HIST4H4 Gene
protein-coding GIFtS: 54
GCID: GC12M014920
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|
histone cluster 4, H4(Previous names: histone 4, H4 )
| |
Aliases
for HIST4H4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Histone Cluster 4, H41 2 | | H4/O3 | | Histone 4, H41 2 | | H4F23 | | MGC241161 | | H4FA3 | | H4/P1 | | H4FB3 | | Histone H42 | | H4FC3 | | H4/A3 | | H4FD3 | | H4/B3 | | H4FE3 | | H4/C3 | | H4FG3 | | H4/D3 | | H4FH3 | | H4/E3 | | H4FI3 | | H4/G3 | | H4FJ3 | | H4/H3 | | H4FK3 | | H4/I3 | | H4FM3 | | H4/J3 | | H4FN3 | | H4/K3 | | H4FO3 | | H4/M3 | | HIST2H43 | | H4/N3 | | |
Export aliases for HIST4H4 gene to outside databasesPrevious GC identifers: GC12M015065 GC12M014822 GC12M014814 GC12M014692 |
Summaries
for HIST4H4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIST4H4:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs ofeach of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through theinteraction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails;instead, they contain a palindromic termination element. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: H4_HUMAN, P62805Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling
Gene Wiki entry for HIST4H4
|
Genomic Views
for HIST4H4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIST4H4 gene promoter:
SRF GR C/EBPbeta SRF (504 AA) IRF-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIST4H4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST4H4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p12.3 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p12.3HIST4H4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M014920: view genomic region
(about GC identifiers)
Start:
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14,920,933 bp from pter |
End:
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14,924,065 bp from pter |
Size:
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3,133 bases |
Orientation:
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minus strand |
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Proteins
for HIST4H4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See
protein sequence)Recommended Name: Histone H4 Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from  and Proteopedia  for HIST4H4 (see all 46):2BQZ (3D)
2CV5 (3D)
2LVM (3D)
2RNY (3D)
2RS9 (3D)
3A6N (3D)
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7Explore the universe of human proteins at neXtProt for HIST4H4: NX_P62805
Post-translational modifications:
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of thegenome but not in heterochromatin1
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylationat Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4(H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed bySET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histonechaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H41
Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interactionbetween histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histoneH4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it mayfunction as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21methylation (H4K20me)1
Sumoylated, which is associated with transcriptional repression1
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks activepromoters and enhancers and confers resistance to transcriptional repressors. It is also associated withpost-meiotically activated genes on autosomes1
View modification sites using PhosphoSitePlus2 (H4H4)View neXtProt modification sites for NX_P62805
HIST4H4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778224.1
ENSEMBL proteins: ENSP00000350767 ENSP00000443017 Reactome Protein details: P62805
Human Recombinant Protein Products for HIST4H4:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
HIST4H4 for ontologies About GeneDecksing
HIST4H4 Antibody Products:
Assay Products for HIST4H4: |
Protein
Domains /
Families
for HIST4H4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIST4H4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62805ProtoNet protein and cluster: P62805 UniProtKB/Swiss-Prot: H4_HUMAN, P62805Similarity: Belongs to the histone H4 family |
Function
for HIST4H4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
HIST4H4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST4H4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST4H4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HIST4H4 (NM_175054) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIST4H4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST4H4 |
|
Pathways & Interactions
for HIST4H4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signal transduction Activin A signaling regulation | | | 2 | Transcription_Sin3 and NuRD in transcription regulation | | | 3 | Development_Notch Signaling Pathway | | | 4 | Development NOTCH1-mediated pathway for NF-KB activity modulation | | | 5 | Type II interferon signaling (IFNG) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for HIST4H4
4  GeneGo (Thomson Reuters) Pathways for HIST4H4
2  BioSystems Pathways for HIST4H4
5/17 
Reactome Pathways for HIST4H4 (see all 17)
1 
Kegg Pathway (Kegg details for HIST4H4):
HIST4H4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST4H4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/608 Interacting proteins for HIST4H4 (P628051, 2, 3 ENSP000003507674) via UniProtKB, MINT, STRING, and/or I2D (see all 608)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000723 | telomere maintenance |
-- | -- | | GO:0006325 | chromatin organization |
-- | -- | | GO:0006334 | nucleosome assembly |
-- | -- | | GO:0034080 | CENP-A containing nucleosome assembly at centromere |
-- | -- | | GO:0045653 | negative regulation of megakaryocyte differentiation |
-- | -- |
HIST4H4 for ontologies About GeneDecksing
|
Drugs & Compounds
for HIST4H4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HIST4H4 for compounds About GeneDecksing
 Browse Tocris compounds for HIST4H4
10/49 Novoseek chemical compound relationships for HIST4H4 gene (see all 49) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| scriptaid |
76.8 |
2 |
16391833 (1), 14620913 (1) |
| apicidin |
75.9 |
3 |
14985106 (1), 17258775 (1), 17203205 (1) |
| depsipeptide |
71.9 |
4 |
17286952 (1), 17610380 (1), 12592335 (1), 15024582 (1) |
| lysine |
66.7 |
21 |
18418072 (1), 19801601 (1), 9820584 (1), 12724220 (1) (see all 18) |
| butyrate |
64.7 |
19 |
7646441 (4), 9214697 (1), 15261456 (1), 10716680 (1) (see all 13) |
| phenylbutyrate |
61.1 |
2 |
14871995 (1), 19723072 (1) |
| suberoylanilide hydroxamic acid |
56.1 |
1 |
16928817 (1) |
| 5-aza-2'deoxycytidine |
55.2 |
2 |
10319871 (1) |
| nabu |
46.3 |
3 |
15812237 (1), 9826026 (1) |
| valproic acid |
43.3 |
7 |
18847317 (1), 17534580 (1), 15735039 (1), 17522015 (1) |
