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Aliases for HIVEP3 Gene

Aliases for HIVEP3 Gene

  • Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 2 3 5
  • Kappa-B And V(D)J Recombination Signal Sequences-Binding Protein 3 4
  • Human Immunodeficiency Virus Type I Enhancer-Binding Protein 3 2 4
  • Zinc Finger Protein ZAS3 3 4
  • Kappa-Binding Protein 1 3 4
  • KBP-1 3 4
  • KBP1 3 4
  • ZAS3 3 4
  • KRC 3 4
  • Transcription Factor HIVEP3 3
  • Kappabinding Protein-1 2
  • ZAS Family, Member 3 3
  • Schnurri-3 3
  • KIAA1555 4
  • ZNF40C 3
  • SHN3 3

External Ids for HIVEP3 Gene

Previous GeneCards Identifiers for HIVEP3 Gene

  • GC01M042003
  • GC01M040979
  • GC01M041440
  • GC01M041388
  • GC01M041644
  • GC01M041744
  • GC01M040093
  • GC01M041974
  • GC01M041985

Summaries for HIVEP3 Gene

Entrez Gene Summary for HIVEP3 Gene

  • This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for HIVEP3 Gene

HIVEP3 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 3) is a Protein Coding gene. Diseases associated with HIVEP3 include Presbyopia and Eye Accommodation Disease. An important paralog of this gene is HIVEP2.

UniProtKB/Swiss-Prot for HIVEP3 Gene

  • Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.

Gene Wiki entry for HIVEP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIVEP3 Gene

Genomics for HIVEP3 Gene

Regulatory Elements for HIVEP3 Gene

Enhancers for HIVEP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F041894 1.5 FANTOM5 Ensembl ENCODE 9.5 +137.1 137099 9.7 PKNOX1 ATF1 CREB3L1 SIN3A FOS PBX2 SP7 BACH1 ZNF175 ZNF664 ENSG00000235358 GUCA2B ENSG00000230881 LOC100418723 HIVEP3 PIR53563
GH01F041860 1.5 FANTOM5 Ensembl ENCODE 7.2 +173.0 173000 4.7 ATF1 SIN3A GLIS2 GATA2 FOS ZNF592 SREBF1 MBD2 SMARCA4 GLIS1 HIVEP3 PIR53563 GC01M041738
GH01F041867 1.6 FANTOM5 Ensembl ENCODE 6.5 +167.6 167618 1.5 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 GATA2 ZNF143 HIVEP3 PIR53563 GC01M041738
GH01F041889 1.4 FANTOM5 Ensembl ENCODE 6.8 +144.1 144139 3.8 PKNOX1 SIN3A RAD21 RFX5 ZNF143 ZNF362 JUNB REST TBX21 ZSCAN16 GUCA2B HIVEP3 PIR53563
GH01F041869 1.4 Ensembl ENCODE 6.6 +165.7 165739 1.6 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 PPIH HNRNPFP1 ENSG00000213987 FOXJ3 ENSG00000235358 HIVEP3 PIR53563 GC01M041738
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIVEP3 on UCSC Golden Path with GeneCards custom track

Promoters for HIVEP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164932 31 1800 PKNOX1 WRNIP1 ZFP64 SIN3A FEZF1 THRB ZNF48 ZNF2 RAD21 RARA

Genomic Location for HIVEP3 Gene

Chromosome:
1
Start:
41,506,365 bp from pter
End:
42,035,931 bp from pter
Size:
529,567 bases
Orientation:
Minus strand

Genomic View for HIVEP3 Gene

Genes around HIVEP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIVEP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIVEP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIVEP3 Gene

Proteins for HIVEP3 Gene

  • Protein details for HIVEP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1R4-ZEP3_HUMAN
    Recommended name:
    Transcription factor HIVEP3
    Protein Accession:
    Q5T1R4
    Secondary Accessions:
    • A7YY91
    • Q5T1R5
    • Q9BZS0
    • Q9HCL7

