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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HK3 Gene

protein-coding GIFtS: 67
GCID: GC05M176240

hexokinase 3 (white cell)

Explore 7 diseases affiliated with
HK3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hexokinase 3 (White Cell)¹ ²		HXK3²
Hexokinase Type III² ³		ATP:D-Hexose 6-Phosphotransferase²
HK III² ³		Hexokinase-3¹
EC 2.7.1.1³ ⁸		EC 2.7.1⁸
HKIII²

External Ids:	HGNC: 4925¹	Entrez Gene: 3101²	Ensembl: ENSG00000160883⁷	OMIM: 142570⁵	UniProtKB: P52790³

Export aliases for HK3 gene to outside databases

Previous GC identifers: GC05M176681 GC05M177150 GC05M176243 GC05M176288 GC05M171230

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HK3:

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways.

This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product

glucose-6-phosphate. (provided by RefSeq, Apr 2009)

Gene Wiki entry for HK3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HK3 gene promoter:
GR Pbx1a MIF-1 POU2F1 POU2F1a POU2F1b PPAR-gamma2 GR-alpha POU2F1c MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HK3 promoter sequence

Search SABiosciences Chromatin IP Primers for HK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.2

HK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HK3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M176240: view genomic region (about GC identifiers)

Start:	176,307,870 bp from pter	End:	176,326,333 bp from pter
Size:	18,464 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790 (See protein sequence)

Recommended Name: Hexokinase-3

Size: 923 amino acids; 99025 Da

Subunit: Monomer (By similarity)

Miscellaneous: In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III

and IV (glucokinase)

1 PDB 3D structure from and Proteopedia for HK3:

3HM8 (3D)

Secondary accessions: Q8N1E7

Explore the universe of human proteins at neXtProt for HK3: NX_P52790

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52790

4/16 DME Specific Peptides for HK3 (P52790) (see all 16)

GQDVVQL

EWGAFGD

GLIVGTG

AMVTAVA

HK3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002106.2

ENSEMBL proteins:

ENSP00000292432 ENSP00000424632 ENSP00000422169 ENSP00000427000

Reactome Protein details: P52790
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for HK3
	Novus Biologicals HK3 Proteins Novus Biologicals HK3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HK3
	Uscn Proteins for HK3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	NAS	--
GO:0043234	protein complex	IEA	--

HK3 for ontologies About GeneDecksing

HK3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HK3
	Browse R&D Systems for Antibodies
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	GenScript Custom Superior Antibodies Services for HK3
	Novus Biologicals HK3 Antibodies
	Abcam antibodies for HK3
	Uscn Antibodies for HK3
	ThermoFisher Antibodies for HK3

Assay Products for HK3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HK3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HK3 for domains About GeneDecksing

4 InterPro domains/families:

IPR019807 Hexokinase_CS

IPR001312 Hexokinase

IPR022672 Hexokinase_N

IPR022673 Hexokinase_C

Graphical View of Domain Structure for InterPro Entry P52790

ProtoNet protein and cluster: P52790

1 Blocks protein family: IPB001312 Hexokinase

UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790

Domain: The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic

activity is associated with the C-terminus while regulatory function is associated with the N-terminus

Similarity: Belongs to the hexokinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790

Catalytic activity: ATP + D-hexose = ADP + D-hexose 6-phosphate

Enzyme regulation: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P

Genatlas biochemistry entry for HK3:

hexokinase 3,108kDa,expressed in liver,lung,spleen,glycolysis,gluconeogenesis,energy pathways

Enzyme Numbers (IUBMB): EC 2.7.1.1¹ ² EC 2.7.1²

miRNA Products:		OriGene 3'-UTR Clone: HK3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HK3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HK3:
		hsa-miR-942 hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: HK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HK3 (see all 7) OriGene shRNA RFP: HK3 OriGene siRNA: HK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HK3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HK3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HK3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HK3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HK3 (NM_002115)
		Sino Biological Human cDNA Clone for HK3
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HK3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HK3
		Search LifeMap BioReagents cell lines for HK3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK3

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004340	glucokinase activity	IBA	--
GO:0004396	hexokinase activity	NAS	--
GO:0005524	ATP binding	NAS	--
GO:0008865	fructokinase activity	IBA	--
GO:0016301	kinase activity	--	--

HK3 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for HK3:

Decreased TP53 protein express

Increased cell death HMECs cel

Increased cell number in G2M,

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Galactose metabolism

Galactose metabolism	1.00	Glycogen metabolism	0.40
Galactose metabolism	0.95	Glycogen metabolism	0.40
Galactose metabolism	0.47

Glycolysis and gluconeogenesis (short map)

