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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST3H3 Gene

protein-coding   GIFtS: 54
GCID: GC01M228612

histone cluster 3, H3

(Previous names: H3 histone family, member T, histone 3, H3 )
(Previous symbol: H3FT)
 Explore 13 diseases affiliated with
HIST3H3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST3H3    

Aliases
for HIST3H3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 3, H31 2     H3 Histone Family, Member T1 2
H3FT1 2 3 5     Histone 3, H31 2
H3/G1     H3/T1
H3t1 2 3     Histone H3.1t2
H3.41 2     H3T5

External Ids:    HGNC: 47781   Entrez Gene: 82902   Ensembl: ENSG000001681487   OMIM: 6028205   UniProtKB: Q166953   

Export aliases for HIST3H3 gene to outside databases

Previous GC identifers: GC01M224351 GC01M224998 GC01M225587 GC01M224919 GC01M226679 GC01M199127


Summaries
for HIST3H3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST3H3:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of
each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails;
instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that
are in the histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST3H3


Genomic Views
for HIST3H3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST3H3 gene promoter:
         NF-YB   CBF-B   CBF-A   Pax-5   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST3H3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST3H3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST3H3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

HIST3H3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST3H3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228612:  view genomic region     (about GC identifiers)

Start:
 228,612,546 bp from pter      End:
 228,613,026 bp from pter
Size:
 481 bases      Orientation:
 minus strand

Proteins
for HIST3H3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695 (See protein sequence)
Recommended Name: Histone H3.1t  
Size: 136 amino acids; 15508 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down during
the process of differentiation
5 PDB 3D structures from and Proteopedia for HIST3H3:
2V1D (3D)        2YBP (3D)        2YBS (3D)        3A6N (3D)        3T6R (3D)    
Secondary accessions: B2R5K3 Q6FGU4

Explore the universe of human proteins at neXtProt for HIST3H3: NX_Q16695

Post-translational modifications:

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    • (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me) (By
    similarity)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription (By
    • similarity)1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9
    • (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to
    gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the
    3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on
    active promoters (By similarity)1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    • Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA
    double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28
    (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1,
    CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation
    at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at
    Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57
    (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity)1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation
    • at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and
    meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because
    it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV
    irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which
    is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from
    heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell
    transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon
    ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional
    activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at
    Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a
    specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.
    Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity)1
  • Ubiquitinated (By similarity)1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes
    • place on H3K4me3 and results in gene repression (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16695

    • HIST3H3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003484.1  
    ENSEMBL proteins: 
     ENSP00000355657  
    Reactome Protein details: Q16695
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant HIST3H3 Protein
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    Novus Biologicals HIST3H3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST3H3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--


    HIST3H3 for ontologies           About GeneDecksing



    HIST3H3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST3H3
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    Abcam antibodies for HIST3H3 
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    Assay Products for HIST3H3: 
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    Uscn ELISAs and CLIAs for HIST3H3

    Protein Domains /
    Families
    for HIST3H3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST3H3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q16695

    ProtoNet protein and cluster: Q16695

    1 Blocks protein family: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
    Similarity: Belongs to the histone H3 family


    Function
    for HIST3H3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST3H3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST3H3:
    hsa-miR-1276
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HIST3H3

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST3H3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0005515protein binding IPI17567753
    GO:0046982protein heterodimerization activity IEA--


    HIST3H3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST3H3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Packaging Of Telomere Ends0.54
    		Telomere clustering at the nuclear membrane0.82
    		Telomere Maintenance0.38
    		Meiosis0.70
    		Meiotic Recombination0.32
    		Chromosome Maintenance0.56
    2Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    3Formation of Meiotic Holliday Junction
    		Formation of Meiotic Holliday Junction1.00
    		Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    		Formation of Meiotic Heteroduplex0.83
    4Transcription_Sin3 and NuRD in transcription regulation
    		Transcription_Sin3 and NuRD in transcription regulation1.00
    		Transcription Sin3 and NuRD in transcription regulation0.96
    5Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for HIST3H3 (see all 6)
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Cell cycle Chromosome condensation in prometaphase

