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HIST3H2A Gene

protein-coding   GIFtS: 52
GCID: GC01M228645

Histone Cluster 3, H2a

(Previous names: histone 3, H2a)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 3, H2a1 2
Histone 3, H2a1 2
Histone H2A Type 32

External Ids:    HGNC: 205071   Entrez Gene: 928152   Ensembl: ENSG000001812187   OMIM: 6150155   UniProtKB: Q7L7L03   

Export aliases for HIST3H2A gene to outside databases

Previous GC identifers: GC01M224383 GC01M225030 GC01M225619 GC01M224951 GC01M226711 GC01M199159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST3H2A Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene
contain a palindromic termination element. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST3H2A Gene:
HIST3H2A (histone cluster 3, H2a) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2AD.

UniProtKB/Swiss-Prot: H2A3_HUMAN, Q7L7L0
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST3H2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST3H2A gene promoter:
         Max1   GCNF   Nkx2-5   FAC1   E2F-1   E2F   GCNF-1   FOXO4   NF-Y   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST3H2A promoter sequence
   Search Chromatin IP Primers for HIST3H2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST3H2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

HIST3H2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST3H2A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228645:  view genomic region     (about GC identifiers)

Start:
228,645,065 bp from pter      End:
228,645,560 bp from pter
Size:
496 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: H2A3_HUMAN, Q7L7L0 (See protein sequence)
Recommended Name: Histone H2A type 3  
Size: 130 amino acids; 14121 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Secondary accessions: B2R4S4

Explore the universe of human proteins at neXtProt for HIST3H2A: NX_Q7L7L0

Explore proteomics data for HIST3H2A at MOPED

Post-translational modifications: 

  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly
    represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at
    Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates
    their transcription1
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at
    35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys14, Lys16, Lys96, Lys119
  • Modification sites at PhosphoSitePlus

  • See HIST3H2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_254280.1  
    ENSEMBL proteins: 
     ENSP00000355656  
    Reactome Protein details: Q7L7L0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q7L7L0

    ProtoNet protein and cluster: Q7L7L0

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A3_HUMAN, Q7L7L0
    Similarity: Belongs to the histone H2A family


    Find genes that share domains with HIST3H2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A3_HUMAN, Q7L7L0
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST3H2A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HIST3H2A

    miRNA
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    miRTarBase miRNAs that target HIST3H2A:
    hsa-mir-17-5p (MIRT050829), hsa-mir-93-5p (MIRT048782), hsa-mir-34a-5p (MIRT025540)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2A3_HUMAN, Q7L7L0: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with HIST3H2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST3H2A About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    Chromatin organization0.34
    HATs acetylate histones0.34
    Alcoholism0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with HIST3H2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for HIST3H2A
        HATs acetylate histones


    2 Kegg Pathways  (Kegg details for HIST3H2A):
        Alcoholism
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST3H2A
    Interactions:

        Search GeneGlobe Interaction Network for HIST3H2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST3H2A (Q7L7L02, 3 ENSP000003556564) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCL1AP562792, 3MINT-67415 I2D: score=4 
    DNTTIP2Q5QJE63, ENSP000003521374I2D: score=1 STRING: ENSP00000352137
    KDM2BQ8NHM53, ENSP000003662714I2D: score=1 STRING: ENSP00000366271
    CHD1LQ86WJ13, ENSP000003582624I2D: score=1 STRING: ENSP00000358262
    RPS6KA5O755823, ENSP000002619914I2D: score=1 STRING: ENSP00000261991
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    Find genes that share ontologies with HIST3H2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST3H2A (H2A3)

    1 HMDB Compound for HIST3H2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST3H2A gene: 
    NM_033445.2  

    Unigene Cluster for HIST3H2A:

    Histone cluster 3, H2a
    Hs.26331  [show with all ESTs]
    Unigene Representative Sequence: BM465264
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366695(uc001hsy.3)
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    Additional mRNA sequence: AK311930.1 

    1 DOTS entry:

    DT.450013 

    3 AceView cDNA sequences:

    BE407679 H95999 H95998 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST3H2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGGGCG
    HIST3H2A Expression
    About this image


    HIST3H2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    HIST3H2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST3H2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26331
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST3H2A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist3h2a1 , 5 histone cluster 3, H2a1, 5 86.67(n)1
    100(a)1
      11 (36.38 cM)5
    3191621  NM_178218.31  NP_835736.11 
     589546855 
    chicken
    (Gallus gallus)
    Aves H2A-VII6
    Gallus gallus histone cluster 1, H2A, IX (similar ...
    97(a)
    many ↔ many
    1(47924629-47925018)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H2A
    98(a)
    1 → many
    GL343252.1(1827542-1827931)
    rice
    (Oryza sativa)
    Liliopsida Os.128212 Oryza sativa (japonica cultivar-group) putative histone more 81.58(n)    AK121750.1 


    ENSEMBL Gene Tree for HIST3H2A (if available)
    TreeFam Gene Tree for HIST3H2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST3H2A gene
    HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  HIST1H2AH2  
    HIST1H2AM2  HIST1H2AJ2  HIST1H2AA2  HIST2H2AA42  HIST1H2AE2  HIST1H2AB2  HIST2H2AC2  HIST1H2AK2  
    HIST1H2AL2  H2AFJ2  
    Selected SIMAP similar genes for HIST3H2A using alignment to 1 protein entry:     H2A3_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH
    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST2H2AA3
    HIST2H2AA4    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX

    Find genes that share paralogs with HIST3H2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST3H2A (see all 18)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
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    ----------
    rs1444551231,2
    --228646774(+) GGCCAA/GGATAG 1 -- us2k10--------
    rs1158253501,2
    F--228646804(+) TGATCC/TATCCG 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1483942501,2
    --228646819(+) TGCCTC/TCCAAA 1 -- us2k10--------
    rs1418013221,2
    --228646940(+) AATGAA/GGTTGG 1 -- us2k10--------
    rs1472175591,2
    --228646946(+) GTTGGC/TGTGCG 1 -- us2k10--------
    rs1852310601,2
    --228646980(+) CACCTA/CCCCCC 1 -- us2k10--------
    rs1897666501,2
    C--228646990(+) CAAAAA/GACCCT 1 -- us2k10--------
    rs1405461241,2
    --228647070(+) GAGGCC/TATGGG 1 -- us2k10--------
    rs1444174771,2
    --228647245(+) AAGCAA/CGGCGT 1 -- us2k10--------
    rs1154956401,2
    F--228647362(+) GAAAAG/TAATTC 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for HIST3H2A (228645065 - 228645560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HIST3H2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873270CNV Loss21882294
    nsv827019CNV Loss20364138
    nsv523935CNV Loss19592680
    nsv517545CNV Loss19592680
    nsv873255CNV Loss21882294
    dgv542n71CNV Loss21882294
    esv32853CNV Gain17666407
    nsv826908CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HIST3H2A
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST3H2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615015    OMIM disorders: --


    Find genes that share disorders with HIST3H2A           About GenesLikeMe


    Export disorders for HIST3H2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST3H2A gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with HIST3H2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (Genes Dev. 2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (Biochemistry 2005)
    5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (Mol. Cell 2005)
    6. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (Nature 2004)
    7. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (J. Biol. Chem. 2004)
    8. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (Genes Dev. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. (PubMed id 24352239)2 Tessarz P.... Kouzarides T. (Nature 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92815 HGNC: 20507 AceView: HIST3H2A Ensembl:ENSG00000181218 euGenes: HUgn92815
    ECgene: HIST3H2A Kegg: 92815 H-InvDB: HIST3H2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST3H2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST3H2A gene:
    Search GeneIP for patents involving HIST3H2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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