Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HJURP Gene

protein-coding GIFtS: 49
GCID: GC02M234742

Holliday junction recognition protein

Explore 2 diseases affiliated with
HJURP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Holliday Junction Recognition Protein¹ ²		Up-Regulated In Lung Cancer 9² ³
FAKTS¹ ² ³		14-3-3-Associated AKT Substrate² ³
URLC9¹ ² ³		DKFZp762E1312¹
HFLEG1¹		Fetal Liver Expressing Gene 1²
Fetal Liver-Expressing Gene 1 Protein² ³		FLEG1³

External Ids:	HGNC: 25444¹	Entrez Gene: 55355²	Ensembl: ENSG00000123485⁷	OMIM: 612667⁵	UniProtKB: Q8NCD3³

Export aliases for HJURP gene to outside databases

Previous GC identifers: GC02M234412 GC02M226545

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HJURP_HUMAN, Q8NCD3

Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant

CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly

synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents

premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005120.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HJURP gene promoter:
AhR STAT5B AML1a NF-kappaB Arnt HNF-1A HNF-1 FOXO1a NF-kappaB1 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HJURP promoter sequence

Search SABiosciences Chromatin IP Primers for HJURP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HJURP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

HJURP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HJURP gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M234742: view genomic region (about GC identifiers)

Start:	234,742,062 bp from pter	End:	234,763,212 bp from pter
Size:	21,151 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HJURP_HUMAN, Q8NCD3 (See protein sequence)

Recommended Name: Holliday junction recognition protein

Size: 748 amino acids; 83539 Da

Subunit: Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not

interact with H3.1- or H3.3-containing nucleosomes. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP

interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Interacts with

14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN

Subcellular location: Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase

and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often

related to storage

Sequence caution: Sequence=CAB82391.2; Type=Erroneous termination; Positions=437; Note=Translated as Arg;

1 PDB 3D structure from and Proteopedia for HJURP:

3R45 (3D)

Secondary accessions: A8IRH5 B4DWR0 B4DZV4 Q9BUT2 Q9NSL8

Alternative splicing: 3 isoforms: Q8NCD3-1 Q8NCD3-2 Q8NCD3-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HJURP: NX_Q8NCD3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NCD3

HJURP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060880.3

ENSEMBL proteins:

ENSP00000395207 ENSP00000414109 ENSP00000393253 ENSP00000414051 ENSP00000403668

ENSP00000407208 ENSP00000401944

Reactome Protein details: Q8NCD3
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HJURP OriGene Custom Protein Services for HJURP
	GenScript Custom Purified and Recombinant Proteins Services for HJURP
	Novus Biologicals HJURP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HJURP

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	IDA	19410544
GO:0000777	condensed chromosome kinetochore	IDA	19410545
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	nucleolus	IDA	--

HJURP for ontologies About GeneDecksing

HJURP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HJURP
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HJURP
	GenScript Custom Superior Antibodies Services for HJURP
	Novus Biologicals HJURP Antibodies
	Search for Antibodies for HJURP at Abcam
	Uscn Antibodies for HJURP
	Search ThermoFisher Antibodies for HJURP

Assay Products for HJURP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HJURP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HJURP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HJURP for domains About GeneDecksing

3 InterPro domains/families:

IPR022102 HJURP_C

IPR018465 Centromere_Scm3_N

IPR021052 HJURP

Graphical View of Domain Structure for InterPro Entry Q8NCD3

ProtoNet protein and cluster: Q8NCD3

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HJURP_HUMAN, Q8NCD3

Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant

CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly

synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents

premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions

miRNA Products:		OriGene 3'-UTR Clone: HJURP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HJURP
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HJURP
		SwitchGear 3'UTR luciferase reporter plasmid: HJURP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HJURP OriGene shRNA RFP: HJURP OriGene siRNA: HJURP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HJURP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HJURP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HJURP (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HJURP (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HJURP (NM_018410)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HJURP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HJURP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HJURP
		Search LifeMap BioReagents cell lines for HJURP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HJURP

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0042393	histone binding	IPI	19410545

HJURP for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for HJURP:

G0/1 arrest	Increased G1 DNA content	Increased cell size	Increased gamma-H2AX phosphory
Increased number of mitotic ce

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

RSF Complex Binds the Centromere.

	RSF Complex Binds the Centromere.	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere	1.00
	Nucleosome assembly	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere.	0.96

Cell Cycle

Cell Cycle

1.00

Meiotic Synapsis

Chromosome Maintenance

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for HJURP (see all 6)

	Deposition of New CENPA-containing Nucleosomes at the Centromere.
	Nucleosome assembly
	Cell Cycle
	RSF Complex Binds the Centromere.
	Deposition of New CENPA-containing Nucleosomes at the Centromere

