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Aliases for HIST4H4 Gene

Aliases for HIST4H4 Gene

  • Histone Cluster 4, H4 2 3
  • Histone 4, H4 2 3
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • Histone H4 3
  • HIST2H4 4
  • H4/G 4
  • H4FG 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4
  • H4/P 3

External Ids for HIST4H4 Gene

Previous GeneCards Identifiers for HIST4H4 Gene

  • GC12M015065
  • GC12M014822
  • GC12M014814
  • GC12M014692
  • GC12M014920

Summaries for HIST4H4 Gene

Entrez Gene Summary for HIST4H4 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST4H4 Gene

HIST4H4 (Histone Cluster 4, H4) is a Protein Coding gene. Diseases associated with HIST4H4 include colorectal cancer. Among its related pathways are Disease and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is HIST1H4C.

UniProtKB/Swiss-Prot for HIST4H4 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST4H4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST4H4 Gene

Genomics for HIST4H4 Gene

Regulatory Elements for HIST4H4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST4H4 Gene

Start:
14,767,999 bp from pter
End:
14,771,131 bp from pter
Size:
3,133 bases
Orientation:
Minus strand

Genomic View for HIST4H4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST4H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST4H4 Gene

Proteins for HIST4H4 Gene

  • Protein details for HIST4H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST4H4 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST4H4 Gene

neXtProt entry for HIST4H4 Gene

Proteomics data for HIST4H4 Gene at MOPED

Post-translational modifications for HIST4H4 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST4H4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST4H4 Gene

Domains for HIST4H4 Gene

Gene Families for HIST4H4 Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST4H4 Gene

Suggested Antigen Peptide Sequences for HIST4H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • P62805
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST4H4: view

Function for HIST4H4 Gene

Molecular function for HIST4H4 Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 3035717
GO:0005515 protein binding IPI 10220385
GO:0035575 histone demethylase activity (H4-K20 specific) TAS --
GO:0042393 histone binding IPI 20498094
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST4H4: view

miRNA for HIST4H4 Gene

miRTarBase miRNAs that target HIST4H4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST4H4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST4H4 Gene

Localization for HIST4H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST4H4 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST4H4 Gene COMPARTMENTS Subcellular localization image for HIST4H4 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 4

Gene Ontology (GO) - Cellular Components for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000786 nucleosome TAS 3035717
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 14585971
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST4H4: view

Pathways for HIST4H4 Gene

genes like me logo Genes that share pathways with HIST4H4: view

Gene Ontology (GO) - Biological Process for HIST4H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000723 telomere maintenance TAS --
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly TAS --
genes like me logo Genes that share ontologies with HIST4H4: view

Compounds for HIST4H4 Gene

(49) Novoseek inferred chemical compound relationships for HIST4H4 Gene

Compound -log(P) Hits PubMed IDs
scriptaid 76.8 2
apicidin 75.9 3
depsipeptide 71.9 4
lysine 66.7 18
butyrate 64.7 16
genes like me logo Genes that share compounds with HIST4H4: view

Transcripts for HIST4H4 Gene

mRNA/cDNA for HIST4H4 Gene

(18) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST4H4 Gene

Histone cluster 4, H4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST4H4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST4H4 Gene

No ASD Table

Relevant External Links for HIST4H4 Gene

GeneLoc Exon Structure for
HIST4H4
ECgene alternative splicing isoforms for
HIST4H4

Expression for HIST4H4 Gene

mRNA expression in normal human tissues for HIST4H4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST4H4 Gene

SOURCE GeneReport for Unigene cluster for HIST4H4 Gene Hs.745457

genes like me logo Genes that share expressions with HIST4H4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST4H4 Gene

Orthologs for HIST4H4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST4H4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST4H4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIST4H4 36
  • 100 (a)
OneToOne
LOC619094 35
  • 81.23 (n)
  • 99.03 (a)
dog
(Canis familiaris)
Mammalia HIST4H4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist1h4i 35
  • 83.5 (n)
  • 100 (a)
Hist4h4 16
platypus
(Ornithorhynchus anatinus)
Mammalia HIST4H4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680097 35
  • 84.14 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734426 35
  • 81.23 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562770 35
  • 80.91 (n)
  • 100 (a)
si:ch211-113a14.17 36
  • 100 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012574 35
  • 80.91 (n)
  • 99.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33903 35
  • 79.61 (n)
  • 99.03 (a)
worm
(Caenorhabditis elegans)
Secernentea his-5 35
  • 78.32 (n)
  • 99.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59690 35
  • 77.35 (n)
  • 98.06 (a)
rice
(Oryza sativa)
Liliopsida Os05g0462700 35
  • 81.55 (n)
  • 98.06 (a)
Species with no ortholog for HIST4H4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST4H4 Gene

ENSEMBL:
Gene Tree for HIST4H4 (if available)
TreeFam:
Gene Tree for HIST4H4 (if available)

Paralogs for HIST4H4 Gene

Paralogs for HIST4H4 Gene

Selected SIMAP similar genes for HIST4H4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST4H4: view

Variants for HIST4H4 Gene

Sequence variations from dbSNP and Humsavar for HIST4H4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11056180 -- 14,770,342(+) CACCC(A/C)TGAAG downstream-variant-500B
rs11056181 -- 14,771,704(+) CCCGA(A/C)CCCCG upstream-variant-2KB
rs12818627 -- 14,770,588(+) CCCCG(C/T)GCCCG downstream-variant-500B
rs12819075 -- 14,771,294(+) TTGCT(C/G)TTTTG upstream-variant-2KB
rs16910246 -- 14,770,413(+) GCCAA(A/C)GACTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST4H4 Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294

Relevant External Links for HIST4H4 Gene

HapMap Linkage Disequilibrium report
HIST4H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST4H4 Gene

Disorders for HIST4H4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HIST4H4 Gene including...

Search for HIST4H4 Gene in MalaCards »

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

(1) University of Copenhagen DISEASES for HIST4H4 Gene

(22) Novoseek inferred disease relationships for HIST4H4 Gene

Disease -log(P) Hits PubMed IDs
cancer 32.1 11
retinoblastoma 27.4 1
tumors 27.3 15
lung carcinoma 22.3 3
colon cancer 18.5 1
genes like me logo Genes that share disorders with HIST4H4: view

Publications for HIST4H4 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  2. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PMID: 15345777) Wang Y. … Coonrod S.A. (Science 2004) 3 4
  3. Histone sumoylation is associated with transcriptional repression. (PMID: 14578449) Shiio Y. … Eisenman R.N. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U. … Nick H. (Science 1987) 3 4
  5. SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail. (PMID: 18418072) Yin Y. … Chang D.C. (Cell Cycle 2008) 3 23

Products for HIST4H4 Gene

Sources for HIST4H4 Gene

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