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HIST3H3 Gene

protein-coding   GIFtS: 57
GCID: GC01M228612

Histone Cluster 3, H3

(Previous names: H3 histone family, member T, histone 3, H3)
(Previous symbol: H3FT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 3, H31 2     H3/t2 3
H3FT1 2 3 5     H3t2 3
H3 Histone Family, Member T1 2     H3.42
Histone 3, H31 2     Histone H3.1t2
H3/g2 3     H3T5

External Ids:    HGNC: 47781   Entrez Gene: 82902   Ensembl: ENSG000001681487   OMIM: 6028205   UniProtKB: Q166953   

Export aliases for HIST3H3 gene to outside databases

Previous GC identifers: GC01M224351 GC01M224998 GC01M225587 GC01M224919 GC01M226679 GC01M199127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST3H3 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene
lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from
the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST3H3 Gene:
HIST3H3 (histone cluster 3, H3) is a protein-coding gene. Diseases associated with HIST3H3 include nasopharyngitis, and huntington's disease. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST2H3C.

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST3H3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST3H3 gene promoter:
         NF-YB   CBF-B   CBF-A   Pax-5   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST3H3 promoter sequence
   Search Chromatin IP Primers for HIST3H3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST3H3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

HIST3H3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST3H3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228612:  view genomic region     (about GC identifiers)

Start:
228,612,546 bp from pter      End:
228,613,026 bp from pter
Size:
481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695 (See protein sequence)
Recommended Name: Histone H3.1t  
Size: 136 amino acids; 15508 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down
during the process of differentiation
5 PDB 3D structures from and Proteopedia for HIST3H3:
2V1D (3D)        2YBP (3D)        2YBS (3D)        3A6N (3D)        3T6R (3D)    
Secondary accessions: B2R5K3 Q6FGU4

Explore the universe of human proteins at neXtProt for HIST3H3: NX_Q16695

Explore proteomics data for HIST3H3 at MOPED

Post-translational modifications: 

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).
    Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the
    surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By
    similarity)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription
    (By similarity)1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at
    Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is
    linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is
    present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while
    it is absent on active promoters (By similarity)1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated
    with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me)
    and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1
    proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3
    and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at
    'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
    Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for
    DNA replication (By similarity)1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression
    during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important
    during interphase because it enables the transcription of genes following external stimulation, like mitogens,
    stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.
    Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)
    but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation
    of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an
    essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK
    isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)
    by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5
    (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early
    anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic
    transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at
    Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity)1
  • Ubiquitinated (By similarity)1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only
    takes place on H3K4me3 and results in gene repression (By similarity)1
  • Ubiquitination2 at Lys57, Lys65, Lys80, Lys123
  • Modification sites at PhosphoSitePlus

  • See HIST3H3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003484.1  
    ENSEMBL proteins: 
     ENSP00000355657  
    Reactome Protein details: Q16695

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    Abcam antibodies for HIST3H3 (P84243, Q16695, Q93081)
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    LSBio Antibodies in human, mouse, rat for HIST3H3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q16695

    ProtoNet protein and cluster: Q16695

    1 Blocks protein domain: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
    Similarity: Belongs to the histone H3 family


    HIST3H3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H31T_HUMAN, Q16695
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17537733
    GO:0046982protein heterodimerization activity IEA--
         
    HIST3H3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST3H3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST3H3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST3H3

    miRNA
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    miRTarBase miRNAs that target HIST3H3:
    hsa-mir-34a-5p (MIRT025216), hsa-mir-1 (MIRT024009)

    Block miRNA regulation of human, mouse, rat HIST3H3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HIST3H3:
    hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H31T_HUMAN, Q16695: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005654nucleoplasm TAS--
    GO:0070062extracellular vesicular exosome IDA--

    HIST3H3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST3H3 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Chromosome Maintenance0.62
    Meiotic Synapsis0.66
    Signal transduction Activin A signaling regulation0.40
    DNA Damage/Telomere Stress Induced Senescence0.65
    Histone modification0.31
    Telomere Maintenance0.64
    2RNA Polymerase I Promoter Opening
    Condensation of Prophase Chromosomes0.78
    Systemic lupus erythematosus0.40
    Mitotic Prophase0.56
    Alcoholism0.34
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50
    5Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST3H3 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    5 GeneGo (Thomson Reuters) Pathways for HIST3H3
        Cell cycle Chromosome condensation in prometaphase
    Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST3H3
        EGFR1 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    FSH signaling pathway

    Selected Reactome Pathways for HIST3H3 (see all 6)
        Packaging Of Telomere Ends
    Meiotic synapsis
    Condensation of Prophase Chromosomes
    Meiotic recombination
    formation of the beta-catenin:TCF transactivating complex


    3 Kegg Pathways  (Kegg details for HIST3H3):
        Alcoholism
    Transcriptional misregulation in cancer
    Systemic lupus erythematosus


    HIST3H3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST3H3
    Interactions:

        Search GeneGlobe Interaction Network for HIST3H3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST3H3 (Q166951, 2, 3 ENSP000003556574) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161041, 2, 3, ENSP000003643104EBI-358900,EBI-494830 MINT-7914854 MINT-7914438 MINT-7914390 MINT-7914502 MINT-7914490 MINT-7914370 MINT-7914453 MINT-7914423 MINT-7914408 MINT-7914478 MINT-7914465 I2D: score=1 STRING: ENSP00000364310
    HIST1H4BP628052, 3, ENSP000003665814MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 STRING: ENSP00000366581
    HIST1H4HP628052, 3, ENSP000002893524MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 STRING: ENSP00000289352
    HIST4H4P628052, 3, ENSP000003507674MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628052, 3MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance TAS--
    GO:0006334nucleosome assembly IEA--

    HIST3H3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST3H3 (H31T)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST3H3 gene: 
    NM_003493.2  

    Unigene Cluster for HIST3H3:

    Histone cluster 3, H3
    Hs.248171  [show with all ESTs]
    Unigene Representative Sequence: DB026731
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366696(uc001hsx.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HIST3H3
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    Additional mRNA sequence: 

    AK312217.1 BC069079.1 BC101837.1 BC101839.1 CR542013.1 

    1 DOTS entry:

    DT.91953314 

    3 AceView cDNA sequences:

    NM_003493 CR542013 BC069079 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST3H3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAAGGACA
    HIST3H3 Expression
    About this image


    HIST3H3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HIST3H3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST3H3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248171

    UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
    Tissue specificity: Expressed in testicular cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HIST3H3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    platypus
    (Ornithorhynchus anatinus)
    Mammalia --
    Histone H3
    92(a)
    1 → many
    Contig819(376811-377242)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H3
    94(a)
    1 → many
    GL343279.1(552493-552912)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004930411 histone H3.2-like 82.84(n)
    96.32(a)
      100493041  XM_002945433.2  XP_002945479.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5707031 histone H3.2-like 81.13(n)
    96.32(a)
      570703  XM_694212.5  XP_699304.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His3:CG338601 His3:CG33860 80.39(n)
    96.32(a)
      3772517  NM_001032207.1  NP_001027378.1 


    ENSEMBL Gene Tree for HIST3H3 (if available)
    TreeFam Gene Tree for HIST3H3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST3H3 gene
    HIST2H3C2  H3F3C2  HIST1H3A2  HIST2H3PS22  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST2H3D2  
    HIST1H3D2  HIST1H3H2  H3F3A2  HIST1H3F2  HIST1H3I2  HIST1H3G2  HIST1H3C2  H3F3B2  
    HIST2H3A2  
    18 SIMAP similar genes for HIST3H3 using alignment to 1 protein entry:     H31T_HUMAN:
    HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F
    HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J    H3F3B    H3F3A
    HIST2H3A    HIST2H3C    HIST2H3D    HIST2H3PS2    H3F3C    CENPA

    HIST3H3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for HIST3H3
    PGOHUM00000242405 PGOHUM00000241030 PGOHUM00000245694 PGOHUM00000251337 PGOHUM00000241478


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST3H3 (see all 133)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812602321,2
    --228612085(+) CTAGCC/TGGACT 1 -- ds50010--------
    rs2019001481,2
    --228612119(+) GCGTG-/TACACAC 1 -- ds50010--------
    rs1439212591,2
    C--228612120(+) CGTGT-/ACACACA 1 -- ds50010--------
    rs1166580511,2
    C,F--228612138(+) CACACG/ACAGGA 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs120840501,2
    C,F,H--228612209(+) CCTAAC/TTGTAG 1 -- ds500110Minor allele frequency- T:0.17NS NA WA 1240
    rs46539571,2
    C,F--228612396(+) GTAACG/ACGTGT 1 -- ds50012Minor allele frequency- A:0.03WA EA 238
    rs46539581,2
    C,F--228612417(+) CCTCCT/CAACTG 1 -- ds50013Minor allele frequency- C:0.03WA NA EA 358
    rs1122832121,2
    C,F--228612436(+) GAACAG/CAGGAT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs11884731,2
    C,F,O,A,H--228612444(+) GATTCG/ACCAGC 1 -- ds500126Minor allele frequency- A:0.14MN NS EA NA WA CSA 2533
    rs794277571,2
    F--228612479(+) AAGCCA/GGCACA 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for HIST3H3 (228612546 - 228613026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HIST3H3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873270CNV Loss21882294
    nsv827019CNV Loss20364138
    nsv508697CNV Loss20534489
    nsv523935CNV Loss19592680
    nsv517545CNV Loss19592680
    nsv873255CNV Loss21882294
    dgv542n71CNV Loss21882294
    esv32853CNV Gain17666407
    nsv826908CNV Gain20364138

    Human Gene Mutation Database (HGMD): HIST3H3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HIST3H3
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST3H3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602820    OMIM disorders: --

    20 diseases for HIST3H3:    
    About MalaCards
    nasopharyngitis    huntington's disease    acute myeloid leukemia    laryngitis
    hiv-1    b-cell lymphomas    tonsillitis    systemic lupus erythematosus
    myeloid leukemia    multiple sclerosis    lupus erythematosus    hypertension
    leukemia    prostatitis    prostate cancer    lung cancer
    colorectal cancer    thyroiditis    cerebritis    endotheliitis


    HIST3H3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST3H3

    Export disorders for HIST3H3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST3H3 gene, integrated from 10 sources (see all 189):
    (articles sorted by number of sources associating them with HIST3H3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. A solitary human H3 histone gene on chromosome 1. (PubMed id 8834248)1, 2, 3 Albig W.... Doenecke D. (Hum. Genet. 1996)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Phosphohistone H3 and Ki-67 labeling indices in cytologic specimens from well-differentiated neuroendocrine tumors of the gastrointestinal tract and pancreas: a comparative analysis using automated image cytometry. (PubMed id 24021213)1 Fung A.D....Reid M.D. (Acta Cytol. 2013)
    6. A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. (PubMed id 24209620)1 Han J.... Zhang Z. (Cell 2013)
    7. Menin mediates epigenetic regulation via histone H3 lysine 9 methylation. (PubMed id 23579270)1 Yang Y.J....Cho E.J. (amp 2013)
    8. Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein. (PubMed id 23161542)1 Cheng J....Xu Y. (J. Biol. Chem. 2013)
    9. H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. (PubMed id 23452851)1 Lauberth S.M....Roeder R.G. (Cell 2013)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8290 HGNC: 4778 AceView: HIST3H3 Ensembl:ENSG00000168148 euGenes: HUgn8290
    ECgene: HIST3H3 Kegg: 8290 H-InvDB: HIST3H3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST3H3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST3H3 gene:
    Search GeneIP for patents involving HIST3H3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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