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Aliases for HIST4H4 Gene

Aliases for HIST4H4 Gene

  • Histone Cluster 4 H4 2 3 5
  • Histone 4, H4 2 3
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • Histone Cluster 4, H4 2
  • Histone H4 3
  • HIST2H4 4
  • H4FA 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4
  • H4/P 3

External Ids for HIST4H4 Gene

Previous GeneCards Identifiers for HIST4H4 Gene

  • GC12M015065
  • GC12M014822
  • GC12M014814
  • GC12M014692
  • GC12M014920

Summaries for HIST4H4 Gene

Entrez Gene Summary for HIST4H4 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST4H4 Gene

HIST4H4 (Histone Cluster 4 H4) is a Protein Coding gene. Diseases associated with HIST4H4 include Neuronal Ceroid Lipofuscinosis and Systemic Lupus Erythematosus. Among its related pathways are Mitotic Prophase and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST1H4H.

UniProtKB/Swiss-Prot for HIST4H4 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST4H4 Gene

Additional gene information for HIST4H4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST4H4 Gene

Genomics for HIST4H4 Gene

GeneHancer (GH) Regulatory Elements for HIST4H4 Gene

Promoters and enhancers for HIST4H4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I014768 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 700 4.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 GC12M014770 HIST4H4 LOC105369669 C12orf60 ENSG00000261324 H2AFJ ERP27
GH12I014255 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 43.5 +512.3 512303 7.2 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 MEF2D ENSG00000261324 ATF7IP HIST4H4 WBP11 RPL30P11 H2AFJ PLBD1 GC12P014255 GNAI2P1 GC12M014297
GH12I015710 Enhancer 1.3 Ensembl ENCODE dbSUPER 59.3 -941.3 -941315 3.3 FOXA2 ZFP64 YY1 ZNF213 KLF7 ZNF202 RXRA SP5 ZC3H11A MXD4 SUPT16HP1 ENSG00000261324 HIST4H4 WBP11 RNU6-251P EPS8 ENSG00000256564 GC12M015672 ENSG00000255565
GH12I014772 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 15.1 -3.6 -3628 3.8 PKNOX1 FOXA2 ARID4B SIN3A ZNF48 YY1 GLIS2 FOS RUNX3 ZNF202 H2AFJ PIR36886 GC12P014775 WBP11 C12orf60 ENSG00000261324 HIST4H4 ATF7IP ERP27
GH12I014945 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -184.2 -184183 19.1 HDGF PKNOX1 ATF1 FOXA2 SMAD1 YBX1 IRF4 YY1 ZNF766 GATA2 ARHGDIB ERP27 PDE6H WBP11 ART4 HIST4H4 H2AFJ SMCO3 C12orf60 ENSG00000256339
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST4H4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST4H4 gene promoter:

Genomic Locations for HIST4H4 Gene

Genomic Locations for HIST4H4 Gene
chr12:14,767,999-14,771,131
(GRCh38/hg38)
Size:
3,133 bases
Orientation:
Minus strand
chr12:14,920,933-14,924,065
(GRCh37/hg19)

Genomic View for HIST4H4 Gene

Genes around HIST4H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST4H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST4H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST4H4 Gene

Proteins for HIST4H4 Gene

  • Protein details for HIST4H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST4H4 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST4H4 Gene

neXtProt entry for HIST4H4 Gene

Post-translational modifications for HIST4H4 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and isoforms=80

Other Protein References for HIST4H4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST4H4 Gene

Domains & Families for HIST4H4 Gene

Gene Families for HIST4H4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST4H4 Gene

Suggested Antigen Peptide Sequences for HIST4H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST4H4: view

Function for HIST4H4 Gene

Molecular function for HIST4H4 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST4H4 Gene

Gene Ontology (GO) - Molecular Function for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IBA 3035717
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with HIST4H4: view
genes like me logo Genes that share phenotypes with HIST4H4: view

miRNA for HIST4H4 Gene

miRTarBase miRNAs that target HIST4H4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST4H4 Gene

Localization for HIST4H4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST4H4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region IDA,HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IBA,IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST4H4: view

Pathways & Interactions for HIST4H4 Gene

SuperPathways for HIST4H4 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST4H4: view

Interacting Proteins for HIST4H4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350767%0d%0a9606.ENSP00000336868%0d%0a9606.ENSP00000303408%0d%0a9606.ENSP00000349430%0d%0a9606.ENSP00000350580%0d%0a9606.ENSP00000358151%0d%0a
Selected Interacting proteins: ENSP00000350767 P62805-H4_HUMAN for HIST4H4 Gene via STRING MINT UniProtKB IID

Symbol External ID(s) Details
TP53BP1
KDM4A
BRD2
COPRS
PHF20

Gene Ontology (GO) - Biological Process for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST4H4: view

No data available for SIGNOR curated interactions for HIST4H4 Gene

Drugs & Compounds for HIST4H4 Gene

(28) Drugs for HIST4H4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(21) Additional Compounds for HIST4H4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HIST4H4: view

Transcripts for HIST4H4 Gene

mRNA/cDNA for HIST4H4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST4H4 Gene

Histone cluster 4, H4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST4H4 Gene

No ASD Table

Relevant External Links for HIST4H4 Gene

GeneLoc Exon Structure for
HIST4H4
ECgene alternative splicing isoforms for
HIST4H4

Expression for HIST4H4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST4H4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST4H4 Gene



Protein tissue co-expression partners for HIST4H4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST4H4 Gene:

HIST4H4

SOURCE GeneReport for Unigene cluster for HIST4H4 Gene:

Hs.745457

Evidence on tissue expression from TISSUES for HIST4H4 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Eye(4.2)
  • Blood(2.4)
  • Intestine(2.3)
  • Kidney(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with HIST4H4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST4H4 Gene

Orthologs for HIST4H4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST4H4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIST4H4 34
  • 100 (a)
OneToOne
LOC619094 33
  • 81.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HIST4H4 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIST4H4 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIST4H4 34
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680097 33
  • 84.14 (n)
mouse
(Mus musculus)
Mammalia Hist1h4i 33 16
  • 83.5 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734426 33
  • 81.23 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.17 34
  • 100 (a)
ManyToMany
LOC562770 33
  • 80.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012574 33
  • 80.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33903 33
  • 79.61 (n)
worm
(Caenorhabditis elegans)
Secernentea his-5 33
  • 78.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF2 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59690 33
  • 77.35 (n)
rice
(Oryza sativa)
Liliopsida Os05g0462700 33
  • 81.55 (n)
Species where no ortholog for HIST4H4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST4H4 Gene

ENSEMBL:
Gene Tree for HIST4H4 (if available)
TreeFam:
Gene Tree for HIST4H4 (if available)

Paralogs for HIST4H4 Gene

(3) SIMAP similar genes for HIST4H4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST4H4: view

Variants for HIST4H4 Gene

Sequence variations from dbSNP and Humsavar for HIST4H4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000511644 -- 14,771,126(-) C/T 5_prime_UTR_variant
rs1001056933 -- 14,770,321(-) C/G downstream_transcript_variant
rs1002467188 -- 14,770,580(-) T/C downstream_transcript_variant
rs1003052524 -- 14,772,524(-) C/T upstream_transcript_variant
rs1003348445 -- 14,771,235(-) A/G upstream_transcript_variant

Variation tolerance for HIST4H4 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST4H4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST4H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HIST4H4 Gene

Disorders for HIST4H4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HIST4H4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuronal ceroid lipofuscinosis
  • batten disease
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for HIST4H4

genes like me logo Genes that share disorders with HIST4H4: view

No data available for Genatlas for HIST4H4 Gene

Publications for HIST4H4 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  2. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PMID: 21724829) Kang B … Zhang Z (Genes & development 2011) 3 4 58
  3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q … Shipp MA (Molecular cell 2009) 3 4 58
  4. Analysis of interaction partners of H4 histone by a new proteomics approach. (PMID: 19862764) Saade E … Ogryzko V (Proteomics 2009) 3 22 58
  5. A new epigenetic marker: the replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail. (PMID: 19348949) Fidlerová H … Raska I (Journal of structural biology 2009) 3 22 58

Products for HIST4H4 Gene