HJURP for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HJURP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for HJURP (Q8NCD3^{1, 2, 3} ENSP00000414109⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4B	P62805³, ENSP00000366581⁴	I2D: score=1 STRING: ENSP00000366581
HIST4H4	P62805³, ENSP00000350767⁴	I2D: score=1 STRING: ENSP00000350767
HIST1H4L	P62805³, ENSP00000348258⁴	I2D: score=1 STRING: ENSP00000348258
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=1 STRING: ENSP00000352980
HIST1H4C	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	TAS	--
GO:0007049	cell cycle	IEA	--
GO:0007059	chromosome segregation	IMP	19410544
GO:0034080	CENP-A containing nucleosome assembly at centromere	TAS	--
GO:0043254	regulation of protein complex assembly	IDA	--

HJURP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HJURP
Search CenterWatch for drugs/clinical trials and news about HJURP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HJURP gene:

NM_018410.3

Unigene Cluster for HJURP:

Holliday junction recognition protein

Hs.532968 [show with all ESTs]

Unigene Representative Sequence: NM_018410

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000433484 ENST00000411486(uc002vvg.3 uc010znd.2 uc010zne.2)

ENST00000414924 ENST00000454020 ENST00000434039 ENST00000453122 ENST00000373395

ENST00000432087 ENST00000441687

miRNA Products:		OriGene 3'-UTR Clone: HJURP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HJURP
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HJURP
		SwitchGear 3'UTR luciferase reporter plasmid: HJURP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HJURP OriGene shRNA RFP: HJURP OriGene siRNA: HJURP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HJURP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HJURP (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HJURP (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HJURP (NM_018410)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HJURP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HJURP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HJURP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat HJURP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HJURP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HJURP

Additional cDNA sequence:

AB101211.1 AB162218.1 AK074809.1 AK301643.1 AK303109.1 AL162048.1 BC001940.1 FJ423742.1

FJ423746.1

7 DOTS entries:

DT.441770 DT.100782013 DT.100782008 DT.100782014 DT.95307431 DT.121026145 DT.121026143

24/147 AceView cDNA sequences (see all 147):

CR594599 BM978336 BM475244 AA563628 AA779101 CA441903 AL162048 BE253976

BQ017723 BQ927592 AI857924 AW247902 CB143805 AA714213 CR621677 AA425243

AA577188 BU166584 BE294545 BX385854 AL547061 AA905665 BI766383 BM819254

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HJURP About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9
SP1:
SP2:
SP3:							-
SP4:													-

ECgene alternative splicing isoforms for HJURP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HJURP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAGAAAAAT

About this image

HJURP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HJURP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HJURP

SOURCE GeneReport for Unigene cluster: Hs.532968

UniProtKB/Swiss-Prot: HJURP_HUMAN, Q8NCD3

Tissue specificity: According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta,

small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a

relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared

with normal lung

SABiosciences Custom PCR Arrays for HJURP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HJURP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat HJURP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HJURP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HJURP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HJURP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HJURP gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hjurp^{1 , 5}	Holliday junction recognition protein^{1, 5}	63.28(n)¹ 46(a)¹		1 (44.57 cM)⁵ 381280¹ NM_198652.2¹ NP_941054.2¹ 88262471⁵
chicken (Gallus gallus)	Aves	LOC418413⁶	hypothetical protein LOC418413	22(a)	1 ↔ 1	1(90952631-90966985)

ENSEMBL Gene Tree for HJURP (if available)
TreeFam Gene Tree for HJURP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144033528^1,2		--	234745072(+)	`TAAACG/TTCTAG`	1	--	int¹		0	--	--	--	--
rs141114801^1,2	C,	--	234745169(+)	`GCACG-/CACACAC`	1	--	int¹		0	--	--	--	--
rs200659757^1,2	C	--	234745338(-)	`AGTTTG/TGGTTT`	1	--	int¹		0	--	--	--	--
rs213551^1,2	C,F,A,H,	--	234745389(-)	`ATACAT/CTGGTG`	1	--	int¹		28		EA NS NA WA	3368
rs114623041^1,2	C,	--	234745473(+)	`ATGAGA/GAGTCA`	1	--	int¹		0	--	--	--	--
rs112671679^1,2		--	234745651(+)	`ACACAC/TGGCTG`	1	--	ut3¹		2		CSA WA	120
rs187970206^1,2		--	234745761(+)	`ACCCCA/GTCTCT`	1	--	ut3¹		0	--	--	--	--
rs213552^1,2	C,F,A,H,	--	234745789(-)	`ACGCCC/TGGCTA`	1	--	ut3¹		9		NA WA CSA	17
rs150170354^1,2		--	234745793(+)	`CAGGCA/GTGGTG`	1	--	ut3¹		0	--	--	--	--
rs111688390^1,2		--	234745802(+)	`TGGCGC/TGCGCC`	1	--	ut3¹		1		CSA	2

HapMap Linkage Disequilibrium report for HJURP (234742062 - 234763212 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HJURP: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HJURP

DNA2.0 Custom Variant and Variant Library Synthesis for HJURP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HJURP for disorders           About GeneDecksing

OMIM gene information: 612667    OMIM disorders: --

2 diseases for HJURP:    About MalaCards

lung cancer breast cancer

Export disorders for HJURP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HJURP gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with HJURP)

