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HK3 Gene(Protein Coding)

Hexokinase 3

GCID:
GC05M176882
GIFtS:
63
Genes Participants
UDN Logo

Aliases for HK3 Gene

Aliases for HK3 Gene

  • Hexokinase 3 2 3 5
  • Hexokinase 3 (White Cell) 2 3
  • Hexokinase Type III 3 4
  • EC 2.7.1.1 4 61
  • HK III 3 4
  • ATP:D-Hexose 6-Phosphotransferase 3
  • Hexokinase-3 3
  • EC 2.7.1 61
  • HKIII 3
  • HXK3 3

External Ids for HK3 Gene

Previous GeneCards Identifiers for HK3 Gene

  • GC05M176681
  • GC05M177150
  • GC05M176243
  • GC05M176288
  • GC05M176240
  • GC05M171230

Summaries for HK3 Gene

Entrez Gene Summary for HK3 Gene

  • Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

GeneCards Summary for HK3 Gene

HK3 (Hexokinase 3) is a Protein Coding gene. Among its related pathways are Citrate cycle (TCA cycle) and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include enzyme binding and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is HK2.

Gene Wiki entry for HK3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HK3 Gene

Genomics for HK3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HK3 Gene

Enhancers for HK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G176816 1.4 FANTOM5 Ensembl ENCODE 11 +81.9 81924 2.7 RAD21 SCRT2 RELB IKZF2 EGR2 SP3 CEBPB ZNF398 ZNF341 IKZF1 HK3 TSPAN17 UNC5A EIF4E1B GC05M176812
GH05G177021 1.2 ENCODE 9.8 -123.2 -123168 2.7 CREB3L1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 SSRP1 ZNF610 GLIS1 FAF2 ENSG00000251414 ENSG00000250909 ZNF346 ENSG00000247679 LOC202181 ZNF346-IT1 RPL21P60 FGFR4 NSD1
GH05G176824 1 FANTOM5 ENCODE 11.4 +76.1 76087 0.3 ZNF263 KLF1 ZNF687 USF1 BHLHE40 USF2 KLF17 ZNF394 RAD51 GABPB1 UNC5A HK3 SNCB EIF4E1B NSD1 GPRIN1 GC05M176812
GH05G176821 0.9 ENCODE 11.4 +76.9 76921 1.3 PKNOX1 NFIB KLF17 GLIS2 RCOR1 FOS EGR2 ZNF263 SMARCB1 ZNF217 HK3 UNC5A GC05M176812
GH05G176646 1 ENCODE 9.8 +251.4 251446 3.0 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF48 YY1 TCF12 GLIS2 GATA2 TSPAN17 GPRIN1 HK3 ENSG00000248484
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HK3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HK3 gene promoter:

Genomic Location for HK3 Gene

Chromosome:
5
Start:
176,880,869 bp from pter
End:
176,899,373 bp from pter
Size:
18,505 bases
Orientation:
Minus strand

Genomic View for HK3 Gene

Genes around HK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HK3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HK3 Gene

Proteins for HK3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52790-HXK3_HUMAN
    Recommended name:
    Hexokinase-3
    Protein Accession:
    P52790
    Secondary Accessions:
    • Q8N1E7

    Protein attributes for HK3 Gene

    Size:
    923 amino acids
    Molecular mass:
    99025 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

    Three dimensional structures from OCA and Proteopedia for HK3 Gene

neXtProt entry for HK3 Gene

Protein Expression for HK3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for HK3 Gene

P52790:
  • EWGAFGD
  • GFTFSFP
  • RAAQLCGAG
  • GFTFSFPC
  • DGSGKGAA
  • NACYMEE
  • LDLGGTNFRV
  • AMVTAVA
  • VNDTVGTMM
  • VGVDGTLYKLHP
  • GQDVVQL
  • GLIVGTG
  • LPLGFTFS
  • MCINMEWGAFGD
  • ALDLGGTN
  • SGMYLGEI

Post-translational modifications for HK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for HK3 Gene

Protein Domains for HK3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52790

UniProtKB/Swiss-Prot:

HXK3_HUMAN :
  • The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.
  • Belongs to the hexokinase family.
Domain:
  • The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.
Family:
  • Belongs to the hexokinase family.
genes like me logo Genes that share domains with HK3: view

No data available for Gene Families for HK3 Gene

Function for HK3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HK3 Gene

GENATLAS Biochemistry:
hexokinase 3,108kDa,expressed in liver,lung,spleen,glycolysis,gluconeogenesis,energy pathways
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-hexose = ADP + D-hexose 6-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.

Enzyme Numbers (IUBMB) for HK3 Gene

Gene Ontology (GO) - Molecular Function for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004340 glucokinase activity TAS --
GO:0004396 hexokinase activity IEA,IDA 8717435
GO:0005524 ATP binding IEA --
GO:0005536 glucose binding IEA --
genes like me logo Genes that share ontologies with HK3: view
genes like me logo Genes that share phenotypes with HK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HK3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HK3 Gene

Localization for HK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HK3 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with HK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HK3 Gene

Pathways & Interactions for HK3 Gene

genes like me logo Genes that share pathways with HK3: view

UniProtKB/Swiss-Prot P52790-HXK3_HUMAN

  • Pathway: Carbohydrate metabolism; hexose metabolism.

