Aliases for HIST2H2BC Gene
External Ids for HIST2H2BC Gene
Previous GeneCards Identifiers for HIST2H2BC Gene
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]
GeneCards Summary for HIST2H2BC Gene
HIST2H2BC (Histone Cluster 2, H2bc (Pseudogene)) is a Pseudogene.
UniProtKB/Swiss-Prot for HIST2H2BC Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.