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HIST2H3PS2 Gene

pseudogene   GIFtS: 27
GCID: GC01M149400

Histone Cluster 2, H3, Pseudogene 2

(Previous names: histone 2, H3, pseudogene 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 2, H3, Pseudogene 21 2
Histone 2, H3, Pseudogene 21
p062

External Ids:    HGNC: 320601   Entrez Gene: 4406862   Ensembl: ENSG000002038187   UniProtKB: Q5TEC64   

Export aliases for HIST2H3PS2 gene to outside databases

Previous GC identifers: GC01M147666 GC01M147671


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HIST2H3PS2 Gene:
HIST2H3PS2 (histone cluster 2, H3, pseudogene 2) is a pseudogene. An important paralog of this gene is HIST2H3C.

Gene Wiki entry for HIST2H3PS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for HIST2H3PS2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H3PS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.1

HIST2H3PS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H3PS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149400:  view genomic region     (about GC identifiers)

Start:
149,400,131 bp from pter      End:
149,400,542 bp from pter
Size:
412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: Q5TEC6 (See protein sequence)
Recommended Name: Histone H3  
Size: 136 amino acids; 15430 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity)
1 PDB 3D structure from and Proteopedia for HIST2H3PS2:
4H75 (3D)    

Explore proteomics data for HIST2H3PS2 at MOPED


See HIST2H3PS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000476960  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HIST: Histones / Replication-dependent

3 InterPro protein domains:
 IPR000164 Histone_H3
 IPR009072 Histone-fold
 IPR007125 Histone_core_D

Graphical View of Domain Structure for InterPro Entry Q5TEC6

ProtoNet protein and cluster: Q5TEC6

UniProtKB/TrEMBL: Q5TEC6
Similarity: Belongs to the histone H3 family


Find genes that share domains with HIST2H3PS2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0046982protein heterodimerization activity ----
     
Find genes that share ontologies with HIST2H3PS2           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytoskeleton2
extracellular1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000786nucleosome ----

Find genes that share ontologies with HIST2H3PS2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for HIST2H3PS2

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly ----

Find genes that share ontologies with HIST2H3PS2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for HIST2H3PS2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HIST2H3PS2 gene: 
NM_001025303.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000392948
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1 AceView cDNA sequence:

AW995597 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HIST2H3PS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HIST2H3PS2 Expression
About this image

HIST2H3PS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HIST2H3PS2 Protein Expression
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HIST2H3PS2 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves H3-I6
Histone H3.2
97(a)
many ↔ many
1(48029448-48029858)
lizard
(Anolis carolinensis)
Reptilia HIST2H3PS26
histone cluster 2, H3, pseudogene 2
97(a)
1 ↔ 1
GL343279.1(543895-544305)
zebrafish
(Danio rerio)
Actinopterygii HIST2H3PS2 (1 of 2)6
hist2h3c6
histone cluster 2, H3c
97(a)
97(a)
1 ↔ many
1 ↔ many
25(36123127-36124432) ENSDARG00000068941
25(36169900-36170310) ENSDARG00000097258
fruit fly
(Drosophila melanogaster)
Insecta His3:CG338336
His3:CG338516
His3:CG33851
97(a)
97(a)
1 ↔ many
1 ↔ many
2L(21484681-21485148)
2L(21515062-21515529)
worm
(Caenorhabditis elegans)
Secernentea his-136
his-426
(see all 15)
Protein HIS-42 (his-42) mRNA, complete cds
(see all 15)
95(a)
95(a)
(see all 15)
1 ↔ many
1 ↔ many
(see all 15)
II(13820210-13820620) WBGene00001887
II(13828287-13828697) WBGene00001916
        Species with no ortholog for HIST2H3PS2

ENSEMBL Gene Tree for HIST2H3PS2 (if available)
TreeFam Gene Tree for HIST2H3PS2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HIST2H3PS2 gene
HIST2H3C2  H3F3C2  HIST1H3A2  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST2H3D2  HIST1H3D2  
HIST1H3H2  HIST3H32  H3F3A2  HIST1H3F2  HIST1H3G2  HIST1H3I2  HIST1H3C2  H3F3B2  
HIST2H3A2  
18 SIMAP similar genes for HIST2H3PS2 using alignment to 1 protein entry:     Q5TEC6_HUMAN:
HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F
HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J    HIST2H3A    HIST2H3C
HIST2H3D    HIST3H3    H3F3B    H3F3A    H3F3C    CENPA

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing HIST2H3PS2
DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H3PS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases from the University of Copenhagen DISEASES database for HIST2H3PS2:
Leukemia     Retinoblastoma

Find genes that share disorders with HIST2H3PS2           About GenesLikeMe


Export disorders for HIST2H3PS2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HIST2H3PS2 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with HIST2H3PS2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human histone H3 complement anno 2011. (PubMed id 21782046)1 Ederveen T.H....Logie C. (Biochim. Biophys. Acta 2011)
  2. Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. (PubMed id 17189264)1 Morris S.A.... Strahl B.D. (J. Biol. Chem. 2007)
  3. Organismal differences in post-translational modifications in histones H3 and H4. (PubMed id 17194708)1 Garcia B.A.... Hunt D.F. (J. Biol. Chem. 2007)
  4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1 Kim S.C.... Zhao Y. (Mol. Cell 2006)
  5. Expression patterns and post-translational modifications associated with mammalian histone H3 variants. (PubMed id 16267050)1 Hake S.B.... Hunt D.F. (J. Biol. Chem. 2006)
  6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1 Gregory S.G.... Bentley D.R. (Nature 2006)
  7. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1 Beck H.C.... Jensen O.N. (Mol. Cell. Proteomics 2006)
  8. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PubMed id 16497732)1 Miao F.... Natarajan R. (Mol. Endocrinol. 2006)
  9. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. (PubMed id 16678110)1 Wang H.... Zhang Y. (Mol. Cell 2006)
  10. Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. (PubMed id 15684425)1 Choi H.S.... Dong Z. (J. Biol. Chem. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 440686 HGNC: 32060 AceView: LOC440686.1 Ensembl:ENSG00000203818 euGenes: HUgn440686
ECgene: HIST2H3PS2 H-InvDB: HIST2H3PS2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HIST2H3PS2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HIST2H3PS2 gene:
Search GeneIP for patents involving HIST2H3PS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 Browse ProSpec Recombinant Proteins
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 Browse Antibodies at Cloud-Clone Corp.
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 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for HIST2H3PS2
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H3PS2
 Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST2H3PS2
 Browse SwitchGear Promoter luciferase reporter plasmids for HIST2H3PS2
 Search ThermoFisher Antibodies for HIST2H3PS2
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HIST2H3PS2
 Browse compounds at ApexBio
 Search Addgene for plasmids for HIST2H3PS2
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  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for HIST2H3PS2
  Search antibodies-online for antibodies for HIST2H3PS2
  Search antibodies-online for kits for HIST2H3PS2
  Search antibodies-online for peptides for HIST2H3PS2
 antibodies-online proteins for HIST2H3PS2 (2 products)
       
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