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Aliases for HIST4H4 Gene

Aliases for HIST4H4 Gene

  • Histone Cluster 4 H4 2 3 5
  • Histone 4, H4 2 3
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • Histone Cluster 4, H4 2
  • Histone H4 3
  • HIST2H4 4
  • H4FA 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4
  • H4/P 3

External Ids for HIST4H4 Gene

Previous GeneCards Identifiers for HIST4H4 Gene

  • GC12M015065
  • GC12M014822
  • GC12M014814
  • GC12M014692
  • GC12M014920

Summaries for HIST4H4 Gene

Entrez Gene Summary for HIST4H4 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST4H4 Gene

HIST4H4 (Histone Cluster 4 H4) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4K.

UniProtKB/Swiss-Prot for HIST4H4 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST4H4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST4H4 Gene

Genomics for HIST4H4 Gene

Regulatory Elements for HIST4H4 Gene

Enhancers for HIST4H4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G014255 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 21.9 +512.3 512304 7.2 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF548 SP3 MEF2D ZNF585B GLIS1 ATF7IP ENSG00000261324 HIST4H4 RPL30P11 H2AFJ WBP11 PLBD1 GC12P014255 PIR56629 GC12M014297
GH12G015710 1.5 Ensembl ENCODE dbSUPER 15.4 -941.3 -941315 3.3 HNRNPUL1 FOXA2 ATF1 ZFP64 YY1 KLF7 ZNF263 ZNF202 SP5 MXD4 SUPT16HP1 WBP11 HIST4H4 ENSG00000261324 RNU6-251P EPS8 ENSG00000256564 GC12M015672 ENSG00000255565
GH12G014945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -184.2 -184183 19.1 HDGF PKNOX1 ATF1 FOXA2 WRNIP1 SIN3A YBX1 YY1 ZNF766 GATA2 ARHGDIB ERP27 PDE6H WBP11 ART4 H2AFJ HIST4H4 SMCO3 C12orf60 ENSG00000256339
GH12G014282 1.4 Ensembl ENCODE dbSUPER 11.2 +487.4 487394 2.7 PKNOX1 TCF12 GATA2 CBX5 JUNB TBX21 ZNF592 CREB3 SMARCA4 PBX2 ENSG00000261324 HIST4H4 GC12M014297 PIR56629 GC12P014255
GH12G014845 1 Ensembl ENCODE 12.6 -74.4 -74370 0.6 CTCF ARNT YBX1 ZNF2 RAD21 ZNF316 ZNF366 ZNF143 SMC3 NFE2 ENSG00000261324 HIST4H4 ATF7IP H2AFJ ART4 GC12M014862
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST4H4 on UCSC Golden Path with GeneCards custom track

Promoters for HIST4H4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000049158 831 3401 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for HIST4H4 Gene

Chromosome:
12
Start:
14,767,999 bp from pter
End:
14,771,131 bp from pter
Size:
3,133 bases
Orientation:
Minus strand

Genomic View for HIST4H4 Gene

Genes around HIST4H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST4H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST4H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST4H4 Gene

Proteins for HIST4H4 Gene

  • Protein details for HIST4H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST4H4 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST4H4 Gene

neXtProt entry for HIST4H4 Gene

Post-translational modifications for HIST4H4 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST4H4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST4H4 Gene

Domains & Families for HIST4H4 Gene

Gene Families for HIST4H4 Gene

Protein Domains for HIST4H4 Gene

Suggested Antigen Peptide Sequences for HIST4H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST4H4: view

Function for HIST4H4 Gene

Molecular function for HIST4H4 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IBA 3035717
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IPI 20498094
genes like me logo Genes that share ontologies with HIST4H4: view
genes like me logo Genes that share phenotypes with HIST4H4: view

Animal Model Products

miRNA for HIST4H4 Gene

miRTarBase miRNAs that target HIST4H4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST4H4 Gene

Localization for HIST4H4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST4H4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IBA --
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST4H4: view

Pathways & Interactions for HIST4H4 Gene

SuperPathways for HIST4H4 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST4H4: view

