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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIVEP1 Gene

protein-coding   GIFtS: 55
GCID: GC06P012009

Human Immunodeficiency Virus Type I Enhancer Binding Protein...

(Previous names: human immunodeficiency virus type I enhancer-binding protein...)
(Previous symbol: ZNF40)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Human Immunodeficiency Virus Type I Enhancer Binding Protein 11 2     HIV-EP12 3
ZNF401 2 3 5     MBP-12 3
Human Immunodeficiency Virus Type I Enhancer-Binding Protein 11 2 3     PRDII-BF12 3
Zinc Finger Protein 401 2     CRYBP12
Cirhin Interaction Protein2 3     Schnurri-12
Gate Keeper Of Apoptosis-Activating Protein2 3     ZAS12
Major Histocompatibility Complex-Binding Protein 12 3     ZNF40A2
Positive Regulatory Domain II-Binding Factor 12 3     Major Histocompatibility Complex Binding Protein 12
CIRIP2 3     Positive Regulatory Domain II Binding Factor 12
GAAP2 3     Zinc Finger Protein 40 (Human Immunodeficiency Virus Type I
Enhancer-Binding Protein 1) (HIV-EP1) (Major Histocompatibility Complex
Binding Protein 1) (MBP-1) (Positive Regulatory Domain II Binding Factor
1) (PRDII-BF1)2

External Ids:    HGNC: 49201   Entrez Gene: 30962   Ensembl: ENSG000000959517   OMIM: 1945405   UniProtKB: P158223   

Export aliases for HIVEP1 gene to outside databases

Previous GC identifers: GC06P012070 GC06P012120 GC06P011947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIVEP1 Gene:
This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that
contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich
region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif,
GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus
(HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein
binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular
genes. (provided by RefSeq, Oct 2011)

GeneCards Summary for HIVEP1 Gene: 
HIVEP1 (human immunodeficiency virus type I enhancer binding protein 1) is a protein-coding gene. Diseases associated with HIVEP1 include esophageal varix, and north american indian childhood cirrhosis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is HIVEP2.

UniProtKB/Swiss-Prot: ZEP1_HUMAN, P15822
Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer
elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are
found in the enhancer elements of a number of cellular promoters, including those of the class I MHC,
interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1
gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the
promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of
these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in
apoptosis

Gene Wiki entry for HIVEP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIVEP1 gene promoter:
         TBP   RFX1   LCR-F1   Evi-1   YY1   STAT3   IRF-7A   Pax-4a   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIVEP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIVEP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24-p22.3   Ensembl cytogenetic band:  6p24.1   HGNC cytogenetic band: 6p24-p22.3

HIVEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIVEP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P012009:  view genomic region     (about GC identifiers)

Start:
12,008,995 bp from pter      End:
12,165,232 bp from pter
Size:
156,238 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZEP1_HUMAN, P15822 (See protein sequence)
Recommended Name: Zinc finger protein 40  
Size: 2718 amino acids; 296865 Da
Subunit: Interacts with CIRH1A
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 2: Cytoplasm. Nucleus
Subcellular location: Isoform 3: Cytoplasm. Nucleus
Sequence caution: Sequence=CAA35798.1; Type=Frameshift; Positions=Several; Sequence=CAH73909.1; Type=Erroneous
gene model prediction; Sequence=CAH73982.1; Type=Erroneous gene model prediction; Sequence=CAI14768.1;
Type=Erroneous gene model prediction; Sequence=CAI21070.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for HIVEP1:
1BBO (3D)        3ZNF (3D)        4ZNF (3D)    
Secondary accessions: B2RTU3 Q14122 Q5MPB1 Q5VW60
Alternative splicing: 3 isoforms:  P15822-1   P15822-2   P15822-3   

Explore the universe of human proteins at neXtProt for HIVEP1: NX_P15822

Explore proteomics data for HIVEP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15822

  • HIVEP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIVEP1 Protein Expression
    REFSEQ proteins: NP_002105.2  
    ENSEMBL proteins: 
     ENSP00000419762   ENSP00000417348   ENSP00000368698   ENSP00000409078   ENSP00000418021  
     ENSP00000419721   ENSP00000382395   ENSP00000445617  

    Human Recombinant Protein Products for HIVEP1: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HIVEP1
    GenScript Custom Purified and Recombinant Proteins Services for HIVEP1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIVEP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19732766
    GO:0005737cytoplasm IEA--

    HIVEP1 for ontologies           About GeneDecksing



    HIVEP1 Antibody Products: 
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    Abcam antibodies for HIVEP1
    Cloud-Clone Corp. Antibodies for HIVEP1 
    Search ThermoFisher Antibodies for HIVEP1
    LSBio Antibodies in human, mouse, rat for HIVEP1 

    Assay Products for HIVEP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIVEP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIVEP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIVEP1 
    Cloud-Clone Corp. CLIAs for HIVEP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P15822

    ProtoNet protein and cluster: P15822

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZEP1_HUMAN, P15822
    Domain: Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There
    is a fifth zinc-finger in-between
    Similarity: Contains 5 C2H2-type zinc fingers


    HIVEP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZEP1_HUMAN, P15822
    Function: This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer
    elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are
    found in the enhancer elements of a number of cellular promoters, including those of the class I MHC,
    interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1
    gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the
    promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of
    these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in
    apoptosis
    Induction: By mitogens and phorbol ester

         Genatlas biochemistry entry for HIVEP1:
    human immunodeficiency virus type I enhancer binding protein 1,MHC binding protein 1,positive regulatory domain II
    binding (HIV - EP1/MBP1/PRDII - BF1)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16713569
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    HIVEP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HIVEP1:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hivep1):
     no phenotypic analysis 

    HIVEP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hivep1tm1Sis for HIVEP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIVEP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIVEP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIVEP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIVEP1 

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP1 (see all 33):
    hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-30d hsa-miR-374a hsa-miR-218 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidHIVEP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIVEP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIVEP1


    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HIVEP1 (see all 5)
    OriGene ORF clones in mouse, rat for HIVEP1
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    GenScript: all cDNA clones in your preferred vector: HIVEP1 (NM_002114)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HIVEP1
    Search LifeMap BioReagents cell lines for HIVEP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIVEP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for HIVEP1 (P158221, 2, 3 ENSP000003686984) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-722264,EBI-930964 MINT-2859527 MINT-2859546 MINT-2855879 MINT-2859565 MINT-2859584 I2D: score=3 STRING: ENSP00000244769
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2859508 I2D: score=3 STRING: ENSP00000400806
    SMAD3P840222, 3, ENSP000003329734MINT-61726 I2D: score=3 STRING: ENSP00000332973
    EMG1Q929792, 3MINT-65074 I2D: score=4 
    CACNA1AO005551, 3EBI-722264,EBI-766279 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent ----

    HIVEP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIVEP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIVEP1 (ZEP1)

    1 Novoseek inferred chemical compound relationship for HIVEP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 60.2 11 1567844 (2), 7650680 (1), 18287285 (1), 19732766 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about HIVEP1 / ZEP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIVEP1 gene: 
    NM_002114.2  

    Unigene Cluster for HIVEP1:

    Human immunodeficiency virus type I enhancer binding protein 1
    Hs.567284  [show with all ESTs]
    Unigene Representative Sequence: X51435
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491710 ENST00000487103 ENST00000379388(uc003nac.3 uc011diq.2)
    ENST00000442081 ENST00000478545 ENST00000484210 ENST00000399469 ENST00000541134

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIVEP1
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HIVEP1 (see all 33):
    hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-30d hsa-miR-374a hsa-miR-218 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidHIVEP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIVEP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIVEP1
    Clone
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    OriGene clones in human, mouse for HIVEP1 (see all 5)
    OriGene ORF clones in mouse, rat for HIVEP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIVEP1 (NM_002114)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIVEP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIVEP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HIVEP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIVEP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIVEP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP1

    Additional mRNA sequence: 

    AK294338.1 AY673640.1 BC028111.2 BC140816.1 J05011.1 M32019.1 X51435.1 

    10 DOTS entries:

    DT.415700  DT.95244666  DT.415701  DT.415703  DT.91686138  DT.92421721  DT.121318317  DT.121318333 
    DT.40127623  DT.40131009 

    24/91 AceView cDNA sequences (see all 91):

    CF143584 N23133 AA563642 AW389765 BX097330 AW291295 M32019 BU742602 
    AI017317 AA399387 CF143585 BP350310 BM699466 AW389740 AA398086 AI611687 
    BG679671 CA430819 AI971788 AI033710 CF143583 AW628406 AW118764 BP345028 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIVEP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTATAGAC
    HIVEP1 Expression
    About this image


    See HIVEP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIVEP1

    SOURCE GeneReport for Unigene cluster: Hs.567284
        SABiosciences Custom PCR Arrays for HIVEP1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HIVEP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIVEP1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIVEP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIVEP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HIVEP1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hivep11 , 5 human immunodeficiency virus type I enhancer binding more1, 5 76.74(n)1
    72.26(a)1
      13 (20.72 cM)5
    1105211  NM_007772.21  NP_031798.21 
     420520215 
    chicken
    (Gallus gallus)
    Aves HIVEP11 human immunodeficiency virus type I enhancer binding more 66.29(n)
    60.9(a)
      420856  XM_418944.3  XP_418944.2 
    lizard
    (Anolis carolinensis)
    Reptilia HIVEP16
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343209.1(3359925-3403974)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.74012 Transcribed sequence with weak similarity to protein more 76.31(n)    AL896199.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hivep11 human immunodeficiency virus type I enhancer binding more 54.56(n)
    47.94(a)
      100000517  XM_001340663.3  XP_001340699.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta shn3 wing morphogenesis transcription factor 38(a)     --


    ENSEMBL Gene Tree for HIVEP1 (if available)
    TreeFam Gene Tree for HIVEP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIVEP1 gene
    HIVEP22  ZNF8312  HIVEP32  
    10 SIMAP similar genes for HIVEP1 using alignment to 9 protein entries:     ZEP1_HUMAN (see all proteins):
    kr-znf3    KBP-1    ZNF844    DKFZp434J0650    ZNF    HZF16
    DKFZp686N0199    PLZF    ZNF78L1    ZNFN1A2

    HIVEP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3280 SNPs in HIVEP1 are shown (see all 3280)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs802607881,2
    F--12010736(+) GGGAAC/AAAAAC 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs28762541,2
    H--12010816(+) AAGGGG/AAAACC 1 -- us2k1 trp34Minor allele frequency- A:0.00NS EA 418
    rs7494461,2
    C,F,A,H--12010820(+) GGAAAA/CCAGTT 1 -- us2k112Minor allele frequency- C:0.49EA NS NA WA CSA 547
    rs788257051,2
    C,F--12010839(+) TCAGGG/AATTTT 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1137044811,2
    C--12010841(+) AGGGAT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1154164261,2
    C,F--12010853(+) TTTTTT/GGCATC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs761662461,2
    F--12010927(+) CTTGAG/TGTGGA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs69181911,2
    C,H--12011217(+) TGTCAG/TGCTGG 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 420
    rs1381454431,2
    --12011253(+) GCTTCC/GGCACT 1 -- us2k10--------
    rs759066321,2
    F--12011257(+) CGGCAC/ATGGGA 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for HIVEP1 (12008995 - 12165232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HIVEP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656995CNV Deletion23128226
    esv2677354CNV Deletion23128226
    esv2662717CNV Deletion23128226
    esv2670070CNV Deletion23128226
    esv273428CNV Insertion20981092
    esv268157CNV Insertion20981092
    nsv509116CNV Insertion20534489
    nsv830586CNV Gain17160897
    esv22880CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194540    OMIM disorders: --

    8 diseases for HIVEP1:    About MalaCards
    esophageal varix    north american indian childhood cirrhosis    thrombosis    macular degeneration
    ataxia    esophagitis    alcoholism    neuronitis


    HIVEP1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HIVEP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 37.6 2 1727488 (1), 1694016 (1)

    Genetic Association Database (GAD): HIVEP1
    Human Genome Epidemiology (HuGE) Navigator: HIVEP1 (3 documents)

    Export disorders for HIVEP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIVEP1 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with HIVEP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. (PubMed id 8289330)1, 2, 9 Seeler J.S.... Gaynor R.B. (1994)
    2. Cirhin up-regulates a canonical NF-kappaB element thr ough strong interaction with Cirip/HIVEP1. (PubMed id 19732766)1, 2, 9 Yu B....Richter A. (2009)
    3. High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1. (PubMed id 1567844)1, 2, 9 Omichinski J.G....Gronenborn A.M. (1992)
    4. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. (PubMed id 1727488)1, 2, 9 Muchardt C.... Gaynor R.B. (1992)
    5. Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24. (PubMed id 2037300)1, 3, 9 Gaynor R.B....Lusis A.J. (1991)
    6. A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. (PubMed id 2108316)1, 2, 9 Baldwin A.S. Jr.... Sharp P.A. (1990)
    7. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)1, 4 Zuo L....Luo X. (2012)
    8. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    9. A follow-up study of a genome-wide association scan i dentifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. (PubMed id 20226436)1, 4 Morange P.E....Rosendaal F.R. (2010)
    10. A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. (PubMed id 2106471)1, 2 Fan C.M. and Maniatis T. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3096 HGNC: 4920 AceView: HIVEP1 Ensembl:ENSG00000095951 euGenes: HUgn3096
    ECgene: HIVEP1 H-InvDB: HIVEP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIVEP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIVEP1 gene:
    Search GeneIP for patents involving HIVEP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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