Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HK2 Gene

protein-coding   GIFtS: 73
GCID: GC02P075059

Hexokinase 2

  See HK2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hexokinase 21 2     HKII2
Hexokinase Type II2 3     HXK22
Muscle Form Hexokinase2 3     hexokinase-22
HK II2 3     Hexokinase-2, Muscle2
EC 2.7.1.13 8     EC 2.7.18

External Ids:    HGNC: 49231   Entrez Gene: 30992   Ensembl: ENSG000001593997   OMIM: 6011255   UniProtKB: P527893   

Export aliases for HK2 gene to outside databases

Previous GC identifers: GC02P075198 GC02P075018 GC02P075035 GC02P075034 GC02P074971 GC02P074796


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HK2 Gene:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism
pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the
outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it
is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. (provided by RefSeq, Apr
2009)

GeneCards Summary for HK2 Gene:
HK2 (hexokinase 2) is a protein-coding gene. Diseases associated with HK2 include chondroblastoma, and pancreatic cancer. GO annotations related to this gene include fructokinase activity and glucose binding. An important paralog of this gene is HK3.

summary for HK2 Gene:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for HK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HK2 gene promoter:
         HOXA9   HOXA9B   Sox5   HOXA3   AML1a   Bach2   Evi-1   Zic1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HK2 promoter sequence
   Search Chromatin IP Primers for HK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p13

HK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HK2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P075059:  view genomic region     (about GC identifiers)

Start:
75,059,782 bp from pter      End:
75,120,486 bp from pter
Size:
60,705 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HXK2_HUMAN, P52789 (See protein sequence)
Recommended Name: Hexokinase-2  
Size: 917 amino acids; 102380 Da
Subunit: Monomer (By similarity)
Miscellaneous: In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I,
II, III and IV (glucokinase)
1 PDB 3D structure from and Proteopedia for HK2:
2NZT (3D)    
Secondary accessions: D6W5J2 Q8WU87 Q9UN82

Explore the universe of human proteins at neXtProt for HK2: NX_P52789

Explore proteomics data for HK2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys41, Lys62, Lys173, Lys323, Lys488, Lys899
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HK2 (P52789) (see all 47)
     DIRTEFD  PDGTEKG  EWGAFGD  TMMTCGY 


    See HK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000180.2  
    ENSEMBL proteins: 
     ENSP00000290573   ENSP00000387140  
    Reactome Protein details: P52789

    HK2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HK2 (Hexokinase 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HK2
    OriGene Protein Over-expression Lysate for HK2
    OriGene MassSpec for HK2
    OriGene Custom Protein Services for HK2
    GenScript Custom Purified and Recombinant Proteins Services for HK2
    Novus Biologicals HK2 Proteins
    Novus Biologicals HK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HK2
    Cloud-Clone Corp. Proteins for HK2

     
    Search eBioscience for Proteins for HK2 

     
    antibodies-online proteins for HK2 (24 products) 

     
    antibodies-online peptides for HK2

    HK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HK2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HK2 
    OriGene Antibodies for HK2
    OriGene Custom Antibody Services for HK2
    Novus Biologicals HK2 Antibodies
    Abcam antibodies for HK2
    Cloud-Clone Corp. Antibodies for HK2
    ThermoFisher Antibody for HK2
    antibodies-online antibodies for HK2 (99 products) 

    HK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HK2
    Cloud-Clone Corp. CLIAs for HK2
    Search eBioscience for ELISAs for HK2 
    antibodies-online kits for HK2 (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR019807 Hexokinase_CS
     IPR001312 Hexokinase
     IPR022672 Hexokinase_N
     IPR022673 Hexokinase_C

    Graphical View of Domain Structure for InterPro Entry P52789

    ProtoNet protein and cluster: P52789

    1 Blocks protein domain: IPB001312 Hexokinase

    UniProtKB/Swiss-Prot: HXK2_HUMAN, P52789
    Domain: The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The
    catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.
    Each domain can bind a single glucose and Gluc-6-P molecule
    Similarity: Belongs to the hexokinase family
    Similarity: Contains 2 hexokinase type-1 domains
    Similarity: Contains 2 hexokinase type-2 domains


    Find genes that share domains with HK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXK2_HUMAN, P52789
    Catalytic activity: ATP + D-hexose = ADP + D-hexose 6-phosphate
    Enzyme regulation: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P

