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Aliases for HKR1 Gene

Aliases for HKR1 Gene

  • HKR1, GLI-Kruppel Zinc Finger Family Member 2 3
  • GLI-Kruppel Family Member HKR1 2 3
  • Zinc Finger Protein 875 3 4
  • Oncogene HKR1 2 3
  • ZNF875 3 4
  • Protein HKR1 4

External Ids for HKR1 Gene

Previous GeneCards Identifiers for HKR1 Gene

  • GC19U990048
  • GC19P042484
  • GC19P042517
  • GC19P037825
  • GC19P034275
  • GC19P037803

Summaries for HKR1 Gene

GeneCards Summary for HKR1 Gene

HKR1 (HKR1, GLI-Kruppel Zinc Finger Family Member) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF169.

UniProtKB/Swiss-Prot for HKR1 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for HKR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HKR1 Gene

Genomics for HKR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HKR1 Gene

Chromosome:
19
Start:
37,312,837 bp from pter
End:
37,369,365 bp from pter
Size:
56,529 bases
Orientation:
Plus strand

Genomic View for HKR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HKR1 Gene

No data available for Regulatory Elements for HKR1 Gene

Proteins for HKR1 Gene

  • Protein details for HKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10072-HKR1_HUMAN
    Recommended name:
    Krueppel-related zinc finger protein 1
    Protein Accession:
    P10072
    Secondary Accessions:
    • A8MRS7
    • Q6PJD0
    • Q9BSW9
    • Q9UM09

    Protein attributes for HKR1 Gene

    Size:
    659 amino acids
    Molecular mass:
    75128 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86058.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HKR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HKR1 Gene

Proteomics data for HKR1 Gene at MOPED

Post-translational modifications for HKR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for HKR1 Gene

Domains & Families for HKR1 Gene

Gene Families for HKR1 Gene

Protein Domains for HKR1 Gene

Suggested Antigen Peptide Sequences for HKR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10072

UniProtKB/Swiss-Prot:

HKR1_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HKR1: view

Function for HKR1 Gene

Molecular function for HKR1 Gene

GENATLAS Biochemistry:
GLI-Kruppel family member HKR1
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HKR1: view

Phenotypes for HKR1 Gene

genes like me logo Genes that share phenotypes with HKR1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HKR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HKR1 Gene

Localization for HKR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HKR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HKR1 Gene COMPARTMENTS Subcellular localization image for HKR1 gene
Compartment Confidence
nucleus 3
golgi apparatus 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HKR1: view

Pathways & Interactions for HKR1 Gene

SuperPathways for HKR1 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with HKR1: view

Pathways by source for HKR1 Gene

2 Reactome pathways for HKR1 Gene

Interacting Proteins for HKR1 Gene

Gene Ontology (GO) - Biological Process for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 2850480
GO:0007275 multicellular organismal development NAS 2850480
genes like me logo Genes that share ontologies with HKR1: view

No data available for SIGNOR curated interactions for HKR1 Gene

Drugs & Compounds for HKR1 Gene

No Compound Related Data Available

Transcripts for HKR1 Gene

Unigene Clusters for HKR1 Gene

HKR1, GLI-Kruppel zinc finger family member:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HKR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HKR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - -
SP13: - - -

ExUns: 11h · 11i · 11j · 11k
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for HKR1 Gene

GeneLoc Exon Structure for
HKR1
ECgene alternative splicing isoforms for
HKR1

Expression for HKR1 Gene

mRNA expression in normal human tissues for HKR1 Gene

Protein differential expression in normal tissues from HIPED for HKR1 Gene

This gene is overexpressed in Islet of Langerhans (34.7) and Breast (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HKR1 Gene



SOURCE GeneReport for Unigene cluster for HKR1 Gene Hs.657027

genes like me logo Genes that share expression patterns with HKR1: view

Protein tissue co-expression partners for HKR1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HKR1 Gene

Orthologs for HKR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HKR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HKR1 35
  • 82.94 (n)
  • 75.73 (a)
dog
(Canis familiaris)
Mammalia HKR1 35
  • 86.87 (n)
  • 83.73 (a)
HKR1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HKR1 35
  • 98.73 (n)
  • 98.09 (a)
HKR1 36
  • 96 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDA9 38
Species with no ortholog for HKR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HKR1 Gene

ENSEMBL:
Gene Tree for HKR1 (if available)
TreeFam:
Gene Tree for HKR1 (if available)

Paralogs for HKR1 Gene

Paralogs for HKR1 Gene

Pseudogenes.org Pseudogenes for HKR1 Gene

genes like me logo Genes that share paralogs with HKR1: view

Variants for HKR1 Gene

Sequence variations from dbSNP and Humsavar for HKR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs256741 -- 37,364,937(-) cagaa(G/T)aatgg downstream-variant-500B
rs256742 -- 37,364,891(-) gatcg(C/T)gccac downstream-variant-500B
rs256743 -- 37,364,874(-) ccagc(C/G)tgggt downstream-variant-500B
rs256744 -- 37,364,586(-) ctgga(C/T)ctcac downstream-variant-500B
rs502546 -- 37,361,788(-) aggcg(C/T)ccaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HKR1 Gene

Variant ID Type Subtype PubMed ID
dgv1081e1 CNV Complex 17122850
nsv9718 CNV Loss 18304495

Variation tolerance for HKR1 Gene

Residual Variation Intolerance Score: 91.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HKR1 Gene

HapMap Linkage Disequilibrium report
HKR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HKR1 Gene

Disorders for HKR1 Gene

Relevant External Links for HKR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HKR1
genes like me logo Genes that share disorders with HKR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HKR1 Gene

Publications for HKR1 Gene

  1. The Kruppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs. (PMID: 9813242) Oguri T. … Watanabe H. (Gene 1998) 2 67
  2. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert J.M. … Vogelstein B. (Mol. Cell. Biol. 1988) 2 67
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for HKR1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HKR1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HKR1
  • Block miRNA regulation of HKR1 using miScript Target Protectors

Sources for HKR1 Gene

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