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Aliases for HIVEP2 Gene

Aliases for HIVEP2 Gene

  • Human Immunodeficiency Virus Type I Enhancer Binding Protein 2 2 3
  • Human Immunodeficiency Virus Type I Enhancer-Binding Protein 2 2 3 4
  • C-Myc Intron Binding Protein 1 2 3
  • MHC-Binding Protein 2 3 4
  • HIV-EP2 3 4
  • MBP-2 3 4
  • Transcription Factor HIVEP2 3
  • MHC Binding Protein-2 3
  • Schnurri-2 3
  • ZNF40B 3
  • MIBP1 3
  • SHN2 3
  • ZAS2 3

External Ids for HIVEP2 Gene

Previous GeneCards Identifiers for HIVEP2 Gene

  • GC06M142919
  • GC06M143053
  • GC06M143114
  • GC06M140638
  • GC06M143072

Summaries for HIVEP2 Gene

Entrez Gene Summary for HIVEP2 Gene

  • This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]

GeneCards Summary for HIVEP2 Gene

HIVEP2 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 2) is a Protein Coding gene. An important paralog of this gene is HIVEP1.

UniProtKB/Swiss-Prot for HIVEP2 Gene

  • This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation

Gene Wiki entry for HIVEP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIVEP2 Gene

Genomics for HIVEP2 Gene

Regulatory Elements for HIVEP2 Gene

Genomic Location for HIVEP2 Gene

Start:
142,751,467 bp from pter
End:
142,946,358 bp from pter
Size:
194,892 bases
Orientation:
Minus strand

Genomic View for HIVEP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIVEP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIVEP2 Gene

Proteins for HIVEP2 Gene

  • Protein details for HIVEP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31629-ZEP2_HUMAN
    Recommended name:
    Transcription factor HIVEP2
    Protein Accession:
    P31629
    Secondary Accessions:
    • Q02646
    • Q5THT5
    • Q9NS05

    Protein attributes for HIVEP2 Gene

    Size:
    2446 amino acids
    Molecular mass:
    269053 Da
    Quaternary structure:
    • Interacts with TCF4.
    SequenceCaution:
    • Sequence=AAB88218.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46596.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HIVEP2 Gene

Proteomics data for HIVEP2 Gene at MOPED

Post-translational modifications for HIVEP2 Gene

  • Ubiquitination at Lys2092
  • Modification sites at PhosphoSitePlus

Other Protein References for HIVEP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIVEP2 Gene

Domains for HIVEP2 Gene

Gene Families for HIVEP2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for HIVEP2 Gene

Suggested Antigen Peptide Sequences for HIVEP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31629

UniProtKB/Swiss-Prot:

ZEP2_HUMAN :
  • P31629
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HIVEP2: view

Function for HIVEP2 Gene

Molecular function for HIVEP2 Gene

GENATLAS Biochemistry:
human immunodeficiency virus type 1, enhancer binding protein
UniProtKB/Swiss-Prot Function:
This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation
UniProtKB/Swiss-Prot Induction:
By mitogens and phorbol ester

Gene Ontology (GO) - Molecular Function for HIVEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 2022670
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HIVEP2: view

Phenotypes for HIVEP2 Gene

genes like me logo Genes that share phenotypes with HIVEP2: view

Animal Models for HIVEP2 Gene

MGI Knock Outs for HIVEP2:

Animal Model Products

CRISPR Products

miRNA for HIVEP2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIVEP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HIVEP2 Gene

Localization for HIVEP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIVEP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIVEP2 Gene COMPARTMENTS Subcellular localization image for HIVEP2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIVEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HIVEP2: view

Pathways for HIVEP2 Gene

SuperPathways for HIVEP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIVEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HIVEP2: view

No data available for Pathways by source for HIVEP2 Gene

Transcripts for HIVEP2 Gene

mRNA/cDNA for HIVEP2 Gene

Unigene Clusters for HIVEP2 Gene

Human immunodeficiency virus type I enhancer binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIVEP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIVEP2 Gene

No ASD Table

Relevant External Links for HIVEP2 Gene

GeneLoc Exon Structure for
HIVEP2
ECgene alternative splicing isoforms for
HIVEP2

Expression for HIVEP2 Gene

mRNA expression in normal human tissues for HIVEP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HIVEP2 Gene

This gene is overexpressed in Nasal epithelium (62.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HIVEP2 Gene

SOURCE GeneReport for Unigene cluster for HIVEP2 Gene Hs.510172

mRNA Expression by UniProt/SwissProt for HIVEP2 Gene

P31629-ZEP2_HUMAN
Tissue specificity: Expressed in brain and skeletal muscle.
genes like me logo Genes that share expressions with HIVEP2: view

Expression partners for HIVEP2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HIVEP2 Gene

Orthologs for HIVEP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIVEP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIVEP2 35
  • 87.9 (n)
  • 90.23 (a)
HIVEP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIVEP2 35
  • 90.75 (n)
  • 92.55 (a)
HIVEP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hivep2 35
  • 85.37 (n)
  • 87.93 (a)
Hivep2 16
Hivep2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIVEP2 35
  • 99.63 (n)
  • 99.63 (a)
HIVEP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hivep2 35
  • 85.32 (n)
  • 88 (a)
oppossum
(Monodelphis domestica)
Mammalia HIVEP2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIVEP2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves HIVEP2 35
  • 74.45 (n)
  • 74.22 (a)
HIVEP2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hivep2 35
  • 65.82 (n)
  • 62.45 (a)
Str.13398 35
zebrafish
(Danio rerio)
Actinopterygii hivep2a 35
  • 56.73 (n)
  • 52.07 (a)
HIVEP2 (1 of 2) 36
  • 41 (a)
OneToMany
hivep2a 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta shn 37
  • 41 (a)
shn 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-9 36
  • 12 (a)
OneToMany
Species with no ortholog for HIVEP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIVEP2 Gene

ENSEMBL:
Gene Tree for HIVEP2 (if available)
TreeFam:
Gene Tree for HIVEP2 (if available)

Paralogs for HIVEP2 Gene

Paralogs for HIVEP2 Gene

Selected SIMAP similar genes for HIVEP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIVEP2: view

Variants for HIVEP2 Gene

Sequence variations from dbSNP and Humsavar for HIVEP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3383 -- 142,751,904(+) CCATC(C/T)CCTTT utr-variant-3-prime
rs84578 -- 142,780,425(-) TCAAA(C/T)ATGTT intron-variant
rs107118 -- 142,866,789(-) ATTAG(A/G)GTAAA intron-variant
rs107119 -- 142,866,720(-) AAAGC(C/G)CTTTC intron-variant
rs109301 -- 142,868,080(+) GCAAG(A/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIVEP2 Gene

Variant ID Type Subtype PubMed ID
nsv830828 CNV Gain 17160897
nsv830829 CNV Loss 17160897
nsv520992 CNV Loss 19592680
esv2732809 CNV Deletion 23290073
esv2732810 CNV Deletion 23290073
esv2732811 CNV Deletion 23290073
esv2130804 CNV Deletion 18987734
esv2732812 CNV Deletion 23290073
dgv1068e201 CNV Deletion 23290073
esv2732814 CNV Deletion 23290073
esv2732816 CNV Deletion 23290073
esv6993 CNV Gain 19470904
esv5938 CNV Gain 19470904
nsv819036 CNV Loss 19587683
dgv1158e199 CNV Deletion 23128226

Relevant External Links for HIVEP2 Gene

HapMap Linkage Disequilibrium report
HIVEP2
Human Gene Mutation Database (HGMD)
HIVEP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIVEP2 Gene

Disorders for HIVEP2 Gene

(2) Novoseek inferred disease relationships for HIVEP2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
cancer 0 1

Relevant External Links for HIVEP2

Genetic Association Database (GAD)
HIVEP2
genes like me logo Genes that share disorders with HIVEP2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HIVEP2 Gene

Publications for HIVEP2 Gene

  1. HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1. (PMID: 2022670) Nomura N. … Ishii S. (J. Biol. Chem. 1991) 2 3 4 23
  2. Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes. (PMID: 1409593) Van't Veer L.J. … Bernards R. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4
  3. Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24. (PMID: 1733857) Sudo T. … Ishii S. (Genomics 1992) 2 3
  4. Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties. (PMID: 2247438) Rustgi A.K. … Bernards R. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4
  5. Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. (PMID: 10207097) Doerflinger U. … Buettner R. (Mol. Cell. Biol. 1999) 3 4

Products for HIVEP2 Gene

Sources for HIVEP2 Gene

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