Gene Ontology (GO) - Biological Process for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis IEA,IBA --
GO:0005975 carbohydrate metabolic process IEA --
GO:0006096 glycolytic process IEA,IBA --
GO:0008152 metabolic process IEA --
GO:0015758 glucose transport TAS --
genes like me logo Genes that share ontologies with HK3: view

No data available for SIGNOR curated interactions for HK3 Gene

Drugs & Compounds for HK3 Gene

Products:

  1. Drug

(12) Drugs for HK3 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-glucose Approved Pharma 0
Sorbitol Approved Pharma 34
Adenosine triphosphate Approved Nutra 0
Glucosamine Approved Nutra 191
Beta-D-Glucose Experimental Pharma 0

(10) Additional Compounds for HK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
Alpha-D-Glucose
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
 492-62-6
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
 2793-06-8
D-Fructose
  • beta-D-Arabino-hexulose
  • beta-D-Fructofuranose
  • beta-D-Fructose
  • beta-delta-Arabino-hexulose
  • beta-delta-Fructofuranose
 53188-23-1

(1) ApexBio Compounds for HK3 Gene

Compound Action Cas Number
Lonidamine 50264-69-2
genes like me logo Genes that share compounds with HK3: view

Transcripts for HK3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HK3 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HK3 Gene

Hexokinase 3 (white cell):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HK3 Gene

No ASD Table

Relevant External Links for HK3 Gene

GeneLoc Exon Structure for
HK3
ECgene alternative splicing isoforms for
HK3

Expression for HK3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HK3 Gene

mRNA expression in normal human tissues for HK3 Gene
mRNA expression by BioGPS for HK3 GenemRNA expression by GTEx for HK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HK3 Gene

This gene is overexpressed in Whole Blood (x38.4) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for HK3 Gene

This gene is overexpressed in Neutrophil (15.2), Peripheral blood mononuclear cells (11.4), Monocytes (7.9), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HK3 Gene



Protein tissue co-expression partners for HK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HK3 Gene:

HK3

SOURCE GeneReport for Unigene cluster for HK3 Gene:

Hs.411695

Evidence on tissue expression from TISSUES for HK3 Gene

  • Blood(4.4)
  • Liver(4.4)
  • Eye(2.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with HK3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HK3 Gene

Orthologs for HK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HK3 34 35
  • 99.24 (n)
cow
(Bos Taurus)
 Mammalia HK3 35
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia HK3 34 35
  • 88.01 (n)
mouse
(Mus musculus)
 Mammalia Hk3 34 16 35
  • 84.08 (n)
rat
(Rattus norvegicus)
 Mammalia Hk3 34
  • 83.8 (n)
oppossum
(Monodelphis domestica)
 Mammalia HK3 35
  • 74 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia HK3 35
  • 56 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HK3 34 35
  • 63.07 (n)
lizard
(Anolis carolinensis)
 Reptilia HK3 35
  • 54 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Hex-A 36 35
  • 47 (a)
Hex-t2 36 35
  • 42 (a)
Hex-C 36 35
  • 41 (a)
Hex-t1 36
  • 31 (a)
worm
(Caenorhabditis elegans)
 Secernentea F14B4.2 36 35
  • 46 (a)
H25P06.1 36
  • 41 (a)
Y77E11A.1 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes EMI2 35
  • 29 (a)
 ManyToMany
GLK1 35
  • 29 (a)
 ManyToMany
HXK1 35 37
  • 28 (a)
 ManyToMany
HXK2 35
  • 27 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.11095 35
  • 40 (a)
 OneToMany
Species where no ortholog for HK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HK3 Gene

ENSEMBL:
Gene Tree for HK3 (if available)
TreeFam:
Gene Tree for HK3 (if available)

Paralogs for HK3 Gene

Paralogs for HK3 Gene

(5) SIMAP similar genes for HK3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HK3: view

Variants for HK3 Gene

Sequence variations from dbSNP and Humsavar for HK3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs376532514 A colorectal cancer sample 176,887,613(+) GCGCC(A/C/G)GTGGG nc-transcript-variant, reference, missense
rs755546220 A breast cancer sample 176,887,555(+) GAACC(A/G)CAGCC nc-transcript-variant, reference, missense
rs757892659 Likely benign 176,883,788(+) TATCT(C/T)GCAAC nc-transcript-variant, downstream-variant-500B, reference, missense
rs1000053364 -- 176,896,873(+) ACAAG(A/G)TTGTT intron-variant
rs1000118772 -- 176,890,417(+) CTGAA(C/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HK3 Gene

Variant ID Type Subtype PubMed ID
dgv10180n54 CNV loss 21841781
dgv10181n54 CNV loss 21841781
dgv362n21 CNV loss 19592680
dgv732n27 CNV loss 19166990
esv3306603 CNV mobile element insertion 20981092
esv3308925 CNV mobile element insertion 20981092
esv3326187 CNV insertion 20981092
esv3332381 CNV insertion 20981092
esv3575904 CNV gain 25503493
nsv462562 CNV loss 19166990
nsv519416 CNV gain 19592680
nsv600353 CNV loss 21841781
nsv950724 CNV deletion 24416366

Variation tolerance for HK3 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HK3 Gene

Disorders for HK3 Gene

Relevant External Links for HK3

Genetic Association Database (GAD)
HK3
Human Genome Epidemiology (HuGE) Navigator
HK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HK3

No disorders were found for HK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HK3 Gene

Publications for HK3 Gene

  1. Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. (PMID: 8812439) Furuta H. … Bell G.I. (Genomics 1996) 2 3 4 22 64
  2. Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. (PMID: 8717435) Palma F. … Stocchi V. (Mol. Cell. Biochem. 1996) 3 4 22 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. (PMID: 19448621) He C. … Chasman D.I. (Nat. Genet. 2009) 3 46 64
  5. Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules. (PMID: 17868400) Hooft L. … van Diest P.J. (Clin. Endocrinol. (Oxf) 2008) 3 22 64

Products for HK3 Gene

  • Addgene plasmids for HK3

Sources for HK3 Gene

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