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Aliases for HJURP Gene

Aliases for HJURP Gene

  • Holliday Junction Recognition Protein 2 3
  • Fetal Liver-Expressing Gene 1 Protein 3 4
  • 14-3-3-Associated AKT Substrate 3 4
  • Up-Regulated In Lung Cancer 9 3 4
  • FAKTS 3 4
  • URLC9 3 4
  • Fetal Liver Expressing Gene 1 3
  • HFLEG1 3
  • FLEG1 4

External Ids for HJURP Gene

Previous GeneCards Identifiers for HJURP Gene

  • GC02M234412
  • GC02M234742
  • GC02M226545

Summaries for HJURP Gene

GeneCards Summary for HJURP Gene

HJURP (Holliday Junction Recognition Protein) is a Protein Coding gene. Diseases associated with HJURP include lung cancer. Among its related pathways are Cell Cycle, Mitotic and Packaging Of Telomere Ends. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot for HJURP Gene

  • Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HJURP Gene

Genomics for HJURP Gene

Regulatory Elements for HJURP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HJURP Gene

Start:
233,833,416 bp from pter
End:
233,854,566 bp from pter
Size:
21,151 bases
Orientation:
Minus strand

Genomic View for HJURP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HJURP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HJURP Gene

Proteins for HJURP Gene

  • Protein details for HJURP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCD3-HJURP_HUMAN
    Recommended name:
    Holliday junction recognition protein
    Protein Accession:
    Q8NCD3
    Secondary Accessions:
    • A8IRH5
    • B4DWR0
    • B4DZV4
    • Q9BUT2
    • Q9NSL8

    Protein attributes for HJURP Gene

    Size:
    748 amino acids
    Molecular mass:
    83539 Da
    Quaternary structure:
    • Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN.
    SequenceCaution:
    • Sequence=CAB82391.2; Type=Erroneous termination; Positions=437; Note=Translated as Arg.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HJURP Gene

    Alternative splice isoforms for HJURP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HJURP Gene

Proteomics data for HJURP Gene at MOPED

Post-translational modifications for HJURP Gene

  • Ubiquitination at Lys21, Lys39, Lys278, Lys286, Lys408, Lys506, and Lys648
  • Modification sites at PhosphoSitePlus

Other Protein References for HJURP Gene

No data available for DME Specific Peptides for HJURP Gene

Domains for HJURP Gene

Protein Domains for HJURP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HJURP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HJURP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HJURP Gene

Function for HJURP Gene

Molecular function for HJURP Gene

UniProtKB/Swiss-Prot Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

Gene Ontology (GO) - Molecular Function for HJURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 19410544
GO:0042393 histone binding IPI 19410544
GO:0042802 identical protein binding IPI 23771058
genes like me logo Genes that share ontologies with HJURP: view
genes like me logo Genes that share phenotypes with HJURP: view

Animal Model Products

CRISPR Products

miRNA for HJURP Gene

miRTarBase miRNAs that target HJURP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HJURP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HJURP Gene

Localization for HJURP Gene

Subcellular locations from UniProtKB/Swiss-Prot for HJURP Gene

Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HJURP Gene COMPARTMENTS Subcellular localization image for HJURP gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for HJURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 19410544
GO:0000777 condensed chromosome kinetochore IDA 19410545
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with HJURP: view

Pathways for HJURP Gene

genes like me logo Genes that share pathways with HJURP: view

Gene Ontology (GO) - Biological Process for HJURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IMP 19410544
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0043254 regulation of protein complex assembly IDA 21478274
genes like me logo Genes that share ontologies with HJURP: view

Transcripts for HJURP Gene

Unigene Clusters for HJURP Gene

Holliday junction recognition protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HJURP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HJURP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1:
SP2:
SP3: -
SP4: -

Relevant External Links for HJURP Gene

GeneLoc Exon Structure for
HJURP
ECgene alternative splicing isoforms for
HJURP

Expression for HJURP Gene

mRNA expression in normal human tissues for HJURP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HJURP Gene

This gene is overexpressed in Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HJURP Gene

SOURCE GeneReport for Unigene cluster for HJURP Gene Hs.532968

mRNA Expression by UniProt/SwissProt for HJURP Gene

Q8NCD3-HJURP_HUMAN
Tissue specificity: According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.
genes like me logo Genes that share expressions with HJURP: view

In Situ Assay Products

Orthologs for HJURP Gene

This gene was present in the common ancestor of mammals.

Orthologs for HJURP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HJURP 35
  • 98.16 (n)
  • 96.24 (a)
HJURP 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HJURP 35
  • 70.5 (n)
  • 56.9 (a)
HJURP 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HJURP 35
  • 71.09 (n)
  • 54.66 (a)
HJURP 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hjurp 35
  • 64.17 (n)
  • 47.66 (a)
Hjurp 16
Hjurp 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hjurp 35
  • 63.76 (n)
  • 48.21 (a)
Species with no ortholog for HJURP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HJURP Gene

ENSEMBL:
Gene Tree for HJURP (if available)
TreeFam:
Gene Tree for HJURP (if available)

Paralogs for HJURP Gene

No data available for Paralogs for HJURP Gene

Variants for HJURP Gene

Sequence variations from dbSNP and Humsavar for HJURP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10511 - 233,840,612(+) ACCTC(C/T)CTTCT reference, missense
rs12582 - 233,840,708(+) GTCCG(A/G)AGCCC reference, missense
rs169923 -- 233,838,813(-) TCAGC(C/T)ACATC intron-variant
rs169924 -- 233,840,327(-) TTTCC(C/T)GCAAA intron-variant
rs169925 -- 233,844,362(-) CGCAT(C/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HJURP Gene

Variant ID Type Subtype PubMed ID
dgv4455n71 CNV Loss 21882294
nsv876023 CNV Loss 21882294

Relevant External Links for HJURP Gene

HapMap Linkage Disequilibrium report
HJURP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HJURP Gene

Disorders for HJURP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HJURP Gene including...

Search for HJURP Gene in MalaCards »
genes like me logo Genes that share disorders with HJURP: view

No data available for UniProtKB/Swiss-Prot for HJURP Gene

Publications for HJURP Gene

  1. Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. (PMID: 17823411) Kato T. … Daigo Y. (Cancer Res. 2007) 2 3 4
  2. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4
  3. Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP. (PMID: 19410544) Foltz D.R. … Cleveland D.W. (Cell 2009) 3 4
  4. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PMID: 19410545) Dunleavy E.M. … Almouzni-Pettinotti G. (Cell 2009) 3 4
  5. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. (PMID: 21478274) Hu H. … Xu R.M. (Genes Dev. 2011) 3 4

Products for HJURP Gene

Sources for HJURP Gene

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