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Aliases for HIST3H2A Gene

Aliases for HIST3H2A Gene

  • Histone Cluster 3, H2a 2 3
  • Histone 3, H2a 2

External Ids for HIST3H2A Gene

Summaries for HIST3H2A Gene

Entrez Gene Summary for HIST3H2A Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST3H2A Gene

HIST3H2A (Histone Cluster 3, H2a) is a Protein Coding gene. Diseases associated with HIST3H2A include hiv-1. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2AM.

UniProtKB/Swiss-Prot for HIST3H2A Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST3H2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST3H2A Gene

Genomics for HIST3H2A Gene

Genomic Location for HIST3H2A Gene

Start:
228,456,979 bp from pter
End:
228,457,873 bp from pter
Size:
895 bases
Orientation:
Minus strand

Genomic View for HIST3H2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST3H2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST3H2A Gene

Regulatory Elements for HIST3H2A Gene

Proteins for HIST3H2A Gene

  • Protein details for HIST3H2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L7L0-H2A3_HUMAN
    Recommended name:
    Histone H2A type 3
    Protein Accession:
    Q7L7L0
    Secondary Accessions:
    • B2R4S4

    Protein attributes for HIST3H2A Gene

    Size:
    130 amino acids
    Molecular mass:
    14121 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for HIST3H2A Gene

Proteomics data for HIST3H2A Gene at MOPED

Post-translational modifications for HIST3H2A Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys16, Lys96, and Lys119

Other Protein References for HIST3H2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST3H2A Gene

Domains for HIST3H2A Gene

Gene Families for HIST3H2A Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST3H2A Gene

Suggested Antigen Peptide Sequences for HIST3H2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L7L0

UniProtKB/Swiss-Prot:

H2A3_HUMAN
Family:
  • Belongs to the histone H2A family.:
    • Q7L7L0
genes like me logo Genes that share domains with HIST3H2A: view

Function for HIST3H2A Gene

Molecular function for HIST3H2A Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST3H2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 22334663
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST3H2A: view

miRNA for HIST3H2A Gene

miRTarBase miRNAs that target HIST3H2A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST3H2A Gene

Localization for HIST3H2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST3H2A Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST3H2A Gene COMPARTMENTS Subcellular localization image for HIST3H2A gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST3H2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome --
GO:0000788 nuclear nucleosome IDA 22334663
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with HIST3H2A: view

Pathways for HIST3H2A Gene

genes like me logo Genes that share pathways with HIST3H2A: view

Pathways by source for HIST3H2A Gene

2 KEGG pathways for HIST3H2A Gene

Gene Ontology (GO) - Biological Process for HIST3H2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006337 nucleosome disassembly IMP 22334663
GO:0070914 UV-damage excision repair IMP 22334663
genes like me logo Genes that share ontologies with HIST3H2A: view

Compounds for HIST3H2A Gene

(1) HMDB Compounds for HIST3H2A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HIST3H2A: view

Transcripts for HIST3H2A Gene

mRNA/cDNA for HIST3H2A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST3H2A Gene

Histone cluster 3, H2a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST3H2A Gene

No ASD Table

Relevant External Links for HIST3H2A Gene

GeneLoc Exon Structure for
HIST3H2A
ECgene alternative splicing isoforms for
HIST3H2A

Expression for HIST3H2A Gene

mRNA expression in normal human tissues for HIST3H2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST3H2A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.8) and Brain - Cerebellum (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HIST3H2A Gene

SOURCE GeneReport for Unigene cluster for HIST3H2A Gene Hs.26331

genes like me logo Genes that share expressions with HIST3H2A: view

No data available for mRNA Expression by UniProt/SwissProt for HIST3H2A Gene

Orthologs for HIST3H2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST3H2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST3H2A 35
  • 99.74 (n)
  • 100 (a)
HIST3H2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIST3H2A 36
  • 98 (a)
OneToOne
LOC614881 35
  • 83.08 (n)
  • 98.46 (a)
dog
(Canis familiaris)
Mammalia HIST3H2A 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist3h2a 35
  • 86.67 (n)
  • 100 (a)
Hist3h2a 16
Hist3h2a 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hist1h2aa 35
  • 84.36 (n)
  • 93.08 (a)
chicken
(Gallus gallus)
Aves H2A-VII 36
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 98 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.8481 35
rice
(Oryza sativa)
Liliopsida Os.12821 35
Species with no ortholog for HIST3H2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST3H2A Gene

ENSEMBL:
Gene Tree for HIST3H2A (if available)
TreeFam:
Gene Tree for HIST3H2A (if available)

Paralogs for HIST3H2A Gene

genes like me logo Genes that share paralogs with HIST3H2A: view

Variants for HIST3H2A Gene

Sequence variations from dbSNP and Humsavar for HIST3H2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs35295147 -- 228,459,208(+) AGCGC(-/T)TGCGC upstream-variant-2KB
rs35550223 -- 228,459,433(+) TCCAT(-/C)CCCTG upstream-variant-2KB
rs41314266 -- 228,459,807(+) AAGCT(C/T)TTTGG upstream-variant-2KB
rs115495640 -- 228,459,661(+) GAAAA(G/T)AATTC upstream-variant-2KB
rs115825350 -- 228,459,103(+) TGATC(C/T)ATCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST3H2A Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv523935 CNV Loss 19592680
nsv873255 CNV Loss 21882294
nsv827019 CNV Loss 20364138
nsv873270 CNV Loss 21882294
nsv517545 CNV Loss 19592680
dgv542n71 CNV Loss 21882294

Relevant External Links for HIST3H2A Gene

HapMap Linkage Disequilibrium report
HIST3H2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST3H2A Gene

Disorders for HIST3H2A Gene

(1) MalaCards Diseases for HIST3H2A Gene

Search for HIST3H2A Gene in MalaCards »
genes like me logo Genes that share disorders with HIST3H2A: view

No data available for UniProtKB/Swiss-Prot for HIST3H2A Gene

Publications for HIST3H2A Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  2. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PMID: 15010469) Zhang Y. … Parvin J.D. (J. Biol. Chem. 2004) 3 4
  3. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PMID: 15078818) Aihara H. … Ito T. (Genes Dev. 2004) 3 4
  4. Role of histone H2A ubiquitination in Polycomb silencing. (PMID: 15386022) Wang H. … Zhang Y. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HIST3H2A Gene

Sources for HIST3H2A Gene

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