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Aliases for HLA-B Gene

Aliases for HLA-B Gene

  • Major Histocompatibility Complex, Class I, B 2 3
  • SPDA1 3 6
  • HLAB 3 4
  • HLA Class I Histocompatibility Antigen, B-12 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-21 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-5 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B Alpha Chain 3
  • MHC Class I Antigen HLA-B Heavy Chain 3
  • MHC HLA-B Transmembrane Glycoprotein 3
  • MHC HLA-B Cell Surface Glycoprotein 3
  • MHC Class I HLA Heavy Chain 3
  • MHC Class I Antigen GN00104 3
  • Leukocyte Antigen Class I-B 3
  • MHC Class I Antigen SHCHA 3
  • MHC Class I Antigen B*13 4
  • MHC Class I Antigen B*14 4
  • MHC Class I Antigen B*15 4
  • MHC Class I Antigen B*18 4
  • MHC Class I Antigen B*27 4
  • MHC Class I Antigen B*35 4
  • MHC Class I Antigen B*37 4
  • MHC Class I Antigen B*38 4
  • MHC Class I Antigen B*39 4
  • MHC Class I Antigen B*40 4
  • MHC Class I Antigen B*41 4
  • MHC Class I Antigen B*42 4
  • MHC Class I Antigen B*44 4
  • MHC Class I Antigen B*45 4
  • MHC Class I Antigen B*46 4
  • MHC Class I Antigen B*47 4
  • MHC Class I Antigen B*48 4
  • MHC Class I Antigen B*49 4
  • MHC Class I Antigen B*50 4
  • MHC Class I Antigen B*51 4
  • MHC Class I Antigen B*52 4
  • MHC Class I Antigen B*53 4
  • MHC Class I Antigen B*54 4
  • MHC Class I Antigen B*55 4
  • MHC Class I Antigen B*56 4
  • MHC Class I Antigen B*57 4
  • MHC Class I Antigen B*58 4
  • MHC Class I Antigen B*59 4
  • MHC Class I Antigen B*67 4
  • MHC Class I Antigen B*73 4
  • MHC Class I Antigen B*78 4
  • MHC Class I Antigen B*81 4
  • MHC Class I Antigen B*82 4
  • MHC Class I Antigen B*7 4
  • MHC Class I Antigen B*8 4
  • Ankylosing Spondylitis 2
  • Lymphocyte Antigen 3
  • Bw-22 4
  • Bw-41 4
  • Bw-44 4
  • Bw-45 4
  • Bw-46 4
  • Bw-47 4
  • Bw-48 4
  • Bw-50 4
  • Bw-52 4
  • Bw-53 4
  • Bw-54 4
  • Bw-55 4
  • Bw-56 4
  • Bw-57 4
  • Bw-58 4
  • Bw-60 4
  • Bw-4 4
  • BDT 4
  • AS 3

External Ids for HLA-B Gene

Previous HGNC Symbols for HLA-B Gene

  • AS

Previous GeneCards Identifiers for HLA-B Gene

  • GC06M031376
  • GC06M031426
  • GC06M031342
  • GC06M031429
  • GC06M031345
  • GC06M031321
  • GC06M031112

Summaries for HLA-B Gene

Entrez Gene Summary for HLA-B Gene

  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-B Gene

HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include spondyloarthropathy 1 and takayasu's arteritis. Among its related pathways are Signaling by FGFR and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include receptor binding and peptide antigen binding. An important paralog of this gene is MR1.

Gene Wiki entry for HLA-B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-B Gene

Genomics for HLA-B Gene

Regulatory Elements for HLA-B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HLA-B Gene

Start:
31,353,872 bp from pter
End:
31,357,212 bp from pter
Size:
3,341 bases
Orientation:
Minus strand

Genomic View for HLA-B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-B Gene

  • Protein details for HLA-B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01889-1B07_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, B-7 alpha chain
    Protein Accession:
    P01889
    Secondary Accessions:
    • Q29638
    • Q29681
    • Q29854
    • Q29861
    • Q31613
    • Q5SRJ2
    • Q9GIX1
    • Q9TP95

    Protein attributes for HLA-B Gene

    Size:
    362 amino acids
    Molecular mass:
    40460 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I.

    Three dimensional structures from OCA and Proteopedia for HLA-B Gene

neXtProt entry for HLA-B Gene

Proteomics data for HLA-B Gene at MOPED

Post-translational modifications for HLA-B Gene

No data available for DME Specific Peptides for HLA-B Gene

Domains for HLA-B Gene

Gene Families for HLA-B Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • HLA :Histocompatibility complex

Graphical View of Domain Structure for InterPro Entry

P01889

UniProtKB/Swiss-Prot:

1B38_HUMAN :
  • P01889
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-B: view

Function for HLA-B Gene

Gene Ontology (GO) - Molecular Function for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20008523
GO:0005515 protein binding --
GO:0042605 peptide antigen binding ISS --
GO:0046977 NOT TAP binding IDA 8617941
GO:0051087 chaperone binding IPI 15056662
genes like me logo Genes that share ontologies with HLA-B: view
genes like me logo Genes that share phenotypes with HLA-B: view

Animal Models for HLA-B Gene

MGI Knock Outs for HLA-B:

Animal Model Products

CRISPR Products

miRNA for HLA-B Gene

miRTarBase miRNAs that target HLA-B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HLA-B Gene

Localization for HLA-B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-B Gene COMPARTMENTS Subcellular localization image for HLA-B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
cytosol 3
cytoskeleton 2
extracellular 2
lysosome 2
nucleus 2
vacuole 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 518865
genes like me logo Genes that share ontologies with HLA-B: view

Pathways for HLA-B Gene

genes like me logo Genes that share pathways with HLA-B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS --
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IDA 22031944
genes like me logo Genes that share ontologies with HLA-B: view

Compounds for HLA-B Gene

(1) HMDB Compounds for HLA-B Gene

Compound Synonyms Cas Number PubMed IDs
Glycerylphosphorylethanolamine
  • 2-aminoethyl ester 1-Glycerophosphoric acid
1190-00-7

(1) Drugbank Compounds for HLA-B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-Formylmethionine
target

(73) Novoseek inferred chemical compound relationships for HLA-B Gene

Compound -log(P) Hits PubMed IDs
listeriolysin 38.8 1
solium 30.8 2
2,5-oligoadenylate 29.6 1
castanospermine 16.9 1
polyinosinic-polycytidylic acid 15.4 1

(8) PharmGKB related drug/compound annotations for HLA-B Gene

genes like me logo Genes that share compounds with HLA-B: view

Transcripts for HLA-B Gene

Unigene Clusters for HLA-B Gene

Major histocompatibility complex, class I, B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLA-B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-B Gene

No ASD Table

Relevant External Links for HLA-B Gene

GeneLoc Exon Structure for
HLA-B
ECgene alternative splicing isoforms for
HLA-B

Expression for HLA-B Gene

mRNA expression in normal human tissues for HLA-B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-B Gene

This gene is overexpressed in Whole Blood (15.6).

Protein differential expression in normal tissues for HLA-B Gene

This gene is overexpressed in Amniocyte (36.4) and Oral epithelium (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-B Gene

SOURCE GeneReport for Unigene cluster for HLA-B Gene Hs.77961

genes like me logo Genes that share expressions with HLA-B: view

Expression partners for HLA-B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HLA-B Gene

Orthologs for HLA-B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BOLA-A 35
  • 82.96 (n)
  • 76.12 (a)
dog
(Canis familiaris)
Mammalia DLA88 35
  • 82.59 (n)
  • 76.26 (a)
chimpanzee
(Pan troglodytes)
Mammalia PATR-B 35
  • 96.13 (n)
  • 93.09 (a)
PATR-B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2-D1 16
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100217322 35
  • 52.61 (n)
  • 42.16 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC796419 35
  • 44.14 (n)
  • 34.36 (a)
Species with no ortholog for HLA-B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLA-B Gene

ENSEMBL:
Gene Tree for HLA-B (if available)
TreeFam:
Gene Tree for HLA-B (if available)

Paralogs for HLA-B Gene

Paralogs for HLA-B Gene

Selected SIMAP similar genes for HLA-B Gene using alignment to 6308 proteins: