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Aliases for HK3 Gene

Aliases for HK3 Gene

  • Hexokinase 3 (White Cell) 2 3
  • Hexokinase Type III 3 4
  • EC 2.7.1.1 4 64
  • HK III 3 4
  • ATP:D-Hexose 6-Phosphotransferase 3
  • Hexokinase-3 3
  • EC 2.7.1 64
  • HKIII 3
  • HXK3 3

External Ids for HK3 Gene

Summaries for HK3 Gene

Entrez Gene Summary for HK3 Gene

  • Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

GeneCards Summary for HK3 Gene

HK3 (Hexokinase 3 (White Cell)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include enzyme binding and glucokinase activity. An important paralog of this gene is HK2.

Gene Wiki entry for HK3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HK3 Gene

Genomics for HK3 Gene

Genomic Location for HK3 Gene

Start:
176,880,869 bp from pter
End:
176,899,332 bp from pter
Size:
18,464 bases
Orientation:
Minus strand

Genomic View for HK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HK3 Gene

Regulatory Elements for HK3 Gene

Proteins for HK3 Gene

  • Protein details for HK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52790-HXK3_HUMAN
    Recommended name:
    Hexokinase-3
    Protein Accession:
    P52790
    Secondary Accessions:
    • Q8N1E7

    Protein attributes for HK3 Gene

    Size:
    923 amino acids
    Molecular mass:
    99025 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase)

    Three dimensional structures from OCA and Proteopedia for HK3 Gene

neXtProt entry for HK3 Gene

Proteomics data for HK3 Gene at MOPED

Post-translational modifications for HK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HK3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HK3 Gene

Protein Domains for HK3 Gene

UniProtKB/Swiss-Prot:

HXK3_HUMAN
Domain:
  • The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus:
    • P52790
  • Contains 2 hexokinase domains.:
    • P52790
Family:
  • Belongs to the hexokinase family.:
    • P52790
genes like me logo Genes that share domains with HK3: view

No data available for Gene Families for HK3 Gene

Function for HK3 Gene

Molecular function for HK3 Gene

GENATLAS Biochemistry: hexokinase 3,108kDa,expressed in liver,lung,spleen,glycolysis,gluconeogenesis,energy pathways
UniProtKB/Swiss-Prot CatalyticActivity: ATP + D-hexose = ADP + D-hexose 6-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P

Enzyme Numbers (IUBMB) for HK3 Gene

Gene Ontology (GO) - Molecular Function for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004340 glucokinase activity IBA --
GO:0004396 hexokinase activity IDA 8717435
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008865 fructokinase activity IBA --
genes like me logo Genes that share ontologies with HK3: view
genes like me logo Genes that share phenotypes with HK3: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HK3 Gene

Localization for HK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HK3 Gene COMPARTMENTS Subcellular localization image for HK3 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with HK3: view

Pathways for HK3 Gene

genes like me logo Genes that share pathways with HK3: view

UniProtKB/Swiss-Prot P52790-HXK3_HUMAN

  • Pathway: Carbohydrate metabolism; hexose metabolism

Gene Ontology (GO) - Biological Process for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis IBA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006096 glycolytic process --
GO:0008645 hexose transport TAS --
genes like me logo Genes that share ontologies with HK3: view

Compounds for HK3 Gene

(18) HMDB Compounds for HK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Alpha-D-Glucose
  • Hexopyranose
492-62-6
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Not Available
Beta-D-Glucose
  • b-D-Glucopyranose
492-61-5

(1) Novoseek inferred chemical compound relationships for HK3 Gene

Compound -log(P) Hits PubMed IDs
glucose 40.2 2
genes like me logo Genes that share compounds with HK3: view

Transcripts for HK3 Gene

Unigene Clusters for HK3 Gene

Hexokinase 3 (white cell):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HK3 Gene

No ASD Table

Relevant External Links for HK3 Gene

GeneLoc Exon Structure for
HK3
ECgene alternative splicing isoforms for
HK3

Expression for HK3 Gene

mRNA expression in normal human tissues for HK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HK3 Gene

This gene is overexpressed in Whole Blood (38.4) and Spleen (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HK3 Gene

SOURCE GeneReport for Unigene cluster for HK3 Gene Hs.411695

genes like me logo Genes that share expressions with HK3: view

Orthologs for HK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HK3 36
  • 99.24 (n)
  • 99.24 (a)
HK3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HK3 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HK3 36
  • 88.01 (n)
  • 90.14 (a)
HK3 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hk3 36
  • 84.08 (n)
  • 85.67 (a)
Hk3 16
Hk3 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HK3 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HK3 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hk3 36
  • 83.8 (n)
  • 85.54 (a)
chicken
(Gallus gallus)
Aves HK3 36
  • 63.07 (n)
  • 56.07 (a)
HK3 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HK3 37
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hex-A 37
  • 35 (a)
ManyToMany
Hex-C 37
  • 37 (a)
ManyToMany
Hex-t2 37
  • 33 (a)
ManyToMany
Hex-t2 38
  • 42 (a)
Hex-t1 38
  • 31 (a)
Hex-A 38
  • 47 (a)
Hex-C 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea F14B4.2 37
  • 40 (a)
OneToMany
Y77E11A.1 38
  • 36 (a)
H25P06.1 38
  • 41 (a)
F14B4.2 38
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMI2 37
  • 29 (a)
ManyToMany
GLK1 37
  • 29 (a)
ManyToMany
HXK1 37
  • 28 (a)
ManyToMany
HXK1 39
HXK2 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11095 37
  • 40 (a)
OneToMany
Species with no ortholog for HK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HK3 Gene

ENSEMBL:
Gene Tree for HK3 (if available)
TreeFam:
Gene Tree for HK3 (if available)

Paralogs for HK3 Gene

Paralogs for HK3 Gene

Selected SIMAP similar genes for HK3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HK3: view

Variants for HK3 Gene

Sequence variations from dbSNP and Humsavar for HK3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs479270 -- 176,894,573(-) GTGCC(C/T)GACCC intron-variant
rs493578 -- 176,898,176(-) GAGCT(A/G)TCAGT intron-variant
rs494450 -- 176,882,048(-) TGCAT(C/T)AACAT reference, synonymous-codon
rs522150 -- 176,890,742(-) AGCTT(C/T)TCTAC intron-variant
rs539822 -- 176,883,163(-) AGAAC(C/T)GACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HK3 Gene

Variant ID Type Subtype PubMed ID
dgv6376n71 CNV Loss 21882294
dgv6377n71 CNV Loss 21882294
dgv6378n71 CNV Loss 21882294
dgv732n27 CNV Loss 19166990
nsv883155 CNV Loss 21882294
nsv462562 CNV Loss 19166990
dgv362n21 CNV Loss 19592680
nsv519416 CNV Gain 19592680
esv270879 CNV Insertion 20981092
esv273198 CNV Insertion 20981092

Relevant External Links for HK3 Gene

HapMap Linkage Disequilibrium report
HK3

Disorders for HK3 Gene

Relevant External Links for HK3

Genetic Association Database (GAD)
HK3
Human Genome Epidemiology (HuGE) Navigator
HK3
genes like me logo Genes that share disorders with HK3: view

No data available for UniProtKB/Swiss-Prot for HK3 Gene

Publications for HK3 Gene

  1. Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. (PMID: 8812439) Furuta H. … Bell G.I. (Genomics 1996) 2 3 4 23
  2. Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. (PMID: 8717435) Palma F. … Stocchi V. (Mol. Cell. Biochem. 1996) 3 4 23
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization. (PMID: 8941369) Colosimo A. … Dallapiccola B. (Cytogenet. Cell Genet. 1996) 3 23
  5. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. (PMID: 19448621) He C. … Chasman D.I. (Nat. Genet. 2009) 3 49

Products for HK3 Gene

  • Addgene plasmids for HK3

Sources for HK3 Gene

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