Search CenterWatch for drugs/clinical trials and news about HIST4H4 / H4
|
Transcripts
for HIST4H4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIST4H4 gene: NM_175054.2 Unigene Cluster for HIST4H4: Histone cluster 4, H4 Hs.718935 [show with all ESTs]Unigene Representative Sequence: BM9070726 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358064(uc001rce.3) ENST00000537096 ENST00000541592 ENST00000537853
ENST00000540565 ENST00000539745(uc001rcf.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST4H4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST4H4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HIST4H4 (NM_175054) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIST4H4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST4H4 |
Additional cDNA sequence: AK311916.1 2 DOTS entries: DT.91698592 DT.100745482 18 AceView cDNA sequences: NM_175054 BI063334 BF746651 BQ423204 CB959866 CB961253 BC020884 AV729148 BM907072 BX505653 BQ953651 BG436099 AA318102 BQ062528 AV764584 C17554 CB963564 BQ229008
GeneLoc Exon Structure
|
Expression
for HIST4H4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIST4H4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HIST4H4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.718935
SABiosciences Custom PCR Arrays for HIST4H4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST4H4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HIST4H4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST4H4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST4H4 |
Orthologs
for HIST4H4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for HIST4H4 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for HIST4H4 (if available)
TreeFam Gene Tree for HIST4H4 (if available) |
Paralogs
for HIST4H4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIST4H4 gene
- HIST1H4A1 2 HIST1H4I1 2 HIST1H4K1 2 HIST1H4E1 2 HIST1H4J1 2 HIST1H4D1 2 HIST1H4B1 2 HIST1H4L1 2
- HIST1H4H1 2 HIST2H4A1 2 HIST1H4C1 2 HIST2H4B1 2 HIST1H4F1 2 HIST1H4G2
3 SIMAP similar genes for HIST4H4 using alignment to 1 protein entry: H4_HUMAN:HIST1H4J HIST1H4H HIST1H4G
HIST4H4 for paralogs About GeneDecksing
|
Genomic Variants
for HIST4H4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIST4H4 (14920933 - 14924065 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HIST4H4
1 CNV: 86230 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST4H4 |
|
Disorders
/ Diseases
for HIST4H4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIST4H4 for disorders About GeneDecksing
OMIM gene information: 615069
OMIM disorders: --
20/41  diseases for HIST4H4 (see all 41): About MalaCardsceroid lipofuscinosis neuronal ceroid-lipofuscinosis dna topoisomerase ii non-hodgkin lymphoma
fragile x syndrome x inactivation b-cell lymphomas esophageal squamous cell carcinoma
systemic lupus erythematosus squamous cell carcinoma lupus erythematosus hodgkin's lymphoma
cutaneous t cell lymphoma hepatocellular carcinoma carcinoma colon cancer
hepatitis c ovarian cancer skin cancer breast cancer
1 disease from the University of Copenhagen DISEASES database for HIST4H4:Cancer 10/22 Novoseek disease relationships for HIST4H4 gene (see all 22) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
32.1 |
13 |
15765097 (4), 19961487 (2), 16699174 (1), 12579268 (1) (see all 7) |
| retinoblastoma |
27.4 |
1 |
17610380 (1) |
| tumors |
27.3 |
15 |
16863736 (2), 12724227 (1), 16001982 (1), 19086847 (1) (see all 14) |
| lung carcinoma |
22.3 |
5 |
19596041 (1), 19376846 (1), 18974389 (1) |
| colon cancer |
18.5 |
1 |
12975486 (1) |
| leukemia |
10.3 |
4 |
16409301 (1), 19578722 (1), 2133550 (1), 18295477 (1) |
| breast cancer |
8.97 |
8 |
16861913 (2), 11682064 (2), 16322686 (1), 16707467 (1) |
| myeloid leukemia chronic |
8.5 |
2 |
19962902 (1), 18413791 (1) |
| gastric carcinoma |
7.61 |
5 |
12385581 (3), 15586362 (1) |
| metastasis |
5.24 |
1 |
12385581 (1) |
Export disorders for HIST4H4 gene to outside databases
|
Publications
for HIST4H4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIST4H4 gene, integrated from 9 sources (see all 428):
(articles sorted by number of sources associating them with HIST4H4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
- Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)1, 2 Kang B....Zhang Z. (2011)
- BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)1, 2 Yan Q....Shipp M.A. (2009)
- Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2 Braastad C.D....Stein G.S. (2004)
- Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2 Wang Y.... Coonrod S.A. (2004)
- Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (2003)
- Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (1987)
- Acetylated histone H4 is reduced in human gastric adenomas and carcinomas. (PubMed id 12385581)1, 9 Ono S....Yasui W. (2002)
- Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. (PubMed id 15095300)1, 9 Toh Y....Nicolson G.L. (2004)
- Histone H4 is a major component of the antimicrobial action of human sebocytes. (PubMed id 19536143)1, 9 Lee D.Y....Gallo R.L. (2009)
|
External Searches for HIST4H4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIST4H4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIST4H4 gene
(According to HUGE)
About This Section
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Specialized Databases showing HIST4H4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HIST4H4 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for HIST4H4 gene:
Search GeneIP for patents involving HIST4H4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HIST4H4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for HIST4H4 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST4H4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST4H4 | | | OriGene Protein Over-expression Lysate for HIST4H4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIST4H4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST4H4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST4H4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HIST4H4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIST4H4 | | OriGene Custom Protein Services for HIST4H4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST4H4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST4H4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST4H4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST4H4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST4H4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST4H4 |
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| | | | Search Tocris compounds for HIST4H4 |
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 | | | HIST4H4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for HIST4H4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST4H4 |
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