniProtKB: Q298363   
UniProtKB: Q316123   UniProtKB: P304983   UniProtKB: Q316103   UniProtKB: Q297183   

Export aliases for HLA-B gene to outside databases

Previous GC identifers: GC06M031376 GC06M031426 GC06M031342 GC06M031429 GC06M031345 GC06M031112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-B Gene:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a
heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I
molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum
lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8
exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the
peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the
cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of
each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney
transplantation. Hundreds of HLA-B alleles have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-B Gene:
HLA-B (major histocompatibility complex, class I, B) is a protein-coding gene. Diseases associated with HLA-B include takayasu's arteritis, and drug-induced liver injury due to flucloxacillin. GO annotations related to this gene include peptide antigen binding and receptor binding. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889 (see all)
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  NT_113891.3  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-B gene promoter:
         USF1   ISGF-3   Pax-5   AML1a   p300   AP-2gamma   POU2F1   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-B promoter sequence
   Search Chromatin IP Primers for HLA-B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HLA-B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031321:  view genomic region     (about GC identifiers)

Start:
31,321,649 bp from pter      End:
31,324,989 bp from pter
Size:
3,341 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_167248 2,615,165-2,618,505      Chr6-,NT_167249 2,655,408-2,658,748      Chr6-,NT_167247 2,701,429-2,704,782     
Chr6-,NT_167246 2,668,104-2,671,444      Chr6-,NT_113891.2 2,834,338-2,837,677     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, B-7 alpha chain precursor  
Size: 362 amino acids; 40460 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I
1 PDB 3D structure from and Proteopedia for HLA-B:
3VCL (3D)    
Secondary accessions: Q29638 Q29681 Q29854 Q29861 Q31613 Q5SRJ2 Q9GIX1 Q9TP95

UniProtKB/Swiss-Prot: 1B08_HUMAN, P30460 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-8 alpha chain precursor  
Size: 362 amino acids; 40331 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Selected PDB 3D structures from and Proteopedia for HLA-B (see all 12):
1AGB (3D)        1AGC (3D)        1AGD (3D)        1AGE (3D)        1AGF (3D)        1M05 (3D)    
Secondary accessions: O62901 O95730 O98140 P79542 Q95369 Q95J00 Q9GJ20 Q9MY78 Q9MYF4 Q9TQH6
Q9TQM2 Q9UQT0

UniProtKB/Swiss-Prot: 1B13_HUMAN, P30461 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-13 alpha chain precursor  
Size: 362 amino acids; 40474 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02956 O78180 Q29661 Q29933 Q9GIY5

UniProtKB/Swiss-Prot: 1B14_HUMAN, P30462 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-14 alpha chain precursor  
Size: 362 amino acids; 40358 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02862 P30463

UniProtKB/Swiss-Prot: 1B15_HUMAN, P30464 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-15 alpha chain precursor  
Size: 362 amino acids; 40388 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
3 PDB 3D structures from and Proteopedia for HLA-B:
1XR8 (3D)        1XR9 (3D)        3C9N (3D)    
Secondary accessions: B0V0B8 P30465 P30513 Q29633 Q29636 Q29829 Q29953 Q29982 Q95343 Q95344
Q9BD06

UniProtKB/Swiss-Prot: 1B18_HUMAN, P30466 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-18 alpha chain precursor  
Size: 362 amino acids; 40275 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
1 PDB 3D structure from and Proteopedia for HLA-B:
4JQV (3D)    
Secondary accessions: O62897 Q29845 Q5JP37 Q9BCM6 Q9GJ23 Q9MY84 Q9MYC7 Q9TP37 Q9TQH7

UniProtKB/Swiss-Prot: 1B27_HUMAN, P03989 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-27 alpha chain precursor  
Size: 362 amino acids; 40428 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Selected PDB 3D structures from and Proteopedia for HLA-B (see all 33):
1HSA (3D)        1JGD (3D)        1JGE (3D)        1K5N (3D)        1OF2 (3D)        1OGT (3D)    
Secondary accessions: O19692 P10317 P10318 P19373 P30467 Q08136 Q29693 Q29846 Q29961

UniProtKB/Swiss-Prot: 1B35_HUMAN, P30685 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-35 alpha chain precursor  
Size: 362 amino acids; 40455 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Selected PDB 3D structures from and Proteopedia for HLA-B (see all 35):
1A1N (3D)        1A9B (3D)        1A9E (3D)        1CG9 (3D)        1XH3 (3D)        1ZHK (3D)    
Secondary accessions: O62919 P30468 P30469 P30470 P30471 P30472 P30473 P30474 Q9GJM7 Q9TPV2
Q9TQH3 Q9TQH9 Q9TQN4 Q9TQN6

UniProtKB/Swiss-Prot: 1B37_HUMAN, P18463 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-37 alpha chain precursor  
Size: 362 amino acids; 40456 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19627 Q546L8 Q95HA3 Q95HA8 Q95HM9 Q9GJ31

UniProtKB/Swiss-Prot: 1B38_HUMAN, Q95365 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-38 alpha chain precursor  
Size: 362 amino acids; 40416 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19779 O77959 O78160 Q29935 Q29936 Q95IB8 Q95IH5 Q9BCM8 Q9MY92 Q9MYG1
Q9TPT2

UniProtKB/Swiss-Prot: 1B39_HUMAN, P30475 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-39 alpha chain precursor  
Size: 362 amino acids; 40328 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02960 O78217 P30476 P79504 Q29665 Q29697 Q29749 Q29847 Q29852 Q29858
Q8HWF0 Q9TPQ7

UniProtKB/Swiss-Prot: 1B40_HUMAN, Q04826 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-40 alpha chain precursor  
Size: 362 amino acids; 40505 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19556 O19651 P01890 P30477 P30478 Q29762 Q29842 Q29855 Q30173 Q31603
Q9TPT6

UniProtKB/Swiss-Prot: 1B41_HUMAN, P30479 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-41 alpha chain precursor  
Size: 362 amino acids; 40539 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
2 PDB 3D structures from and Proteopedia for HLA-B:
3LN4 (3D)        3LN5 (3D)    
Secondary accessions: O19595 Q29848 Q5TK77 Q9MY79 Q9MY94

UniProtKB/Swiss-Prot: 1B42_HUMAN, P30480 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-42 alpha chain precursor  
Size: 362 amino acids; 40333 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: P79555

UniProtKB/Swiss-Prot: 1B44_HUMAN, P30481 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-44 alpha chain precursor  
Size: 362 amino acids; 40481 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Selected PDB 3D structures from and Proteopedia for HLA-B (see all 22):
1M6O (3D)        1N2R (3D)        1SYS (3D)        1SYV (3D)        3DX6 (3D)        3DX7 (3D)    
Secondary accessions: P10320 P30482 P79524 Q29850 Q5RIP1 Q860I4 Q861B5 Q9BCM7 Q9MYC3 Q9UQS8

UniProtKB/Swiss-Prot: 1B45_HUMAN, P30483 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-45 alpha chain precursor  
Size: 362 amino acids; 40414 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q9GIZ0 Q9MX21

UniProtKB/Swiss-Prot: 1B46_HUMAN, P30484 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-46 alpha chain precursor  
Size: 362 amino acids; 40440 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q9TPR2

UniProtKB/Swiss-Prot: 1B47_HUMAN, P30485 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-47 alpha chain precursor  
Size: 362 amino acids; 40571 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19555 O77933 Q95392 Q9GIL3

UniProtKB/Swiss-Prot: 1B48_HUMAN, P30486 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-48 alpha chain precursor  
Size: 362 amino acids; 40362 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q29764

UniProtKB/Swiss-Prot: 1B49_HUMAN, P30487 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-49 alpha chain precursor  
Size: 362 amino acids; 40581 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19625 Q9MY37 Q9MY93

UniProtKB/Swiss-Prot: 1B50_HUMAN, P30488 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-50 alpha chain precursor  
Size: 362 amino acids; 40541 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19615 O19624 O19641 O19783 O46702 O78172 Q9TQG1

UniProtKB/Swiss-Prot: 1B51_HUMAN, P18464 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-51 alpha chain precursor  
Size: 362 amino acids; 40566 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Miscellaneous: There is evidence that HLA-B51 is associated with susceptibility to Behcet disease. However, it is
not certain whether HLA-B51 itself or a closely linked gene is responsible for susceptibility. The world
distribution of HLA-B51 in healthy people corresponds to the global distribution of Behcet disease; in Southern
hemisphere countries (Africa, South Pacific, etc.) and in some parts of Europe, the prevalence of HLA-B51 in
healthy people is low or null, corresponding to a low prevalence of Behcet disease. The wide variation that
exists in the relative risk of HLA-B51 would support other nongenetic risk factors
2 PDB 3D structures from and Proteopedia for HLA-B:
1E27 (3D)        1E28 (3D)    
Secondary accessions: O19675 O78173 P30489 Q29851 Q29857 Q96IT9 Q9MY43

UniProtKB/Swiss-Prot: 1B52_HUMAN, P30490 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-52 alpha chain precursor  
Size: 362 amino acids; 40521 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
1 PDB 3D structure from and Proteopedia for HLA-B:
3W39 (3D)    
Secondary accessions: Q9MY75 Q9TPT4

UniProtKB/Swiss-Prot: 1B53_HUMAN, P30491 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-53 alpha chain precursor  
Size: 362 amino acids; 40495 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
2 PDB 3D structures from and Proteopedia for HLA-B:
1A1M (3D)        1A1O (3D)    
Secondary accessions: O78053 O78138 Q30198 Q5TK76 Q9BD43 Q9GJF0 Q9MY42 Q9TP36 Q9TQH8

UniProtKB/Swiss-Prot: 1B54_HUMAN, P30492 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-54 alpha chain precursor  
Size: 362 amino acids; 40380 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q9TPQ9

UniProtKB/Swiss-Prot: 1B55_HUMAN, P30493 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-55 alpha chain precursor  
Size: 362 amino acids; 40496 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O78163 P30494 P79489 P79523 Q8MGQ3 Q9GIZ9 Q9GJ00

UniProtKB/Swiss-Prot: 1B56_HUMAN, P30495 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-56 alpha chain precursor  
Size: 362 amino acids; 40478 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19758 P30496 P79490 Q9GIM3 Q9GJ17 Q9TPR4

UniProtKB/Swiss-Prot: 1B57_HUMAN, P18465 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-57 alpha chain precursor  
Size: 362 amino acids; 40224 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Selected PDB 3D structures from and Proteopedia for HLA-B (see all 11):
2BVO (3D)        2BVP (3D)        2BVQ (3D)        2HJL (3D)        2RFX (3D)        2YPK (3D)    
Secondary accessions: O62917 P30497 P79496 Q29679 Q5QT24

UniProtKB/Swiss-Prot: 1B58_HUMAN, P10319 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-58 alpha chain precursor  
Size: 362 amino acids; 40337 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q29925 Q9TP35 Q9TPS6

UniProtKB/Swiss-Prot: 1B59_HUMAN, Q29940 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-59 alpha chain precursor  
Size: 362 amino acids; 40584 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02957

UniProtKB/Swiss-Prot: 1B67_HUMAN, Q29836 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-67 alpha chain precursor  
Size: 362 amino acids; 40342 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q29678 Q8SNC5 Q95IA6 Q9BD38

UniProtKB/Swiss-Prot: 1B73_HUMAN, Q31612 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-73 alpha chain precursor  
Size: 363 amino acids; 40435 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: G3GN01

UniProtKB/Swiss-Prot: 1B78_HUMAN, P30498 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-78 alpha chain precursor  
Size: 362 amino acids; 40478 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O62915 Q29924 Q546M4

UniProtKB/Swiss-Prot: 1B81_HUMAN, Q31610 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-81 alpha chain precursor  
Size: 362 amino acids; 40400 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)

UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, B-82 alpha chain precursor  
Size: 362 amino acids; 40421 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q29695 Q29742 Q8MHN4 Q9MY61 Q9MYB8

Explore the universe of human proteins at neXtProt for HLA-B: NX_Q29718

Explore proteomics data for HLA-B at MOPED

Post-translational modifications: 

  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the
    protein for rapid degradation via the ubiquitin system (By similarity)1
  • Ubiquitination2 at Lys92, Lys267, Lys292
  • Glycosylation2 at Asn110
  • Modification sites at PhosphoSitePlus

  • See HLA-B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005505.2  
    ENSEMBL proteins: 
     ENSP00000399168   ENSP00000405931  
    Reactome Protein details: P30492 P30483 P30495 Q31610 P30491 P18465 P18464 Q29718 Q29836 P30464 P30480 Q31612 P30490 P30498 P30460 P30484 P30487 P18463 P30462 P30685 P30488 P01889 P30493 P10319 P03989 Q29940 P30466 P30475 Q95365 P30461 Q04826 P30485 P30481 P30479

    HLA-B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HLA-B
    OriGene Protein Over-expression Lysate for HLA-B
    OriGene MassSpec for HLA-B
    OriGene Custom Protein Services for HLA-B
    GenScript Custom Purified and Recombinant Proteins Services for HLA-B
    Novus Biologicals HLA-B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    HLA-B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-B
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HLA-B
    OriGene Custom Antibody Services for HLA-B
    Novus Biologicals HLA-B Antibodies
    Abcam antibodies for HLA-B (P30499, P30492, P03989, P30460, P30450, P30462, Q546L8, P30486, P01889, P30481, P04222)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HLA-B
    LSBio Antibodies in human, mouse, rat for HLA-B

    HLA-B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01889
    Graphical View of Domain Structure for InterPro Entry P30460
    Graphical View of Domain Structure for InterPro Entry P30461
    Graphical View of Domain Structure for InterPro Entry P30462
    Graphical View of Domain Structure for InterPro Entry P30464
    Graphical View of Domain Structure for InterPro Entry P30466
    Graphical View of Domain Structure for InterPro Entry P03989
    Graphical View of Domain Structure for InterPro Entry P30685
    Graphical View of Domain Structure for InterPro Entry P18463
    Graphical View of Domain Structure for InterPro Entry Q95365
    Graphical View of Domain Structure for InterPro Entry P30475
    Graphical View of Domain Structure for InterPro Entry Q04826
    Graphical View of Domain Structure for InterPro Entry P30479
    Graphical View of Domain Structure for InterPro Entry P30480
    Graphical View of Domain Structure for InterPro Entry P30481
    Graphical View of Domain Structure for InterPro Entry P30483
    Graphical View of Domain Structure for InterPro Entry P30484
    Graphical View of Domain Structure for InterPro Entry P30485
    Graphical View of Domain Structure for InterPro Entry P30486
    Graphical View of Domain Structure for InterPro Entry P30487
    Graphical View of Domain Structure for InterPro Entry P30488
    Graphical View of Domain Structure for InterPro Entry P18464
    Graphical View of Domain Structure for InterPro Entry P30490
    Graphical View of Domain Structure for InterPro Entry P30491
    Graphical View of Domain Structure for InterPro Entry P30492
    Graphical View of Domain Structure for InterPro Entry P30493
    Graphical View of Domain Structure for InterPro Entry P30495
    Graphical View of Domain Structure for InterPro Entry P18465
    Graphical View of Domain Structure for InterPro Entry P10319
    Graphical View of Domain Structure for InterPro Entry Q29940
    Graphical View of Domain Structure for InterPro Entry Q29836
    Graphical View of Domain Structure for InterPro Entry Q31612
    Graphical View of Domain Structure for InterPro Entry P30498
    Graphical View of Domain Structure for InterPro Entry Q31610
    Graphical View of Domain Structure for InterPro Entry Q29718

