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Aliases for HIST2H4A Gene

Aliases for HIST2H4A Gene

  • Histone Cluster 2, H4a 2 3
  • H4F2 3 4 6
  • H4FN 3 4 6
  • H4 Histone, Family 2 2 3
  • Histone 2, H4a 2 3
  • HIST2H4 3 4
  • H4/N 3 4
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • H4 Histone Family, Member N 3
  • Histone IV, Family 2 3
  • Histone 2, H4 2
  • Histone H4 3
  • FO108 3
  • H4/G 4
  • H4FG 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/O 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FO 4
  • H4 3

External Ids for HIST2H4A Gene

Previous HGNC Symbols for HIST2H4A Gene

  • H4F2
  • H4FN
  • HIST2H4
  • H4/n

Previous GeneCards Identifiers for HIST2H4A Gene

  • GC01P148070
  • GC01M121215

Summaries for HIST2H4A Gene

Entrez Gene Summary for HIST2H4A Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST2H4A Gene

HIST2H4A (Histone Cluster 2, H4a) is a Protein Coding gene. Among its related pathways are Disease and Apoptotic Pathways in Synovial Fibroblasts.

UniProtKB/Swiss-Prot for HIST2H4A Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H4A Gene

Genomics for HIST2H4A Gene

Regulatory Elements for HIST2H4A Gene

Genomic Location for HIST2H4A Gene

Start:
149,832,657 bp from pter
End:
149,839,767 bp from pter
Size:
7,111 bases
Orientation:
Plus strand

Genomic View for HIST2H4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST2H4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H4A Gene

Proteins for HIST2H4A Gene

  • Protein details for HIST2H4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST2H4A Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST2H4A Gene

neXtProt entry for HIST2H4A Gene

Proteomics data for HIST2H4A Gene at MOPED

Post-translational modifications for HIST2H4A Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H4A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST2H4A Gene

Domains for HIST2H4A Gene

Gene Families for HIST2H4A Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST2H4A Gene

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • P62805
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST2H4A: view

No data available for Suggested Antigen Peptide Sequences for HIST2H4A Gene

Function for HIST2H4A Gene

Molecular function for HIST2H4A Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST2H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 3035717
GO:0005515 protein binding IPI 10220385
GO:0035575 histone demethylase activity (H4-K20 specific) TAS --
GO:0042393 histone binding IPI 20498094
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST2H4A: view

miRNA for HIST2H4A Gene

miRTarBase miRNAs that target HIST2H4A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H4A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST2H4A Gene

Localization for HIST2H4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H4A Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST2H4A Gene COMPARTMENTS Subcellular localization image for HIST2H4A gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 4

Gene Ontology (GO) - Cellular Components for HIST2H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000786 nucleosome TAS 3035717
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 14585971
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST2H4A: view

Pathways for HIST2H4A Gene

genes like me logo Genes that share pathways with HIST2H4A: view

Gene Ontology (GO) - Biological Process for HIST2H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000723 telomere maintenance TAS --
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly TAS --
genes like me logo Genes that share ontologies with HIST2H4A: view

Transcripts for HIST2H4A Gene

mRNA/cDNA for HIST2H4A Gene

Unigene Clusters for HIST2H4A Gene

Histone cluster 2, H4a:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H4A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H4A Gene

No ASD Table

Relevant External Links for HIST2H4A Gene

GeneLoc Exon Structure for
HIST2H4A
ECgene alternative splicing isoforms for
HIST2H4A

Expression for HIST2H4A Gene

mRNA expression in normal human tissues for HIST2H4A Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HIST2H4A Gene

SOURCE GeneReport for Unigene cluster for HIST2H4A Gene Hs.655235

genes like me logo Genes that share expressions with HIST2H4A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST2H4A Gene

Orthologs for HIST2H4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST2H4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia H4 35
  • 83.17 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia LOC486670 35
  • 85.11 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist1h4b 35
  • 86.41 (n)
  • 100 (a)
Hist2h4 16
chimpanzee
(Pan troglodytes)
Mammalia LOC736707 35
  • 84.79 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia LOC100912564 35
  • 83.5 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734147 35
  • 81.88 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884830 35
  • 81.55 (n)
  • 100 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005026 35
  • 82.85 (n)
  • 99.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33905 35
  • 77.02 (n)
  • 99.03 (a)
worm
(Caenorhabditis elegans)
Secernentea his-64 35
  • 77.99 (n)
  • 99.03 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07820 35
  • 77.35 (n)
  • 98.06 (a)
rice
(Oryza sativa)
Liliopsida Os04g0583600 35
  • 82.2 (n)
  • 98.06 (a)
Species with no ortholog for HIST2H4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST2H4A Gene

ENSEMBL:
Gene Tree for HIST2H4A (if available)
TreeFam:
Gene Tree for HIST2H4A (if available)

Paralogs for HIST2H4A Gene

Selected SIMAP similar genes for HIST2H4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST2H4A: view

No data available for Paralogs for HIST2H4A Gene

Variants for HIST2H4A Gene

Sequence variations from dbSNP and Humsavar for HIST2H4A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9436039 -- 149,833,520(+) GCTTA(A/G)AGTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST2H4A Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv872384 CNV Gain 21882294
nsv824564 CNV Gain 20364138
nsv831503 CNV Gain 17160897
nsv469694 CNV Loss 16826518
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
esv1007634 OTHER Inversion 20482838
nsv7182 OTHER Inversion 18451855
nsv499132 OTHER Inversion 21111241
nsv46 OTHER Inversion 15895083

Relevant External Links for HIST2H4A Gene

HapMap Linkage Disequilibrium report
HIST2H4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H4A Gene

Disorders for HIST2H4A Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

(1) University of Copenhagen DISEASES for HIST2H4A Gene

genes like me logo Genes that share disorders with HIST2H4A: view

No data available for MalaCards , OMIM , Novoseek inferred disease relationships , Genatlas and External Links for HIST2H4A Gene

Publications for HIST2H4A Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 3 4
  2. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U. … Nick H. (Science 1987) 2 3 4
  3. Structure and in vitro transcription of a human H4 histone gene. (PMID: 6314274) Sierra F. … Stein J. (Nucleic Acids Res. 1983) 2 3 4
  4. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 3 4
  5. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. (PMID: 12556504) Hovhannisyan H. … Stein J.L. (Mol. Cell. Biol. 2003) 3 23

Products for HIST2H4A Gene

Sources for HIST2H4A Gene

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