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Aliases for HIST3H3 Gene

Aliases for HIST3H3 Gene

  • Histone Cluster 3, H3 2 3 5
  • H3 Histone Family, Member T 2 3
  • Histone 3, H3 2 3
  • H3FT 3 4
  • H3/G 3 4
  • H3/T 3 4
  • H3t 3 4
  • H3.4 3

External Ids for HIST3H3 Gene

Previous HGNC Symbols for HIST3H3 Gene

  • H3FT

Previous GeneCards Identifiers for HIST3H3 Gene

  • GC01M224351
  • GC01M224998
  • GC01M225587
  • GC01M224919
  • GC01M226679
  • GC01M228612
  • GC01M199127

Summaries for HIST3H3 Gene

Entrez Gene Summary for HIST3H3 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST3H3 Gene

HIST3H3 (Histone Cluster 3, H3) is a Protein Coding gene. Among its related pathways are Packaging Of Telomere Ends and Cell Cycle Checkpoints. GO annotations related to this gene include protein heterodimerization activity and histone binding. An important paralog of this gene is HIST2H3D.

UniProtKB/Swiss-Prot for HIST3H3 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST3H3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST3H3 Gene

Genomics for HIST3H3 Gene

Regulatory Elements for HIST3H3 Gene

Enhancers for HIST3H3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIST3H3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST3H3 Gene

Chromosome:
1
Start:
228,424,845 bp from pter
End:
228,425,325 bp from pter
Size:
481 bases
Orientation:
Minus strand

Genomic View for HIST3H3 Gene

Genes around HIST3H3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST3H3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST3H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST3H3 Gene

Proteins for HIST3H3 Gene

  • Protein details for HIST3H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16695-H31T_HUMAN
    Recommended name:
    Histone H3.1t
    Protein Accession:
    Q16695
    Secondary Accessions:
    • B2R5K3
    • Q6FGU4

    Protein attributes for HIST3H3 Gene

    Size:
    136 amino acids
    Molecular mass:
    15508 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST3H3 Gene

neXtProt entry for HIST3H3 Gene

Proteomics data for HIST3H3 Gene at MOPED

Post-translational modifications for HIST3H3 Gene

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity).
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity).
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIST3H3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST3H3 Gene

Domains & Families for HIST3H3 Gene

Gene Families for HIST3H3 Gene

Protein Domains for HIST3H3 Gene

Suggested Antigen Peptide Sequences for HIST3H3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16695

UniProtKB/Swiss-Prot:

H31T_HUMAN :
  • Belongs to the histone H3 family.
Family:
  • Belongs to the histone H3 family.
genes like me logo Genes that share domains with HIST3H3: view

Function for HIST3H3 Gene

Molecular function for HIST3H3 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST3H3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST3H3 Gene

Localization for HIST3H3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST3H3 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST3H3 Gene COMPARTMENTS Subcellular localization image for HIST3H3 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST3H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HIST3H3: view

Pathways & Interactions for HIST3H3 Gene

genes like me logo Genes that share pathways with HIST3H3: view

Gene Ontology (GO) - Biological Process for HIST3H3 Gene

None

No data available for SIGNOR curated interactions for HIST3H3 Gene

Drugs & Compounds for HIST3H3 Gene

No Compound Related Data Available

Transcripts for HIST3H3 Gene

mRNA/cDNA for HIST3H3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST3H3 Gene

Histone cluster 3, H3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST3H3 Gene

No ASD Table

Relevant External Links for HIST3H3 Gene

GeneLoc Exon Structure for
HIST3H3
ECgene alternative splicing isoforms for
HIST3H3

Expression for HIST3H3 Gene

mRNA expression in normal human tissues for HIST3H3 Gene

mRNA differential expression in normal tissues according to GTEx for HIST3H3 Gene

This gene is overexpressed in Testis (x26.8).

Protein differential expression in normal tissues from HIPED for HIST3H3 Gene

This gene is overexpressed in Tlymphocyte (14.5), Peripheral blood mononuclear cells (12.0), Nasal epithelium (10.3), Monocytes (8.9), Blymphocyte (7.5), and Neutrophil (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIST3H3 Gene



SOURCE GeneReport for Unigene cluster for HIST3H3 Gene Hs.248171

mRNA Expression by UniProt/SwissProt for HIST3H3 Gene

Q16695-H31T_HUMAN
Tissue specificity: Expressed in testicular cells.
genes like me logo Genes that share expression patterns with HIST3H3: view

Protein tissue co-expression partners for HIST3H3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HIST3H3 Gene

Orthologs for HIST3H3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIST3H3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC518318 35
  • 81.13 (n)
  • 95.59 (a)
-- 36
  • 97 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493041 35
  • 82.84 (n)
  • 96.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570703 35
  • 81.13 (n)
  • 96.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta His3:CG33860 35
  • 80.39 (n)
  • 96.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 90 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
Species with no ortholog for HIST3H3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST3H3 Gene

ENSEMBL:
Gene Tree for HIST3H3 (if available)
TreeFam:
Gene Tree for HIST3H3 (if available)

Paralogs for HIST3H3 Gene

genes like me logo Genes that share paralogs with HIST3H3: view

Variants for HIST3H3 Gene

Sequence variations from dbSNP and Humsavar for HIST3H3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs473316 -- 228,426,422(+) CGGCT(C/T)AGATG upstream-variant-2KB
rs1188473 -- 228,424,743(+) GATTC(A/G)CCAGC downstream-variant-500B
rs1188474 -- 228,425,351(+) CGCGG(C/T)GTCCT upstream-variant-2KB
rs1188475 -- 228,425,770(+) ctgct(C/T)actgc upstream-variant-2KB
rs1188476 -- 228,425,922(+) ggctg(A/G)tctcg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST3H3 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv523935 CNV Loss 19592680
nsv873255 CNV Loss 21882294
nsv827019 CNV Loss 20364138
nsv873270 CNV Loss 21882294
nsv517545 CNV Loss 19592680
dgv542n71 CNV Loss 21882294
nsv508697 CNV Loss 20534489

Variation tolerance for HIST3H3 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST3H3 Gene

Human Gene Mutation Database (HGMD)
HIST3H3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST3H3 Gene

Disorders for HIST3H3 Gene

Relevant External Links for HIST3H3

Genetic Association Database (GAD)
HIST3H3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST3H3

No disorders were found for HIST3H3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST3H3 Gene

Publications for HIST3H3 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. A solitary human H3 histone gene on chromosome 1. (PMID: 8834248) Albig W. … Doenecke D. (Hum. Genet. 1996) 2 3
  3. Brainstem oligodendroglial tumors in children: two case reports and review of literatures. (PMID: 25281433) Fukuoka K. … Nishikawa R. (Childs Nerv Syst 2015) 3
  4. Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. (PMID: 25519907) Qiao Y. … Jing N. (J. Biol. Chem. 2015) 3
  5. The chromodomain-containing histone acetyltransferase TIP60 acts as a code reader, recognizing the epigenetic codes for initiating transcription. (PMID: 25560918) Kim C.H. … Choi K.H. (Biosci. Biotechnol. Biochem. 2015) 3

Products for HIST3H3 Gene

Sources for HIST3H3 Gene

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