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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST3H3 Gene

protein-coding   GIFtS: 56
GCID: GC01M228612

Histone Cluster 3, H3

(Previous names: H3 histone family, member T, histone 3, H3)
(Previous symbol: H3FT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 3, H31 2     H3/t2 3
H3FT1 2 3 5     H3t2 3
H3 Histone Family, Member T1 2     H3.42
Histone 3, H31 2     Histone H3.1t2
H3/g2 3     H3T5

External Ids:    HGNC: 47781   Entrez Gene: 82902   Ensembl: ENSG000001681487   OMIM: 6028205   UniProtKB: Q166953   

Export aliases for HIST3H3 gene to outside databases

Previous GC identifers: GC01M224351 GC01M224998 GC01M225587 GC01M224919 GC01M226679 GC01M199127


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST3H3 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene
lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from
the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST3H3 Gene: 
HIST3H3 (histone cluster 3, H3) is a protein-coding gene. Diseases associated with HIST3H3 include laryngitis, and huntington's disease, and among its related super-pathways are Signal transduction Activin A signaling regulation and Meiosis. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST2H3D.

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST3H3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST3H3 gene promoter:
         NF-YB   CBF-B   CBF-A   Pax-5   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST3H3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST3H3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST3H3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

HIST3H3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST3H3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228612:  view genomic region     (about GC identifiers)

Start:
228,612,546 bp from pter      End:
228,613,026 bp from pter
Size:
481 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695 (See protein sequence)
Recommended Name: Histone H3.1t  
Size: 136 amino acids; 15508 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down
during the process of differentiation
5 PDB 3D structures from and Proteopedia for HIST3H3:
2V1D (3D)        2YBP (3D)        2YBS (3D)        3A6N (3D)        3T6R (3D)    
Secondary accessions: B2R5K3 Q6FGU4

Explore the universe of human proteins at neXtProt for HIST3H3: NX_Q16695

Explore proteomics data for HIST3H3 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me) (By
    similarity)
  • UniProtKB: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription
    (By similarity)
  • UniProtKB: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at
    Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is
    linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is
    present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while
    it is absent on active promoters (By similarity)
  • UniProtKB: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated
    with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me)
    and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1
    proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3
    and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at
    'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
    Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for
    DNA replication (By similarity)
  • UniProtKB: Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression
    during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important
    during interphase because it enables the transcription of genes following external stimulation, like mitogens,
    stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.
    Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)
    but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation
    of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an
    essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK
    isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)
    by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5
    (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early
    anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic
    transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at
    Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity)
  • UniProtKB: Ubiquitinated (By similarity)
  • UniProtKB: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only
    takes place on H3K4me3 and results in gene repression (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16695

  • HIST3H3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST3H3 Protein Expression
    REFSEQ proteins: NP_003484.1  
    ENSEMBL proteins: 
     ENSP00000355657  
    Reactome Protein details: Q16695
    Human Recombinant Protein Products for HIST3H3: 
    EMD Millipore Purified and/or Recombinant HIST3H3 Protein
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    GenScript Purified and Recombinant Proteins for HIST3H3
    Novus Biologicals HIST3H3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST3H3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005654nucleoplasm TAS--

    HIST3H3 for ontologies           About GeneDecksing



    HIST3H3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST3H3
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    Abcam antibodies for HIST3H3
    Cloud-Clone Corp. Antibodies for HIST3H3 
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    LSBio Antibodies in human, mouse, rat for HIST3H3 

    Assay Products for HIST3H3: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST3H3 
    Cloud-Clone Corp. CLIAs for HIST3H3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q16695

    ProtoNet protein and cluster: Q16695

    1 Blocks protein domain: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
    Similarity: Belongs to the histone H3 family


    HIST3H3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H31T_HUMAN, Q16695
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0005515protein binding IPI17537733
    GO:0046982protein heterodimerization activity IEA--
         
    HIST3H3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST3H3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST3H3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST3H3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST3H3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST3H3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST3H3:
    hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HIST3H3 (NM_003493)
    Sino Biological Human cDNA Clone for HIST3H3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST3H3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST3H3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST3H3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST3H3 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Meiotic Synapsis
    Meiotic Synapsis0.70
    Meiotic Recombination0.62
    Meiosis0.70
    Chromosome Maintenance0.56
    3Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    4Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.56
    Telomere Maintenance0.56
    5UVA-Induced MAPK Signaling
    UVB-Induced MAPK Signaling0.38
    UVA-Induced MAPK Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for HIST3H3 (see all 6)
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Cell cycle Chromosome condensation in prometaphase

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST3H3 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    5 GeneGo (Thomson Reuters) Pathways for HIST3H3
        Cell cycle Chromosome condensation in prometaphase
    Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST3H3
        EGFR1 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    FSH signaling pathway


    5/7        Reactome Pathways for HIST3H3 (see all 7)
        Telomere Maintenance
    Meiotic Synapsis
    Packaging Of Telomere Ends
    Cell Cycle
    Meiosis


    3         Kegg Pathways  (Kegg details for HIST3H3):
        Alcoholism
    Transcriptional misregulation in cancer
    Systemic lupus erythematosus


    HIST3H3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST3H3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/136 Interacting proteins for HIST3H3 (Q166951, 2, 3 ENSP000003556574) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628052, 3, ENSP000003665814MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 STRING: ENSP00000366581
    HIST4H4P628052, 3, ENSP000003507674MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628052, 3MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 
    HIST1H4CP628052, 3MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 
    HIST1H4DP628052, 3MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance TAS--
    GO:0006334nucleosome assembly NAS--

    HIST3H3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST3H3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST3H3 (H31T)

    Search CenterWatch for drugs/clinical trials and news about HIST3H3 / H31T

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST3H3 gene: 
    NM_003493.2  

    Unigene Cluster for HIST3H3:

    Histone cluster 3, H3
    Hs.248171  [show with all ESTs]
    Unigene Representative Sequence: DB026731
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366696(uc001hsx.1)
    miRNA
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    Additional mRNA sequence: 

    AK312217.1 BC069079.1 BC101837.1 BC101839.1 CR542013.1 

    1 DOTS entry:

    DT.91953314 

    3 AceView cDNA sequences:

    NM_003493 CR542013 BC069079 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST3H3 expression in normal human tissues (normalized intensities)      HIST3H3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAAGGACA
    HIST3H3 Expression
    About this image


    HIST3H3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See HIST3H3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST3H3

    SOURCE GeneReport for Unigene cluster: Hs.248171

    UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
    Tissue specificity: Expressed in testicular cells

        SABiosciences Custom PCR Arrays for HIST3H3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HIST3H3 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia HIST2H3A6
    Histone H3
    94(a)
    1 → many
    GL343279.1(552493-552912)
            Species with no ortholog for HIST3H3

    ENSEMBL Gene Tree for HIST3H3 (if available)
    TreeFam Gene Tree for HIST3H3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST3H3 gene
    HIST2H3D2  HIST1H3D2  HIST2H3C2  H3F3C2  HIST1H3H2  HIST1H3A2  H3F3A2  HIST1H3F2  
    HIST1H3G2  HIST1H3I2  HIST1H3B2  HIST1H3C2  HIST1H3J2  H3F3B2  HIST1H3E2  HIST2H3A2  
    18 SIMAP similar genes for HIST3H3 using alignment to 1 protein entry:     H31T_HUMAN:
    HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F
    HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J    H3F3B    H3F3A
    HIST2H3A    HIST2H3C    HIST2H3D    HIST2H3PS2    H3F3C    CENPA

    HIST3H3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for HIST3H3
    PGOHUM00000242405 PGOHUM00000241030 PGOHUM00000245694 PGOHUM00000251337 PGOHUM00000241478


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/133 SNPs in HIST3H3 are shown (see all 133)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812602321,2
    --228612085(+) CTAGCC/TGGACT 1 -- ds50010--------
    rs2019001481,2
    --228612119(+) GCGTG-/TACACAC 1 -- ds50010--------
    rs1439212591,2
    C--228612120(+) CGTGT-/ACACACA 1 -- ds50010--------
    rs1166580511,2
    C,F--228612138(+) CACACG/ACAGGA 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs120840501,2
    C,F,H--228612209(+) CCTAAC/TTGTAG 1 -- ds500110Minor allele frequency- T:0.17NS NA WA 1240
    rs46539571,2
    C,F--228612396(+) GTAACG/ACGTGT 1 -- ds50012Minor allele frequency- A:0.03WA EA 238
    rs46539581,2
    C,F--228612417(+) CCTCCT/CAACTG 1 -- ds50013Minor allele frequency- C:0.03WA NA EA 358
    rs1122832121,2
    C,F--228612436(+) GAACAG/CAGGAT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs11884731,2
    C,F,O,A,H--228612444(+) GATTCG/ACCAGC 1 -- ds500126Minor allele frequency- A:0.14MN NS EA NA WA CSA 2533
    rs794277571,2
    F--228612479(+) AAGCCA/GGCACA 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for HIST3H3 (228612546 - 228613026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HIST3H3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873270CNV Loss21882294
    nsv827019CNV Loss20364138
    nsv508697CNV Loss20534489
    nsv523935CNV Loss19592680
    nsv517545CNV Loss19592680
    nsv873255CNV Loss21882294
    dgv542n71CNV Loss21882294
    esv32853CNV Gain17666407
    nsv826908CNV Gain20364138


    Human Gene Mutation Database (HGMD): HIST3H3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602820    OMIM disorders: --

    14 diseases for HIST3H3:    About MalaCards
    laryngitis    huntington's disease    acute myeloid leukemia    b-cell lymphomas
    systemic lupus erythematosus    multiple sclerosis    myeloid leukemia    lupus erythematosus
    nasopharyngitis    hypertension    prostate cancer    prostatitis
    leukemia    lung cancer


    HIST3H3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST3H3

    Export disorders for HIST3H3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST3H3 gene, integrated from 9 sources (see all 185):
    (articles sorted by number of sources associating them with HIST3H3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. A solitary human H3 histone gene on chromosome 1. (PubMed id 8834248)1, 2, 3 Albig W.... Doenecke D. (1996)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Menin mediates epigenetic regulation via histone H3 ly sine 9 methylation. (PubMed id 23579270)1 Yang Y.J....Cho E.J. (2013)
    6. Structural insight into coordinated recognition of tri methylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tand em tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger d omains, 1) protein. (PubMed id 23161542)1 Cheng J....Xu Y. (2013)
    7. H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. (PubMed id 23452851)1 Lauberth S.M....Roeder R.G. (2013)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    9. Examining post-translational modification-mediated pro tein-protein interactions using a chemical proteomics approach. (PubMed id 23281010)1 Li X....Kapoor T.M. (2013)
    10. Global histone modification of H3K27 correlates with t he outcomes in patients with metachronous liver metastasis of colorectal cancer. (PubMed id 23523318)1 Tamagawa H....Miyagi Y. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8290 HGNC: 4778 AceView: HIST3H3 Ensembl:ENSG00000168148 euGenes: HUgn8290
    ECgene: HIST3H3 Kegg: 8290 H-InvDB: HIST3H3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST3H3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST3H3 gene:
    Search GeneIP for patents involving HIST3H3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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