V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

HLA-A Gene

protein-coding   GIFtS: 59

GC06P030020
major histocompatibility complex, class I, A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
A-1 3
A-10 3
A-28 3
A-9 3
Aw-19 3
Aw-24 3
Aw-33 3
Aw-34 3
Aw-36 3
Aw-43 3
Aw-66 3
Aw-68 3
Aw-69 3
Aw-74 3
Aw-80 3
FLJ26655 2
HLAA 2, 3
OTTHUMP00000161059 2
Descriptions
HLA class I histocompatibility antigen, A-23 alpha chain 2
MHC class I antigen A*1 3
MHC class I antigen A*11 3
MHC class I antigen A*2 3
MHC class I antigen A*23 3
MHC class I antigen A*24 3
MHC class I antigen A*25 3
MHC class I antigen A*26 3
MHC class I antigen A*29 3
MHC class I antigen A*3 3
MHC class I antigen A*30 3
MHC class I antigen A*31 3
MHC class I antigen A*32 3
MHC class I antigen A*33 3
MHC class I antigen A*34 3
MHC class I antigen A*36 3
MHC class I antigen A*43 3
MHC class I antigen A*66 3
MHC class I antigen A*68 3
MHC class I antigen A*69 3
MHC class I antigen A*74 3
MHC class I antigen A*80 3
MHC class I antigen HLA-A heavy chain 2
MHC leukocyte antigen 2
antigen presenting molecule 2
leucocyte antigen class I 2
leukocyte antigen class I-A 2
major histocompatibility complex, class I, A 2
External Ids
HGNC: 49311
Entrez Gene: 31052
UniProtKB: P304433
UniProtKB: P018923
UniProtKB: P044393
UniProtKB: P137463
UniProtKB: P304473
UniProtKB: P055343
UniProtKB: P184623
UniProtKB: P304503
UniProtKB: P305123
UniProtKB: P161883
UniProtKB: P161893
UniProtKB: P103143
UniProtKB: P161903
UniProtKB: P304533
UniProtKB: P304553
UniProtKB: P304563
UniProtKB: P304573
UniProtKB: P018913
UniProtKB: P103163
UniProtKB: P304593
UniProtKB: Q091603
Search outside databases for aliases for HLA-A gene

Previous GC identifers: GC06P029953 GC06P029626 GC06P029902 GC06P030016 GC06P030019

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HLA-A:
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer
consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored
in the membrane. Class I molecules play a central role in the immune system by presenting peptides
derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy
chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide,
exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes
the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the
cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding
specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone
marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by
RefSeq]

UniProtKB/Swiss-Prot: 1A80_HUMAN, Q09160
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HLA-A gene  

Entrez Gene cytogenetic band: 6p21.3   HGNC cytogenetic band: 6p21.3

HLA-A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030020:     (about GC identifiers)

Start:
30,018,310 bp from pter
End:
30,021,633 bp from pter
Size:
3,324 bases
Orientation:
plus strand
RefSeq DNA sequence:
NT_113893.1  NC_000006.10  NT_007592.14  NT_113891.1  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 1A01_HUMAN, P30443 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, A-1 alpha chain precursor  
Size: 365 amino acids; 40846 Da
Subunit: Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human
herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structure from and Proteopedia :
1W72 (3D)    3BO8 (3D)    
Secondary accessions: O77964 O78171 Q9MYA3 Q9TP25 Q9TQP5

UniProtKB/Swiss-Prot: 1A02_HUMAN, P01892 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-2 alpha chain precursor  
Size: 365 amino acids; 40922 Da
Subunit: Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human
herpesvirus 8 MIR1 protein. Interacts with HTLV-1 accessory protein p12I
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAA41022.1; Type=Miscellaneous discrepancy; Note=The sequence differs
from that shown extensively;
PDB structures from and Proteopedia :
1AKJ (3D)    1AO7 (3D)    1AQD (3D)    1B0G (3D)    1B0R (3D)    1BD2 (3D)    1DUY (3D)    1DUZ (3D)    
1EEY (3D)    1EEZ (3D)    1HHG (3D)    1HHH (3D)    1HHI (3D)    1HHJ (3D)    1HHK (3D)    1HLA (3D)    
1I1F (3D)    1I1Y (3D)    1I4F (3D)    1I7R (3D)    1I7T (3D)    1I7U (3D)    1IM3 (3D)    1JF1 (3D)    
1JHT (3D)    1LP9 (3D)    1OGA (3D)    1P7Q (3D)    1QEW (3D)    1QR1 (3D)    1QRN (3D)    1QSE (3D)    
1QSF (3D)    1S8D (3D)    1S9W (3D)    1S9X (3D)    1S9Y (3D)    1T1W (3D)    1T1X (3D)    1T1Y (3D)    
1T1Z (3D)    1T20 (3D)    1T21 (3D)    1T22 (3D)    1TVB (3D)    1TVH (3D)    1UR7 (3D)    2AV1 (3D)    
2AV7 (3D)    2BNQ (3D)    2BNR (3D)    2C7U (3D)    2CLR (3D)    2F53 (3D)    2F54 (3D)    2GIT (3D)    
2GJ6 (3D)    2GT9 (3D)    2GTW (3D)    2GTZ (3D)    2GUO (3D)    2J8U (3D)    2JCC (3D)    2P5E (3D)    
2P5W (3D)    2PYE (3D)    2UWE (3D)    2V2W (3D)    2V2X (3D)    2VLJ (3D)    2VLK (3D)    2VLL (3D)    
2VLR (3D)    3BGM (3D)    3BH8 (3D)    3BH9 (3D)    3BHB (3D)    3D25 (3D)    3FQN (3D)    3FQR (3D)    
3FQT (3D)    3FQU (3D)    3FQW (3D)    3FQX (3D)    3FT2 (3D)    3FT3 (3D)    3FT4 (3D)    3GJF (3D)    
3HAE (3D)    3HLA (3D)    
Secondary accessions: O19619 P06338 P10313 P30444 P30445 P30446 P30514 Q29680 Q29837 Q29899 Q95352
Q95380 Q9TPX8 Q9TPX9 Q9TPY0 Q9TQH5 Q9TQI3

UniProtKB/Swiss-Prot: 1A03_HUMAN, P04439 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-3 alpha chain precursor  
Size: 365 amino acids; 40841 Da
Subunit: Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human
herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19546 O19756 Q65A82 Q9GJE6 Q9GJE7 Q9GJE8 Q9MYE6 Q9MYG4 Q9TPR8

UniProtKB/Swiss-Prot: 1A11_HUMAN, P13746 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-11 alpha chain precursor  
Size: 365 amino acids; 40937 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
1Q94 (3D)    1QVO (3D)    1X7Q (3D)    2HN7 (3D)    
Secondary accessions: O19605 O19606 Q29747 Q29835 Q9BCN0 Q9MYI5 Q9TQE9 Q9TQP6 Q9TQP7
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A23_HUMAN, P30447 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-23 alpha chain precursor  
Size: 365 amino acids; 40733 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9TQF1 Q9TQF8 Q9TQG5 Q9TQM6
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A24_HUMAN, P05534 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-24 alpha chain precursor  
Size: 365 amino acids; 40689 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
2BCK (3D)    
Secondary accessions: P30448 P30449 Q29908 Q29909 Q29910 Q95355
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A25_HUMAN, P18462 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-25 alpha chain precursor  
Size: 365 amino acids; 41218 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q95362 Q9TQE8 Q9TQG0 Q9UQU3
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A26_HUMAN, P30450 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-26 alpha chain precursor  
Size: 365 amino acids; 41062 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02963 O78073 P79563 Q30208 Q31623 Q95377 Q9BD15 Q9BD19 Q9MW42 Q9TQK5
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A29_HUMAN, P30512 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-29 alpha chain precursor  
Size: 365 amino acids; 40863 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02955 O19687 O98011 P30451 P79562
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A30_HUMAN, P16188 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-30 alpha chain precursor  
Size: 365 amino acids; 40905 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19598 O62921 P30452 Q9UIP7
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A31_HUMAN, P16189 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-31 alpha chain precursor  
Size: 365 amino acids; 41004 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O62924 O98009 O98137 Q8MHM1 Q9TPQ3 Q9TQ24 Q9UQU6 Q9UQU7
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A32_HUMAN, P10314 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-32 alpha chain precursor  
Size: 365 amino acids; 41048 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O77937 Q29838 Q8MHN9 Q9MYE9 Q9MYG5 Q9TQF5 Q9TQF9
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A33_HUMAN, P16190 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-33 alpha chain precursor  
Size: 365 amino acids; 40892 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02939 O02954
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A34_HUMAN, P30453 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-34 alpha chain precursor  
Size: 365 amino acids; 41055 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: P30454
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A36_HUMAN, P30455 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-36 alpha chain precursor  
Size: 365 amino acids; 40934 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9MY89
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A43_HUMAN, P30456 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-43 alpha chain precursor  
Size: 365 amino acids; 41033 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19509
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A66_HUMAN, P30457 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-66 alpha chain precursor  
Size: 365 amino acids; 41082 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: P30458
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-68 alpha chain precursor  
Size: 365 amino acids; 40909 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
1HSB (3D)    1TMC (3D)    2HLA (3D)    
Secondary accessions: O19673 O19695 O19794 O19795 O43907 O77938 O98010 P10315 P79505 Q9MYA5 Q9MYC4
Q9TQG7 Q9TQN5 Q9UIN2
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-69 alpha chain  
Size: 365 amino acids; 40977 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B1PKZ3
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A74_HUMAN, P30459 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-74 alpha chain precursor  
Size: 365 amino acids; 40891 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19647 O43906 O46874 Q95IZ5 Q9UIN1
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

UniProtKB/Swiss-Prot: 1A80_HUMAN, Q09160 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-80 alpha chain precursor  
Size: 365 amino acids; 40792 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with
human herpesvirus 8 MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   

Post-translational modifications:

  • Sulfated. Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8
    MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By
    similarity)1
  • Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1
    protein. This targets the protein for rapid degradation via the ubiquitin system1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein.
    This targets the protein for rapid degradation via the ubiquitin system (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002107.3  
    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (HLA Class I A2 A28, HLA Class 1 A30 A31, HLA Class 1 A25, HLA Class 1 A2, A3, A29, HLA Class I A33 B8, HLA Class I A1 A36, HLA Class 1 A25, A26, A34, HLA Class 1 A2, A25, A32, HLA Class 1 A1, A11, A26, HLA Class I A11, HLA Class 1 A2, B5, HLA Class 1 ABC, HLA A2, HLA Class 1 A34, B71, A26 , HLA Class I A3, MHC TsH 2s p q, HLA Class 1 A25, A26, MHC class I, MHC Class I alpha, HLA A25 + HLA Aw32, HLA Class I, HLA Class 1 Bw4, A9, A32)
    Human Recombinant Proteins from Abnova (HLA-A)
                  OriGene Purified Recombinant Human Protein: HLA-A 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139 Golgi membrane EXP15569716
    GO:0005887 integral to plasma membrane NAS1431115 2437024 2715640 6609814 8188325
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    GO:0031901 early endosome membrane EXP15569716
    About this table

    Antibodies for HLA-A: 
    Invitrogen Antibodies for HLA-A
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for HLA-A
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (HLA Class I A2 A28, HLA Class 1 A30 A31, HLA Class 1 A25, HLA Class 1 A2, A3, A29, HLA Class I A33 B8, HLA Class I A1 A36, HLA Class 1 A25, A26, A34, HLA Class 1 A2, A25, A32, HLA Class 1 A1, A11, A26, HLA Class I A11, HLA Class 1 A2, B5, HLA Class 1 ABC, HLA A2, HLA Class 1 A34, B71, A26 , HLA Class I A3, MHC TsH 2s p q, HLA Class 1 A25, A26, MHC class I, MHC Class I alpha, HLA A25 + HLA Aw32, HLA Class I, HLA Class 1 Bw4, A9, A32), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (HLA-A)
    Novus Biologicals Antibodies for HLA-A

    Assays for HLA-A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR007110 Ig-like
     IPR003006 Ig/MHC_CS
     IPR011161 MHC_I-like_Ag-recog
     IPR001039 MHC_I_a_a1/a2
     IPR013783 Ig-like_fold


       GeneDecks  HLA-A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P30443
    Graphical View of Domain Structure for InterPro Entry P01892
    Graphical View of Domain Structure for InterPro Entry P04439
    Graphical View of Domain Structure for InterPro Entry P13746
    Graphical View of Domain Structure for InterPro Entry P30447
    Graphical View of Domain Structure for InterPro Entry P05534
    Graphical View of Domain Structure for InterPro Entry P18462
    Graphical View of Domain Structure for InterPro Entry P30450
    Graphical View of Domain Structure for InterPro Entry P30512
    Graphical View of Domain Structure for InterPro Entry P16188
    Graphical View of Domain Structure for InterPro Entry P16189
    Graphical View of Domain Structure for InterPro Entry P10314
    Graphical View of Domain Structure for InterPro Entry P16190
    Graphical View of Domain Structure for InterPro Entry P30453
    Graphical View of Domain Structure for InterPro Entry P30455
    Graphical View of Domain Structure for InterPro Entry P30456
    Graphical View of Domain Structure for InterPro Entry P30457
    Graphical View of Domain Structure for InterPro Entry P01891
    Graphical View of Domain Structure for InterPro Entry P10316
    Graphical View of Domain Structure for InterPro Entry P30459
    Graphical View of Domain Structure for InterPro Entry Q09160

    ProtoNet protein and cluster: P30443

    3 Blocks protein families:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1A01_HUMAN, P30443
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A02_HUMAN, P01892
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A03_HUMAN, P04439
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A11_HUMAN, P13746
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A23_HUMAN, P30447
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A24_HUMAN, P05534
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A25_HUMAN, P18462
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A26_HUMAN, P30450
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A29_HUMAN, P30512
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A30_HUMAN, P16188
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A31_HUMAN, P16189
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A32_HUMAN, P10314
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A33_HUMAN, P16190
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A34_HUMAN, P30453
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A36_HUMAN, P30455
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A43_HUMAN, P30456
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A66_HUMAN, P30457
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A74_HUMAN, P30459
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A80_HUMAN, Q09160
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (HLA-A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HLA-A)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC008611

                  Applied Biosystems Silencer® siRNAs for HLA-A

                  Sigma-Aldrich siRNA for HLA-A  
                         Sigma-Aldrich shRNA Panels and shRNA for HLA-A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for HLA-A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002116
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002116
                                     untagged cDNA clones in CMV expression vector (see all 5): BC003069 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: BC019236

    UniProtKB/Swiss-Prot: 1A01_HUMAN, P30443
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A02_HUMAN, P01892
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A03_HUMAN, P04439
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A11_HUMAN, P13746
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A23_HUMAN, P30447
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A24_HUMAN, P05534
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A25_HUMAN, P18462
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A26_HUMAN, P30450
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A29_HUMAN, P30512
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A30_HUMAN, P16188
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A31_HUMAN, P16189
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A32_HUMAN, P10314
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A33_HUMAN, P16190
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A34_HUMAN, P30453
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A36_HUMAN, P30455
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A43_HUMAN, P30456
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A66_HUMAN, P30457
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A74_HUMAN, P30459
    Function: Involved in the presentation of foreign antigens to the immune system

    UniProtKB/Swiss-Prot: 1A80_HUMAN, Q09160
    Function: Involved in the presentation of foreign antigens to the immune system

    Genatlas biochemistry entry for HLA-A:
    HLA-A,alpha chain,44kDa,class Ia ,ubiquitously expressed,except central nervous
    system,placenta,sperm cells (see MHC1)

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI12414957 17353931
    GO:0032393 MHC class I receptor activity NAS1431115 2437024 2715640 6609814 8188325
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for HLA-A
     Immune response Antigen presentation by MHC class I

       GeneDecks  HLA-A for the pathways selected above  
    About GeneDecksing

    5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for  HLA-A  (Your Favorite Gene powered by Ingenuity) (see all 9
     Type I Diabetes Mellitus Signaling
     Protein Ubiquitination Pathway
     Allograft Rejection Signaling
     Caveolar-mediated Endocytosis
     Antigen Presentation Pathway

       GeneDecks  HLA-A for the pathways selected above  
    About GeneDecksing

    5/7 Kegg Pathways  (Kegg details for HLA-A) (see all 7 ):
     hsa04514 Cell adhesion molecules (CAMs)
     hsa04612 Antigen processing and presentation
     hsa04650 Natural killer cell mediated cytotoxicity
     hsa04940 Type I diabetes mellitus
     hsa05320 Autoimmune thyroid disease

       GeneDecks  HLA-A for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  HLA-A 


    5/8 Interacting proteins for HLA-A (P161881, 2 P018911, 2 P304551, 2 P304571, 2 P044391, 2 P304501, 2 P018921, 2 P304431, 2) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UGCGL1Q9NYU21EBI-1042870, EBI-1056389 EBI-1042870, EBI-1056389
    B2MP617692MINT-24957 MINT-24957
    HLA-AP161881EBI-1050524, EBI-1049899 EBI-1044129, EBI-1042870 EBI-1049899, EBI-1053495 EBI-1042870, EBI-1044129 EBI-1049899, EBI-1050524 EBI-1049899, EBI-1050350 EBI-1050524, EBI-1049899 EBI-1050524, EBI-1049899 EBI-1042870, EBI-1044129
    PDIA3P301012MINT-4653981
    --P115982MINT-4653997 MINT-4787168
    --P355652MINT-4653997 MINT-4787168
    --P069272MINT-6733796
    --Q1HVH92MINT-6769747
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA--
    GO:0006955 immune response NAS1431115 2437024 2715640 6609814 8188325
    GO:0019882 antigen processing and presentation IEA--
    GO:0044419 interspecies interaction between organisms IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for HLA-A
    6 Novoseek chemical compound relationships for HLA-A gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dr-10 62.25 2 8754259 (1), 15682656 (1)
    tyrosine 4.97 1 8976179 (1)
    oligonucleotide 2.67 5 7883594 (2), 18244920 (1), 17927716 (1), 18282752 (1)
    calcium 0.53 2 15375555 (1), 11369189 (1)
    p002 0.00 1 15150599 (1)
    zinc 0.00 1 8233798 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (HLA-A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HLA-A)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC008611

                  Sigma-Aldrich siRNA for HLA-A  
                         Sigma-Aldrich shRNA Panels and shRNA for HLA-A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002116  

    REFSEQ mRNAs for HLA-A gene: 

    NM_002116.5   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002116  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002116
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002116
                                     untagged cDNA clones in CMV expression vector (see all 5): BC003069 

    Additional cDNA sequence: 

    AF012767.1 U43335.1 

    24/169 DOTS entries (see all 169 ):

    DT.91783875  DT.95333141  DT.100046040  DT.95090280  DT.100733427  DT.91783982  DT.95376642  DT.92045303 
    DT.100855576  DT.95378900  DT.100733374  DT.100733433  DT.100733373  DT.91911697  DT.100799521  DT.100733391 
    DT.91783956  DT.100849442  DT.95137848  DT.95376774  DT.86995001  DT.91680045  DT.91787286  DT.95376858 

    24/65 AceView cDNA sequences (see all 65 ):

    CR608593 U32184 CR616547 CR590761 NM_002116 CR625955 CR590089 CR605752 
    CR600122 CR590229 CR609975 CR605841 CR621304 CR591238 CR604944 CR593473 
    CR600696 CR619034 CR597883 CR603931 CR592438 CR598559 CR622028 CR607566 

    highest scoring ESTs for HLA-A:

    AA055466 AA086044 AA132476 AA132748 AA133610 AA134054 AA146659 AA158459 AA161159 AA295259 

    Unigene Clusters for HLA-A:

    Major histocompatibility complex, class I, A
    Hs.181244  [show with all ESTs], Hs.713441  [show with all ESTs]
    Unigene Representative Sequences: AB209117, BE909674


    GeneLoc Exon Structure

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    HLA-A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for HLA-A

    1 / 2 / 3

    7 probe-sets matching HLA-A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    41237_at2, 3 U95-A 10 1.00 0.25 1.00 1.00 U07234 0.80 0.65 0.73 1

    213932_x_at2, 3 U133-A 16 1.00 0.50 -- -- AI923492 0.40 1.00 0.76 1

    215313_x_at2, 3 U133-A 22 1.00 0.22 -- -- AA573862 0.20 1.00 0.72 1

    221978_at2 U133-A 3 0.27 0.62 -- -- -- -- -- -- --

    213932_x_at2 U133Plus2 16 1.00 0.50 -- -- -- -- -- -- --

    215313_x_at2 U133Plus2 22 1.00 0.22 -- -- -- -- -- -- --

    221978_at2 U133Plus2 3 0.27 0.62 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.181244 Hs.713441

    Expression variation in blood from EXPOLDB for HLA-A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for HLA-A gene from 3 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    PATR-A1   -- major histocompatibility complex, class I, A 97.63(n)
    95.89(a)
    450151  NM_001009058.1  NP_001009058.1 
    cow
    (Bos taurus)
    MGC1344531   -- similar to HLA class I histocompatibility antigen, more 85.69(n)
    77.56(a)
    509597  NM_001038518.1  NP_001033607.1 
    mouse
    (Mus musculus)
    H2-Q101   -- histocompatibility 2, Q region locus 10 82.16(n)
    77.59(a)
    15007  NM_010391.3  NP_034521.1 
    About this table        Species with no ortholog for HLA-A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    UniProtKB/Swiss-Prot: 1A80_HUMAN, Q09160
    Polymorphism: The following alleles of A-1 are known: A*0101, A*0102, A*0103, A*0106 and A*0107.
    The sequence shown is that of A*0101
    Polymorphism: The following alleles of A-2 are known: A*0201, A*0202, A*0203, A*0204, A*0205,
    A*0206 (A2.4A), A*0207, A*0208, A*0209, A*0210, A*0211 (A2.5), A*0212, A*0213 (A*02SLU), A*0216,
    A*0217, A*0218 (A2K), A*0219, A*0220, A*0221, A*0231, A*0234 (A*AAT), A*0235, A*0236 and A*0237.
    The sequence shown is that of A*0201
    Polymorphism: The following alleles of A-3 are known: A*0301 (A-3.1), A*0302, A*0304 and A*0305.
    The sequence shown is that of A*0301
    Polymorphism: The following alleles of A-11 are known: A*1101 (A-11E), A*1102 (A-11K), A*1103,
    A*1104, A*1105 and A*1107. The sequence shown is that of A*1101
    Polymorphism: The following alleles of A-23 are known: A*2301, A*2302, A*2303, A*2304 and A*2305.
    The sequence shown is that of A*2301
    Polymorphism: The following alleles of A-24 are known: A*2401, A*2402, A*2403, A*2406, A*2408
    (A9HH), A*2410 (A*24JV), A*2413 (A*24YM), A*2414 (A*24SA) and A*2429. Allele A*2402 is represented
    in all major racial groups. Allele A*2406 and allele A*2413 are found in the Australian Aborigenal
    population. Allele A*2414 is found in individuals of South American descent. The sequence shown is
    that of A*2402
    Polymorphism: The following alleles of A-25 are known: A*2501 A*2502 and A*2503. The sequence shown
    is that of A*2501
    Polymorphism: The following alleles of A-26 are known: A*2601, A*2602, A*2603, A*2604 (A-10SA),
    A*2605, A*2607, A*2608, A*2612 and A*2615. The sequence shown is that of A*2601
    Polymorphism: The following alleles of A-29 are known: A*2901 (A29.1), A*2902 (A29.2), A*2903 and
    A*2904. The sequence shown is that of A*2901
    Polymorphism: The following alleles of A-30 are known: A*3001 (A30.3), A*3002, A*3003, A*3004
    (A30W7), A*3006, A*3007 and A*3008. The sequence shown is that of A*3001
    Polymorphism: The following alleles of A-31 are known: A*3101, A*3102, A*3103, A*3104, A*3105
    (A3101v1) and A*3106. The sequence shown is that of A*3101
    Polymorphism: The following alleles of A-32 are known: A*3201, A*3202, A*3203, A*3204, A*3205 and
    A*3206. The sequence shown is that of A*3201
    Polymorphism: The following alleles of A-33 are known: A*3301 (Aw-33.1), A*3302 and A*3303. The
    sequence shown is that of A*3301
    Polymorphism: The following alleles of A-34 are known: A*3401 (Aw-34.1) and A*3402 (Aw-34.2). The
    sequence shown is that of A*3401
    Polymorphism: The following alleles of A-36 are known: A*3601 and A*3602. The sequence shown is
    that of A*3601
    Polymorphism: The only allele of A-43 known is A*4301 which is shown here
    Polymorphism: The following alleles of A-66 are known: A*6601 and A*6602 (Aw67). The sequence shown
    is that of A*6601
    Polymorphism: The following alleles of A-68 are known: A*6801 (Aw68.1), A*6802, A*6803. A*6804,
    A*6805, A*6806, A*6807, A*6808, A*6809, A*6810, A*6816 and A*6817. The sequence shown is that of
    A*6801
    Polymorphism: The only allele of A-69 known is A*6901 which is shown here
    Polymorphism: The following alleles of A-74 are known: A*7401 A*7402, A*7403, A*7404 and A*7405.
    The sequence shown is that of A*7401
    Polymorphism: The only allele of A-80 known is A*8001 which is shown here


    10/590 NCBI SNPs in HLA-A are shown (see all 590 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 43)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs24991,2
    A,C,F,H30021521(-) ATACTC/AAGGTT 1 -- ut3113Minor allele frequency- A:0.07EU EA WA NS NA MN 1326
    --
    rs30941411,2
    A,C,F,H30017786(-) GCTTGC/ATCTGG 1 -- ng5112Minor allele frequency- A:0.06EU EA WA NS NA 1150
    --
    rs29168011,2
    A,C,F,H30018265(+) TAAAGT/CCCGCA 1 -- ng5112Minor allele frequency- C:0.11EU EA WA NS NA 1144
    --
    rs122022961,2
    A,C,F,H30016448(+) ctacaT/Ctgaca 1 -- ng514Minor allele frequency- C:0.30EU EA WA 418
    --
    rs10624051,2
    C,F,H30021488(+) AGCTGC/TAACTT 1 -- ut3111Minor allele frequency- T:0.01EU EA WA NA 914
    --
    rs25713821,2
    A,C,F30021706(+) TGTTCC/TGGCCA 1 -- ng313Minor allele frequency- T:0.08NA 138
    --
    rs78291,2
    A,C,F30021403(+) TGTGCC/TCCCTC 1 -- ut315Minor allele frequency- T:0.43MN NA 508
    --
    rs16328891,2
    A,C,F30017160(-) TAGATG/TGATGT 1 -- ng511Minor allele frequency- T:0.37MN 184
    --
    rs134881,2
    A,C30021617(+) TGGAAC/GACATG 1 -- ut310--------
    --
    rs16328861,2
    C,F30017198(-) TTAAAG/AGACAA 1 -- ng511Minor allele frequency- A:0.15MN 184
    About this table

    HapMap Linkage Disequilibrium images for HLA-A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 142800

    10/80 Novoseek disease relationships for HLA-A gene (see all 80 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    bare lymphocyte syndrome 48.64 1 8229525 (1)
    hepatitis autoimmune 46.08 1 2175292 (1)
    genetic susceptibility 40.00 2 15603871 (1), 16635082 (1)
    melanoma 39.02 26 7686817 (3), 11948496 (2), 10233766 (2), 10432284 (1) (see all 17)
    cholangitis primary sclerosing 38.20 1 7875491 (1)
    tumors 36.82 49 17538388 (2), 9286277 (2), 18422748 (2), 1849792 (1) (see all 39)
    immunodeficiency 34.25 12 15989466 (2), 12552458 (1), 18971252 (1), 17202219 (1) (see all 11)
    autoimmune diseases 33.68 2 16417220 (1), 9293772 (1)
    hepatitis c 25.46 4 14722889 (1), 1711000 (1), 7693568 (1), 18294939 (1)
    behcet disease 24.64 2 15529349 (2)
    About this table

    Human Gene Mutation Database: HLA-A
    Genetic Association Database: HLA-A
    Human Genome Epidemiology Navigator: HLA-A (2200 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/1137 PubMed articles for HLA-A gene (see all 1137 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 3105 HGNC: 4931 AceView: HLA-A euGenes: HUgn3105 ECgene: HLA-A
    H-InvDB: HLA-A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for HLA-A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for HLA-A-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for HLA-A Antibodies for HLA-A
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HLA-A Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (HLA-A)
     Antibodies (HLA-A)
     Chimera RNAi (HLA-A)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (HLA Class I A2 A28, HLA Class 1 A30 A31, HLA Class 1 A25, HLA Class 1 A2, A3, A29, HLA Class I A33 B8, HLA Class I A1 A36, HLA Class 1 A25, A26, A34, HLA Class 1 A2, A25, A32, HLA Class 1 A1, A11, A26, HLA Class I A11, HLA Class 1 A2, B5, HLA Class 1 ABC, HLA A2, HLA Class 1 A34, B71, A26 , HLA Class I A3, MHC TsH 2s p q, HLA Class 1 A25, A26, MHC class I, MHC Class I alpha, HLA A25 + HLA Aw32, HLA Class I, HLA Class 1 Bw4, A9, A32)
     Antibodies (HLA Class I A2 A28, HLA Class 1 A30 A31, HLA Class 1 A25, HLA Class 1 A2, A3, A29, HLA Class I A33 B8, HLA Class I A1 A36, HLA Class 1 A25, A26, A34, HLA Class 1 A2, A25, A32, HLA Class 1 A1, A11, A26, HLA Class I A11, HLA Class 1 A2, B5, HLA Class 1 ABC, HLA A2, HLA Class 1 A34, B71, A26 , HLA Class I A3, MHC TsH 2s p q, HLA Class 1 A25, A26, MHC class I, MHC Class I alpha, HLA A25 + HLA Aw32, HLA Class I, HLA Class 1 Bw4, A9, A32)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for HLA-A




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for HLA-A

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    HLA-A Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com