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST3H3 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    5 GeneGo (Thomson Reuters) Pathways for HIST3H3
        Cell cycle Chromosome condensation in prometaphase
    Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST3H3 
        EGFR1 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    FSH signaling pathway

    5/11        Reactome Pathways for HIST3H3 (see all 11)
        Telomere Maintenance
    Cell Cycle
    Formation of Meiotic Single-stranded DNA Invasion Complex
    Meiotic Recombination
    Telomere clustering at the nuclear membrane


    1         Kegg Pathway  (Kegg details for HIST3H3):
        Systemic lupus erythematosus


    HIST3H3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST3H3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for HIST3H3 (Q166951, 2, 3 ENSP000003556574) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628052, 3, ENSP000003665814MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 STRING: ENSP00000366581
    HIST4H4P628052, 3, ENSP000003507674MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628052, 3MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 
    HIST1H4CP628052, 3MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 
    HIST1H4DP628052, 3MINT-7914854 MINT-4950280 MINT-4950315 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance TAS--
    GO:0006334nucleosome assembly NAS--


    HIST3H3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST3H3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST3H3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST3H3
    Search CenterWatch for drugs/clinical trials and news about HIST3H3 / H31T 

    Transcripts
    for HIST3H3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST3H3 gene: 
    NM_003493.2  

    Unigene Cluster for HIST3H3:

    Histone cluster 3, H3
    Hs.248171  [show with all ESTs]
    Unigene Representative Sequence: DB026731
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366696(uc001hsx.1)

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    hsa-miR-1276
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK312217.1 BC069079.1 BC101837.1 BC101839.1 CR542013.1 

    1 DOTS entry:

    DT.91953314 

    3 AceView cDNA sequences:

    NM_003493 BC069079 CR542013 

    GeneLoc Exon Structure


    Expression
    for HIST3H3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST3H3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTAAGGACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HIST3H3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST3H3

    SOURCE GeneReport for Unigene cluster: Hs.248171

    UniProtKB/Swiss-Prot: H31T_HUMAN, Q16695
    Tissue specificity: Expressed in testicular cells

        SABiosciences Custom PCR Arrays for HIST3H3
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST3H3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST3H3 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NNM8_CHICK6
    		 Uncharacterized protein
    		 93(a)
    		 possible ortholog
    		 3(18255810-18259612)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1735526
    zgc:1735526
    (see all 7)    		 zgc:173552
    (see all 7)    		 96(a)
    96(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 7(76855097-76855507)
    7(76819046-76819456)
    worm
    (Caenorhabditis elegans)    		 Secernentea his-496
    his-276
    (see all 16)    		 Histone H3
    (see all 16)    		 94(a)
    94(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 V(8847921-8848331)
    V(8890016-8890426)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 Core histone H2A/H2B/H3/H4 domain containing prote...
    		 46(a)
    		 1 → many
    		 6(3045566-3048172)


    ENSEMBL Gene Tree for HIST3H3 (if available)
    TreeFam Gene Tree for HIST3H3 (if available) 

    Paralogs
    for HIST3H3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST3H3 gene
    HIST2H3C2  H3F3C2  HIST1H3A2  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST2H3D2  HIST1H3D2  
    HIST1H3H2  H3F3A2  HIST1H3F2  HIST1H3G2  HIST1H3I2  HIST1H3C2  H3F3B2  HIST2H3A2  
    18 SIMAP similar genes for HIST3H3 using alignment to 1 protein entry:     H31T_HUMAN:
    HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F
    HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J    H3F3B    H3F3A
    HIST2H3A    HIST2H3C    HIST2H3D    HIST2H3PS2    H3F3C    CENPA

    HIST3H3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for HIST3H3
    PGOHUM00000242405 PGOHUM00000241030 PGOHUM00000245694 PGOHUM00000251337 PGOHUM00000241478


    Genomic Variants
    for HIST3H3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/97 NCBI SNPs in HIST3H3 are shown (see all 97)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1812602321,2
    		--228612085(+) CTAGCC/TGGACT 1 -- ds50010--------
    rs2019001481,2
    		--228612119(+) GCGTG-/TACACAC 1 -- ds50010--------
    rs1439212591,2
    		C,--228612120(+) CGTGT-/ACACACA 1 -- ds50010--------
    rs1166580511,2
    		F,--228612138(+) CACACG/ACAGGA 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs120840501,2
    		C,F,H,--228612209(+) CCTAAC/TTGTAG 1 -- ds500110Minor allele frequency- T:0.17NS NA WA 1240
    rs46539571,2
    		C,F,--228612396(+) GTAACG/ACGTGT 1 -- ds50012Minor allele frequency- A:0.03WA EA 238
    rs46539581,2
    		C,F,--228612417(+) CCTCCT/CAACTG 1 -- ds50013Minor allele frequency- C:0.03WA NA EA 358
    rs1122832121,2
    		C,--228612436(+) GAACAG/CAGGAT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs11884731,2
    		C,F,O,A,H,--228612444(+) GATTCG/ACCAGC 1 -- ds500126Minor allele frequency- A:0.14MN NS EA NA WA CSA 2533
    rs794277571,2
    		F,--228612479(+) AAGCCA/GGCACA 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for HIST3H3 (228612546 - 228613026 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HIST3H3
         4 CNVs: 48265 6812 48267 48266
    Human Gene Mutation Database (HGMD): HIST3H3

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    Disorders / Diseases
    for HIST3H3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST3H3 for disorders           About GeneDecksing

    OMIM gene information: 602820    OMIM disorders: --

    13 diseases for HIST3H3:    About MalaCards
    b-cell lymphomas    systemic lupus erythematosus    lupus erythematosus    acute myeloid leukemia
    myeloid leukemia    laryngitis    multiple sclerosis    huntington's disease
    laryngeal cancer    leukemia    prostate cancer    prostatitis
    immunodeficiency


    Export disorders for HIST3H3 gene to outside databases

    Publications
    for HIST3H3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST3H3 gene, integrated from 9 sources (see all 157):
    (articles sorted by number of sources associating them with HIST3H3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. A solitary human H3 histone gene on chromosome 1. (PubMed id 8834248)1, 2, 3 Albig W.... Doenecke D. (1996)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Dynamic changes in genomic histone association and mod ification during activation of the ASNS and ATF3 genes by amino acid limitation. (PubMed id 22978410)1 Balasubramanian M.N....Kilberg M.S. (2013)
    6. Tandem PHD fingers of MORF/MOZ acetyltransferases disp lay selectivity for acetylated histone H3 and are required for the association w ith chromatin. (PubMed id 23063713)1 Ali M....Kutateladze T.G. (2012)
    7. Telomere length regulates TERRA levels through increas ed trimethylation of telomeric H3K9 and HP1a. (PubMed id 22922742)1 Arnoult N....Decottignies A. (2012)
    8. PHD finger of the SUMO ligase Siz/PIAS family in rice reveals specific binding for methylated histone H3 at lysine 4 and arginine 2. (PubMed id 22626555)1 Shindo H....Yamazaki T. (2012)
    9. KDM3B is the H3K9 demethylase involved in transcriptio nal activation of lmo2 in leukemia. (PubMed id 22615488)1 Kim J.Y....Seo S.B. (2012)
    10. Global histone modification of histone H3 in colorecta l cancer and its precursor lesions. (PubMed id 21917293)1 Nakazawa T....Katoh R. (2012)

    External Searches for HIST3H3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST3H3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8290 HGNC: 4778 AceView: HIST3H3 Ensembl:ENSG00000168148 euGenes: HUgn8290
    ECgene: HIST3H3 Kegg: 8290 H-InvDB: HIST3H3

    Other Databases showing HIST3H3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST3H3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST3H3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST3H3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST3H3 gene:
    Search GeneIP for patents involving HIST3H3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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