Interacting Proteins for HIST4H4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350767%0d%0a9606.ENSP00000336868%0d%0a9606.ENSP00000349430%0d%0a9606.ENSP00000274764%0d%0a9606.ENSP00000358151%0d%0a9606.ENSP00000350580%0d%0a
Selected Interacting proteins: ENSP00000350767 P62805-H4_HUMAN for HIST4H4 Gene via STRING MINT UniProtKB IID

Symbol External ID(s) Details
TP53BP1
KDM4A
BRD2
COPRS
PHF20

Gene Ontology (GO) - Biological Process for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST4H4: view

No data available for SIGNOR curated interactions for HIST4H4 Gene

Drugs & Compounds for HIST4H4 Gene

(29) Drugs for HIST4H4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(20) Additional Compounds for HIST4H4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HIST4H4: view

Transcripts for HIST4H4 Gene

mRNA/cDNA for HIST4H4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST4H4 Gene

Histone cluster 4, H4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST4H4 Gene

No ASD Table

Relevant External Links for HIST4H4 Gene

GeneLoc Exon Structure for
HIST4H4
ECgene alternative splicing isoforms for
HIST4H4

Expression for HIST4H4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST4H4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST4H4 Gene



Protein tissue co-expression partners for HIST4H4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST4H4 Gene:

HIST4H4

SOURCE GeneReport for Unigene cluster for HIST4H4 Gene:

Hs.745457

Evidence on tissue expression from TISSUES for HIST4H4 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Eye(4.2)
  • Blood(2.3)
  • Intestine(2.3)
  • Kidney(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with HIST4H4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST4H4 Gene

Orthologs for HIST4H4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST4H4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIST4H4 35
  • 100 (a)
OneToOne
LOC619094 34
  • 81.23 (n)
dog
(Canis familiaris)
Mammalia HIST4H4 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIST4H4 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIST4H4 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680097 34
  • 84.14 (n)
mouse
(Mus musculus)
Mammalia Hist1h4i 34 16
  • 83.5 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734426 34
  • 81.23 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.17 35
  • 100 (a)
ManyToMany
LOC562770 34
  • 80.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012574 34
  • 80.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33903 34
  • 79.61 (n)
worm
(Caenorhabditis elegans)
Secernentea his-5 34
  • 78.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59690 34
  • 77.35 (n)
rice
(Oryza sativa)
Liliopsida Os05g0462700 34
  • 81.55 (n)
Species where no ortholog for HIST4H4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST4H4 Gene

ENSEMBL:
Gene Tree for HIST4H4 (if available)
TreeFam:
Gene Tree for HIST4H4 (if available)

Paralogs for HIST4H4 Gene

(3) SIMAP similar genes for HIST4H4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST4H4: view

Variants for HIST4H4 Gene

Sequence variations from dbSNP and Humsavar for HIST4H4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000511644 -- 14,771,126(+) CTGCC(C/T)ACTGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001056933 -- 14,770,321(+) CCGCC(C/G)TTGAC intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1002467188 -- 14,770,580(+) CTAGT(C/T)CTCCC intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1003052524 -- 14,772,524(+) GAGGT(C/T)AGGAG intron-variant, upstream-variant-2KB
rs1003348445 -- 14,771,235(+) ATGCT(A/G)TAGTT intron-variant, upstream-variant-2KB

Variation tolerance for HIST4H4 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST4H4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST4H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HIST4H4 Gene

Disorders for HIST4H4 Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

Relevant External Links for HIST4H4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST4H4

No disorders were found for HIST4H4 Gene.

No data available for MalaCards and Genatlas for HIST4H4 Gene

Publications for HIST4H4 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  2. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PMID: 21724829) Kang B. … Zhang Z. (Genes Dev. 2011) 3 4 64
  3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q. … Shipp M.A. (Mol. Cell 2009) 3 4 64
  4. Analysis of interaction partners of H4 histone by a new proteomics approach. (PMID: 19862764) Saade E. … Ogryzko V. (Proteomics 2009) 3 22 64
  5. TFIIH-associated Cdk7 kinase functions in phosphorylation of C- terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. (PMID: 19667075) Glover-Cutter K. … Bentley D.L. (Mol. Cell. Biol. 2009) 3 22 64

Products for HIST4H4 Gene

Sources for HIST4H4 Gene

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