Utopia: connect your pdf to the dynamic
world of online information

Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. (PubMed id 17823411)^{1, 2, 3} Kato T.... Daigo Y. (2007)
Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. (PubMed id 21478274)^{1, 2} Hu H.... Xu R.M. (2011)
Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP. (PubMed id 19410544)^{1, 2} Foltz D.R.... Cleveland D.W. (2009)
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PubMed id 19410545)^{1, 2} Dunleavy E.M....Almouzni-Pettinotti G. (2009)
The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)^{1, 2} Foltz D.R....Cleveland D.W. (2006)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
HJURP uses distinct CENP-A surfaces to recognize and t o stabilize CENP-A/histone H4 for centromere assembly. (PubMed id 22406139)¹ Bassett E.A....Black B.E. (2012)
HJURP is a CENP-A chromatin assembly factor sufficien t to form a functional de novo kinetochore. (PubMed id 21768289)¹ Barnhart M.C....Foltz D.R. (2011)
Xenopus HJURP and condensin II are required for CENP-A assembly. (PubMed id 21321101)¹ Bernad R....Losada A. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55355	HGNC: 25444	AceView: DKFZp762E1312	Ensembl:ENSG00000123485	euGenes: HUgn55355
ECgene: HJURP	H-InvDB: HJURP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HJURP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HJURP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HJURP gene:
Search GeneIP for patents involving HJURP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of HJURP
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HJURP
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HJURP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HJURP
	OriGene Protein Over-expression Lysate for HJURP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HJURP		OriGene 3'-UTR Clone for HJURP
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HJURP		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HJURP
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HJURP		OriGene Custom Protein Services for HJURP
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HJURP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HJURP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HJURP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HJURP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HJURP
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HJURP

	GenScript Custom Purified and Recombinant Proteins Services for HJURP		GenScript cDNA clones with any tag delivered in your preferred vector for HJURP
	GenScript Custom Assay Services for HJURP		GenScript Custom Superior Antibodies Services for HJURP
	GenScript Custom overexpressing Cell Line Services for HJURP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HJURP promoter
	Search Chromatin IP Primers for HJURP
	RT² qPCR Primer Assay in human, mouse / rat HJURP
	Search GNC Networks for HJURP
	SABiosciences Custom PCR Arrays for HJURP

Search Tocris compounds for HJURP

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HJURP antibodies
	HJURP lysates

	Search for Antibodies for HJURP at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HJURP
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HJURP Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HJURP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HJURP

	SwitchGear 3'UTR luciferase reporter plasmids for HJURP
	SwitchGear Promoter luciferase reporter plasmids for HJURP

Search ThermoFisher Antibodies for HJURP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HJURP

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HJURP gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HJURP Gene

Holliday junction recognition protein

Aliases
for HJURP gene

Summaries
for HJURP gene

Genomic Views
for HJURP gene

Proteins
for HJURP gene

Protein Domains /
Families
for HJURP gene

Function
for HJURP gene

Pathways & Interactions
for HJURP gene

Drugs & Compounds
for HJURP gene

Transcripts
for HJURP gene

Expression
for HJURP gene

Orthologs
for HJURP gene

Paralogs
for HJURP gene

Genomic Variants
for HJURP gene

Disorders / Diseases
for HJURP gene

Publications
for HJURP gene

External Searches for HJURP gene

Genome Databases showing HJURP gene

Other Databases showing HJURP gene

Specialized Databases showing HJURP gene

Intellectual Property
for HJURP gene

Products
for HJURP gene

View Random Gene

Advanced Search

Export list of displayed genes

HJURP Gene

Holliday junction recognition protein

Aliasesfor HJURP gene

Summariesfor HJURP gene

Genomic Viewsfor HJURP gene

Proteinsfor HJURP gene

Protein Domains /Familiesfor HJURP gene

Functionfor HJURP gene

Pathways & Interactionsfor HJURP gene

Drugs & Compoundsfor HJURP gene

Transcriptsfor HJURP gene

Expression for HJURP gene

Orthologsfor HJURP gene

Paralogsfor HJURP gene

Genomic Variantsfor HJURP gene

Disorders / Diseasesfor HJURP gene

Publicationsfor HJURP gene

External Searches for HJURP gene

Genome Databases showing HJURP gene

Other Databases showing HJURP gene

Specialized Databases showing HJURP gene

Intellectual Propertyfor HJURP gene

Productsfor HJURP gene

View Random Gene

Aliases
for HJURP gene

Summaries
for HJURP gene

Genomic Views
for HJURP gene

Proteins
for HJURP gene

Protein Domains /
Families
for HJURP gene

Function
for HJURP gene

Pathways & Interactions
for HJURP gene

Drugs & Compounds
for HJURP gene

Transcripts
for HJURP gene

Expression
for HJURP gene

Orthologs
for HJURP gene

Paralogs
for HJURP gene

Genomic Variants
for HJURP gene

Disorders / Diseases
for HJURP gene

Publications
for HJURP gene

Intellectual Property
for HJURP gene

Products
for HJURP gene