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HKR1 Gene

protein-coding   GIFtS: 50
GCID: GC19P037803

HKR1, GLI-Kruppel Zinc Finger Family Member

(Previous name: GLI-Kruppel family member HKR1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HKR1, GLI-Kruppel Zinc Finger Family Member1 2     ZNF8752 3
GLI-Kruppel Family Member HKR11 2     Krueppel-Related Zinc Finger Protein 12
Oncogene HKR11 2     Protein HKR13
Zinc Finger Protein 8752 3     

External Ids:    HGNC: 49281   Entrez Gene: 2844592   Ensembl: ENSG000001816667   OMIM: 1652505   UniProtKB: P100723   

Export aliases for HKR1 gene to outside databases

Previous GC identifers: GC19U990048 GC19P042484 GC19P042517 GC19P037825 GC19P034275


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HKR1 Gene:
HKR1 (HKR1, GLI-Kruppel zinc finger family member) is a protein-coding gene. Diseases associated with HKR1 include lung cancer. An important paralog of this gene is ZNF432.

UniProtKB/Swiss-Prot: HKR1_HUMAN, P10072
Function: May be involved in transcriptional regulation

Gene Wiki entry for HKR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HKR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHKR1 promoter sequence
   Search Chromatin IP Primers for HKR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HKR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

HKR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HKR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P037803:  view genomic region     (about GC identifiers)

Start:
37,803,739 bp from pter      End:
37,860,267 bp from pter
Size:
56,529 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HKR1_HUMAN, P10072 (See protein sequence)
Recommended Name: Krueppel-related zinc finger protein 1  
Size: 659 amino acids; 75128 Da
Sequence caution: Sequence=BAA86058.1; Type=Erroneous initiation;
Secondary accessions: A8MRS7 Q6PJD0 Q9BSW9 Q9UM09
Alternative splicing: 2 isoforms:  P10072-1   P10072-2   

Explore the universe of human proteins at neXtProt for HKR1: NX_P10072

Explore proteomics data for HKR1 at MOPED


See HKR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_861451.1  
ENSEMBL proteins: 
 ENSP00000466467   ENSP00000437774   ENSP00000465297   ENSP00000468528   ENSP00000465884  
 ENSP00000465899   ENSP00000466360   ENSP00000467822   ENSP00000468176   ENSP00000375994  
 ENSP00000466533   ENSP00000467562   ENSP00000315505   ENSP00000466472   ENSP00000466498  
 ENSP00000438261   ENSP00000466856   ENSP00000468572   ENSP00000465862  
Reactome Protein details: P10072

HKR1 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for HKR1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P10072

ProtoNet protein and cluster: P10072

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: HKR1_HUMAN, P10072
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 13 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


HKR1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HKR1_HUMAN, P10072
Function: May be involved in transcriptional regulation

     Genatlas biochemistry entry for HKR1:
GLI-Kruppel family member HKR1

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding ----
GO:0046872metal ion binding IEA--
     
HKR1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HKR1
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HKR1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HKR1

miRNA
Products:
    
miRTarBase miRNAs that target HKR1:
hsa-mir-125b-5p (MIRT045911)

Block miRNA regulation of human, mouse, rat HKR1 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate HKR1:
hsa-miR-377
SwitchGear 3'UTR luciferase reporter plasmidHKR1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for HKR1
Predesigned siRNA for gene silencing in human, mouse, rat HKR1

Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HKR1

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HKR1_HUMAN, P10072: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
golgi apparatus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

HKR1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HKR1 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for HKR1
    Generic Transcription Pathway



HKR1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HKR1
Interactions:

    Search GeneGlobe Interaction Network for HKR1

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated NAS2850480
GO:0007275multicellular organismal development NAS2850480

HKR1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HKR1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HKR1 gene: 
NM_181786.2  

Unigene Cluster for HKR1:

HKR1, GLI-Kruppel zinc finger family member
Hs.657027  [show with all ESTs]
Unigene Representative Sequence: AK128116
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
ENST00000591471 ENST00000587570 ENST00000589218 ENST00000592362 ENST00000544914(uc002ofy.3)
ENST00000587829 ENST00000589188 ENST00000591485 ENST00000589801 ENST00000592768
ENST00000591417 ENST00000585623 ENST00000592168 ENST00000591391 ENST00000392153(uc002ofz.3 uc002oga.3 uc010xto.2)
ENST00000590386 ENST00000587437 ENST00000589392
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HKR1 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate HKR1:
hsa-miR-377
SwitchGear 3'UTR luciferase reporter plasmidHKR1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HKR1
Predesigned siRNA for gene silencing in human, mouse, rat HKR1
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GenScript: all cDNA clones in your preferred vector: HKR1 (NM_181786)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HKR1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HKR1
Primer
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OriGene qPCR primer pairs and template standards for HKR1
OriGene qSTAR qPCR primer pairs in human, mouse for HKR1
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HKR1
  QuantiTect SYBR Green Assays in human, mouse, rat HKR1
  QuantiFast Probe-based Assays in human, mouse, rat HKR1

Additional mRNA sequence: 

AK056243.1 AK128116.1 XR_109514.1 XR_133182.1 XR_158933.1 XR_158934.1 XR_159317.1 XR_159318.1 
XR_172286.1 XR_172287.1 XR_172288.1 

6 DOTS entries:

DT.95242513  DT.100781822  DT.312808  DT.97807297  DT.100729343  DT.121485614 

Selected AceView cDNA sequences (see all 200):

BG413401 AI279056 BU625422 BE463501 AI081665 BX344036 AI364896 AW179090 
CD671430 BQ001113 BU191956 AW513018 BE328065 AA340342 CK299769 AI741226 
BX107668 BM450709 AI702840 AA932812 AW250798 BU622938 AI420536 AI828662 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for HKR1 (see all 13)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
SP1:                                      -     -     -           -     -           -     -           -     -     -                                             
SP2:                                            -     -     -     -                 -     -           -     -     -                                             
SP3:                                      -     -     -     -     -                 -     -           -     -     -                                             
SP4:                                      -     -     -     -     -                 -     -           -     -     -                                             
SP5:                                      -     -     -     -     -                 -     -           -     -                                                   

ExUns: 11h · 11i · 11j · 11k
SP1:                        
SP2:                        
SP3:                        
SP4:                        
SP5:                        


ECgene alternative splicing isoforms for HKR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HKR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HKR1 Expression
About this image

HKR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HKR1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.657027
    Custom PCR Arrays for HKR1
Primer
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QuantiFast Probe-based Assays in human, mouse, rat HKR1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HKR1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for HKR1 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia HKR11 HKR1, GLI-Kruppel zinc finger family member 86.87(n)
83.73(a)
  484542  XM_003638865.2  XP_003638913.2 


ENSEMBL Gene Tree for HKR1 (if available)
TreeFam Gene Tree for HKR1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HKR1 gene
ZNF4322  ZNF5892  PRDM92  ZNF1332  ENSG000002565662  ZNF3432  ZNF1692  
Selected SIMAP similar genes for HKR1 using alignment to 16 protein entries:     HKR1_HUMAN (see all proteins) (see all similar genes):
FAM3A    UBIAD1    CTSS    CRCP    DAPK2    ERBB2
ATL2    TNFRSF17    FAM210A    NEK4    TSEN2    kr-znf3
TMEM14B    PRMD9    KDM5B    UTY    LINC00596    C4orf22

HKR1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for HKR1
PGOHUM00000242618


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HKR1 (see all 752)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1848190121,2
--37823712(+) CACTGC/TGTTTA 1 -- us2k10--------
rs15305001,2
C,F,O,H--37823811(+) TTTACG/AAGGGT 1 -- us2k130Minor allele frequency- A:0.09NS EA NA WA CSA 2500
rs1896754341,2
--37823824(+) CTCAGA/GTGAGA 1 -- us2k10--------
rs72576721,2
C,F,A,H--37823859(+) GCACTG/CAGTAA 1 -- us2k1 tfbs314Minor allele frequency- C:0.36NS EA NA WA CSA 783
rs72574951,2
C,F,A,H--37823876(+) CCTTTG/CATTTA 1 -- us2k114Minor allele frequency- C:0.31NS EA NA WA CSA 743
rs1512882651,2
--37823877(+) CTTTCA/GTTTAA 1 -- us2k10--------
rs730254671,2
C--37823942(+) TGTAGA/CGTTTC 1 -- us2k12Minor allele frequency- C:0.04NA 122
rs1164013141,2
F--37824087(+) CACCTA/TCATCT 1 -- us2k11Minor allele frequency- T:0.08WA 118
rs1818100041,2
--37824232(+) CTGTGA/GTTCCC 1 -- us2k10--------
rs1406119901,2
--37824289(+) TGGCCA/GGGTCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for HKR1 (37803739 - 37860267 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HKR1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv9718CNV Loss18304495
dgv1081e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HKR1
DNA2.0 Custom Variant and Variant Library Synthesis for HKR1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 165250    OMIM disorders: --

1 disease for HKR1:    
About MalaCards
lung cancer


HKR1 for disorders           About GeneDecksing


Export disorders for HKR1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HKR1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with HKR1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The Kruppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs. (PubMed id 9813242)1, 2, 3 Oguri T.... Watanabe H. (Gene 1998)
  2. The GLI-Kruppel family of human genes. (PubMed id 2850480)1, 2, 3 Ruppert J.M.... Vogelstein B. (Mol. Cell. Biol. 1988)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization. (PubMed id 8812445)1 Matsumoto N....Niikawa N. (Genomics 1996)
  9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284459 HGNC: 4928 AceView: HKR1 Ensembl:ENSG00000181666 euGenes: HUgn284459
ECgene: HKR1 H-InvDB: HKR1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HKR1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HKR1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HKR1 gene:
Search GeneIP for patents involving HKR1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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