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HIST3H3 Gene

protein-coding GIFtS: 51

GC01M226679

histone cluster 3, H3
(Previous names: H3 histone family, member T, histone 3, H3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: H3FT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
H3.4 ^²
H3/g ^¹, ², ³
H3/t ^³
H3FT ^², ³, ⁵
H3T ^⁵
H3t ^¹, ², ³
MGC126886 ^²
MGC126888 ^²
OTTHUMP00000037945 ^²

Descriptions
H3 histone family, member T ^¹, ²
histone 3, H3 ^¹, ²
histone cluster 3, H3 ^²

External Ids
HGNC: 4778¹
Entrez Gene: 8290²
UniProtKB: Q16695³
Ensembl: ENSG00000168148⁷

Search outside databases for aliases for HIST3H3 gene

Previous GC identifers: GC01M224351 GC01M224998 GC01M225587 GC01M224919

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HIST3H3:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the

chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around

a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The

chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA

between the nucleosomes to form higher order chromatin structures. This gene is intronless and

encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead,

they contain a palindromic termination element. This gene is located separately from the other H3

genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq]

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting

DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby

play a central role in transcription regulation, DNA repair, DNA replication and chromosomal

stability. DNA accessibility is regulated via a complex set of post-translational modifications of

histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST3H3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HIST3H3 gene

Entrez Gene cytogenetic band: 1q42 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.13

HIST3H3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M226679: (about GC identifiers)

Start:	226,679,169 bp from pter
End:	226,679,649 bp from pter
Size:	481 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004559.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695 (See protein sequence)

Recommended Name: Histone H3.1t

Size: 136 amino acids; 15508 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4

assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps

approximately 147 bp of DNA

Subcellular location: Nucleus

Developmental stage: Expressed during S phase, then expression strongly decreases as cell division

slows down during the process of differentiation

PDB structures from and Proteopedia :

2V1D (3D)

Secondary accessions: Q6FGU4

Post-translational modifications:

Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs

methylation at Arg-9 (H3R8sme2). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors

methylation at Arg-18 (H3R17me) (By similarity)¹

Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses

transcription (By similarity)¹

Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric

dimethylation at Arg-9 (H3R8sme2) by PRMT5 is linked to gene repression. Asymmetric dimethylation

at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5

methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their

transcription state and is enriched on inactive promoters, while it is absent on active promoters

(By similarity)¹

Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation.

Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at

Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific

target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene

repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and

CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.

Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B

at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X

chromosome chromatin (By similarity)¹

Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during

anaphase. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early

anaphase. Phosphorylated at Ser-11 during the whole mitosis. Phosphorylation at Ser-11 (H3S10ph),

which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates

acetylation of H3 and H4. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB

during mitosis or upon ultraviolet B irradiation (By similarity)¹

Phosphorylation at Ser-11 (H3S10ph) is crucial for chromosome condensation and cell-cycle

progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) is

important during interphase because it enables the transcription of genes following external

stimulation, like stress or growth factors. Phosphorylation at Ser-11 (H3S10ph) is also an

essential regulatory mechanism for neoplastic cell transformation. Phosphorylation at Ser-11

(H3S10ph) by AURKB/Aurora-B mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from

heterochromatin¹

Ubiquitinated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003484.1

ENSEMBL proteins:

ENSP00000355657

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Histone H3 (AA substitution))
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: HIST3H3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	NAS	--
GO:0005634	nucleus	IEA	--
GO:0005694	chromosome	IEA	--

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Antibodies for HIST3H3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HIST3H3
	Sigma-Aldrich Antibody Arrays and Antibodies for HIST3H3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Histone H3 (AA substitution)), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for HIST3H3

Assays for HIST3H3:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of HIST3H3
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16695

ProtoNet protein and cluster: Q16695

1 Blocks protein family: IPB000164 Histone H3

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695

Similarity: Belongs to the histone H3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HIST3H3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HIST3H3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003493

Applied Biosystems Silencer® siRNAs for HIST3H3

Sigma-Aldrich siRNA for HIST3H3

Sigma-Aldrich shRNA for HIST3H3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003493
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003493
untagged cDNA clone in CMV expression vector: NM_003493

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003493

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting

DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby

play a central role in transcription regulation, DNA repair, DNA replication and chromosomal

stability. DNA accessibility is regulated via a complex set of post-translational modifications of

histones, also called histone code, and nucleosome remodeling

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	--
GO:0005515	protein binding	IPI	17537733 17567753

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for HIST3H3 (Your Favorite Gene powered by Ingenuity)

Estrogen Receptor Signaling
p38 MAPK Signaling
ERK/MAPK Signaling

GeneDecks HIST3H3 for the pathways selected above

About GeneDecksing

5/20 Interacting proteins for HIST3H3 (Q16695^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 20 )
Interactant Interaction Details
GeneCard External ID(s)
AOF2 O60341¹ EBI-358900, EBI-710124
JMJD2A O75164¹ EBI-358900, EBI-936709
HIST1H4A P62805² MINT-4950280 MINT-4950315
HIST1H4B P62805² MINT-4950280 MINT-4950315
HIST1H4C P62805² MINT-4950280 MINT-4950315
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly NAS --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HIST3H3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HIST3H3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HIST3H3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003493

Sigma-Aldrich siRNA for HIST3H3

Sigma-Aldrich shRNA for HIST3H3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003493

REFSEQ mRNAs for HIST3H3 gene:

NM_003493.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003493

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003493
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003493
                                 untagged cDNA clone in CMV expression vector: NM_003493

Additional cDNA sequence:

AK312217.1 BC069079.1 BC101837.1 BC101839.1 CR542013.1

1 DOTS entry:

DT.91953314

3 AceView cDNA sequences:

NM_003493 BC069079 CR542013

highest scoring ESTs for HIST3H3:

BC069079 BG900472 CR542013 NM_003493 BC101837 BC101839 DB026731 DB453485

Unigene Cluster for HIST3H3:

Histone cluster 3, H3

Hs.248171 [show with all ESTs]

Unigene Representative Sequence: DB026731

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000366696

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HIST3H3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HIST3H3

¹ / ² / ³

2 probe-sets matching HIST3H3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
208572_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003493	0.60	1.00	0.82	1
208572_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTAAGGACA

SOURCE GeneReport for Unigene cluster: Hs.248171
UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
Tissue specificity: Expressed in testicular cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HIST3H3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC488298¹	--	similar to histone 1, H2ai (predicted)	90.44(n) 97.06(a)	488298 XM_545420.2 XP_545420.2
chimpanzee (Pan troglodytes)	LOC471907¹	--	similar to histone H3	86.76(n) 97.06(a)	471907 XM_527285.2 XP_527285.2
cow (Bos taurus)	H3.1¹	--	histone H3.1	90.2(n) 97.06(a)	787528 XM_001253588.1 XP_001253589.1
rat (Rattus norvegicus)	LOC679994¹	--	similar to histone 1, H2ai	86.27(n) 97.06(a)	679994 XM_001055231.1 XP_001055231.1
mouse (Mus musculus)	Hist1h3h¹	--	histone cluster 1, H3h	88.48(n) 97.06(a)	319152 NM_178206.2 NP_835513.1

About this table Species with no ortholog for HIST3H3

ENSEMBL Gene Tree for HIST3H3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HIST3H3 gene

HIST1H3J² HIST1H3A²

Pseudogenes

6 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/26 NCBI SNPs in HIST3H3 are shown (see all 26 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1188473^1,2	A,C,F,H,O	226679067(+)	`GATTCG/ACCAGC`	1	--	ng5¹		5		MN EU EA WA	602
--	rs473316^1,2	A,C,F,H	226680746(+)	`CGGCTT/CAGATG`	1	--	ng3¹		4		EU EA WA	412
	rs1188474^1,2	A,C,F,O	226679675(+)	`CGCGGC/TGTCCT`	1	--	ng3¹ tfbs³		1		MN	184
--	rs1188480^1,2	H	226681620(+)	`ttatgT/Ctgccc`	1	--	ng3¹		4		EU EA WA	420
--	rs1188477^1,2	A	226680434(+)	`ctcccA/Gggttc`	1	--	ng3¹		0	--	--	--	--
--	rs3105114^1,2	A	226680065(+)	`gcccaA/Ggctgg`	1	--	ng3¹		0	--	--	--	--
--	rs10916309^1,2	C	226680847(+)	`CAGGTA/GTAGGA`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs2230656^1,2	C,F,H,O	226679461(-)	`CTAATA/CCGCAA`	1	I/I	syn¹ ese³		7		MN EA EU WA NA	1994
--	rs12084050^1,2	--	226678832(+)	`CCTAAC/TTGTAG`	1	--	ng5¹		0	--	--	--	--
--	rs73099665^1,2	--	226681350(+)	`TCCTCA/CCTCCC`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for HIST3H3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602820

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/74 PubMed articles for HIST3H3 gene (see all 74 ):

The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{2, 3, 4} Marzluff W.F....Maltais L.J. (2002)
A solitary human H3 histone gene on chromosome 1. (PubMed id 8834248)^{2, 3, 4} Albig W....Doenecke D. (1996)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)^{3, 4} Ong S.E.... Mann M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone. (PubMed id 18439419)³ Mochizuki K....Goda T. (2008)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
Nucleosome formation with the testis-specific histone H3 variant, H3t, by human nucleosome assembly proteins in vitro. (PubMed id 18281699)³ Tachiwana H....Kurumizaka H. (2008)
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. (PubMed id 18418385)³ Meyer K.D....Taatjes D.J. (2008)
Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions. (PubMed id 17320048)³ Chandrasekaran R. and Thompson M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8290	HGNC: 4778	AceView: HIST3H3	Ensembl:ENSG00000168148	euGenes: HUgn8290
ECgene: HIST3H3	H-InvDB: HIST3H3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HIST3H3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HIST3H3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HIST3H3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HIST3H3		Antibodies for HIST3H3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HIST3H3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (Histone H3 (AA substitution))

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	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for HIST3H3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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HIST3H3 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for HIST3H3

Summaries
for HIST3H3

Genomic Location
for HIST3H3

Proteins
for HIST3H3

Protein Domains/
Families
for HIST3H3

Gene Function
for HIST3H3

Pathways & Interactions
for HIST3H3

Drugs & Compounds
for HIST3H3

Transcripts
for HIST3H3

Expression
for HIST3H3

Orthologs
for HIST3H3

Paralogs
for HIST3H3

SNPs/Variants
for HIST3H3

Disorders & Mutations
for HIST3H3

Medical News
for HIST3H3

Publications
for HIST3H3

Search for HIST3H3

Genome Databases showing HIST3H3

Other Databases showing HIST3H3

Specialized Databases showing HIST3H3

Licensable Technologies
for HIST3H3

Services
for HIST3H3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HIST3H3 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor HIST3H3

Summariesfor HIST3H3

Genomic Locationfor HIST3H3

Proteinsfor HIST3H3

Protein Domains/Familiesfor HIST3H3

Gene Functionfor HIST3H3

Pathways & Interactionsfor HIST3H3

Drugs & Compoundsfor HIST3H3

Transcriptsfor HIST3H3

Expression for HIST3H3

Orthologsfor HIST3H3

Paralogsfor HIST3H3

SNPs/Variantsfor HIST3H3

Disorders & Mutationsfor HIST3H3

Medical Newsfor HIST3H3

Publicationsfor HIST3H3

Search for HIST3H3

Genome Databases showing HIST3H3

Other Databases showing HIST3H3

Specialized Databases showing HIST3H3

Licensable Technologiesfor HIST3H3

Servicesfor HIST3H3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HIST3H3

Summaries
for HIST3H3

Genomic Location
for HIST3H3

Proteins
for HIST3H3

Protein Domains/
Families
for HIST3H3

Gene Function
for HIST3H3

Pathways & Interactions
for HIST3H3

Drugs & Compounds
for HIST3H3

Transcripts
for HIST3H3

Expression
for HIST3H3

Orthologs
for HIST3H3

Paralogs
for HIST3H3

SNPs/Variants
for HIST3H3

Disorders & Mutations
for HIST3H3

Medical News
for HIST3H3

Publications
for HIST3H3

Licensable Technologies
for HIST3H3

Services
for HIST3H3