Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST2H2BD Gene

Subcategory (RNA class) for HIST2H2BD Gene

lncRNA

Aliases for HIST2H2BD Gene

  • Histone Cluster 2, H2bd (Pseudogene) 2 3
  • H2B Histone Family, Member O 2 3
  • Histone 2, H2bd 2 3
  • H2B/S 3
  • H2B/O 3
  • H2BFO 3

External Ids for HIST2H2BD Gene

ORGUL Members for HIST2H2BD Gene

Previous Symbols for HIST2H2BD Gene

  • H2BFO

Summaries for HIST2H2BD Gene

GeneCards Summary for HIST2H2BD Gene

HIST2H2BD (Histone Cluster 2, H2bd (Pseudogene)) is a Pseudogene, and belongs to lncRNA RNA class. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for HIST2H2BD Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

fRNAdb sequence ontologies for HIST2H2BD Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for HIST2H2BD

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for HIST2H2BD Gene

Genomics for HIST2H2BD Gene

Genomic Location for HIST2H2BD Gene

Start:
149,843,020 bp from pter
End:
149,843,533 bp from pter
Size:
514 bases
Orientation:
Plus strand

Genomic View for HIST2H2BD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST2H2BD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BD Gene

ORGUL Member Location for HIST2H2BD Gene

ORGUL Member Location for HIST2H2BD gene

No data available for Regulatory Elements for HIST2H2BD Gene

Proteins for HIST2H2BD Gene

  • Protein details for HIST2H2BD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DRA6-H2B2D_HUMAN
    Recommended name:
    Putative histone H2B type 2-D
    Protein Accession:
    Q6DRA6
    Secondary Accessions:

    Protein attributes for HIST2H2BD Gene

    Size:
    164 amino acids
    Molecular mass:
    18018 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    Miscellaneous:
    • The mouse orthologous protein seems not to exist

neXtProt entry for HIST2H2BD Gene

Proteomics data for HIST2H2BD Gene at MOPED

Post-translational modifications for HIST2H2BD Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HIST2H2BD Gene

Domains for HIST2H2BD Gene

Gene Families for HIST2H2BD Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST2H2BD Gene

UniProtKB/Swiss-Prot:

H2B2D_HUMAN
Family:
  • Belongs to the histone H2B family.:
    • Q6DRA6
genes like me logo Genes that share domains with HIST2H2BD: view

Function for HIST2H2BD Gene

Molecular function for HIST2H2BD Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST2H2BD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H2BD: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HIST2H2BD Gene

Localization for HIST2H2BD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BD Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for HIST2H2BD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HIST2H2BD: view

Pathways for HIST2H2BD Gene

SuperPathways for HIST2H2BD Gene

No Data Available

Interacting Proteins for HIST2H2BD Gene

Gene Ontology (GO) - Biological Process for HIST2H2BD Gene

None

No data available for Pathways by source for HIST2H2BD Gene

Transcripts for HIST2H2BD Gene

fRNAdb Secondary structures for HIST2H2BD Gene

  • FR083303

mRNA/cDNA for HIST2H2BD Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BD Gene

No ASD Table

Relevant External Links for HIST2H2BD Gene

GeneLoc Exon Structure for
HIST2H2BD
ECgene alternative splicing isoforms for
HIST2H2BD

Expression for HIST2H2BD Gene

mRNA expression in normal human tissues for HIST2H2BD Gene

genes like me logo Genes that share expressions with HIST2H2BD: view

Orthologs for HIST2H2BD Gene

Evolution for HIST2H2BD Gene

ENSEMBL:
Gene Tree for HIST2H2BD (if available)
TreeFam:
Gene Tree for HIST2H2BD (if available)

No data available for Orthologs for HIST2H2BD Gene

Paralogs for HIST2H2BD Gene

genes like me logo Genes that share paralogs with HIST2H2BD: view

No data available for Paralogs for HIST2H2BD Gene

Variants for HIST2H2BD Gene

Relevant External Links for HIST2H2BD Gene

HapMap Linkage Disequilibrium report
HIST2H2BD

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BD Gene

Disorders for HIST2H2BD Gene

No disorders were found for HIST2H2BD Gene.

No data available for UniProtKB/Swiss-Prot for HIST2H2BD Gene

Publications for HIST2H2BD Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4
  4. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4
  5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PMID: 16916647) Kim S.C. … Zhao Y. (Mol. Cell 2006) 3

Products for HIST2H2BD Gene

Sources for HIST2H2BD Gene

Back to Top

Content