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Aliases for HIST2H2BC Gene

Aliases for HIST2H2BC Gene

  • Histone Cluster 2 H2B Family Member C (Pseudogene) 2 3 5
  • Histone Cluster 2, H2bc (Pseudogene) 2 3
  • Histone 2, H2bc 2 3
  • H2B/T 3 4
  • Histone Cluster 2, H2bc 2
  • Histone H2B/S 3
  • Histone H2B.T 4
  • HIST2H2BD 3

External Ids for HIST2H2BC Gene

Previous GeneCards Identifiers for HIST2H2BC Gene

  • GC01U900036
  • GC01M147038
  • GC01M146635
  • GC01M148089
  • GC01M148090
  • GC01M148091
  • GC01M149821
  • GC01P121197
  • GC01M149852
  • GC01M149858
  • GC01M149862
  • GC01M149863

Summaries for HIST2H2BC Gene

Entrez Gene Summary for HIST2H2BC Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for HIST2H2BC Gene

HIST2H2BC (Histone Cluster 2 H2B Family Member C (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for HIST2H2BC Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Additional gene information for HIST2H2BC Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BC Gene

Genomics for HIST2H2BC Gene

Regulatory Elements for HIST2H2BC Gene

Enhancers for HIST2H2BC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H149883 1.4 ENCODE dbSUPER 27 -35.9 -35930 5.9 MLX ZFP64 FEZF1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 PRPF3 SF3B4 ARNT UBE2D3P3 RPRD2 GOLPH3L HIST2H2BD CTSK SV2A HIST2H2BC
GH01H149156 2 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +690.4 690437 7.8 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 LOC647481 SF3B4 HIST2H2BD HIST2H2AB LOC101927468 HIST2H2BC VPS45 ENSG00000261716 PDE4DIP GC01M149164
GH01H148887 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +957.9 957927 10.5 HDGF PKNOX1 FOXA2 DMAP1 YY1 ZNF143 FOS DEK REST SREBF1 LOC647481 GPR89B HIST2H2BD HIST2H2BC PDE4DIP ENSG00000261716 GC01M148879 RNU2-38P
GH01H150232 1.4 ENCODE dbSUPER 18.6 -384.4 -384364 4.8 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN SETDB1 PRPF3 GABPB2 PIP5K1A SF3B4 RPRD2 ARNT UBE2D3P3 GOLPH3L HIST2H2BD
GH01H150486 1.2 ENCODE 18.6 -636.9 -636867 1.7 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SETDB1 PIP5K1A PRPF3 SF3B4 ZNF687 GABPB2 PI4KB GOLPH3L ARNT UBE2D3P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST2H2BC on UCSC Golden Path with GeneCards custom track

Genomic Locations for HIST2H2BC Gene

Genomic Locations for HIST2H2BC Gene
chr1:149,850,192-149,850,773
(GRCh38/hg38)
Size:
582 bases
Orientation:
Minus strand
chr1:149,821,759-149,822,340
(GRCh37/hg19)

Genomic View for HIST2H2BC Gene

Genes around HIST2H2BC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H2BC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H2BC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BC Gene

Proteins for HIST2H2BC Gene

  • Protein details for HIST2H2BC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DN03-H2B2C_HUMAN
    Recommended name:
    Putative histone H2B type 2-C
    Protein Accession:
    Q6DN03
    Secondary Accessions:
    • B7Z677

    Protein attributes for HIST2H2BC Gene

    Size:
    193 amino acids
    Molecular mass:
    21472 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    Miscellaneous:
    • The mouse orthologous protein seems not to exist.

neXtProt entry for HIST2H2BC Gene

Post-translational modifications for HIST2H2BC Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HIST2H2BC Gene

Domains & Families for HIST2H2BC Gene

Gene Families for HIST2H2BC Gene

Protein Domains for HIST2H2BC Gene

Suggested Antigen Peptide Sequences for HIST2H2BC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6DN03

UniProtKB/Swiss-Prot:

H2B2C_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BC: view

Function for HIST2H2BC Gene

Molecular function for HIST2H2BC Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes for HIST2H2BC Gene

