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Aliases for HKDC1 Gene

Aliases for HKDC1 Gene

  • Hexokinase Domain Containing 1 2 3
  • EC 2.7.1.1 4 63
  • Hexokinase Domain-Containing Protein 1 4
  • EC 2.7.1 63

External Ids for HKDC1 Gene

Previous GeneCards Identifiers for HKDC1 Gene

  • GC10U900457
  • GC10P070651
  • GC10P070980
  • GC10P064980

Summaries for HKDC1 Gene

GeneCards Summary for HKDC1 Gene

HKDC1 (Hexokinase Domain Containing 1) is a Protein Coding gene. Diseases associated with HKDC1 include amebiasis. Among its related pathways are Metabolism and HIF-1 signaling pathway. GO annotations related to this gene include glucokinase activity and mannokinase activity. An important paralog of this gene is HK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HKDC1 Gene

Genomics for HKDC1 Gene

Regulatory Elements for HKDC1 Gene

Genomic Location for HKDC1 Gene

Start:
69,220,303 bp from pter
End:
69,267,559 bp from pter
Size:
47,257 bases
Orientation:
Plus strand

Genomic View for HKDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HKDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HKDC1 Gene

Proteins for HKDC1 Gene

  • Protein details for HKDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TB90-HKDC1_HUMAN
    Recommended name:
    Putative hexokinase HKDC1
    Protein Accession:
    Q2TB90
    Secondary Accessions:
    • B5MDN9
    • Q2TB91
    • Q5VTC7
    • Q7Z373
    • Q8WU37
    • Q96EH2
    • Q9H5Y9

    Protein attributes for HKDC1 Gene

    Size:
    917 amino acids
    Molecular mass:
    102545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21278.1; Type=Frameshift; Positions=457; Evidence={ECO:0000305}; Sequence=BAB15478.1; Type=Frameshift; Positions=345; Evidence={ECO:0000305};

    Alternative splice isoforms for HKDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HKDC1 Gene

Proteomics data for HKDC1 Gene at MOPED

Post-translational modifications for HKDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HKDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for HKDC1 Gene

Protein Domains for HKDC1 Gene

Suggested Antigen Peptide Sequences for HKDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TB90

UniProtKB/Swiss-Prot:

HKDC1_HUMAN :
  • Q2TB90
Domain:
  • Contains 2 hexokinase domains.
Family:
  • Belongs to the hexokinase family.
genes like me logo Genes that share domains with HKDC1: view

No data available for Gene Families for HKDC1 Gene

Function for HKDC1 Gene

Molecular function for HKDC1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + D-hexose = ADP + D-hexose 6-phosphate

Enzyme Numbers (IUBMB) for HKDC1 Gene

Gene Ontology (GO) - Molecular Function for HKDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004340 glucokinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008865 fructokinase activity IBA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor --
GO:0019158 mannokinase activity IBA --
genes like me logo Genes that share ontologies with HKDC1: view

Phenotypes for HKDC1 Gene

GenomeRNAi human phenotypes for HKDC1:
genes like me logo Genes that share phenotypes with HKDC1: view

miRNA for HKDC1 Gene

miRTarBase miRNAs that target HKDC1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HKDC1 Gene

Localization for HKDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HKDC1 Gene COMPARTMENTS Subcellular localization image for HKDC1 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HKDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with HKDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HKDC1 Gene

Pathways for HKDC1 Gene

genes like me logo Genes that share pathways with HKDC1: view

UniProtKB/Swiss-Prot Q2TB90-HKDC1_HUMAN

  • Pathway: Carbohydrate metabolism; hexose metabolism

Interacting Proteins for HKDC1 Gene

Gene Ontology (GO) - Biological Process for HKDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis IBA --
GO:0005975 carbohydrate metabolic process --
GO:0006096 glycolytic process IBA --
GO:0019318 hexose metabolic process IEA --
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with HKDC1: view

Transcripts for HKDC1 Gene

Unigene Clusters for HKDC1 Gene

Hexokinase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HKDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for HKDC1 Gene

GeneLoc Exon Structure for
HKDC1
ECgene alternative splicing isoforms for
HKDC1

Expression for HKDC1 Gene

mRNA expression in normal human tissues for HKDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HKDC1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (15.6), Kidney - Cortex (9.4), and Colon - Transverse (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HKDC1 Gene

SOURCE GeneReport for Unigene cluster for HKDC1 Gene Hs.522988

genes like me logo Genes that share expressions with HKDC1: view

No data available for mRNA Expression by UniProt/SwissProt for HKDC1 Gene

Orthologs for HKDC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HKDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HKDC1 35
  • 97.48 (n)
  • 97.44 (a)
HKDC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HKDC1 35
  • 88.95 (n)
  • 93.02 (a)
HKDC1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HKDC1 35
  • 89.35 (n)
  • 93.57 (a)
HKDC1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hkdc1 35
  • 86.76 (n)
  • 91.47 (a)
Hkdc1 16
Hkdc1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HKDC1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HKDC1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves HKDC1 35
  • 75.37 (n)
  • 84.43 (a)
HKDC1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HKDC1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hkdc1 35
  • 71.99 (n)
  • 80.66 (a)
zebrafish
(Danio rerio)
Actinopterygii hkdc1 35
  • 69.94 (n)
  • 75.25 (a)
hkdc1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hex-A 36
  • 38 (a)
ManyToMany
Hex-C 36
  • 40 (a)
ManyToMany
Hex-t2 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F14B4.2 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMI2 36
  • 30 (a)
ManyToMany
GLK1 36
  • 30 (a)
ManyToMany
HXK1 36
  • 31 (a)
ManyToMany
HXK2 36
  • 30 (a)
ManyToMany
HXK2 38
rice
(Oryza sativa)
Liliopsida Os05g0187100 35
  • 50.97 (n)
  • 44.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11095 36
  • 47 (a)
OneToMany
Species with no ortholog for HKDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HKDC1 Gene

ENSEMBL:
Gene Tree for HKDC1 (if available)
TreeFam:
Gene Tree for HKDC1 (if available)

Paralogs for HKDC1 Gene

Paralogs for HKDC1 Gene

Selected SIMAP similar genes for HKDC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HKDC1: view

Variants for HKDC1 Gene

Sequence variations from dbSNP and Humsavar for HKDC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2611 -- 69,267,475(-) CAACA(C/G)CTGCA utr-variant-3-prime
rs906219 - 69,266,754(-) TCCTA(G/T)TTCTC missense, reference
rs925024 -- 69,255,241(-) TTTGA(C/T)GTCTC intron-variant
rs1021964 -- 69,247,095(+) TACGA(C/T)AGGGT intron-variant
rs1027793 -- 69,254,657(-) CGAAA(A/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HKDC1 Gene

Variant ID Type Subtype PubMed ID
nsv508589 CNV Loss 20534489
esv2462035 CNV Deletion 19546169
esv2407805 CNV Deletion 18987734
esv3686 CNV Deletion 18987735
esv2738095 CNV Deletion 23290073
esv6582 CNV Loss 19470904
nsv895695 CNV Gain 21882294

Relevant External Links for HKDC1 Gene

HapMap Linkage Disequilibrium report
HKDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HKDC1 Gene

Disorders for HKDC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HKDC1 Gene including...

Search for HKDC1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HKDC1 Gene

Relevant External Links for HKDC1

Genetic Association Database (GAD)
HKDC1
Human Genome Epidemiology (HuGE) Navigator
HKDC1
genes like me logo Genes that share disorders with HKDC1: view

No data available for UniProtKB/Swiss-Prot for HKDC1 Gene

Publications for HKDC1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. (PMID: 20732627) Neale B.M. … Biederman J. (J Am Acad Child Adolesc Psychiatry 2010) 3 48
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for HKDC1 Gene

Sources for HKDC1 Gene

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