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HIST4H4 Gene

protein-coding   GIFtS: 50
GCID: GC12M014920

Histone Cluster 4, H4

(Previous names: histone 4, H4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 4, H41 2     H4/O3
Histone 4, H41 2     H4F23
H4/p2     H4FA3
Histone H42     H4FB3
H4/A3     H4FC3
H4/B3     H4FD3
H4/C3     H4FE3
H4/D3     H4FG3
H4/E3     H4FH3
H4/G3     H4FI3
H4/H3     H4FJ3
H4/I3     H4FK3
H4/J3     H4FM3
H4/K3     H4FN3
H4/M3     H4FO3
H4/N3     HIST2H43

External Ids:    HGNC: 205101   Entrez Gene: 1215042   Ensembl: ENSG000001978377   OMIM: 6150695   UniProtKB: P628053   

Export aliases for HIST4H4 gene to outside databases

Previous GC identifers: GC12M015065 GC12M014822 GC12M014814 GC12M014692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST4H4 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene
lack polyA tails; instead, they contain a palindromic termination element. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST4H4 Gene:
HIST4H4 (histone cluster 4, H4) is a protein-coding gene. Diseases associated with HIST4H4 include fragile x syndrome, and neuronal ceroid lipofuscinosis. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST4H4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HIST4H4 gene promoter:
         SRF   GR   C/EBPbeta   SRF (504 AA)   IRF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST4H4 promoter sequence
   Search Chromatin IP Primers for HIST4H4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST4H4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

HIST4H4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST4H4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014920:  view genomic region     (about GC identifiers)

Start:
14,920,933 bp from pter      End:
14,924,065 bp from pter
Size:
3,133 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
Selected PDB 3D structures from and Proteopedia for HIST4H4 (see all 55):
2BQZ (3D)        2CV5 (3D)        2KWN (3D)        2KWO (3D)        2LVM (3D)        2QQS (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST4H4: NX_P62805

Explore proteomics data for HIST4H4 at MOPED

Post-translational modifications: 

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus (H4H4)

  • See HIST4H4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_778224.1  
    ENSEMBL proteins: 
     ENSP00000350767   ENSP00000443017  
    Reactome Protein details: P62805

    HIST4H4 Human Recombinant Protein Products:

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    Search LSBio for Antibodies for HIST4H4

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    EMD Millipore Kits and Assays for the Analysis of HIST4H4
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST4H4
    Cloud-Clone Corp. CLIAs for HIST4H4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST4H4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST4H4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST4H4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST4H4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST4H4

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST4H4:
    hsa-mir-34a-5p (MIRT025525), hsa-mir-615-3p (MIRT040245), hsa-mir-26a-5p (MIRT050170)

    Block miRNA regulation of human, mouse, rat HIST4H4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HIST4H4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HIST4H4 (NM_175054)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST4H4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST4H4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST4H4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H4_HUMAN, P62805: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    extracellular4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST4H4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST4H4 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HIST4H4
        Notch Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST4H4
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST4H4
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST4H4
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    Selected Reactome Pathways for HIST4H4 (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST4H4):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST4H4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST4H4
    Interactions:

        GeneGlobe Interaction Network for HIST4H4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST4H4 (P628051, 2, 3 ENSP000003507674) via UniProtKB, MINT, STRING, and/or I2D (see all 704)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD2P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000215077P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234507P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234704P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000235307P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-templated transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST4H4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST4H4 (H4)

    Selected Novoseek inferred chemical compound relationships for HIST4H4 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scriptaid 76.8 2 16391833 (1), 14620913 (1)
    apicidin 75.9 3 14985106 (1), 17258775 (1), 17203205 (1)
    depsipeptide 71.9 4 17286952 (1), 17610380 (1), 12592335 (1), 15024582 (1)
    lysine 66.7 21 18418072 (1), 19801601 (1), 9820584 (1), 12724220 (1) (see all 18)
    butyrate 64.7 19 7646441 (4), 9214697 (1), 15261456 (1), 10716680 (1) (see all 13)
    phenylbutyrate 61.1 2 14871995 (1), 19723072 (1)
    suberoylanilide hydroxamic acid 56.1 1 16928817 (1)
    5-aza-2'deoxycytidine 55.2 2 10319871 (1)
    nabu 46.3 3 15812237 (1), 9826026 (1)
    valproic acid 43.3 7 18847317 (1), 17534580 (1), 15735039 (1), 17522015 (1)



    HIST4H4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST4H4 gene: 
    NM_175054.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358064(uc001rce.3) ENST00000537096 ENST00000541592 ENST00000537853
    ENST00000540565 ENST00000539745(uc001rcf.4)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HIST4H4
      QuantiFast Probe-based Assays in human, mouse, rat HIST4H4

    18 AceView cDNA sequences:

    BI063334 NM_175054 BF746651 BC020884 BG436099 AA318102 AV729148 BQ423204 
    CB961253 BX505653 CB959866 BQ953651 BM907072 AV764584 C17554 BQ062528 
    CB963564 BQ229008 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST4H4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST4H4 Expression
    About this image

