Aliases for HIST3H3 Gene
Aliases for HIST3H3 Gene
External Ids for HIST3H3 Gene
- HGNC: 4778
- Entrez Gene: 8290
- Ensembl: ENSG00000168148
- OMIM: 602820
- UniProtKB: Q16695
Previous HGNC Symbols for HIST3H3 Gene
- H3FT
Previous GeneCards Identifiers for HIST3H3 Gene
- GC01M224351
- GC01M224998
- GC01M225587
- GC01M224919
- GC01M226679
- GC01M228612
- GC01M199127
Summaries for HIST3H3 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST3H3 Gene
HIST3H3 (Histone Cluster 3 H3) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Meiosis. GO annotations related to this gene include protein heterodimerization activity and histone binding. An important paralog of this gene is HIST1H3H.
UniProtKB/Swiss-Prot for HIST3H3 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST3H3 Gene
Genomics for HIST3H3 Gene
Regulatory Elements for HIST3H3 Gene
Enhancers for HIST3H3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST3H3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST3H3 Gene
- Chromosome:
- 1
- Start:
- 228,424,845 bp from pter
- End:
- 228,425,325 bp from pter
- Size:
- 481 bases
- Orientation:
- Minus strand
Genomic View for HIST3H3 Gene
Genes around HIST3H3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.13 by Ensembl
- 1q42.13 by Entrez Gene
- 1q42.13 by HGNC
HIST3H3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST3H3 Gene
Proteins for HIST3H3 Gene
-
Protein details for HIST3H3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16695-H31T_HUMAN
- Recommended name:
- Histone H3.1t
- Protein Accession:
- Q16695
- B2R5K3
- Q6FGU4
Protein attributes for HIST3H3 Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15508 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST3H3 Gene
Post-translational modifications for HIST3H3 Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity).
- Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity).
- Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
- Ubiquitinated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HIST3H3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST3H3 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST3H3
-
Custom Antibody ServicesOriGene Antibodies for HIST3H3
- Novus Biologicals Antibodies for HIST3H3
- antibodies-online Antibodies for HIST3H3: See all 80
- GeneTex HIST3H3 antibody for HIST3H3
Protein Products
- EMD Millipore Purified and/or Recombinant HIST3H3 Protein
-
OriGene Purified Proteins for HIST3H3
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- antibodies-online Proteins for HIST3H3: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIST3H3
Assay Products
- EMD Millipore Kits and Assays for HIST3H3
- antibodies-online Kits for HIST3H3: See all 4
-
Abcam assays for HIST3H3
No data available for DME Specific Peptides for HIST3H3 Gene
Domains & Families for HIST3H3 Gene
Gene Families for HIST3H3 Gene
- HGNC:
Protein Domains for HIST3H3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST3H3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16695- Family:
-
- Belongs to the histone H3 family.
Function for HIST3H3 Gene
Molecular function for HIST3H3 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17537733 |
| GO:0042393 | histone binding | IPI | 20498094 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST3H3 Gene
- GenomeRNAi human phenotypes for HIST3H3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST3H3 gene
- Search ViGene Biosciences for HIST3H3
CRISPR Products
-
OriGene CRISPR knockouts for HIST3H3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST3H3
- GenScript: Design CRISPR guide RNA sequences for HIST3H3
miRNA for HIST3H3 Gene
- miRTarBase miRNAs that target HIST3H3
-
- hsa-mir-1-3p (MIRT024009)
- hsa-mir-34a-5p (MIRT025216)
- hsa-mir-760 (MIRT336846)
- hsa-mir-6822-3p (MIRT336850)
- hsa-mir-5572 (MIRT523163)
- hsa-mir-4260 (MIRT523164)
- hsa-mir-450a-2-3p (MIRT523165)
- hsa-mir-6855-5p (MIRT523166)
- hsa-mir-3170 (MIRT523167)
- hsa-mir-6819-5p (MIRT523168)
- hsa-mir-6737-5p (MIRT523169)
- hsa-mir-6812-5p (MIRT523170)
- hsa-mir-8057 (MIRT523171)
- hsa-mir-6748-5p (MIRT523172)
- hsa-mir-6769b-5p (MIRT523173)
- hsa-mir-6769a-5p (MIRT523174)
- hsa-mir-4483 (MIRT523175)
- hsa-mir-1293 (MIRT523176)
- hsa-mir-6766-5p (MIRT523177)
- hsa-mir-6745 (MIRT523178)
- hsa-mir-6756-5p (MIRT523179)
- hsa-mir-363-5p (MIRT523180)
- hsa-mir-6747-5p (MIRT523181)
- hsa-mir-608 (MIRT523182)
- hsa-mir-4651 (MIRT523183)
- hsa-mir-4664-5p (MIRT523184)
- hsa-mir-342-5p (MIRT523185)
- hsa-mir-302a-5p (MIRT523186)
- hsa-mir-1276 (MIRT523187)
miRNA Products
- Search ViGene Biosciences for HIST3H3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST3H3
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HIST3H3
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST3H3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST3H3 gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST3H3 Gene
Localization for HIST3H3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST3H3 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IDA | 25615412 |
| GO:0000788 | nuclear nucleosome | IDA | 20498094 |
| GO:0005634 | nucleus | IEA,IDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HIST3H3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Double-Strand Break Repair |
.53
|
|
| 2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | DNA Double Strand Break Response | ||
Pathways by source for HIST3H3 Gene
1 GeneTex pathway for HIST3H3 Gene
1 BioSystems pathway for HIST3H3 Gene
29 Reactome pathways for HIST3H3 Gene
3 KEGG pathways for HIST3H3 Gene
5 GeneGo (Thomson Reuters) pathways for HIST3H3 Gene
8 Qiagen pathways for HIST3H3 Gene
Interacting Proteins for HIST3H3 Gene
Selected Interacting proteins:
ENSP00000355657
Q16695-H31T_HUMAN
for HIST3H3 Gene via
STRING
UniProtKB
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IMP | 20498094 |
| GO:0016233 | telomere capping | TAS | -- |
| GO:0032460 | negative regulation of protein oligomerization | IMP | 20498094 |
| GO:0051290 | protein heterotetramerization | IDA | 20498094 |
No data available for SIGNOR curated interactions for HIST3H3 Gene
Transcripts for HIST3H3 Gene
mRNA/cDNA for HIST3H3 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST3H3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST3H3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST3H3
- GenScript: Design CRISPR guide RNA sequences for HIST3H3
miRNA Products
- Search ViGene Biosciences for HIST3H3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST3H3
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Clone Products
-
OriGene ORF clones in human for HIST3H3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST3H3 Gene
mRNA differential expression in normal tissues according to GTEx for HIST3H3 Gene
This gene is overexpressed in Testis (x26.8).
This gene is overexpressed in Tlymphocyte (14.5), Peripheral blood mononuclear cells (12.0), Nasal epithelium (10.3), Monocytes (8.9), Blymphocyte (7.5), and Neutrophil (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIST3H3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST3H3 Gene:
HIST3H3SOURCE GeneReport for Unigene cluster for HIST3H3 Gene:
Hs.248171mRNA Expression by UniProt/SwissProt for HIST3H3 Gene:
Q16695-H31T_HUMAN
Tissue specificity:
Expressed in testicular cells.
Evidence on tissue expression from TISSUES for HIST3H3 Gene
- Lung(4.4)
- Adrenal gland(2.1)
- Bone marrow(2.1)
- Heart(2.1)
- Intestine(2.1)
- Kidney(2.1)
- Liver(2.1)
- Lymph node(2.1)
- Muscle(2.1)
- Pancreas(2.1)
- Skin(2.1)
- Spleen(2.1)
- Stomach(2.1)
- Thyroid gland(2.1)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for HIST3H3
-
OriGene qPCR primer pairs for HIST3H3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST3H3 Gene
Orthologs for HIST3H3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
ManyToMany | |
| LOC518318 34 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493041 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC570703 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His3:CG33860 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for HIST3H3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST3H3 Gene
Paralogs for HIST3H3 Gene
(18) SIMAP similar genes for HIST3H3 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HIST3H3 Gene
Variants for HIST3H3 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042512 | -- | 228,425,096(+) | AGTCC(G/T)GAGCG | reference, missense | |
| rs1001475235 | -- | 228,425,492(+) | TATAT(A/T)CATGC | upstream-variant-2KB | |
| rs1001607156 | -- | 228,425,038(+) | TCGCA(C/G)GCCTC | reference, synonymous-codon | |
| rs1003379877 | -- | 228,426,947(+) | CCTCA(C/G)CAGAA | upstream-variant-2KB | |
| rs1003801489 | -- | 228,425,092(+) | TTAAA(-/G)TCCTG | reference, frameshift-variant |
Residual Variation Intolerance Score:
58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.73;
46.73% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST3H3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST3H3 Gene
Disorders for HIST3H3 Gene
Relevant External Links for HIST3H3
No disorders were found for HIST3H3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST3H3 Gene
Publications for HIST3H3 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- A solitary human H3 histone gene on chromosome 1. (PMID: 8834248) Albig W. … Doenecke D. (Hum. Genet. 1996) 2 3 4 64
- Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HIST3H3 Gene
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- Search ViGene Biosciences for HIST3H3
- Search Santa Cruz Biotechnology (SCBT) for HIST3H3 Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST3H3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST3H3
- Horizon Cell Lines for HIST3H3
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST3H3
- VectorBuilder custom plasmid, inducible vectors for HIST3H3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST3H3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST3H3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer