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HLA-A Gene

protein-coding   GIFtS: 69
GCID: GC06P030186

Major Histocompatibility Complex, Class I, A

  See HLA-A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class I, A1 2     MHC Class I Antigen A*113
HLAA2 3     MHC Class I Antigen A*23
HLA Class I Histocompatibility Antigen, A-1 Alpha Chain2 3     MHC Class I Antigen A*233
Antigen Presenting Molecule2     MHC Class I Antigen A*243
Leukocyte Antigen Class I-A2     MHC Class I Antigen A*253
MHC Class I Antigen HLA-A Heavy Chain2     MHC Class I Antigen A*263
Aw-193     MHC Class I Antigen A*293
Aw-243     MHC Class I Antigen A*33
Aw-333     MHC Class I Antigen A*303
Aw-343     MHC Class I Antigen A*313
Aw-363     MHC Class I Antigen A*323
Aw-433     MHC Class I Antigen A*333
Aw-663     MHC Class I Antigen A*343
Aw-683     MHC Class I Antigen A*363
Aw-693     MHC Class I Antigen A*433
Aw-743     MHC Class I Antigen A*663
Aw-803     MHC Class I Antigen A*683
HLA Class I Histocompatibility Antigen, A-10 Alpha Chain3     MHC Class I Antigen A*693
HLA Class I Histocompatibility Antigen, A-28 Alpha Chain3     MHC Class I Antigen A*743
HLA Class I Histocompatibility Antigen, A-9 Alpha Chain3     MHC Class I Antigen A*803
MHC Class I Antigen A*13     

External Ids:    HGNC: 49311   Entrez Gene: 31052   Ensembl: ENSG000002065037   OMIM: 1428005   UniProtKB: P304433   
UniProtKB: P018923   UniProtKB: P044393   UniProtKB: P137463   UniProtKB: P304473   UniProtKB: P055343   
UniProtKB: P184623   UniProtKB: P304503   UniProtKB: P305123   UniProtKB: P161883   UniProtKB: P161893   
UniProtKB: P103143   UniProtKB: P161903   UniProtKB: P304533   UniProtKB: P304553   UniProtKB: P304563   
UniProtKB: P304573   UniProtKB: P018913   UniProtKB: P103163   UniProtKB: P304593   UniProtKB: Q091603   

Export aliases for HLA-A gene to outside databases

Previous GC identifers: GC06P029953 GC06P029626 GC06P029902 GC06P030016 GC06P030019 GC06P030020 GC06P029916 GC06P029918 GC06P029921 GC06P029933 GC06P029949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-A Gene:
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a
heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I
molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum
lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8
exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the
peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the
cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of
each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney
transplantation. Hundreds of HLA-A alleles have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-A Gene:
HLA-A (major histocompatibility complex, class I, A) is a protein-coding gene. Diseases associated with HLA-A include hypersensitivity syndrome, carbamazepine-induced, and birdshot chorioretinopathy. GO annotations related to this gene include peptide antigen binding and receptor binding. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: 1A01_HUMAN, P30443 (see all)
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_167247.2  NT_167245.2  NT_167246.2  NT_167248.2  NT_167249.2  NC_018917.2  NT_113891.3  NT_167244.2  
NC_000006.11  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-A gene promoter:
         AML1a   AP-1   ATF-2   MyoD   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-A promoter sequence
   Search Chromatin IP Primers for HLA-A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030186:  view genomic region     (about GC identifiers)

Start:
29,909,037 bp from pter      End:
29,913,661 bp from pter
Size:
4,625 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167244 1,150,133-1,153,548      Chr6+,NT_167245 1,203,608-1,207,037      Chr6+,NT_167246 1,202,632-1,206,062     
Chr6+,NT_167248 1,203,025-1,206,454      Chr6+,NT_167249 1,239,582-1,243,012      Chr6+,NT_167247 1,292,221-1,295,564     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: 1A01_HUMAN, P30443 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, A-1 alpha chain precursor  
Size: 365 amino acids; 40846 Da
Subunit: Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
4 PDB 3D structures from and Proteopedia for HLA-A:
1W72 (3D)        3BO8 (3D)        4NQV (3D)        4NQX (3D)    
Secondary accessions: O77964 O78171 Q9MYA3 Q9TP25 Q9TQP5

UniProtKB/Swiss-Prot: 1A02_HUMAN, P01892 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-2 alpha chain precursor  
Size: 365 amino acids; 40922 Da
Subunit: Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein. Interacts with HTLV-1 accessory protein p12I
Sequence caution: Sequence=CAA41022.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown
extensively;
Selected PDB 3D structures from and Proteopedia for HLA-A (see all 182):
1AKJ (3D)        1AO7 (3D)        1AQD (3D)        1B0G (3D)        1B0R (3D)        1BD2 (3D)    
Secondary accessions: O19619 P06338 P10313 P30444 P30445 P30446 P30514 Q29680 Q29837 Q29899
Q95352 Q95380 Q9TPX8 Q9TPX9 Q9TPY0 Q9TQH5 Q9TQI3

UniProtKB/Swiss-Prot: 1A03_HUMAN, P04439 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-3 alpha chain precursor  
Size: 365 amino acids; 40841 Da
Subunit: Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein (By similarity)
3 PDB 3D structures from and Proteopedia for HLA-A:
2XPG (3D)        3RL1 (3D)        3RL2 (3D)    
Secondary accessions: O19546 O19756 Q65A82 Q9GJE6 Q9GJE7 Q9GJE8 Q9MYE6 Q9MYG4 Q9TPR8

UniProtKB/Swiss-Prot: 1A11_HUMAN, P13746 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-11 alpha chain precursor  
Size: 365 amino acids; 40937 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
4 PDB 3D structures from and Proteopedia for HLA-A:
1Q94 (3D)        1QVO (3D)        1X7Q (3D)        2HN7 (3D)    
Secondary accessions: O19605 O19606 Q29747 Q29835 Q5S3G1 Q9BCN0 Q9MYI5 Q9TQE9 Q9TQP6 Q9TQP7
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A23_HUMAN, P30447 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-23 alpha chain precursor  
Size: 365 amino acids; 40733 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q9TQF1 Q9TQF8 Q9TQG5 Q9TQM6
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A24_HUMAN, P05534 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-24 alpha chain precursor  
Size: 365 amino acids; 40689 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Selected PDB 3D structures from and Proteopedia for HLA-A (see all 15):
2BCK (3D)        3I6L (3D)        3NFN (3D)        3QZW (3D)        3VXM (3D)        3VXN (3D)    
Secondary accessions: P30448 P30449 Q29908 Q29909 Q29910 Q95355
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A25_HUMAN, P18462 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-25 alpha chain precursor  
Size: 365 amino acids; 41218 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q95362 Q9TQE8 Q9TQG0 Q9UQU3
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A26_HUMAN, P30450 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-26 alpha chain precursor  
Size: 365 amino acids; 41062 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02963 O78073 P79563 Q30208 Q31623 Q95377 Q9BD15 Q9BD19 Q9MW42 Q9TQK5
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A29_HUMAN, P30512 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-29 alpha chain precursor  
Size: 365 amino acids; 40863 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02955 O19687 O98011 P30451 P79562
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A30_HUMAN, P16188 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-30 alpha chain precursor  
Size: 365 amino acids; 40905 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19598 O62921 P30452 Q9UIP7
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A31_HUMAN, P16189 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-31 alpha chain precursor  
Size: 365 amino acids; 41004 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O62924 O98009 O98137 Q8MHM1 Q9TPQ3 Q9TQ24 Q9UQU6 Q9UQU7
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A32_HUMAN, P10314 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-32 alpha chain precursor  
Size: 365 amino acids; 41048 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O77937 Q29838 Q8MHN9 Q9MYE9 Q9MYG5 Q9TQF5 Q9TQF9
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A33_HUMAN, P16190 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-33 alpha chain precursor  
Size: 365 amino acids; 40892 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02939 O02954
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A34_HUMAN, P30453 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-34 alpha chain precursor  
Size: 365 amino acids; 41055 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: P30454
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A36_HUMAN, P30455 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-36 alpha chain precursor  
Size: 365 amino acids; 40934 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: Q9MY89
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A43_HUMAN, P30456 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-43 alpha chain precursor  
Size: 365 amino acids; 41033 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19509
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A66_HUMAN, P30457 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-66 alpha chain precursor  
Size: 365 amino acids; 41082 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: P30458
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-68 alpha chain precursor  
Size: 365 amino acids; 40909 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
6 PDB 3D structures from and Proteopedia for HLA-A:
1HSB (3D)        1TMC (3D)        2HLA (3D)        4HWZ (3D)        4HX1 (3D)        4I48 (3D)    
Secondary accessions: O19673 O19695 O19794 O19795 O43907 O77938 O98010 P10315 P79505 Q9MYA5
Q9MYC4 Q9TQG7 Q9TQN5 Q9UIN2
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-69 alpha chain precursor  
Size: 365 amino acids; 40977 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: B1PKZ3
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A74_HUMAN, P30459 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-74 alpha chain precursor  
Size: 365 amino acids; 40891 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O19647 O43906 O46874 Q95IZ5 Q9UIN1
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

UniProtKB/Swiss-Prot: 1A80_HUMAN, Q09160 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-80 alpha chain precursor  
Size: 365 amino acids; 40792 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Alternative splicing: 2 isoforms:  P13746-1   P13746-2   (Only produced by allele A*1103)

Explore the universe of human proteins at neXtProt for HLA-A: NX_Q09160

Explore proteomics data for HLA-A at MOPED

Post-translational modifications: 

  • Sulfated1
  • Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets
    the protein for rapid degradation via the ubiquitin system (By similarity)1
  • Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets
    the protein for rapid degradation via the ubiquitin system1
  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the
    protein for rapid degradation via the ubiquitin system (By similarity)1
  • Ubiquitination2 at Lys92, Lys145, Lys168, Lys170, Lys200, Lys267, Lys292, Lys340
  • Glycosylation2 at Asn110
  • Modification sites at PhosphoSitePlus

  • See HLA-A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229687.1  NP_002107.3  

    ENSEMBL proteins: 
     ENSP00000379873   ENSP00000366002   ENSP00000365998   ENSP00000366005  
    Reactome Protein details: P30447 P01891 P16188 P30457 P30455 P18462 P04439 P16189 P30450 Q09160 P30459 P30512 P30453 P16190 P13746 P10314 P05534 P30443 P01892 P30456 P10316

    HLA-A Human Recombinant Protein Products:

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    OriGene Purified Protein for HLA-A
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HLA-A 

     
    antibodies-online proteins for HLA-A (3 products) 

     
    Search antibodies-online for peptides for HLA-A

    HLA-A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-A
    R&D Systems Antibodies for HLA-A (HLA Class I)
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    OriGene Custom Antibody Services for HLA-A
    Novus Biologicals HLA-A Antibodies
    Abcam antibodies for HLA-A (P30499, O15506, P01891, P10314, P04439, P16189, P30450, Q5MCQ6, P30459, P01892, P30512, P01889, P16190, P13746, P04222)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HLA-A
    antibodies-online antibodies for HLA-A (98 products) 

    HLA-A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    antibodies-online kits for HLA-A (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P30443
    Graphical View of Domain Structure for InterPro Entry P01892
    Graphical View of Domain Structure for InterPro Entry P04439
    Graphical View of Domain Structure for InterPro Entry P13746
    Graphical View of Domain Structure for InterPro Entry P30447
    Graphical View of Domain Structure for InterPro Entry P05534
    Graphical View of Domain Structure for InterPro Entry P18462
    Graphical View of Domain Structure for InterPro Entry P30450
    Graphical View of Domain Structure for InterPro Entry P30512
    Graphical View of Domain Structure for InterPro Entry P16188
    Graphical View of Domain Structure for InterPro Entry P16189
    Graphical View of Domain Structure for InterPro Entry P10314
    Graphical View of Domain Structure for InterPro Entry P16190
    Graphical View of Domain Structure for InterPro Entry P30453
    Graphical View of Domain Structure for InterPro Entry P30455
    Graphical View of Domain Structure for InterPro Entry P30456
    Graphical View of Domain Structure for InterPro Entry P30457
    Graphical View of Domain Structure for InterPro Entry P01891
    Graphical View of Domain Structure for InterPro Entry P10316
    Graphical View of Domain Structure for InterPro Entry P30459
    Graphical View of Domain Structure for InterPro Entry Q09160

    ProtoNet protein and cluster: P30443

    3 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1A01_HUMAN, P30443
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A02_HUMAN, P01892
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A03_HUMAN, P04439
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A11_HUMAN, P13746
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A23_HUMAN, P30447
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A24_HUMAN, P05534
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A25_HUMAN, P18462
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A26_HUMAN, P30450
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A29_HUMAN, P30512
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A30_HUMAN, P16188
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A31_HUMAN, P16189
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A32_HUMAN, P10314
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A33_HUMAN, P16190
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A34_HUMAN, P30453
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A36_HUMAN, P30455
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A43_HUMAN, P30456
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A66_HUMAN, P30457
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A74_HUMAN, P30459
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A80_HUMAN, Q09160
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with HLA-A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 1A01_HUMAN, P30443 (see all)
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-A:
    HLA-A,alpha chain,44kDa,class Ia ,ubiquitously expressed,except central nervous system,placenta,sperm cells (see
    MHC1)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI19124746
    GO:0005515protein binding IPI12414957
    GO:0042605peptide antigen binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046977TAP binding IDA8617941
         
    Find genes that share ontologies with HLA-A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HLA-A

    miRNA
    Products:
        
    miRTarBase miRNAs that target HLA-A:
    hsa-mir-148b-3p (MIRT019424), hsa-mir-124-3p (MIRT022132), hsa-mir-183-5p (MIRT025003), hsa-mir-615-3p (MIRT040433), hsa-mir-9-5p (MIRT021411)

    Block miRNA regulation of human, mouse, rat HLA-A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate HLA-A:
    hsa-miR-152 hsa-miR-148b hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidHLA-A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-A
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-A

    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-A (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-A (NM_002116)
    Sino Biological Human cDNA Clone for HLA-A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-A
    Addgene plasmids for HLA-A 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HLA-A
    Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1A01_HUMAN, P30443: Membrane; Single-pass type I membrane protein
    1A02_HUMAN, P01892: Membrane; Single-pass type I membrane protein
    1A03_HUMAN, P04439: Membrane; Single-pass type I membrane protein
    1A11_HUMAN, P13746: Membrane; Single-pass type I membrane protein
    1A23_HUMAN, P30447: Membrane; Single-pass type I membrane protein
    1A24_HUMAN, P05534: Membrane; Single-pass type I membrane protein
    1A25_HUMAN, P18462: Membrane; Single-pass type I membrane protein
    1A26_HUMAN, P30450: Membrane; Single-pass type I membrane protein
    1A29_HUMAN, P30512: Membrane; Single-pass type I membrane protein
    1A30_HUMAN, P16188: Membrane; Single-pass type I membrane protein
    1A31_HUMAN, P16189: Membrane; Single-pass type I membrane protein
    1A32_HUMAN, P10314: Membrane; Single-pass type I membrane protein
    1A33_HUMAN, P16190: Membrane; Single-pass type I membrane protein
    1A34_HUMAN, P30453: Membrane; Single-pass type I membrane protein
    1A36_HUMAN, P30455: Membrane; Single-pass type I membrane protein
    1A43_HUMAN, P30456: Membrane; Single-pass type I membrane protein
    1A66_HUMAN, P30457: Membrane; Single-pass type I membrane protein
    1A68_HUMAN, P01891: Membrane; Single-pass type I membrane protein
    1A69_HUMAN, P10316: Membrane; Single-pass type I membrane protein
    1A74_HUMAN, P30459: Membrane; Single-pass type I membrane protein
    1A80_HUMAN, Q09160: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    plasma membrane4
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS6609814
    GO:0009986cell surface IDA--
    GO:0012507ER to Golgi transport vesicle membrane TAS--

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HLA-A About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Proteasome Degradation0.57
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    Immune response Antigen presentation by MHC class I0.68
    3Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.76
    Nef mediated downregulation of MHC class I complex cell surface expression0.00
    The role of Nef in HIV-1 replication and disease pathogenesis0.76
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41


    Find genes that share SuperPaths with HLA-A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-A
        CDC42 Pathway
    CTL Mediated Apoptosis

    1 GeneGo (Thomson Reuters) Pathway for HLA-A
        Immune response Antigen presentation by MHC class I

    5 BioSystems Pathways for HLA-A
        Allograft Rejection
    Proteasome Degradation
    IL12-mediated signaling events
    TCR signaling in naive CD8+ T cells
    Downstream signaling in naive CD8+ T cells

    1 Sino Biological Pathway for HLA-A
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for HLA-A (see all 7)
        Endosomal/Vacuolar pathway
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for HLA-A) (see all 14):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-A: 
              Innate & Adaptive Immune Responses in human mouse rat
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HLA-A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HLA-A (P018912, 3 ENSP000003660054 P044392, 3 P018922, 3 P304432, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, ENSP000003002894MINT-4653981 STRING: ENSP00000300289
    ANXA6P081332MINT-8407259 MINT-8407185
    B2MP617692, ENSP000003408584MINT-24957 STRING: ENSP00000340858
    CD81P600332MINT-8407259 MINT-8407185
    CD9P219262MINT-8407259 MINT-8407185
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0002486antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IDA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-A (1A80)

    1 DrugBank Compound for HLA-A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-Indolebutyric Acid-- 133-32-4target--10592235

    Selected Novoseek inferred chemical compound relationships for HLA-A gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dr-10 61.2 2 8754259 (1), 15682656 (1)
    5-aza-2'deoxycytidine 30.7 3 17545540 (1), 19785955 (1), 20480522 (1)
    levamisole 6.25 2 7707435 (1), 7674325 (1)
    zinc 5.4 1 8233798 (1)
    tyrosine 4.43 1 8976179 (1)
    alanine 0.813 1 14999597 (1)
    calcium 0.525 2 15375555 (1), 11369189 (1)
    ursodeoxycholic acid 0.505 1 1505913 (1)
    oligonucleotide 0.408 5 7883594 (2), 18244920 (1), 17927716 (1), 18282752 (1)
    p002 0 1 15150599 (1)

    3 PharmGKB related drug/compound annotations for HLA-A gene    About this table
    Drug/compound PharmGKB Annotation
    allopurinolCA  
    carbamazepine  CA  
    zonisamideCA  



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HLA-A gene (2 alternative transcripts): 
    NM_001242758.1  NM_002116.7  

    Unigene Cluster for HLA-A:

    Major histocompatibility complex, class I, A
    Hs.181244  [show with all ESTs]
    Unigene Representative Sequence: AB209117
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396634(uc003nol.3) ENST00000376806 ENST00000496081(uc021ytz.1 uc011dmd.2)
    ENST00000376802 ENST00000495183(uc011dmc.2) ENST00000479320(uc003nok.3 uc010klp.2)
    ENST00000461903(uc010jrq.3) ENST00000376809
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HLA-A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate HLA-A:
    hsa-miR-152 hsa-miR-148b hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidHLA-A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HLA-A
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-A
    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-A (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-A (NM_002116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-A
    Addgene plasmids for HLA-A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-A
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-A
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-A
      QuantiFast Probe-based Assays in human, mouse, rat HLA-A

    Additional mRNA sequence: 

    AB209117.1 AF008933.1 AF012766.1 AF015930.1 AF036921.1 AF116214.1 AF116215.1 AF140506.1 
    AF165065.1 AF217560.1 AF217561.1 AF287958.1 AF287959.1 AF305699.2 AJ000661.1 AJ001269.1 
    AJ001274.1 AJ002678.1 AJ223060.1 AJ249241.1 AJ290394.2 AJ580771.1 AK027084.1 AK125608.1 
    AK130148.1 AK130153.1 AK130165.1 AK225789.1 AK296091.1 AK301014.1 AK301019.1 AK301282.1 
    AK304472.1 AK309533.1 AK310047.1 AK310846.1 AK313119.1 AK316195.1 AK316198.1 AK316362.1 
    AY191309.1 AY191310.1 AY225407.1 AY365426.1 AY786585.1 AY786586.1 AY786587.1 AY787587.1 
    BC003069.2 BC008611.1 BC019236.2 D14350.1 D14351.1 D14354.1 D16841.1 D16842.1 
    D16843.1 D26550.1 D32129.1 D32130.1 D32131.1 D38525.1 D50068.1 D83515.1 
    D83516.1 DQ327718.1 DQ327719.1 DQ327720.1 DQ327721.1 DQ327722.1 DQ336693.1 DQ336694.1 
    DQ336695.1 FM202434.1 JQ313909.1 L06425.1 L06440.1 L18898.1 L19403.1 L76936.1 
    M11887.1 M12377.1 M12758.1 M23739.1 M24042.1 M24095.1 M27537.1 M27538.1 
    M27539.1 M27971.1 M32321.1 M64740.1 M84375.1 M84377.1 M84378.1 M84379.1 
    M86404.1 M94880.1 M98453.1 S42062.1 U03697.1 U03754.1 U03907.1 U07161.1 
    U07234.1 U09740.1 U17569.1 U17570.1 U17571.1 U18930.1 U24261.1 U25971.1 
    U32184.1 U36914.1 U41057.1 U43334.1 U43335.1 U43336.1 U45480.1 U50574.1 
    U52429.1 U56825.1 U83415.1 U83416.1 X02457.1 X13111.1 X13112.1 X51745.1 
    X57954.1 X60108.1 X60764.1 X61700.1 X61701.1 X61702.1 X61703.1 X61704.1 
    X61705.1 X61711.1 X61712.1 X91399.1 X94566.1 X94567.1 X94568.1 X94569.1 
    X94570.1 X94571.1 X94572.1 X94573.1 X95409.1 X95561.1 X96638.1 X96724.1 
    X97120.1 X97802.1 Y08275.1 Y11441.1 Y13028.1 Y13267.1 Y17224.1 Z23071.1 
    Z27120.1 Z46633.1 

    Selected DOTS entries (see all 168):

    DT.91783875  DT.95333141  DT.100046040  DT.100733427  DT.91783982  DT.95090280  DT.95378900  DT.92045303 
    DT.100733391  DT.100733373  DT.100733433  DT.100733374  DT.95376642  DT.100855576  DT.91783956  DT.100799521 
    DT.95137848  DT.91911697  DT.91680045  DT.86995001  DT.95376858  DT.100645439  DT.100733406  DT.95376774 

    Selected AceView cDNA sequences (see all 65):

    CR620975 CR610110 CR608593 CR601516 CR600696 CR590761 CR591238 CR598869 
    CR611213 CR609975 CR596197 CR590089 CR605752 CR621304 CR605841 CR625317 
    CR612012 CR604944 CR593473 CR619724 CR605111 CR622028 CR625955 CR600122 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HLA-A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGCTCAGA
    HLA-A Expression
    About this image


    HLA-A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone marrow-derived mesenchymal stem cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical tissue-derived cells (CNTO2476)
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Interscapular Brown Adipose Depot
             Adipose-derived mesenchymal stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    HLA-A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181244
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-A: 
              Innate & Adaptive Immune Responses in human mouse rat
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-A
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-A
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-A
    QuantiFast Probe-based Assays in human, mouse, rat HLA-A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-A gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Q101 , 5 histocompatibility 2, Q region locus 101, 5 80.85(n)1
    75.24(a)1
      17 (18.68 cM)5
    150071  NM_010391.41  NP_034521.11 
     354700895 
    chicken
    (Gallus gallus)
    Aves LOC1008587331 class I histocompatibility antigen, F10 alpha chain-like 54.53(n)
    43.69(a)
      100858733  XM_003643799.2  XP_003643847.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5630361 uncharacterized LOC563036 46.79(n)
    34.34(a)
      563036  XM_001919256.4  XP_001919291.4 


    ENSEMBL Gene Tree for HLA-A (if available)
    TreeFam Gene Tree for HLA-A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HLA-A gene
    HLA-F2  MR12  FCGRT2  HFE2  HLA-B2  HLA-E2  HLA-C2  HLA-G2  
    AZGP12  
    Selected SIMAP similar genes for HLA-A using alignment to 5215 protein entries:     1A01_HUMAN (see all proteins) (see all similar genes):
    MHC class II HLA-DRB1 Exon-2    HLA-A*0201V3    HLA-ABC    DRB1*13PL    HLA-DR beta    HLA-DR-beta
    HLA-DR3    HLA-DRB1*1327    HLA-DRB1*1605    HLA-DRB14    MHC class II HLA DRB1-0305    MHC class II HLA-DRB1*1315
    DRB1*08    DRB1*1116    DRB1*LY10    HLA-DRB1*08    HLA-DRB1*1302Var    HLA-DRB1*1324

    Find genes that share paralogs with HLA-A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    1A01_HUMAN, P30443: The following alleles of A-1 are known: A*01:01, A*01:02, A*01:03, A*01:06 and A*01:07. The sequence
    shown is that of A*01:01
    1A02_HUMAN, P01892: The following alleles of A-2 are known: A*02:01, A*02:02, A*02:03, A*02:04, A*02:05, A*02:06
    (A2.4A), A*02:07, A*02:08, A*02:09, A*02:10, A*02:11 (A2.5), A*02:12, A*02:13 (A*02SLU), A*02:16, A*02:17,
    A*02:18 (A2K), A*02:19, A*02:20, A*02:21, A*02:31, A*02:34 (A*AAT), A*02:35, A*02:36 and A*02:37. The sequence
    shown is that of A*02:01
    1A03_HUMAN, P04439: The following alleles of A-3 are known: A*03:01 (A-3.1), A*03:02, A*03:04, A*03:05 and A*03:06. The
    sequence shown is that of A*03:01
    1A11_HUMAN, P13746: The following alleles of A-11 are known: A*11:01 (A-11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05
    and A*11:07. The sequence shown is that of A*11:01
    1A23_HUMAN, P30447: The following alleles of A-23 are known: A*23:01, A*23:02, A*23:03, A*23:04 and A*23:05. The
    sequence shown is that of A*23:01
    1A24_HUMAN, P05534: The following alleles of A-24 are known: A*2401, A*24:02, A*24:03, A*24:06, A*24:08 (A9HH), A*24:10
    (A*24JV), A*24:13 (A*24YM), A*24:14 (A*24SA) and A*24:29. Allele A*24:02 is represented in all major racial
    groups. Allele A*24:06 and allele A*24:13 are found in the Australian Aboriginal population. Allele A*24:14 is
    found in individuals of South American descent. The sequence shown is that of A*24:02
    1A25_HUMAN, P18462: The following alleles of A-25 are known: A*25:01 A*25:02 and A*25:03. The sequence shown is that of
    A*25:01
    1A26_HUMAN, P30450: The following alleles of A-26 are known: A*26:01, A*26:02, A*26:03, A*26:04 (A-10SA), A*26:05,
    A*26:07, A*26:08, A*26:12 and A*26:15. The sequence shown is that of A*26:01
    1A29_HUMAN, P30512: The following alleles of A-29 are known: A*29:01 (A29.1), A*29:02 (A29.2), A*29:03 and A*29:04. The
    sequence shown is that of A*29:01
    1A30_HUMAN, P16188: The following alleles of A-30 are known: A*30:01 (A30.3), A*30:02, A*30:03, A*30:04 (A30W7),
    A*30:06, A*30:07 and A*30:08. The sequence shown is that of A*30:01
    1A31_HUMAN, P16189: The following alleles of A-31 are known: A*31:01, A*31:02, A*31:03, A*31:04, A*31:05 (A3101v1) and
    A*31:06. The sequence shown is that of A*31:01. Allele A*31:01 is associated with carbamazepine-induced
    hypersensitivity reactions among subjects of Northern European ancestry [MIM:608579]
    1A32_HUMAN, P10314: The following alleles of A-32 are known: A*32:01, A*32:02, A*32:03, A*32:04, A*32:05 and A*32:06.
    The sequence shown is that of A*32:01
    1A33_HUMAN, P16190: The following alleles of A-33 are known: A*33:01 (Aw-33.1), A*3302 and A*33:03. The sequence shown
    is that of A*33:01
    1A34_HUMAN, P30453: The following alleles of A-34 are known: A*34:01 (Aw-34.1) and A*34:02 (Aw-34.2). The sequence shown
    is that of A*34:01
    1A36_HUMAN, P30455: The following alleles of A-36 are known: A*36:01 and A*36:02. The sequence shown is that of A*36:01
    1A43_HUMAN, P30456: The only allele of A-43 known is A*43:01 which is shown here
    1A66_HUMAN, P30457: The following alleles of A-66 are known: A*66:01 and A*66:02 (Aw67). The sequence shown is that of
    A*66:01
    1A68_HUMAN, P01891: The following alleles of A-68 are known: A*68:01 (Aw68.1), A*68:02, A*68:03. A*68:04, A*68:05,
    A*68:06, A*68:07, A*68:08, A*68:09, A*68:10, A*68:16 and A*68:17. The sequence shown is that of A*68:01
    1A69_HUMAN, P10316: The only allele of A-69 known is A*69:01 which is shown here
    1A74_HUMAN, P30459: The following alleles of A-74 are known: A*74:01 A*74:02, A*74:03, A*74:04 and A*74:05. The sequence
    shown is that of A*74:01
    1A80_HUMAN, Q09160: The only allele of A-80 known is A*80:01 which is shown here


    Selected SNPs for HLA-A (see all 1370)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31290161,2
    Chistocompatibility11(+) GTGGAA/C/GGGGCT 15 E D mis1 syn10--------
    rs31290171,2
    Chistocompatibility11(-) CGCACA/C/G/
            
    TGCCA
    21 Q P R L K T M mis11NA 4114
    rs415412211,2
    C,Fhistocompatibility129910033(+) GCACAG/AGAGCA 6 -- us2k12Minor allele frequency- A:0.09NA EA 240
    rs27351141,2
    C,Fhistocompatibility129910034(-) CTGCTC/TCTGTG 6 -- us2k19Minor allele frequency- T:0.42NA WA EA 372
    rs412725471,2
    C,Fhistocompatibility129910057(+) GAAGTC/ACCAGG 6 -- us2k11Minor allele frequency- A:0.03NA 120
    rs31326881,2
    C,A,Hhistocompatibility129910083(-) GAGACC/TCTGAG 6 -- us2k16Minor allele frequency- T:0.00NA WA CSA 9
    rs92601161,2
    C,Fhistocompatibility129910105(+) GCGGTG/ATATGG 6 -- us2k16Minor allele frequency- A:0.05NA CSA EA 249
    rs119642541,2
    C,Hhistocompatibility129910122(+) GAGTCC/ACAGCC 6 -- us2k14Minor allele frequency- A:0.08WA NA EA 360
    rs27351131,2
    C,Fhistocompatibility129910167(+) GTTGGG/CAGAGG 6 -- us2k12Minor allele frequency- C:0.06WA NA 238
    rs92601181,2
    C,Fhistocompatibility129910176(+) ACCTAT/CGTAGG 6 -- us2k17Minor allele frequency- C:0.33NA WA CSA EA 364

    HapMap Linkage Disequilibrium report for HLA-A (29909037 - 29913661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-A (see all 47):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1086e199CNV Deletion23128226
    esv2659548CNV Deletion23128226
    esv2731778CNV Deletion23290073
    esv2641340CNV Deletion19546169
    esv2677901CNV Deletion23128226
    esv2670487CNV Deletion23128226
    dgv1039e201CNV Deletion23290073
    nsv820564CNV Deletion20802225
    esv2665698CNV Deletion23128226
    dgv1087e199CNV Deletion23128226

    Human Gene Mutation Database (HGMD): HLA-A
    Locus Specific Mutation Databases (LSDB): HLA-A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-A
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 142800   
    OMIM disorders: 608579  
    Selected diseases for HLA-A (see all 23):    
    About MalaCards
    hypersensitivity syndrome, carbamazepine-induced    birdshot chorioretinopathy    postherpetic neuralgia    smallpox
    pleomorphic malignant fibrous histiocytoma    chromoblastomycosis    x-linked myopathy with excessive autophagy    small fiber neuropathy
    neonatal hemochromatosis    pars planitis    delusional disorder    pityriasis rosea
    pure red-cell aplasia    chronic pyelonephritis    dengue shock syndrome    cytomegalovirus retinitis
    nasopharynx carcinoma    connective tissue disease    histoplasmosis    alveolar echinococcosis

    20 diseases from the University of Copenhagen DISEASES database for HLA-A:
    Melanoma     Hypersensitivity reaction type II disease     Leukemia     Influenza
    Psoriasis     Hemochromatosis     Hepatitis B     Arthritis
    Vaccinia     Diabetes mellitus     Hepatitis     Human immunodeficiency virus infectious disease
    Nasopharynx carcinoma     Stevens-Johnson syndrome     Carcinoma     Ankylosing spondylitis
    Connective tissue disease     Uveitis     Multiple sclerosis     Kidney disease

    Find genes that share disorders with HLA-A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HLA-A gene (see all 80)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bare lymphocyte syndrome 47.3 1 8229525 (1)
    genetic susceptibility 45.8 4 19392852 (2), 15603871 (1), 16635082 (1)
    hepatitis autoimmune 43.9 1 2175292 (1)
    tumors 40.6 53 17538388 (2), 9286277 (2), 18422748 (2), 1849792 (1) (see all 43)
    melanoma 39.7 26 7686817 (3), 11948496 (2), 10233766 (2), 10432284 (1) (see all 17)
    cholangitis primary sclerosing 36.1 1 7875491 (1)
    immunodeficiency 34.2 12 15989466 (2), 12552458 (1), 18971252 (1), 17202219 (1) (see all 11)
    autoimmune diseases 34 2 16417220 (1), 9293772 (1)
    hepatitis c 28.3 6 14722889 (1), 1711000 (1), 19604246 (1), 7693568 (1) (see all 6)
    nasopharyngeal carcinoma 26.4 4 12929995 (1), 11291059 (1), 1978435 (1), 15726104 (1)

    Genetic Association Database (GAD): HLA-A
    Human Genome Epidemiology (HuGE) Navigator: HLA-A (2863 documents)

    Export disorders for HLA-A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for HLA-A gene, integrated from 10 sources (see all 1577):
    (articles sorted by number of sources associating them with HLA-A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of HLA-A and HLA-B genes in genetic susceptibility to esophageal carcinoma in Chaoshan Han Chinese. (PubMed id 19392852)1, 4, 9 Hu S.P....Cai K.L. (Dis. Esophagus 2010)
    2. [Human leucocyte antigen gene (HLA-A, HLA-B, HLA-DRB1) frequencies in deceased organ donors]. (PubMed id 18320121)1, 4, 9 RodrA-guez L.M....GarcA-a L.F. (Biomedica 2007)
    3. A NOTCH4 association with multiple sclerosis is secondary to HLA-DR*1501. (PubMed id 14651518)1, 4, 9 Duvefelt K....Hillert J. (Tissue Antigens 2004)
    4. Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. (PubMed id 18987644)1, 4, 9 Eike M.C....Lie B.A. (Genes Immun. 2009)
    5. Polymorphism of HLA-A and HLA-B in pre-eclampsia. (PubMed id 19727231)1, 4, 9 Zhang Z....Zhang L.L. (Beijing Da Xue Xue Bao 2009)
    6. [Haplotipic associations of the two most common HLA-B*27 alleles in the Croatian population]. (PubMed id 19024262)1, 4, 9 GrubiA8 Z....Kerhin-BrkljaciA8 V. (Reumatizam 2008)
    7. MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059. (PubMed id 20097244)1, 4, 9 Tian W.... Li L.X. (Hum. Immunol. 2010)
    8. Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia. (PubMed id 20169624)1, 4, 9 Kuniholm M.H....Carrington M. (Hepatology 2010)
    9. High-resolution HLA matching in double-umbilical-cord-blood reduced-intensity transplantation in adults. (PubMed id 19159415)1, 4, 9 Delaney M....Ballen K.K. (Transfusion 2009)
    10. KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma. (PubMed id 19934297)1, 4, 9 Venstrom J.M....Hsu K.C. (Clin. Cancer Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3105 HGNC: 4931 AceView: HLA-A Ensembl:ENSG00000206503 euGenes: HUgn3105
    ECgene: HLA-A Kegg: 3105 H-InvDB: HLA-A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HLA-A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HLA-A gene:
    Search GeneIP for patents involving HLA-A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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