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Aliases for HKR1 Gene

Aliases for HKR1 Gene

  • HKR1, GLI-Kruppel Zinc Finger Family Member 2 3
  • GLI-Kruppel Family Member HKR1 2 3
  • Zinc Finger Protein 875 3 4
  • Oncogene HKR1 2 3
  • ZNF875 3 4
  • Krueppel-Related Zinc Finger Protein 1 3
  • Protein HKR1 4

External Ids for HKR1 Gene

Summaries for HKR1 Gene

GeneCards Summary for HKR1 Gene

HKR1 (HKR1, GLI-Kruppel Zinc Finger Family Member) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF169.

UniProtKB/Swiss-Prot for HKR1 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for HKR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HKR1 Gene

Genomics for HKR1 Gene

Genomic Location for HKR1 Gene

Start:
37,312,837 bp from pter
End:
37,369,365 bp from pter
Size:
56,529 bases
Orientation:
Plus strand

Genomic View for HKR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HKR1 Gene

No data available for Regulatory Elements for HKR1 Gene

Proteins for HKR1 Gene

  • Protein details for HKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10072-HKR1_HUMAN
    Recommended name:
    Krueppel-related zinc finger protein 1
    Protein Accession:
    P10072
    Secondary Accessions:
    • A8MRS7
    • Q6PJD0
    • Q9BSW9
    • Q9UM09

    Protein attributes for HKR1 Gene

    Size:
    659 amino acids
    Molecular mass:
    75128 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86058.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HKR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HKR1 Gene

Proteomics data for HKR1 Gene at MOPED

Post-translational modifications for HKR1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HKR1 Gene

Domains for HKR1 Gene

Gene Families for HKR1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for HKR1 Gene

UniProtKB/Swiss-Prot:

HKR1_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • P10072
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P10072
Similarity:
  • Contains 13 C2H2-type zinc fingers.:
    • P10072
genes like me logo Genes that share domains with HKR1: view

Function for HKR1 Gene

Molecular function for HKR1 Gene

GENATLAS Biochemistry: GLI-Kruppel family member HKR1
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HKR1: view

miRNA for HKR1 Gene

miRTarBase miRNAs that target HKR1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HKR1 Gene

Localization for HKR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HKR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HKR1 Gene COMPARTMENTS Subcellular localization image for HKR1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HKR1: view

Pathways for HKR1 Gene

SuperPathways for HKR1 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with HKR1: view

Pathways by source for HKR1 Gene

2 Reactome pathways for HKR1 Gene

Interacting Proteins for HKR1 Gene

Gene Ontology (GO) - Biological Process for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 2850480
GO:0007275 multicellular organismal development NAS 2850480
genes like me logo Genes that share ontologies with HKR1: view

Transcripts for HKR1 Gene

Unigene Clusters for HKR1 Gene

HKR1, GLI-Kruppel zinc finger family member:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HKR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - -
SP13: - - -

ExUns: 11h · 11i · 11j · 11k
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for HKR1 Gene

GeneLoc Exon Structure for
HKR1
ECgene alternative splicing isoforms for
HKR1

Expression for HKR1 Gene

mRNA expression in normal human tissues for HKR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HKR1 Gene

SOURCE GeneReport for Unigene cluster for HKR1 Gene Hs.657027

genes like me logo Genes that share expressions with HKR1: view

Orthologs for HKR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HKR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HKR1 36
  • 98.73 (n)
  • 98.09 (a)
HKR1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HKR1 36
  • 82.94 (n)
  • 75.73 (a)
dog
(Canis familiaris)
Mammalia HKR1 36
  • 86.87 (n)
  • 83.73 (a)
HKR1 37
  • 76 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDA9 39
Species with no ortholog for HKR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HKR1 Gene

ENSEMBL:
Gene Tree for HKR1 (if available)
TreeFam:
Gene Tree for HKR1 (if available)

Paralogs for HKR1 Gene

Paralogs for HKR1 Gene

Pseudogenes.org Pseudogenes for HKR1 Gene

genes like me logo Genes that share paralogs with HKR1: view

Variants for HKR1 Gene

Sequence variations from dbSNP and Humsavar for HKR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs256741 -- 37,364,937(-) cagaa(G/T)aatgg downstream-variant-500B
rs256742 -- 37,364,891(-) gatcg(C/T)gccac downstream-variant-500B
rs256743 -- 37,364,874(-) ccagc(C/G)tgggt downstream-variant-500B
rs256744 -- 37,364,586(-) ctgga(C/T)ctcac downstream-variant-500B
rs502546 -- 37,361,788(-) aggcg(C/T)ccaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HKR1 Gene

Variant ID Type Subtype PubMed ID
dgv1081e1 CNV Complex 17122850
nsv9718 CNV Loss 18304495

Relevant External Links for HKR1 Gene

HapMap Linkage Disequilibrium report
HKR1

Disorders for HKR1 Gene

No disorders were found for HKR1 Gene.

No data available for UniProtKB/Swiss-Prot for HKR1 Gene

Publications for HKR1 Gene

  1. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert J.M. … Vogelstein B. (Mol. Cell. Biol. 1988) 2 3 4
  2. The Kruppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs. (PMID: 9813242) Oguri T. … Watanabe H. (Gene 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for HKR1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HKR1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HKR1
  • Block miRNA regulation of HKR1 using miScript Target Protectors

Sources for HKR1 Gene

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