Aliases for HIST2H3D Gene
Aliases for HIST2H3D Gene
External Ids for HIST2H3D Gene
- HGNC: 25311
- Entrez Gene: 653604
- Ensembl: ENSG00000183598
- UniProtKB: Q71DI3
Previous GeneCards Identifiers for HIST2H3D Gene
- GC01M148051
- GC01M149784
Summaries for HIST2H3D Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST2H3D Gene
HIST2H3D (Histone Cluster 2 H3 Family Member D) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Meiosis. GO annotations related to this gene include protein heterodimerization activity and histone binding. An important paralog of this gene is HIST2H3A.
UniProtKB/Swiss-Prot for HIST2H3D Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H3D Gene
Genomics for HIST2H3D Gene
Regulatory Elements for HIST2H3D Gene
Enhancers for HIST2H3D Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G149826 | 0.2 | Ensembl | 0.4 | -12.9 | -12921 | 0.4 | GC01M149831 HIST2H3D |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST2H3D on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST2H3D Gene
- Chromosome:
- 1
- Start:
- 149,813,225 bp from pter
- End:
- 149,813,681 bp from pter
- Size:
- 457 bases
- Orientation:
- Minus strand
Genomic View for HIST2H3D Gene
Genes around HIST2H3D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
HIST2H3D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST2H3D Gene
Proteins for HIST2H3D Gene
-
Protein details for HIST2H3D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q71DI3-H32_HUMAN
- Recommended name:
- Histone H3.2
- Protein Accession:
- Q71DI3
- A2BDF6
- A6NFS4
- Q6B053
Protein attributes for HIST2H3D Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15388 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer.
Protein Expression for HIST2H3D Gene
Post-translational modifications for HIST2H3D Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (PubMed:22483618).
- Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
- Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
- Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- Ubiquitination at posLast=116116
- Modification sites at PhosphoSitePlus
Other Protein References for HIST2H3D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST2H3D
-
Cloud-Clone Corp. Antibodies for HIST2H3D
- Search GeneTex for Antibodies for HIST2H3D
Protein Products
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-
Cloud-Clone Corp. Proteins for HIST2H3D
- Search GeneTex for Proteins for HIST2H3D
Assay Products
-
Cloud-Clone Corp Assay Kits for HIST2H3D
No data available for DME Specific Peptides for HIST2H3D Gene
Domains & Families for HIST2H3D Gene
Gene Families for HIST2H3D Gene
- HGNC:
Protein Domains for HIST2H3D Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST2H3D Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q71DI3- Family:
-
- Belongs to the histone H3 family.
Function for HIST2H3D Gene
Molecular function for HIST2H3D Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 20580717 |
| GO:0042393 | histone binding | IPI | 25615412 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST2H3D Gene
- GenomeRNAi human phenotypes for HIST2H3D:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H3D gene
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CRISPR Products
-
OriGene CRISPR knockouts for HIST2H3D
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H3D
- GenScript: Design CRISPR guide RNA sequences for HIST2H3D
miRNA for HIST2H3D Gene
- miRTarBase miRNAs that target HIST2H3D
-
- hsa-mir-1-3p (MIRT023947)
- hsa-mir-34a-5p (MIRT025503)
- hsa-mir-221-3p (MIRT046861)
- hsa-mir-760 (MIRT333010)
- hsa-mir-6822-3p (MIRT333018)
- hsa-mir-1245b-5p (MIRT511572)
- hsa-mir-8061 (MIRT511573)
- hsa-mir-4760-5p (MIRT511574)
- hsa-mir-8057 (MIRT511575)
- hsa-mir-369-5p (MIRT511576)
- hsa-mir-4766-5p (MIRT511577)
- hsa-mir-146a-3p (MIRT511578)
- hsa-mir-1276 (MIRT511579)
miRNA Products
- Search ViGene Biosciences for HIST2H3D
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H3D
- Browse OriGene Inhibitory RNA Products For HIST2H3D
- Search ViGene Biosciences for HIST2H3D
Clone Products
-
OriGene ORF clones in human for HIST2H3D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
Horizon Cell Lines for HIST2H3D
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST2H3D gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H3D gene
- Search ViGene Biosciences for HIST2H3D
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H3D Gene
Localization for HIST2H3D Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST2H3D Gene
- Nucleus. Chromosome.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0000786 | nucleosome | IDA | 21636898 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IDA,IEA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from COMPARTMENTS for HIST2H3D Gene
Pathways & Interactions for HIST2H3D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | Cellular Senescence | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Chromatin organization | ||
| 5 | Mitotic Prophase |
.57
|
|
Pathways by source for HIST2H3D Gene
1 BioSystems pathway for HIST2H3D Gene
54 Reactome pathways for HIST2H3D Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST2H3D Gene
Interacting Proteins for HIST2H3D Gene
Selected Interacting proteins:
Q71DI3-H32_HUMAN
ENSP00000333277
for HIST2H3D Gene via
MINT
UniProtKB
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006325 | chromatin organization | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA | 21636898 |
| GO:0007596 | blood coagulation | TAS | -- |
No data available for SIGNOR curated interactions for HIST2H3D Gene
Transcripts for HIST2H3D Gene
mRNA/cDNA for HIST2H3D Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST2H3D Gene
- Histone cluster 2, H3d:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H3D
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H3D
- GenScript: Design CRISPR guide RNA sequences for HIST2H3D
miRNA Products
- Search ViGene Biosciences for HIST2H3D
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H3D
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Clone Products
-
OriGene ORF clones in human for HIST2H3D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for HIST2H3D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HIST2H3D Gene
This gene is overexpressed in Whole Blood (x5.5).
This gene is overexpressed in Heart (35.7) and Urine (21.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST2H3D Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIST2H3D Gene:
HIST2H3DSOURCE GeneReport for Unigene cluster for HIST2H3D Gene:
Hs.712062Primer Products
-
OriGene qPCR primer pairs for HIST2H3D
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H3D Gene
Orthologs for HIST2H3D Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h3f 35 |
|
ManyToMany | |
| Hist1h3c 34 16 |
|
||||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
ManyToMany | |
| LOC531990 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | LOC746430 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIST2H3D 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC684762 34 |
|
||
| chicken (Gallus gallus) |
Aves | LOC770022 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495338 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | HIST2H3D 35 |
|
OneToOne | |
| LOC564732 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | His3:CG31613 35 |
|
OneToOne | |
| His3:CG33851 34 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CSE4 37 |
|
|
- Species where no ortholog for HIST2H3D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST2H3D Gene
Paralogs for HIST2H3D Gene
(16) SIMAP similar genes for HIST2H3D Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HIST2H3D Gene
Variants for HIST2H3D Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs113528548 | -- | 149,813,557(+) | GCCGG(C/T)AGCGG | upstream-variant-2KB, reference, missense | |
| rs11438815 | -- | 149,814,526(+) | TTTTT(-/A/T)CTGTT | upstream-variant-2KB | |
| rs115659429 | -- | 149,815,078(+) | AAATA(G/T)ATGTT | upstream-variant-2KB | |
| rs11590455 | -- | 149,814,925(+) | TCGAG(A/C/G)GATCT | upstream-variant-2KB | |
| rs116310582 | -- | 149,813,700(+) | TAGGA(A/G)AGGGT | upstream-variant-2KB |
Residual Variation Intolerance Score:
68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.24;
5.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST2H3D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST2H3D
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H3D Gene
Disorders for HIST2H3D Gene
Relevant External Links for HIST2H3D
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST2H3D
No disorders were found for HIST2H3D Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H3D Gene
Publications for HIST2H3D Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 3 4 64
- Serine ADP-ribosylation depends on HPF1. (PMID: 28190768) Bonfiglio J.J. … Matic I. (Mol. Cell 2017) 4 64
- Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. (PMID: 25416818) Tang M. … Songyang Z. (J. Cell. Sci. 2015) 3 64
- Human tNASP promotes in vitro nucleosome assembly with histone H3.3. (PMID: 25615412) Kato D. … Kurumizaka H. (Biochemistry 2015) 3 64
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
Products for HIST2H3D Gene
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST2H3D Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer