Aliases for HIST2H3PS2 Gene
Aliases for HIST2H3PS2 Gene
External Ids for HIST2H3PS2 Gene
- HGNC: 32060
- Entrez Gene: 440686
- Ensembl: ENSG00000203818
Previous GeneCards Identifiers for HIST2H3PS2 Gene
- GC01M147666
- GC01M147671
- GC01M149400
Summaries for HIST2H3PS2 Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a histone pseudogene found on chromosome 1. [provided by RefSeq, Oct 2015]
GeneCards Summary for HIST2H3PS2 Gene
HIST2H3PS2 (Histone Cluster 2 H3 Pseudogene 2) is a Pseudogene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is CENPA.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H3PS2 Gene
Genomics for HIST2H3PS2 Gene
Regulatory Elements for HIST2H3PS2 Gene
Regulatory Element Products
Genomic Location for HIST2H3PS2 Gene
- Chromosome:
- 1
- Start:
- 143,905,510 bp from pter
- End:
- 143,905,966 bp from pter
- Size:
- 457 bases
- Orientation:
- Minus strand
Genomic View for HIST2H3PS2 Gene
Genes around HIST2H3PS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.1 by Ensembl
- 1q21.1 by Entrez Gene
- 1q21.1 by HGNC
HIST2H3PS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST2H3PS2 Gene
Proteins for HIST2H3PS2 Gene
-
Protein details for HIST2H3PS2 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- Q5TEC6
- Recommended name:
- Histone H3
- Protein Accession:
- Q5TEC6
Protein attributes for HIST2H3PS2 Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15430 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST2H3PS2 Gene
Post-translational modifications for HIST2H3PS2 Gene
No Post-translational modifications
Other Protein References for HIST2H3PS2 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for HIST2H3PS2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIST2H3PS2
- Origene Custom Protein Services for HIST2H3PS2
- Novus Biologicals proteins for HIST2H3PS2
- Search GeneTex for Proteins for HIST2H3PS2
-
Abcam proteins for HIST2H3PS2
Assay Products
No data available for DME Specific Peptides for HIST2H3PS2 Gene
Domains & Families for HIST2H3PS2 Gene
Gene Families for HIST2H3PS2 Gene
- HGNC:
Protein Domains for HIST2H3PS2 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HIST2H3PS2 Gene
Function for HIST2H3PS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for HIST2H3PS2
CRISPR Products
- Browse CRISPR knockouts for HIST2H3PS2
miRNA Products
- Search ViGene Biosciences for HIST2H3PS2
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for HIST2H3PS2
- Browse OriGene Inhibitory RNA Products For HIST2H3PS2
- Search ViGene Biosciences for HIST2H3PS2
Clone Products
- GenScript: Custom all cDNA clones Services for HIST2H3PS2
- Sino Biological Human cDNA Clone for HIST2H3PS2
Cell Line Products
- Search ViGene Biosciences for HIST2H3PS2
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIST2H3PS2 Gene
Localization for HIST2H3PS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for HIST2H3PS2 Gene
Transcripts for HIST2H3PS2 Gene
mRNA/cDNA for HIST2H3PS2 Gene
- (1) REFSEQ mRNAs :
- (13) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for HIST2H3PS2
miRNA Products
- Search ViGene Biosciences for HIST2H3PS2
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for HIST2H3PS2
- Browse OriGene Inhibitory RNA Products For HIST2H3PS2
- Search ViGene Biosciences for HIST2H3PS2
Clone Products
- GenScript: Custom all cDNA clones Services for HIST2H3PS2
- Sino Biological Human cDNA Clone for HIST2H3PS2
Flow Cytometry Products
Relevant External Links for HIST2H3PS2 Gene
- GeneLoc Exon Structure for
- HIST2H3PS2
- ECgene alternative splicing isoforms for
- HIST2H3PS2
Expression for HIST2H3PS2 Gene
mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H3PS2 Gene
This gene is overexpressed in CD4 Tcells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for HIST2H3PS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST2H3PS2 Gene:
HIST2H3PS2Primer Products
-
OriGene qPCR primer pairs for HIST2H3PS2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H3PS2 Gene
Orthologs for HIST2H3PS2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
ManyToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Hist2h3c1 35 |
|
OneToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIST2H3PS2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | H3-I 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | HIST2H3PS2 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | hist2h3c 35 |
|
OneToMany | |
| HIST2H3PS2 (1 of 2) 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | His3:CG33833 35 |
|
OneToMany | |
| His3:CG33851 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | his-13 35 |
|
OneToMany | |
| his-17 35 |
|
OneToMany | |||
| his-2 35 |
|
OneToMany | |||
| his-25 35 |
|
OneToMany | |||
| his-27 35 |
|
OneToMany | |||
| his-32 35 |
|
OneToMany | |||
| his-40 35 |
|
OneToMany | |||
| his-42 35 |
|
OneToMany | |||
| his-45 35 |
|
OneToMany | |||
| his-49 35 |
|
OneToMany | |||
| his-55 35 |
|
OneToMany | |||
| his-59 35 |
|
OneToMany | |||
| his-6 35 |
|
OneToMany | |||
| his-63 35 |
|
OneToMany | |||
| his-9 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany |
- Species where no ortholog for HIST2H3PS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for HIST2H3PS2 Gene
- ENSEMBL:
- Gene Tree for HIST2H3PS2 (if available)
- TreeFam:
- Gene Tree for HIST2H3PS2 (if available)
Paralogs for HIST2H3PS2 Gene
(18) SIMAP similar genes for HIST2H3PS2 Gene using alignment to 1 proteins:
Variants for HIST2H3PS2 Gene
Gene Damage Index Score:
2.86;
48.29% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST2H3PS2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST2H3PS2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HIST2H3PS2 Gene
Disorders for HIST2H3PS2 Gene
No disorders were found for HIST2H3PS2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for HIST2H3PS2 Gene
Publications for HIST2H3PS2 Gene
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
- The human histone H3 complement anno 2011. (PMID: 21782046) Ederveen T.H. … Logie C. (Biochim. Biophys. Acta 2011) 3 64
- Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. (PMID: 17189264) Morris S.A. … Strahl B.D. (J. Biol. Chem. 2007) 3 64
Products for HIST2H3PS2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIST2H3PS2
- Origene Custom Protein Services for HIST2H3PS2
- Origene shRNA and RNAi products in human, mouse, rat for HIST2H3PS2
- Browse OriGene Inhibitory RNA Products For HIST2H3PS2
- OriGene qPCR primer pairs for HIST2H3PS2
- Browse CRISPR knockouts for HIST2H3PS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIST2H3PS2
- GenScript: Custom all cDNA clones Services for HIST2H3PS2
- GenScript Custom Purified and Recombinant Proteins Services for HIST2H3PS2
- GenScript Custom Assay Services for HIST2H3PS2
- GenScript Custom overexpressing Cell Line Services for HIST2H3PS2
- Browse GenScript CRISPR for HIST2H3PS2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for HIST2H3PS2
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals proteins for HIST2H3PS2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST2H3PS2
- VectorBuilder custom plasmid, inducible vectors for HIST2H3PS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST2H3PS2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST2H3PS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer