Aliases for HJURP Gene
Aliases for HJURP Gene
External Ids for HJURP Gene
- HGNC: 25444
- Entrez Gene: 55355
- Ensembl: ENSG00000123485
- OMIM: 612667
- UniProtKB: Q8NCD3
Previous GeneCards Identifiers for HJURP Gene
- GC02M234412
- GC02M234742
- GC02M226545
Summaries for HJURP Gene
GeneCards Summary for HJURP Gene
HJURP (Holliday Junction Recognition Protein) is a Protein Coding gene. Diseases associated with HJURP include Fibrillary Astrocytoma. Among its related pathways are Chromosome Maintenance and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding and histone binding.
UniProtKB/Swiss-Prot for HJURP Gene
-
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HJURP Gene
Genomics for HJURP Gene
Regulatory Elements for HJURP Gene
Enhancers for HJURP Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G233851 | 1.1 | ENCODE | 9.6 | +0.8 | 789 | 3.9 | PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS | MSL3P1 HJURP PIR47187 |
| GH02G233857 | 0.9 | ENCODE | 9.6 | -3.2 | -3242 | 0.7 | HDAC1 PKNOX1 FOXA2 ATF1 SIN3A RAD21 TCF12 GATA2 ZNF143 CEBPB | MSL3P1 HJURP ENSG00000279809 |
| GH02G233867 | 0.9 | ENCODE | 9 | -13.8 | -13826 | 1.1 | HDAC1 ATF1 RB1 CREB3L1 ZNF76 SIN3A ZNF2 ZNF766 EGR1 RCOR1 | MSL3P1 TRPM8 UGT1A4 HJURP ENSG00000279809 |
| GH02G233832 | 0.9 | Ensembl ENCODE | 8.6 | +21.8 | 21768 | 0.8 | CTCF ZNF654 MAX SIN3A NR3C1 RAD21 JUND POLR2A SMC3 HNRNPL | MROH2A HJURP MSL3P1 PIR47187 |
| GH02G234572 | 0.4 | ENCODE | 7 | -717.6 | -717646 | 0.2 | MNT SPI1 | HJURP LOC105373936 ARL4C |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HJURP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HJURP gene promoter:
Regulatory Element Products
Genomic Location for HJURP Gene
- Chromosome:
- 2
- Start:
- 233,833,416 bp from pter
- End:
- 233,854,566 bp from pter
- Size:
- 21,151 bases
- Orientation:
- Minus strand
Genomic View for HJURP Gene
Genes around HJURP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.1 by Ensembl
- 2q37.1 by Entrez Gene
- 2q37.1 by HGNC
HJURP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HJURP Gene
Proteins for HJURP Gene
-
Protein details for HJURP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NCD3-HJURP_HUMAN
- Recommended name:
- Holliday junction recognition protein
- Protein Accession:
- Q8NCD3
- A8IRH5
- B4DWR0
- B4DZV4
- Q9BUT2
- Q9NSL8
Protein attributes for HJURP Gene
- Size:
- 748 amino acids
- Molecular mass:
- 83539 Da
- Quaternary structure:
-
- Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes (PubMed:16622419, PubMed:19410544, PubMed:19410545). Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4 (PubMed:21478274). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Interacts with 14-3-3 family members in a phosphorylation-dependent manner (PubMed:17256767). Interacts with MSH5 and NBN (PubMed:17823411).
- SequenceCaution:
-
- Sequence=CAB82391.2; Type=Erroneous termination; Positions=437; Note=Translated as Arg.; Evidence={ECO:0000305};
Protein Expression for HJURP Gene
Post-translational modifications for HJURP Gene
Other Protein References for HJURP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HJURP
- Cell Signaling Technology (CST) Antibodies for HJURP (HJURP)
-
Custom Antibody ServicesOriGene Antibodies for HJURP
- Novus Biologicals Antibodies for HJURP
- Invitrogen Antibodies for HJURP
- antibodies-online Antibodies for HJURP: See all 29
- Search GeneTex for Antibodies for HJURP
Protein Products
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- antibodies-online Proteins for HJURP: See all 3
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- Search GeneTex for Proteins for HJURP
Assay Products
No data available for DME Specific Peptides for HJURP Gene
Domains & Families for HJURP Gene
Protein Domains for HJURP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HJURP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HJURP Gene
Function for HJURP Gene
Molecular function for HJURP Gene
- UniProtKB/Swiss-Prot Function:
- Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 19410544 |
| GO:0042393 | histone binding | IPI | 19410544 |
| GO:0042802 | identical protein binding | IPI | 23771058 |
Phenotypes for HJURP Gene
- GenomeRNAi human phenotypes for HJURP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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ViGene Biosciences lentiviral particle packaged cDNA for HJURP gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HJURP
-
Santa Cruz Biotechnology (SCBT) CRISPR for HJURP
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miRNA for HJURP Gene
- miRTarBase miRNAs that target HJURP
-
- hsa-mir-215-5p (MIRT024443)
- hsa-mir-192-5p (MIRT026468)
- hsa-mir-671-5p (MIRT039300)
- hsa-mir-218-5p (MIRT440500)
- hsa-mir-665 (MIRT691126)
- hsa-mir-6771-5p (MIRT691127)
- hsa-mir-7977 (MIRT691128)
- hsa-mir-4634 (MIRT691129)
- hsa-mir-7160-5p (MIRT691130)
- hsa-mir-4783-5p (MIRT691131)
- hsa-mir-6720-3p (MIRT691132)
- hsa-mir-298 (MIRT691133)
- hsa-mir-6884-5p (MIRT691134)
- hsa-mir-485-5p (MIRT691135)
- hsa-mir-1827 (MIRT691136)
- hsa-mir-4649-3p (MIRT691137)
- hsa-mir-6746-5p (MIRT691138)
- hsa-mir-1247-3p (MIRT691139)
- hsa-mir-5690 (MIRT691140)
- hsa-mir-4478 (MIRT691141)
- hsa-mir-4419b (MIRT691142)
- hsa-mir-3929 (MIRT691143)
- hsa-mir-6511a-5p (MIRT691144)
- hsa-mir-1910-3p (MIRT691145)
miRNA Products
- Search ViGene Biosciences for HJURP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HJURP
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Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HJURP Gene
Localization for HJURP Gene
Subcellular locations from UniProtKB/Swiss-Prot for HJURP Gene
- Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IDA | 19410544 |
| GO:0000777 | condensed chromosome kinetochore | IDA | 19410545 |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HJURP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromosome Maintenance | ||
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | DNA Damage | ||
| 4 | Cell Cycle, Mitotic |
.83
|
|
Pathways by source for HJURP Gene
2 Cell Signaling Technology pathways for HJURP Gene
4 Reactome pathways for HJURP Gene
Interacting Proteins for HJURP Gene
Selected Interacting proteins:
ENSP00000414109
Q8NCD3-HJURP_HUMAN
for HJURP Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007059 | chromosome segregation | IMP | 19410544 |
| GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
| GO:0043254 | regulation of protein complex assembly | IDA | 21478274 |
| GO:0051101 | regulation of DNA binding | IDA | 21478274 |
No data available for SIGNOR curated interactions for HJURP Gene
Transcripts for HJURP Gene
mRNA/cDNA for HJURP Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (147) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HJURP Gene
CRISPR Products
-
OriGene CRISPR knockouts for HJURP
-
Santa Cruz Biotechnology (SCBT) CRISPR for HJURP
- GenScript: Design CRISPR guide RNA sequences for HJURP
miRNA Products
- Search ViGene Biosciences for HJURP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HJURP
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-
ViGene Biosciences ready-to-package AAV shRNAs for HJURP gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - |
Expression for HJURP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HJURP Gene
This gene is overexpressed in Testis (x6.3).
This gene is overexpressed in Breast (38.4) and NK cells (30.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HJURP Gene
NURSA nuclear receptor signaling pathways regulating expression of HJURP Gene:
HJURPSOURCE GeneReport for Unigene cluster for HJURP Gene:
Hs.532968mRNA Expression by UniProt/SwissProt for HJURP Gene:
Q8NCD3-HJURP_HUMAN
Tissue specificity:
According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.
Primer Products
-
OriGene qPCR primer pairs and template standards for HJURP
-
OriGene qPCR primer pairs for HJURP
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HJURP Gene
Orthologs for HJURP Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HJURP 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HJURP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HJURP 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hjurp 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hjurp 34 |
|
- Species where no ortholog for HJURP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HJURP Gene
No data available for Paralogs for HJURP Gene
Variants for HJURP Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000058633 | -- | 233,851,874(+) | TCATA(C/T)AGGTT | intron-variant | |
| rs1000369947 | -- | 233,844,632(+) | ACCCA(A/G)TAGAT | intron-variant | |
| rs1000495596 | -- | 233,838,301(+) | GGCCA(C/G/T)CAAGG | intron-variant | |
| rs1000624423 | -- | 233,845,265(+) | TCCTG(C/T)CTTAG | intron-variant | |
| rs1000656854 | -- | 233,845,619(+) | CAAAT(A/G)CTCTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1008316 | CNV | gain | 25217958 |
| nsv1013712 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.06;
87.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HJURP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HJURP Gene
Disorders for HJURP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fibrillary astrocytoma |
|
|
Search HJURP in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HJURP
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HJURP
No data available for UniProtKB/Swiss-Prot and Genatlas for HJURP Gene
Publications for HJURP Gene
- Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. (PMID: 17823411) Kato T. … Daigo Y. (Cancer Res. 2007) 2 3 4 64
- Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. (PMID: 21478274) Hu H. … Xu R.M. (Genes Dev. 2011) 3 4 64
- Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP. (PMID: 19410544) Foltz D.R. … Cleveland D.W. (Cell 2009) 3 4 64
- HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PMID: 19410545) Dunleavy E.M. … Almouzni-Pettinotti G. (Cell 2009) 3 4 64
- The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4 64
Products for HJURP Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HJURP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
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