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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIVEP3 Gene

protein-coding   GIFtS: 53
GCID: GC01M041974

human immunodeficiency virus type I enhancer binding protein...

(Previous name: human immunodeficiency virus type I enhancer-binding protein...)
 Explore 5 diseases affiliated with
HIVEP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIVEP3    

Aliases
for HIVEP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Human Immunodeficiency Virus Type I Enhancer Binding Protein 31 2     KIAA15551 3
KRC1 2 3 5     Human Immunodeficiency Virus Type I Enhancer-Binding Protein 31 3
KBP-11 2 3     Kappa-B And V(D)J Recombination Signal Sequences-Binding Protein2 3
KBP11 2 3     Kappa-Binding Protein 12 3
ZAS31 2 3     Zinc Finger Protein ZAS32 3
SHN31 2     FLJ167521
Schnurri-31 2     Transcription Factor HIVEP32
ZNF40C1 2     ZAS Family, Member 32

External Ids:    HGNC: 135611   Entrez Gene: 592692   Ensembl: ENSG000001271247   OMIM: 6066495   UniProtKB: Q5T1R43   

Export aliases for HIVEP3 gene to outside databases

Previous GC identifers: GC01M042003 GC01M040979 GC01M041440 GC01M041388 GC01M041644 GC01M041744 GC01M040093


Summaries
for HIVEP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIVEP3:
This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this
protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This
protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding
the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and
J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript
variants. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: ZEP3_HUMAN, Q5T1R4
Function: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic
recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as
S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in
promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens,
mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation
promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits
TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as
transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non
transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in
the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins
inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and
proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of
adult bone formation

Gene Wiki entry for HIVEP3


Genomic Views
for HIVEP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIVEP3 gene promoter:
         Max1   Sox5   AP-1   ATF-2   SREBP-1b   AREB6   Max   c-Jun   Hlf   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIVEP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIVEP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34

HIVEP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIVEP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M041974:  view genomic region     (about GC identifiers)

Start:
 41,972,036 bp from pter      End:
 42,501,596 bp from pter
Size:
 529,561 bases      Orientation:
 minus strand

Proteins
for HIVEP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZEP3_HUMAN, Q5T1R4 (See protein sequence)
Recommended Name: Transcription factor HIVEP3  
Size: 2406 amino acids; 259465 Da
Subunit: Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin
ligase WWP1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=BAB13381.2; Type=Erroneous initiation;
Secondary accessions: A7YY91 Q5T1R5 Q9BZS0 Q9HCL7
Alternative splicing: 2 isoforms:  Q5T1R4-1   Q5T1R4-2   

Explore the universe of human proteins at neXtProt for HIVEP3: NX_Q5T1R4

Post-translational modifications:

  • Phosphorylated on threonine and serine residues (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T1R4

    • HIVEP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121186.1  NP_078779.2  

    ENSEMBL proteins: 
     ENSP00000361665   ENSP00000361664   ENSP00000247584   ENSP00000410828  

    Human Recombinant Protein Products: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for HIVEP3 
    GenScript Custom Purified and Recombinant Proteins Services for HIVEP3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIVEP3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    HIVEP3 for ontologies           About GeneDecksing



    HIVEP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for HIVEP3 
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    Novus Biologicals HIVEP3 Antibody
    Search for Antibodies for HIVEP3 at Abcam  
    Uscn Antibodies for HIVEP3
    Search ThermoFisher Antibodies for HIVEP3

    Assay Products for HIVEP3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIVEP3

    Protein Domains /
    Families
    for HIVEP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIVEP3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5T1R4

    ProtoNet protein and cluster: Q5T1R4

    UniProtKB/Swiss-Prot: ZEP3_HUMAN, Q5T1R4
    Domain: The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred
    DNA-protein structures (By similarity)
    Similarity: Contains 5 C2H2-type zinc fingers


