Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIST2H2BF Gene

protein-coding   GIFtS: 49
GCID: GC01M149769

Histone Cluster 2, H2bf

(Previous names: histone 2, H2bf)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histone Cluster 2, H2bf1 2
Histone 2, H2bf1
Histone H2B Type 2-F2

External Ids:    HGNC: 247001   Entrez Gene: 4406892   Ensembl: ENSG000002038147   UniProtKB: Q5QNW63   

Export aliases for HIST2H2BF gene to outside databases

Previous GC identifers: GC01M146591 GC01M148048 GC01M149765 GC01M149758 GC01M149760 GC01M149761 GC01M149762 GC01M149763 GC01M149764 GC01M149767


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIST2H2BF Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer
composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further
compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher
order chromatin structures. This gene encodes a member of the histone H2B family and is found in a histone
cluster on chromosome 1. (provided by RefSeq, Jan 2013)

GeneCards Summary for HIST2H2BF Gene:
HIST2H2BF (histone cluster 2, H2bf) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST2H2BF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST2H2BF gene promoter:
         AML1a   Olf-1   CUTL1   Tal-1beta   CBF-C   POU2F1   POU2F1a   POU2F1b   POU2F1c   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST2H2BF promoter sequence
   Search Chromatin IP Primers for HIST2H2BF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H2BF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2BF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2BF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149769:  view genomic region     (about GC identifiers)

Start:
149,754,245 bp from pter      End:
149,783,928 bp from pter
Size:
29,684 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6 (See protein sequence)
Recommended Name: Histone H2B type 2-F  
Size: 126 amino acids; 13920 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Secondary accessions: A8K0U9 B4DLA9
Alternative splicing: 2 isoforms:  Q5QNW6-1   Q5QNW6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HIST2H2BF: NX_Q5QNW6

Explore proteomics data for HIST2H2BF at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as
    a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a
    large set of exons1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys44, Lys47, Lys58, Lys109, Lys117, Lys121
  • Glycosylation2 at Ser113
  • Modification sites at PhosphoSitePlus

  • See HIST2H2BF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019770.1  NP_001154806.1  

    ENSEMBL proteins: 
     ENSP00000358164   ENSP00000445831   ENSP00000407461  
    Reactome Protein details: Q5QNW6

    HIST2H2BF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HIST2H2BF
    OriGene Protein Over-expression Lysate for HIST2H2BF
    OriGene MassSpec for HIST2H2BF
    OriGene Custom Protein Services for HIST2H2BF
    GenScript Custom Purified and Recombinant Proteins Services for HIST2H2BF
    Novus Biologicals HIST2H2BF Proteins
    Novus Biologicals HIST2H2BF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST2H2BF

     
    Search eBioscience for Proteins for HIST2H2BF 

     
    Search antibodies-online for proteins for HIST2H2BF 

     
    antibodies-online peptides for HIST2H2BF

    HIST2H2BF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HIST2H2BF
    OriGene Custom Antibody Services for HIST2H2BF
    Novus Biologicals HIST2H2BF Antibodies
    Abcam antibodies for HIST2H2BF
    Cloud-Clone Corp. Antibodies for HIST2H2BF
    Search ThermoFisher Antibodies for HIST2H2BF
    LSBio Antibodies in human, mouse, rat for HIST2H2BF
    antibodies-online antibodies for HIST2H2BF (10 products) 

    HIST2H2BF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIST2H2BF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST2H2BF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST2H2BF
    Cloud-Clone Corp. CLIAs for HIST2H2BF
    Search eBioscience for ELISAs for HIST2H2BF 
    antibodies-online kits for HIST2H2BF (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q5QNW6

    ProtoNet protein and cluster: Q5QNW6

    UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6
    Similarity: Belongs to the histone H2B family


    Find genes that share domains with HIST2H2BF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B2F_HUMAN, Q5QNW6
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST2H2BF           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST2H2BF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST2H2BF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST2H2BF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST2H2BF

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST2H2BF:
    hsa-mir-615-3p (MIRT039890), hsa-mir-25-3p (MIRT050231), hsa-let-7a-5p (MIRT052377), hsa-mir-296-3p (MIRT038403), hsa-mir-1180-3p (MIRT035952), hsa-let-7e-5p (MIRT051429), hsa-mir-125b-5p (MIRT045913), hsa-mir-26b-5p (MIRT029014), hsa-mir-98-5p (MIRT027483), hsa-mir-18a-3p (MIRT040749), hsa-mir-423-5p (MIRT038115), hsa-mir-99b-3p (MIRT038517), hsa-mir-760 (MIRT036796)

