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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIVEP2 Gene

protein-coding   GIFtS: 53
GCID: GC06M143114

human immunodeficiency virus type I enhancer binding protein...

(Previous name: human immunodeficiency virus type I enhancer-binding protein...)
 Explore 7 diseases affiliated with
HIVEP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIVEP2    

Aliases
for HIVEP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Human Immunodeficiency Virus Type I Enhancer Binding Protein 21 2     ZNF40B1 2
Human Immunodeficiency Virus Type I Enhancer-Binding Protein 21 2 3     MHC-Binding Protein 22 3
HIV-EP21 2 3     SHN22
MBP-21 2 3     C-Myc Intron Binding Protein 12
MIBP11 2     MHC Binding Protein-22
Schnurri-21 2     Transcription Factor HIVEP22
ZAS21 2     

External Ids:    HGNC: 49211   Entrez Gene: 30972   Ensembl: ENSG000000108187   OMIM: 1430545   UniProtKB: P316293   

Export aliases for HIVEP2 gene to outside databases

Previous GC identifers: GC06M142695 GC06M142919 GC06M143053 GC06M140638


Summaries
for HIVEP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIVEP2:
This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The
encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that
maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely
separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence.
(provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements
of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the
enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor,
somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation

Gene Wiki entry for HIVEP2


Genomic Views
for HIVEP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIVEP2 gene promoter:
         USF1   GATA-3   CUTL1   IRF-1   Ik-3   S8   E2F-1   USF-1   Zic3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIVEP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIVEP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIVEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q24.2   HGNC cytogenetic band: 6q23-q24

HIVEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIVEP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M143114:  view genomic region     (about GC identifiers)

Start:
 143,072,604 bp from pter      End:
 143,266,338 bp from pter
Size:
 193,735 bases      Orientation:
 minus strand

Proteins
for HIVEP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629 (See protein sequence)
Recommended Name: Transcription factor HIVEP2  
Size: 2446 amino acids; 269053 Da
Subunit: Interacts with TCF4 (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=AAB88218.1; Type=Erroneous initiation; Sequence=CAA46596.1; Type=Erroneous initiation;
Secondary accessions: Q02646 Q5THT5 Q9NS05

Explore the universe of human proteins at neXtProt for HIVEP2: NX_P31629

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31629

    • HIVEP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006725.3  
    ENSEMBL proteins: 
     ENSP00000356576   ENSP00000012134   ENSP00000356575  

    Human Recombinant Protein Products: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for HIVEP2 
    GenScript Custom Purified and Recombinant Proteins Services for HIVEP2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIVEP2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    HIVEP2 for ontologies           About GeneDecksing



    HIVEP2 Antibody Products: 
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    Novus Biologicals HIVEP2 Antibody
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    Uscn Antibodies for HIVEP2
    Search ThermoFisher Antibodies for HIVEP2

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    GenScript Custom Assay Services for HIVEP2
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    Uscn ELISAs and CLIAs for HIVEP2

    Protein Domains /
    Families
    for HIVEP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIVEP2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P31629

    ProtoNet protein and cluster: P31629

    UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
    Similarity: Contains 4 C2H2-type zinc fingers


    Function
    for HIVEP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
    Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements
    of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the
    enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor,
    somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation
    Induction: By mitogens and phorbol ester

         Genatlas biochemistry entry for HIVEP2:
    human immunodeficiency virus type 1, enhancer binding protein

    miRNA
    Products:            		miRTarBase miRNAs that target HIVEP2:
    hsa-mir-155 (MIRT000974)

    OriGene 3'-UTR Clone: HIVEP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP2
    8/111 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP2 (see all 111):
    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: HIVEP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIVEP2 (see all 7)
    OriGene shRNA RFP: HIVEP2
    OriGene siRNA: HIVEP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIVEP2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIVEP2 (NM_006734)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HIVEP2
    Search LifeMap BioReagents cell lines for HIVEP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS2247438
    GO:0008270zinc ion binding IEA--


    HIVEP2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for HIVEP2:
     Increased S DNA content  Increased cell size  S arrest 

    Animal Models:
         Mouse knock-out Hivep2tm1Sis for HIVEP2
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hivep2):
     cellular  hematopoietic system  immune system 

    HIVEP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HIVEP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIVEP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/14 Interacting proteins for HIVEP2 (P316292, 3 ENSP000000121344) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    FBXW11Q9UKB13, ENSP000002650944I2D: score=2 STRING: ENSP00000265094
    RFX1P226703, ENSP000002543254I2D: score=1 STRING: ENSP00000254325
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--


    HIVEP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIVEP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIVEP2
    Search CenterWatch for drugs/clinical trials and news about HIVEP2 / ZEP2 

    Transcripts
    for HIVEP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIVEP2 gene: 
    NM_006734.3  

    Unigene Cluster for HIVEP2:

    Human immunodeficiency virus type I enhancer binding protein 2
    Hs.510172  [show with all ESTs]
    Unigene Representative Sequence: NM_006734
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367604 ENST00000012134 ENST00000474532 ENST00000367603(uc003qjd.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: HIVEP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP2
    8/111 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP2 (see all 111):
    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: HIVEP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIVEP2 (see all 7)
    OriGene shRNA RFP: HIVEP2
    OriGene siRNA: HIVEP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIVEP2 (NM_006734)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIVEP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIVEP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIVEP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP2

    Additional cDNA sequence: 

    AK226163.1 AK296531.1 BC032679.1 CR936782.1 DQ231041.1 M61744.1 X65644.1 

    5 DOTS entries:

    DT.99939994  DT.317616  DT.95168479  DT.204400  DT.92333502 

    24/131 AceView cDNA sequences (see all 131):

    F02143 BM975390 N45264 BP361240 M61744 X65644 BQ187480 BM468942 
    AA244493 AA033892 F13205 AW628113 AA557381 BP335214 AL698286 NM_006734 
    AW439617 BQ018752 AW779787 BQ717297 CA503382 BU428863 F07489 AI684058 

    GeneLoc Exon Structure


    Expression
    for HIVEP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIVEP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIVEP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
    AdiposeVisceral White AdiposeVisceral White PreadipocytesAdipose
    AdiposeCranial Subcutaneous White AdiposePreadipocytesAdipose
    AdiposeCranial Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
    AdiposeFacial Subcutaneous White AdiposePreadipocytesAdipose
    AdiposeFacial Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
    AdiposeSubcutaneous White AdiposePreadipocytesAdipose
    AdiposeSubcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
    Lateral Plate MesodermLateral Plate MesodermCommon PreadipocyteAdipose
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIVEP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIVEP2

    SOURCE GeneReport for Unigene cluster: Hs.510172

    UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
    Tissue specificity: Expressed in brain and skeletal muscle

        SABiosciences Custom PCR Arrays for HIVEP2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP2

    Orthologs
    for HIVEP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HIVEP2 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HIVEP21 human immunodeficiency virus type I enhancer binding more 74.79(n)
    74.98(a)    		   421672  XM_419711.3  XP_419711.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 69(a)
    67(a)
    		 1 ↔ many
    1 ↔ many
    		 1(203410572-203423204)
    1(203441314-203448161)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AW158907.12   -- 80.19(n)    AW158907.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hivep21 human immunodeficiency virus type I enhancer binding more 56.18(n)
    50.8(a)    		   562048  NM_001030164.1  NP_001025335.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta shn3 wing morphogenesis transcription factor 41(a)     --


    ENSEMBL Gene Tree for HIVEP2 (if available)
    TreeFam Gene Tree for HIVEP2 (if available) 

    Paralogs
    for HIVEP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIVEP2 gene
    HIVEP12  ZNF8312  HIVEP32  
    10 SIMAP similar genes for HIVEP2 using alignment to 1 protein entry:     ZEP2_HUMAN:
    MIBP1    KBP-1    DKFZp434J0650    ZNF844    ZNF    HZF16
    ZNF78L1    A-328A3.4    kr-znf3    ZFS-3

    HIVEP2 for paralogs           About GeneDecksing



    Genomic Variants
    for HIVEP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3087 NCBI SNPs in HIVEP2 are shown (see all 3087)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452324071,2
    		--143072187(+) GATTTA/GTGGGT 1 -- int10--------
    rs1929950121,2
    		--143072223(+) CTTAGC/TTTCAG 1 -- int10--------
    rs780599591,2
    		F,--143072266(+) CAGTGG/AAATTT 1 -- int11Minor allele frequency- A:0.03EA 120
    rs5764201,2
    		C,F,O,H,--143072350(+) GCAACG/ATATGC 1 -- int131Minor allele frequency- A:0.09NA NS EA WA CSA 3328
    rs1398051411,2
    		C,--143072417(+) GACCA-/CTAT  
                CTGTT     		1 -- int10--------
    rs1848487941,2
    		--143072588(+) AACACA/TTAAGA 1 -- int10--------
    rs735824681,2
    		C,--143072771(+) CTGCAC/TCCCTC 1 -- ut312Minor allele frequency- T:0.03WA 120
    rs767348241,2
    		F,--143072873(+) TCCCAC/GGAGTT 1 -- ut311Minor allele frequency- G:0.19WA 118
    rs1136525811,2
    		C,F,--143072909(+) CCATTC/TCCCCT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs1435303871,2
    		C,--143072949(+) CTATG-/AAAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HIVEP2 (143072604 - 143266338 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for HIVEP2
         3 CNVs: 51813 59302 4509
         2 Indels: 60628 60627
    Human Gene Mutation Database (HGMD): HIVEP2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIVEP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HIVEP2

    Disorders / Diseases
    for HIVEP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIVEP2 for disorders           About GeneDecksing

    OMIM gene information: 143054    OMIM disorders: --

    7 diseases for HIVEP2:    About MalaCards
    immunodeficiency    chronic myeloid leukemia    myeloid leukemia    leukemia
    prostate cancer    breast cancer    prostatitis

    2 Novoseek disease relationships for HIVEP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 2022670 (1)
    cancer 0 1 15805119 (1)


    Export disorders for HIVEP2 gene to outside databases

    Publications
    for HIVEP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIVEP2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with HIVEP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1. (PubMed id 2022670)1, 2, 3, 9 Nomura N....Ishii S. (1991)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. Specific activation of SSTR-2 promoter by SEF-2 and MIBP-1. (PubMed id 10207097)1, 2 Doerflinger U....Buettner R. (1999)
    4. Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24. (PubMed id 1733857)1, 3 Sudo T....Ishii S. (1992)
    5. Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes. (PubMed id 1409593)1, 2 Van't Veer L.J.... Bernards R. (1992)
    6. Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties. (PubMed id 2247438)1, 2 Rustgi A.K.... Bernards R. (1990)
    7. Genome-wide repression of NF-kB target genes by transc ription factor MIBP1 and its modulation by O-linked b-N-acetylglucosamine (O-Glc NAc) transferase. (PubMed id 22294689)1 Iwashita Y....Tahira T. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)

    External Searches for HIVEP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing HIVEP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3097 HGNC: 4921 AceView: HIVEP2 Ensembl:ENSG00000010818 euGenes: HUgn3097
    ECgene: HIVEP2 H-InvDB: HIVEP2

    Other Databases showing HIVEP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIVEP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIVEP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIVEP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIVEP2 gene:
    Search GeneIP for patents involving HIVEP2

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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