Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIVEP2 Gene

protein-coding   GIFtS: 55
GCID: GC06M143072

Human Immunodeficiency Virus Type I Enhancer Binding Protein...

(Previous name: human immunodeficiency virus type I enhancer-binding protein...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Human Immunodeficiency Virus Type I Enhancer Binding Protein 21 2     SHN22
Human Immunodeficiency Virus Type I Enhancer-Binding Protein 21 2 3     Schnurri-22
C-Myc Intron Binding Protein 11 2     ZAS22
HIV-EP22 3     ZNF40B2
MBP-22 3     MHC Binding Protein-22
MHC-Binding Protein 22 3     Transcription Factor HIVEP22
MIBP12     

External Ids:    HGNC: 49211   Entrez Gene: 30972   Ensembl: ENSG000000108187   OMIM: 1430545   UniProtKB: P316293   

Export aliases for HIVEP2 gene to outside databases

Previous GC identifers: GC06M142695 GC06M142919 GC06M143053 GC06M143114 GC06M140638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIVEP2 Gene:
This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors.
The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes
that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two
widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a
serine/threonine-rich sequence. (provided by RefSeq, Nov 2012)

GeneCards Summary for HIVEP2 Gene:
HIVEP2 (human immunodeficiency virus type I enhancer binding protein 2) is a protein-coding gene. An important paralog of this gene is HIVEP1.

UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer
elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are
found in the enhancer elements of a number of cellular promoters, including those of the class I MHC,
interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation

Gene Wiki entry for HIVEP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIVEP2 gene promoter:
         USF1   GATA-3   CUTL1   IRF-1   Ik-3   S8   E2F-1   USF-1   Zic3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIVEP2 promoter sequence
   Search Chromatin IP Primers for HIVEP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIVEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q24.2   HGNC cytogenetic band: 6q23-q24

HIVEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIVEP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M143072:  view genomic region     (about GC identifiers)

Start:
143,072,604 bp from pter      End:
143,266,338 bp from pter
Size:
193,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629 (See protein sequence)
Recommended Name: Transcription factor HIVEP2  
Size: 2446 amino acids; 269053 Da
Subunit: Interacts with TCF4 (By similarity)
Sequence caution: Sequence=AAB88218.1; Type=Erroneous initiation; Sequence=CAA46596.1; Type=Erroneous initiation;
Secondary accessions: Q02646 Q5THT5 Q9NS05

Explore the universe of human proteins at neXtProt for HIVEP2: NX_P31629

Explore proteomics data for HIVEP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys2092
  • Modification sites at PhosphoSitePlus

  • See HIVEP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006725.3  
    ENSEMBL proteins: 
     ENSP00000356576   ENSP00000012134   ENSP00000356575  

    HIVEP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HIVEP2
    GenScript Custom Purified and Recombinant Proteins Services for HIVEP2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIVEP2

     
    Search eBioscience for Proteins for HIVEP2 

    HIVEP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HIVEP2
    OriGene Custom Antibody Services for HIVEP2
    Novus Biologicals HIVEP2 Antibody
    Abcam antibodies for HIVEP2
    Cloud-Clone Corp. Antibodies for HIVEP2
    Search ThermoFisher Antibodies for HIVEP2
    LSBio Antibodies in human, mouse, rat for HIVEP2

    HIVEP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIVEP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIVEP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIVEP2
    Cloud-Clone Corp. CLIAs for HIVEP2
    Search eBioscience for ELISAs for HIVEP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P31629

    ProtoNet protein and cluster: P31629

    UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with HIVEP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZEP2_HUMAN, P31629
    Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer
    elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are
    found in the enhancer elements of a number of cellular promoters, including those of the class I MHC,
    interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation
    Induction: By mitogens and phorbol ester

         Genatlas biochemistry entry for HIVEP2:
    human immunodeficiency virus type 1, enhancer binding protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS2022670
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with HIVEP2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HIVEP2:
     Increased S DNA content  Increased cell size  S arrest 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hivep2):
     hematopoietic system  immune system 

    Find genes that share phenotypes with HIVEP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hivep2tm1Sis for HIVEP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIVEP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIVEP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIVEP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIVEP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIVEP2:
    hsa-mir-130b-3p (MIRT020335), hsa-mir-484 (MIRT041806), hsa-mir-155-5p (MIRT000974), hsa-mir-598-3p (MIRT040488)

    Block miRNA regulation of human, mouse, rat HIVEP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIVEP2 (see all 111):
    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidHIVEP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIVEP2
    Predesigned siRNA for gene silencing in human, mouse, rat HIVEP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIVEP2

    Clone
    Products:
         
    OriGene clones in human, mouse for HIVEP2 (see all 5)
    OriGene ORF clones in mouse, rat for HIVEP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIVEP2 (NM_006734)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIVEP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIVEP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZEP2_HUMAN, P31629: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with HIVEP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIVEP2
    Interactions:

        Search GeneGlobe Interaction Network for HIVEP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIVEP2 (P316292, 3 ENSP000000121344) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with HIVEP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIVEP2 (ZEP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIVEP2 gene: 
    NM_006734.3  

    Unigene Cluster for HIVEP2:

    Human immunodeficiency virus type I enhancer binding protein 2
    Hs.510172  [show with all ESTs]
    Unigene Representative Sequence: NM_006734
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367604 ENST00000012134 ENST00000474532 ENST00000367603(uc003qjd.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIVEP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIVEP2 (see all 111):
    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-605 hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidHIVEP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIVEP2
    Predesigned siRNA for gene silencing in human, mouse, rat HIVEP2
    Clone
    Products:
         
    OriGene clones in human, mouse for HIVEP2 (see all 5)
    OriGene ORF clones in mouse, rat for HIVEP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIVEP2 (NM_006734)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HIVEP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIVEP2
      QuantiTect SYBR Green Assays in human, mouse, rat HIVEP2
      QuantiFast Probe-based Assays in human, mouse, rat HIVEP2

    Additional mRNA sequence: 

    AK226163.1 AK296531.1 BC032679.1 CR936782.1 DQ231041.1 M61744.1 X65644.1 

    5 DOTS entries:

    DT.99939994  DT.317616  DT.95168479  DT.204400  DT.92333502 

    Selected AceView cDNA sequences (see all 131):

    AA557381 X65644 F07489 AL597327 AW779787 BP335214 AL698286 M61744 
    NM_006734 AW439617 T29332 AA033892 BQ717297 BQ018752 BU428863 BP361240 
    BM975390 N45264 BM468942 AI684058 F02143 CA503382 AW628113 AA244493 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIVEP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIVEP2 Expression
    About this image


    HIVEP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Subcutaneous White Preadipocytes Body Subcutaneous White Adipose
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Brain (Nervous System)
             Cerebral Cortex
    HIVEP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIVEP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510172

    UniProtKB/Swiss-Prot: ZEP2_HUMAN, P31629
    Tissue specificity: Expressed in brain and skeletal muscle

        Custom PCR Arrays for HIVEP2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HIVEP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIVEP2
    QuantiTect SYBR Green Assays in human, mouse, rat HIVEP2
    QuantiFast Probe-based Assays in human, mouse, rat HIVEP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HIVEP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hivep21 , 5 human immunodeficiency virus type I enhancer binding more1, 5 85.37(n)1
    87.93(a)1
      10 (5.14 cM)5
    152731  NM_010437.21  NP_034567.21 
     139663795 
    chicken
    (Gallus gallus)
    Aves HIVEP21 human immunodeficiency virus type I enhancer binding more 74.45(n)
    74.22(a)
      421672  XM_004935681.1  XP_004935738.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    69(a)
    68(a)
    1 ↔ many
    1 ↔ many
    1(203410572-203423204)
    1(203441314-203448161)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW158907.12   -- 80.19(n)    AW158907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hivep2a1 human immunodeficiency virus type I enhancer binding more 56.73(n)
    52.07(a)
      562048  NM_001030164.1  NP_001025335.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shn3 wing morphogenesis transcription factor 41(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea sma-96
    Protein SMA-9, isoform i
    12(a)
    1 → many
    X(10769288-10782962) WBGene00004862


    ENSEMBL Gene Tree for HIVEP2 (if available)
    TreeFam Gene Tree for HIVEP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIVEP2 gene
    HIVEP12  ZNF8312  HIVEP32  
    9 SIMAP similar genes for HIVEP2 using alignment to 1 protein entry:     ZEP2_HUMAN:
    MIBP1    KBP-1    DKFZp434J0650    ZNF844    ZNF    HZF16
    ZNF78L1    A-328A3.4    kr-znf3

    Find genes that share paralogs with HIVEP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIVEP2 (see all 3706)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452324071,2
    C--143072187(+) GATTTA/GTGGGT 1 -- ds50010--------
    rs1929950121,2
    --143072223(+) CTTAGC/TTTCAG 1 -- ds50010--------
    rs780599591,2
    C,F--143072266(+) CAGTGG/AAATTT 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs5764201,2
    C,F,O,H--143072350(+) GCAACG/ATATGC 1 -- ds500131Minor allele frequency- A:0.09NA NS EA WA CSA 3328
    rs1398051411,2
    C--143072417(+) GACCA-/CTAT  
            
    CTGTT
    1 -- ds50010--------
    rs1848487941,2
    --143072588(+) AACACA/TTAAGA 1 -- ds50010--------
    rs735824681,2
    C,F--143072771(+) CTGCAC/TCCCTC 1 -- ut312Minor allele frequency- T:0.03WA 120
    rs767348241,2
    C,F--143072873(+) TCCCAC/GGAGTT 1 -- ut311Minor allele frequency- G:0.19WA 118
    rs1136525811,2
    C,F--143072909(+) CCATTC/TCCCCT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs1435303871,2
    C--143072949(+) CTATG-/AAAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HIVEP2 (143072604 - 143266338 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HIVEP2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732816CNV Deletion23290073
    esv2732812CNV Deletion23290073
    esv2732811CNV Deletion23290073
    esv2732809CNV Deletion23290073
    dgv1158e199CNV Deletion23128226
    esv2732810CNV Deletion23290073
    esv2130804CNV Deletion18987734
    dgv1068e201CNV Deletion23290073
    esv2732814CNV Deletion23290073
    nsv830829CNV Loss17160897

    Human Gene Mutation Database (HGMD): HIVEP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIVEP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HIVEP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 143054    OMIM disorders: --


    Find genes that share disorders with HIVEP2           About GenesLikeMe

    2 Novoseek inferred disease relationships for HIVEP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 2022670 (1)
    cancer 0 1 15805119 (1)

    Genetic Association Database (GAD): HIVEP2

    Export disorders for HIVEP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIVEP2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with HIVEP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1. (PubMed id 2022670)1, 2, 3, 9 Nomura N....Ishii S. (J. Biol. Chem. 1991)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. (PubMed id 10207097)1, 2 Doerflinger U....Buettner R. (Mol. Cell. Biol. 1999)
    5. Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24. (PubMed id 1733857)1, 3 Sudo T....Ishii S. (Genomics 1992)
    6. Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes. (PubMed id 1409593)1, 2 Van't Veer L.J.... Bernards R. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    7. Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties. (PubMed id 2247438)1, 2 Rustgi A.K.... Bernards R. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    8. Genome-wide repression of NF-I_B target genes by transcription factor MIBP1 and its modulation by O-linked I^-N-acetylglucosamine (O-GlcNAc) transferase. (PubMed id 22294689)1 Iwashita Y....Tahira T. (J. Biol. Chem. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length. (PubMed id 21822216)1 Sagawa F....Wilusz J. (EMBO J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3097 HGNC: 4921 AceView: HIVEP2 Ensembl:ENSG00000010818 euGenes: HUgn3097
    ECgene: HIVEP2 H-InvDB: HIVEP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIVEP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIVEP2 gene:
    Search GeneIP for patents involving HIVEP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HIVEP2   OriGene RNAi products in human, mouse, rat for HIVEP2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HIVEP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIVEP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HIVEP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIVEP2   OriGene Custom Protein Services for HIVEP2  

     
     
     Block miRNA regulation of human, mouse, rat HIVEP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIVEP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIVEP2 Predesigned siRNA for gene silencing in human, mouse, rat HIVEP2
     QuantiFast Probe-based Assays in human, mouse, rat HIVEP2 QuantiTect SYBR Green Assays in human, mouse, rat HIVEP2
     Custom PCR Arrays for HIVEP2 Search Chromatin IP Primers for HIVEP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIVEP2  Search GeneGlobe Interaction Network for HIVEP2
     Regulatory tfbs in HIVEP2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIVEP2 GenScript cDNA clones with any tag delivered in your preferred vector for HIVEP2
     GenScript Custom Assay Services for HIVEP2 GenScript Custom overexpressing Cell Line Services for HIVEP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HIVEP2 (ZEP2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HIVEP2 antibodies
     Antibodies for HIVEP2
     See all of Abcam's Antibodies, Kits and Proteins for HIVEP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIVEP2
     Antibodies for HIVEP2
     ELISAs for HIVEP2
     CLIAs for HIVEP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIVEP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP2
     SwitchGear 3'UTR luciferase reporter plasmids for HIVEP2
     SwitchGear Promoter luciferase reporter plasmids for HIVEP2
     Search ThermoFisher Antibodies for HIVEP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIVEP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIVEP2
     LSBio Antibodies in human, mouse, rat for HIVEP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for HIVEP2
      Search eBioscience for proteins for HIVEP2
      Search eBioscience for elisas for HIVEP2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIVEP2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4