Aliases for HIVEP2 Gene
Aliases for HIVEP2 Gene
External Ids for HIVEP2 Gene
- HGNC: 4921
- Entrez Gene: 3097
- Ensembl: ENSG00000010818
- OMIM: 143054
- UniProtKB: P31629
Previous GeneCards Identifiers for HIVEP2 Gene
- GC06M142919
- GC06M143053
- GC06M143114
- GC06M140638
- GC06M143072
Summaries for HIVEP2 Gene
-
This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]
GeneCards Summary for HIVEP2 Gene
HIVEP2 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 2) is a Protein Coding gene. Diseases associated with HIVEP2 include Hivep2-Related Intellectual Disability. An important paralog of this gene is HIVEP3.
UniProtKB/Swiss-Prot for HIVEP2 Gene
-
This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIVEP2 Gene
Genomics for HIVEP2 Gene
Regulatory Elements for HIVEP2 Gene
Regulatory Element Products
Genomic Location for HIVEP2 Gene
- Chromosome:
- 6
- Start:
- 142,751,467 bp from pter
- End:
- 142,956,698 bp from pter
- Size:
- 205,232 bases
- Orientation:
- Minus strand
Genomic View for HIVEP2 Gene
- Cytogenetic band:
-
- 6q24.2 by Ensembl
- 6q24.2 by Entrez Gene
- 6q24.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIVEP2 Gene
Proteins for HIVEP2 Gene
-
Protein details for HIVEP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31629-ZEP2_HUMAN
- Recommended name:
- Transcription factor HIVEP2
- Protein Accession:
- P31629
- Q02646
- Q5THT5
- Q9NS05
Protein attributes for HIVEP2 Gene
- Size:
- 2446 amino acids
- Molecular mass:
- 269053 Da
- Quaternary structure:
-
- Interacts with TCF4.
- SequenceCaution:
-
- Sequence=AAB88218.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46596.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HIVEP2 Gene
Post-translational modifications for HIVEP2 Gene
Other Protein References for HIVEP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HIVEP2
- Novus Biologicals Antibodies for HIVEP2
- antibodies-online Antibodies for HIVEP2: See all 12
- GeneTex HIVEP2 antibody for HIVEP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HIVEP2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIVEP2
- Origene Custom Protein Services for HIVEP2
- Search GeneTex for Proteins for HIVEP2
Assay Products
- antibodies-online Kits for HIVEP2: See all 3
No data available for DME Specific Peptides for HIVEP2 Gene
Domains & Families for HIVEP2 Gene
Gene Families for HIVEP2 Gene
Protein Domains for HIVEP2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIVEP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HIVEP2 Gene
Function for HIVEP2 Gene
Molecular function for HIVEP2 Gene
- GENATLAS Biochemistry:
- human immunodeficiency virus type 1, enhancer binding protein
- UniProtKB/Swiss-Prot Function:
- This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
- UniProtKB/Swiss-Prot Induction:
- By mitogens and phorbol ester.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | 2022670 |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0043565 | sequence-specific DNA binding | IBA | -- |
| GO:0044212 | transcription regulatory region DNA binding | IBA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for HIVEP2 Gene
- MGI mutant phenotypes for HIVEP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HIVEP2:
Animal Models for HIVEP2 Gene
- MGI Knock Outs for HIVEP2:
-
- Hivep2 tm1Sis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIVEP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIVEP2 gene
- Search ViGene Biosciences for HIVEP2
CRISPR Products
-
OriGene CRISPR knockouts for HIVEP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIVEP2
- GenScript: Design CRISPR guide RNA sequences for HIVEP2
miRNA for HIVEP2 Gene
- miRTarBase miRNAs that target HIVEP2
-
- hsa-mir-155-5p (MIRT000974)
- hsa-mir-130b-3p (MIRT020335)
- hsa-mir-598-3p (MIRT040488)
- hsa-mir-484 (MIRT041806)
- hsa-mir-10b-5p (MIRT439126)
- hsa-mir-136-5p (MIRT440502)
- hsa-mir-298 (MIRT536857)
- hsa-mir-5684 (MIRT536858)
- hsa-mir-5700 (MIRT536859)
- hsa-mir-519c-3p (MIRT536860)
- hsa-mir-519b-3p (MIRT536861)
- hsa-mir-519a-3p (MIRT536862)
- hsa-mir-4662a-3p (MIRT536863)
- hsa-mir-520c-3p (MIRT536864)
- hsa-mir-520d-3p (MIRT536865)
- hsa-mir-302c-3p (MIRT536866)
- hsa-mir-372-3p (MIRT536867)
- hsa-mir-520e (MIRT536868)
- hsa-mir-520b (MIRT536869)
- hsa-mir-373-3p (MIRT536870)
- hsa-mir-520a-3p (MIRT536871)
- hsa-mir-302e (MIRT536872)
- hsa-mir-302d-3p (MIRT536873)
- hsa-mir-302b-3p (MIRT536874)
- hsa-mir-302a-3p (MIRT536875)
miRNA Products
- Search ViGene Biosciences for HIVEP2
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for HIVEP2
- Browse OriGene Inhibitory RNA Products For HIVEP2
-
ViGene Biosciences ready-to-package AAV shRNAs for HIVEP2 gene
Cell Line Products
-
Horizon Cell Lines for HIVEP2
-
ViGene Biosciences adenoviral particle packaged cDNA for HIVEP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIVEP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIVEP2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIVEP2 Gene
Localization for HIVEP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIVEP2 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IBA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for HIVEP2 Gene
Interacting Proteins for HIVEP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IBA,IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IBA | -- |
| GO:0007165 | signal transduction | IBA | -- |
| GO:0007275 | multicellular organism development | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HIVEP2 Gene
Transcripts for HIVEP2 Gene
mRNA/cDNA for HIVEP2 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (131) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIVEP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIVEP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIVEP2
- GenScript: Design CRISPR guide RNA sequences for HIVEP2
miRNA Products
- Search ViGene Biosciences for HIVEP2
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for HIVEP2
- Browse OriGene Inhibitory RNA Products For HIVEP2
