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Aliases for HIST4H4 Gene

Aliases for HIST4H4 Gene

  • Histone Cluster 4, H4 2 3
  • Histone 4, H4 2 3
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • HIST2H4 4
  • H4/G 4
  • H4FG 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4
  • H4/P 3

External Ids for HIST4H4 Gene

Previous GeneCards Identifiers for HIST4H4 Gene

  • GC12M015065
  • GC12M014822
  • GC12M014814
  • GC12M014692
  • GC12M014920

Summaries for HIST4H4 Gene

Entrez Gene Summary for HIST4H4 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST4H4 Gene

HIST4H4 (Histone Cluster 4, H4) is a Protein Coding gene. Diseases associated with HIST4H4 include fragile x syndrome. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4C.

UniProtKB/Swiss-Prot for HIST4H4 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST4H4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST4H4 Gene

Genomics for HIST4H4 Gene

Regulatory Elements for HIST4H4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST4H4 Gene

Chromosome:
12
Start:
14,767,999 bp from pter
End:
14,771,131 bp from pter
Size:
3,133 bases
Orientation:
Minus strand

Genomic View for HIST4H4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HIST4H4 Gene

Proteins for HIST4H4 Gene

  • Protein details for HIST4H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST4H4 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST4H4 Gene

neXtProt entry for HIST4H4 Gene

Proteomics data for HIST4H4 Gene at MOPED

Post-translational modifications for HIST4H4 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at Lys 32, Lys 60, Lys 78, and Lys 80
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST4H4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for HIST4H4

No data available for DME Specific Peptides for HIST4H4 Gene

Domains & Families for HIST4H4 Gene

Gene Families for HIST4H4 Gene

HGNC:

Protein Domains for HIST4H4 Gene

Suggested Antigen Peptide Sequences for HIST4H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST4H4: view

Function for HIST4H4 Gene

Molecular function for HIST4H4 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 3035717
GO:0005515 protein binding IPI 9540062
GO:0035575 histone demethylase activity (H4-K20 specific) TAS --
GO:0042393 histone binding IPI 20498094
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST4H4: view

Phenotypes for HIST4H4 Gene

genes like me logo Genes that share phenotypes with HIST4H4: view

miRNA for HIST4H4 Gene

miRTarBase miRNAs that target HIST4H4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST4H4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST4H4 Gene

Localization for HIST4H4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST4H4 Gene COMPARTMENTS Subcellular localization image for HIST4H4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 14585971
genes like me logo Genes that share ontologies with HIST4H4: view

Pathways & Interactions for HIST4H4 Gene

SuperPathways for HIST4H4 Gene

Superpath Contained pathways
1 RNA Polymerase I Promoter Opening
2 RNA Polymerase I Transcription
3 G2/M DNA damage checkpoint
4 DNA Double-Strand Break Repair
5 Cellular Senescence
genes like me logo Genes that share pathways with HIST4H4: view

Gene Ontology (GO) - Biological Process for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000723 telomere maintenance TAS --
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006281 DNA repair TAS --
genes like me logo Genes that share ontologies with HIST4H4: view

No data available for SIGNOR curated interactions for HIST4H4 Gene

Drugs & Compounds for HIST4H4 Gene

(25) Drugs for HIST4H4 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved Pharma 6
Dexamethasone Approved, Investigational Pharma Agonist 1806
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Trastuzumab Approved, Investigational Pharma HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 688

(24) Additional Compounds for HIST4H4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Aza-2deoxycytidine
adenylate
butyrate
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
  • 4-Amino-2-hydroxypyrimidine
  • 4-Amino-2-oxo-1,2-dihydropyrimidine
  • 4-Aminouracil
  • Cytosine
71-30-7
depsipeptide
genes like me logo Genes that share compounds with HIST4H4: view

Transcripts for HIST4H4 Gene

mRNA/cDNA for HIST4H4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST4H4 Gene

Histone cluster 4, H4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST4H4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST4H4 Gene

No ASD Table

Relevant External Links for HIST4H4 Gene

GeneLoc Exon Structure for
HIST4H4
ECgene alternative splicing isoforms for
HIST4H4

Expression for HIST4H4 Gene

mRNA expression in normal human tissues for HIST4H4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST4H4 Gene



SOURCE GeneReport for Unigene cluster for HIST4H4 Gene Hs.745457

genes like me logo Genes that share expression patterns with HIST4H4: view

Protein tissue co-expression partners for HIST4H4 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST4H4 Gene

Orthologs for HIST4H4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST4H4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC619094 35
  • 81.23 (n)
  • 99.03 (a)
HIST4H4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist1h4i 35
  • 83.5 (n)
  • 100 (a)
Hist4h4 16
rat
(Rattus norvegicus)
Mammalia LOC680097 35
  • 84.14 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia HIST4H4 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIST4H4 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIST4H4 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734426 35
  • 81.23 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562770 35
  • 80.91 (n)
  • 100 (a)
si:ch211-113a14.17 36
  • 100 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012574 35
  • 80.91 (n)
  • 99.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33903 35
  • 79.61 (n)
  • 99.03 (a)
worm
(Caenorhabditis elegans)
Secernentea his-5 35
  • 78.32 (n)
  • 99.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59690 35
  • 77.35 (n)
  • 98.06 (a)
rice
(Oryza sativa)
Liliopsida Os05g0462700 35
  • 81.55 (n)
  • 98.06 (a)
Species with no ortholog for HIST4H4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST4H4 Gene

ENSEMBL:
Gene Tree for HIST4H4 (if available)
TreeFam:
Gene Tree for HIST4H4 (if available)

Paralogs for HIST4H4 Gene

Paralogs for HIST4H4 Gene

(3) SIMAP similar genes for HIST4H4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST4H4: view

Variants for HIST4H4 Gene

Structural Variations from Database of Genomic Variants (DGV) for HIST4H4 Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294

Variation tolerance for HIST4H4 Gene

Residual Variation Intolerance Score: 32.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST4H4 Gene

HapMap Linkage Disequilibrium report
HIST4H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HIST4H4 Gene

Disorders for HIST4H4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HIST4H4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fragile x syndrome
  • mental retardation, x-linked, fraxe type
- elite association

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

Relevant External Links for HIST4H4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST4H4
genes like me logo Genes that share disorders with HIST4H4: view

No data available for Genatlas for HIST4H4 Gene

Publications for HIST4H4 Gene

  1. K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts. (PMID: 19369050) Wijeratne S.S. … Zempleni J. (J. Nutr. Biochem. 2010) 23 67
  2. Chemical phosphorylation of histidine-containing peptides based on the sequence of histone H4 and their dephosphorylation by protein histidine phosphatase. (PMID: 19836471) Attwood P.V. … Klumpp S. (Biochim. Biophys. Acta 2010) 23 67
  3. Suppressive effect on MDC and IP-10 expression in monocytes by endocrine disruptor chemicals. (PMID: 19756997) Yeh C.H. … Hung C.H. (Inflammation 2010) 23 67
  4. Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain. (PMID: 20048151) Umehara T. … Yokoyama S. (J. Biol. Chem. 2010) 23 67
  5. A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription. (PMID: 20139424) Du H.N. … Briggs S.D. (J. Biol. Chem. 2010) 23 67

Products for HIST4H4 Gene

  • Cloud-Clone Corp. Antibodies for HIST4H4
  • Cloud-Clone Corp. Proteins for HIST4H4
  • Cloud-Clone Corp Assay Kits for HIST4H4

Sources for HIST4H4 Gene

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