    HIST4H4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST4H4 Protein Expression
        Custom PCR Arrays for HIST4H4
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    QuantiFast Probe-based Assays in human, mouse, rat HIST4H4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST4H4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST4H4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist4h45
    Hist1h4i1
    histone cluster 4, H45
    histone cluster 1, H4i1
    83.5(n)1
    100(a)1
      6 (66.72 cM)5
    3191581  NM_175656.21  NP_783587.11 
     1368015535 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017344261 histone H4-like 81.23(n)
    100(a)
      101734426  XM_004917000.1  XP_004917057.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5627701 histone H4-like 80.91(n)
    100(a)
      562770  XM_005172395.1  XP_005172452.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG339031 His4:CG33903 79.61(n)
    99.03(a)
      3772254  NM_001032126.1  NP_001027297.1 
    worm
    (Caenorhabditis elegans)
    Secernentea his-51 his-5 78.32(n)
    99.03(a)
      179233  NM_072799.3  NP_505200.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G596901 AT5G59690 77.35(n)
    98.06(a)
      836090  NM_125361.2  NP_568911.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g04627001 Os05g0462700 81.55(n)
    98.06(a)
      4339029  NM_001062304.1  NP_001055769.1 


    ENSEMBL Gene Tree for HIST4H4 (if available)
    TreeFam Gene Tree for HIST4H4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST4H4 gene
    HIST1H4E2  HIST1H4K2  HIST2H4A2  HIST1H4F2  HIST1H4L2  HIST2H4B2  HIST1H4I2  HIST1H4B2  
    HIST1H4A2  HIST1H4H2  HIST1H4C2  HIST1H4D2  HIST1H4J2  HIST1H4G2  
    3 SIMAP similar genes for HIST4H4 using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    HIST4H4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for HIST4H4 (see all 56)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157688581,2
    C,F--14923164(+) CTAGAG/ACTGCA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs743491871,2
    C,F--14923180(+) CTTTCG/CGGCTT 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1488702591,2
    --14923189(+) TTGCAA/GGTAGC 1 -- ds50010--------
    rs1387658031,2
    C--14923265(+) GCGTG-/CACGCT 1 -- ds50010--------
    rs740681191,2
    C,F--14923295(+) GAAGTC/AACCTA 1 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs1858178211,2
    --14923320(+) TGGAAA/GCCATC 1 -- ds50010--------
    rs1480575011,2
    C--14923332(+) GATACA/GTGCTT 1 -- ds50010--------
    rs169102461,2
    C,F--14923347(+) GCCAAC/AGACTC 1 -- ds50014Minor allele frequency- A:0.02NA EA 262
    rs1876742761,2
    --14923437(+) TTTTGA/GGAGGT 1 -- ds50010--------
    rs1113192291,2
    C--14923507(+) TTGAGG/ATCTAG 1 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for HIST4H4 (14920933 - 14924065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST4H4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898817CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST4H4
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST4H4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615069    OMIM disorders: --

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell
    NHL). Translocation t(3;6)(q27;p21), with BCL6

  • Selected diseases for HIST4H4 (see all 41):    
    About MalaCards
    fragile x syndrome    neuronal ceroid lipofuscinosis    cutaneous t cell lymphoma    retinoblastoma
    esophageal squamous cell carcinoma    choriocarcinoma    medulloblastoma    hepatocellular carcinoma
    ovarian cancer    non-hodgkin lymphoma    hodgkin's lymphoma    chronic myeloid leukemia
    colorectal cancer    b-cell lymphomas    cervical cancer    hepatitis c virus
    squamous cell carcinoma    breast and colorectal cancer    systemic lupus erythematosus    esophagitis

    1 disease from the University of Copenhagen DISEASES database for HIST4H4:
    Cancer

    HIST4H4 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HIST4H4 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 32.1 13 15765097 (4), 19961487 (2), 16699174 (1), 12579268 (1) (see all 7)
    retinoblastoma 27.4 1 17610380 (1)
    tumors 27.3 15 16863736 (2), 12724227 (1), 16001982 (1), 19086847 (1) (see all 14)
    lung carcinoma 22.3 5 19596041 (1), 19376846 (1), 18974389 (1)
    colon cancer 18.5 1 12975486 (1)
    leukemia 10.3 4 16409301 (1), 19578722 (1), 2133550 (1), 18295477 (1)
    breast cancer 8.97 8 16861913 (2), 11682064 (2), 16322686 (1), 16707467 (1)
    myeloid leukemia chronic 8.5 2 19962902 (1), 18413791 (1)
    gastric carcinoma 7.61 5 12385581 (3), 15586362 (1)
    metastasis 5.24 1 12385581 (1)


    Export disorders for HIST4H4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST4H4 gene, integrated from 10 sources (see all 442):
    (articles sorted by number of sources associating them with HIST4H4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)1, 2 Kang B....Zhang Z. (Genes Dev. 2011)
    3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)1, 2 Yan Q....Shipp M.A. (Mol. Cell 2009)
    4. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2 Braastad C.D....Stein G.S. (Gene 2004)
    5. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2 Wang Y.... Coonrod S.A. (Science 2004)
    6. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (Science 1987)
    8. Acetylated histone H4 is reduced in human gastric adenomas and carcinomas. (PubMed id 12385581)1, 9 Ono S....Yasui W. (amp 2002)
    9. Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. (PubMed id 15095300)1, 9 Toh Y....Nicolson G.L. (Int. J. Cancer 2004)
    10. Histone H4 is a major component of the antimicrobial action of human sebocytes. (PubMed id 19536143)1, 9 Lee D.Y....Gallo R.L. (J. Invest. Dermatol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121504 HGNC: 20510 AceView: HIST4H4 Ensembl:ENSG00000197837 euGenes: HUgn121504
    ECgene: HIST4H4 Kegg: 121504 H-InvDB: HIST4H4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST4H4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST4H4 gene:
    Search GeneIP for patents involving HIST4H4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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