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Aliases for HIST2H2BC Gene

Aliases for HIST2H2BC Gene

  • Histone Cluster 2, H2bc (Pseudogene) 2 3
  • Histone 2, H2bc 2 3
  • H2B/T 3 4
  • Histone Cluster 2, H2bc 2
  • Histone H2B/S 3
  • Histone H2B.T 4
  • HIST2H2BD 3

External Ids for HIST2H2BC Gene

Previous GeneCards Identifiers for HIST2H2BC Gene

  • GC01U900036
  • GC01M147038
  • GC01M146635
  • GC01M148089
  • GC01M148090
  • GC01M148091
  • GC01M149821
  • GC01P121197

Summaries for HIST2H2BC Gene

Entrez Gene Summary for HIST2H2BC Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for HIST2H2BC Gene

HIST2H2BC (Histone Cluster 2, H2bc (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for HIST2H2BC Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BC Gene

Genomics for HIST2H2BC Gene

Genomic Location for HIST2H2BC Gene

Chromosome:
1
Start:
149,850,192 bp from pter
End:
149,850,773 bp from pter
Size:
582 bases
Orientation:
Minus strand

Genomic View for HIST2H2BC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST2H2BC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BC Gene

No data available for Regulatory Elements for HIST2H2BC Gene

Proteins for HIST2H2BC Gene

  • Protein details for HIST2H2BC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DN03-H2B2C_HUMAN
    Recommended name:
    Putative histone H2B type 2-C
    Protein Accession:
    Q6DN03
    Secondary Accessions:
    • B7Z677

    Protein attributes for HIST2H2BC Gene

    Size:
    193 amino acids
    Molecular mass:
    21472 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    Miscellaneous:
    • The mouse orthologous protein seems not to exist

neXtProt entry for HIST2H2BC Gene

Proteomics data for HIST2H2BC Gene at MOPED

Post-translational modifications for HIST2H2BC Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HIST2H2BC Gene

Domains & Families for HIST2H2BC Gene

Gene Families for HIST2H2BC Gene

HGNC:

Protein Domains for HIST2H2BC Gene

Suggested Antigen Peptide Sequences for HIST2H2BC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6DN03

UniProtKB/Swiss-Prot:

H2B2C_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BC: view

Function for HIST2H2BC Gene

Molecular function for HIST2H2BC Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Phenotypes for HIST2H2BC Gene

GenomeRNAi human phenotypes for HIST2H2BC:
genes like me logo Genes that share phenotypes with HIST2H2BC: view

miRNA for HIST2H2BC Gene

miRTarBase miRNAs that target HIST2H2BC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2BC Gene

Localization for HIST2H2BC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BC Gene

Nucleus. Chromosome.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HIST2H2BC Gene

Pathways & Interactions for HIST2H2BC Gene

SuperPathways for HIST2H2BC Gene

No Data Available

Interacting Proteins for HIST2H2BC Gene

Gene Ontology (GO) - Biological Process for HIST2H2BC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HIST2H2BC Gene

Drugs & Compounds for HIST2H2BC Gene

No Compound Related Data Available

Transcripts for HIST2H2BC Gene

mRNA/cDNA for HIST2H2BC Gene

(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2BC Gene

Histone cluster 2, H2bc (pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BC Gene

No ASD Table

Relevant External Links for HIST2H2BC Gene

GeneLoc Exon Structure for
HIST2H2BC
ECgene alternative splicing isoforms for
HIST2H2BC

Expression for HIST2H2BC Gene

mRNA expression in normal human tissues for HIST2H2BC Gene

mRNA differential expression in normal tissues according to GTEx for HIST2H2BC Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for HIST2H2BC Gene

This gene is overexpressed in Pancreas (31.0), Monocytes (20.3), Blymphocyte (9.3), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HIST2H2BC Gene



SOURCE GeneReport for Unigene cluster for HIST2H2BC Gene Hs.666643

genes like me logo Genes that share expression patterns with HIST2H2BC: view

Protein tissue co-expression partners for HIST2H2BC Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST2H2BC Gene

Orthologs for HIST2H2BC Gene

Evolution for HIST2H2BC Gene

ENSEMBL:
Gene Tree for HIST2H2BC (if available)
TreeFam:
Gene Tree for HIST2H2BC (if available)

No data available for Orthologs for HIST2H2BC Gene

Paralogs for HIST2H2BC Gene

genes like me logo Genes that share paralogs with HIST2H2BC: view

No data available for Paralogs for HIST2H2BC Gene

Variants for HIST2H2BC Gene

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BC Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv469694 CNV Loss 16826518
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
esv1007634 OTHER Inversion 20482838
nsv7182 OTHER Inversion 18451855
nsv499132 OTHER Inversion 21111241
nsv46 OTHER Inversion 15895083

Relevant External Links for HIST2H2BC Gene

HapMap Linkage Disequilibrium report
HIST2H2BC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for HIST2H2BC Gene

Disorders for HIST2H2BC Gene

Relevant External Links for HIST2H2BC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST2H2BC
genes like me logo Genes that share disorders with HIST2H2BC: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2BC Gene

Publications for HIST2H2BC Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 67
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 67
  3. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PMID: 21925322) Tan M. … Zhao Y. (Cell 2011) 67
  4. Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line. (PMID: 20194426) GonzA!lez-Romero R. … EirA-n-LA^pez J.M. (Mol. Biol. Evol. 2010) 67
  5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PMID: 16916647) Kim S.C. … Zhao Y. (Mol. Cell 2006) 67

Products for HIST2H2BC Gene

Sources for HIST2H2BC Gene

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