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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HK3 Gene

protein-coding   GIFtS: 66
GCID: GC05M176240

Hexokinase 3 (White Cell)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hexokinase 3 (White Cell)1 2     HXK32
Hexokinase Type III2 3     ATP:D-Hexose 6-Phosphotransferase2
HK III2 3     hexokinase-32
EC 2.7.1.13 8     EC 2.7.18
HKIII2     

External Ids:    HGNC: 49251   Entrez Gene: 31012   Ensembl: ENSG000001608837   OMIM: 1425705   UniProtKB: P527903   

Export aliases for HK3 gene to outside databases

Previous GC identifers: GC05M176681 GC05M177150 GC05M176243 GC05M176288 GC05M171230


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HK3 Gene:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism
pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by
its product glucose-6-phosphate. (provided by RefSeq, Apr 2009)

GeneCards Summary for HK3 Gene: 
HK3 (hexokinase 3 (white cell)) is a protein-coding gene. Diseases associated with HK3 include schizophrenia, and alcoholism, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Galactose metabolism. GO annotations related to this gene include glucokinase activity and enzyme binding. An important paralog of this gene is HKDC1.

Gene Wiki entry for HK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HK3 gene promoter:
         GR   Pbx1a   MIF-1   POU2F1   POU2F1a   POU2F1b   PPAR-gamma2   GR-alpha   POU2F1c   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

HK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HK3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176240:  view genomic region     (about GC identifiers)

Start:
176,307,870 bp from pter      End:
176,326,333 bp from pter
Size:
18,464 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790 (See protein sequence)
Recommended Name: Hexokinase-3  
Size: 923 amino acids; 99025 Da
Subunit: Monomer (By similarity)
Miscellaneous: In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I,
II, III and IV (glucokinase)
1 PDB 3D structure from and Proteopedia for HK3:
3HM8 (3D)    
Secondary accessions: Q8N1E7

Explore the universe of human proteins at neXtProt for HK3: NX_P52790

Explore proteomics data for HK3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52790

  • 4/16 DME Specific Peptides for HK3 (P52790) (see all 16)
     GQDVVQL  EWGAFGD  GLIVGTG  AMVTAVA 

    HK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HK3 Protein Expression
    REFSEQ proteins: NP_002106.2  
    ENSEMBL proteins: 
     ENSP00000292432   ENSP00000424632   ENSP00000422169   ENSP00000427000  
    Reactome Protein details: P52790
    Human Recombinant Protein Products for HK3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for HK3 
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    Novus Biologicals HK3 Proteins
    Novus Biologicals HK3 Lysates
    Sino Biological Recombinant Protein for HK3
    Sino Biological Cell Lysate for HK3 
    ProSpec Recombinant Protein for HK3
    Cloud-Clone Corp. Proteins for HK3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane NAS--
    GO:0043234protein complex IEA--

    HK3 for ontologies           About GeneDecksing



    HK3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HK3
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    LSBio Antibodies in human, mouse, rat for HK3 

    Assay Products for HK3: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HK3 
    Cloud-Clone Corp. CLIAs for HK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR019807 Hexokinase_CS
     IPR001312 Hexokinase
     IPR022672 Hexokinase_N
     IPR022673 Hexokinase_C

    Graphical View of Domain Structure for InterPro Entry P52790

    ProtoNet protein and cluster: P52790

    1 Blocks protein domain: IPB001312 Hexokinase

    UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790
    Domain: The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The
    catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus
    Similarity: Belongs to the hexokinase family


    HK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXK3_HUMAN, P52790
    Catalytic activity: ATP + D-hexose = ADP + D-hexose 6-phosphate
    Enzyme regulation: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P

         Genatlas biochemistry entry for HK3:
    hexokinase 3,108kDa,expressed in liver,lung,spleen,glycolysis,gluconeogenesis,energy pathways

         Enzyme Numbers (IUBMB): EC 2.7.1.11 2 EC 2.7.12

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004340glucokinase activity IBA--
    GO:0004396hexokinase activity NAS--
    GO:0005515protein binding ----
    GO:0005524ATP binding NAS--
    GO:0008865fructokinase activity IBA--
         
    HK3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HK3:
     Decreased TP53 protein express  Increased cell death HMECs cel  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HK3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HK3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HK3:
    hsa-miR-942 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidHK3 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HK3 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)0.60
    Conversion of glucose to acetyl CoA and entry into the TCA cycle0.46
    Glycolysis and Gluconeogenesis0.60
    Glycolysis / Gluconeogenesis0.46
    glycolysis0.50
    2Galactose metabolism
    Galactose metabolism0.46
    Glycogen metabolism0.40
    Galactose metabolism0.46
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Hexose transport0.87
    5SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HK3
        Glycogen metabolism
    Glycolysis and gluconeogenesis (short map)
    Galactose metabolism