GenomeRNAi human phenotypes for HIST2H2BC:
genes like me logo Genes that share phenotypes with HIST2H2BC: view

Animal Model Products

miRNA for HIST2H2BC Gene

miRTarBase miRNAs that target HIST2H2BC

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2BC Gene

Localization for HIST2H2BC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BC Gene

Nucleus. Chromosome.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HIST2H2BC Gene

Pathways & Interactions for HIST2H2BC Gene

SuperPathways for HIST2H2BC Gene

No Data Available

Interacting Proteins for HIST2H2BC Gene

Selected Interacting proteins: Q6DN03-H2B2C_HUMAN for HIST2H2BC Gene via IID

Symbol External ID(s) Details
JUN

Gene Ontology (GO) - Biological Process for HIST2H2BC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HIST2H2BC Gene

Drugs & Compounds for HIST2H2BC Gene

No Compound Related Data Available

Transcripts for HIST2H2BC Gene

mRNA/cDNA for HIST2H2BC Gene

(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2BC Gene

Histone cluster 2, H2bc (pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BC Gene

No ASD Table

Relevant External Links for HIST2H2BC Gene

GeneLoc Exon Structure for
HIST2H2BC
ECgene alternative splicing isoforms for
HIST2H2BC

Expression for HIST2H2BC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H2BC Gene

mRNA differential expression in normal tissues according to GTEx for HIST2H2BC Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for HIST2H2BC Gene

This gene is overexpressed in Pancreas (31.0), Monocytes (20.3), Blymphocyte (9.3), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST2H2BC Gene



Protein tissue co-expression partners for HIST2H2BC Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST2H2BC Gene:

HIST2H2BC

SOURCE GeneReport for Unigene cluster for HIST2H2BC Gene:

Hs.666643
genes like me logo Genes that share expression patterns with HIST2H2BC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2BC Gene

Orthologs for HIST2H2BC Gene

Evolution for HIST2H2BC Gene

ENSEMBL:
Gene Tree for HIST2H2BC (if available)
TreeFam:
Gene Tree for HIST2H2BC (if available)

No data available for Orthologs for HIST2H2BC Gene

Paralogs for HIST2H2BC Gene

genes like me logo Genes that share paralogs with HIST2H2BC: view

No data available for Paralogs for HIST2H2BC Gene

Variants for HIST2H2BC Gene

Sequence variations from dbSNP and Humsavar for HIST2H2BC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1009565784 -- 149,849,706(+) GATTT(G/T)AGGGT downstream-variant-500B, upstream-variant-2KB
rs1013070338 -- 149,850,237(+) AGACG(C/T)GAAGC nc-transcript-variant, upstream-variant-2KB
rs1013085481 -- 149,850,002(+) ACTTA(C/T)CAAAA downstream-variant-500B, upstream-variant-2KB
rs1015153667 -- 149,849,708(+) TTTTA(C/G)GGTAT downstream-variant-500B, upstream-variant-2KB
rs1024496342 -- 149,850,255(+) ATCAA(A/C)TGGGA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BC Gene

Variant ID Type Subtype PubMed ID
nsv946381 CNV duplication 23825009
nsv831525 CNV gain 17160897
nsv7182 OTHER inversion 18451855
nsv499132 OTHER inversion 21111241
nsv469694 CNV loss 16826518
nsv46 OTHER inversion 15895083
esv1007634 OTHER inversion 20482838

Relevant External Links for HIST2H2BC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST2H2BC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H2BC Gene

Disorders for HIST2H2BC Gene

Relevant External Links for HIST2H2BC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST2H2BC

No disorders were found for HIST2H2BC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2BC Gene

Publications for HIST2H2BC Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad CD … Stein GS (Gene 2004) 2 3 4 60
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 60
  3. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F … Kasprzak KS (Molecular and cellular biochemistry 2005) 3 4 60
  4. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung WL … Allis CD (Cell 2003) 3 4 60
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for HIST2H2BC Gene

Sources for HIST2H2BC Gene

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