Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H3C Gene

protein-coding   GIFtS: 50
GCID: GC01M149812

histone cluster 2, H3c

(Previous names: H3 histone family, member M, histone 2, H3c )
(Previous symbols: H3F2, H3FM)
 Explore 21 diseases affiliated with
HIST2H3C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST2H3C    

Aliases
for HIST2H3C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 2, H3c1 2     Histone H3/M2 3
H3F21 2 3 5     H3/M1 2
H3FM1 2 3     MGC96291
H31 2     H3FN2
H3.21 2     H3 Histone, Family 22
H3/M1 2     Histone H3.22
H3 Histone Family, Member M1 2     Histone H3/O3
Histone 2, H3c1 2     

External Ids:    HGNC: 205031   Entrez Gene: 1269612   Ensembl: ENSG000002038117   OMIM: 1427805   UniProtKB: Q71DI33   

Export aliases for HIST2H3C gene to outside databases

Previous GC identifers: GC01M145553 GC01M146586 GC01M147028 GC01M147001 GC01M146598 GC01U901205 GC01M148078 GC01P121206


Summaries
for HIST2H3C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST2H3C:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of
pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails;
instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This
gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H3C


Genomic Views
for HIST2H3C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H3C gene promoter:
         AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   E47   Egr-4   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST2H3C promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST2H3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H3C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149812:  view genomic region     (about GC identifiers)

Start:
 149,811,110 bp from pter      End:
 149,812,765 bp from pter
Size:
 1,656 bases      Orientation:
 minus strand

Proteins
for HIST2H3C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3 (See protein sequence)
Recommended Name: Histone H3.2  
Size: 136 amino acids; 15388 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome
assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down during
the process of differentiation
6/9 PDB 3D structures from and Proteopedia for HIST2H3C (see all 9):
2IIJ (3D)        2X4W (3D)        2X4X (3D)        2X4Y (3D)        3AV1 (3D)        3DB3 (3D)    
Secondary accessions: A2BDF6 A6NFS4 Q6B053

Explore the universe of human proteins at neXtProt for HIST2H3C: NX_Q71DI3

Post-translational modifications:

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    • (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9
    • (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to
    gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the
    3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on
    active promoters1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    • Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA
    double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28
    (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1,
    CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation
    at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at
    Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57
    (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation
    • at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and
    meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because
    it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV
    irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which
    is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from
    heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell
    transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon
    ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional
    activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at
    Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a
    specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.
    Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin1
  • Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
    • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes
    • place on H3K4me3 and results in gene repression (PubMed:22483618)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q71DI3

    • HIST2H3C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066403.2  
    ENSEMBL proteins: 
     ENSP00000358154  
    Reactome Protein details: Q71DI3
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HIST2H3C
    OriGene Custom Protein Services for HIST2H3C 
    GenScript Custom Purified and Recombinant Proteins Services for HIST2H3C
    Novus Biologicals HIST2H3C Proteins
    Novus Biologicals HIST2H3C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST2H3C

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----


    HIST2H3C for ontologies           About GeneDecksing



    HIST2H3C Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST2H3C
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST2H3C 
    GenScript Custom Superior Antibodies Services for HIST2H3C
    Novus Biologicals HIST2H3C Antibodies
    Search for Antibodies for HIST2H3C at Abcam  
    Uscn Antibodies for HIST2H3C
    ThermoFisher Antibodies for HIST2H3C

    Assay Products for HIST2H3C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST2H3C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST2H3C

    Protein Domains /
    Families
    for HIST2H3C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST2H3C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q71DI3

    ProtoNet protein and cluster: Q71DI3

    1 Blocks protein family: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3
    Similarity: Belongs to the histone H3 family


    Function
    for HIST2H3C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HIST2H3C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST2H3C
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST2H3C:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST2H3C (see all 4)
    OriGene shRNA RFP: HIST2H3C
    OriGene siRNA: HIST2H3C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST2H3C

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIST2H3C

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H3C (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H3C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIST2H3C (NM_021059)
    Sino Biological Human cDNA Clone for HIST2H3C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST2H3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H3C 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HIST2H3C
    Search LifeMap BioReagents cell lines for HIST2H3C

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST2H3C

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----


    HIST2H3C for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST2H3C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiosis0.70
    		Meiotic Recombination0.32
    2Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    3IL-4 signaling Pathway
    		IL-4 signaling Pathway1.00
    4Systemic lupus erythematosus
    		Systemic lupus erythematosus1.00
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for HIST2H3C 
        IL-4 signaling Pathway

    5/6        Reactome Pathways for HIST2H3C (see all 6)
        Amyloids
    Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Meiosis
    Meiotic Recombination


    1         Kegg Pathway  (Kegg details for HIST2H3C):
        Systemic lupus erythematosus


    HIST2H3C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/136 Interacting proteins for HIST2H3C (Q71DI31, 2, 3 ENSP000003581544) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----
    GO:0007596blood coagulation ----


    HIST2H3C for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST2H3C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIST2H3C for compounds           About GeneDecksing

    EMD Millipore small molecules for HIST2H3C:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H3C
    10/14 Novoseek chemical compound relationships for HIST2H3C gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 57.7 8 14763127 (1), 15231737 (1), 19828451 (1), 8155651 (1) (see all 7)
    5-aza-2'deoxycytidine 44.7 1 15805278 (1)
    okadaic acid 29 3 11709551 (1), 9811564 (1)
    adpribose 28.7 1 1736995 (1)
    butyrate 24.7 1 15225415 (1)
    biotin 24.1 1 11606205 (1)
    arginine 20.3 3 16426232 (1), 18338885 (1), 8155651 (1)
    protamine 15.1 2 1736995 (1), 8234025 (1)
    atp 0 2 1945884 (1), 10402647 (1)
    nickel 0 2 16283522 (1), 12729258 (1)

    Search CenterWatch for drugs/clinical trials and news about HIST2H3C / H32 

    Transcripts
    for HIST2H3C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST2H3C gene: 
    NM_021059.2  

    Unigene Cluster for HIST2H3C:

    Histone cluster 2, H3c
    Hs.647745  [show with all ESTs]
    Unigene Representative Sequence: BG389013
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369158(uc001esv.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HIST2H3C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST2H3C
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST2H3C:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST2H3C (see all 4)
    OriGene shRNA RFP: HIST2H3C
    OriGene siRNA: HIST2H3C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST2H3C
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H3C (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H3C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIST2H3C (NM_021059)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST2H3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H3C 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST2H3C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIST2H3C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST2H3C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST2H3C

    Additional cDNA sequence: 

    BC130635.1 BC130637.1 

    3 DOTS entries:

    DT.92452709  DT.121432808  DT.121432859 

    GeneLoc Exon Structure


    Expression
    for HIST2H3C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HIST2H3C Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.647745
        SABiosciences Custom PCR Arrays for HIST2H3C
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST2H3C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIST2H3C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST2H3C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST2H3C
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST2H3C

    Orthologs
    for HIST2H3C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H3C gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008586811 histone H3.2-like 92.16(n)
    100(a)    		   100858681  XM_003640374.1  XP_003640422.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HIST3H36
    HIST2H3C6
    (see all 4)    		 --
    		 97(a)
    100(a)
    (see all 4)    		 possible ortholog
    1 ↔ 1
    (see all 4)    		 GL343279.1(552493-552912)
    GL343400.1(348673-349083)
    zebrafish
    (Danio rerio)    		 Actinopterygii hist2h3ca11 histone 2, H3ca1 83.09(n)
    99.26(a)    		   368227  XM_002662732.1  XP_002662778.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta His3:CG338336
    His3:CG338666
    (see all 5)    		 His3:CG33866
    (see all 5)    		 100(a)
    100(a)
    (see all 5)    		 possible ortholog
    possible ortholog
    (see all 5)    		 2L(21484681-21485148)
    2L(21541153-21541620)
    worm
    (Caenorhabditis elegans)    		 Secernentea his-321 Protein HIS-32 78.43(n)
    97.06(a)    		   177628  NM_069006.2  NP_501407.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G133701 histone H3 70.59(n)
    91.18(a)    		   837897  NM_101207.2  NP_172794.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    		 Core histone H2A/H2B/H3/H4 domain containing prote...
    		 48(a)
    		 1 → many
    		 6(3045566-3048172)


    ENSEMBL Gene Tree for HIST2H3C (if available)
    TreeFam Gene Tree for HIST2H3C (if available) 

    Paralogs
    for HIST2H3C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H3C gene
    HIST2H3A1 2  HIST2H3D1 2  H3F3C2  HIST1H3A2  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST1H3D2  
    HIST1H3H2  HIST3H32  H3F3A2  HIST1H3F2  HIST1H3I2  HIST1H3G2  HIST1H3C2  H3F3B2  
    16 SIMAP similar genes for HIST2H3C using alignment to 1 protein entry:     H32_HUMAN:
    H3F3B    H3F3A    HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D
    HIST1H3E    HIST1H3F    HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J
    HIST2H3PS2    HIST3H3    H3F3C    CENPA

    HIST2H3C for paralogs           About GeneDecksing



    Genomic Variants
    for HIST2H3C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for HIST2H3C
         6 CNVs: 3313 2326 48130 4255 2052 8329
         3 Inversions: 0391 37081 37080
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST2H3C
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H3C

    Disorders / Diseases
    for HIST2H3C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST2H3C for disorders           About GeneDecksing

    OMIM gene information: 142780    OMIM disorders: --

    20/21 diseases for HIST2H3C (see all 21):    About MalaCards
    prader-willi syndrome    oral squamous cell carcinoma    systemic lupus erythematosus    squamous cell carcinoma
    lupus erythematosus    leukoplakia    ptosis    gout
    vaccinia    endometrial cancer    liver cancer    pancreatic carcinoma
    colon cancer    arthritis    carcinoma    immunodeficiency
    astrocytoma    pancreatitis    leukemia    mental retardation syndrome

    7 Novoseek disease relationships for HIST2H3C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arthritis juvenile rheumatoid 14.6 1 2261004 (1)
    autoimmunity 7.62 1 18375534 (1)
    cancer 3.48 1 14763127 (1)
    carcinoma squamous cell 0 2 16476033 (2)
    autoimmune diseases 0 1 16222244 (1)
    tumors 0 5 11812781 (1), 15158912 (1), 19187765 (1)
    immunodeficiency 0 1 1683728 (1)


    Export disorders for HIST2H3C gene to outside databases

    Publications
    for HIST2H3C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H3C gene, integrated from 9 sources (see all 293):
    (articles sorted by number of sources associating them with HIST2H3C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. (PubMed id 15681610)1, 2, 9 Dai J.... Higgins J.M.G. (2005)
    3. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2, 9 Beck H.C.... Jensen O.N. (2006)
    4. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. (PubMed id 12560483)1, 2, 9 Preuss U.... Scheidtmann K.H. (2003)
    5. Histone H3 lysine 56 methylation regulates DNA replication through its interaction wwith PCNA. (PubMed id 22387026)1, 2 Yu Y.... Grunstein M. (2012)
    6. Phosphorylation of histone H3 at threonine 11 establi shes a novel chromatin mark for transcriptional regulation. (PubMed id 18066052)1, 2 Metzger E....SchA1le R. (2008)
    7. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. (PubMed id 18079182)1, 2 Hyllus D....Bauer U.M. (2007)
    8. Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. (PubMed id 17189264)1, 2 Morris S.A.... Strahl B.D. (2007)
    9. Organismal differences in post-translational modifications in histones H3 and H4. (PubMed id 17194708)1, 2 Garcia B.A.... Hunt D.F. (2007)
    10. Expression patterns and post-translational modifications associated with mammalian histone H3 variants. (PubMed id 16267050)1, 2 Hake S.B.... Hunt D.F. (2006)

    External Searches for HIST2H3C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST2H3C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126961 HGNC: 20503 Ensembl:ENSG00000203811 euGenes: HUgn126961 ECgene: HIST2H3C Kegg: 126961
    H-InvDB: HIST2H3C

    Other Databases showing HIST2H3C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST2H3C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H3C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST2H3C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST2H3C gene:
    Search GeneIP for patents involving HIST2H3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HIST2H3C gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST2H3C
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for HIST2H3C
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HIST2H3C  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST2H3C   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST2H3C  
     OriGene Protein Over-expression Lysate for HIST2H3C   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HIST2H3C   OriGene 3'-UTR Clone for HIST2H3C  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H3C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H3C  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST2H3C   OriGene Custom Protein Services for HIST2H3C  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST2H3C
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST2H3C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H3C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST2H3C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST2H3C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST2H3C
     GenScript Custom Purified and Recombinant Proteins Services for HIST2H3C GenScript cDNA clones with any tag delivered in your preferred vector for HIST2H3C
     GenScript Custom Assay Services for HIST2H3C GenScript Custom Superior Antibodies Services for HIST2H3C
     GenScript Custom overexpressing Cell Line Services for HIST2H3C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HIST2H3C promoter
     Search Chromatin IP Primers for HIST2H3C
     RT2 qPCR Primer Assay in human, mouse, rat HIST2H3C
     Search GNC Networks for HIST2H3C
     SABiosciences Custom PCR Arrays for HIST2H3C
     Search Tocris compounds for HIST2H3C
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for HIST2H3C
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HIST2H3C antibodies
     HIST2H3C proteins
     HIST2H3C lysates
     Search for Antibodies for HIST2H3C at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HIST2H3C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HIST2H3C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HIST2H3C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST2H3C
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST2H3C
     SwitchGear Promoter luciferase reporter plasmids for HIST2H3C
     ThermoFisher Antibodies for HIST2H3C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H3C
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HIST2H3C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4