Aliases for HIST2H4A Gene
Aliases for HIST2H4A Gene
- Histone Cluster 2 H4 Family Member A 2 3 5
- Histone Cluster 2, H4a 2 3
- H4 Histone, Family 2 2 3
- Histone 2, H4a 2 3
- HIST2H4 3 4
- H4/N 3 4
- H4F2 3 4
- H4FN 3 4
- HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
- H4 Histone Family, Member N 3
- Histone IV, Family 2 3
- Histone 2, H4 2
- Histone H4 3
- FO108 3
- H4FA 4
- H4/A 4
- H4/B 4
- H4/C 4
- H4/D 4
- H4/E 4
External Ids for HIST2H4A Gene
- HGNC: 4794
- Entrez Gene: 8370
- Ensembl: ENSG00000270882
- OMIM: 142750
- UniProtKB: P62805
Previous HGNC Symbols for HIST2H4A Gene
- H4F2
- H4FN
- HIST2H4
- H4/n
Previous GeneCards Identifiers for HIST2H4A Gene
- GC01P148070
- GC01M121215
Summaries for HIST2H4A Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST2H4A Gene
HIST2H4A (Histone Cluster 2 H4 Family Member A) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4J.
UniProtKB/Swiss-Prot for HIST2H4A Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H4A Gene
Genomics for HIST2H4A Gene
Regulatory Elements for HIST2H4A Gene
Enhancers for HIST2H4A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G149940 | 0.9 | Ensembl dbSUPER | 0.7 | +2.8 | 2844 | 0.6 | BCOR CEBPB ZEB2 CHAMP1 ARID1B NCOR1 SMARCA4 IKZF1 KDM1A | HIST2H4A HIST2H3C |
| GH01G149835 | 0.6 | dbSUPER | 0.7 | +2.5 | 2504 | 0.0 | BCOR CEBPB ZEB2 CHAMP1 ARID1B NCOR1 SMARCA4 IKZF1 KDM1A | HIST2H4A HIST2H3C |
| GH01G149836 | 0.6 | dbSUPER | 0.7 | +2.5 | 2498 | 0.0 | BCOR CEBPB ZEB2 CHAMP1 ARID1B NCOR1 SMARCA4 IKZF1 KDM1A | HIST2H4A HIST2H3C |
| GH01G149834 | 0.6 | dbSUPER | 0.7 | +1.5 | 1510 | 1.9 | BCOR CEBPB ZEB2 CHAMP1 ARID1B NCOR1 SMARCA4 IKZF1 KDM1A | HIST2H4A HIST2H3C |
| GH01G149900 | 0.6 | dbSUPER | 0.7 | +2.5 | 2492 | 0.0 | BCOR CEBPB ZEB2 CHAMP1 ARID1B NCOR1 SMARCA4 IKZF1 KDM1A | HIST2H4A HIST2H3C |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST2H4A on UCSC Golden Path with GeneCards custom track
Promoters for HIST2H4A Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00000013434 | 43 | 3001 |
Regulatory Element Products
Genomic Location for HIST2H4A Gene
- Chromosome:
- 1
- Start:
- 149,832,657 bp from pter
- End:
- 149,839,767 bp from pter
- Size:
- 7,111 bases
- Orientation:
- Plus strand
Genomic View for HIST2H4A Gene
Genes around HIST2H4A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
HIST2H4A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST2H4A Gene
Proteins for HIST2H4A Gene
-
Protein details for HIST2H4A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for HIST2H4A Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
Protein Expression for HIST2H4A Gene
Post-translational modifications for HIST2H4A Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Sumoylated, which is associated with transcriptional repression.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
- Modification sites at PhosphoSitePlus
Other Protein References for HIST2H4A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST2H4A Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST2H4A
- Novus Biologicals Antibodies for HIST2H4A
-
Abcam antibodies for HIST2H4A
- antibodies-online Antibodies for HIST2H4A: See all 1
- GeneTex HIST2H4A antibody for HIST2H4A
Protein Products
- EMD Millipore Purified and/or Recombinant HIST2H4A Protein
-
OriGene Purified Proteins for HIST2H4A
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST2H4A
- Origene Custom Protein Services for HIST2H4A
- Sino Biological Recombinant Proteins for HIST2H4A
- Browse Sino Biological Cell Lysates
- antibodies-online Proteins for HIST2H4A: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIST2H4A
Assay Products
- EMD Millipore Kits and Assays for HIST2H4A
No data available for DME Specific Peptides for HIST2H4A Gene
Domains & Families for HIST2H4A Gene
Gene Families for HIST2H4A Gene
- HGNC:
Protein Domains for HIST2H4A Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
No data available for Suggested Antigen Peptide Sequences for HIST2H4A Gene
Function for HIST2H4A Gene
Molecular function for HIST2H4A Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,TAS | 3035717 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0042393 | histone binding | IPI | 20498094 |
Phenotypes for HIST2H4A Gene
- GenomeRNAi human phenotypes for HIST2H4A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H4A gene
- Search ViGene Biosciences for HIST2H4A
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H4A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H4A
- GenScript: Design CRISPR guide RNA sequences for HIST2H4A
miRNA for HIST2H4A Gene
- miRTarBase miRNAs that target HIST2H4A
-
- hsa-mir-34a-5p (MIRT025235)
- hsa-mir-98-5p (MIRT027408)
- hsa-mir-26b-5p (MIRT028826)
- hsa-mir-19a-3p (MIRT367152)
- hsa-mir-19b-3p (MIRT367153)
- hsa-mir-450a-1-3p (MIRT367156)
- hsa-mir-638 (MIRT367159)
- hsa-mir-769-3p (MIRT367162)
- hsa-mir-450b-3p (MIRT367163)
- hsa-mir-887-5p (MIRT367164)
- hsa-mir-3122 (MIRT367167)
- hsa-mir-3913-5p (MIRT367169)
- hsa-mir-4512 (MIRT367172)
- hsa-mir-6513-5p (MIRT367173)
- hsa-mir-18b-3p (MIRT404884)
- hsa-mir-6075 (MIRT404885)
- hsa-mir-5089-5p (MIRT450972)
- hsa-mir-6728-5p (MIRT450973)
- hsa-mir-4713-3p (MIRT450974)
- hsa-mir-6718-5p (MIRT450975)
- hsa-mir-203b-5p (MIRT450976)
miRNA Products
- Search ViGene Biosciences for HIST2H4A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H4A
- Browse OriGene Inhibitory RNA Products For HIST2H4A
- Search ViGene Biosciences for HIST2H4A
Clone Products
-
OriGene ORF clones in human for HIST2H4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST2H4A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST2H4A
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST2H4A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H4A gene
- Search ViGene Biosciences for HIST2H4A
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H4A Gene
Localization for HIST2H4A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST2H4A Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IBA | -- |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST2H4A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST2H4A Gene
1 GeneTex pathway for HIST2H4A Gene
2 BioSystems pathways for HIST2H4A Gene
66 Reactome pathways for HIST2H4A Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST2H4A Gene
4 GeneGo (Thomson Reuters) pathways for HIST2H4A Gene
2 Qiagen pathways for HIST2H4A Gene
Interacting Proteins for HIST2H4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
No data available for SIGNOR curated interactions for HIST2H4A Gene
Transcripts for HIST2H4A Gene
mRNA/cDNA for HIST2H4A Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (121) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST2H4A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H4A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H4A
- GenScript: Design CRISPR guide RNA sequences for HIST2H4A
miRNA Products
- Search ViGene Biosciences for HIST2H4A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H4A
- Browse OriGene Inhibitory RNA Products For HIST2H4A
- Search ViGene Biosciences for HIST2H4A
Clone Products
-
OriGene ORF clones in human for HIST2H4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST2H4A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST2H4A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST2H4A Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST2H4A Gene:
HIST2H4ASOURCE GeneReport for Unigene cluster for HIST2H4A Gene:
Hs.655235Evidence on tissue expression from TISSUES for HIST2H4A Gene
- Liver(4.5)
- Nervous system(4.4)
- Eye(4.2)
- Blood(2.3)
- Lung(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for HIST2H4A
-
OriGene qPCR primer pairs and template standards for HIST2H4A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H4A Gene
Orthologs for HIST2H4A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h4b 34 16 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC486670 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC736707 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100912564 34 |
|
||
| cow (Bos Taurus) |
Mammalia | H4 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101734147 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101884830 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005026 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33905 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | his-64 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G07820 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0583600 34 |
|
- Species where no ortholog for HIST2H4A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIST2H4A Gene
Paralogs for HIST2H4A Gene
(3) SIMAP similar genes for HIST2H4A Gene using alignment to 1 proteins:
Variants for HIST2H4A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs9436039 | -- | 149,833,520(+) | GCTTA(A/G)AGTTC | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1007634 | OTHER | inversion | 20482838 |
| nsv46 | OTHER | inversion | 15895083 |
| nsv469694 | CNV | loss | 16826518 |
| nsv499132 | OTHER | inversion | 21111241 |
| nsv547843 | CNV | loss | 21841781 |
| nsv7182 | OTHER | inversion | 18451855 |
| nsv824564 | CNV | gain | 20364138 |
| nsv831503 | CNV | gain | 17160897 |
| nsv831525 | CNV | gain | 17160897 |
| nsv946379 | CNV | duplication | 23825009 |
| nsv946381 | CNV | duplication | 23825009 |
Relevant External Links for HIST2H4A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST2H4A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H4A Gene
Disorders for HIST2H4A Gene
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
Relevant External Links for HIST2H4A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST2H4A
No disorders were found for HIST2H4A Gene.
No data available for MalaCards and Genatlas for HIST2H4A Gene
Publications for HIST2H4A Gene
- Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 3 4 64
- Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U. … Nick H. (Science 1987) 2 3 4 64
- Structure and in vitro transcription of a human H4 histone gene. (PMID: 6314274) Sierra F. … Stein J. (Nucleic Acids Res. 1983) 2 3 4 64
- Human PAD4 regulates histone arginine methylation levels via demethylimination. (PMID: 15345777) Wang Y. … Coonrod S.A. (Science 2004) 3 4 64
- Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. (PMID: 12556504) Hovhannisyan H. … Stein J.L. (Mol. Cell. Biol. 2003) 3 22 64
Products for HIST2H4A Gene
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- EMD Millipore top HIST2H4A Antibody
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST2H4A Gene
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