Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST2H3C Gene

Aliases for HIST2H3C Gene

  • Histone Cluster 2 H3 Family Member C 2 3 5
  • H3 Histone Family, Member M 2 3
  • Histone Cluster 2, H3c 2 3
  • Histone 2, H3c 2 3
  • Histone H3/M 3 4
  • H3F2 3 4
  • H3FM 3 4
  • HIST2H3A HIST2H3C HIST2H3D 4
  • H3 Histone, Family 2 3
  • Histone H3.2 3
  • Histone H3/O 4
  • H3.2 3
  • H3/M 3
  • H3FN 3
  • H3 3

External Ids for HIST2H3C Gene

Previous HGNC Symbols for HIST2H3C Gene

  • H3F2
  • H3FM

Previous GeneCards Identifiers for HIST2H3C Gene

  • GC01M145553
  • GC01M146586
  • GC01M147028
  • GC01M147001
  • GC01M146598
  • GC01U901205
  • GC01M148078
  • GC01M149812
  • GC01P121206

Summaries for HIST2H3C Gene

Entrez Gene Summary for HIST2H3C Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST2H3C Gene

HIST2H3C (Histone Cluster 2 H3 Family Member C) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Immune System. GO annotations related to this gene include protein heterodimerization activity and histone binding. An important paralog of this gene is HIST2H3A.

UniProtKB/Swiss-Prot for HIST2H3C Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST2H3C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H3C Gene

Genomics for HIST2H3C Gene

Regulatory Elements for HIST2H3C Gene

Enhancers for HIST2H3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F150061 0.9 Ensembl ENCODE 10.3 -220.6 -220641 0.9 PKNOX1 CEBPB SIN3A TSHZ1 JUND ZNF316 PBX2 FOS MAFK HIST2H2AC OTUD7B MTMR11 PLEKHO1 HIST2H2AA3 HIST2H2BD HIST2H3C SF3B4 HIST2H2BE BOLA1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST2H3C on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST2H3C Gene

Chromosome:
1
Start:
149,839,538 bp from pter
End:
149,841,193 bp from pter
Size:
1,656 bases
Orientation:
Minus strand

Genomic View for HIST2H3C Gene

Genes around HIST2H3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H3C Gene

Proteins for HIST2H3C Gene

  • Protein details for HIST2H3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71DI3-H32_HUMAN
    Recommended name:
    Histone H3.2
    Protein Accession:
    Q71DI3
    Secondary Accessions:
    • A2BDF6
    • A6NFS4
    • Q6B053

    Protein attributes for HIST2H3C Gene

    Size:
    136 amino acids
    Molecular mass:
    15388 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer.

    Three dimensional structures from OCA and Proteopedia for HIST2H3C Gene

neXtProt entry for HIST2H3C Gene

Post-translational modifications for HIST2H3C Gene

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (PubMed:22483618).
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
  • Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
  • Ubiquitination at Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST2H3C Gene

Domains & Families for HIST2H3C Gene

Gene Families for HIST2H3C Gene

Protein Domains for HIST2H3C Gene

Graphical View of Domain Structure for InterPro Entry

Q71DI3

UniProtKB/Swiss-Prot:

H32_HUMAN :
  • Belongs to the histone H3 family.
Family:
  • Belongs to the histone H3 family.
genes like me logo Genes that share domains with HIST2H3C: view

No data available for Suggested Antigen Peptide Sequences for HIST2H3C Gene

Function for HIST2H3C Gene

Molecular function for HIST2H3C Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST2H3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20580717
GO:0031492 nucleosomal DNA binding IBA --
GO:0042393 histone binding IPI 25615412
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H3C: view

Phenotypes for HIST2H3C Gene

genes like me logo Genes that share phenotypes with HIST2H3C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H3C Gene

Localization for HIST2H3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H3C Gene

Gene Ontology (GO) - Cellular Components for HIST2H3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 21636898
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HIST2H3C: view

No data available for Subcellular locations from COMPARTMENTS for HIST2H3C Gene

Pathways & Interactions for HIST2H3C Gene

SuperPathways for HIST2H3C Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 Cellular Senescence
3 Cell Cycle, Mitotic
.60
4 Chromatin organization
5 Mitotic Prophase
genes like me logo Genes that share pathways with HIST2H3C: view

