Aliases for HIST2H2BE Gene
Aliases for HIST2H2BE Gene
External Ids for HIST2H2BE Gene
- HGNC: 4760
- Entrez Gene: 8349
- Ensembl: ENSG00000184678
- OMIM: 601831
- UniProtKB: Q16778
Previous HGNC Symbols for HIST2H2BE Gene
- H2B
- H2BFQ
Previous GeneCards Identifiers for HIST2H2BE Gene
- GC01M145598
- GC01M146631
- GC01M147072
- GC01M146669
- GC01M148122
- GC01M148082
- GC01M149856
- GC01M121237
- GC01M149846
Summaries for HIST2H2BE Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST2H2BE Gene
HIST2H2BE (Histone Cluster 2 H2B Family Member E) is a Protein Coding gene. Diseases associated with HIST2H2BE include Vaccinia and Systemic Lupus Erythematosus. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BI.
UniProtKB/Swiss-Prot for HIST2H2BE Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
-
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BE Gene
Genomics for HIST2H2BE Gene
Regulatory Elements for HIST2H2BE Gene
Enhancers for HIST2H2BE Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST2H2BE on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST2H2BE gene promoter:
Regulatory Element Products
Genomic Location for HIST2H2BE Gene
- Chromosome:
- 1
- Start:
- 149,884,459 bp from pter
- End:
- 149,886,682 bp from pter
- Size:
- 2,224 bases
- Orientation:
- Minus strand
Genomic View for HIST2H2BE Gene
Genes around HIST2H2BE on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
HIST2H2BE Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST2H2BE Gene
Proteins for HIST2H2BE Gene
-
Protein details for HIST2H2BE Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16778-H2B2E_HUMAN
- Recommended name:
- Histone H2B type 2-E
- Protein Accession:
- Q16778
- A3KMC7
- A8K110
- Q4KMY1
- Q5QNX0
- Q9UE88
Protein attributes for HIST2H2BE Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13920 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST2H2BE Gene
Post-translational modifications for HIST2H2BE Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- Ubiquitination at posLast=121121
- Glycosylation at isoforms=113
- Modification sites at PhosphoSitePlus
Other Protein References for HIST2H2BE Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST2H2BE
-
Abcam antibodies for HIST2H2BE
-
Cloud-Clone Corp. Antibodies for HIST2H2BE
- Invitrogen Antibodies for HIST2H2BE
- GeneTex HIST2H2BE antibody for HIST2H2BE
Protein Products
-
OriGene Purified Proteins for HIST2H2BE
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-
Cloud-Clone Corp. Proteins for HIST2H2BE
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-
Abcam proteins for HIST2H2BE
Assay Products
No data available for DME Specific Peptides for HIST2H2BE Gene
Domains & Families for HIST2H2BE Gene
Gene Families for HIST2H2BE Gene
- HGNC:
Protein Domains for HIST2H2BE Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST2H2BE Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16778- Family:
-
- Belongs to the histone H2B family.
Function for HIST2H2BE Gene
Molecular function for HIST2H2BE Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- UniProtKB/Swiss-Prot Function:
- Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | 1469070 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST2H2BE Gene
- GenomeRNAi human phenotypes for HIST2H2BE:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H2BE gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST2H2BE gene
- Search ViGene Biosciences for HIST2H2BE
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H2BE
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H2BE
- GenScript: Design CRISPR guide RNA sequences for HIST2H2BE
miRNA for HIST2H2BE Gene
- miRTarBase miRNAs that target HIST2H2BE
-
- hsa-mir-34a-5p (MIRT025415)
- hsa-mir-103a-3p (MIRT027073)
- hsa-mir-16-5p (MIRT031573)
- hsa-mir-877-3p (MIRT037085)
- hsa-mir-423-5p (MIRT038016)
- hsa-mir-296-3p (MIRT038396)
- hsa-mir-615-3p (MIRT040129)
- hsa-let-7a-5p (MIRT052380)
- hsa-mir-760 (MIRT059334)
- hsa-mir-6822-3p (MIRT059341)
- hsa-mir-6792-5p (MIRT557278)
- hsa-mir-6838-5p (MIRT557279)
- hsa-mir-497-5p (MIRT557280)
- hsa-mir-424-5p (MIRT557281)
- hsa-mir-195-5p (MIRT557282)
- hsa-mir-15b-5p (MIRT557283)
- hsa-mir-15a-5p (MIRT557284)
- hsa-mir-7161-5p (MIRT557285)
- hsa-mir-548u (MIRT557286)
- hsa-mir-5693 (MIRT557287)
- hsa-mir-8057 (MIRT557288)
- hsa-mir-4309 (MIRT557289)
- hsa-mir-3198 (MIRT557290)
- hsa-mir-6802-5p (MIRT557291)
- hsa-mir-6748-5p (MIRT557292)
- hsa-mir-6769b-5p (MIRT557293)
- hsa-mir-6769a-5p (MIRT557294)
- hsa-mir-4483 (MIRT557295)
- hsa-mir-1293 (MIRT557296)
- hsa-mir-6766-5p (MIRT557297)
- hsa-mir-6756-5p (MIRT557298)
- hsa-mir-6745 (MIRT557299)
- hsa-mir-363-5p (MIRT557300)
- hsa-mir-4294 (MIRT557301)
- hsa-mir-1289 (MIRT557302)
- hsa-mir-4766-5p (MIRT557303)
- hsa-mir-146a-3p (MIRT557304)
- hsa-mir-6865-5p (MIRT557305)
- hsa-mir-6815-5p (MIRT557306)
- hsa-mir-1276 (MIRT557307)
miRNA Products
- Search ViGene Biosciences for HIST2H2BE
Inhibitory RNA Products
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Clone Products
-
OriGene ORF clones in human for HIST2H2BE
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST2H2BE
Cell Line Products
-
Horizon Cell Lines for HIST2H2BE
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST2H2BE gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H2BE gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST2H2BE gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2BE Gene
Localization for HIST2H2BE Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BE Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | NAS | 1469070 |
| GO:0005615 | extracellular space | IDA | 12860195 |
| GO:0005634 | nucleus | IEA,IDA | 16319397 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HIST2H2BE Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST2H2BE Gene
1 GeneTex pathway for HIST2H2BE Gene
66 Reactome pathways for HIST2H2BE Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST2H2BE Gene
1 GeneGo (Thomson Reuters) pathway for HIST2H2BE Gene
Interacting Proteins for HIST2H2BE Gene
Selected Interacting proteins:
Q16778-H2B2E_HUMAN
ENSP00000358151
for HIST2H2BE Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
| GO:0006334 | nucleosome assembly | NAS | 1469070 |
| GO:0019731 | antibacterial humoral response | IDA | 12860195 |
| GO:0042742 | defense response to bacterium | IEA | -- |
| GO:0050830 | defense response to Gram-positive bacterium | IDA | 12860195 |
No data available for SIGNOR curated interactions for HIST2H2BE Gene
Transcripts for HIST2H2BE Gene
mRNA/cDNA for HIST2H2BE Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (254) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST2H2BE Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H2BE
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H2BE
- GenScript: Design CRISPR guide RNA sequences for HIST2H2BE
miRNA Products
- Search ViGene Biosciences for HIST2H2BE
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST2H2BE
- Browse OriGene Inhibitory RNA Products For HIST2H2BE
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST2H2BE gene
Clone Products
-
OriGene ORF clones in human for HIST2H2BE
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST2H2BE
Flow Cytometry Products
Expression for HIST2H2BE Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
mRNA differential expression in normal tissues according to GTEx for HIST2H2BE Gene
This gene is overexpressed in Whole Blood (x5.8).
This gene is overexpressed in Saliva (53.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST2H2BE Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST2H2BE Gene:
HIST2H2BESOURCE GeneReport for Unigene cluster for HIST2H2BE Gene:
Hs.2178Evidence on tissue expression from TISSUES for HIST2H2BE Gene
- Nervous system(4.9)
- Blood(4.7)
- Liver(4.5)
- Lung(4.5)
- Spleen(3.3)
- Bone marrow(2.8)
- Heart(2.5)
- Skin(2.5)
- Lymph node(2.4)
- Pancreas(2.2)
- Kidney(2.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for HIST2H2BE
-
OriGene qPCR primer pairs for HIST2H2BE
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2BE Gene
Orthologs for HIST2H2BE Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | HIST2H2BE 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIST2H2BE 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | HIST2H2BE 35 |
|
OneToOne | |
| HIST1H2BD 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | H2B 35 |
|
ManyToMany | |
| LOC512612 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | LOC483170 34 |
|
||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | H2B-I 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1950 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:194989 35 |
|
ManyToMany | |
| wu:fe11b02 35 35 35 35 35 35 35 35 |
|
ManyToMany | |||
| ano9a 35 35 |
|
ManyToMany | |||
| zgc:171759 35 35 35 35 35 35 35 35 35 35 |
|
ManyToMany | |||
| si:dkey-261m9.19 35 |
|
ManyToMany | |||
| si:dkey-261m9.6 35 |
|
ManyToMany | |||
| zgc:112234 35 35 35 35 35 |
|
ManyToMany | |||
| zgc:173587 35 |
|
ManyToMany | |||
| CABZ01086354.1 35 |
|
ManyToMany | |||
| LOC560748 34 |
|
||||
| -- 34 |
|
||||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.11306 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.47714 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.27708 34 |
|
- Species where no ortholog for HIST2H2BE was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- worm (Caenorhabditis elegans)
Paralogs for HIST2H2BE Gene
Paralogs for HIST2H2BE Gene
(23) SIMAP similar genes for HIST2H2BE Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HIST2H2BE Gene
Variants for HIST2H2BE Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002085119 | -- | 149,885,572(+) | AATGA(A/G)AAATA | upstream-variant-2KB, utr-variant-3-prime | |
| rs1004208294 | -- | 149,886,803(+) | AACAA(C/T)ACCGA | upstream-variant-2KB | |
| rs1005621517 | -- | 149,885,489(+) | ACATG(C/G)TAAGT | upstream-variant-2KB, utr-variant-3-prime | |
| rs1008980388 | -- | 149,887,855(+) | CAGCG(C/T)GGGAC | downstream-variant-500B, upstream-variant-2KB, reference, missense | |
| rs1010395410 | -- | 149,884,201(+) | ATGAA(C/T)TTTAT | downstream-variant-500B |
Residual Variation Intolerance Score:
48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.23;
5.09% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST2H2BE Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST2H2BE
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H2BE Gene
Disorders for HIST2H2BE Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vaccinia |
|
|
| systemic lupus erythematosus |
|
|
| connective tissue disease |
|
|
| mixed germ cell cancer |
|
|
| retinitis pigmentosa 20 |
|
|
Search HIST2H2BE in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HIST2H2BE
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST2H2BE
No data available for UniProtKB/Swiss-Prot and Genatlas for HIST2H2BE Gene
Publications for HIST2H2BE Gene
- A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PMID: 1469070) Collart D. … Stein G.S. (J. Cell. Biochem. 1992) 2 3 4 22 64
- Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 4 22 64
- Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N. … Pesavento J.J. (J. Proteome Res. 2006) 3 4 22 64
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PMID: 23824326) Zhang Z. … Wang H. (Genes Dev. 2013) 3 4 64
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HIST2H2BE
- Abcam proteins for HIST2H2BE
- Search for Assays for HIST2H2BE at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for HIST2H2BE
- Cloud-Clone Corp. Proteins for HIST2H2BE
- Browse Assay Kits at Cloud-Clone Corp.
- Invitrogen Antibodies for HIST2H2BE
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST2H2BE
- GeneTex HIST2H2BE antibody for HIST2H2BE
- Search GeneTex for Proteins for HIST2H2BE
- ViGene Biosciences adenoviral particle packaged cDNA for HIST2H2BE gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST2H2BE gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIST2H2BE gene
- Search ViGene Biosciences for HIST2H2BE
- Search Santa Cruz Biotechnology (SCBT) for HIST2H2BE Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST2H2BE siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H2BE
- Horizon Cell Lines for HIST2H2BE
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST2H2BE
- VectorBuilder custom plasmid, inducible vectors for HIST2H2BE
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST2H2BE
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST2H2BE Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer