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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HKR1 Gene

protein-coding   GIFtS: 50
GCID: GC19P037803

HKR1, GLI-Kruppel Zinc Finger Family Member

(Previous name: GLI-Kruppel family member HKR1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
HKR1, GLI-Kruppel Zinc Finger Family Member1 2     ZNF8752 3
GLI-Kruppel Family Member HKR11 2     Krueppel-Related Zinc Finger Protein 12
Oncogene HKR11 2     Protein HKR13
Zinc Finger Protein 8752 3     

External Ids:    HGNC: 49281   Entrez Gene: 2844592   Ensembl: ENSG000001816667   OMIM: 1652505   UniProtKB: P100723   

Export aliases for HKR1 gene to outside databases

Previous GC identifers: GC19U990048 GC19P042484 GC19P042517 GC19P037825 GC19P034275


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HKR1 Gene: 
HKR1 (HKR1, GLI-Kruppel zinc finger family member) is a protein-coding gene. Diseases associated with HKR1 include lung cancer, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF589.

UniProtKB/Swiss-Prot: HKR1_HUMAN, P10072
Function: May be involved in transcriptional regulation

Gene Wiki entry for HKR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HKR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHKR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HKR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HKR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

HKR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HKR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P037803:  view genomic region     (about GC identifiers)

Start:
37,803,739 bp from pter      End:
37,860,267 bp from pter
Size:
56,529 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HKR1_HUMAN, P10072 (See protein sequence)
Recommended Name: Krueppel-related zinc finger protein 1  
Size: 659 amino acids; 75128 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA86058.1; Type=Erroneous initiation;
Secondary accessions: A8MRS7 Q6PJD0 Q9BSW9 Q9UM09
Alternative splicing: 2 isoforms:  P10072-1   P10072-2   

Explore the universe of human proteins at neXtProt for HKR1: NX_P10072

Explore proteomics data for HKR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10072

  • HKR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HKR1 Protein Expression
    REFSEQ proteins: NP_861451.1  
    ENSEMBL proteins: 
     ENSP00000466467   ENSP00000437774   ENSP00000465297   ENSP00000468528   ENSP00000465884  
     ENSP00000465899   ENSP00000466360   ENSP00000467822   ENSP00000468176   ENSP00000375994  
     ENSP00000466533   ENSP00000467562   ENSP00000315505   ENSP00000466472   ENSP00000466498  
     ENSP00000438261   ENSP00000466856   ENSP00000468572   ENSP00000465862  
    Reactome Protein details: P10072
    Human Recombinant Protein Products for HKR1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HKR1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--

    HKR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P10072

    ProtoNet protein and cluster: P10072

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: HKR1_HUMAN, P10072
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    HKR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HKR1_HUMAN, P10072
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for HKR1:
    GLI-Kruppel family member HKR1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding NAS--
    GO:0046872metal ion binding ----
         
    HKR1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HKR1 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HKR1:
    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidHKR1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HKR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for HKR1
        Generic Transcription Pathway
    Gene Expression



    HKR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HKR1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS2850480
    GO:0007275multicellular organismal development NAS2850480

    HKR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HKR1

    Search CenterWatch for drugs/clinical trials and news about HKR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HKR1 gene: 
    NM_181786.2  

    Unigene Clusters for HKR1:

    HKR1, GLI-Kruppel zinc finger family member
    Hs.657027  [show with all ESTs], Hs.729090  [show with all ESTs]
    Unigene Representative Sequences: AK128116, NM_181786
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000591471 ENST00000587570 ENST00000589218 ENST00000592362 ENST00000544914(uc002ofy.3)
    ENST00000587829 ENST00000589188 ENST00000591485 ENST00000589801 ENST00000592768
    ENST00000591417 ENST00000585623 ENST00000592168 ENST00000591391 ENST00000392153(uc002ofz.3 uc002oga.3 uc010xto.2)
    ENST00000590386 ENST00000587437 ENST00000589392
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HKR1:
    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidHKR1 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HKR1

    Additional mRNA sequence: 

    AB013897.1 AK223616.1 AK299969.1 AK301601.1 AK307852.1 BC004513.2 BC010024.2 BC017256.2 
    BC053845.1 

    18 DOTS entries:

    DT.312808  DT.121485592  DT.95242513  DT.100781822  DT.97793419  DT.97826550  DT.100781818  DT.100781823 
    DT.95283524  DT.97807297  DT.100729343  DT.100781816  DT.121485614  DT.91763330  DT.95280537  DT.91882143 
    DT.95102871  DT.97824031 

    24/200 AceView cDNA sequences (see all 200):

    AI081665 BM694993 AI420536 AW513538 AA932812 AA450118 AI702840 BX107668 
    R88735 AI279056 BQ001113 BE463501 AW179090 AW513018 BU625422 AA007370 
    AI369326 AA340342 AW594170 BE328065 AI741226 BU729520 BX344036 BC053845 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for HKR1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
    SP1:                                      -     -     -           -     -           -     -           -     -     -                                             
    SP2:                                            -     -     -     -                 -     -           -     -     -                                             
    SP3:                                      -     -     -     -     -                 -     -           -     -     -                                             
    SP4:                                      -     -     -     -     -                 -     -           -     -     -                                             
    SP5:                                      -     -     -     -     -                 -     -           -     -                                                   

    ExUns: 11h · 11i · 11j · 11k
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for HKR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HKR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HKR1 Expression
    About this image


    See HKR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HKR1

    SOURCE GeneReport for Unigene clusters: Hs.657027 Hs.729090
        SABiosciences Custom PCR Arrays for HKR1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for HKR1 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia HKR11 HKR1, GLI-Kruppel zinc finger family member 86.87(n)
    83.73(a)
      484542  XM_003638865.1  XP_003638913.1 


    ENSEMBL Gene Tree for HKR1 (if available)
    TreeFam Gene Tree for HKR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HKR1 gene
    ZNF5892  ZNF1332  ENSG000002565662  ZNF3432  ZNF1692  
    18/602 SIMAP similar genes for HKR1 using alignment to 16 protein entries:     HKR1_HUMAN (see all proteins) (see all similar genes):
    FAM3A    UBIAD1    CRCP    DAPK2    ERBB2    ATL2
    TNFRSF17    FAM210A    NEK4    TSEN2    kr-znf3    TMEM14B
    PRMD9    KDM5B    UTY    LINC00596    C4orf22    LYRM4

    HKR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HKR1
    PGOHUM00000242618


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/752 SNPs in HKR1 are shown (see all 752)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848190121,2
    --37823712(+) CACTGC/TGTTTA 1 -- us2k10--------
    rs15305001,2
    C,F,O,H--37823811(+) TTTACG/AAGGGT 1 -- us2k130Minor allele frequency- A:0.09NS EA NA WA CSA 2500
    rs1896754341,2
    --37823824(+) CTCAGA/GTGAGA 1 -- us2k10--------
    rs72576721,2
    C,F,A,H--37823859(+) GCACTG/CAGTAA 1 -- us2k1 tfbs314Minor allele frequency- C:0.36NS EA NA WA CSA 783
    rs72574951,2
    C,F,A,H--37823876(+) CCTTTG/CATTTA 1 -- us2k114Minor allele frequency- C:0.31NS EA NA WA CSA 743
    rs1512882651,2
    --37823877(+) CTTTCA/GTTTAA 1 -- us2k10--------
    rs730254671,2
    C--37823942(+) TGTAGA/CGTTTC 1 -- us2k12Minor allele frequency- C:0.04NA 122
    rs1164013141,2
    F--37824087(+) CACCTA/TCATCT 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1818100041,2
    --37824232(+) CTGTGA/GTTCCC 1 -- us2k10--------
    rs1406119901,2
    --37824289(+) TGGCCA/GGGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HKR1 (37803739 - 37860267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HKR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv9718CNV Loss18304495
    dgv1081e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165250    OMIM disorders: --

    2 diseases for HKR1:    About MalaCards
    lung cancer    


    HKR1 for disorders           About GeneDecksing


    Export disorders for HKR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HKR1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HKR1)
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    world of online information

    1. The Kruppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs. (PubMed id 9813242)1, 2, 3 Oguri T.... Watanabe H. (1998)
    2. The GLI-Kruppel family of human genes. (PubMed id 2850480)1, 2, 3 Ruppert J.M.... Vogelstein B. (1988)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization. (PubMed id 8812445)1 Matsumoto N....Niikawa N. (1996)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284459 HGNC: 4928 AceView: HKR1 Ensembl:ENSG00000181666 euGenes: HUgn284459
    ECgene: HKR1 H-InvDB: HKR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HKR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HKR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HKR1 gene:
    Search GeneIP for patents involving HKR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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