Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HJURP Gene

protein-coding   GIFtS: 53
GCID: GC02M234742

Holliday Junction Recognition Protein

  See HJURP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Holliday Junction Recognition Protein1 2     URLC92 3
Fetal Liver-Expressing Gene 1 Protein2 3     Fetal Liver Expressing Gene 12
Up-Regulated In Lung Cancer 92 3     hFLEG12
14-3-3-Associated AKT Substrate2 3     FLEG13
FAKTS2 3     

External Ids:    HGNC: 254441   Entrez Gene: 553552   Ensembl: ENSG000001234857   OMIM: 6126675   UniProtKB: Q8NCD33   

Export aliases for HJURP gene to outside databases

Previous GC identifers: GC02M234412 GC02M226545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for HJURP Gene:
HJURP (Holliday junction recognition protein) is a protein-coding gene. Diseases associated with HJURP include lung cancer. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot: HJURP_HUMAN, Q8NCD3
Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like
variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of
newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization
and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HJURP gene promoter:
         AhR   STAT5B   AML1a   NF-kappaB   Arnt   HNF-1A   HNF-1   FOXO1a   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHJURP promoter sequence
   Search Chromatin IP Primers for HJURP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HJURP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

HJURP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HJURP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M234742:  view genomic region     (about GC identifiers)

Start:
234,742,062 bp from pter      End:
234,763,212 bp from pter
Size:
21,151 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HJURP_HUMAN, Q8NCD3 (See protein sequence)
Recommended Name: Holliday junction recognition protein  
Size: 748 amino acids; 83539 Da
Subunit: Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does
not interact with H3.1- or H3.3-containing nucleosomes. Heterotrimer composed of HJURP, CENPA and histone H4,
where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4.
Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN
Sequence caution: Sequence=CAB82391.2; Type=Erroneous termination; Positions=437; Note=Translated as Arg;
1 PDB 3D structure from and Proteopedia for HJURP:
3R45 (3D)    
Secondary accessions: A8IRH5 B4DWR0 B4DZV4 Q9BUT2 Q9NSL8
Alternative splicing: 3 isoforms:  Q8NCD3-1   Q8NCD3-2   Q8NCD3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HJURP: NX_Q8NCD3

Explore proteomics data for HJURP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21, Lys39, Lys278, Lys286, Lys408, Lys506, Lys648
  • Modification sites at PhosphoSitePlus

  • See HJURP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269891.1  NP_001269892.1  NP_060880.3  

    ENSEMBL proteins: 
     ENSP00000395207   ENSP00000414109   ENSP00000393253   ENSP00000414051   ENSP00000403668  
     ENSP00000407208   ENSP00000401944  
    Reactome Protein details: Q8NCD3

    HJURP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HJURP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HJURP
    GenScript Custom Purified and Recombinant Proteins Services for HJURP
    Novus Biologicals HJURP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HJURP

     
    Search eBioscience for Proteins for HJURP 

     
    antibodies-online proteins for HJURP 

     
    antibodies-online peptides for HJURP

    HJURP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HJURP
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HJURP
    OriGene Custom Antibody Services for HJURP
    Novus Biologicals HJURP Antibodies
    Abcam antibodies for HJURP
    Cloud-Clone Corp. Antibodies for HJURP
    Search ThermoFisher Antibodies for HJURP
    antibodies-online antibodies for HJURP (12 products) 

    HJURP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HJURP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HJURP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HJURP
    Cloud-Clone Corp. CLIAs for HJURP
    Search eBioscience for ELISAs for HJURP 
    antibodies-online kits for HJURP (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR022102 HJURP_C
     IPR018465 Centromere_Scm3_N
     IPR021052 HJURP

    Graphical View of Domain Structure for InterPro Entry Q8NCD3

    ProtoNet protein and cluster: Q8NCD3


    Find genes that share domains with HJURP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HJURP_HUMAN, Q8NCD3
    Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like
    variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of
    newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization
    and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI19410544
    GO:0042393histone binding IPI19410544
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with HJURP           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for HJURP:
     G0/1 arrest  Increased G1 DNA content  Increased cell size  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HJURP

    miRNA
    Products:
        
    miRTarBase miRNAs that target HJURP:
    hsa-mir-215-5p (MIRT024443), hsa-mir-671-5p (MIRT039300), hsa-mir-192-5p (MIRT026468)

    Block miRNA regulation of human, mouse, rat HJURP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HJURP
    SwitchGear 3'UTR luciferase reporter plasmidHJURP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HJURP
    Predesigned siRNA for gene silencing in human, mouse, rat HJURP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HJURP

    Clone
    Products:
         
    OriGene clones in human, mouse for HJURP (see all 8)
    OriGene ORF clones in mouse, rat for HJURP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HJURP (NM_018410)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HJURP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HJURP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HJURP
    Browse ESI BIO Cell Lines and PureStem Progenitors for HJURP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HJURP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HJURP_HUMAN, Q8NCD3: Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late
    telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus
    site being often related to storage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA19410544
    GO:0000777condensed chromosome kinetochore IDA19410545
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with HJURP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HJURP About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Chromosome Maintenance0.62
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Nucleosome assembly0.59
    2Cell Cycle, Mitotic
    Cell Cycle0.90


    Find genes that share SuperPaths with HJURP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HJURP
        Deposition of new CENPA-containing nucleosomes at the centromere


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HJURP
    Interactions:

        Search GeneGlobe Interaction Network for HJURP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HJURP (Q8NCD31, 2, 3 ENSP000004141094) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628053, ENSP000003665814I2D: score=1 STRING: ENSP00000366581
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly TAS--
    GO:0007049cell cycle IEA--
    GO:0007059chromosome segregation IMP19410544
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--
    GO:0043254regulation of protein complex assembly IDA--

    Find genes that share ontologies with HJURP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HJURP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HJURP gene (3 alternative transcripts): 
    NM_001282962.1  NM_001282963.1  NM_018410.4  

    Unigene Cluster for HJURP:

    Holliday junction recognition protein
    Hs.532968  [show with all ESTs]
    Unigene Representative Sequence: NM_018410
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433484 ENST00000411486(uc002vvg.3 uc010znd.2 uc010zne.2)
    ENST00000414924 ENST00000454020 ENST00000434039 ENST00000453122 ENST00000373395
    ENST00000432087 ENST00000441687
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HJURP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HJURP
    SwitchGear 3'UTR luciferase reporter plasmidHJURP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HJURP
    Predesigned siRNA for gene silencing in human, mouse, rat HJURP
    Clone
    Products:
         
    OriGene clones in human, mouse for HJURP (see all 8)
    OriGene ORF clones in mouse, rat for HJURP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HJURP (NM_018410)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HJURP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HJURP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HJURP
    OriGene qSTAR qPCR primer pairs in human, mouse for HJURP
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HJURP
      QuantiTect SYBR Green Assays in human, mouse, rat HJURP
      QuantiFast Probe-based Assays in human, mouse, rat HJURP

    Additional mRNA sequence: 

    AB101211.1 AB162218.1 AK074809.1 AK301643.1 AK303109.1 AL162048.1 BC001940.1 FJ423742.1 
    FJ423746.1 

    7 DOTS entries:

    DT.441770  DT.100782013  DT.100782008  DT.100782014  DT.95307431  DT.121026145  DT.121026143 

    Selected AceView cDNA sequences (see all 147):

    AL547061 BM978336 AA905665 BX385854 BE294545 BU166584 BM475244 AA563628 
    AA779101 CR594599 AA577188 AL162048 CA441903 AA714213 BE253976 BQ017723 
    AA425243 AI857924 CR621677 AW247902 CB143805 BQ927592 BE256060 BM819254 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HJURP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                                                        
    SP2:                                                                        
    SP3:                    -                                                   
    SP4:                                      -                                 


    ECgene alternative splicing isoforms for HJURP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HJURP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGAAAAAT
    HJURP Expression
    About this image


    HJURP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    HJURP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HJURP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532968

    UniProtKB/Swiss-Prot: HJURP_HUMAN, Q8NCD3
    Tissue specificity: According to PubMed:17256767, highly expressed in the thymus with lower levels in the
    placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in
    testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung
    cancer samples, compared with normal lung

        Custom PCR Arrays for HJURP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HJURP
    OriGene qSTAR qPCR primer pairs in human, mouse for HJURP
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HJURP
    QuantiTect SYBR Green Assays in human, mouse, rat HJURP
    QuantiFast Probe-based Assays in human, mouse, rat HJURP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HJURP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for HJURP gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hjurp1 , 5 Holliday junction recognition protein1, 5 64.17(n)1
    47.66(a)1
      1 (44.57 cM)5
    3812801  NM_198652.21  NP_941054.21 
     882624715 


    ENSEMBL Gene Tree for HJURP (if available)
    TreeFam Gene Tree for HJURP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HJURP (see all 597)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440335281,2
    --234745072(+) TAAACG/TTCTAG 1 -- int10--------
    rs1411148011,2
    C--234745169(+) GCACG-/CACACAC 1 -- int10--------
    rs2006597571,2
    C--234745338(-) AGTTTG/TGGTTT 1 -- int10--------
    rs2135511,2
    C,F,A,H--234745389(-) ATACAT/CTGGTG 1 -- int128Minor allele frequency- C:0.25EA NS NA WA 3368
    rs1146230411,2
    C--234745473(+) ATGAGA/GAGTCA 1 -- int10--------
    rs1126716791,2
    C,F--234745651(+) ACACAC/TGGCTG 1 -- ut312Minor allele frequency- T:0.08CSA WA 120
    rs1879702061,2
    --234745761(+) ACCCCA/GTCTCT 1 -- ut310--------
    rs2135521,2
    C,F,A,H--234745789(-) ACGCCC/TGGCTA 1 -- ut319Minor allele frequency- T:0.18NA WA CSA 17
    rs1501703541,2
    C--234745793(+) CAGGCA/GTGGTG 1 -- ut310--------
    rs1116883901,2
    C,F--234745802(+) TGGCGC/TGCGCC 1 -- ut311Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for HJURP (234742062 - 234763212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HJURP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876023CNV Loss21882294
    dgv4455n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HJURP
    DNA2.0 Custom Variant and Variant Library Synthesis for HJURP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612667    OMIM disorders: --

    1 disease for HJURP:    
    About MalaCards
    lung cancer


    Find genes that share disorders with HJURP           About GenesLikeMe


    Export disorders for HJURP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HJURP gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with HJURP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. (PubMed id 17823411)1, 2, 3 Kato T.... Daigo Y. (Cancer Res. 2007)
    2. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. (PubMed id 21478274)1, 2 Hu H.... Xu R.M. (Genes Dev. 2011)
    3. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PubMed id 19410545)1, 2 Dunleavy E.M.... Almouzni-Pettinotti G. (Cell 2009)
    4. Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP. (PubMed id 19410544)1, 2 Foltz D.R.... Cleveland D.W. (Cell 2009)
    5. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    6. Acidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres. (PubMed id 23184928)1 Jaramillo-Lambert A....Zhu W. (J. Biol. Chem. 2013)
    7. Modulation of HJURP (Holliday Junction-Recognizing Protein) levels is correlated with glioblastoma cells survival. (PubMed id 23638004)1 Valente V....Carlotti C.G. (PLoS ONE 2013)
    8. Identification of functionally conserved regions in the structure of the chaperone/CenH3/H4 complex. (PubMed id 23178171)1 Hong J....Bai Y. (J. Mol. Biol. 2013)
    9. Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition. (PubMed id 23771058)1 ZasadziA8ska E....Foltz D.R. (EMBO J. 2013)
    10. HJURP regulates cellular senescence in human fibroblasts and endothelial cells via a p53-dependent pathway. (PubMed id 23292286)1 Heo J.I....Kim J.R. (J. Gerontol. A Biol. Sci. Med. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55355 HGNC: 25444 AceView: DKFZp762E1312 Ensembl:ENSG00000123485 euGenes: HUgn55355
    ECgene: HJURP H-InvDB: HJURP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HJURP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HJURP gene:
    Search GeneIP for patents involving HJURP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HJURP
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HJURP   OriGene RNAi products in human, mouse, rat for HJURP  
     OriGene qPCR primer pairs and template standards for HJURP   OriGene Protein Over-expression Lysate for HJURP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HJURP  
     OriGene qSTAR qPCR primer pairs in human, mouse for HJURP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HJURP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HJURP   OriGene Custom Protein Services for HJURP  

     
     
     Block miRNA regulation of human, mouse, rat HJURP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HJURP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HJURP Predesigned siRNA for gene silencing in human, mouse, rat HJURP
     QuantiFast Probe-based Assays in human, mouse, rat HJURP QuantiTect SYBR Green Assays in human, mouse, rat HJURP
     Custom PCR Arrays for HJURP Search Chromatin IP Primers for HJURP
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HJURP  Search GeneGlobe Interaction Network for HJURP
     Regulatory tfbs in HJURP promoter
     GenScript Custom Purified and Recombinant Proteins Services for HJURP GenScript cDNA clones with any tag delivered in your preferred vector for HJURP
     GenScript Custom Assay Services for HJURP GenScript Custom overexpressing Cell Line Services for HJURP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HJURP
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HJURP antibodies
     HJURP lysates
     Antibodies for HJURP
     See all of Abcam's Antibodies, Kits and Proteins for HJURP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HJURP
     Antibodies for HJURP
     ELISAs for HJURP
     CLIAs for HJURP



     Browse ESI BIO Cell Lines and PureStem Progenitors for HJURP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HJURP
     SwitchGear 3'UTR luciferase reporter plasmids for HJURP
     SwitchGear Promoter luciferase reporter plasmids for HJURP
     Search ThermoFisher Antibodies for HJURP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HJURP
     Browse compounds at ApexBio
     Search Addgene for plasmids for HJURP
      Search eBioscience for proteins for HJURP
      Search eBioscience for elisas for HJURP
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HJURP
     antibodies-online antibodies for HJURP (12 products)
     antibodies-online kits for HJURP (4 products)
     antibodies-online peptides for HJURP
     antibodies-online proteins for HJURP
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HJURP gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4