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HIST2H4A Gene

protein-coding   GIFtS: 53
GCID: GC01P149804

Histone Cluster 2, H4a

(Previous names: H4 histone, family 2, histone 2, H4, histone 2, H4a)
(Previous symbols: H4F2, H4FN, HIST2H4, H4/n)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 2, H4a1 2     H4/H3
H4F21 2 3 5     H4/I3
H4FN1 2 3 5     H4/J3
HIST2H41 2 3     H4/K3
H4/n1 2     H4/M3
H4 Histone, Family 21 2     H4/N3
Histone 2, H4a1 2     H4/O3
Histone 2, H41     H4FA3
FO1082     H4FB3
H42     H4FC3
H4 Histone Family, Member N2     H4FD3
Histone H42     H4FE3
Histone IV, Family 22     H4FG3
H4/A3     H4FH3
H4/B3     H4FI3
H4/C3     H4FJ3
H4/D3     H4FK3
H4/E3     H4FM3
H4/G3     H4FO3

External Ids:    HGNC: 47941   Entrez Gene: 83702   Ensembl: ENSG000001839417   OMIM: 1427505   UniProtKB: P628053   

Export aliases for HIST2H4A gene to outside databases

Previous GC identifers: GC01P148070 GC01M121215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST2H4A Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer
composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further
compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher
order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts
from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a
histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this
record represents the centromeric copy. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST2H4A Gene:
HIST2H4A (histone cluster 2, H4a) is a protein-coding gene. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST2H4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST2H4A gene promoter:
         AML1a   Tal-1   Pax-2   Pax-2a   Nkx2-5   Tal-1beta   YY1   E47   Egr-4   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HIST2H4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H4A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149804:  view genomic region     (about GC identifiers)

Start:
149,804,221 bp from pter      End:
149,811,339 bp from pter
Size:
7,119 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
Selected PDB 3D structures from and Proteopedia for HIST2H4A (see all 55):
2BQZ (3D)        2CV5 (3D)        2KWN (3D)        2KWO (3D)        2LVM (3D)        2QQS (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST2H4A: NX_P62805

Explore proteomics data for HIST2H4A at MOPED

Post-translational modifications: 

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST2H4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003539.1  
    ENSEMBL proteins: 
     ENSP00000358162   ENSP00000476824   ENSP00000376669   ENSP00000376668  
    Reactome Protein details: P62805

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    Find genes that share domains with HIST2H4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    Find genes that share ontologies with HIST2H4A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HIST2H4A

    miRNA
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    miRTarBase miRNAs that target HIST2H4A:
    hsa-mir-26b-5p (MIRT028826), hsa-mir-98-5p (MIRT027408), hsa-mir-34a-5p (MIRT025235)

    Block miRNA regulation of human, mouse, rat HIST2H4A using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H4_HUMAN, P62805: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    extracellular4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    Find genes that share ontologies with HIST2H4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST2H4A About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50


    Find genes that share SuperPaths with HIST2H4A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST2H4A
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST2H4A
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST2H4A
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III


    Selected Reactome Pathways for HIST2H4A (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST2H4A):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST2H4A
    Interactions:

        Search GeneGlobe Interaction Network for HIST2H4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST2H4A (P628051, 2, 3 ENSP000003581624) via UniProtKB, MINT, STRING, and/or I2D (see all 698)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD2P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000215077P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234507P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234704P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000235307P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-templated transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    Find genes that share ontologies with HIST2H4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for HIST2H4A (H4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST2H4A gene: 
    NM_003548.2  

    Unigene Cluster for HIST2H4A:

    Histone cluster 2, H4a
    Hs.655235  [show with all ESTs]
    Unigene Representative Sequence: BX376861
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369165(uc001esu.1) ENST00000610125 ENST00000392939(uc001est.1)
    ENST00000392938
    miRNA
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    Additional mRNA sequence: 

    AK316561.1 CR542172.1 

    5 DOTS entries:

    DT.454682  DT.121432862  DT.121432794  DT.121432831  DT.95282586 

    Selected AceView cDNA sequences (see all 120):

    BM127447 AI123610 BU189753 AW469578 BM055247 AW105440 CA308475 W32074 
    BM723543 BM980806 AA884241 AI560456 BM973761 AI361628 AW237123 BC019846 
    AI457101 BM683997 CK820065 AW303454 AA515112 BM976874 BF195224 BQ422840 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST2H4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST2H4A Expression
    About this image

    HIST2H4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST2H4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655235
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H4A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist2h45
    Hist1h4b1
    histone cluster 2, H45
    histone cluster 1, H4b1
    86.41(n)1
    100(a)1
      3 (41.70 cM)5
    3266201  NM_178193.11  NP_835500.11 
     962616825 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    100(a)
    1 → many
    GL343400.1(415743-416054)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017341471 histone H4-like 81.88(n)
    100(a)
      101734147  XM_004916996.1  XP_004917053.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018848301 histone H4-like 81.55(n)
    100(a)
      101884830  XM_005168802.1  XP_005168859.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG339051 His4:CG33905 77.02(n)
    99.03(a)
      3771908  NM_001032122.1  NP_001027293.1 
    worm
    (Caenorhabditis elegans)
    Secernentea his-641 his-64 77.99(n)
    99.03(a)
      178066  NM_069753.3  NP_502154.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHF1(YBR009C)4 Histone H4, core histone protein required for chromatin more   --   2(255684-255373) 852294  NP_009563.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G078201 AT1G07820 77.35(n)
    98.06(a)
      837297  NM_100656.5  NP_563797.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05836001 Os04g0583600 82.2(n)
    98.06(a)
      4336777  NM_001060199.1  NP_001053664.1 


    ENSEMBL Gene Tree for HIST2H4A (if available)
    TreeFam Gene Tree for HIST2H4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for HIST2H4A gene
    HIST1H4E2  HIST1H4K2  HIST4H42  HIST1H4F2  HIST1H4L2  HIST2H4B2  HIST1H4I2  HIST1H4B2  
    HIST1H4A2  HIST1H4H2  HIST1H4C2  HIST1H4D2  HIST1H4J2  HIST1H4G2  
    3 SIMAP similar genes for HIST2H4A using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    Find genes that share paralogs with HIST2H4A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HIST2H4A (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469694CNV Loss16826518
    nsv428235CNV Gain18775914
    nsv831525CNV Gain17160897
    nsv872384CNV Gain21882294
    nsv824564CNV Gain20364138
    nsv831503CNV Gain17160897
    esv2750807CNV Gain17911159
    essv23032CNV CNV17122850
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HIST2H4A
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142750    OMIM disorders: --

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell
    NHL). Translocation t(3;6)(q27;p21), with BCL6

  • 1 disease from the University of Copenhagen DISEASES database for HIST2H4A:
    Cancer

    Find genes that share disorders with HIST2H4A           About GenesLikeMe


    Export disorders for HIST2H4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST2H4A gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with HIST2H4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2, 3 Braastad C.D....Stein G.S. (Gene 2004)
    2. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2, 3 Pauli U.... Nick H. (Science 1987)
    3. Structure and in vitro transcription of a human H4 histone gene. (PubMed id 6314274)1, 2, 3 Sierra F.... Stein J. (Nucleic Acids Res. 1983)
    4. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PubMed id 15345777)1, 2 Wang Y.... Coonrod S.A. (Science 2004)
    5. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    7. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (Hum. Genet. 1997)
    8. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. (PubMed id 12556504)1, 9 Hovhannisyan H....Stein J.L. (Mol. Cell. Biol. 2003)
    9. TopBP1 controls BLM protein level to maintain genome stability. (PubMed id 24239288)1 Wang J....Gong Z. (Mol. Cell 2013)
    10. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8370 HGNC: 4794 AceView: HIST2H4.1 Ensembl:ENSG00000183941 euGenes: HUgn8370
    ECgene: HIST2H4A Kegg: 8370 H-InvDB: HIST2H4A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST2H4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HIST2H4A gene:
    Search GeneIP for patents involving HIST2H4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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