    ProtoNet protein and cluster: P01889

    3 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1B07_HUMAN, P01889
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B08_HUMAN, P30460
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B13_HUMAN, P30461
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B14_HUMAN, P30462
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B15_HUMAN, P30464
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B18_HUMAN, P30466
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B27_HUMAN, P03989
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B35_HUMAN, P30685
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B37_HUMAN, P18463
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B38_HUMAN, Q95365
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B39_HUMAN, P30475
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B40_HUMAN, Q04826
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B41_HUMAN, P30479
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B42_HUMAN, P30480
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B44_HUMAN, P30481
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B45_HUMAN, P30483
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B46_HUMAN, P30484
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B47_HUMAN, P30485
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B48_HUMAN, P30486
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B49_HUMAN, P30487
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B50_HUMAN, P30488
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B51_HUMAN, P18464
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B52_HUMAN, P30490
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B53_HUMAN, P30491
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B54_HUMAN, P30492
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B55_HUMAN, P30493
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B56_HUMAN, P30495
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B57_HUMAN, P18465
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B58_HUMAN, P10319
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B59_HUMAN, Q29940
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B67_HUMAN, Q29836
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B73_HUMAN, Q31612
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B78_HUMAN, P30498
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B81_HUMAN, Q31610
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 1B07_HUMAN, P01889 (see all)
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-B:
    HLA-B,beta chain,44kDa,class Ia (see MHC1)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0005515protein binding ----
    GO:0042605peptide antigen binding ISS--
    GO:0046977NOT TAP binding IDA8617941
         
    HLA-B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for H2-D1):
     behavior/neurological  hematopoietic system  immune system  mortality/aging  nervous system 
     no phenotypic analysis 

    HLA-B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out H2-D1H2-tm1Bpe for HLA-B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-B

    miRNA
    Products:
        
    miRTarBase miRNAs that target HLA-B:
    hsa-mir-615-3p (MIRT039965)

    Block miRNA regulation of human, mouse, rat HLA-B using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HLA-B:
    hsa-miR-1299 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidHLA-B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-B
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-B

    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-B (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-B (NM_005514)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLA-B
    Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    1B07_HUMAN, P01889: Membrane; Single-pass type I membrane protein
    1B08_HUMAN, P30460: Membrane; Single-pass type I membrane protein
    1B13_HUMAN, P30461: Membrane; Single-pass type I membrane protein
    1B14_HUMAN, P30462: Membrane; Single-pass type I membrane protein
    1B15_HUMAN, P30464: Membrane; Single-pass type I membrane protein
    1B18_HUMAN, P30466: Membrane; Single-pass type I membrane protein
    1B27_HUMAN, P03989: Membrane; Single-pass type I membrane protein
    1B35_HUMAN, P30685: Membrane; Single-pass type I membrane protein
    1B37_HUMAN, P18463: Membrane; Single-pass type I membrane protein
    1B38_HUMAN, Q95365: Membrane; Single-pass type I membrane protein
    1B39_HUMAN, P30475: Membrane; Single-pass type I membrane protein
    1B40_HUMAN, Q04826: Membrane; Single-pass type I membrane protein
    1B41_HUMAN, P30479: Membrane; Single-pass type I membrane protein
    1B42_HUMAN, P30480: Membrane; Single-pass type I membrane protein
    1B44_HUMAN, P30481: Membrane; Single-pass type I membrane protein
    1B45_HUMAN, P30483: Membrane; Single-pass type I membrane protein
    1B46_HUMAN, P30484: Membrane; Single-pass type I membrane protein
    1B47_HUMAN, P30485: Membrane; Single-pass type I membrane protein
    1B48_HUMAN, P30486: Membrane; Single-pass type I membrane protein
    1B49_HUMAN, P30487: Membrane; Single-pass type I membrane protein
    1B50_HUMAN, P30488: Membrane; Single-pass type I membrane protein
    1B51_HUMAN, P18464: Membrane; Single-pass type I membrane protein
    1B52_HUMAN, P30490: Membrane; Single-pass type I membrane protein
    1B53_HUMAN, P30491: Membrane; Single-pass type I membrane protein
    1B54_HUMAN, P30492: Membrane; Single-pass type I membrane protein
    1B55_HUMAN, P30493: Membrane; Single-pass type I membrane protein
    1B56_HUMAN, P30495: Membrane; Single-pass type I membrane protein
    1B57_HUMAN, P18465: Membrane; Single-pass type I membrane protein
    1B58_HUMAN, P10319: Membrane; Single-pass type I membrane protein
    1B59_HUMAN, Q29940: Membrane; Single-pass type I membrane protein
    1B67_HUMAN, Q29836: Membrane; Single-pass type I membrane protein
    1B73_HUMAN, Q31612: Membrane; Single-pass type I membrane protein
    1B78_HUMAN, P30498: Membrane; Single-pass type I membrane protein
    1B81_HUMAN, Q31610: Membrane; Single-pass type I membrane protein
    1B82_HUMAN, Q29718: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    cytosol3
    cytoskeleton2
    extracellular2
    lysosome2
    nucleus2
    vacuole2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS518865
    GO:0009986cell surface ISS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--

    HLA-B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for HLA-B About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Proteasome Degradation0.57
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    Immune response Antigen presentation by MHC class I0.68
    3Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-B
        CDC42 Pathway
    CTL Mediated Apoptosis

    2 GeneGo (Thomson Reuters) Pathways for HLA-B
        Immune response Antigen presentation by MHC class I
    Immune response Role of DAP12 receptors in NK cells

    3 BioSystems Pathways for HLA-B
        Type II interferon signaling (IFNG)
    Allograft Rejection
    Proteasome Degradation

    Selected Reactome Pathways for HLA-B (see all 7)
        Endosomal/Vacuolar pathway
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    DAP12 interactions

    1 PharmGKB Pathway for HLA-B
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for HLA-B) (see all 14):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    HLA-B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HLA-B: 
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HLA-B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HLA-B (P039892 P304602 P304912 P304612 P184642 P306852 P018892 Q316122, 3 P304812, 3 ENSP000003991684) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617692, ENSP000003408584MINT-25080 STRING: ENSP00000340858
    ATF7IPQ6VMQ62MINT-61906
    VIPR1P322412MINT-8144492
    CD8AENSP000002836354STRING: ENSP00000283635
    CSF1ENSP000003275134STRING: ENSP00000327513
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0002486antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IDA--

    HLA-B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-B (1B82)

    1 HMDB Compound for HLA-B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glycerylphosphorylethanolamine2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)1190-00-7--

    1 DrugBank Compound for HLA-B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Formylmethionine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HLA-B gene (see all 73)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    listeriolysin 38.8 1 7589099 (1)
    solium 30.8 3 8295903 (1), 17210192 (1)
    2',5'-oligoadenylate 29.6 1 10074208 (1)
    castanospermine 16.9 1 8440676 (1)
    polyinosinic-polycytidylic acid 15.4 1 17063122 (1)
    glycolipid 14.1 1 15857311 (1)
    3beta-hydroxysteroid 11.4 2 19036885 (1), 8288710 (1)
    phycoerythrin 10.4 2 1764978 (1)
    udpglucose 10.1 2 18202596 (1), 12198488 (1)
    chlorzoxazone 8.03 1 9186495 (1)

    5 PharmGKB related drug/compound annotations for HLA-B gene    About this table
    Drug/compound PharmGKB Annotation
    abacavir  CA  
    allopurinol  CA  
    carbamazepine  CA  
    phenytoin  CA  
    ribavirin



    HLA-B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for HLA-B gene: 
    NM_005514.6  

    Unigene Clusters for HLA-B:

    Major histocompatibility complex, class I, B
    Hs.77961  [show with all ESTs], Hs.654404  [show with all ESTs]
    Unigene Representative Sequences: AK124160, BF526307
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481849 ENST00000497377 ENST00000412585(uc003ntg.1 uc003nth.2 uc003nti.1)
    ENST00000463574 ENST00000498007 ENST00000434333(uc003ntf.2) ENST00000474381(uc010jso.2)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HLA-B using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HLA-B:
    hsa-miR-1299 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidHLA-B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HLA-B
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    OriGene clones in human, mouse for HLA-B (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-B (NM_005514)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-B
    Primer
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    OriGene qPCR primer pairs and template standards for HLA-B
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-B
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-B
      QuantiFast Probe-based Assays in human, mouse, rat HLA-B

    Additional mRNA sequence: 

    J00192.1 M64254.1 M64258.1 X07061.1 

    Selected DOTS entries (see all 224):

    DT.100654997  DT.91783947  DT.91783902  DT.100046073  DT.91883296  DT.91798390  DT.100850152  DT.97870097 
    DT.91867091  DT.91985759  DT.91645158  DT.91921040  DT.95332054  DT.95331727  DT.453586  DT.100046076 
    DT.100867489  DT.100850220  DT.87002539  DT.95331865  DT.97870116  DT.121310237  DT.95331852  DT.98083417 

    Selected AceView cDNA sequences (see all 792):

    L47338 CR621734 AF436098 BM917649 T98139 Y13567 M32317 AW973441 
    BM917823 BQ053032 BM917124 X91749 U29057 NM_005514 CN480959 M64259 
    BF757472 M64255 CD620614 L33922 AA352651 BF760073 BX090262 BE166228 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HLA-B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HLA-B Expression
    About this image


    HLA-B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Thalamus
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical tissue-derived cells (CNTO2476)
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Adipose-derived mesenchymal stem cells (family)
    HLA-B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-B Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.77961 Hs.654404
        Pathway & Disease-focused RT2 Profiler PCR Array including HLA-B: 
              Type I Interferon Response in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for HLA-B
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-B
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-B
    QuantiFast Probe-based Assays in human, mouse, rat HLA-B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-B gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-D15 histocompatibility 2, D region locus 1   --   17 (18.61 cM) 35262730 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1002173221 uncharacterized LOC100217322 52.61(n)
    42.16(a)
      100217322  XM_004919390.1  XP_004919447.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7964191 major histocompatibility complex class I-related gene more 44.14(n)
    34.36(a)
      796419  XM_001336713.5  XP_001336749.4 


    ENSEMBL Gene Tree for HLA-B (if available)
    TreeFam Gene Tree for HLA-B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for HLA-B gene
    HLA-F2  MR12  FCGRT2  HFE2  HLA-E2  HLA-C2  HLA-A2  HLA-G2  
    AZGP12  
    Selected SIMAP similar genes for HLA-B using alignment to 6308 protein entries:     1B07_HUMAN (see all proteins) (see all similar genes):
    HLA-A*0201V3    HLA-Cw3    HLA-Cw2    B-1510    HLA-B*3512    B-3501
    B*15    B*35    HLA-ABC    HLA-Bw62.1    HLA-B*35JAC    HLA-B27
    HLA-B*15UL    HLA-B1501V2    HLA-Bw62.4    HLA-B*3531    HLA-B*0707    HLA-B*1522

    HLA-B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    1B07_HUMAN, P01889: The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06
    (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02
    1B08_HUMAN, P30460: The following alleles of B-8 are known: B*08:01, B*08:04, B*08:06, B*08:07 (B*NV), B*08:09 (B*HM;
    B*08HO), B*08:10, B*08:12, B*08:13 and B*08:14. The sequence shown is B*08:01
    1B13_HUMAN, P30461: The following alleles of B-13 are known: B*13:01 (B13.1), B*13:02 (B13.2), B*13:04 and B*13:08. The
    sequence shown is that of B*13:02
    1B14_HUMAN, P30462: The following alleles of B-14 are known: B*14:01 (Bw-64; B-64), B*14:02 (Bw-65, B-65) and B*14:03.
    The sequence shown is that of B*14:01
    1B15_HUMAN, P30464: The following alleles of B-15 are known: B*15:01 (Bw-62; B-62), B*15:02 (Bw-75, B-75), B*15:03
    (Bw-72; B-72; B-70) B*15:04, B*15:11, B*15:19 and B*15:66. The sequence shown is that of B*15:01
    1B18_HUMAN, P30466: The following alleles of B-18 are known: B*18:01 B*18:02, B*18:03, B*18:07 (B*MF), B*18:10, B*18:11,
    B*18:12 and B*18:13. The sequence shown is that of B*18:01
    1B27_HUMAN, P03989: The following alleles of B-27 are known: B*27:01=B*27:05, B*27:02 (B27.2; B-27k; B27e), B*27:03
    (B27d), B*27:04, B*27:06, B*27:07, B*27:08 (B7Qui) and B*27:09 (B27-ci). The sequence shown is that of B*27:01
    1B35_HUMAN, P30685: The following alleles of B-35 are known: B*35:01, B*35:02, B*35:03, B*35:04, B*35:05 (B35-G),
    B*35:06 (B35-K), B*35:07, B*35:08, B*35:25, B*35:28, B*35:29 (B*KG), B*35:30, B*35:32 (B*TMUL) and B*35:36. The
    sequence shown is that of B*35:01
    1B37_HUMAN, P18463: The following alleles of B-37 are known: B*37:01, B*37:04 and B*37:05. The sequence shown is that of
    B*37:01
    1B38_HUMAN, Q95365: The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06,
    B*38:07 and B*38:08. The sequence shown is that of B*38:01
    1B39_HUMAN, P30475: The following alleles of B-39 are known: B*39:01 (B39.1), B*39:02 (B9.2), B*39:03, B*39:04 (B39N),
    B*39:05 (ST-16), B*39:06 (B39G), B*39:07 (B39uw3), B*39:09, B*39:10, B*39:12 (B3901v), B*39:23 (B39022v1) and
    B*39:24. The sequence shown is that of B*39:01
    1B40_HUMAN, Q04826: The following alleles of B-40 are known: B*40:01, B*40:02, B*40:03 (B40-G1), B*40:04 (B40-G2),
    B*40:05 (BN21), B*40:06, B*40:08, B*40:09, B*40:16 and B*40:27. The sequence shown is that of B*40:02
    1B41_HUMAN, P30479: The following alleles of B-41 are known: B*41:01, B*41:02 (B41.2), B*41:03, B*41:04 and B*41:05. The
    sequence shown is that of B*41:01
    1B42_HUMAN, P30480: The following alleles of B-42 are known: B*42:01 (Bw-42) and B*42:02. The sequence shown is that of
    B*42:01
    1B44_HUMAN, P30481: The following alleles of B-44 are known: B*44:02 (B-12; B44.2), B*44:04, B*44:05, B*44:07, B*44:08
    (B44BO), B*44:09, B*44:12 and B*44:13. The sequence shown is that of B*44:02
    1B45_HUMAN, P30483: The following alleles of B-45 are known: B*45:01 (B-12), B*45:03 and B*45:04. The sequence shown is
    that of B*45:01
    1B46_HUMAN, P30484: The following alleles of B-46 are known: B*46:01 and B*46:02. The sequence shown is that of B*46:01
    1B47_HUMAN, P30485: The following alleles of B-47 are known: B*47:01, B*47:02 and B*47:03. The sequence shown is that of
    B*47:01
    1B48_HUMAN, P30486: The following alleles of B-48 are known: B*48:01 and B*48:03. The sequence shown is that of B*48:01
    1B49_HUMAN, P30487: The following alleles of B-49 are known: B*49:01, B*49:02 and B*49:03 (B*RA). The sequence shown is
    that of B*49:01
    1B50_HUMAN, P30488: The following alleles of B-50 are known: B*50:01, B*50:02 (B*45ZJ; B50IM) and B*50:04. The sequence
    shown is that of B*50:01
    1B51_HUMAN, P18464: The following alleles of B-51 are known: B*51:01, B*51:03, B*51:04, B*51:08 and B*51:24. The
    sequence shown is that of B*51:01
    1B52_HUMAN, P30490: The following alleles of B-52 are known: B*52:01, B*52:02 (B*52012V) and B*52:03. The sequence shown
    is that of B*52:01
    1B53_HUMAN, P30491: The following alleles of B-53 are known: B*53:01, B*53:02, B*53:03, B*53:04, B*53:05, B*53:06 and
    B*53:07. The sequence shown is that of B*53:01
    1B54_HUMAN, P30492: The following alleles of B-54 are known: B*54:01 and B*54:02 (B5401V). The sequence shown is that of
    B*54:01
    1B55_HUMAN, P30493: The following alleles of B-55 are known: B*55:01, B*55:02, B*55:04 (B55.2), B*55:05, B*55:08 (B*ER),
    B*55:09 and B*55:12. The sequence shown is that of B*55:01
    1B56_HUMAN, P30495: The following alleles of B-56 are known: B*56:01, B*56:02, B*56:03 (B22N), B*56:04, B*56:05 (B56V1),
    B*56:06 and B*56:07. The sequence shown is that of B*56:01
    1B57_HUMAN, P18465: The following alleles of B-57 are known: B*57:01, B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05.
    The sequence shown is that of B*57:01
    1B58_HUMAN, P10319: The following alleles of B-58 are known: B*58:01, B*58:02, B*58:04 and B*58:05. The sequence shown
    is that of B*58:01. Allele B*58:01 is an important genetic risk factor for severe cutaneous adverse reactions to
    allopurinol in the Han Chinese population [MIM:608579]
    1B67_HUMAN, Q29836: The following alleles of B-67 are known: B*67:01 (B-67LAV) and B*67:02. The sequence shown is that
    of B*67:01
    1B78_HUMAN, P30498: The following alleles of B-78 are known: B*78:01 (B SNA), B*78:02 and B*78:03. The sequence shown is
    that of B*78:01
    1B82_HUMAN, Q29718: The following alleles of B-82 are known: B*82:01 and B*82:02. The sequence shown is that of B*82:01


    Selected SNPs for HLA-B (see all 1647)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10931,2
    C,Fhistocompatibility131321906(+) GTCACA/GGTGGA 1 -- ut316Minor allele frequency- G:0.11NA CSA WA 246
    rs10558901,2
    C,Ahistocompatibility131321915(-) ACCCTT/CGTGTC 1 -- ut314Minor allele frequency- C:0.19NA WA EA 360
    rs10558491,2
    C,Ahistocompatibility131321916(-) CACCCC/G/TTGTGT 2 -- ut315NA MN WA EA 544
    rs10558211,2
    C,Fhistocompatibility131321919(-) GCCCAC/ACTGTG 1 -- ut316Minor allele frequency- A:0.06MN NA CSA WA 427
    rs10496451,2
    Chistocompatibility131321922(-) ACAGCC/TCACCC 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs10553481,2
    Chistocompatibility131321948(-) TTAGCA/CTAATG 1 -- ut315Minor allele frequency- C:0.24NA CSA WA EA 362
    rs10551491,2
    C,F,Ahistocompatibility131321958(-) TGCGTC/TCCTGT 1 -- ut314Minor allele frequency- T:0.17MN WA NA EA 542
    rs715633141,2
    Chistocompatibility131321961(+) GGGACG/ACAGAC 1 -- ut314Minor allele frequency- A:0.04NA EA 244
    rs10541111,2
    C,F,Ahistocompatibility131322026(-) TTCACG/TCCTCC 1 -- ut317Minor allele frequency- T:0.26MN NA WA EA 420
    rs10537261,2
    C,F,Ahistocompatibility131322047(-) GGGACA/C/TGAGAT 1 -- ut319NA MN CSA EA 307

    HapMap Linkage Disequilibrium report for HLA-B (31321649 - 31324989 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-B (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731821CNV Deletion23290073
    dgv1094e199CNV Deletion23128226
    esv2422229CNV Deletion17116639
    dgv1043e201CNV Deletion23290073
    dgv1042e201CNV Deletion23290073
    esv2422407CNV Duplication17116639
    esv2946CNV Duplication18987735
    nsv462814CNV Loss19166990
    dgv103e19CNV Loss19470904
    esv9271CNV Loss19470904

    Human Gene Mutation Database (HGMD): HLA-B
    Locus Specific Mutation Databases (LSDB): HLA-B

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-B
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 142830   
    OMIM disorders: 106300  608579  
    UniProtKB/Swiss-Prot: 1B82_HUMAN, Q29718
  • Stevens-Johnson syndrome (SJS) [MIM:608579]: A rare blistering mucocutaneous disease that share clinical
    and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever,
    malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal
    involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin
    epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include
    ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe
    adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased
    susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02
  • Spondyloarthropathy 1 (SPDA1) [MIM:106300]: A chronic rheumatic disease with multifactorial inheritance.
    It includes a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis,
    reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and
    undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same
    patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the
    form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative
    spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac,
    intervertebral, and costovertebral joints. Note=Disease susceptibility is associated with variations affecting
    the gene represented in this entry. A restricted number of HLA-B27 subtypes can be associated with ankylosing
    spondylitis and other B27-related diseases, and an elevated frequency of the B*2702 allele in ankylosing
    spondylitis patients is identified. The allele B*2707 seems to have a protective role some populations because it
    was found only in the healthy controls

  • Selected diseases for HLA-B (see all 309):    
    About MalaCards
    takayasu's arteritis    drug-induced liver injury due to flucloxacillin    abacavir hypersensitivity    toxic epidermal necrolysis
    pustulosis of palm and sole    synovitis, chronic    stevens-johnson syndrome    spondyloarthropathy
    spondyloarthropathy 1    hypersensitivity syndrome, carbamazepine-induced    behcet's disease    copd, rate of decline of lung function in
    aortitis    spondylitis    ankylosing spondylitis    giant cell myocarditis
    postherpetic neuralgia    nail disease    glioblastoma multiforme    plantar fasciitis

    19 diseases from the University of Copenhagen DISEASES database for HLA-B:
    Melanoma     Vaccinia     Influenza     Hypersensitivity reaction type II disease
    Uveitis     Vasculitis     Acquired immunodeficiency syndrome     Lymphoma
    Diabetes mellitus     Multiple sclerosis     Ankylosing spondylitis     Arthritis
    Myositis     Carcinoma     Malaria     Hemochromatosis
    Leukemia     Stevens-Johnson syndrome     Aphthous stomatitis

    HLA-B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for HLA-B gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydatids 66.1 15 9226695 (2), 11119517 (1), 15198645 (1), 8479805 (1) (see all 13)
    hydatid cyst 63.2 37 17767016 (4), 16562482 (2), 9236937 (2), 8541895 (2) (see all 26)
    immunodeficiency 55.9 52 20219903 (2), 12885919 (2), 12414957 (2), 1316930 (1) (see all 42)
    behcet disease 54.6 25 10205273 (4), 8872174 (3), 1356945 (2), 10513813 (2) (see all 13)
    myopathies idiopathic inflammatory 50.6 2 17616993 (1), 18974565 (1)
    influenza 44.3 41 2378639 (2), 16631409 (2), 16950949 (2), 16303886 (2) (see all 23)
    myositis 40.6 10 16224250 (5), 17360184 (2), 16224247 (1), 18534849 (1)
    tetanus 36.5 4 10886393 (1), 14654644 (1), 8145033 (1), 7973459 (1)
    autoimmune diseases 35.5 7 9606177 (1), 12807817 (1), 19743458 (1), 10432437 (1) (see all 6)
    polymyositis 35.4 2 19730931 (1), 11953983 (1)

    Genetic Association Database (GAD): HLA-B
    Human Genome Epidemiology (HuGE) Navigator: HLA-B (2951 documents)

    Export disorders for HLA-B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for HLA-B gene, integrated from 10 sources (see all 2243):
    (articles sorted by number of sources associating them with HLA-B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [HLA-B gene polymorphism detected by high-resolution sequence-based typing in Guangdong Han populations]. (PubMed id 16456786)1, 4, 9 Li Y....Liao C. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    2. Hla-B genotype in Japanese patients with Crohn's disease. (PubMed id 14530653)1, 4, 9 Kinouchi Y....Shimosegawa T. (Dis. Colon Rectum 2003)
    3. [Association of HLA-A, B antigens with susceptibility to advanced endometriosis in Koreans]. (PubMed id 18458507)1, 4, 9 Whang D.H....Choi Y.M. (Korean J Lab Med 2008)
    4. Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility. (PubMed id 18588574)1, 4, 9 Fernandez-Morera J.L....Lopez-Larrea C. (Tissue Antigens 2008)
    5. Diversity of MICA and linkage disequilibrium with HLA-B in two North American populations. (PubMed id 16698437)1, 4, 9 Gao X....Carrington M. (Hum. Immunol. 2006)
    6. Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population. (PubMed id 15304009)1, 4, 9 Feng M.L....Qian K.C. (Tissue Antigens 2004)
    7. MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans. (PubMed id 19895570)1, 4, 9 Sohn Y.H....Kwon O.J. (Tissue Antigens 2010)
    8. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. (PubMed id 19143813)1, 4, 9 Howson J.M....Todd J.A. (amp 2009)
    9. Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B. (PubMed id 11118029)1, 4, 9 Nejentsev S....Ilonen J. (Diabetes 2000)
    10. Polymorphisms of HLA-A and HLA-B genes in genetic susceptibility to esophageal carcinoma in Chaoshan Han Chinese. (PubMed id 19392852)1, 4, 9 Hu S.P....Cai K.L. (Dis. Esophagus 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3106 HGNC: 4932 AceView: HLA-B Ensembl:ENSG00000234745 euGenes: HUgn3106
    ECgene: HLA-B Kegg: 3106 H-InvDB: HLA-B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HLA-B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HLA-B gene:
    Search GeneIP for patents involving HLA-B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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