    Block miRNA regulation of human, mouse, rat HIST2H2BF using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST2H2BF:
    hsa-miR-146a* hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidHIST2H2BF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIST2H2BF
    Predesigned siRNA for gene silencing in human, mouse, rat HIST2H2BF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST2H2BF

    Clone
    Products:
         
    OriGene clones in human, mouse for HIST2H2BF (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HIST2H2BF (NM_001024599)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST2H2BF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2BF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST2H2BF
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIST2H2BF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2BF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    H2B2F_HUMAN, Q5QNW6: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with HIST2H2BF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HIST2H2BF About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    Chromatin organization0.34
    HATs acetylate histones0.34
    Alcoholism0.34
    Chromatin modifying enzymes0.34
    2Viral carcinogenesis
    Viral carcinogenesis


    Find genes that share SuperPaths with HIST2H2BF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HIST2H2BF
        HATs acetylate histones


    3 Kegg Pathways  (Kegg details for HIST2H2BF):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST2H2BF
    Interactions:

        Search GeneGlobe Interaction Network for HIST2H2BF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST2H2BF (Q5QNW62, 3 ENSP000003581644) via UniProtKB, MINT, STRING, and/or I2D (see all 346)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=11 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=11 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=11 
    HIST1H4BP628053I2D: score=11 
    HIST1H4CP628053I2D: score=11 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006334nucleosome assembly IEA--

    Find genes that share ontologies with HIST2H2BF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST2H2BF (H2B2F)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIST2H2BF gene (2 alternative transcripts): 
    NM_001024599.4  NM_001161334.1  

    Unigene Cluster for HIST2H2BF:

    Histone cluster 2, H2bf
    Hs.632451  [show with all ESTs]
    Unigene Representative Sequence: AK092418
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469483 ENST00000369167(uc001esr.3) ENST00000545683(uc010pbj.2)
    ENST00000427880(uc010pbk.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIST2H2BF using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST2H2BF:
    hsa-miR-146a* hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidHIST2H2BF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIST2H2BF
    Predesigned siRNA for gene silencing in human, mouse, rat HIST2H2BF
    Clone
    Products:
         
    OriGene clones in human, mouse for HIST2H2BF (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HIST2H2BF (NM_001024599)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST2H2BF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2BF
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST2H2BF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST2H2BF
      QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2BF
      QuantiFast Probe-based Assays in human, mouse, rat HIST2H2BF

    Additional mRNA sequence: 

    AK092418.1 AK289664.1 AK296916.1 AK299108.1 BC110793.1 

    9 DOTS entries:

    DT.92010992  DT.40219799  DT.114591  DT.100750836  DT.100855754  DT.121372893  DT.91802516  DT.95072607 
    DT.95258191 

    7 AceView cDNA sequences:

    BX282515 BI835621 BE742212 BI836145 CD698245 AI147174 AI660196 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIST2H2BF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST2H2BF Expression
    About this image

    HIST2H2BF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST2H2BF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632451
        Custom PCR Arrays for HIST2H2BF
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST2H2BF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST2H2BF
    QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2BF
    QuantiFast Probe-based Assays in human, mouse, rat HIST2H2BF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2BF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for HIST2H2BF gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist2h2bb1 histone cluster 2, H2bb 88.36(n)
    100(a)
      319189  NM_175666.2  NP_783597.2 


    ENSEMBL Gene Tree for HIST2H2BF (if available)
    TreeFam Gene Tree for HIST2H2BF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIST2H2BF gene
    HIST1H2BN2  HIST1H2BD2  HIST1H2BC2  HIST1H2BE2  HIST1H2BB2  HIST1H2BM2  HIST3H2BB2  HIST1H2BK2  
    HIST1H2BI2  HIST1H2BG2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BF2  HIST2H2BE2  
    Selected SIMAP similar genes for HIST2H2BF using alignment to 2 protein entries:     H2B2F_HUMAN (see all proteins) (see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH
    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BM    HIST1H2BO    HIST2H2BE
    HIST3H2BB    HIST1H2BN    HIST1H2BC    H2BFS    HIST1H2BL    ABCF2

    Find genes that share paralogs with HIST2H2BF           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HIST2H2BF
    PGOHUM00000251085 PGOHUM00000260110


