Aliases for HIST3H2A Gene
External Ids for HIST3H2A Gene
- HGNC: 20507
- Entrez Gene: 92815
- Ensembl: ENSG00000181218
- OMIM: 615015
- UniProtKB: Q7L7L0
Previous GeneCards Identifiers for HIST3H2A Gene
- GC01M224383
- GC01M225030
- GC01M225619
- GC01M224951
- GC01M226711
- GC01M228645
- GC01M199159
Summaries for HIST3H2A Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST3H2A Gene
HIST3H2A (Histone Cluster 3 H2A) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Deubiquitination. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AC.
UniProtKB/Swiss-Prot for HIST3H2A Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST3H2A Gene
Genomics for HIST3H2A Gene
Regulatory Elements for HIST3H2A Gene
Enhancers for HIST3H2A Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST3H2A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST3H2A Gene
- Chromosome:
- 1
- Start:
- 228,456,979 bp from pter
- End:
- 228,457,873 bp from pter
- Size:
- 895 bases
- Orientation:
- Minus strand
Genomic View for HIST3H2A Gene
Genes around HIST3H2A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.13 by Ensembl
- 1q42.13 by Entrez Gene
- 1q42.13 by HGNC
HIST3H2A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST3H2A Gene
Proteins for HIST3H2A Gene
-
Protein details for HIST3H2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L7L0-H2A3_HUMAN
- Recommended name:
- Histone H2A type 3
- Protein Accession:
- Q7L7L0
- B2R4S4
Protein attributes for HIST3H2A Gene
- Size:
- 130 amino acids
- Molecular mass:
- 14121 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST3H2A Gene
Post-translational modifications for HIST3H2A Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Ubiquitination at posLast=1414 and isoforms=16
- Modification sites at PhosphoSitePlus
Other Protein References for HIST3H2A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Cloud-Clone Corp. Antibodies for HIST3H2A
- Search GeneTex for Antibodies for HIST3H2A
Protein Products
-
OriGene Purified Proteins for HIST3H2A
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- Novus Biologicals lysates for HIST3H2A
- Sino Biological Recombinant Proteins for HIST3H2A
- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for HIST3H2A
- Search GeneTex for Proteins for HIST3H2A
Assay Products
No data available for DME Specific Peptides for HIST3H2A Gene
Domains & Families for HIST3H2A Gene
Gene Families for HIST3H2A Gene
- HGNC:
Protein Domains for HIST3H2A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST3H2A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7L7L0- Family:
-
- Belongs to the histone H2A family.
Function for HIST3H2A Gene
Molecular function for HIST3H2A Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | 22334663 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST3H2A Gene
- GenomeRNAi human phenotypes for HIST3H2A:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Decreased IL-8 secretion
- Increased Nanog expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST3H2A gene
- Search ViGene Biosciences for HIST3H2A
CRISPR Products
-
OriGene CRISPR knockouts for HIST3H2A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST3H2A
- GenScript: Design CRISPR guide RNA sequences for HIST3H2A
miRNA for HIST3H2A Gene
- miRTarBase miRNAs that target HIST3H2A
miRNA Products
- Search ViGene Biosciences for HIST3H2A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST3H2A
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HIST3H2A
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST3H2A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST3H2A gene
- Search ViGene Biosciences for HIST3H2A
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST3H2A Gene
Localization for HIST3H2A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST3H2A Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000788 | nuclear nucleosome | IDA | 22334663 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 23533145 |
Pathways & Interactions for HIST3H2A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
| 2 | Chromatin organization | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Metalloprotease DUBs | ||
Pathways by source for HIST3H2A Gene
11 Reactome pathways for HIST3H2A Gene
2 KEGG pathways for HIST3H2A Gene
Interacting Proteins for HIST3H2A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006337 | nucleosome disassembly | IMP | 22334663 |
| GO:0006342 | chromatin silencing | IBA | -- |
| GO:0070914 | UV-damage excision repair | IMP | 22334663 |
No data available for SIGNOR curated interactions for HIST3H2A Gene
Drugs & Compounds for HIST3H2A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for HIST3H2A Gene
mRNA/cDNA for HIST3H2A Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST3H2A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST3H2A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST3H2A
- GenScript: Design CRISPR guide RNA sequences for HIST3H2A
miRNA Products
- Search ViGene Biosciences for HIST3H2A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST3H2A
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Clone Products
-
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Flow Cytometry Products
Expression for HIST3H2A Gene
mRNA differential expression in normal tissues according to GTEx for HIST3H2A Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.8) and Brain - Cerebellum (x4.8).
This gene is overexpressed in Saliva (40.6) and Heart (18.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIST3H2A Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST3H2A Gene:
HIST3H2ASOURCE GeneReport for Unigene cluster for HIST3H2A Gene:
Hs.26331Evidence on tissue expression from TISSUES for HIST3H2A Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for HIST3H2A
-
OriGene qPCR primer pairs and template standards for HIST3H2A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST3H2A Gene
Orthologs for HIST3H2A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIST3H2A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HIST3H2A 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HIST3H2A 35 |
|
OneToOne | |
| LOC614881 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Hist3h2a 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hist1h2aa 34 |
|
||
| chicken (Gallus gallus) |
Aves | H2A-VII 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| barley (Hordeum vulgare) |
Liliopsida | Hv.8481 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.12821 34 |
|
- Species where no ortholog for HIST3H2A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIST3H2A Gene
Paralogs for HIST3H2A Gene
(26) SIMAP similar genes for HIST3H2A Gene using alignment to 1 proteins:
Variants for HIST3H2A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000238442 | -- | 228,458,768(+) | AGTAA(C/T)GTTGG | downstream-variant-500B, upstream-variant-2KB | |
| rs1001050817 | -- | 228,458,095(+) | CCGAG(C/G)GCCGC | upstream-variant-2KB | |
| rs1002053230 | -- | 228,457,188(+) | TTCCC(-/TGT)TGTTA | downstream-variant-500B, upstream-variant-2KB | |
| rs1002084351 | -- | 228,457,042(+) | TTGAT(G/T)ACCAC | downstream-variant-500B, upstream-variant-2KB | |
| rs1003133451 | -- | 228,457,383(+) | AAGAG(A/C)CTTTA | upstream-variant-2KB, utr-variant-3-prime |
Residual Variation Intolerance Score:
37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.24;
5.31% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST3H2A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST3H2A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST3H2A Gene
Disorders for HIST3H2A Gene
Relevant External Links for HIST3H2A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST3H2A
No disorders were found for HIST3H2A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST3H2A Gene
Publications for HIST3H2A Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PMID: 16702407) Bergink S. … Dantuma N.P. (Genes Dev. 2006) 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PMID: 15823041) Hagiwara T. … Yamada M. (Biochemistry 2005) 3 4 64
- Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PMID: 16359901) Cao R. … Zhang Y. (Mol. Cell 2005) 3 4 64
Products for HIST3H2A Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST3H2A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
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- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
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- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (100) COMPARTMENTS
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