Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIVEP1 Gene

Aliases for HIVEP1 Gene

  • Human Immunodeficiency Virus Type I Enhancer Binding Protein 1 2 3
  • ZNF40 3 4 6
  • Human Immunodeficiency Virus Type I Enhancer-Binding Protein 1 2 4
  • Gate Keeper Of Apoptosis-Activating Protein 3 4
  • Cirhin Interaction Protein 3 4
  • Zinc Finger Protein 40 2 3
  • PRDII-BF1 3 4
  • MBP-1 3 4
  • CIRIP 3 4
  • GAAP 3 4
  • Major Histocompatibility Complex Binding Protein 1 3
  • Major Histocompatibility Complex-Binding Protein 1 4
  • Positive Regulatory Domain II Binding Factor 1 3
  • Positive Regulatory Domain II-Binding Factor 1 4
  • Schnurri-1 3
  • HIV-EP1 4
  • CRYBP1 3
  • ZNF40A 3
  • ZAS1 3

External Ids for HIVEP1 Gene

Previous HGNC Symbols for HIVEP1 Gene

  • ZNF40

Previous GeneCards Identifiers for HIVEP1 Gene

  • GC06P012070
  • GC06P012120
  • GC06P011947

Summaries for HIVEP1 Gene

Entrez Gene Summary for HIVEP1 Gene

  • This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]

GeneCards Summary for HIVEP1 Gene

HIVEP1 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 1) is a Protein Coding gene. An important paralog of this gene is ZNF831.

UniProtKB/Swiss-Prot for HIVEP1 Gene

  • This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis

Gene Wiki entry for HIVEP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIVEP1 Gene

Genomics for HIVEP1 Gene

Regulatory Elements for HIVEP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIVEP1 Gene

Start:
12,008,762 bp from pter
End:
12,229,791 bp from pter
Size:
221,030 bases
Orientation:
Plus strand

Genomic View for HIVEP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIVEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIVEP1 Gene

Proteins for HIVEP1 Gene

  • Protein details for HIVEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15822-ZEP1_HUMAN
    Recommended name:
    Zinc finger protein 40
    Protein Accession:
    P15822
    Secondary Accessions:
    • B2RTU3
    • Q14122
    • Q5MPB1
    • Q5VW60

    Protein attributes for HIVEP1 Gene

    Size:
    2718 amino acids
    Molecular mass:
    296865 Da
    Quaternary structure:
    • Interacts with CIRH1A.
    SequenceCaution:
    • Sequence=CAA35798.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAH73909.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14768.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21070.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIVEP1 Gene

    Alternative splice isoforms for HIVEP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIVEP1 Gene

Proteomics data for HIVEP1 Gene at MOPED

Post-translational modifications for HIVEP1 Gene

  • Ubiquitination at Lys661
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HIVEP1 Gene

Domains for HIVEP1 Gene

Gene Families for HIVEP1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for HIVEP1 Gene

Suggested Antigen Peptide Sequences for HIVEP1 Gene

Graphical View of Domain Structure for InterPro Entry

P15822

UniProtKB/Swiss-Prot:

ZEP1_HUMAN :
  • P15822
Domain:
  • Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HIVEP1: view

Function for HIVEP1 Gene

Molecular function for HIVEP1 Gene

GENATLAS Biochemistry: human immunodeficiency virus type I enhancer binding protein 1,MHC binding protein 1,positive regulatory domain II binding (HIV - EP1/MBP1/PRDII - BF1)
UniProtKB/Swiss-Prot Function: This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis
UniProtKB/Swiss-Prot Induction: By mitogens and phorbol ester

Gene Ontology (GO) - Molecular Function for HIVEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16713569
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HIVEP1: view

Phenotypes for HIVEP1 Gene

MGI mutant phenotypes for HIVEP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for HIVEP1:
genes like me logo Genes that share phenotypes with HIVEP1: view

Animal Models for HIVEP1 Gene

MGI Knock Outs for HIVEP1:

Animal Model Products

CRISPR Products

miRNA for HIVEP1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIVEP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HIVEP1 Gene

Localization for HIVEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIVEP1 Gene

Isoform 1: Nucleus.
Isoform 2: Cytoplasm. Nucleus.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIVEP1 Gene COMPARTMENTS Subcellular localization image for HIVEP1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for HIVEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with HIVEP1: view

Pathways for HIVEP1 Gene

SuperPathways for HIVEP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIVEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with HIVEP1: view

No data available for Pathways by source for HIVEP1 Gene

Compounds for HIVEP1 Gene

(1) Novoseek inferred chemical compound relationships for HIVEP1 Gene

Compound -log(P) Hits PubMed IDs
zinc 60.2 9
genes like me logo Genes that share compounds with HIVEP1: view

Transcripts for HIVEP1 Gene

Unigene Clusters for HIVEP1 Gene

Human immunodeficiency virus type I enhancer binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIVEP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIVEP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIVEP1 Gene

No ASD Table

Relevant External Links for HIVEP1 Gene

GeneLoc Exon Structure for
HIVEP1
ECgene alternative splicing isoforms for
HIVEP1

Expression for HIVEP1 Gene

mRNA expression in normal human tissues for HIVEP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIVEP1 Gene

SOURCE GeneReport for Unigene cluster for HIVEP1 Gene Hs.567284

genes like me logo Genes that share expressions with HIVEP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIVEP1 Gene

Orthologs for HIVEP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIVEP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIVEP1 35
  • 99.29 (n)
  • 98.75 (a)
HIVEP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIVEP1 35
  • 75.77 (n)
  • 72.76 (a)
HIVEP1 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIVEP1 35
  • 82.75 (n)
  • 80.36 (a)
HIVEP1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hivep1 35
  • 76.84 (n)
  • 72.26 (a)
Hivep1 16
Hivep1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HIVEP1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIVEP1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hivep1 35
  • 76.12 (n)
  • 71.53 (a)
chicken
(Gallus gallus)
Aves HIVEP1 35
  • 66.72 (n)
  • 61.3 (a)
HIVEP1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIVEP1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hivep1 35
  • 59.33 (n)
  • 52.91 (a)
Str.7401 35
zebrafish
(Danio rerio)
Actinopterygii hivep1 35
  • 55.6 (n)
  • 49.98 (a)
hivep1 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shn 36
  • 16 (a)
OneToMany
shn 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea sma-9 36
  • 14 (a)
OneToMany
Species with no ortholog for HIVEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIVEP1 Gene

ENSEMBL:
Gene Tree for HIVEP1 (if available)
TreeFam:
Gene Tree for HIVEP1 (if available)

Paralogs for HIVEP1 Gene

Paralogs for HIVEP1 Gene

genes like me logo Genes that share paralogs with HIVEP1: view

Variants for HIVEP1 Gene

Sequence variations from dbSNP and Humsavar for HIVEP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs12014 -- 12,119,992(+) ATCCC(A/C)ACTGA missense, reference, nc-transcript-variant
rs140709 -- 12,213,180(+) AACAT(-/TAT)GAGAT intron-variant
rs140810 -- 12,208,889(+) CCTAT(-/CTGA)CTAAT intron-variant
rs140815 -- 12,194,056(+) GAGAT(-/GTGCAGTAA)GTTCA intron-variant
rs219938 -- 12,137,774(+) GTGTA(A/G)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIVEP1 Gene

Variant ID Type Subtype PubMed ID
esv22880 CNV Gain+Loss 19812545
esv2662717 CNV Deletion 23128226
esv2656995 CNV Deletion 23128226
esv2677354 CNV Deletion 23128226
esv2670070 CNV Deletion 23128226
esv273428 CNV Insertion 20981092
esv268157 CNV Insertion 20981092
nsv509116 CNV Insertion 20534489
nsv830586 CNV Gain 17160897

Relevant External Links for HIVEP1 Gene

HapMap Linkage Disequilibrium report
HIVEP1
Human Gene Mutation Database (HGMD)
HIVEP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIVEP1 Gene

Disorders for HIVEP1 Gene

(1) Novoseek inferred disease relationships for HIVEP1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 37.6 2

Relevant External Links for HIVEP1

Genetic Association Database (GAD)
HIVEP1
Human Genome Epidemiology (HuGE) Navigator
HIVEP1
genes like me logo Genes that share disorders with HIVEP1: view

No data available for UniProtKB/Swiss-Prot for HIVEP1 Gene

Publications for HIVEP1 Gene

  1. High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1. (PMID: 1567844) Omichinski J.G. … Gronenborn A.M. (Biochemistry 1992) 3 4 23
  2. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. (PMID: 1727488) Muchardt C. … Gaynor R.B. (J. Virol. 1992) 3 4 23
  3. Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24. (PMID: 2037300) Gaynor R.B. … Lusis A.J. (Genomics 1991) 2 3 23
  4. A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. (PMID: 2108316) Baldwin A.S. Jr. … Sharp P.A. (Mol. Cell. Biol. 1990) 3 4 23
  5. Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1. (PMID: 19732766) Yu B. … Richter A. (Exp. Cell Res. 2009) 3 4 23

Products for HIVEP1 Gene

Sources for HIVEP1 Gene

Back to Top

Content