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Aliases for HIST2H2BF Gene

Aliases for HIST2H2BF Gene

  • Histone Cluster 2, H2bf 2 3
  • Histone 2, H2bf 2

External Ids for HIST2H2BF Gene

Previous GeneCards Identifiers for HIST2H2BF Gene

  • GC01M146591
  • GC01M148048
  • GC01M149765
  • GC01M149758
  • GC01M149760
  • GC01M149761
  • GC01M149762
  • GC01M149763
  • GC01M149764
  • GC01M149767
  • GC01M149769

Summaries for HIST2H2BF Gene

Entrez Gene Summary for HIST2H2BF Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Jan 2013]

GeneCards Summary for HIST2H2BF Gene

HIST2H2BF (Histone Cluster 2, H2bf) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot for HIST2H2BF Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H2BF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BF Gene

Genomics for HIST2H2BF Gene

Regulatory Elements for HIST2H2BF Gene

Genomic Location for HIST2H2BF Gene

149,756,263 bp from pter
149,812,410 bp from pter
56,148 bases
Minus strand

Genomic View for HIST2H2BF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST2H2BF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BF Gene

Proteins for HIST2H2BF Gene

  • Protein details for HIST2H2BF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H2B type 2-F
    Protein Accession:
    Secondary Accessions:
    • A8K0U9
    • B4DLA9

    Protein attributes for HIST2H2BF Gene

    126 amino acids
    Molecular mass:
    13920 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Alternative splice isoforms for HIST2H2BF Gene


neXtProt entry for HIST2H2BF Gene

Proteomics data for HIST2H2BF Gene at MOPED

Post-translational modifications for HIST2H2BF Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H2BF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST2H2BF Gene

Domains for HIST2H2BF Gene

Gene Families for HIST2H2BF Gene

  • HIST :Histones / Replication-dependent

Protein Domains for HIST2H2BF Gene

Suggested Antigen Peptide Sequences for HIST2H2BF Gene

Graphical View of Domain Structure for InterPro Entry



  • Q5QNW6
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BF: view

Function for HIST2H2BF Gene

Molecular function for HIST2H2BF Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST2H2BF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H2BF: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST2H2BF Gene

Localization for HIST2H2BF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BF Gene

Nucleus. Chromosome.

Subcellular locations from

Jensen Localization Image for HIST2H2BF Gene COMPARTMENTS Subcellular localization image for HIST2H2BF gene
Compartment Confidence
nucleus 5
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HIST2H2BF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome --
GO:0000788 nuclear nucleosome IBA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST2H2BF: view

Pathways for HIST2H2BF Gene

genes like me logo Genes that share pathways with HIST2H2BF: view

Pathways by source for HIST2H2BF Gene

Gene Ontology (GO) - Biological Process for HIST2H2BF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly IBA --
genes like me logo Genes that share ontologies with HIST2H2BF: view

Transcripts for HIST2H2BF Gene

mRNA/cDNA for HIST2H2BF Gene

(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2BF Gene

Histone cluster 2, H2bf:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H2BF

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST2H2BF
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BF Gene

No ASD Table

Relevant External Links for HIST2H2BF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIST2H2BF Gene

mRNA expression in normal human tissues for HIST2H2BF Gene

mRNA differential expression in normal tissues according to GTEx for HIST2H2BF Gene

This gene is overexpressed in Whole Blood (13.3) and Cervix - Ectocervix (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST2H2BF Gene

SOURCE GeneReport for Unigene cluster for HIST2H2BF Gene Hs.632451

genes like me logo Genes that share expressions with HIST2H2BF: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST2H2BF Gene

Orthologs for HIST2H2BF Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST2H2BF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIST2H2BF 36
  • 75 (a)
LOC457260 35
  • 99.75 (n)
  • 100 (a)
(Bos Taurus)
Mammalia H2B 36
  • 99 (a)
LOC505183 35
  • 89.68 (n)
  • 98.41 (a)
(Canis familiaris)
Mammalia HIST2H2BF 36
  • 92 (a)
LOC608682 35
  • 89.22 (n)
  • 95.49 (a)
(Mus musculus)
Mammalia Hist2h2bb 35
  • 88.36 (n)
  • 100 (a)
Hist2h2bb 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
-- 36
  • 93 (a)
(Rattus norvegicus)
Mammalia LOC100912338 35
  • 88.36 (n)
  • 100 (a)
Species with no ortholog for HIST2H2BF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST2H2BF Gene

Gene Tree for HIST2H2BF (if available)
Gene Tree for HIST2H2BF (if available)

Paralogs for HIST2H2BF Gene Pseudogenes for HIST2H2BF Gene

genes like me logo Genes that share paralogs with HIST2H2BF: view

Variants for HIST2H2BF Gene

Sequence variations from dbSNP and Humsavar for HIST2H2BF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs589976 -- 149,803,769(+) GTAGG(A/G)CCACC intron-variant, utr-variant-3-prime
rs590366 -- 149,803,837(+) TCTTC(C/G)GACTC intron-variant, utr-variant-3-prime
rs591236 -- 149,770,293(+) tcagc(C/T)tcctg intron-variant
rs592998 -- 149,797,800(+) gccat(A/G)ttgtc intron-variant
rs595169 -- 149,758,144(+) GACAC(C/T)TATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BF Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
dgv7e55 CNV Loss 17911159
esv2750807 CNV Gain 17911159
dgv122e1 CNV Complex 17122850
nsv508604 CNV Loss 20534489
esv33539 CNV Gain+Loss 17666407
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
dgv362n71 CNV Gain 21882294
dgv126e1 CNV Complex 17122850
nsv872306 CNV Gain 21882294
dgv368n71 CNV Gain 21882294
nsv8302 CNV Gain 18304495
esv21838 CNV Gain+Loss 19812545
nsv470736 CNV Gain 18288195
esv2750809 CNV Gain 17911159
dgv375n71 CNV Loss 21882294
nsv872378 CNV Gain 21882294
dgv376n71 CNV Gain 21882294
nsv872384 CNV Gain 21882294
dgv19n16 CNV Insertion 17901297
esv2421626 CNV Deletion 20811451
esv2658545 CNV Deletion 23128226
dgv378n71 CNV Gain 21882294
nsv436282 CNV Deletion 17901297
dgv20n16 CNV Deletion 17901297
dgv380n71 CNV Gain+Loss 21882294
dgv381n71 CNV Gain 21882294
esv21909 CNV Gain 19812545
dgv73n67 CNV Gain 20364138
nsv824564 CNV Gain 20364138
nsv831503 CNV Gain 17160897
nsv469694 CNV Loss 16826518
nsv831525 CNV Gain 17160897
nsv872414 CNV Gain 21882294
essv23032 CNV CNV 17122850
esv1007634 OTHER Inversion 20482838
nsv7182 OTHER Inversion 18451855

Relevant External Links for HIST2H2BF Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H2BF Gene

Disorders for HIST2H2BF Gene

No disorders were found for HIST2H2BF Gene.

No data available for UniProtKB/Swiss-Prot for HIST2H2BF Gene

Publications for HIST2H2BF Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R. … Reinberg D. (Cell 2006) 3 4
  3. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HIST2H2BF Gene

Sources for HIST2H2BF Gene

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