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HIST2H2BE Gene

protein-coding   GIFtS: 57
GCID: GC01M149856

Histone Cluster 2, H2be

(Previous names: H2B histone family, member Q, histone 2, H2be)
(Previous symbols: H2B, H2BFQ)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 2, H2be1 2     GL1052
H2BFQ1 2 3     H2B.12
H2B1 2 5     H2BGL1052
H2B Histone Family, Member Q1 2     H2BQ2
Histone 2, H2be1 2     Histone H2B Type 2-E2
Histone H2B-GL1052 3     H2B/q3
Histone H2B.Q2 3     

External Ids:    HGNC: 47601   Entrez Gene: 83492   Ensembl: ENSG000001846787   OMIM: 6018315   UniProtKB: Q167783   

Export aliases for HIST2H2BE gene to outside databases

Previous GC identifers: GC01M145598 GC01M146631 GC01M147072 GC01M146669 GC01M148122 GC01M148082 GC01M121237


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST2H2BE Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the
conserved stem-loop termination motif, and the polyA addition motif. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST2H2BE Gene:
HIST2H2BE (histone cluster 2, H2be) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot: H2B2E_HUMAN, Q16778
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST2H2BE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST2H2BE gene promoter:
         TBP   POU3F1   GCNF   GCNF-1   ARP-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST2H2BE promoter sequence
   Search Chromatin IP Primers for HIST2H2BE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H2BE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2BE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2BE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149856:  view genomic region     (about GC identifiers)

Start:
149,856,010 bp from pter      End:
149,858,232 bp from pter
Size:
2,223 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: H2B2E_HUMAN, Q16778 (See protein sequence)
Recommended Name: Histone H2B type 2-E  
Size: 126 amino acids; 13920 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Secondary accessions: A3KMC7 A8K110 Q4KMY1 Q5QNX0 Q9UE88

Explore the universe of human proteins at neXtProt for HIST2H2BE: NX_Q16778

Explore proteomics data for HIST2H2BE at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as
    a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a
    large set of exons1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys6, Lys44, Lys47, Lys58, Lys109, Lys117, Lys121
  • Glycosylation2 at Ser113
  • Modification sites at PhosphoSitePlus

  • See HIST2H2BE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003519.1  
    ENSEMBL proteins: 
     ENSP00000358151  
    Reactome Protein details: Q16778

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q16778

    ProtoNet protein and cluster: Q16778

    UniProtKB/Swiss-Prot: H2B2E_HUMAN, Q16778
    Similarity: Belongs to the histone H2B family


    Find genes that share domains with HIST2H2BE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B2E_HUMAN, Q16778
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling
    Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
    barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS1469070
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST2H2BE           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HIST2H2BE:
     Increased cell number in G2M,  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hist2h2be):
     cellular  craniofacial  nervous system  respiratory system  taste/olfaction 

    Find genes that share phenotypes with HIST2H2BE           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HIST2H2BE

    miRNA
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    miRTarBase miRNAs that target HIST2H2BE:
    hsa-let-7a-5p (MIRT052380), hsa-mir-615-3p (MIRT040129), hsa-mir-103a-3p (MIRT027073), hsa-mir-34a-5p (MIRT025415), hsa-mir-877-3p (MIRT037085), hsa-mir-16-5p (MIRT031573), hsa-mir-423-5p (MIRT038016), hsa-mir-296-3p (MIRT038396)

    Block miRNA regulation of human, mouse, rat HIST2H2BE using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HIST2H2BE:
    hsa-miR-146a* hsa-miR-1276 hsa-miR-339-3p hsa-miR-1293 hsa-miR-1207-5p hsa-miR-3647-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidHIST2H2BE 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2B2E_HUMAN, Q16778: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS1469070
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with HIST2H2BE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST2H2BE About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with HIST2H2BE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for HIST2H2BE
        Signal transduction Activin A signaling regulation


    Selected Reactome Pathways for HIST2H2BE (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST2H2BE):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST2H2BE
    Interactions:

        GeneGlobe Interaction Network for HIST2H2BE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST2H2BE (Q167782, 3 ENSP000003581514) via UniProtKB, MINT, STRING, and/or I2D (see all 241)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006334nucleosome assembly NAS1469070
    GO:0042742defense response to bacterium IEA--

    Find genes that share ontologies with HIST2H2BE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HIST2H2BE (H2B2E)

    4 Novoseek inferred chemical compound relationships for HIST2H2BE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactacystin 39.6 1 9398160 (1)
    adpribose 27.5 1 1736995 (1)
    butyrate 14.5 1 16457587 (1)
    atp 0 3 10402647 (2)



    Find genes that share compounds with HIST2H2BE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST2H2BE gene: 
    NM_003528.2  

    Unigene Cluster for HIST2H2BE:

    Histone cluster 2, H2be
    Hs.2178  [show with all ESTs]
    Unigene Representative Sequence: BC069193
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369155(uc001etc.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2BE
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    Additional mRNA sequence: 

    AK093747.1 BC005827.2 BC069193.1 BC096121.2 BC098112.1 BC098289.1 BC107084.1 BC107085.1 
    CR541895.1 M60756.1 

    11 DOTS entries:

    DT.95258191  DT.100773959  DT.447760  DT.100795660  DT.121432886  DT.100795657  DT.100795656  DT.100795662 
    DT.121432792  DT.95274152  DT.97858897 

    Selected AceView cDNA sequences (see all 254):

    AI421594 AI290080 BX101066 AA253354 BU509606 BQ879729 CD617176 F01679 
    AA098799 AA101805 AI868544 CD617180 AA234918 AI955256 AI675687 CR615793 
    BI915188 F02784 AA346453 AI422586 BI754194 AA825332 CR541895 AA195694 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST2H2BE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTTTTCA
    HIST2H2BE Expression
    About this image


    HIST2H2BE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
    HIST2H2BE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST2H2BE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2178
        Custom PCR Arrays for HIST2H2BE
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H2BE gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist2h2be5 histone cluster 2, H2be   --   3 (41.67 cM) 96221119 
    chicken
    (Gallus gallus)
    Aves H2B-I6
    Histone H2B 1/2/3/4/6
    97(a)
    many ↔ many
    1(48017424-48018082)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H2B
    94(a)
    many ↔ many
    GL343400.1(344844-345224)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ618222.12   -- 86.55(n)    BJ618222.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059463.12   -- 83.63(n)   386920  BC059463.1 
    soybean
    (Glycine max)
    eudicotyledons 467348742   -- 79.04(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.477142 Transcribed sequence with moderate similarity to protein more 84.25(n)    BU673208.1 


    ENSEMBL Gene Tree for HIST2H2BE (if available)
    TreeFam Gene Tree for HIST2H2BE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST2H2BE gene
    HIST1H2BN2  HIST1H2BD2  HIST1H2BC2  HIST1H2BE2  HIST1H2BB2  HIST1H2BM2  HIST3H2BB2  HIST1H2BK2  
    HIST1H2BI2  HIST1H2BG2  HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BF2  
    Selected SIMAP similar genes for HIST2H2BE using alignment to 1 protein entry:     H2B2E_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH
    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BM    HIST1H2BN    HIST1H2BO
    HIST2H2BF    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    ABCF2

    Find genes that share paralogs with HIST2H2BE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST2H2BE (see all 12)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431594931,2
    --149855555(+) CTAGGA/CGCTTA 1 -- ds50010--------
    rs1482785941,2
    --149855723(+) GCTCCA/GTAGGT 1 -- ds50010--------
    rs599566121,2
    C,F--149855734(+) GTTAGC/TTTAAC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs795557581,2
    C,F--149855904(+) ATCCCC/TCAGAT 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1417056091,2
    C--149855907(+) CCCCAC/GATCAG 1 -- ds50010--------
    rs1462523201,2
    --149855922(+) ACCCAC/TGCTTT 1 -- ds50010--------
    rs168418201,2
    C,F,H--149856147(+) CATCAG/ACTCCA 1 -- ut31 ese310Minor allele frequency- A:0.07NA NS WA 1054
    rs1379239841,2
    C--149856334(+) ACCAAC/TGAGGC 1 -- ut310--------
    rs159311,2
    C,F,H--149856350(+) TTGGCC/TTCATT 1 -- ut31 ese317Minor allele frequency- T:0.09MN NA NS EA 1714
    rs1873745001,2
    C--149856454(+) CTTTAA/GGAGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HIST2H2BE (149856010 - 149858232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HIST2H2BE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831537CNV Loss17160897
    nsv428235CNV Gain18775914
    nsv831525CNV Gain17160897
    esv2750807CNV Gain17911159
    essv23032CNV CNV17122850
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850
    dgv123e1CNV Complex17122850
    nsv7182OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST2H2BE
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H2BE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601831    OMIM disorders: --


    Find genes that share disorders with HIST2H2BE           About GenesLikeMe

    1 Novoseek inferred disease relationship for HIST2H2BE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 11812781 (1), 18832071 (1)


    Export disorders for HIST2H2BE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST2H2BE gene, integrated from 10 sources (see all 250):
    (articles sorted by number of sources associating them with HIST2H2BE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PubMed id 1469070)1, 2, 3, 9 Collart D.... Stein G.S. (J. Cell. Biochem. 1992)
    2. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    3. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2, 9 Beck H.C.... Jensen O.N. (Mol. Cell. Proteomics 2006)
    4. Gene-specific characterization of human histone H2B by electron capture dissociation. (PubMed id 16457587)1, 2, 9 Siuti N.... Pesavento J.J. (J. Proteome Res. 2006)
    5. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PubMed id 23824326)1, 2 Zhang Z....Wang H. (amp 2013)
    6. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. (PubMed id 21726816)1, 2 Wu L.... Dou Y. (Mol. Cell 2011)
    7. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (Mol. Cell. Biochem. 2005)
    10. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8349 HGNC: 4760 AceView: HIST2H2BE Ensembl:ENSG00000184678 euGenes: HUgn8349
    ECgene: HIST2H2BE Kegg: 8349 H-InvDB: HIST2H2BE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST2H2BE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST2H2BE gene:
    Search GeneIP for patents involving HIST2H2BE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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