    Function
    for HIVEP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZEP3_HUMAN, Q5T1R4
    Function: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic
    recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as
    S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in
    promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens,
    mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation
    promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits
    TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as
    transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non
    transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in
    the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins
    inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and
    proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of
    adult bone formation
    Induction: By 12-O-tetradecanoylphorbol-13 acetate (TPA)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): HIVEP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP3:
    hsa-miR-217 hsa-miR-27a hsa-miR-513a-5p hsa-miR-3065-5p hsa-miR-124 hsa-miR-506 hsa-miR-3652 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: HIVEP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIVEP3 (see all 7)
    OriGene shRNA RFP: HIVEP3
    OriGene siRNA: HIVEP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIVEP3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP3 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HIVEP3 (NM_024503)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HIVEP3
    Search LifeMap BioReagents cell lines for HIVEP3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    HIVEP3 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for HIVEP3:
     Abundance of large cells with   Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for HIVEP3: Hivep3tm1Glm Hivep3tm1Lcw
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hivep3):
     cellular  hematopoietic system  immune system  limbs/digits/tail  renal/urinary system 
     skeleton  tumorigenesis 

    HIVEP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HIVEP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Notch Signaling Pathway
    		Delta-Notch Signaling Pathway0.27


    1 BioSystems Pathway for HIVEP3 
        Delta-Notch Signaling Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIVEP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for HIVEP3 (Q5T1R43 ENSP000002475844) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHL1Q136423, ENSP000003597244I2D: score=1 STRING: ENSP00000359724
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TNFRSF1BP203333, ENSP000003654354I2D: score=1 STRING: ENSP00000365435
    TRAF1Q130773, ENSP000003629944I2D: score=2 STRING: ENSP00000362994
    TRAF2Q129333, ENSP000002476684I2D: score=2 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IDA15790681


    HIVEP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIVEP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIVEP3
    Search CenterWatch for drugs/clinical trials and news about HIVEP3 / ZEP3 

    Transcripts
    for HIVEP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIVEP3 gene (2 alternative transcripts): 
    NM_001127714.2  NM_024503.4  

    Unigene Clusters for HIVEP3:

    Human immunodeficiency virus type I enhancer binding protein 3
    Hs.403972  [show with all ESTs], Hs.648369  [show with all ESTs]
    Unigene Representative Sequences: NM_024503, AL512747
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372584(uc001cgz.4 uc001cha.4) ENST00000372583(uc001cgy.3)
    ENST00000460604 ENST00000489103(uc001chb.2) ENST00000491442 ENST00000479350
    ENST00000247584 ENST00000429157

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): HIVEP3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP3:
    hsa-miR-217 hsa-miR-27a hsa-miR-513a-5p hsa-miR-3065-5p hsa-miR-124 hsa-miR-506 hsa-miR-3652 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: HIVEP3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIVEP3 (see all 7)
    OriGene shRNA RFP: HIVEP3
    OriGene siRNA: HIVEP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HIVEP3 (NM_024503)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIVEP3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIVEP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIVEP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP3

    Additional cDNA sequence: 

    AL512747.1 BC015242.1 BC040942.1 BC046120.1 BC062792.1 NR_038260.1 NR_038261.1 

    12 DOTS entries:

    DT.412479  DT.100741934  DT.70103182  DT.75158064  DT.310262  DT.100742634  DT.405759  DT.100702381 
    DT.121358412  DT.95164331  DT.97775396  DT.121350840 

    24/66 AceView cDNA sequences (see all 66):

    CD517058 AW502418 BC046120 BC015242 BQ642317 BC040942 AI916992 AL581169 
    BQ061225 CR601823 BQ055216 BQ923173 AB046775 BG421201 N24908 BM874163 
    BP366096 BU955828 AF278765 AW749727 M61743 BG953502 BM819550 AL559577 

    GeneLoc Exon Structure


    Expression
    for HIVEP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIVEP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTGGAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIVEP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIVEP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIVEP3

    SOURCE GeneReport for Unigene clusters: Hs.403972 Hs.648369
        SABiosciences Custom PCR Arrays for HIVEP3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP3

    Orthologs
    for HIVEP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HIVEP3 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HIVEP31 human immunodeficiency virus type I enhancer binding more 68.75(n)
    67.51(a)    		   428208  XM_425767.3  XP_425767.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HIVEP36
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343563.1(223942-225195)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5680371 transcription factor HIVEP2-like 52.15(n)
    48.02(a)    		   568037  XM_691346.4  XP_696438.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta shn3 wing morphogenesis transcription factor 44(a)     --


    ENSEMBL Gene Tree for HIVEP3 (if available)
    TreeFam Gene Tree for HIVEP3 (if available) 

    Paralogs
    for HIVEP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIVEP3 gene
    HIVEP12  ZNF8312  HIVEP22  
    10 SIMAP similar genes for HIVEP3 using alignment to 1 protein entry:     ZEP3_HUMAN:
    KBP-1    ZNF    ZNF844    ZNF78L1    HZF16    DKFZp434J0650
    ZFS-6    ZNF808    DKFZp686N0199    ZNF72

    HIVEP3 for paralogs           About GeneDecksing



    Genomic Variants
    for HIVEP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9087 NCBI SNPs in HIVEP3 are shown (see all 9087)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs775728541,2
    		C,F,--40089970(+) GTGATT/CTGTCA 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs765077551,2
    		F,--40090247(+) ATGCTA/GATTCT 2 -- ut311Minor allele frequency- G:0.02WA 118
    rs771829061,2
    		--40090399(+) CCTTTT/CGTACG 2 -- ut311Minor allele frequency- C:0.01NA 120
    rs740715581,2
    		C,--40091105(+) TGGAAG/ATTGGA 2 -- ut312Minor allele frequency- A:0.07WA 120
    rs764547851,2
    		F,--40091461(+) CTCCTC/TTGCTG 2 -- ut311Minor allele frequency- T:0.03WA 118
    rs716485541,2
    		C,--40091567(+) NNNNCG/ATCTTT 2 -- ut314Minor allele frequency- A:0.11NA WA EA 360
    rs729493691,2
    		C,F,--40091626(+) GGAGCG/AGGACT 2 -- ut313Minor allele frequency- A:0.07WA CSA 122
    rs599440151,2
    		C,--40092183(+) AAAGCC/TCTGGC 2 -- ut312Minor allele frequency- T:0.09CSA WA 120
    rs115869581,2
    		C,F,A,H,--40092331(+) GCTAAC/GCCTGA 2 -- ut318Minor allele frequency- G:0.05NS EA NA 544
    rs285123991,2
    		--40092515(+) AAGAGG/TCAAGT 2 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for HIVEP3 (41972036 - 42222036 bp, first 250kb of HIVEP3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 15 variations for HIVEP3
         9 CNVs: 74459 84194 68462 74456 84193 84191 74458 74457 84192
         6 Indels: 74461 84195 44579 68469 84196 74460

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    Disorders / Diseases
    for HIVEP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIVEP3 for disorders           About GeneDecksing

    OMIM gene information: 606649    OMIM disorders: --

    5 diseases for HIVEP3:    About MalaCards
    immunodeficiency    presbyopia    parkinson's disease    hepatocellular carcinoma
    carcinoma

    1 disease from the University of Copenhagen DISEASES database for HIVEP3:
    Presbyopia
    Human Genome Epidemiology (HuGE) Navigator: HIVEP3 (5 documents)

    Export disorders for HIVEP3 gene to outside databases

    Publications
    for HIVEP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIVEP3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with HIVEP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. (PubMed id 11161801)1, 2, 3 Hicar M.D.... Wu L.-C. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    3. ZAS3 promotes TNFI+-induced apoptosis by blocking NFI^B -activated expression of the anti-apoptotic genes TRAF1 and TRAF2. (PubMed id 21524353)1 Shin D.H....Hong J.W. (2011)
    4. ZAS3 accentuates transforming growth factor I^ signali ng in epithelial cells. (PubMed id 20732416)1 Yakovich A.J....Barnard J.A. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. ZAS3 represses NFI_B-dependent transcription by direct competition for DNA binding. (PubMed id 21189157)1 Hong J.W. and Wu L.C. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. Investigation of the PARK10 gene in Parkinson disease. (PubMed id 17388942)1 Li Y.J....Vance J.M. (2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    External Searches for HIVEP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIVEP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59269 HGNC: 13561 AceView: HIVEP3 Ensembl:ENSG00000127124 euGenes: HUgn59269
    ECgene: HIVEP3 H-InvDB: HIVEP3

    Other Databases showing HIVEP3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1555

    Specialized Databases showing HIVEP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIVEP3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIVEP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIVEP3 gene:
    Search GeneIP for patents involving HIVEP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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