Aliases for HIST2H4B Gene
Aliases for HIST2H4B Gene
- Histone Cluster 2 H4 Family Member B 2 3 5
- Histone Cluster 2, H4b 2 3
- Histone 2, H4b 2 3
- H4/O 3 4
- HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
- Histone H4 3
- HIST2H4 4
- H4FA 4
- H4/A 4
- H4/B 4
- H4/C 4
- H4/D 4
- H4/E 4
- H4/G 4
- H4/H 4
- H4/I 4
- H4/J 4
External Ids for HIST2H4B Gene
- HGNC: 29607
- Entrez Gene: 554313
- Ensembl: ENSG00000270276
- UniProtKB: P62805
Previous GeneCards Identifiers for HIST2H4B Gene
- GC01U901311
- GC01M148097
- GC01M148092
- GC01M148100
- GC01M149829
- GC01P121186
- GC01M149830
- GC01M149833
Summaries for HIST2H4B Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST2H4B Gene
HIST2H4B (Histone Cluster 2 H4 Family Member B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4C.
UniProtKB/Swiss-Prot for HIST2H4B Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H4B Gene
Genomics for HIST2H4B Gene
Regulatory Elements for HIST2H4B Gene
Enhancers for HIST2H4B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G149860 | 0.2 | dbSUPER | 0.7 | +0.1 | 108 | 0.3 | HIST2H4B HIST2H3A | |
| GH01G149890 | 0.2 | dbSUPER | 0.7 | +0.4 | 443 | 0.4 | HIST2H4B HIST2H3A | |
| GH01G149892 | 0.2 | dbSUPER | 0.7 | +0.5 | 494 | 0.2 | HIST2H4B HIST2H3A | |
| GH01G149945 | 0.2 | dbSUPER | 0.7 | +1.8 | 1774 | 0.4 | HIST2H4B HIST2H3A | |
| GH01G149957 | 0.2 | dbSUPER | 0.7 | +0.1 | 106 | 0.2 | HIST2H4B HIST2H3A |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST2H4B on UCSC Golden Path with GeneCards custom track
Promoters for HIST2H4B Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00000013439 | 110 | 3001 |
- Transcription factor binding sites by QIAGEN in the HIST2H4B gene promoter:
Regulatory Element Products
Genomic Location for HIST2H4B Gene
- Chromosome:
- 1
- Start:
- 149,854,045 bp from pter
- End:
- 149,861,210 bp from pter
- Size:
- 7,166 bases
- Orientation:
- Minus strand
Genomic View for HIST2H4B Gene
Genes around HIST2H4B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
HIST2H4B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST2H4B Gene
Proteins for HIST2H4B Gene
-
Protein details for HIST2H4B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for HIST2H4B Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
Protein Expression for HIST2H4B Gene
Post-translational modifications for HIST2H4B Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Sumoylated, which is associated with transcriptional repression.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
- Modification sites at PhosphoSitePlus
Other Protein References for HIST2H4B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST2H4B Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST2H4B
- Search GeneTex for Antibodies for HIST2H4B
Protein Products
- EMD Millipore Purified and/or Recombinant HIST2H4B Protein
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIST2H4B
- Origene Custom Protein Services for HIST2H4B
- GeneTex Proteins for HIST2H4B
Assay Products
- EMD Millipore Kits and Assays for HIST2H4B
No data available for DME Specific Peptides for HIST2H4B Gene
Domains & Families for HIST2H4B Gene
Gene Families for HIST2H4B Gene
- HGNC:
Protein Domains for HIST2H4B Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
No data available for Suggested Antigen Peptide Sequences for HIST2H4B Gene
Function for HIST2H4B Gene
Molecular function for HIST2H4B Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,TAS | 3035717 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0042393 | histone binding | IPI | 20498094 |
Phenotypes for HIST2H4B Gene
- GenomeRNAi human phenotypes for HIST2H4B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H4B gene
- Search ViGene Biosciences for HIST2H4B
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H4B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H4B
- GenScript: Design CRISPR guide RNA sequences for HIST2H4B
miRNA for HIST2H4B Gene
- miRTarBase miRNAs that target HIST2H4B
-
- hsa-mir-34a-5p (MIRT025397)
- hsa-mir-98-5p (MIRT027711)
- hsa-mir-26b-5p (MIRT029974)
- hsa-mir-769-3p (MIRT039064)
- hsa-mir-769-5p (MIRT039185)
- hsa-mir-421 (MIRT039367)
- hsa-mir-652-3p (MIRT039537)
- hsa-mir-615-3p (MIRT039608)
- hsa-mir-92b-3p (MIRT040562)
- hsa-mir-505-3p (MIRT041057)
- hsa-mir-484 (MIRT041645)
- hsa-mir-331-3p (MIRT043546)
- hsa-mir-328-3p (MIRT043814)
- hsa-mir-320a (MIRT044598)
- hsa-mir-23b-3p (MIRT046298)
- hsa-mir-222-3p (MIRT046597)
- hsa-mir-204-5p (MIRT047024)
- hsa-mir-181b-5p (MIRT047284)
- hsa-mir-196a-5p (MIRT048158)
- hsa-mir-100-5p (MIRT048555)
- hsa-mir-93-5p (MIRT048828)
- hsa-mir-17-5p (MIRT050863)
- hsa-mir-19a-3p (MIRT367176)
- hsa-mir-19b-3p (MIRT367177)
- hsa-mir-450a-1-3p (MIRT367179)
- hsa-mir-638 (MIRT367182)
- hsa-mir-450b-3p (MIRT367185)
- hsa-mir-887-5p (MIRT367186)
- hsa-mir-3122 (MIRT367189)
- hsa-mir-3913-5p (MIRT367191)
- hsa-mir-4512 (MIRT367194)
- hsa-mir-6513-5p (MIRT367195)
- hsa-mir-18b-3p (MIRT404886)
- hsa-mir-6075 (MIRT404887)
- hsa-mir-5089-5p (MIRT454550)
- hsa-mir-6728-5p (MIRT454551)
- hsa-mir-4713-3p (MIRT454552)
- hsa-mir-6718-5p (MIRT454553)
- hsa-mir-203b-5p (MIRT454554)
miRNA Products
- Search ViGene Biosciences for HIST2H4B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H4B
- Browse OriGene Inhibitory RNA Products For HIST2H4B
- Search ViGene Biosciences for HIST2H4B
Clone Products
-
OriGene ORF clones in human for HIST2H4B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST2H4B
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST2H4B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H4B gene
- Search ViGene Biosciences for HIST2H4B
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H4B Gene
Localization for HIST2H4B Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST2H4B Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IBA | -- |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST2H4B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST2H4B Gene
1 GeneTex pathway for HIST2H4B Gene
1 BioSystems pathway for HIST2H4B Gene
66 Reactome pathways for HIST2H4B Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST2H4B Gene
4 GeneGo (Thomson Reuters) pathways for HIST2H4B Gene
Interacting Proteins for HIST2H4B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
No data available for SIGNOR curated interactions for HIST2H4B Gene
Transcripts for HIST2H4B Gene
mRNA/cDNA for HIST2H4B Gene
- (1) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H4B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H4B
- GenScript: Design CRISPR guide RNA sequences for HIST2H4B
miRNA Products
- Search ViGene Biosciences for HIST2H4B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H4B
- Browse OriGene Inhibitory RNA Products For HIST2H4B
- Search ViGene Biosciences for HIST2H4B
Clone Products
-
OriGene ORF clones in human for HIST2H4B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST2H4B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST2H4B Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST2H4B Gene:
HIST2H4BSOURCE GeneReport for Unigene cluster for HIST2H4B Gene:
Hs.55468Evidence on tissue expression from TISSUES for HIST2H4B Gene
- Liver(4.5)
- Nervous system(4.4)
- Eye(4.2)
- Blood(2.3)
- Lung(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for HIST2H4B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H4B Gene
Orthologs for HIST2H4B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h4a 34 16 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC737496 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100912418 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC525863 34 |
|
||
| chicken (Gallus gallus) |
Aves | HIST1H46L1 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101732103 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:165555 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33869 34 |
|
- Species where no ortholog for HIST2H4B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST2H4B Gene
Paralogs for HIST2H4B Gene
(3) SIMAP similar genes for HIST2H4B Gene using alignment to 1 proteins:
Variants for HIST2H4B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11488173 | -- | 149,862,012(+) | TACTT(C/T)GTAAC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1007634 | OTHER | inversion | 20482838 |
| nsv46 | OTHER | inversion | 15895083 |
| nsv469694 | CNV | loss | 16826518 |
| nsv499132 | OTHER | inversion | 21111241 |
| nsv547843 | CNV | loss | 21841781 |
| nsv7182 | OTHER | inversion | 18451855 |
| nsv824564 | CNV | gain | 20364138 |
| nsv831503 | CNV | gain | 17160897 |
| nsv831525 | CNV | gain | 17160897 |
| nsv946379 | CNV | duplication | 23825009 |
| nsv946381 | CNV | duplication | 23825009 |
Relevant External Links for HIST2H4B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST2H4B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H4B Gene
Disorders for HIST2H4B Gene
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
Relevant External Links for HIST2H4B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST2H4B
No disorders were found for HIST2H4B Gene.
No data available for MalaCards and Genatlas for HIST2H4B Gene
Publications for HIST2H4B Gene
- Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 3 4 64
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 3 4 64
- Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U. … Nick H. (Science 1987) 3 4 64
- Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
- A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants. (PMID: 25362550) Sadakierska-Chudy A. … Filip M. (Neurotox Res 2015) 3 64
Products for HIST2H4B Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore top HIST2H4B Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST2H4B
- EMD Millipore Purified and/or Recombinant HIST2H4B Protein
- EMD Millipore Kits and Assays for HIST2H4B
- EMD Millipore genomic analysis products
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIST2H4B
- Origene Custom Protein Services for HIST2H4B
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST2H4B
- Browse OriGene Inhibitory RNA Products For HIST2H4B
- OriGene qPCR primer pairs for HIST2H4B
- OriGene CRISPR knockouts for HIST2H4B
- OriGene ORF clones in human for HIST2H4B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIST2H4B
- GenScript: Next-day shipping cDNA ORF clone for HIST2H4B in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HIST2H4B
- GenScript Custom Assay Services for HIST2H4B
- GenScript Custom overexpressing Cell Line Services for HIST2H4B
- GenScript: Design CRISPR guide RNA sequences for HIST2H4B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HIST2H4B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for HIST2H4B gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST2H4B gene
- Search ViGene Biosciences for HIST2H4B
- Search Santa Cruz Biotechnology (SCBT) for HIST2H4B Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST2H4B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H4B
- Horizon Cell Lines for HIST2H4B
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST2H4B
- VectorBuilder custom plasmid, inducible vectors for HIST2H4B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST2H4B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST2H4B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer