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HK3 Gene

protein-coding   GIFtS: 66
GCID: GC05M176240

Hexokinase 3 (White Cell)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hexokinase 3 (White Cell)1 2     HXK32
Hexokinase Type III2 3     ATP:D-Hexose 6-Phosphotransferase2
HK III2 3     hexokinase-32
EC 2.7.1.13 8     EC 2.7.18
HKIII2     

External Ids:    HGNC: 49251   Entrez Gene: 31012   Ensembl: ENSG000001608837   OMIM: 1425705   UniProtKB: P527903   

Export aliases for HK3 gene to outside databases

Previous GC identifers: GC05M176681 GC05M177150 GC05M176243 GC05M176288 GC05M171230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HK3 Gene:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism
pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by
its product glucose-6-phosphate. (provided by RefSeq, Apr 2009)

GeneCards Summary for HK3 Gene:
HK3 (hexokinase 3 (white cell)) is a protein-coding gene. GO annotations related to this gene include glucokinase activity and enzyme binding. An important paralog of this gene is HKDC1.

Gene Wiki entry for HK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the HK3 gene promoter:
         GR   Pbx1a   MIF-1   POU2F1   POU2F1a   POU2F1b   PPAR-gamma2   GR-alpha   POU2F1c   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHK3 promoter sequence
   Search Chromatin IP Primers for HK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

HK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HK3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176240:  view genomic region     (about GC identifiers)

Start:
176,307,870 bp from pter      End:
176,326,333 bp from pter
Size:
18,464 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790 (See protein sequence)
Recommended Name: Hexokinase-3  
Size: 923 amino acids; 99025 Da
Subunit: Monomer (By similarity)
Miscellaneous: In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I,
II, III and IV (glucokinase)
1 PDB 3D structure from and Proteopedia for HK3:
3HM8 (3D)    
Secondary accessions: Q8N1E7

Explore the universe of human proteins at neXtProt for HK3: NX_P52790

Explore proteomics data for HK3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HK3 (P52790) (see all 16)
     GQDVVQL  EWGAFGD  GLIVGTG  AMVTAVA 


    See HK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002106.2  
    ENSEMBL proteins: 
     ENSP00000292432   ENSP00000424632   ENSP00000422169   ENSP00000427000  
    Reactome Protein details: P52790

    HK3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for HK3
    OriGene Protein Over-expression Lysate for HK3
    OriGene MassSpec for HK3
    OriGene Custom Protein Services for HK3
    GenScript Custom Purified and Recombinant Proteins Services for HK3
    Novus Biologicals HK3 Proteins
    Novus Biologicals HK3 Lysates
    Sino Biological Recombinant Protein for HK3
    Sino Biological Cell Lysate for HK3
    ProSpec Recombinant Protein for HK3
    Cloud-Clone Corp. Proteins for HK3

     
    Search eBioscience for Proteins for HK3 

     
    antibodies-online proteins for HK3 (18 products) 

     
    antibodies-online peptides for HK3

    HK3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HK3
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    OriGene Antibodies for HK3
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    Novus Biologicals HK3 Antibodies
    Abcam antibodies for HK3
    Cloud-Clone Corp. Antibodies for HK3
    ThermoFisher Antibodies for HK3
    LSBio Antibodies in human, mouse, rat for HK3
    antibodies-online antibodies for HK3 (88 products) 

    HK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HK3
    Cloud-Clone Corp. CLIAs for HK3
    Search eBioscience for ELISAs for HK3 
    antibodies-online kits for HK3 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019807 Hexokinase_CS
     IPR001312 Hexokinase
     IPR022672 Hexokinase_N
     IPR022673 Hexokinase_C

    Graphical View of Domain Structure for InterPro Entry P52790

    ProtoNet protein and cluster: P52790

    1 Blocks protein domain: IPB001312 Hexokinase

    UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790
    Domain: The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The
    catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus
    Similarity: Belongs to the hexokinase family
    Similarity: Contains 2 hexokinase type-1 domains
    Similarity: Contains 2 hexokinase type-2 domains


    Find genes that share domains with HK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXK3_HUMAN, P52790
    Catalytic activity: ATP + D-hexose = ADP + D-hexose 6-phosphate
    Enzyme regulation: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P

         Genatlas biochemistry entry for HK3:
    hexokinase 3,108kDa,expressed in liver,lung,spleen,glycolysis,gluconeogenesis,energy pathways

         Enzyme Numbers (IUBMB): EC 2.7.1.11 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004340glucokinase activity IBA--
    GO:0004396hexokinase activity IDA8717435
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008865fructokinase activity IBA--
         
    Find genes that share ontologies with HK3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HK3:
     Decreased TP53 protein express  Increased cell death HMECs cel  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HK3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HK3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HK3:
    hsa-miR-942 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidHK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HK3
    Predesigned siRNA for gene silencing in human, mouse, rat HK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HK3

    Clone
    Products:
         
    OriGene clones in human, mouse for HK3 (see all 7)
    OriGene ORF clones in mouse, rat for HK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HK3 (NM_002115)
    Sino Biological Human cDNA Clone for HK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HK3
    Addgene plasmids for HK3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for HK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----
    GO:0043234protein complex IEA--

    Find genes that share ontologies with HK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HK3 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    glycolysis0.00
    2Galactose metabolism
    Galactose metabolism0.44
    Butirosin and neomycin biosynthesis0.00
    Galactose metabolism0.44
    3Glucuronidation
    Starch and sucrose metabolism0.41
    Glycogen metabolism0.00
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Hexose transport0.87


    Find genes that share SuperPaths with HK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for HK3
        Galactose metabolism
    Glycogen metabolism
    Glycolysis and gluconeogenesis (short map)

    3 BioSystems Pathways for HK3
        Glycolysis and Gluconeogenesis
    glycolysis
    conversion of glucose to acetyl CoA and entry into the TCA cycle


    1 Reactome Pathway for HK3
        Glucose transport


    Selected Kegg Pathways  (Kegg details for HK3) (see all 12):
        Glycolysis / Gluconeogenesis
    Fructose and mannose metabolism
    Galactose metabolism
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism

    UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790
    Pathway: Carbohydrate metabolism; hexose metabolism

        Pathway & Disease-focused RT2 Profiler PCR Array including HK3: 

              Glucose Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HK3 (P527903 ENSP000002924324) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGFBP4P226923, ENSP000002695934I2D: score=3 STRING: ENSP00000269593
    GRNP287993, ENSP000000538674I2D: score=4 STRING: ENSP00000053867
    PTGDSP412223, ENSP000003606874I2D: score=3 STRING: ENSP00000360687
    HPGDSO607603, ENSP000002952564I2D: score=2 STRING: ENSP00000295256
    LEPP411593, ENSP000003126524I2D: score=3 STRING: ENSP00000312652
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001678cellular glucose homeostasis IBA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006096glycolytic process IEA--
    GO:0008645hexose transport TAS--
    GO:0015758glucose transport TAS--

    Find genes that share ontologies with HK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HK3 (HXK3)

    Selected HMDB Compounds for HK3 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Alpha-D-GlucoseHexopyranose (see all 11)492-62-6--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    Beta-D-Glucoseb-D-Glucopyranose (see all 8)492-61-5--
    Beta-D-Glucose 6-phosphatebeta-D-glucose 6-(dihydrogen phosphate) (see all 3)----
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    D-MannoseDL-mannose (see all 13)3458-28-4--
    Glucosamine2-Amino-2-deoxy-D-glucopyranose (see all 10)3416-24-8--
    Glucosamine 6-phosphate2-Amino-2-deoxy-D-glucose 6-phosphate (see all 14)3616-42-0--

    1 Novoseek inferred chemical compound relationship for HK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 40.2 2 9468341 (1), 12455831 (1)



    Find genes that share compounds with HK3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HK3 gene: 
    NM_002115.2  

    Unigene Cluster for HK3:

    Hexokinase 3 (white cell)
    Hs.411695  [show with all ESTs]
    Unigene Representative Sequence: AB208951
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506834 ENST00000292432(uc003mez.3 uc003mfa.3) ENST00000514666
    ENST00000514058 ENST00000509717 ENST00000504910
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HK3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HK3:
    hsa-miR-942 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidHK3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat HK3
    Clone
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    OriGene ORF clones in mouse, rat for HK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HK3 (NM_002115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HK3
    Addgene plasmids for HK3 
    Primer
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    OriGene qPCR primer pairs and template standards for HK3
    OriGene qSTAR qPCR primer pairs in human, mouse for HK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HK3
      QuantiTect SYBR Green Assays in human, mouse, rat HK3
      QuantiFast Probe-based Assays in human, mouse, rat HK3

    Additional mRNA sequence: 

    AB208951.1 BC028129.1 U51333.1 

    3 DOTS entries:

    DT.441134  DT.100718626  DT.92037217 

    Selected AceView cDNA sequences (see all 67):

    CD370640 CB529448 CB528781 BC028129 CD368453 CD368330 BX095227 NM_002115 
    CB529264 CD368609 AI089249 CA309463 U51333 CB528863 CD367171 CD366037 
    CD368053 BI908489 BQ010955 CA308619 AW467633 BM922932 BG538605 BI910958 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGACCCCT
    HK3 Expression
    About this image