	Glycolysis and gluconeogenesis (short map)	1.00			Glycolysis and Gluconeogenesis	0.60
	Glycolysis and gluconeogenesis (short map)	0.97			Glycolysis / Gluconeogenesis	0.41

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

Glucose transport

0.57

Hexose transport

0.55

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HK3

	Glycogen metabolism
	Glycolysis and gluconeogenesis (short map)
	Galactose metabolism

3 GeneGo (Thomson Reuters) Pathways for HK3

	Galactose metabolism
	Glycogen metabolism
	Glycolysis and gluconeogenesis (short map)

1 BioSystems Pathway for HK3

Glycolysis and Gluconeogenesis

5/6 Reactome Pathways for HK3 (see all 6)

	Metabolism of carbohydrates
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Hexose transport
	Metabolism

5/10 Kegg Pathways (Kegg details for HK3) (see all 10):

	Glycolysis / Gluconeogenesis
	Fructose and mannose metabolism
	Galactose metabolism
	Starch and sucrose metabolism
	Amino sugar and nucleotide sugar metabolism

UniProtKB/Swiss-Prot: HXK3_HUMAN, P52790

Pathway: Carbohydrate metabolism; hexose metabolism

HK3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HK3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/61 Interacting proteins for HK3 (P52790³ ENSP00000292432⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGFBP4	P22692³, ENSP00000269593⁴	I2D: score=3 STRING: ENSP00000269593
GRN	P28799³, ENSP00000053867⁴	I2D: score=4 STRING: ENSP00000053867
PTGDS	P41222³, ENSP00000360687⁴	I2D: score=3 STRING: ENSP00000360687
HPGDS	O60760³, ENSP00000295256⁴	I2D: score=2 STRING: ENSP00000295256
LEP	P41159³, ENSP00000312652⁴	I2D: score=3 STRING: ENSP00000312652

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001678	cellular glucose homeostasis	IBA	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006096	glycolysis	NAS	--
GO:0008645	hexose transport	TAS	--
GO:0015758	glucose transport	TAS	--

HK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HK3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HK3

10/18 HMDB Compounds for HK3 (see all 18) About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Alpha-D-Glucose	Hexopyranose (see all 11)	492-62-6	--
Beta-D-Fructose 6-phosphate	beta-D-Fructose 6-phosphate (see all 2)	--	--
Beta-D-Glucose	b-D-Glucopyranose (see all 8)	492-61-5	--
Beta-D-Glucose 6-phosphate	beta-D-glucose 6-(dihydrogen phosphate) (see all 3)	--	--
D-Glucose	(+)-Glucose (see all 23)	50-99-7	--
D-Mannose	DL-mannose (see all 13)	3458-28-4	--
Glucosamine	2-Amino-2-deoxy-D-glucopyranose (see all 10)	3416-24-8	--
Glucosamine 6-phosphate	2-Amino-2-deoxy-D-glucose 6-phosphate (see all 14)	3616-42-0	--

1 Novoseek chemical compound relationship for HK3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	40.2	2	9468341 (1), 12455831 (1)

Search CenterWatch for drugs/clinical trials and news about HK3 / HXK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HK3 gene:

NM_002115.2

Unigene Cluster for HK3:

Hexokinase 3 (white cell)

Hs.411695 [show with all ESTs]

Unigene Representative Sequence: AB208951

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506834 ENST00000292432(uc003mez.3 uc003mfa.3) ENST00000514666

ENST00000514058 ENST00000509717 ENST00000504910

miRNA Products:		OriGene 3'-UTR Clone: HK3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HK3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HK3:
		hsa-miR-942 hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: HK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HK3 (see all 7) OriGene shRNA RFP: HK3 OriGene siRNA: HK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HK3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HK3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HK3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HK3 (NM_002115)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HK3

Additional cDNA sequence:

AB208951.1 BC028129.1 U51333.1

3 DOTS entries:

DT.441134 DT.100718626 DT.92037217

24/67 AceView cDNA sequences (see all 67):

CD368609 CB529448 AI089249 BX095227 CD366037 U51333 NM_002115 CD368053

CB529264 CA309463 CB528781 CD368453 CB528863 CD370640 CD367171 CD368330

BC028129 BG538605 CA308619 BG231919 CD614072 CF528306 BM997997 AL597571

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGACCCCT

About this image

HK3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Interstitial Stroma

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HK3

SOURCE GeneReport for Unigene cluster: Hs.411695

SABiosciences Expression via Pathway-Focused PCR Array including HK3:

Glucose Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HK3
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HK3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HK3 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hk3^{1 , 5}	hexokinase 3^{1, 5}	84.08(n)¹ 85.67(a)¹		13 (29.80 cM)⁵ 212032¹ NM_001206390.1¹ NP_001193319.1¹ 55005985⁵
chicken (Gallus gallus)	Aves	LOC768421¹	hexokinase-3-like	63.07(n) 56.07(a)		768421 XM_001231328.2 XP_001231329.2
lizard (Anolis carolinensis)	Reptilia	HK3⁶	--	53(a)	1 ↔ 1	GL343526.1(1080-12327)
fruit fly (Drosophila melanogaster)	Insecta	Hex-A³	hexokinase	47(a) (best of 4)		1 8E10 --
worm (Caenorhabditis elegans)	Secernentea	F14B4.2³	hexokinase	46(a) (best of 3)		I(9279949-9281838) --
thale cress (Arabidopsis thaliana)	eudicotyledons	HXK3⁶ ATHXK1⁶ (see all 6)	hexokinase 1 (see all 6)	34(a) 32(a) (see all 6)	many ↔ many many ↔ many (see all 6)	1(17616107-17618894) 4(14352037-14355103)
rice (Oryza sativa)	Liliopsida	Os07g0446800¹	hypothetical protein	51.47(n) 41.86(a)		4343113 NM_001066073.1 NP_001059538.1

ENSEMBL Gene Tree for HK3 (if available)
TreeFam Gene Tree for HK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HK3 gene

HK2² HKDC1² HK1² GCK²

5 SIMAP similar genes for HK3 using alignment to 5 protein entries: HXK3_HUMAN (see all proteins):

HK2 DKFZp686M1669 HKDC1 GCK HK1

HK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181063240^1,2		--	176307370(+)	`CAGCCA/GGACAG`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs141073522^1,2		--	176307455(+)	`ACACAC/TCCCCC`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs115654995^1,2	F,	--	176307458(+)	`CACCCC/TCCTCC`	2	--	ds500¹ ut3¹		1		WA	118
rs115453693^1,2	C,	--	176307464(+)	`CCTCCC/TGGGTC`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs3736432^1,2	C,F,A,H,	--	176307504(-)	`TGTACG/AGCATG`	2	--	ds500¹ ut3¹		26		EA NS NA WA CSA	3243
rs114188458^1,2	F,	--	176307532(+)	`CTCACG/ACCCAG`	2	--	ds500¹ ut3¹		1		NA	120
rs138975226^1,2		--	176307726(+)	`CCCAGA/GGCTGG`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs77402583^1,2	C,	--	176307757(+)	`TGTCAT/CGTGAA`	2	--	ut3¹ ds500¹		3		WA CSA	121
rs11540627^1,2	C,F,	--	176307963(-)	`CCATGT/CGTGAC`	2	--	ds500¹ ut3¹		2		WA NA	238
rs187171975^1,2	C,	--	176308027(+)	`GACCCG/AGCTCC`	2	--	ds500¹ ut3¹		1		EU	100

HapMap Linkage Disequilibrium report for HK3 (176307870 - 176326333 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HK3
3 CNVs: 51637 53250 51636

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HK3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HK3 for disorders           About GeneDecksing

OMIM gene information: 142570    OMIM disorders: --

7 diseases for HK3:    About MalaCards

thyroiditis lung cancer breast cancer schizophrenia

adenocarcinoma malaria alcoholism

Human Genome Epidemiology (HuGE) Navigator: HK3 (56 documents)

Export disorders for HK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HK3 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with HK3)

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Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. (PubMed id 8812439)^{1, 2, 3, 9} Furuta H.... Bell G.I. (1996)
Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. (PubMed id 8717435)^{1, 2, 9} Palma F.... Stocchi V. (1996)
Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules. (PubMed id 17868400)^{1, 9} Hooft L....van Diest P.J. (2008)
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PubMed id 9468341)^{1, 9} Lowes W....Agius L. (1998)
Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization. (PubMed id 8941369)^{1, 9} Colosimo A....Dallapiccola B. (1996)
PU.1 is linking the glycolytic enzyme HK3 in neutrophi l differentiation and survival of APL cells. (PubMed id 22498738)¹ Federzoni E.A....Tschan M.P. (2012)
Regulation and cytoprotective role of hexokinase III. (PubMed id 21072205)¹ Wyatt E....Ardehali H. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Genome-wide association studies identify loci associa ted with age at menarche and age at natural menopause. (PubMed id 19448621)¹ He C....Chasman D.I. (2009)
Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. (PubMed id 19554504)¹ Fonteyne P....Van de Wiele C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3101	HGNC: 4925	AceView: HK3	Ensembl:ENSG00000160883	euGenes: HUgn3101
ECgene: HK3	Kegg: 3101	H-InvDB: HK3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HK3	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Hexokinase

Intellectual Property for HK3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HK3 gene:
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GeneCards and IP:
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