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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H4A Gene

protein-coding   GIFtS: 54
GCID: GC01P149804

histone cluster 2, H4a

(Previous names: H4 histone, family 2, histone 2, H4, histone 2, H4a )
(Previous symbols: H4F2, H4FN, HIST2H4, H4/n)
 Explore 10 diseases affiliated with
HIST2H4A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST2H4A    

Aliases
for HIST2H4A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 2, H4a1 2     H4/H3
H4F21 2 3 5     H4/I3
H4FN1 2 3 5     H4/J3
HIST2H41 2 3     H4/K3
H4/N3     H4/M3
H4 Histone, Family 21 2     H4/N3
Histone 2, H4a1 2     H4/O3
Histone 2, H41     H4FA3
FO1082     H4FB3
H42     H4FC3
H4 Histone Family, Member N2     H4FD3
Histone H42     H4FE3
Histone IV, Family 22     H4FG3
H4/A3     H4FH3
H4/B3     H4FI3
H4/C3     H4FJ3
H4/D3     H4FK3
H4/E3     H4FM3
H4/G3     H4FO3

External Ids:    HGNC: 47941   Entrez Gene: 83702   Ensembl: ENSG000001839417   OMIM: 1427505   UniProtKB: P628053   

Export aliases for HIST2H4A gene to outside databases

Previous GC identifers: GC01P148070 GC01M121215


Summaries
for HIST2H4A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST2H4A:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of
pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails;
instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This
gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H4A


Genomic Views
for HIST2H4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H4A gene promoter:
         AML1a   Tal-1   Pax-2   Pax-2a   Nkx2-5   Tal-1beta   YY1   E47   Egr-4   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIST2H4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H4A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149804:  view genomic region     (about GC identifiers)

Start:
 149,804,221 bp from pter      End:
 149,811,339 bp from pter
Size:
 7,119 bases      Orientation:
 plus strand

Proteins
for HIST2H4A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST2H4A (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST2H4A: NX_P62805

Post-translational modifications:

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the
    • genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation
    • at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4
    (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by
    • SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone
    • chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    • between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone
    H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may
    function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21
    methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62805

    • HIST2H4A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003539.1  
    ENSEMBL proteins: 
     ENSP00000358162   ENSP00000376669   ENSP00000376668  
    Reactome Protein details: P62805
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant HIST2H4A Protein
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    OriGene Protein Over-expression Lysate: HIST2H4A
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    Novus Biologicals HIST2H4A Proteins
    Novus Biologicals HIST2H4A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST2H4A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----


    HIST2H4A for ontologies           About GeneDecksing



    HIST2H4A Antibody Products: 
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    Uscn ELISAs and CLIAs for HIST2H4A

    Protein Domains /
    Families
    for HIST2H4A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST2H4A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    Function
    for HIST2H4A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST2H4A
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST2H4A:
    hsa-miR-18b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----


    HIST2H4A for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST2H4A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    2Transcription_Sin3 and NuRD in transcription regulation
    		Transcription_Sin3 and NuRD in transcription regulation1.00
    		Transcription Sin3 and NuRD in transcription regulation0.96
    3Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    4Development NOTCH1-mediated pathway for NF-KB activity modulation
    		Development NOTCH1-mediated pathway for NF-KB activity modulation1.00
    		Development_NOTCH1-mediated pathway for NF-KB activity modulation0.88
    5Type II interferon signaling (IFNG)
    		Type II interferon signaling (IFNG)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for HIST2H4A
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation


    4 GeneGo (Thomson Reuters) Pathways for HIST2H4A
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    2 BioSystems Pathways for HIST2H4A 
        Type II interferon signaling (IFNG)
    Signaling events mediated by HDAC Class III

    5/17        Reactome Pathways for HIST2H4A (see all 17)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Disease


    1         Kegg Pathway  (Kegg details for HIST2H4A):
        Systemic lupus erythematosus


    HIST2H4A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/606 Interacting proteins for HIST2H4A (P628051, 2, 3 ENSP000003581624) via UniProtKB, MINT, STRING, and/or I2D (see all 606)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3EP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3FP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----
    GO:0045653negative regulation of megakaryocyte differentiation ----


    HIST2H4A for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST2H4A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST2H4A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H4A
    Search CenterWatch for drugs/clinical trials and news about HIST2H4A / H4 

    Transcripts
    for HIST2H4A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST2H4A gene: 
    NM_003548.2  

    Unigene Cluster for HIST2H4A:

    Histone cluster 2, H4a
    Hs.655235  [show with all ESTs]
    Unigene Representative Sequence: BX376861
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369165(uc001esu.1) ENST00000392939(uc001est.1) ENST00000392938


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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK316561.1 BC093969.1 BC112193.1 

    5 DOTS entries:

    DT.454682  DT.121432862  DT.121432794  DT.121432831  DT.95282586 

    24/120 AceView cDNA sequences (see all 120):

    AA515112 BE671415 AW237123 CK820065 BM976874 BM055247 AW105440 AA687915 
    AW469578 BC019846 BM980806 BQ422840 AA884241 AI361628 BE858063 NM_003548 
    W32074 AI123610 BU189753 BQ938866 BM723543 BF195224 AI560456 BE467185 

    GeneLoc Exon Structure


    Expression
    for HIST2H4A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST2H4A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST2H4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST2H4A

    SOURCE GeneReport for Unigene cluster: Hs.655235
        SABiosciences Custom PCR Arrays for HIST2H4A
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST2H4A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H4A gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H41 germinal histone H4 gene 85.44(n)
    100(a)    		   417946  NM_001037845.1  NP_001032934.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HIST1H4D6
    		 --
    		 100(a)
    		 1 ↔ 1
    		 GL343400.1(415743-416054)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1534091 zgc:153409 78.64(n)
    99.03(a)    		   767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta His4:CG338771 CG33877-PA 76.7(n)
    98.06(a)    		   3772211  NM_001032191.1  NP_001027362.1 
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_AER012C1 AER012Cp 83.17(n)
    90.29(a)    		   4621072  NM_210226.1  NP_984872.1 
    soybean
    (Glycine max)    		 eudicotyledons 444857852   -- 79.87(n)  


    ENSEMBL Gene Tree for HIST2H4A (if available)
    TreeFam Gene Tree for HIST2H4A (if available) 

    Paralogs
    for HIST2H4A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H4A gene
    HIST2H4B1 2  HIST1H4I1 2  HIST1H4K1 2  HIST1H4J1 2  HIST1H4A1 2  HIST1H4L1 2  HIST1H4F1 2  HIST1H4H1 2  
    HIST1H4D1 2  HIST1H4E1 2  HIST1H4B1 2  HIST4H41 2  HIST1H4C1 2  HIST1H4G2  
    3 SIMAP similar genes for HIST2H4A using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    HIST2H4A for paralogs           About GeneDecksing



    Genomic Variants
    for HIST2H4A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for HIST2H4A
         6 CNVs: 3313 2326 48130 4255 2052 8329
         3 Inversions: 0391 37081 37080
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    Disorders / Diseases
    for HIST2H4A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST2H4A for disorders           About GeneDecksing

    OMIM gene information: 142750    OMIM disorders: --

    10 diseases for HIST2H4A:    About MalaCards
    non-hodgkin lymphoma    systemic lupus erythematosus    lupus erythematosus    hodgkin's lymphoma
    herpes simplex    hepatocellular carcinoma    immunodeficiency    thyroiditis
    carcinoma    leukemia

    1 disease from the University of Copenhagen DISEASES database for HIST2H4A:
    Cancer

    Export disorders for HIST2H4A gene to outside databases

    Publications
    for HIST2H4A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H4A gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with HIST2H4A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2, 3 Braastad C.D....Stein G.S. (2004)
    2. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2, 3 Pauli U.... Nick H. (1987)
    3. Structure and in vitro transcription of a human H4 histone gene. (PubMed id 6314274)1, 2, 3 Sierra F.... Stein J. (1983)
    4. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2 Wang Y.... Coonrod S.A. (2004)
    5. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (2003)
    6. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2 Marzluff W.F....Maltais L.J. (2002)
    7. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    8. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. (PubMed id 12556504)1, 9 Hovhannisyan H....Stein J.L. (2003)
    9. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)

    External Searches for HIST2H4A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST2H4A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8370 HGNC: 4794 AceView: HIST2H4.1 Ensembl:ENSG00000183941 euGenes: HUgn8370
    ECgene: HIST2H4A Kegg: 8370 H-InvDB: HIST2H4A

    Other Databases showing HIST2H4A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST2H4A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H4A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST2H4A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST2H4A gene:
    Search GeneIP for patents involving HIST2H4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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