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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H2BE Gene

protein-coding   GIFtS: 56
GCID: GC01M149856

histone cluster 2, H2be

(Previous names: H2B histone family, member Q, histone 2, H2be )
(Previous symbols: H2B, H2BFQ)
 Explore 15 diseases affiliated with
HIST2H2BE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST2H2BE    

Aliases
for HIST2H2BE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 2, H2be1 2     Histone H2B-GL1052 3
H2BFQ1 2 3     Histone H2B.Q2 3
H2B1 2 5     GL1052
H2B.11 2     H2BGL1052
H2B Histone Family, Member Q1 2     H2BQ2
Histone 2, H2be1 2     Histone H2B Type 2-E2
H2B/Q1     

External Ids:    HGNC: 47601   Entrez Gene: 83492   Ensembl: ENSG000001846787   OMIM: 6018315   UniProtKB: Q167783   

Export aliases for HIST2H2BE gene to outside databases

Previous GC identifers: GC01M145598 GC01M146631 GC01M147072 GC01M146669 GC01M148122 GC01M148082 GC01M121237


Summaries
for HIST2H2BE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST2H2BE:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene
encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop
termination motif, and the polyA addition motif. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2B2E_HUMAN, Q16778
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of
the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST2H2BE


Genomic Views
for HIST2H2BE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H2BE gene promoter:
         TBP   POU3F1   GCNF   GCNF-1   ARP-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST2H2BE promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST2H2BE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H2BE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2BE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2BE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149856:  view genomic region     (about GC identifiers)

Start:
 149,856,010 bp from pter      End:
 149,858,232 bp from pter
Size:
 2,223 bases      Orientation:
 minus strand

Proteins
for HIST2H2BE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2B2E_HUMAN, Q16778 (See protein sequence)
Recommended Name: Histone H2B type 2-E  
Size: 126 amino acids; 13920 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Secondary accessions: A3KMC7 A8K110 Q4KMY1 Q5QNX0 Q9UE88

Explore the universe of human proteins at neXtProt for HIST2H2BE: NX_Q16778

Post-translational modifications:

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79'
    • (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly,
    monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional
    activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively
    with the FACT dimer to stimulate elongation by RNA polymerase II1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    • Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation.
    Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic
    hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose,
    • and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16778

    • HIST2H2BE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003519.1  
    ENSEMBL proteins: 
     ENSP00000358151  
    Reactome Protein details: Q16778
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HIST2H2BE
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    Novus Biologicals HIST2H2BE Proteins
    Novus Biologicals HIST2H2BE Lysate
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    Uscn Proteins for HIST2H2BE

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS1469070
    GO:0005634nucleus IEA--


    HIST2H2BE for ontologies           About GeneDecksing



    HIST2H2BE Antibody Products: 
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    Uscn Antibodies for HIST2H2BE
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    Assay Products for HIST2H2BE: 
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    Uscn ELISAs and CLIAs for HIST2H2BE

    Protein Domains /
    Families
    for HIST2H2BE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST2H2BE for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q16778

    ProtoNet protein and cluster: Q16778

    UniProtKB/Swiss-Prot: H2B2E_HUMAN, Q16778
    Similarity: Belongs to the histone H2B family


    Function
    for HIST2H2BE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2B2E_HUMAN, Q16778
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling
    Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of
    the colonic epithelium, and to the bactericidal activity of amniotic fluid

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST2H2BE:
    hsa-miR-146a* hsa-miR-1276 hsa-miR-339-3p hsa-miR-1293 hsa-miR-1207-5p hsa-miR-3647-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: HIST2H2BE 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS1469070
    GO:0046982protein heterodimerization activity IEA--


    HIST2H2BE for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIST2H2BE:
     Increased cell number in G2M,  


    Pathways & Interactions
    for HIST2H2BE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Packaging Of Telomere Ends0.54
    		Telomere clustering at the nuclear membrane0.82
    		Telomere Maintenance0.38
    		Meiosis0.70
    		Meiotic Recombination0.32
    		Chromosome Maintenance0.56
    2RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    3Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    4Formation of Meiotic Holliday Junction
    		Formation of Meiotic Holliday Junction1.00
    		Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    		Formation of Meiotic Heteroduplex0.83
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST2H2BE
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST2H2BE
        Signal transduction Activin A signaling regulation

    5/17        Reactome Pathways for HIST2H2BE (see all 17)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Disease


    1         Kegg Pathway  (Kegg details for HIST2H2BE):
        Systemic lupus erythematosus


    HIST2H2BE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST2H2BE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/199 Interacting proteins for HIST2H2BE (Q167782, 3 ENSP000003581514) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS1469070
    GO:0042742defense response to bacterium IEA--


    HIST2H2BE for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST2H2BE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIST2H2BE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H2BE
    4 Novoseek chemical compound relationships for HIST2H2BE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactacystin 39.6 1 9398160 (1)
    adpribose 27.5 1 1736995 (1)
    butyrate 14.5 1 16457587 (1)
    atp 0 3 10402647 (2)

    Search CenterWatch for drugs/clinical trials and news about HIST2H2BE / H2B2E 

    Transcripts
    for HIST2H2BE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST2H2BE gene: 
    NM_003528.2  

    Unigene Cluster for HIST2H2BE:

    Histone cluster 2, H2be
    Hs.2178  [show with all ESTs]
    Unigene Representative Sequence: BC069193
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369155(uc001etc.3)

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST2H2BE:
    hsa-miR-146a* hsa-miR-1276 hsa-miR-339-3p hsa-miR-1293 hsa-miR-1207-5p hsa-miR-3647-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: HIST2H2BE 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST2H2BE (see all 4)
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    Clone
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    Additional cDNA sequence: 

    AK093747.1 BC005827.2 BC069193.1 BC096121.2 BC098112.1 BC098289.1 BC107084.1 BC107085.1 
    CR541895.1 M60756.1 

    11 DOTS entries:

    DT.95258191  DT.100773959  DT.447760  DT.100795660  DT.121432886  DT.100795657  DT.100795656  DT.100795662 
    DT.121432792  DT.95274152  DT.97858897 

    24/254 AceView cDNA sequences (see all 254):

    CD617183 CD617176 BE888669 BE791462 AI675687 AI567629 AI866878 BI714827 
    AA011481 CN481705 BM695736 AI680683 AI668859 AA101805 AI291165 AI422586 
    CB133679 F04867 AI290080 CF142073 AA906788 BE218223 BQ924079 AA149649 

    GeneLoc Exon Structure


    Expression
    for HIST2H2BE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H2BE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGTTTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST2H2BE expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST2H2BE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST2H2BE

    SOURCE GeneReport for Unigene cluster: Hs.2178
        SABiosciences Custom PCR Arrays for HIST2H2BE
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2BE

    Orthologs
    for HIST2H2BE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H2BE gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H2B1_CHICK6
    H2B1_CHICK6
    (see all 8)    		 Histone H2B 1/2/3/4/6
    (see all 8)    		 97(a)
    97(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 1(49976548-49976928)
    1(50028609-50028989)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 8)    		 --
    		 95(a)
    95(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 GL343252.1(1811547-1811927)
    GL343466.1(297869-298249)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ618222.12   -- 86.55(n)    BJ618222.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC059463.12   -- 83.63(n)   386920  BC059463.1 
    soybean
    (Glycine max)    		 eudicotyledons 467348742   -- 79.04(n)  
    rice
    (Oryza sativa)    		 Liliopsida Os.477142 Transcribed sequence with moderate similarity to protein more 84.25(n)    BU673208.1 


    ENSEMBL Gene Tree for HIST2H2BE (if available)
    TreeFam Gene Tree for HIST2H2BE (if available) 

    Paralogs
    for HIST2H2BE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H2BE gene
    HIST1H2BE1 2  HIST1H2BF1 2  HIST1H2BC1 2  HIST1H2BI1 2  HIST1H2BG1 2  HIST3H2BB2  HIST1H2BK2  HIST1H2BD2  
    HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BB2  
    18/22 SIMAP similar genes for HIST2H2BE using alignment to 1 protein entry:     H2B2E_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH
    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BM    HIST1H2BN    HIST1H2BO
    HIST2H2BF    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    HIST2H2BC

    HIST2H2BE for paralogs           About GeneDecksing



    Genomic Variants
    for HIST2H2BE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/21 NCBI SNPs in HIST2H2BE are shown (see all 21)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1431594931,2
    		--149855555(+) CTAGGA/CGCTTA 1 -- ds50010--------
    rs1482785941,2
    		--149855723(+) GCTCCA/GTAGGT 1 -- ds50010--------
    rs599566121,2
    		F,--149855734(+) GTTAGC/TTTAAC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs795557581,2
    		C,--149855904(+) ATCCCC/TCAGAT 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1417056091,2
    		--149855907(+) CCCCAC/GATCAG 1 -- ds50010--------
    rs1462523201,2
    		--149855922(+) ACCCAC/TGCTTT 1 -- ds50010--------
    rs168418201,2
    		C,F,H,--149856147(+) CATCAG/ACTCCA 1 -- ut31 ese310Minor allele frequency- A:0.07NA NS WA 1054
    rs1379239841,2
    		--149856334(+) ACCAAC/TGAGGC 1 -- ut310--------
    rs159311,2
    		C,F,H,--149856350(+) TTGGCC/TTCATT 1 -- ut31 ese317Minor allele frequency- T:0.09MN NA NS EA 1714
    rs1873745001,2
    		--149856454(+) CTTTAA/GGAGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HIST2H2BE (149856010 - 149858232 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HIST2H2BE
         3 CNVs: 3313 2326 8329
         1 Inversion: 37081

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    Disorders / Diseases
    for HIST2H2BE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST2H2BE for disorders           About GeneDecksing

    OMIM gene information: 601831    OMIM disorders: --

    15 diseases for HIST2H2BE:    About MalaCards
    connective tissue disease    lymphocytic choriomeningitis    systemic lupus erythematosus    lupus erythematosus
    herpes simplex    hepatitis c    vaccinia    ovarian carcinoma
    colon cancer    influenza    hepatitis    immunodeficiency
    carcinoma    malaria    neuronitis

    1 Novoseek disease relationship for HIST2H2BE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 11812781 (1), 18832071 (1)


    Export disorders for HIST2H2BE gene to outside databases

    Publications
    for HIST2H2BE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H2BE gene, integrated from 9 sources (see all 231):
    (articles sorted by number of sources associating them with HIST2H2BE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PubMed id 1469070)1, 2, 3, 9 Collart D.... Stein G.S. (1992)
    2. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    3. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2, 9 Beck H.C.... Jensen O.N. (2006)
    4. Gene-specific characterization of human histone H2B by electron capture dissociation. (PubMed id 16457587)1, 2, 9 Siuti N.... Pesavento J.J. (2006)
    5. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K7 9 methylation. (PubMed id 21726816)1, 2 Wu L....Dou Y. (2011)
    6. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
    9. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    External Searches for HIST2H2BE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST2H2BE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8349 HGNC: 4760 AceView: HIST2H2BE Ensembl:ENSG00000184678 euGenes: HUgn8349
    ECgene: HIST2H2BE Kegg: 8349 H-InvDB: HIST2H2BE

    Other Databases showing HIST2H2BE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST2H2BE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H2BE Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST2H2BE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST2H2BE gene:
    Search GeneIP for patents involving HIST2H2BE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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