Aliases for HIST4H4 Gene
Aliases for HIST4H4 Gene
- Histone Cluster 4 H4 2 3 5
- Histone 4, H4 2 3
- HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
- Histone Cluster 4, H4 2
- Histone H4 3
- HIST2H4 4
- H4FA 4
- H4/A 4
- H4/B 4
- H4/C 4
- H4/D 4
- H4/E 4
- H4/G 4
- H4/H 4
- H4/I 4
- H4/J 4
- H4/K 4
- H4/M 4
External Ids for HIST4H4 Gene
- HGNC: 20510
- Entrez Gene: 121504
- Ensembl: ENSG00000197837
- OMIM: 615069
- UniProtKB: P62805
Previous GeneCards Identifiers for HIST4H4 Gene
- GC12M015065
- GC12M014822
- GC12M014814
- GC12M014692
- GC12M014920
Summaries for HIST4H4 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST4H4 Gene
HIST4H4 (Histone Cluster 4 H4) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4K.
UniProtKB/Swiss-Prot for HIST4H4 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST4H4 Gene
Genomics for HIST4H4 Gene
Regulatory Elements for HIST4H4 Gene
Enhancers for HIST4H4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST4H4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST4H4 gene promoter:
Regulatory Element Products
Genomic Location for HIST4H4 Gene
- Chromosome:
- 12
- Start:
- 14,767,999 bp from pter
- End:
- 14,771,131 bp from pter
- Size:
- 3,133 bases
- Orientation:
- Minus strand
Genomic View for HIST4H4 Gene
Genes around HIST4H4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.3 by Ensembl
- 12p12.3 by Entrez Gene
- 12p12.3 by HGNC
HIST4H4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST4H4 Gene
Proteins for HIST4H4 Gene
-
Protein details for HIST4H4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for HIST4H4 Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
Protein Expression for HIST4H4 Gene
Post-translational modifications for HIST4H4 Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Sumoylated, which is associated with transcriptional repression.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
- Modification sites at PhosphoSitePlus
Other Protein References for HIST4H4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST4H4 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST4H4
- R&D Systems Antibodies for HIST4H4 (Histone H4)
-
Custom Antibody ServicesOriGene Antibodies for HIST4H4
- Novus Biologicals Antibodies for HIST4H4
- antibodies-online Antibodies for HIST4H4: See all 4
- GeneTex HIST4H4 antibody for HIST4H4
- GeneTex Slc1a1 antibody for HIST4H4
Protein Products
- EMD Millipore Purified and/or Recombinant HIST4H4 Protein
-
OriGene Purified Proteins for HIST4H4
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST4H4
- Origene Custom Protein Services for HIST4H4
- antibodies-online Proteins for HIST4H4: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIST4H4
Assay Products
- EMD Millipore Kits and Assays for HIST4H4
No data available for DME Specific Peptides for HIST4H4 Gene
Domains & Families for HIST4H4 Gene
Gene Families for HIST4H4 Gene
- HGNC:
Protein Domains for HIST4H4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST4H4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
Function for HIST4H4 Gene
Molecular function for HIST4H4 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS,IBA | 3035717 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0042393 | histone binding | IPI | 20498094 |
Phenotypes for HIST4H4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST4H4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST4H4 gene
- Search ViGene Biosciences for HIST4H4
CRISPR Products
-
OriGene CRISPR knockouts for HIST4H4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST4H4
- GenScript: Design CRISPR guide RNA sequences for HIST4H4
miRNA for HIST4H4 Gene
- miRTarBase miRNAs that target HIST4H4
miRNA Products
- Search ViGene Biosciences for HIST4H4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST4H4
- Browse OriGene Inhibitory RNA Products For HIST4H4
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST4H4 gene
Clone Products
-
OriGene ORF clones in human for HIST4H4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST4H4
Cell Line Products
-
Horizon Cell Lines for HIST4H4
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST4H4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST4H4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST4H4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST4H4 Gene
Localization for HIST4H4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST4H4 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IBA | -- |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST4H4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST4H4 Gene
1 GeneTex pathway for HIST4H4 Gene
3 BioSystems pathways for HIST4H4 Gene
66 Reactome pathways for HIST4H4 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST4H4 Gene
4 GeneGo (Thomson Reuters) pathways for HIST4H4 Gene
1 R&D Systems pathway for HIST4H4 Gene
Interacting Proteins for HIST4H4 Gene
Selected Interacting proteins:
ENSP00000350767
P62805-H4_HUMAN
for HIST4H4 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
No data available for SIGNOR curated interactions for HIST4H4 Gene
Transcripts for HIST4H4 Gene
mRNA/cDNA for HIST4H4 Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (18) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST4H4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST4H4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST4H4
- GenScript: Design CRISPR guide RNA sequences for HIST4H4
miRNA Products
- Search ViGene Biosciences for HIST4H4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST4H4
- Browse OriGene Inhibitory RNA Products For HIST4H4
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST4H4 gene
Clone Products
-
OriGene ORF clones in human for HIST4H4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST4H4
Flow Cytometry Products
Expression for HIST4H4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST4H4 Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST4H4 Gene:
HIST4H4SOURCE GeneReport for Unigene cluster for HIST4H4 Gene:
Hs.745457Evidence on tissue expression from TISSUES for HIST4H4 Gene
- Liver(4.5)
- Nervous system(4.5)
- Eye(4.2)
- Blood(2.3)
- Intestine(2.3)
- Kidney(2.2)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HIST4H4
-
OriGene qPCR primer pairs for HIST4H4
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST4H4 Gene
Orthologs for HIST4H4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HIST4H4 35 |
|
OneToOne | |
| LOC619094 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | HIST4H4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIST4H4 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | HIST4H4 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC680097 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h4i 34 16 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101734426 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-113a14.17 35 |
|
ManyToMany | |
| LOC562770 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012574 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33903 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | his-5 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHF1 37 |
|
|
|
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G59690 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0462700 34 |
|
- Species where no ortholog for HIST4H4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIST4H4 Gene
Paralogs for HIST4H4 Gene
(3) SIMAP similar genes for HIST4H4 Gene using alignment to 1 proteins:
Variants for HIST4H4 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000511644 | -- | 14,771,126(+) | CTGCC(C/T)ACTGT | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1001056933 | -- | 14,770,321(+) | CCGCC(C/G)TTGAC | intron-variant, downstream-variant-500B, utr-variant-5-prime | |
| rs1002467188 | -- | 14,770,580(+) | CTAGT(C/T)CTCCC | intron-variant, downstream-variant-500B, utr-variant-5-prime | |
| rs1003052524 | -- | 14,772,524(+) | GAGGT(C/T)AGGAG | intron-variant, upstream-variant-2KB | |
| rs1003348445 | -- | 14,771,235(+) | ATGCT(A/G)TAGTT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
28.97% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST4H4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST4H4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HIST4H4 Gene
Disorders for HIST4H4 Gene
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
Relevant External Links for HIST4H4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST4H4
No disorders were found for HIST4H4 Gene.
No data available for MalaCards and Genatlas for HIST4H4 Gene
Publications for HIST4H4 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PMID: 21724829) Kang B. … Zhang Z. (Genes Dev. 2011) 3 4 64
- BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q. … Shipp M.A. (Mol. Cell 2009) 3 4 64
- Analysis of interaction partners of H4 histone by a new proteomics approach. (PMID: 19862764) Saade E. … Ogryzko V. (Proteomics 2009) 3 22 64
- TFIIH-associated Cdk7 kinase functions in phosphorylation of C- terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. (PMID: 19667075) Glover-Cutter K. … Bentley D.L. (Mol. Cell. Biol. 2009) 3 22 64
Products for HIST4H4 Gene
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- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HIST4H4
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HIST4H4
- Novus Biologicals proteins and lysates for HIST4H4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST4H4
- antibodies-online Antibodies for HIST4H4: See all 4
- Search antibodies-online for kits
- antibodies-online Proteins for HIST4H4: See all 3
- Search antibodies-online for peptides
- GeneTex Slc1a1 antibody for HIST4H4
- GeneTex HIST4H4 antibody for HIST4H4
- Search GeneTex for Proteins for HIST4H4
- ViGene Biosciences adenoviral particle packaged cDNA for HIST4H4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST4H4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIST4H4 gene
- Search ViGene Biosciences for HIST4H4
- Search Santa Cruz Biotechnology (SCBT) for HIST4H4 Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST4H4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST4H4
- Horizon Cell Lines for HIST4H4
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST4H4
- VectorBuilder custom plasmid, inducible vectors for HIST4H4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST4H4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST4H4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer