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Aliases for HIST2H2BC Gene

Aliases for HIST2H2BC Gene

  • Histone Cluster 2, H2bc (Pseudogene) 2 3
  • Histone 2, H2bc 2 3
  • H2B/T 3 4
  • Histone Cluster 2, H2bc 2
  • Histone H2B/S 3
  • Histone H2B.T 4
  • HIST2H2BD 3

External Ids for HIST2H2BC Gene

Previous GeneCards Identifiers for HIST2H2BC Gene

  • GC01U900036
  • GC01M147038
  • GC01M146635
  • GC01M148089
  • GC01M148090
  • GC01M148091
  • GC01M149821
  • GC01P121197

Summaries for HIST2H2BC Gene

GeneCards Summary for HIST2H2BC Gene

HIST2H2BC (Histone Cluster 2, H2bc (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for HIST2H2BC Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BC Gene

Genomics for HIST2H2BC Gene

Genomic Location for HIST2H2BC Gene

Start:
149,850,192 bp from pter
End:
149,850,773 bp from pter
Size:
582 bases
Orientation:
Minus strand

Genomic View for HIST2H2BC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST2H2BC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BC Gene

No data available for Regulatory Elements for HIST2H2BC Gene

Proteins for HIST2H2BC Gene

  • Protein details for HIST2H2BC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DN03-H2B2C_HUMAN
    Recommended name:
    Putative histone H2B type 2-C
    Protein Accession:
    Q6DN03
    Secondary Accessions:
    • B7Z677

    Protein attributes for HIST2H2BC Gene

    Size:
    193 amino acids
    Molecular mass:
    21472 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    Miscellaneous:
    • The mouse orthologous protein seems not to exist

neXtProt entry for HIST2H2BC Gene

Proteomics data for HIST2H2BC Gene at MOPED

Post-translational modifications for HIST2H2BC Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HIST2H2BC Gene

Domains for HIST2H2BC Gene

Gene Families for HIST2H2BC Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST2H2BC Gene

Suggested Antigen Peptide Sequences for HIST2H2BC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6DN03

UniProtKB/Swiss-Prot:

H2B2C_HUMAN :
  • Q6DN03
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BC: view

Function for HIST2H2BC Gene

Molecular function for HIST2H2BC Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Animal Model Products

miRNA for HIST2H2BC Gene

miRTarBase miRNAs that target HIST2H2BC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST2H2BC Gene

Localization for HIST2H2BC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BC Gene

Nucleus. Chromosome.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HIST2H2BC Gene

Pathways for HIST2H2BC Gene

SuperPathways for HIST2H2BC Gene

No Data Available

Interacting Proteins for HIST2H2BC Gene

Gene Ontology (GO) - Biological Process for HIST2H2BC Gene

None

No data available for Pathways by source for HIST2H2BC Gene

Transcripts for HIST2H2BC Gene

mRNA/cDNA for HIST2H2BC Gene

(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2BC Gene

Histone cluster 2, H2bc (pseudogene):
Representative Sequences:

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST2H2BC
    • Block miRNA regulation of HIST2H2BC using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H2BC

    Primer Products

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BC Gene

    No ASD Table

    Relevant External Links for HIST2H2BC Gene

    GeneLoc Exon Structure for
    HIST2H2BC
    ECgene alternative splicing isoforms for
    HIST2H2BC

    Expression for HIST2H2BC Gene

    mRNA expression in normal human tissues for HIST2H2BC Gene

    mRNA differential expression in normal tissues according to GTEx for HIST2H2BC Gene

    This gene is overexpressed in Whole Blood (5.7).

    Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HIST2H2BC Gene

    SOURCE GeneReport for Unigene cluster for HIST2H2BC Gene Hs.666643

    genes like me logo Genes that share expressions with HIST2H2BC: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST2H2BC Gene

    Orthologs for HIST2H2BC Gene

    Evolution for HIST2H2BC Gene

    ENSEMBL:
    Gene Tree for HIST2H2BC (if available)
    TreeFam:
    Gene Tree for HIST2H2BC (if available)

    No data available for Orthologs for HIST2H2BC Gene

    Paralogs for HIST2H2BC Gene

    genes like me logo Genes that share paralogs with HIST2H2BC: view

    No data available for Paralogs for HIST2H2BC Gene

    Variants for HIST2H2BC Gene

    Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BC Gene

    Variant ID Type Subtype PubMed ID
    dgv117e1 CNV Complex 17122850
    nsv428235 CNV Gain 18775914
    esv2750807 CNV Gain 17911159
    dgv123e1 CNV Complex 17122850
    dgv125e1 CNV Complex 17122850
    nsv469694 CNV Loss 16826518
    nsv831525 CNV Gain 17160897
    essv23032 CNV CNV 17122850
    esv1007634 OTHER Inversion 20482838
    nsv7182 OTHER Inversion 18451855
    nsv499132 OTHER Inversion 21111241
    nsv46 OTHER Inversion 15895083

    Relevant External Links for HIST2H2BC Gene

    HapMap Linkage Disequilibrium report
    HIST2H2BC

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HIST2H2BC Gene

    Disorders for HIST2H2BC Gene

    No disorders were found for HIST2H2BC Gene.

    No data available for UniProtKB/Swiss-Prot for HIST2H2BC Gene

    Publications for HIST2H2BC Gene

    1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 3 4
    2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
    3. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4
    4. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4
    5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PMID: 16916647) Kim S.C. … Zhao Y. (Mol. Cell 2006) 3

    Products for HIST2H2BC Gene

    Sources for HIST2H2BC Gene

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