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Aliases for HIVEP2 Gene

Aliases for HIVEP2 Gene

  • Human Immunodeficiency Virus Type I Enhancer Binding Protein 2 2 3 5
  • Human Immunodeficiency Virus Type I Enhancer-Binding Protein 2 2 3 4
  • C-Myc Intron Binding Protein 1 2 3
  • MHC-Binding Protein 2 3 4
  • HIV-EP2 3 4
  • MBP-2 3 4
  • MHC Binding Protein-2 3
  • Schnurri-2 3
  • ZNF40B 3
  • MIBP1 3
  • SHN2 3
  • ZAS2 3

External Ids for HIVEP2 Gene

Previous GeneCards Identifiers for HIVEP2 Gene

  • GC06M142919
  • GC06M143053
  • GC06M143114
  • GC06M140638
  • GC06M143072

Summaries for HIVEP2 Gene

Entrez Gene Summary for HIVEP2 Gene

  • This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]

GeneCards Summary for HIVEP2 Gene

HIVEP2 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 2) is a Protein Coding gene. An important paralog of this gene is HIVEP1.

UniProtKB/Swiss-Prot for HIVEP2 Gene

  • This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.

Gene Wiki entry for HIVEP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIVEP2 Gene

Genomics for HIVEP2 Gene

Regulatory Elements for HIVEP2 Gene

Promoters for HIVEP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIVEP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HIVEP2 Gene

Chromosome:
6
Start:
142,751,467 bp from pter
End:
142,945,201 bp from pter
Size:
193,735 bases
Orientation:
Minus strand

Genomic View for HIVEP2 Gene

Genes around HIVEP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIVEP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIVEP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIVEP2 Gene

Proteins for HIVEP2 Gene

  • Protein details for HIVEP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31629-ZEP2_HUMAN
    Recommended name:
    Transcription factor HIVEP2
    Protein Accession:
    P31629
    Secondary Accessions:
    • Q02646
    • Q5THT5
    • Q9NS05

    Protein attributes for HIVEP2 Gene

    Size:
    2446 amino acids
    Molecular mass:
    269053 Da
    Quaternary structure:
    • Interacts with TCF4.
    SequenceCaution:
    • Sequence=AAB88218.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46596.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HIVEP2 Gene

Proteomics data for HIVEP2 Gene at MOPED

Post-translational modifications for HIVEP2 Gene

  • Ubiquitination at Lys 2092
  • Modification sites at PhosphoSitePlus

Other Protein References for HIVEP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIVEP2 Gene

Domains & Families for HIVEP2 Gene

Gene Families for HIVEP2 Gene

Protein Domains for HIVEP2 Gene

Suggested Antigen Peptide Sequences for HIVEP2 Gene

Graphical View of Domain Structure for InterPro Entry

P31629

UniProtKB/Swiss-Prot:

ZEP2_HUMAN :
  • Contains 4 C2H2-type zinc fingers.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HIVEP2: view

Function for HIVEP2 Gene

Molecular function for HIVEP2 Gene

GENATLAS Biochemistry:
human immunodeficiency virus type 1, enhancer binding protein
UniProtKB/Swiss-Prot Function:
This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
UniProtKB/Swiss-Prot Induction:
By mitogens and phorbol ester.

Gene Ontology (GO) - Molecular Function for HIVEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with HIVEP2: view
genes like me logo Genes that share phenotypes with HIVEP2: view

Animal Models for HIVEP2 Gene

MGI Knock Outs for HIVEP2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIVEP2 Gene

Localization for HIVEP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIVEP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIVEP2 Gene COMPARTMENTS Subcellular localization image for HIVEP2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HIVEP2 Gene

Pathways & Interactions for HIVEP2 Gene

SuperPathways for HIVEP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIVEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with HIVEP2: view

No data available for Pathways by source and SIGNOR curated interactions for HIVEP2 Gene

Drugs & Compounds for HIVEP2 Gene

No Compound Related Data Available

Transcripts for HIVEP2 Gene

mRNA/cDNA for HIVEP2 Gene

Unigene Clusters for HIVEP2 Gene

Human immunodeficiency virus type I enhancer binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIVEP2 Gene

No ASD Table

Relevant External Links for HIVEP2 Gene

GeneLoc Exon Structure for
HIVEP2
ECgene alternative splicing isoforms for
HIVEP2

Expression for HIVEP2 Gene

mRNA expression in normal human tissues for HIVEP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIVEP2 Gene

This gene is overexpressed in Nasal epithelium (62.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIVEP2 Gene



SOURCE GeneReport for Unigene cluster for HIVEP2 Gene Hs.510172

mRNA Expression by UniProt/SwissProt for HIVEP2 Gene

P31629-ZEP2_HUMAN
Tissue specificity: Expressed in brain and skeletal muscle.
genes like me logo Genes that share expression patterns with HIVEP2: view

Protein tissue co-expression partners for HIVEP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HIVEP2 Gene

Orthologs for HIVEP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIVEP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIVEP2 35
  • 87.9 (n)
  • 90.23 (a)
HIVEP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIVEP2 35
  • 90.75 (n)
  • 92.55 (a)
HIVEP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hivep2 35
  • 85.37 (n)
  • 87.93 (a)
Hivep2 16
Hivep2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIVEP2 35
  • 99.63 (n)
  • 99.63 (a)
HIVEP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hivep2 35
  • 85.32 (n)
  • 88 (a)
oppossum
(Monodelphis domestica)
Mammalia HIVEP2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIVEP2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves HIVEP2 35
  • 74.45 (n)
  • 74.22 (a)
HIVEP2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hivep2 35
  • 65.82 (n)
  • 62.45 (a)
Str.13398 35
zebrafish
(Danio rerio)
Actinopterygii hivep2a 35
  • 56.73 (n)
  • 52.07 (a)
HIVEP2 (1 of 2) 36
  • 41 (a)
OneToMany
hivep2a 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta shn 37
  • 41 (a)
shn 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-9 36
  • 12 (a)
OneToMany
Species with no ortholog for HIVEP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIVEP2 Gene

ENSEMBL:
Gene Tree for HIVEP2 (if available)
TreeFam:
Gene Tree for HIVEP2 (if available)

Paralogs for HIVEP2 Gene

Paralogs for HIVEP2 Gene

(9) SIMAP similar genes for HIVEP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIVEP2: view

Variants for HIVEP2 Gene

Sequence variations from dbSNP and Humsavar for HIVEP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17072013 - 142,774,602(+) GTTGC(C/T)GCTGT reference, missense
rs34875559 - 142,771,617(-) CCCAG(C/T)GGAAG reference, missense
rs35675714 - 142,770,862(-) AGAAC(A/C/T)TTCTT reference, missense
rs109836 - 142,770,126(-) ATTCC(C/T)GCCCA reference, missense
rs3383 -- 142,751,904(+) CCATC(C/T)CCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HIVEP2 Gene

Variant ID Type Subtype PubMed ID
nsv830828 CNV Gain 17160897
nsv830829 CNV Loss 17160897
nsv520992 CNV Loss 19592680
esv2732809 CNV Deletion 23290073
esv2732810 CNV Deletion 23290073
esv2732811 CNV Deletion 23290073
esv2130804 CNV Deletion 18987734
esv2732812 CNV Deletion 23290073
dgv1068e201 CNV Deletion 23290073
esv2732814 CNV Deletion 23290073
esv2732816 CNV Deletion 23290073
esv6993 CNV Gain 19470904
esv5938 CNV Gain 19470904
nsv819036 CNV Loss 19587683
dgv1158e199 CNV Deletion 23128226

Variation tolerance for HIVEP2 Gene

Residual Variation Intolerance Score: 1.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIVEP2 Gene

HapMap Linkage Disequilibrium report
HIVEP2
Human Gene Mutation Database (HGMD)
HIVEP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIVEP2 Gene

Disorders for HIVEP2 Gene

Relevant External Links for HIVEP2

Genetic Association Database (GAD)
HIVEP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIVEP2

No disorders were found for HIVEP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIVEP2 Gene

Publications for HIVEP2 Gene

  1. HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1. (PMID: 2022670) Nomura N. … Ishii S. (J. Biol. Chem. 1991) 2 3 4 23 67
  2. Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24. (PMID: 1733857) Sudo T. … Ishii S. (Genomics 1992) 2 3
  3. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. DNA Damage Regulates Translation through I^-TRCP Targeting of CReP. (PMID: 26091241) Loveless T.B. … Toczyski D.P. (PLoS Genet. 2015) 3

Products for HIVEP2 Gene

Sources for HIVEP2 Gene

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