         Genatlas biochemistry entry for HK2:
    hexokinase 2,108kDa,muscle and fat tissues,glycolysis,gluconeogenesis,energy pathways

         Enzyme Numbers (IUBMB): EC 2.7.1.11 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004340glucokinase activity IBA--
    GO:0004396hexokinase activity TAS9278438
    GO:0005524ATP binding IEA--
    GO:0005536glucose binding IEA--
    GO:0008865fructokinase activity IBA--
         
    Find genes that share ontologies with HK2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HK2:
     Increased HPV18 LCR reporter a  Increased Hepatitis C virus re 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hk2):
     embryogenesis  growth/size/body  mortality/aging  normal 

    Find genes that share phenotypes with HK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hk2tm1Laak for HK2

       genOway: Develop your customized and physiologically relevant rodent model for HK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HK2:
    hsa-mir-484 (MIRT041885), hsa-mir-375 (MIRT019914), hsa-mir-98-5p (MIRT027665), hsa-mir-125b-5p (MIRT006945), hsa-mir-143-3p (MIRT006301), hsa-mir-155-5p (MIRT020800), hsa-mir-125a-5p (MIRT006944)

    Block miRNA regulation of human, mouse, rat HK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HK2 (see all 39):
    hsa-miR-323-3p hsa-let-7d hsa-miR-765 hsa-miR-10b* hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidHK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HK2
    Predesigned siRNA for gene silencing in human, mouse, rat HK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HK2

    Clone
    Products:
         
    OriGene clones in human, mouse for HK2 (see all 7)
    OriGene ORF clones in mouse, rat for HK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HK2 (NM_000189)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HK2
    Addgene plasmids for HK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10169) for HK2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HXK2_HUMAN, P52789: Mitochondrion outer membrane (By similarity). Note=Its hydrophobic N-terminal sequence may
    be involved in membrane binding (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    nucleus2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane IDA18350175
    GO:0005829cytosol TAS--

    Find genes that share ontologies with HK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HK2 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    2Galactose metabolism
    Galactose metabolism0.44
    Butirosin and neomycin biosynthesis0.00
    Galactose metabolism0.44
    3Glucuronidation
    Starch and sucrose metabolism0.41
    Glycogen metabolism0.00
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Hexose transport0.87


    Find genes that share SuperPaths with HK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HK2
        Glucose / Energy Metabolism

    4 GeneGo (Thomson Reuters) Pathways for HK2
        Galactose metabolism
    Glycogen metabolism
    Glycolysis and gluconeogenesis (short map)
    Transcription CREM signaling in testis

    2 BioSystems Pathways for HK2
        Glycolysis and Gluconeogenesis
    HIF-1-alpha transcription factor network

    1 Reactome Pathway for HK2
        Glucose transport


    Selected Kegg Pathways  (Kegg details for HK2) (see all 12):
        Glycolysis / Gluconeogenesis
    Fructose and mannose metabolism
    Galactose metabolism
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism

    UniProtKB/Swiss-Prot: HXK2_HUMAN, P52789
    Pathway: Carbohydrate metabolism; hexose metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HK2 (see all 8): 

              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HK2 (P527892, 3 ENSP000002905734) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX02, 3, ENSP000003655764MINT-66168 I2D: score=5 STRING: ENSP00000365576
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2859660 I2D: score=3 STRING: ENSP00000357292
    SLC2A4P146723, ENSP000003209354I2D: score=3 STRING: ENSP00000320935
    PRKCEQ021563, ENSP000003061244I2D: score=2 STRING: ENSP00000306124
    PTGDSP412223, ENSP000003606874I2D: score=3 STRING: ENSP00000360687
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001678cellular glucose homeostasis IBA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process ----
    GO:0006096glycolytic process IBA--
    GO:0007595lactation IEA--

    Find genes that share ontologies with HK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    2-Deoxy-D-glucoseNon-metabolizable glucose analog; hexokinase substrate[154-17-6]
    LonidamineMitochondrial hexokinase inhibitor[50264-69-2]

    Selected HMDB Compounds for HK2 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Alpha-D-GlucoseHexopyranose (see all 11)492-62-6--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    Beta-D-Glucoseb-D-Glucopyranose (see all 8)492-61-5--
    Beta-D-Glucose 6-phosphatebeta-D-glucose 6-(dihydrogen phosphate) (see all 3)----
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    D-MannoseDL-mannose (see all 13)3458-28-4--
    Glucosamine2-Amino-2-deoxy-D-glucopyranose (see all 10)3416-24-8--
    Glucosamine 6-phosphate2-Amino-2-deoxy-D-glucose 6-phosphate (see all 14)3616-42-0--

    Selected Novoseek inferred chemical compound relationships for HK2 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-bromopyruvate 90.3 17 19285479 (3), 19067133 (2), 15710218 (1), 20392992 (1) (see all 5)
    glucose 6-phosphate 76.7 17 8567628 (1), 10442567 (1), 15752986 (1), 7883123 (1) (see all 14)
    glucose 73 190 17064576 (4), 7883123 (3), 8786021 (3), 18250992 (3) (see all 80)
    glycogen 69 26 9837860 (2), 15833942 (1), 16288047 (1), 11319725 (1) (see all 18)
    mannoheptulose 53.5 1 10680171 (1)
    18f fluorodeoxyglucose 46.9 7 15967114 (1), 18250992 (1)
    atp 46.2 13 16892090 (2), 15691486 (1), 15710218 (1), 19140804 (1) (see all 8)
    pyruvate 44.9 12 17785433 (2), 7589821 (1), 20394812 (1), 17352240 (1) (see all 7)
    2-deoxyglucose 31.8 3 15781061 (1), 18694801 (1), 8772513 (1)
    lactate 31.8 4 15752986 (1), 20137345 (1), 19690031 (1), 16782875 (1)



    Find genes that share compounds with HK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HK2 gene: 
    NM_000189.4  

    Unigene Clusters for HK2:

    Hexokinase 2
    Hs.406266  [show with all ESTs], Hs.591588  [show with all ESTs]
    Unigene Representative Sequences: AF086198, NM_000189
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290573(uc002snd.3) ENST00000409174 ENST00000472302
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HK2 (see all 39):
    hsa-miR-323-3p hsa-let-7d hsa-miR-765 hsa-miR-10b* hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidHK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HK2
    Predesigned siRNA for gene silencing in human, mouse, rat HK2
    Clone
    Products:
         
    OriGene clones in human, mouse for HK2 (see all 7)
    OriGene ORF clones in mouse, rat for HK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HK2 (NM_000189)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HK2
    Addgene plasmids for HK2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HK2
    OriGene qSTAR qPCR primer pairs in human, mouse for HK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HK2
      QuantiTect SYBR Green Assays in human, mouse, rat HK2
      QuantiFast Probe-based Assays in human, mouse, rat HK2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10169) for HK2 

    Additional mRNA sequence: 

    AF148513.1 AK290357.1 BC021116.1 BC064369.1 CR749202.1 

    13 DOTS entries:

    DT.100795595  DT.86837439  DT.304276  DT.91706939  DT.95180545  DT.100662368  DT.86849417  DT.97785770 
    DT.403480  DT.92025746  DT.100795592  DT.121317811  DT.40190736 

    Selected AceView cDNA sequences (see all 216):

    CD172044 AA095639 AA470096 AW236997 BM692852 AA337776 BM706373 BF115343 
    BQ645077 AI085541 BQ215676 AA534934 AA370200 AI918721 AI082057 BG104295 
    AI673124 BE140868 BF509247 NM_000189 AF148513 BC064369 AA774416 CD742564 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTGCTTT
    HK2 Expression
    About this image


    HK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    HK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HK2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.406266 Hs.591588

    UniProtKB/Swiss-Prot: HXK2_HUMAN, P52789
    Tissue specificity: Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HK2 (see all 8): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HK2
    OriGene qSTAR qPCR primer pairs in human, mouse for HK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HK2
    QuantiTect SYBR Green Assays in human, mouse, rat HK2
    QuantiFast Probe-based Assays in human, mouse, rat HK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HK2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hk21 , 5 hexokinase 21, 5 87.28(n)1
    94.22(a)1
      6 (35.94 cM)5
    152771  NM_013820.31  NP_038848.11 
     827250255 
    chicken
    (Gallus gallus)
    Aves HK21 hexokinase 2 80.28(n)
    86.03(a)
      374044  NM_204212.1  NP_989543.1 
    lizard
    (Anolis carolinensis)
    Reptilia HK26
    hexokinase 2
    82(a)
    1 ↔ 1
    GL343662.1(151389-167406)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX770213.12   -- 71.98(n)    BX770213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.105532 Danio rerio mRNA similar to hexokinase 2 (cDNA clone MGC55926 IMAGE3819168), complete cds less 75.49(n)    BC045496.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hex-A3 hexokinase 48(a)
    (best of 4)
      1 8E10   --
    worm
    (Caenorhabditis elegans)
    Secernentea F14B4.21 , 3 hexokinase3
    F14B4.21
    48(a)
    (best of 3)3
    54.12(n)1
    51.7(a)1
      I(9279949-9281838)3
    1727511  NM_001025936.31  NP_001021107.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLK16
    HXK16
    (see all 4)
    Glucokinase, catalyzes the phosphorylation of gluc...
    Hexokinase isoenzyme 1, a cytosolic protein that c...
    (see all 4)
    34(a)
    34(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    III(50838-52340) YCL040W
    VI(253592-255049) YFR053C
    rice
    (Oryza sativa)
    Liliopsida NM_191156.12   -- 73.46(n)    NM_191156.1 


    ENSEMBL Gene Tree for HK2 (if available)
    TreeFam Gene Tree for HK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HK2 gene
    HK32  HKDC12  HK12  GCK2  
    5 SIMAP similar genes for HK2 using alignment to 4 protein entries:     HXK2_HUMAN (see all proteins):
    DKFZp686M1669    HKDC1    HK1    GCK    HK3

    Find genes that share paralogs with HK2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HK2
    PGOHUM00000241413


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    HXK2_HUMAN, P52789: Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease


    Selected SNPs for HK2 (see all 1660)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283630551,2
    C,F--74985762(+) AGGATGGGG    
       GCC
    /-
    CTACA
    1 -- int11Minor allele frequency- -:0.16NS 180
    rs1843254321,2
    --75057801(+) CATGCA/GTCAGG 1 -- us2k10--------
    rs1430966221,2
    C--75057870(+) AGCTTA/CTCATC 1 -- us2k10--------
    rs744407721,2
    C,F--75057978(+) AAAGCC/GTGATG 1 -- us2k11Minor allele frequency- G:0.14WA 118
    rs1481930301,2
    --75058029(+) GACTCA/GGGACC 1 -- us2k10--------
    rs771271061,2
    C,F--75058048(+) GATTAG/CAGTTC 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs1886746231,2
    --75058129(+) CTAGAA/CATTTC 1 -- us2k10--------
    rs108654031,2
    C,H--75058142(+) tataaT/Cctgcc 1 -- us2k113Minor allele frequency- C:0.22NA WA CSA EA 378
    rs781936821,2
    C,F--75058160(+) TTGCAT/AGTTAA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1809859151,2
    C--75058175(+) AAGTGG/TGTAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HK2 (75059782 - 75120486 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677814CNV Deletion23128226
    esv2659874CNV Deletion23128226
    nsv829465CNV Loss20364138
    nsv519007CNV Loss19592680
    dgv4168n71CNV Gain21882294
    nsv874296CNV Gain21882294
    esv2751900CNV Gain17911159
    nsv874292CNV Gain21882294
    nsv518615CNV Gain19592680

    Human Gene Mutation Database (HGMD): HK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HK2
    DNA2.0 Custom Variant and Variant Library Synthesis for HK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601125    OMIM disorders: --

    2 diseases for HK2:    
    About MalaCards
    chondroblastoma    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for HK2:
    Diabetes mellitus

    Find genes that share disorders with HK2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HK2 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 54.4 49 9519744 (5), 8675629 (5), 8786021 (4), 7883120 (4) (see all 12)
    insulin sensitivity 52.3 5 16763003 (2), 7883123 (1), 17088412 (1)
    insulin resistance 48.3 19 8786021 (2), 8834247 (2), 10656921 (2), 7589821 (1) (see all 12)
    cancer 42.3 47 18780167 (3), 18979289 (3), 16892090 (3), 12893819 (3) (see all 23)
    tumors 38.6 75 12871125 (4), 18982473 (4), 10946615 (3), 19690031 (3) (see all 30)
    hyperinsulinemia 37.2 9 11287353 (2), 17088412 (2), 7883122 (1), 10877213 (1)
    hepatocellular carcinoma 33.9 15 18357395 (2), 18250992 (2), 15710218 (1), 19690031 (1) (see all 7)
    pancreatic cancer 25 9 17530485 (3), 11688991 (1), 11850481 (1), 18347186 (1) (see all 6)
    necrosis 14.9 2 14672622 (1)
    glioma 12.8 2 15781061 (1), 16899068 (1)

    Genetic Association Database (GAD): HK2
    Human Genome Epidemiology (HuGE) Navigator: HK2 (36 documents)

    Export disorders for HK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HK2 gene, integrated from 10 sources (see all 258):
    (articles sorted by number of sources associating them with HK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Amino acid substitutions in hexokinase II among patients with NIDDM. (PubMed id 7883120)1, 2, 4, 9 Laakso M.... Deeb S.S. (Diabetes 1995)
    2. Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution. (PubMed id 7883122)1, 2, 4, 9 Vidal-Puig A.... Moller D.E. (Diabetes 1995)
    3. Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity. (PubMed id 7883123)1, 2, 4, 9 Echwald S.M.... Pedersen O. (Diabetes 1995)
    4. Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity. (PubMed id 8786021)1, 2, 9 Lehto M.... Groop L.C. (Diabetologia 1995)
    5. Human hexokinase II: sequence and homology to other hexokinases. (PubMed id 8250948)1, 2, 9 Deeb S.S.... Laakso M. (Biochem. Biophys. Res. Commun. 1993)
    6. Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines. (PubMed id 7518342)1, 2, 9 Shinohara Y.... Terada H. (Cancer Lett. 1994)
    7. Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer. (PubMed id 20845477)1, 4 Dong X....Li D. (Cancer 2011)
    8. Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass. (PubMed id 22087292)1, 4 Sun L....Deng H.W. (PLoS ONE 2011)
    9. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3099 HGNC: 4923 AceView: HK2 Ensembl:ENSG00000159399 euGenes: HUgn3099
    ECgene: HK2 Kegg: 3099 H-InvDB: HK2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HK2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hk2/
    Wikipedia http://en.wikipedia.org/wiki/Hexokinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HK2 gene:
    Search GeneIP for patents involving HK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HK2
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for HK2 (Hexokinase 2)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HK2   OriGene RNAi products in human, mouse, rat for HK2  
     OriGene qPCR primer pairs and template standards for HK2   OriGene Protein Over-expression Lysate for HK2  
     OriGene MassSpec for HK2   OriGene clones in human, mouse for HK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for HK2   OriGene Purified Protein for HK2  
     OriGene ORF clones in mouse, rat for HK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HK2   OriGene Custom Protein Services for HK2  

     
     
     Block miRNA regulation of human, mouse, rat HK2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HK2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HK2 Predesigned siRNA for gene silencing in human, mouse, rat HK2
     QuantiFast Probe-based Assays in human, mouse, rat HK2 QuantiTect SYBR Green Assays in human, mouse, rat HK2
     PCR Arrays including human, mouse, rat HK2 Search Chromatin IP Primers for HK2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HK2  GeneGlobe Interaction Network for HK2
     Regulatory tfbs in HK2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HK2 GenScript cDNA clones with any tag delivered in your preferred vector for HK2
     GenScript Custom Assay Services for HK2 GenScript Custom overexpressing Cell Line Services for HK2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for HK2 

     Tocris compounds for HK2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HK2 antibodies
     HK2 proteins
     HK2 lysates
     Antibodies for HK2
     See all of Abcam's Antibodies, Kits and Proteins for HK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HK2
     Proteins for HK2
     Antibodies for HK2
     ELISAs for HK2
     CLIAs for HK2



     Browse ESI BIO Cell Lines and PureStem Progenitors for HK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HK2
     SwitchGear 3'UTR luciferase reporter plasmids for HK2
     SwitchGear Promoter luciferase reporter plasmids for HK2
     ThermoFisher Antibody for HK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HK2
     Browse compounds at ApexBio
     Addgene plasmids for HK2
      Search eBioscience for proteins for HK2
      Search eBioscience for elisas for HK2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HK2
     antibodies-online antibodies for HK2 (99 products)
     antibodies-online kits for HK2 (23 products)
     antibodies-online peptides for HK2
     antibodies-online proteins for HK2 (24 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HK2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4