    3 GeneGo (Thomson Reuters) Pathways for HK3
        Galactose metabolism
    Glycogen metabolism
    Glycolysis and gluconeogenesis (short map)

    3 BioSystems Pathways for HK3
        Glycolysis and Gluconeogenesis
    glycolysis
    Conversion of glucose to acetyl CoA and entry into the TCA cycle


    5/6        Reactome Pathways for HK3 (see all 6)
        Metabolism of carbohydrates
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Hexose transport
    Metabolism


    5/12         Kegg Pathways  (Kegg details for HK3) (see all 12):
        Glycolysis / Gluconeogenesis
    Fructose and mannose metabolism
    Galactose metabolism
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism

    UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790
    Pathway: Carbohydrate metabolism; hexose metabolism


    HK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for HK3 (P527903 ENSP000002924324) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGFBP4P226923, ENSP000002695934I2D: score=3 STRING: ENSP00000269593
    GRNP287993, ENSP000000538674I2D: score=4 STRING: ENSP00000053867
    PTGDSP412223, ENSP000003606874I2D: score=3 STRING: ENSP00000360687
    HPGDSO607603, ENSP000002952564I2D: score=2 STRING: ENSP00000295256
    LEPP411593, ENSP000003126524I2D: score=3 STRING: ENSP00000312652
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001678cellular glucose homeostasis IBA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006096glycolysis NAS--
    GO:0008645hexose transport TAS--
    GO:0015758glucose transport TAS--

    HK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HK3 (HXK3)

    10/18 HMDB Compounds for HK3 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Alpha-D-GlucoseHexopyranose (see all 11)492-62-6--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    Beta-D-Glucoseb-D-Glucopyranose (see all 8)492-61-5--
    Beta-D-Glucose 6-phosphatebeta-D-glucose 6-(dihydrogen phosphate) (see all 3)----
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    D-MannoseDL-mannose (see all 13)3458-28-4--
    Glucosamine2-Amino-2-deoxy-D-glucopyranose (see all 10)3416-24-8--
    Glucosamine 6-phosphate2-Amino-2-deoxy-D-glucose 6-phosphate (see all 14)3616-42-0--

    1 Novoseek inferred chemical compound relationship for HK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 40.2 2 9468341 (1), 12455831 (1)

    Search CenterWatch for drugs/clinical trials and news about HK3 / HXK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HK3 gene: 
    NM_002115.2  

    Unigene Cluster for HK3:

    Hexokinase 3 (white cell)
    Hs.411695  [show with all ESTs]
    Unigene Representative Sequence: AB208951
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506834 ENST00000292432(uc003mez.3 uc003mfa.3) ENST00000514666
    ENST00000514058 ENST00000509717 ENST00000504910
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HK3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HK3:
    hsa-miR-942 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidHK3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HK3

    Additional mRNA sequence: 

    AB208951.1 BC028129.1 U51333.1 

    3 DOTS entries:

    DT.441134  DT.100718626  DT.92037217 

    24/67 AceView cDNA sequences (see all 67):

    CD368330 CB529448 CD368453 CD368053 BX095227 CA309463 BC028129 CB528781 
    CD370640 CD366037 CB529264 NM_002115 CD367171 U51333 CB528863 AI089249 
    CD368609 BI908489 CD557470 AW467633 AL597571 CA308619 BQ010955 CD614071 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HK3 expression in normal human tissues (normalized intensities)      HK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGACCCCT
    HK3 Expression
    About this image


    HK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Conventional Dendritic Cells I Spleen
             Bone Marrow CD33+ Cells   
             c-kit+ gr1+ mac1- myeloblasts   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             bone marrow   
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   
     
     Lateral Plate Mesoderm (Muscoskeletal System)
             skeleton/axial skeleton   

    See HK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HK3

    SOURCE GeneReport for Unigene cluster: Hs.411695
        SABiosciences Expression via Pathway-Focused PCR Array including HK3: 
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HK3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hk31 , 5 hexokinase 31, 5 84.08(n)1
    85.67(a)1
      13 (29.80 cM)5
    2120321  NM_001206390.11  NP_001193319.11 
     550059855 
    chicken
    (Gallus gallus)
    Aves LOC7684211 hexokinase-3-like 63.07(n)
    56.07(a)
      768421  XM_001231328.2  XP_001231329.2 
    lizard
    (Anolis carolinensis)
    Reptilia HK36
    Uncharacterized protein
    28(a)
    possible ortholog
    GL343526.1(1010-12327)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hex-A3 hexokinase 47(a)
    (best of 4)
      1 8E10   --
    worm
    (Caenorhabditis elegans)
    Secernentea F14B4.23 hexokinase 46(a)
    (best of 3)
      I(9279949-9281838)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HXK1(YFR053C)4 Hexokinase isoenzyme 1, a cytosolic protein that catalyzes more   --   6(255049-253592) 850614  NP_116711.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04468001 hypothetical protein 51.47(n)
    41.86(a)
      4343113  NM_001066073.1  NP_001059538.1 


    ENSEMBL Gene Tree for HK3 (if available)
    TreeFam Gene Tree for HK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HK3 gene
    HKDC12  HK22  HK12  GCK2  
    5 SIMAP similar genes for HK3 using alignment to 5 protein entries:     HXK3_HUMAN (see all proteins):
    HK2    DKFZp686M1669    HKDC1    GCK    HK1

    HK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/595 SNPs in HK3 are shown (see all 595)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361874
    A breast cancer sample4--see VAR_0361872 A V mis40--------
    VAR_0361864
    A colorectal cancer sample4--see VAR_0361862 R W mis40--------
    rs2007509381,2
    --176308404(+) ACACCC/TGCCCC 2 A syn10--------
    rs2016953751,2
    C--176308519(+) CCTGCC/TGCAGG 2 Q R mis10--------
    rs2007842431,2
    --176308538(+) GTCACC/TGGGGG 1 -- spa10--------
    rs3768107351,2
    C--176308563(+) AGCACA/GGGGAG 1 -- int10--------
    rs1999335941,2
    C--176308575(+) TGGGTC/TGTGAC 1 -- int10--------
    rs1815487461,2
    C--176308647(+) GTGGAC/TAGAAA 1 -- int10--------
    rs1416535941,2
    C,F--176308655(+) AAAGAC/ACCCCT 1 -- int11Minor allele frequency- A:0.03EU 1270
    rs1461737581,2
    C,F--176308657(+) AGACCC/TCCTGA 1 -- int11Minor allele frequency- T:0.03EU 1277

    HapMap Linkage Disequilibrium report for HK3 (176307870 - 176326333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270879CNV Insertion20981092
    esv273198CNV Insertion20981092
    dgv732n27CNV Loss19166990
    nsv883155CNV Loss21882294
    dgv6377n71CNV Loss21882294
    dgv362n21CNV Loss19592680
    dgv6376n71CNV Loss21882294
    dgv6378n71CNV Loss21882294
    nsv462562CNV Loss19166990
    nsv519416CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142570    OMIM disorders: --

    7 diseases for HK3:    About MalaCards
    schizophrenia    alcoholism    lung cancer    diabetes mellitus
    thyroiditis    adenocarcinoma    breast cancer


    HK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HK3
    Human Genome Epidemiology (HuGE) Navigator: HK3 (56 documents)

    Export disorders for HK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HK3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with HK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. (PubMed id 8812439)1, 2, 3, 9 Furuta H.... Bell G.I. (1996)
    2. Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. (PubMed id 8717435)1, 2, 9 Palma F.... Stocchi V. (1996)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Genome-wide association studies identify loci associa ted with age at menarche and age at natural menopause. (PubMed id 19448621)1, 4 He C....Chasman D.I. (2009)
    5. Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules. (PubMed id 17868400)1, 9 Hooft L....van Diest P.J. (2008)
    6. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PubMed id 9468341)1, 9 Lowes W....Agius L. (1998)
    7. Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization. (PubMed id 8941369)1, 9 Colosimo A....Dallapiccola B. (1996)
    8. PU.1 is linking the glycolytic enzyme HK3 in neutrophi l differentiation and survival of APL cells. (PubMed id 22498738)1 Federzoni E.A....Tschan M.P. (2012)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Regulation and cytoprotective role of hexokinase III. (PubMed id 21072205)1 Wyatt E....Ardehali H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3101 HGNC: 4925 AceView: HK3 Ensembl:ENSG00000160883 euGenes: HUgn3101
    ECgene: HK3 Kegg: 3101 H-InvDB: HK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HK3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hexokinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HK3 gene:
    Search GeneIP for patents involving HK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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