Gene Ontology (GO) - Biological Process for HIST2H3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006334 nucleosome assembly IDA 21636898
GO:0007596 blood coagulation TAS --
GO:0031047 gene silencing by RNA TAS --
genes like me logo Genes that share ontologies with HIST2H3C: view

No data available for SIGNOR curated interactions for HIST2H3C Gene

Drugs & Compounds for HIST2H3C Gene

(7) Drugs for HIST2H3C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for HIST2H3C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HIST2H3C: view

Transcripts for HIST2H3C Gene

mRNA/cDNA for HIST2H3C Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H3C Gene

Histone cluster 2, H3c:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H3C Gene

No ASD Table

Relevant External Links for HIST2H3C Gene

GeneLoc Exon Structure for
HIST2H3C
ECgene alternative splicing isoforms for
HIST2H3C

Expression for HIST2H3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HIST2H3C Gene

mRNA expression in normal human tissues for HIST2H3C Gene

Protein differential expression in normal tissues from HIPED for HIST2H3C Gene

This gene is overexpressed in Heart (35.7) and Urine (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST2H3C Gene



Protein tissue co-expression partners for HIST2H3C Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST2H3C Gene:

HIST2H3C

SOURCE GeneReport for Unigene cluster for HIST2H3C Gene:

Hs.647745
genes like me logo Genes that share expression patterns with HIST2H3C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST2H3C Gene

Orthologs for HIST2H3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIST2H3C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 100 (a)
ManyToMany
LOC781224 34
  • 77.45 (n)
mouse
(Mus musculus)
Mammalia Hist2h3c2 35
  • 100 (a)
ManyToMany
H3f3c 34 16
  • 77.45 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 97 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC469476 34
  • 96.81 (n)
rat
(Rattus norvegicus)
Mammalia H3f3c 34
  • 77.94 (n)
dog
(Canis familiaris)
Mammalia LOC100856221 34
  • 76.54 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 100 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486720 34
  • 85.54 (n)
zebrafish
(Danio rerio)
Actinopterygii hist2h3c 35
  • 100 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta His3:CG33809 35
  • 100 (a)
OneToOne
His3:CG33824 34
  • 81.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012709 34
  • 84.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSE4 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 100 (a)
ManyToMany
Species where no ortholog for HIST2H3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST2H3C Gene

ENSEMBL:
Gene Tree for HIST2H3C (if available)
TreeFam:
Gene Tree for HIST2H3C (if available)

Paralogs for HIST2H3C Gene

(16) SIMAP similar genes for HIST2H3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST2H3C: view

Variants for HIST2H3C Gene

Sequence variations from dbSNP and Humsavar for HIST2H3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs200138530 -- 149,842,299(+) CGGAC(A/G)TCAGC upstream-variant-2KB, utr-variant-3-prime
rs587598971 -- 149,843,174(+) AGGTG(C/T)TGAAG upstream-variant-2KB
rs587606541 -- 149,842,838(+) GTCCC(A/G)ATAGC upstream-variant-2KB
rs587663186 -- 149,842,873(+) CACTC(A/C)TTTAC upstream-variant-2KB
rs587707994 -- 149,842,837(+) TGTCC(A/C)GATAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST2H3C Gene

Variant ID Type Subtype PubMed ID
esv1007634 OTHER inversion 20482838
nsv46 OTHER inversion 15895083
nsv469694 CNV loss 16826518
nsv499132 OTHER inversion 21111241
nsv547843 CNV loss 21841781
nsv7182 OTHER inversion 18451855
nsv824564 CNV gain 20364138
nsv831503 CNV gain 17160897
nsv831525 CNV gain 17160897
nsv946379 CNV duplication 23825009
nsv946381 CNV duplication 23825009

Relevant External Links for HIST2H3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST2H3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H3C Gene

Disorders for HIST2H3C Gene

Relevant External Links for HIST2H3C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST2H3C

No disorders were found for HIST2H3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H3C Gene

Publications for HIST2H3C Gene

  1. Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 4 22 64
  2. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. (PMID: 15681610) Dai J. … Higgins J.M.G. (Genes Dev. 2005) 3 4 22 64
  3. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. (PMID: 12560483) Preuss U. … Scheidtmann K.H. (Nucleic Acids Res. 2003) 3 4 22 64
  4. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  5. Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. (PMID: 22387026) Yu Y. … Grunstein M. (Mol. Cell 2012) 3 4 64

Products for HIST2H3C Gene

Sources for HIST2H3C Gene

Content
Loading form....