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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIVEP2 Gene

protein-coding   GIFtS: 55
GCID: GC06M143114

Human Immunodeficiency Virus Type I Enhancer Binding Protein...

(Previous name: human immunodeficiency virus type I enhancer-binding protein...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Human Immunodeficiency Virus Type I Enhancer Binding Protein 21 2     SHN22
Human Immunodeficiency Virus Type I Enhancer-Binding Protein 21 2 3     Schnurri-22
C-Myc Intron Binding Protein 11 2     ZAS22
HIV-EP22 3     ZNF40B2
MBP-22 3     MHC Binding Protein-22
MHC-Binding Protein 22 3     Transcription Factor HIVEP22
MIBP12     

External Ids:    HGNC: 49211   Entrez Gene: 30972   Ensembl: ENSG000000108187   OMIM: 1430545   UniProtKB: P316293   

Export aliases for HIVEP2 gene to outside databases

Previous GC identifers: GC06M142695 GC06M142919 GC06M143053 GC06M140638


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIVEP2 Gene:
This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors.
The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes
that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two
widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a
serine/threonine-rich sequence. (provided by RefSeq, Nov 2012)

GeneCards Summary for HIVEP2 Gene: 
HIVEP2 (human immunodeficiency virus type I enhancer binding protein 2) is a protein-coding gene. Diseases associated with HIVEP2 include chronic myeloid leukemia, and myeloid leukemia. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is HIVEP1.

UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer
elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are
found in the enhancer elements of a number of cellular promoters, including those of the class I MHC,
interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation

Gene Wiki entry for HIVEP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIVEP2 gene promoter:
         USF1   GATA-3   CUTL1   IRF-1   Ik-3   S8   E2F-1   USF-1   Zic3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIVEP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIVEP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIVEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q24.2   HGNC cytogenetic band: 6q23-q24

HIVEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIVEP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M143114:  view genomic region     (about GC identifiers)

Start:
143,072,604 bp from pter      End:
143,266,338 bp from pter
Size:
193,735 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629 (See protein sequence)
Recommended Name: Transcription factor HIVEP2  
Size: 2446 amino acids; 269053 Da
Subunit: Interacts with TCF4 (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=AAB88218.1; Type=Erroneous initiation; Sequence=CAA46596.1; Type=Erroneous initiation;
Secondary accessions: Q02646 Q5THT5 Q9NS05

Explore the universe of human proteins at neXtProt for HIVEP2: NX_P31629

Explore proteomics data for HIVEP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31629

  • HIVEP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIVEP2 Protein Expression
    REFSEQ proteins: NP_006725.3  
    ENSEMBL proteins: 
     ENSP00000356576   ENSP00000012134   ENSP00000356575  

    Human Recombinant Protein Products for HIVEP2: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HIVEP2
    GenScript Custom Purified and Recombinant Proteins Services for HIVEP2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIVEP2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    HIVEP2 for ontologies           About GeneDecksing



    HIVEP2 Antibody Products: 
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    Novus Biologicals HIVEP2 Antibody
    Abcam antibodies for HIVEP2
    Cloud-Clone Corp. Antibodies for HIVEP2 
    Search ThermoFisher Antibodies for HIVEP2
    LSBio Antibodies in human, mouse, rat for HIVEP2 

    Assay Products for HIVEP2: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HIVEP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIVEP2 
    Cloud-Clone Corp. CLIAs for HIVEP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P31629

    ProtoNet protein and cluster: P31629

    UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
    Similarity: Contains 4 C2H2-type zinc fingers


    HIVEP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZEP2_HUMAN, P31629
    Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer
    elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are
    found in the enhancer elements of a number of cellular promoters, including those of the class I MHC,
    interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation
    Induction: By mitogens and phorbol ester

         Genatlas biochemistry entry for HIVEP2:
    human immunodeficiency virus type 1, enhancer binding protein

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS2022670
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    HIVEP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HIVEP2:
     Increased S DNA content  Increased cell size  S arrest 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hivep2):
     cellular  hematopoietic system  immune system 

    HIVEP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hivep2tm1Sis for HIVEP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIVEP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIVEP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIVEP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIVEP2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIVEP2:
    hsa-mir-155 (MIRT000974)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP2
    8/111 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP2 (see all 111):
    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidHIVEP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIVEP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIVEP2


    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HIVEP2 (see all 5)
    OriGene ORF clones in mouse, rat for HIVEP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIVEP2 (NM_006734)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HIVEP2
    Search LifeMap BioReagents cell lines for HIVEP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIVEP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/20 Interacting proteins for HIVEP2 (P316292, 3 ENSP000000121344) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--

    HIVEP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIVEP2 (ZEP2)

    Search CenterWatch for drugs/clinical trials and news about HIVEP2 / ZEP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIVEP2 gene: 
    NM_006734.3  

    Unigene Cluster for HIVEP2:

    Human immunodeficiency virus type I enhancer binding protein 2
    Hs.510172  [show with all ESTs]
    Unigene Representative Sequence: NM_006734
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367604 ENST00000012134 ENST00000474532 ENST00000367603(uc003qjd.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP2
    8/111 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP2 (see all 111):
    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidHIVEP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIVEP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP2
    Clone
    Products:
         
    OriGene clones in human, mouse for HIVEP2 (see all 5)
    OriGene ORF clones in mouse, rat for HIVEP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIVEP2 (NM_006734)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HIVEP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIVEP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIVEP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP2

    Additional mRNA sequence: 

    AK226163.1 AK296531.1 BC032679.1 CR936782.1 DQ231041.1 M61744.1 X65644.1 

    5 DOTS entries:

    DT.99939994  DT.317616  DT.95168479  DT.204400  DT.92333502 

    24/131 AceView cDNA sequences (see all 131):

    F02143 N45264 BM975390 X65644 BQ187480 AL597327 F13205 M61744 
    NM_006734 AL698286 BP335214 BP361240 AI684058 F07489 CA503382 BQ018752 
    AA033892 AA244493 T29332 BU428863 AW628113 AW439617 AA557381 BQ717297 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIVEP2 expression in normal human tissues (normalized intensities)      HIVEP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIVEP2 Expression
    About this image


    HIVEP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 9 entries
             Subcutaneous White Preadipocytes Body Subcutaneous White Adipose
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Common Preadipocyte Lateral Plate Mesoderm
     
     Brain (Nervous System)
             Cerebral Cortex

    See HIVEP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIVEP2

    SOURCE GeneReport for Unigene cluster: Hs.510172

    UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
    Tissue specificity: Expressed in brain and skeletal muscle

        SABiosciences Custom PCR Arrays for HIVEP2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HIVEP2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hivep21 , 5 human immunodeficiency virus type I enhancer binding more1, 5 85.35(n)1
    87.93(a)1
      10 (5.14 cM)5
    152731  NM_010437.21  NP_034567.21 
     139663795 
    chicken
    (Gallus gallus)
    Aves HIVEP21 human immunodeficiency virus type I enhancer binding more 74.79(n)
    74.98(a)
      421672  XM_419711.3  XP_419711.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    HIVEP26
    Uncharacterized protein
    69(a)
    68(a)
    1 ↔ many
    1 ↔ many
    1(203410572-203423204)
    1(203441314-203448161)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW158907.12   -- 80.19(n)    AW158907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hivep21 human immunodeficiency virus type I enhancer binding more 56.18(n)
    50.8(a)
      562048  NM_001030164.1  NP_001025335.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shn3 wing morphogenesis transcription factor 41(a)     --


    ENSEMBL Gene Tree for HIVEP2 (if available)
    TreeFam Gene Tree for HIVEP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIVEP2 gene
    HIVEP12  ZNF8312  HIVEP32  
    9 SIMAP similar genes for HIVEP2 using alignment to 1 protein entry:     ZEP2_HUMAN:
    MIBP1    KBP-1    DKFZp434J0650    ZNF844    ZNF    HZF16
    ZNF78L1    A-328A3.4    kr-znf3

    HIVEP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3706 SNPs in HIVEP2 are shown (see all 3706)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452324071,2
    C--143072187(+) GATTTA/GTGGGT 1 -- ds50010--------
    rs1929950121,2
    --143072223(+) CTTAGC/TTTCAG 1 -- ds50010--------
    rs780599591,2
    C,F--143072266(+) CAGTGG/AAATTT 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs5764201,2
    C,F,O,H--143072350(+) GCAACG/ATATGC 1 -- ds500131Minor allele frequency- A:0.09NA NS EA WA CSA 3328
    rs1398051411,2
    C--143072417(+) GACCA-/CTAT  
            
    CTGTT
    1 -- ds50010--------
    rs1848487941,2
    --143072588(+) AACACA/TTAAGA 1 -- ds50010--------
    rs735824681,2
    C,F--143072771(+) CTGCAC/TCCCTC 1 -- ut312Minor allele frequency- T:0.03WA 120
    rs767348241,2
    C,F--143072873(+) TCCCAC/GGAGTT 1 -- ut311Minor allele frequency- G:0.19WA 118
    rs1136525811,2
    C,F--143072909(+) CCATTC/TCCCCT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs1435303871,2
    C--143072949(+) CTATG-/AAAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HIVEP2 (143072604 - 143266338 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for HIVEP2 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732816CNV Deletion23290073
    esv2732812CNV Deletion23290073
    esv2732811CNV Deletion23290073
    esv2732809CNV Deletion23290073
    dgv1158e199CNV Deletion23128226
    esv2732810CNV Deletion23290073
    esv2130804CNV Deletion18987734
    dgv1068e201CNV Deletion23290073
    esv2732814CNV Deletion23290073
    nsv830829CNV Loss17160897


    Human Gene Mutation Database (HGMD): HIVEP2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HIVEP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HIVEP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 143054    OMIM disorders: --

    6 diseases for HIVEP2:    About MalaCards
    chronic myeloid leukemia    myeloid leukemia    leukemia    prostate cancer
    prostatitis    breast cancer


    HIVEP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for HIVEP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 2022670 (1)
    cancer 0 1 15805119 (1)

    Genetic Association Database (GAD): HIVEP2

    Export disorders for HIVEP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIVEP2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with HIVEP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1. (PubMed id 2022670)1, 2, 3, 9 Nomura N....Ishii S. (1991)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Specific activation of SSTR-2 promoter by SEF-2 and MIBP-1. (PubMed id 10207097)1, 2 Doerflinger U....Buettner R. (1999)
    5. Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24. (PubMed id 1733857)1, 3 Sudo T....Ishii S. (1992)
    6. Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes. (PubMed id 1409593)1, 2 Van't Veer L.J.... Bernards R. (1992)
    7. Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties. (PubMed id 2247438)1, 2 Rustgi A.K.... Bernards R. (1990)
    8. Genome-wide repression of NF-kB target genes by transc ription factor MIBP1 and its modulation by O-linked b-N-acetylglucosamine (O-Glc NAc) transferase. (PubMed id 22294689)1 Iwashita Y....Tahira T. (2012)
    9. Nucleophosmin deposition during mRNA 3' end processin g influences poly(A) tail length. (PubMed id 21822216)1 Sagawa F....Wilusz J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3097 HGNC: 4921 AceView: HIVEP2 Ensembl:ENSG00000010818 euGenes: HUgn3097
    ECgene: HIVEP2 H-InvDB: HIVEP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIVEP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIVEP2 gene:
    Search GeneIP for patents involving HIVEP2

    GeneCards and IP:
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