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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIVEP1 Gene

protein-coding   GIFtS: 52
GCID: GC06P012009

human immunodeficiency virus type I enhancer binding protein...

(Previous names: human immunodeficiency virus type I enhancer-binding protein...)
(Previous symbol: ZNF40)
 Explore 9 diseases affiliated with
HIVEP1 via
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 Human Malady Compendium 
Biological research products
for HIVEP1    

Aliases
for HIVEP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Human Immunodeficiency Virus Type I Enhancer Binding Protein 11 2     Zinc Finger Protein 401 2
ZNF401 2 3 5     Cirhin Interaction Protein2 3
Human Immunodeficiency Virus Type I Enhancer-Binding Protein 11 2 3     Gate Keeper Of Apoptosis-Activating Protein2 3
CIRIP1 2 3     Major Histocompatibility Complex-Binding Protein 12 3
MBP-11 2 3     Positive Regulatory Domain II-Binding Factor 12 3
PRDII-BF11 2 3     GAAP2 3
CRYBP11 2     HIV-EP12 3
Schnurri-11 2     Major Histocompatibility Complex Binding Protein 12
ZAS11 2     Positive Regulatory Domain II Binding Factor 12
ZNF40A1 2     Zinc Finger Protein 40 (Human Immunodeficiency Virus Type I Enhancer-Binding
Protein 1) (HIV-EP1) (Major Histocompatibility Complex Binding Protein 1)
(MBP-1) (Positive Regulatory Domain II Binding Factor 1) (PRDII-BF1)2

External Ids:    HGNC: 49201   Entrez Gene: 30962   Ensembl: ENSG000000959517   OMIM: 1945405   UniProtKB: P158223   

Export aliases for HIVEP1 gene to outside databases

Previous GC identifers: GC06P012070 GC06P012120 GC06P011947


Summaries
for HIVEP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIVEP1:
This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain
a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a
serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the
enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences
found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif,
suggesting a role in the transcriptional regulation of both viral and cellular genes. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: ZEP1_HUMAN, P15822
Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements
of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the
enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and
interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and
isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon
regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not
activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis

Gene Wiki entry for HIVEP1


Genomic Views
for HIVEP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIVEP1 gene promoter:
         TBP   RFX1   LCR-F1   Evi-1   YY1   STAT3   IRF-7A   Pax-4a   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIVEP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIVEP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24-p22.3   Ensembl cytogenetic band:  6p24.1   HGNC cytogenetic band: 6p24-p22.3

HIVEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIVEP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P012009:  view genomic region     (about GC identifiers)

Start:
 12,008,995 bp from pter      End:
 12,165,232 bp from pter
Size:
 156,238 bases      Orientation:
 plus strand

Proteins
for HIVEP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZEP1_HUMAN, P15822 (See protein sequence)
Recommended Name: Zinc finger protein 40  
Size: 2718 amino acids; 296865 Da
Subunit: Interacts with CIRH1A
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 2: Cytoplasm. Nucleus
Subcellular location: Isoform 3: Cytoplasm. Nucleus
Sequence caution: Sequence=CAA35798.1; Type=Frameshift; Positions=Several; Sequence=CAH73909.1; Type=Erroneous gene
model prediction; Sequence=CAH73982.1; Type=Erroneous gene model prediction; Sequence=CAI14768.1; Type=Erroneous gene
model prediction; Sequence=CAI21070.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for HIVEP1:
1BBO (3D)        3ZNF (3D)        4ZNF (3D)    
Secondary accessions: B2RTU3 Q14122 Q5MPB1 Q5VW60
Alternative splicing: 3 isoforms:  P15822-1   P15822-2   P15822-3   

Explore the universe of human proteins at neXtProt for HIVEP1: NX_P15822

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15822

    • HIVEP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002105.2  
    ENSEMBL proteins: 
     ENSP00000419762   ENSP00000417348   ENSP00000368698   ENSP00000409078   ENSP00000418021  
     ENSP00000419721   ENSP00000382395   ENSP00000445617  

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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIVEP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19732766
    GO:0005737cytoplasm IEA--


    HIVEP1 for ontologies           About GeneDecksing



    HIVEP1 Antibody Products: 
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    Uscn Antibodies for HIVEP1
    Search ThermoFisher Antibodies for HIVEP1

    Assay Products for HIVEP1: 
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    Uscn ELISAs and CLIAs for HIVEP1

    Protein Domains /
    Families
    for HIVEP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIVEP1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P15822

    ProtoNet protein and cluster: P15822

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZEP1_HUMAN, P15822
    Domain: Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a
    fifth zinc-finger in-between
    Similarity: Contains 5 C2H2-type zinc fingers


    Function
    for HIVEP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZEP1_HUMAN, P15822
    Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements
    of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the
    enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and
    interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and
    isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon
    regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not
    activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis
    Induction: By mitogens and phorbol ester

         Genatlas biochemistry entry for HIVEP1:
    human immunodeficiency virus type I enhancer binding protein 1,MHC binding protein 1,positive regulatory domain II
    binding (HIV - EP1/MBP1/PRDII - BF1)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP1
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP1 (see all 33):
    hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-30d hsa-miR-374a hsa-miR-218 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: HIVEP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIVEP1 (see all 7)
    OriGene shRNA RFP: HIVEP1
    OriGene siRNA: HIVEP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIVEP1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP1 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP1 

    Cell Line
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    Search LifeMap BioReagents cell lines for HIVEP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    HIVEP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIVEP1:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for HIVEP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIVEP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for HIVEP1 (P158221, 2, 3 ENSP000003686984) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-722264,EBI-930964 MINT-2859527 MINT-2859546 MINT-2855879 MINT-2859565 MINT-2859584 I2D: score=3 STRING: ENSP00000244769
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2859508 I2D: score=3 STRING: ENSP00000400806
    SMAD3P840222, 3, ENSP000003329734MINT-61726 I2D: score=3 STRING: ENSP00000332973
    EMG1Q929792, 3MINT-65074 I2D: score=4 
    CACNA1AO005551, 3EBI-722264,EBI-766279 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent ----


    HIVEP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIVEP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIVEP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIVEP1
    1 Novoseek chemical compound relationship for HIVEP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 60.2 11 1567844 (2), 7650680 (1), 18287285 (1), 19732766 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about HIVEP1 / ZEP1 

    Transcripts
    for HIVEP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIVEP1 gene: 
    NM_002114.2  

    Unigene Cluster for HIVEP1:

    Human immunodeficiency virus type I enhancer binding protein 1
    Hs.567284  [show with all ESTs]
    Unigene Representative Sequence: X51435
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491710 ENST00000487103 ENST00000379388(uc003nac.3 uc011diq.2)
    ENST00000442081 ENST00000478545 ENST00000484210 ENST00000399469 ENST00000541134


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP1
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP1 (see all 33):
    hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-30d hsa-miR-374a hsa-miR-218 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: HIVEP1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIVEP1 (see all 7)
    OriGene shRNA RFP: HIVEP1
    OriGene siRNA: HIVEP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIVEP1
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    GenScript: all cDNA clones in your preferred vector: HIVEP1 (NM_002114)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIVEP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP1

    Additional cDNA sequence: 

    AK294338.1 AY673640.1 BC028111.2 BC140816.1 J05011.1 M32019.1 X51435.1 

    10 DOTS entries:

    DT.415700  DT.95244666  DT.415701  DT.415703  DT.91686138  DT.92421721  DT.121318317  DT.121318333 
    DT.40127623  DT.40131009 

    24/91 AceView cDNA sequences (see all 91):

    CF143584 BP350310 CF143583 BX097330 CA430819 AW291295 AI033710 AI971788 
    AW389765 BM699466 AW389740 AA399387 CF143585 AI017317 BU742602 BG679671 
    AA398086 N23133 AA563642 M32019 AI611687 AW628406 CD614069 N67788 

    GeneLoc Exon Structure


    Expression
    for HIVEP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIVEP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTATAGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HIVEP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIVEP1

    SOURCE GeneReport for Unigene cluster: Hs.567284
        SABiosciences Custom PCR Arrays for HIVEP1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP1

    Orthologs
    for HIVEP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HIVEP1 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HIVEP11 human immunodeficiency virus type I enhancer binding more 66.29(n)
    60.9(a)    		   420856  XM_418944.3  XP_418944.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HIVEP16
    		 --
    		 53(a)
    		 1 ↔ 1
    		 GL343209.1(3359925-3402840)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.74012 Transcribed sequence with weak similarity to protein more 76.31(n)    AL896199.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii hivep11 human immunodeficiency virus type I enhancer binding more 54.56(n)
    47.94(a)    		   100000517  XM_001340663.3  XP_001340699.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta shn3 wing morphogenesis transcription factor 38(a)     --


    ENSEMBL Gene Tree for HIVEP1 (if available)
    TreeFam Gene Tree for HIVEP1 (if available) 

    Paralogs
    for HIVEP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIVEP1 gene
    ZNF8312  HIVEP22  HIVEP32  
    11 SIMAP similar genes for HIVEP1 using alignment to 9 protein entries:     ZEP1_HUMAN (see all proteins):
    kr-znf3    KBP-1    ZNF844    DKFZp434J0650    ZNF    HZF16
    DKFZp686N0199    PLZF    ZNF78L1    ZNFN1A2    ZFS-6

    HIVEP1 for paralogs           About GeneDecksing



    Genomic Variants
    for HIVEP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2711 NCBI SNPs in HIVEP1 are shown (see all 2711)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs802607881,2
    		F,--12010736(+) GGGAAC/AAAAAC 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs28762541,2
    		H--12010816(+) AAGGGG/AAAACC 1 -- us2k1 trp34Minor allele frequency- A:0.00NS EA 418
    rs7494461,2
    		C,F,A,H,--12010820(+) GGAAAA/CCAGTT 1 -- us2k112Minor allele frequency- C:0.49EA NS NA WA CSA 547
    rs788257051,2
    		F,--12010839(+) TCAGGG/AATTTT 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1154164261,2
    		C,F,--12010853(+) TTTTTT/GGCATC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs761662461,2
    		F,--12010927(+) CTTGAG/TGTGGA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs69181911,2
    		C,H--12011217(+) TGTCAG/TGCTGG 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 420
    rs1381454431,2
    		--12011253(+) GCTTCC/GGCACT 1 -- us2k10--------
    rs759066321,2
    		F,--12011257(+) CGGCAC/ATGGGA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs15743431,2
    		C,--12011664(-) GCGGTT/AGGTCC 1 -- us2k13Minor allele frequency- A:0.03MN NA 306

    HapMap Linkage Disequilibrium report for HIVEP1 (12008995 - 12165232 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HIVEP1
         1 CNV: 69329

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    Disorders / Diseases
    for HIVEP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIVEP1 for disorders           About GeneDecksing

    OMIM gene information: 194540    OMIM disorders: --

    9 diseases for HIVEP1:    About MalaCards
    immunodeficiency    north american indian childhood cirrhosis    esophageal varix    macular degeneration
    thrombosis    ataxia    esophagitis    neuronitis
    venous thrombosis

    1 Novoseek disease relationship for HIVEP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 37.6 2 1727488 (1), 1694016 (1)

    Human Genome Epidemiology (HuGE) Navigator: HIVEP1 (3 documents)

    Export disorders for HIVEP1 gene to outside databases

    Publications
    for HIVEP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIVEP1 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with HIVEP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. (PubMed id 8289330)1, 2, 9 Seeler J.S.... Gaynor R.B. (1994)
    2. Cirhin up-regulates a canonical NF-kappaB element thr ough strong interaction with Cirip/HIVEP1. (PubMed id 19732766)1, 2, 9 Yu B....Richter A. (2009)
    3. High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1. (PubMed id 1567844)1, 2, 9 Omichinski J.G....Gronenborn A.M. (1992)
    4. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. (PubMed id 1727488)1, 2, 9 Muchardt C.... Gaynor R.B. (1992)
    5. Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24. (PubMed id 2037300)1, 3, 9 Gaynor R.B....Lusis A.J. (1991)
    6. A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. (PubMed id 2108316)1, 2, 9 Baldwin A.S. Jr.... Sharp P.A. (1990)
    7. A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. (PubMed id 2106471)1, 2 Fan C.M. and Maniatis T. (1990)
    8. High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. (PubMed id 2248949)1, 2 Omichinski J.G....Gronenborn A.M. (1990)
    9. Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. (PubMed id 1694016)1, 9 Nakamura T....Piatigorsky J. (1990)
    10. Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B. (PubMed id 7650680)1, 9 Otsuka M....Inoue J. (1995)

    External Searches for HIVEP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIVEP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3096 HGNC: 4920 AceView: HIVEP1 Ensembl:ENSG00000095951 euGenes: HUgn3096
    ECgene: HIVEP1 H-InvDB: HIVEP1

    Other Databases showing HIVEP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIVEP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIVEP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIVEP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIVEP1 gene:
    Search GeneIP for patents involving HIVEP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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