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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST4H4 Gene

protein-coding   GIFtS: 53
GCID: GC12M014920

Histone Cluster 4, H4

(Previous names: histone 4, H4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 4, H41 2     H4/O3
Histone 4, H41 2     H4F23
H4/p2     H4FA3
Histone H42     H4FB3
H4/A3     H4FC3
H4/B3     H4FD3
H4/C3     H4FE3
H4/D3     H4FG3
H4/E3     H4FH3
H4/G3     H4FI3
H4/H3     H4FJ3
H4/I3     H4FK3
H4/J3     H4FM3
H4/K3     H4FN3
H4/M3     H4FO3
H4/N3     HIST2H43

External Ids:    HGNC: 205101   Entrez Gene: 1215042   Ensembl: ENSG000001978377   OMIM: 6150695   UniProtKB: P628053   

Export aliases for HIST4H4 gene to outside databases

Previous GC identifers: GC12M015065 GC12M014822 GC12M014814 GC12M014692


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST4H4 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene
lack polyA tails; instead, they contain a palindromic termination element. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST4H4 Gene: 
HIST4H4 (histone cluster 4, H4) is a protein-coding gene. Diseases associated with HIST4H4 include neuronal ceroid lipofuscinosis, and fragile x syndrome, and among its related super-pathways are Signal transduction Activin A signaling regulation and Development NOTCH1-mediated pathway for NF-KB activity modulation. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST4H4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST4H4 gene promoter:
         SRF   GR   C/EBPbeta   SRF (504 AA)   IRF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST4H4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST4H4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST4H4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

HIST4H4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST4H4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014920:  view genomic region     (about GC identifiers)

Start:
14,920,933 bp from pter      End:
14,924,065 bp from pter
Size:
3,133 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST4H4 (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST4H4: NX_P62805

Explore proteomics data for HIST4H4 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin
  • UniProtKB: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation
  • UniProtKB: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage
  • UniProtKB: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • UniProtKB: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H4
  • UniProtKB: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)
  • UniProtKB: Sumoylated, which is associated with transcriptional repression
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus (H4H4)
  • View neXtProt modification sites for NX_P62805

  • HIST4H4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST4H4 Protein Expression
    REFSEQ proteins: NP_778224.1  
    ENSEMBL proteins: 
     ENSP00000350767   ENSP00000443017  
    Reactome Protein details: P62805
    Human Recombinant Protein Products for HIST4H4: 
    EMD Millipore Purified and/or Recombinant HIST4H4 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    GenScript Custom Purified and Recombinant Proteins Services for HIST4H4
    Novus Biologicals HIST4H4 Proteins
    Novus Biologicals HIST4H4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST4H4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST4H4 for ontologies           About GeneDecksing



    HIST4H4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST4H4
    R&D Systems Antibodies for HIST4H4 (Histone H4)
    OriGene Antibodies for HIST4H4
    OriGene Custom Antibody Services for HIST4H4
    GenScript Custom Superior Antibodies Services for HIST4H4
    Novus Biologicals HIST4H4 Antibodies
    Abcam antibodies for HIST4H4
    Cloud-Clone Corp. Antibodies for HIST4H4 
    ThermoFisher Antibodies for HIST4H4
    Search LSBio for Antibodies for HIST4H4 

    Assay Products for HIST4H4: 
    EMD Millipore Kits and Assays for the Analysis of HIST4H4
    OriGene Custom Assay Services for HIST4H4
    R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for HIST4H4 (Histone H4)
    GenScript Custom Assay Services for HIST4H4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST4H4 
    Cloud-Clone Corp. CLIAs for HIST4H4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST4H4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST4H4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST4H4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST4H4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST4H4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST4H4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST4H4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HIST4H4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIST4H4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST4H4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST4H4
    Sirion Biotech Customized adenovirus for overexpression of HIST4H4

    Clone
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    OriGene clones in human, mouse for HIST4H4 (see all 6)
    OriGene ORF clones in mouse, rat for HIST4H4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST4H4 (NM_175054)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST4H4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST4H4
    Sirion Biotech Customized lentivirus for stable overexpression of HIST4H4 
                         Customized lentivirus expression plasmids for stable overexpression of HIST4H4 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST4H4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST4H4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    3Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    4Viral carcinogenesis
    Viral carcinogenesis
    5Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for HIST4H4
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    1 R&D Systems Pathway for HIST4H4
        Notch Signaling Pathways


    4 GeneGo (Thomson Reuters) Pathways for HIST4H4
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST4H4
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    5/11        Reactome Pathways for HIST4H4 (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST4H4):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST4H4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST4H4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/641 Interacting proteins for HIST4H4 (P628051, 2, 3 ENSP000003507674) via UniProtKB, MINT, STRING, and/or I2D (see all 641)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3EP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST4H4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIST4H4 for compounds           About GeneDecksing

    EMD Millipore small molecules for HIST4H4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST4H4 (H4)

    10/49 Novoseek inferred chemical compound relationships for HIST4H4 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scriptaid 76.8 2 16391833 (1), 14620913 (1)
    apicidin 75.9 3 14985106 (1), 17258775 (1), 17203205 (1)
    depsipeptide 71.9 4 17286952 (1), 17610380 (1), 12592335 (1), 15024582 (1)
    lysine 66.7 21 18418072 (1), 19801601 (1), 9820584 (1), 12724220 (1) (see all 18)
    butyrate 64.7 19 7646441 (4), 9214697 (1), 15261456 (1), 10716680 (1) (see all 13)
    phenylbutyrate 61.1 2 14871995 (1), 19723072 (1)
    suberoylanilide hydroxamic acid 56.1 1 16928817 (1)
    5-aza-2'deoxycytidine 55.2 2 10319871 (1)
    nabu 46.3 3 15812237 (1), 9826026 (1)
    valproic acid 43.3 7 18847317 (1), 17534580 (1), 15735039 (1), 17522015 (1)

    Search CenterWatch for drugs/clinical trials and news about HIST4H4 / H4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST4H4 gene: 
    NM_175054.2  

    Unigene Cluster for HIST4H4:

    Histone cluster 4, H4
    Hs.745457  [show with all ESTs]
    Unigene Representative Sequence: EL735498
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358064(uc001rce.3) ENST00000537096 ENST00000541592 ENST00000537853
    ENST00000540565 ENST00000539745(uc001rcf.4)
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST4H4
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    Additional mRNA sequence: AK311916.1 

    1 DOTS entry:

    DT.91698592 

    18 AceView cDNA sequences:

    BI063334 NM_175054 CB961253 BQ423204 CB959866 BG436099 AA318102 BC020884 
    AV729148 BX505653 BQ953651 BM907072 BF746651 C17554 CB963564 BQ062528 
    AV764584 BQ229008 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST4H4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST4H4 Expression
    About this image


    See HIST4H4 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.745457
        SABiosciences Custom PCR Arrays for HIST4H4
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST4H4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST4H4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST4H4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIST4H4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist4h45 histone cluster 4, H4   --   6 (66.72 cM) 136801553 
    chicken
    (Gallus gallus)
    Aves LOC7701421 histone H4-like 84.79(n)
    100(a)
      770142  XM_001233179.2  XP_001233180.1 
    lizard
    (Anolis carolinensis)
    Reptilia HIST1H4I6
    HIST1H4I6
    (see all 3)
    Histone H4
    (see all 3)
    100(a)
    100(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    GL343279.1(558066-558377)
    GL343466.1(317297-317608)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1534091 zgc:153409 80.91(n)
    99.03(a)
      767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338771 CG33877-PA 79.29(n)
    98.06(a)
      3772211  NM_001032191.1  NP_001027362.1 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AER012C1 AER012Cp 77.99(n)
    90.29(a)
      4621072  NM_210226.1  NP_984872.1 


    ENSEMBL Gene Tree for HIST4H4 (if available)
    TreeFam Gene Tree for HIST4H4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST4H4 gene
    HIST1H4A1 2  HIST1H4I1 2  HIST1H4K1 2  HIST1H4E1 2  HIST1H4J1 2  HIST1H4D1 2  HIST1H4B1 2  HIST1H4L1 2  
    HIST1H4H1 2  HIST2H4A1 2  HIST1H4C1 2  HIST2H4B1 2  HIST1H4F1 2  HIST1H4G2  
    3 SIMAP similar genes for HIST4H4 using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4L    HIST1H4H    HIST1H4G

    HIST4H4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/56 SNPs in HIST4H4 are shown (see all 56)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157688581,2
    C,F--14923164(+) CTAGAG/ACTGCA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs743491871,2
    C,F--14923180(+) CTTTCG/CGGCTT 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1488702591,2
    --14923189(+) TTGCAA/GGTAGC 1 -- ds50010--------
    rs1387658031,2
    C--14923265(+) GCGTG-/CACGCT 1 -- ds50010--------
    rs740681191,2
    C,F--14923295(+) GAAGTC/AACCTA 1 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs1858178211,2
    --14923320(+) TGGAAA/GCCATC 1 -- ds50010--------
    rs1480575011,2
    C--14923332(+) GATACA/GTGCTT 1 -- ds50010--------
    rs169102461,2
    C,F--14923347(+) GCCAAC/AGACTC 1 -- ds50014Minor allele frequency- A:0.02NA EA 262
    rs1876742761,2
    --14923437(+) TTTTGA/GGAGGT 1 -- ds50010--------
    rs1113192291,2
    C--14923507(+) TTGAGG/ATCTAG 1 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for HIST4H4 (14920933 - 14924065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST4H4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898817CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615069    OMIM disorders: --

    20/40 diseases for HIST4H4 (see all 40):    About MalaCards
    neuronal ceroid lipofuscinosis    fragile x syndrome    cutaneous t cell lymphoma    skin cancer
    choriocarcinoma    medulloblastoma    esophageal squamous cell carcinoma    colon cancer
    hepatocellular carcinoma    non-hodgkin lymphoma    hodgkin's lymphoma    b-cell lymphomas
    retinoblastoma    cervical cancer    ovarian cancer    esophagitis
    melanoma    glioblastoma    systemic lupus erythematosus    adenoma

    1 disease from the University of Copenhagen DISEASES database for HIST4H4:
    Cancer

    HIST4H4 for disorders           About GeneDecksing

    10/22 Novoseek inferred disease relationships for HIST4H4 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 32.1 13 15765097 (4), 19961487 (2), 16699174 (1), 12579268 (1) (see all 7)
    retinoblastoma 27.4 1 17610380 (1)
    tumors 27.3 15 16863736 (2), 12724227 (1), 16001982 (1), 19086847 (1) (see all 14)
    lung carcinoma 22.3 5 19596041 (1), 19376846 (1), 18974389 (1)
    colon cancer 18.5 1 12975486 (1)
    leukemia 10.3 4 16409301 (1), 19578722 (1), 2133550 (1), 18295477 (1)
    breast cancer 8.97 8 16861913 (2), 11682064 (2), 16322686 (1), 16707467 (1)
    myeloid leukemia chronic 8.5 2 19962902 (1), 18413791 (1)
    gastric carcinoma 7.61 5 12385581 (3), 15586362 (1)
    metastasis 5.24 1 12385581 (1)


    Export disorders for HIST4H4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST4H4 gene, integrated from 9 sources (see all 439):
    (articles sorted by number of sources associating them with HIST4H4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)1, 2 Kang B....Zhang Z. (2011)
    3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)1, 2 Yan Q....Shipp M.A. (2009)
    4. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2 Braastad C.D....Stein G.S. (2004)
    5. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2 Wang Y.... Coonrod S.A. (2004)
    6. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (2003)
    7. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (1987)
    8. Acetylated histone H4 is reduced in human gastric adenomas and carcinomas. (PubMed id 12385581)1, 9 Ono S....Yasui W. (2002)
    9. Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. (PubMed id 15095300)1, 9 Toh Y....Nicolson G.L. (2004)
    10. Histone H4 is a major component of the antimicrobial action of human sebocytes. (PubMed id 19536143)1, 9 Lee D.Y....Gallo R.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 121504 HGNC: 20510 AceView: HIST4H4 Ensembl:ENSG00000197837 euGenes: HUgn121504
    ECgene: HIST4H4 Kegg: 121504 H-InvDB: HIST4H4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST4H4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST4H4 gene:
    Search GeneIP for patents involving HIST4H4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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