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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H4A Gene

protein-coding   GIFtS: 54
GCID: GC01P149804

Histone Cluster 2, H4a

(Previous names: H4 histone, family 2, histone 2, H4, histone 2, H4a)
(Previous symbols: H4F2, H4FN, HIST2H4, H4/n)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 2, H4a1 2     H4/H3
H4F21 2 3 5     H4/I3
H4FN1 2 3 5     H4/J3
HIST2H41 2 3     H4/K3
H4/n1 2     H4/M3
H4 Histone, Family 21 2     H4/N3
Histone 2, H4a1 2     H4/O3
Histone 2, H41     H4FA3
FO1082     H4FB3
H42     H4FC3
H4 Histone Family, Member N2     H4FD3
Histone H42     H4FE3
Histone IV, Family 22     H4FG3
H4/A3     H4FH3
H4/B3     H4FI3
H4/C3     H4FJ3
H4/D3     H4FK3
H4/E3     H4FM3
H4/G3     H4FO3

External Ids:    HGNC: 47941   Entrez Gene: 83702   Ensembl: ENSG000001839417   OMIM: 1427505   UniProtKB: P628053   

Export aliases for HIST2H4A gene to outside databases

Previous GC identifers: GC01P148070 GC01M121215


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST2H4A Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer
composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further
compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher
order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts
from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a
histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this
record represents the centromeric copy. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST2H4A Gene: 
HIST2H4A (histone cluster 2, H4a) is a protein-coding gene. Diseases associated with HIST2H4A include herpes simplex, and non-hodgkin lymphoma, and among its related super-pathways are Signal transduction Activin A signaling regulation and Development NOTCH1-mediated pathway for NF-KB activity modulation. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST2H4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H4A gene promoter:
         AML1a   Tal-1   Pax-2   Pax-2a   Nkx2-5   Tal-1beta   YY1   E47   Egr-4   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIST2H4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H4A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149804:  view genomic region     (about GC identifiers)

Start:
149,804,221 bp from pter      End:
149,811,339 bp from pter
Size:
7,119 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST2H4A (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST2H4A: NX_P62805

Explore proteomics data for HIST2H4A at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin
  • UniProtKB: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation
  • UniProtKB: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage
  • UniProtKB: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • UniProtKB: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H4
  • UniProtKB: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)
  • UniProtKB: Sumoylated, which is associated with transcriptional repression
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62805

  • HIST2H4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST2H4A Protein Expression
    REFSEQ proteins: NP_003539.1  
    ENSEMBL proteins: 
     ENSP00000358162   ENSP00000376669   ENSP00000376668  
    Reactome Protein details: P62805
    Human Recombinant Protein Products for HIST2H4A: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST2H4A 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST2H4A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST2H4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST2H4A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST2H4A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST2H4A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST2H4A About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    3Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    4Viral carcinogenesis
    Viral carcinogenesis
    5Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for HIST2H4A
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation


    4 GeneGo (Thomson Reuters) Pathways for HIST2H4A
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST2H4A
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III


    5/11        Reactome Pathways for HIST2H4A (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST2H4A):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST2H4A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/639 Interacting proteins for HIST2H4A (P628051, 2, 3 ENSP000003581624) via UniProtKB, MINT, STRING, and/or I2D (see all 639)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3EP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3FP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST2H4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST2H4A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H4A (H4)

    Search CenterWatch for drugs/clinical trials and news about HIST2H4A / H4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST2H4A gene: 
    NM_003548.2  

    Unigene Cluster for HIST2H4A:

    Histone cluster 2, H4a
    Hs.655235  [show with all ESTs]
    Unigene Representative Sequence: BX376861
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369165(uc001esu.1) ENST00000392939(uc001est.1) ENST00000392938

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK316561.1 CR542172.1 

    5 DOTS entries:

    DT.454682  DT.121432862  DT.121432794  DT.121432831  DT.95282586 

    24/120 AceView cDNA sequences (see all 120):

    BM973761 AI560456 CK820065 W32074 AW303454 AI361628 BM127447 BE671415 
    BM723543 BQ938866 NM_003548 CA308475 BM980806 AA687915 BM683997 BM055247 
    AI457101 BC019846 AA884241 AW105440 AW469578 AW237123 BQ422840 BF195224 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H4A expression in normal human tissues (normalized intensities)      HIST2H4A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST2H4A Expression
    About this image


    HIST2H4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland ; glandular cells   

    See HIST2H4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST2H4A

    SOURCE GeneReport for Unigene cluster: Hs.655235
        SABiosciences Custom PCR Arrays for HIST2H4A
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H4A gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist2h45 histone cluster 2, H4   --   3 (41.70 cM) 96261682 
    chicken
    (Gallus gallus)
    Aves H41 germinal histone H4 gene 85.44(n)
    100(a)
      417946  NM_001037845.1  NP_001032934.1 
    lizard
    (Anolis carolinensis)
    Reptilia HIST1H4I6
    HIST1H4I6
    Histone H4
    100(a)
    100(a)
    possible ortholog
    possible ortholog
    GL343400.1(415743-416054)
    GL343400.1(340525-340836)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1534091 zgc:153409 78.64(n)
    99.03(a)
      767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338771 CG33877-PA 76.7(n)
    98.06(a)
      3772211  NM_001032191.1  NP_001027362.1 
    worm
    (Caenorhabditis elegans)
    Secernentea his-286
    his-386
    (see all 16)
    Histone H4
    (see all 16)
    99(a)
    99(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    V(8889488-8889799)
    X(7309564-7309889)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHF1(YBR009C)4 Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity less   --   2(255684-255373) 852294  NP_009563.1 
    soybean
    (Glycine max)
    eudicotyledons 444857852   -- 79.87(n)  


    ENSEMBL Gene Tree for HIST2H4A (if available)
    TreeFam Gene Tree for HIST2H4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H4A gene
    HIST2H4B1 2  HIST1H4I1 2  HIST1H4K1 2  HIST1H4J1 2  HIST1H4A1 2  HIST1H4L1 2  HIST1H4F1 2  HIST1H4H1 2  
    HIST1H4D1 2  HIST1H4E1 2  HIST1H4B1 2  HIST4H41 2  HIST1H4C1 2  HIST1H4G2  
    3 SIMAP similar genes for HIST2H4A using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4L    HIST1H4H    HIST1H4G

    HIST2H4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for HIST2H4A (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv469694CNV Loss16826518
    nsv428235CNV Gain18775914
    nsv831525CNV Gain17160897
    nsv872384CNV Gain21882294
    nsv824564CNV Gain20364138
    nsv831503CNV Gain17160897
    esv2750807CNV Gain17911159
    essv23032CNV CNV17122850
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142750    OMIM disorders: --

    9 diseases for HIST2H4A:    About MalaCards
    herpes simplex    non-hodgkin lymphoma    hodgkin's lymphoma    systemic lupus erythematosus
    lupus erythematosus    hepatocellular carcinoma    thyroiditis    leukemia
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIST2H4A:
    Cancer

    HIST2H4A for disorders           About GeneDecksing


    Export disorders for HIST2H4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H4A gene, integrated from 9 sources (see all 110):
    (articles sorted by number of sources associating them with HIST2H4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2, 3 Braastad C.D....Stein G.S. (2004)
    2. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2, 3 Pauli U.... Nick H. (1987)
    3. Structure and in vitro transcription of a human H4 histone gene. (PubMed id 6314274)1, 2, 3 Sierra F.... Stein J. (1983)
    4. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2 Wang Y.... Coonrod S.A. (2004)
    5. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (2003)
    6. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2 Marzluff W.F....Maltais L.J. (2002)
    7. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    8. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. (PubMed id 12556504)1, 9 Hovhannisyan H....Stein J.L. (2003)
    9. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    10. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8370 HGNC: 4794 AceView: HIST2H4.1 Ensembl:ENSG00000183941 euGenes: HUgn8370
    ECgene: HIST2H4A Kegg: 8370 H-InvDB: HIST2H4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST2H4A gene:
    Search GeneIP for patents involving HIST2H4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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