    HK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    HK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411695
        Pathway & Disease-focused RT2 Profiler PCR Array including HK3: 
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HK3
    OriGene qSTAR qPCR primer pairs in human, mouse for HK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HK3
    QuantiTect SYBR Green Assays in human, mouse, rat HK3
    QuantiFast Probe-based Assays in human, mouse, rat HK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HK3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hk31 , 5 hexokinase 31, 5 84.08(n)1
    85.67(a)1
      13 (29.80 cM)5
    2120321  NM_001033245.41  NP_001028417.11 
     550059855 
    chicken
    (Gallus gallus)
    Aves HK31 hexokinase 3 (white cell) 63.07(n)
    56.07(a)
      768421  XM_001231328.3  XP_001231329.3 
    lizard
    (Anolis carolinensis)
    Reptilia HK36
    hexokinase 3 (white cell)
    54(a)
    1 ↔ 1
    GL343526.1(1010-12327)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hex-A3 hexokinase 47(a)
    (best of 4)
      1 8E10   --
    worm
    (Caenorhabditis elegans)
    Secernentea F14B4.23 hexokinase 46(a)
    (best of 3)
      I(9279949-9281838)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HXK1(YFR053C)4 Hexokinase isoenzyme 1, a cytosolic protein that catalyzes more   --   6(255049-253592) 850614  NP_116711.1 


    ENSEMBL Gene Tree for HK3 (if available)
    TreeFam Gene Tree for HK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HK3 gene
    HKDC12  HK22  HK12  GCK2  
    5 SIMAP similar genes for HK3 using alignment to 5 protein entries:     HXK3_HUMAN (see all proteins):
    HK2    DKFZp686M1669    HKDC1    GCK    HK1

    Find genes that share paralogs with HK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HK3 (see all 595)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361874
    A breast cancer sample4--see VAR_0361872 A V mis40--------
    VAR_0361864
    A colorectal cancer sample4--see VAR_0361862 R W mis40--------
    rs2007509381,2
    --176308404(+) ACACCC/TGCCCC 2 A syn10--------
    rs2016953751,2
    C--176308519(+) CCTGCC/TGCAGG 2 Q R mis10--------
    rs2007842431,2
    --176308538(+) GTCACC/TGGGGG 1 -- spa10--------
    rs3768107351,2
    C--176308563(+) AGCACA/GGGGAG 1 -- int10--------
    rs1999335941,2
    C--176308575(+) TGGGTC/TGTGAC 1 -- int10--------
    rs1815487461,2
    C--176308647(+) GTGGAC/TAGAAA 1 -- int10--------
    rs1416535941,2
    C,F--176308655(+) AAAGAC/ACCCCT 1 -- int11Minor allele frequency- A:0.03EU 1270
    rs1461737581,2
    C,F--176308657(+) AGACCC/TCCTGA 1 -- int11Minor allele frequency- T:0.03EU 1277

    HapMap Linkage Disequilibrium report for HK3 (176307870 - 176326333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270879CNV Insertion20981092
    esv273198CNV Insertion20981092
    dgv732n27CNV Loss19166990
    nsv883155CNV Loss21882294
    dgv6377n71CNV Loss21882294
    dgv362n21CNV Loss19592680
    dgv6376n71CNV Loss21882294
    dgv6378n71CNV Loss21882294
    nsv462562CNV Loss19166990
    nsv519416CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142570    OMIM disorders: --


    Find genes that share disorders with HK3           About GenesLikeMe

    Genetic Association Database (GAD): HK3
    Human Genome Epidemiology (HuGE) Navigator: HK3 (56 documents)

    Export disorders for HK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HK3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with HK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. (PubMed id 8812439)1, 2, 3, 9 Furuta H.... Bell G.I. (Genomics 1996)
    2. Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. (PubMed id 8717435)1, 2, 9 Palma F.... Stocchi V. (Mol. Cell. Biochem. 1996)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. (PubMed id 19448621)1, 4 He C....Chasman D.I. (Nat. Genet. 2009)
    5. Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules. (PubMed id 17868400)1, 9 Hooft L....van Diest P.J. (Clin. Endocrinol. (Oxf) 2008)
    6. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PubMed id 9468341)1, 9 Lowes W....Agius L. (Biochim. Biophys. Acta 1998)
    7. Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization. (PubMed id 8941369)1, 9 Colosimo A.... Dallapiccola B. (Cytogenet. Cell Genet. 1996)
    8. PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells. (PubMed id 22498738)1 Federzoni E.A....Tschan M.P. (Blood 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Regulation and cytoprotective role of hexokinase III. (PubMed id 21072205)1 Wyatt E....Ardehali H. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3101 HGNC: 4925 AceView: HK3 Ensembl:ENSG00000160883 euGenes: HUgn3101
    ECgene: HK3 Kegg: 3101 H-InvDB: HK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HK3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hexokinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HK3 gene:
    Search GeneIP for patents involving HK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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