-
ViGene Biosciences ready-to-package AAV shRNAs for HIVEP2 gene
Flow Cytometry Products
Expression for HIVEP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Visceral White Preadipocytes Visceral White Adipose
- Subcutaneous White Preadipocytes Body Subcutaneous White Adipose
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Brain (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIVEP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HIVEP2 Gene:
HIVEP2SOURCE GeneReport for Unigene cluster for HIVEP2 Gene:
Hs.510172mRNA Expression by UniProt/SwissProt for HIVEP2 Gene:
P31629-ZEP2_HUMANEvidence on tissue expression from TISSUES for HIVEP2 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs for HIVEP2
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIVEP2 Gene
Orthologs for HIVEP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIVEP2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HIVEP2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HIVEP2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hivep2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hivep2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HIVEP2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIVEP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HIVEP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hivep2 34 |
|
||
| Str.13398 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | hivep2a 34 35 |
|
||
| HIVEP2 (1 of 2) 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | shn 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sma-9 35 |
|
OneToMany |
- Species where no ortholog for HIVEP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIVEP2 Gene
Variants for HIVEP2 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs761993070 | Pathogenic | 142,759,813(+) | CTGTC(A/C/G/T)CATGG | reference, missense | |
| rs869312841 | Pathogenic | 142,771,912(-) | GTCTG(C/T)GACTT | reference, stop-gained | |
| rs869312842 | Pathogenic | 142,771,834(-) | CCAGC(C/T)AAGAA | reference, stop-gained | |
| rs869312843 | Pathogenic | 142,771,882(-) | CAGGG(G/T)AGTCC | reference, stop-gained | |
| rs869312844 | Pathogenic | 142,761,469(-) | TGAGG(-/G)AAGCA | reference, frameshift-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1021e201 | CNV | deletion | 23290073 |
| dgv1158e199 | CNV | deletion | 23128226 |
| dgv1227e214 | CNV | gain | 21293372 |
| dgv3407n106 | CNV | deletion | 24896259 |
| esv2130804 | CNV | deletion | 18987734 |
| esv2732809 | CNV | deletion | 23290073 |
| esv2732810 | CNV | deletion | 23290073 |
| esv2732811 | CNV | deletion | 23290073 |
| esv2732812 | CNV | deletion | 23290073 |
| esv2732814 | CNV | deletion | 23290073 |
| esv2732816 | CNV | deletion | 23290073 |
| esv3402921 | CNV | duplication | 20981092 |
| esv3540579 | CNV | deletion | 23714750 |
| esv3611084 | CNV | loss | 21293372 |
| esv3611085 | CNV | loss | 21293372 |
| esv5938 | CNV | gain | 19470904 |
| esv6993 | CNV | gain | 19470904 |
| nsv1019558 | CNV | loss | 25217958 |
| nsv1073592 | CNV | deletion | 25765185 |
| nsv1153921 | CNV | deletion | 26484159 |
| nsv520992 | CNV | loss | 19592680 |
| nsv819036 | CNV | loss | 19587683 |
| nsv830828 | CNV | gain | 17160897 |
| nsv830829 | CNV | loss | 17160897 |
| nsv949861 | CNV | duplication | 24416366 |
| nsv950515 | CNV | duplication | 24416366 |
| nsv958349 | CNV | deletion | 24416366 |
Relevant External Links for HIVEP2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIVEP2 Gene
Disorders for HIVEP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hivep2-related intellectual disability |
|
|
UniProtKB/Swiss-Prot
ZEP2_HUMAN- Mental retardation, autosomal dominant 43 (MRD43) [MIM:616977]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD43 patients manifest developmental delay, intellectual disability, hypotonia, and dysmorphic features. {ECO:0000269 PubMed:23020937, ECO:0000269 PubMed:26153216}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HIVEP2
No data available for Genatlas for HIVEP2 Gene
Publications for HIVEP2 Gene
- HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1. (PMID: 2022670) Nomura N. … Ishii S. (J. Biol. Chem. 1991) 2 3 4 22 64
- Loss-of-function variants in HIVEP2 are a cause of intellectual disability. (PMID: 26153216) Srivastava S. … Naidu S. (Eur. J. Hum. Genet. 2016) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
- Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. (PMID: 10207097) Doerflinger U. … Buettner R. (Mol. Cell. Biol. 1999) 3 4 64
- Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24. (PMID: 1733857) Sudo T. … Ishii S. (Genomics 1992) 2 3 64
Products for HIVEP2 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for HIVEP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIVEP2
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- GenScript: Design CRISPR guide RNA sequences for HIVEP2
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- antibodies-online Antibodies for HIVEP2: See all 12
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- Search antibodies-online for proteins
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- ViGene Biosciences adenoviral particle packaged cDNA for HIVEP2 gene
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- Search ViGene Biosciences for HIVEP2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIVEP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
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- (88) miRTarBase
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- (90) Invitrogen
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- (92) Vector BioLabs
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- (95) BioSystems
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- (98) BioGPS
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- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (141) ENCODE
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- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