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIST2H2BF (see all 493)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996359291,2
    C,F--156256177(+) TTCACT/CGCTCC 1 -- ut311Minor allele frequency- C:0.01EU 903
    rs2007542231,2
    C--156256187(+) CCACCA/GGCTTG 1 -- ut311Minor allele frequency- G:0.00EU 957
    rs1415986611,2
    C,F--156256221(+) ACTCTG/ACTCCT 1 -- ut312Minor allele frequency- A:0.01NA EU 4375
    rs1384477151,2
    C,F--156257462(+) TAGACA/GCCACA 1 -- int11Minor allele frequency- G:0.00EU 1319
    rs1483734941,2
    C,F--156257521(+) GAAACC/TGTAAC 1 -- int12Minor allele frequency- T:0.01NA EU 5815
    rs1499268131,2
    F--156257596(+) GCCACT/CCAGAC 1 -- int11Minor allele frequency- C:0.01NA 4552
    rs1440810761,2
    C--156257604(+) GACCTC/TGACCC 1 -- int11Minor allele frequency- T:0.00NA 4552
    rs2022210561,2
    F--156257766(+) TCTGCA/G/TTTCTC 1 -- int11EU 1324
    rs1492884101,2
    --156257968(+) GTATCA/GTTATT 1 -- int10--------
    rs1445652591,2
    --156258080(+) CACCTC/TCCACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for HIST2H2BF (149754245 - 149783928 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HIST2H2BF (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436282CNV Deletion17901297
    esv2421626CNV Deletion20811451
    esv2658545CNV Deletion23128226
    dgv20n16CNV Deletion17901297
    dgv19n16CNV Insertion17901297
    dgv7e55CNV Loss17911159
    dgv375n71CNV Loss21882294
    nsv469694CNV Loss16826518
    nsv508604CNV Loss20534489
    nsv470736CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST2H2BF
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H2BF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIST2H2BF gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with HIST2H2BF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2 Bonenfant D.... van Oostrum J. (Mol. Cell. Proteomics 2006)
    2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (Mol. Cell. Biochem. 2005)
    5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)1, 2 Cheung W.L.... Allis C.D. (Cell 2003)
    9. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    10. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PubMed id 23824326)2 Zhang Z....Wang H. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 440689 HGNC: 24700 AceView: LOC440689 Ensembl:ENSG00000203814 euGenes: HUgn440689
    ECgene: HIST2H2BF Kegg: 440689 H-InvDB: HIST2H2BF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIST2H2BF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIST2H2BF gene:
    Search GeneIP for patents involving HIST2H2BF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HIST2H2BF   OriGene RNAi products in human, mouse, rat for HIST2H2BF  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HIST2H2BF  
     OriGene MassSpec for HIST2H2BF   OriGene clones in human, mouse for HIST2H2BF  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIST2H2BF   OriGene Purified Protein for HIST2H2BF  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST2H2BF   OriGene Custom Protein Services for HIST2H2BF  

     
     
     Block miRNA regulation of human, mouse, rat HIST2H2BF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIST2H2BF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H2BF Predesigned siRNA for gene silencing in human, mouse, rat HIST2H2BF
     QuantiFast Probe-based Assays in human, mouse, rat HIST2H2BF QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2BF
     Custom PCR Arrays for HIST2H2BF Search Chromatin IP Primers for HIST2H2BF
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST2H2BF  Search GeneGlobe Interaction Network for HIST2H2BF
     Regulatory tfbs in HIST2H2BF promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIST2H2BF GenScript cDNA clones with any tag delivered in your preferred vector for HIST2H2BF
     GenScript Custom Assay Services for HIST2H2BF GenScript Custom overexpressing Cell Line Services for HIST2H2BF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HIST2H2BF (H2B2F)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HIST2H2BF antibodies
     HIST2H2BF proteins
     HIST2H2BF lysates
     Antibodies for HIST2H2BF
     See all of Abcam's Antibodies, Kits and Proteins for HIST2H2BF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIST2H2BF
     Antibodies for HIST2H2BF
     ELISAs for HIST2H2BF
     CLIAs for HIST2H2BF



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIST2H2BF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2BF
     SwitchGear 3'UTR luciferase reporter plasmids for HIST2H2BF
     SwitchGear Promoter luciferase reporter plasmids for HIST2H2BF
     Search ThermoFisher Antibodies for HIST2H2BF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2BF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST2H2BF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST2H2BF
     LSBio Antibodies in human, mouse, rat for HIST2H2BF
     Browse compounds at ApexBio
     Search Addgene for plasmids for HIST2H2BF
      Search eBioscience for proteins for HIST2H2BF
      Search eBioscience for elisas for HIST2H2BF
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for HIST2H2BF (10 products)
     antibodies-online kits for HIST2H2BF (2 products)
     antibodies-online peptides for HIST2H2BF
      Search antibodies-online for proteins for HIST2H2BF
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST2H2BF gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4