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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H4B Gene

protein-coding   GIFtS: 51
GCID: GC01M149830

Histone Cluster 2, H4b

(Previous names: histone 2, H4b)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 2, H4b1 2     H4/O3
Histone 2, H4b1 2     H4F23
H4/o2     H4FA3
Histone H42     H4FB3
H4/A3     H4FC3
H4/B3     H4FD3
H4/C3     H4FE3
H4/D3     H4FG3
H4/E3     H4FH3
H4/G3     H4FI3
H4/H3     H4FJ3
H4/I3     H4FK3
H4/J3     H4FM3
H4/K3     H4FN3
H4/M3     H4FO3
H4/N3     HIST2H43

External Ids:    HGNC: 296071   Entrez Gene: 5543132   Ensembl: ENSG000001822177   UniProtKB: P628053   

Export aliases for HIST2H4B gene to outside databases

Previous GC identifers: GC01U901311 GC01M148097 GC01M148092 GC01M148100 GC01M149829 GC01P121186


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST2H4B Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer
composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further
compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher
order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts
from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a
histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this
record represents the telomeric copy. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST2H4B Gene: 
HIST2H4B (histone cluster 2, H4b) is a protein-coding gene. Diseases associated with HIST2H4B include non-hodgkin lymphoma, and hodgkin's lymphoma, and among its related super-pathways are Signal transduction Activin A signaling regulation and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H4B gene promoter:
         TBP   AP-2alpha isoform 3   Pax-2   Pax-2a   Nkx2-5   AP-2alpha isoform 2   Egr-4   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST2H4B promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST2H4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H4B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149830:  view genomic region     (about GC identifiers)

Start:
149,825,607 bp from pter      End:
149,832,725 bp from pter
Size:
7,119 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST2H4B (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST2H4B: NX_P62805

Explore proteomics data for HIST2H4B at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin
  • UniProtKB: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation
  • UniProtKB: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage
  • UniProtKB: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • UniProtKB: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H4
  • UniProtKB: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)
  • UniProtKB: Sumoylated, which is associated with transcriptional repression
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62805

  • HIST2H4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST2H4B Protein Expression
    REFSEQ proteins: NP_001029249.1  
    ENSEMBL proteins: 
     ENSP00000376664   ENSP00000358153   ENSP00000376663  
    Reactome Protein details: P62805
    Human Recombinant Protein Products for HIST2H4B: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST2H4B 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome TAS3035717
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--

    HIST2H4B for ontologies           About GeneDecksing



    HIST2H4B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST2H4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS3035717
    GO:0005515protein binding IPI10220385
    GO:0046982protein heterodimerization activity IEA--
         
    HIST2H4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HIST2H4B:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST2H4B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST2H4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST2H4B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST2H4B 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST2H4B:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST2H4B About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    3Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    4Viral carcinogenesis
    Viral carcinogenesis
    5Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for HIST2H4B
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation


    4 GeneGo (Thomson Reuters) Pathways for HIST2H4B
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST2H4B
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    5/11        Reactome Pathways for HIST2H4B (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST2H4B):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST2H4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/638 Interacting proteins for HIST2H4B (P628051, 2, 3 ENSP000003581534) via UniProtKB, MINT, STRING, and/or I2D (see all 638)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3EP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance TAS--
    GO:0006325chromatin organization NAS15504738
    GO:0006334nucleosome assembly TAS--
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--

    HIST2H4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST2H4B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H4B (H4)

    Search CenterWatch for drugs/clinical trials and news about HIST2H4B / H4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST2H4B gene: 
    NM_001034077.4  

    Unigene Clusters for HIST2H4B:

    Histone cluster 2, H4b
    Hs.55468  [show with all ESTs], Hs.706635
    Unigene Representative Sequences: BQ671323, NM_001034077
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392933 ENST00000369157(uc001esz.1) ENST00000392932(uc001eta.1)

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    Additional mRNA sequence: 

    BC093969.1 BC112193.1 

    13 DOTS entries:

    DT.454682  DT.121432794  DT.97825938  DT.121432862  DT.308787  DT.121432859  DT.92452709  DT.97768687 
    DT.97791265  DT.100709488  DT.121437909  DT.121437914  DT.121437916 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTGGTGT
    HIST2H4B Expression
    About this image


    See HIST2H4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST2H4B

    SOURCE GeneReport for Unigene clusters: Hs.55468 Hs.706635
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIST2H4B gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves H41 germinal histone H4 gene 85.44(n)
    100(a)
      417946  NM_001037845.1  NP_001032934.1 
    lizard
    (Anolis carolinensis)
    Reptilia HIST1H4I6
    HIST1H4I6
    Histone H4
    100(a)
    100(a)
    1 ↔ many
    possible ortholog
    GL343400.1(340525-340836)
    GL343400.1(415743-416054)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1534091 zgc:153409 78.64(n)
    99.03(a)
      767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338771 CG33877-PA 76.7(n)
    98.06(a)
      3772211  NM_001032191.1  NP_001027362.1 
    worm
    (Caenorhabditis elegans)
    Secernentea his-186
    his-106
    (see all 16)
    Histone H4
    (see all 16)
    99(a)
    99(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    V(8898195-8898645)
    II(13823064-13823375)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHF1(YBR009C)4 Histone H4, core histone protein required for chromatin more   --   2(255684-255373) 852294  NP_009563.1 
            Species with no ortholog for HIST2H4B

    ENSEMBL Gene Tree for HIST2H4B (if available)
    TreeFam Gene Tree for HIST2H4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H4B gene
    HIST2H4A1 2  HIST1H4I1 2  HIST1H4K1 2  HIST1H4J1 2  HIST1H4A1 2  HIST1H4L1 2  HIST1H4F1 2  HIST1H4H1 2  
    HIST1H4D1 2  HIST1H4E1 2  HIST1H4B1 2  HIST4H41 2  HIST1H4C1 2  HIST1H4G2  
    3 SIMAP similar genes for HIST2H4B using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4L    HIST1H4H    HIST1H4G

    HIST2H4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in HIST2H4B are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002274421,2
    --149832184(+) GACTT-/AAGTCTT 1 -- ds50010--------
    rs2013579481,2
    --149834448(+) CTGAC-/TCTT  
            
    TAGTA
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST2H4B (149825607 - 149832725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for HIST2H4B (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv469694CNV Loss16826518
    nsv428235CNV Gain18775914
    nsv831525CNV Gain17160897
    nsv872384CNV Gain21882294
    nsv824564CNV Gain20364138
    nsv831503CNV Gain17160897
    esv2750807CNV Gain17911159
    essv23032CNV CNV17122850
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): HIST2H4B
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HIST2H4B
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    8 diseases for HIST2H4B:    About MalaCards
    non-hodgkin lymphoma    hodgkin's lymphoma    retinoblastoma    systemic lupus erythematosus
    lupus erythematosus    hepatocellular carcinoma    leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIST2H4B:
    Cancer

    HIST2H4B for disorders           About GeneDecksing


    Export disorders for HIST2H4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H4B gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with HIST2H4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2, 3 Braastad C.D....Stein G.S. (2004)
    2. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2 Marzluff W.F....Maltais L.J. (2002)
    3. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (1987)
    4. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    5. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    6. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 554313 HGNC: 29607 Ensembl:ENSG00000182217 euGenes: HUgn554313 ECgene: HIST2H4B Kegg: 554313
    H-InvDB: HIST2H4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST2H4B gene:
    Search GeneIP for patents involving HIST2H4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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