    Protein attributes for HIVEP3 Gene

    Size:
    2406 amino acids
    Molecular mass:
    259465 Da
    Quaternary structure:
    • Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 (By similarity).
    SequenceCaution:
    • Sequence=BAB13381.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HIVEP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIVEP3 Gene

Post-translational modifications for HIVEP3 Gene

No data available for DME Specific Peptides for HIVEP3 Gene

Domains & Families for HIVEP3 Gene

Gene Families for HIVEP3 Gene

Protein Domains for HIVEP3 Gene

Suggested Antigen Peptide Sequences for HIVEP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T1R4

UniProtKB/Swiss-Prot:

ZEP3_HUMAN :
  • The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
  • Contains 1 CCHC HIVEP-type zinc finger.
genes like me logo Genes that share domains with HIVEP3: view

Function for HIVEP3 Gene

Molecular function for HIVEP3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
UniProtKB/Swiss-Prot Induction:
By 12-O-tetradecanoylphorbol-13 acetate (TPA).

Gene Ontology (GO) - Molecular Function for HIVEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HIVEP3: view
genes like me logo Genes that share phenotypes with HIVEP3: view

Animal Models for HIVEP3 Gene

MGI Knock Outs for HIVEP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for HIVEP3

miRNA for HIVEP3 Gene

miRTarBase miRNAs that target HIVEP3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIVEP3 Gene

Localization for HIVEP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIVEP3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIVEP3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIVEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HIVEP3: view

Pathways & Interactions for HIVEP3 Gene

SuperPathways for HIVEP3 Gene

No Data Available

Interacting Proteins for HIVEP3 Gene

Selected Interacting proteins: Q5T1R4-ZEP3_HUMAN for HIVEP3 Gene via IID

Gene Ontology (GO) - Biological Process for HIVEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007165 signal transduction IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with HIVEP3: view

No data available for Pathways by source and SIGNOR curated interactions for HIVEP3 Gene

Transcripts for HIVEP3 Gene

Unigene Clusters for HIVEP3 Gene

Human immunodeficiency virus type I enhancer binding protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIVEP3 Gene

No ASD Table

Relevant External Links for HIVEP3 Gene

GeneLoc Exon Structure for
HIVEP3
ECgene alternative splicing isoforms for
HIVEP3

Expression for HIVEP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HIVEP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIVEP3 Gene

This gene is overexpressed in Tlymphocyte (15.1), Monocytes (13.9), Plasma (12.3), Blymphocyte (10.6), and Adipocyte (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIVEP3 Gene



Protein tissue co-expression partners for HIVEP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIVEP3 Gene:

HIVEP3

SOURCE GeneReport for Unigene cluster for HIVEP3 Gene:

Hs.403972
genes like me logo Genes that share expression patterns with HIVEP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIVEP3 Gene

Orthologs for HIVEP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIVEP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIVEP3 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia HIVEP3 34 35
  • 88.28 (n)
cow
(Bos Taurus)
Mammalia HIVEP3 34 35
  • 88.04 (n)
mouse
(Mus musculus)
Mammalia Hivep3 34 16 35
  • 82.84 (n)
rat
(Rattus norvegicus)
Mammalia Hivep3 34
  • 82.62 (n)
oppossum
(Monodelphis domestica)
Mammalia HIVEP3 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves HIVEP3 34 35
  • 71.65 (n)
lizard
(Anolis carolinensis)
Reptilia HIVEP3 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hivep3 34
  • 48.17 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886107 34
  • 54.53 (n)
hivep3b 35
  • 46 (a)
OneToMany
hivep3a 35
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta shn 36 35
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea sma-9 35
  • 12 (a)
OneToMany
Species where no ortholog for HIVEP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIVEP3 Gene

ENSEMBL:
Gene Tree for HIVEP3 (if available)
TreeFam:
Gene Tree for HIVEP3 (if available)

Paralogs for HIVEP3 Gene

Paralogs for HIVEP3 Gene

(10) SIMAP similar genes for HIVEP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIVEP3: view

Variants for HIVEP3 Gene

Sequence variations from dbSNP and Humsavar for HIVEP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs780211835 A colorectal cancer sample 41,583,348(+) CTTCA(C/T)GCTGT nc-transcript-variant, reference, missense
rs1001925 -- 41,561,890(+) TGTGC(C/T)GTCCA intron-variant
rs1004870 -- 41,905,116(-) AAGCA(A/G)GGCCT intron-variant
rs1007221 -- 41,574,100(-) CAGCA(A/G)TCTGT intron-variant
rs10127462 -- 41,562,834(+) AGcct(C/G)tgcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIVEP3 Gene

Variant ID Type Subtype PubMed ID
dgv156n100 CNV gain 25217958
dgv18e214 CNV loss 21293372
dgv251n54 CNV gain 21841781
esv1535775 CNV deletion 17803354
esv1639858 CNV insertion 17803354
esv21529 CNV gain 19812545
esv2174819 CNV deletion 18987734
esv2229339 CNV deletion 18987734
esv2657722 CNV deletion 23128226
esv2663203 CNV deletion 23128226
esv2669537 CNV deletion 23128226
esv2747463 CNV deletion 23290073
esv2747475 CNV deletion 23290073
esv2747486 CNV deletion 23290073
esv2747497 CNV deletion 23290073
esv2747508 CNV deletion 23290073
esv2747519 CNV deletion 23290073
esv27848 CNV gain 19812545
esv3304449 CNV mobile element insertion 20981092
esv3334333 CNV insertion 20981092
esv3341707 CNV duplication 20981092
esv3360626 CNV insertion 20981092
esv3402472 CNV insertion 20981092
esv3407169 CNV insertion 20981092
esv3577823 CNV loss 25503493
esv3585828 CNV loss 21293372
esv3585829 CNV loss 21293372
esv3585830 CNV loss 21293372
esv3585831 CNV loss 21293372
esv3585833 CNV gain 21293372
esv3585836 CNV loss 21293372
nsv1075475 CNV deletion 25765185
nsv1077794 CNV deletion 25765185
nsv1113108 CNV deletion 24896259
nsv1124231 CNV deletion 24896259
nsv1124566 CNV duplication 24896259
nsv1128603 CNV deletion 24896259
nsv1129460 CNV tandem duplication 24896259
nsv1137752 CNV deletion 24896259
nsv1142057 CNV tandem duplication 24896259
nsv461361 CNV loss 19166990
nsv472825 CNV novel sequence insertion 20440878
nsv474502 CNV novel sequence insertion 20440878
nsv508171 CNV deletion 20534489
nsv517842 CNV loss 19592680
nsv518313 CNV loss 19592680
nsv546108 CNV gain+loss 21841781
nsv546109 CNV loss 21841781
nsv633 CNV deletion 18451855
nsv644 CNV insertion 18451855
nsv655 CNV insertion 18451855
nsv666 CNV deletion 18451855
nsv677 CNV insertion 18451855
nsv829671 CNV loss 17160897
nsv956640 CNV deletion 24416366

Variation tolerance for HIVEP3 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIVEP3 Gene

Human Gene Mutation Database (HGMD)
HIVEP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIVEP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIVEP3 Gene

Disorders for HIVEP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HIVEP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
presbyopia
eye accommodation disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HIVEP3

Genetic Association Database (GAD)
HIVEP3
Human Genome Epidemiology (HuGE) Navigator
HIVEP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIVEP3
genes like me logo Genes that share disorders with HIVEP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIVEP3 Gene

Publications for HIVEP3 Gene

  1. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. (PMID: 11161801) Hicar M.D. … Wu L.-C. (Genomics 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Investigation of the PARK10 gene in Parkinson disease. (PMID: 17388942) Li Y.J. … Vance J.M. (Ann. Hum. Genet. 2007) 3 46 64
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for HIVEP3 Gene

Sources for HIVEP3 Gene

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