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Aliases for HIST2H2BC Gene

Aliases for HIST2H2BC Gene

  • Histone Cluster 2 H2B Family Member C (Pseudogene) 2 3 5
  • Histone Cluster 2, H2bc (Pseudogene) 2 3
  • Histone 2, H2bc 2 3
  • H2B/T 3 4
  • Histone Cluster 2, H2bc 2
  • Histone H2B/S 3
  • Histone H2B.T 4
  • HIST2H2BD 3

External Ids for HIST2H2BC Gene

Previous GeneCards Identifiers for HIST2H2BC Gene

  • GC01U900036
  • GC01M147038
  • GC01M146635
  • GC01M148089
  • GC01M148090
  • GC01M148091
  • GC01M149821
  • GC01P121197
  • GC01M149852
  • GC01M149858
  • GC01M149862

Summaries for HIST2H2BC Gene

Entrez Gene Summary for HIST2H2BC Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for HIST2H2BC Gene

HIST2H2BC (Histone Cluster 2 H2B Family Member C (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for HIST2H2BC Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BC Gene

Genomics for HIST2H2BC Gene

Regulatory Elements for HIST2H2BC Gene

Enhancers for HIST2H2BC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G149156 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +690.4 690437 7.8 MLX ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF548 NFYC TBX21 PPARGC1A LOC647481 SF3B4 LOC101927468 HIST2H2BD HIST2H2BC ENSG00000261716 ENSG00000272824 HIST2H2AB SV2A PDE4DIP
GH01G148887 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +957.9 957927 10.5 HDGF PKNOX1 FOXA2 WRNIP1 DMAP1 YY1 ZNF143 FOS DEK REST PDE4DIP HIST2H2BD HIST2H2BC ENSG00000261716 GC01M148879 RNU2-38P
GH01G148859 1 ENCODE dbSUPER 19.2 +991.1 991113 0.2 ZNF777 ZSCAN18 ZBTB21 ZSCAN4 ZEB1 ZBTB48 ZNF169 ZNF350 FOS ZNF362 HIST2H2BD HIST2H2BC LOC647481 LOC101927468 ENSG00000261716 ENSG00000227700 RN7SKP88 GC01M148879
GH01G149883 1.4 ENCODE dbSUPER 10.8 -35.9 -35930 5.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC PRPF3 SV2A SF3B4 UBE2D3P3 ADAMTSL4 VPS45 HIST2H2BD GOLPH3L HIST2H2BC ENSG00000261716
GH01G150232 1.4 ENCODE dbSUPER 10.6 -384.4 -384364 4.8 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ZNF610 SETDB1 GABPB2 PRPF3 ADAMTSL4 GOLPH3L HIST2H2BD HIST2H2BC ENSG00000261716 SF3B4 MCL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST2H2BC on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST2H2BC Gene

Chromosome:
1
Start:
149,850,192 bp from pter
End:
149,850,773 bp from pter
Size:
582 bases
Orientation:
Minus strand

Genomic View for HIST2H2BC Gene

Genes around HIST2H2BC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H2BC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H2BC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BC Gene

Proteins for HIST2H2BC Gene

  • Protein details for HIST2H2BC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DN03-H2B2C_HUMAN
    Recommended name:
    Putative histone H2B type 2-C
    Protein Accession:
    Q6DN03
    Secondary Accessions:
    • B7Z677

    Protein attributes for HIST2H2BC Gene

    Size:
    193 amino acids
    Molecular mass:
    21472 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    Miscellaneous:
    • The mouse orthologous protein seems not to exist.

neXtProt entry for HIST2H2BC Gene

Post-translational modifications for HIST2H2BC Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HIST2H2BC Gene

Domains & Families for HIST2H2BC Gene

Gene Families for HIST2H2BC Gene

Protein Domains for HIST2H2BC Gene

Suggested Antigen Peptide Sequences for HIST2H2BC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6DN03

UniProtKB/Swiss-Prot:

H2B2C_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BC: view

Function for HIST2H2BC Gene

Molecular function for HIST2H2BC Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes for HIST2H2BC Gene

GenomeRNAi human phenotypes for HIST2H2BC:
genes like me logo Genes that share phenotypes with HIST2H2BC: view

Animal Model Products

miRNA for HIST2H2BC Gene

miRTarBase miRNAs that target HIST2H2BC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2BC Gene

Localization for HIST2H2BC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BC Gene

Nucleus. Chromosome.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HIST2H2BC Gene

Pathways & Interactions for HIST2H2BC Gene

SuperPathways for HIST2H2BC Gene

No Data Available

Interacting Proteins for HIST2H2BC Gene

Selected Interacting proteins: Q6DN03-H2B2C_HUMAN for HIST2H2BC Gene via IID

Symbol External ID(s) Details
JUN

Gene Ontology (GO) - Biological Process for HIST2H2BC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HIST2H2BC Gene

Drugs & Compounds for HIST2H2BC Gene

No Compound Related Data Available

Transcripts for HIST2H2BC Gene

mRNA/cDNA for HIST2H2BC Gene

(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2BC Gene

Histone cluster 2, H2bc (pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BC Gene

No ASD Table

Relevant External Links for HIST2H2BC Gene

GeneLoc Exon Structure for
HIST2H2BC
ECgene alternative splicing isoforms for
HIST2H2BC

Expression for HIST2H2BC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H2BC Gene

mRNA differential expression in normal tissues according to GTEx for HIST2H2BC Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for HIST2H2BC Gene

This gene is overexpressed in Pancreas (31.0), Monocytes (20.3), Blymphocyte (9.3), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST2H2BC Gene



Protein tissue co-expression partners for HIST2H2BC Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST2H2BC Gene:

HIST2H2BC

SOURCE GeneReport for Unigene cluster for HIST2H2BC Gene:

Hs.666643
genes like me logo Genes that share expression patterns with HIST2H2BC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2BC Gene

Orthologs for HIST2H2BC Gene

Evolution for HIST2H2BC Gene

ENSEMBL:
Gene Tree for HIST2H2BC (if available)
TreeFam:
Gene Tree for HIST2H2BC (if available)

No data available for Orthologs for HIST2H2BC Gene

Paralogs for HIST2H2BC Gene

genes like me logo Genes that share paralogs with HIST2H2BC: view

No data available for Paralogs for HIST2H2BC Gene

Variants for HIST2H2BC Gene

Sequence variations from dbSNP and Humsavar for HIST2H2BC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1009565784 -- 149,849,706(+) GATTT(G/T)AGGGT downstream-variant-500B, upstream-variant-2KB
rs1013070338 -- 149,850,237(+) AGACG(C/T)GAAGC nc-transcript-variant, upstream-variant-2KB
rs1013085481 -- 149,850,002(+) ACTTA(C/T)CAAAA downstream-variant-500B, upstream-variant-2KB
rs1015153667 -- 149,849,708(+) TTTTA(C/G)GGTAT downstream-variant-500B, upstream-variant-2KB
rs1024496342 -- 149,850,255(+) ATCAA(A/C)TGGGA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BC Gene

Variant ID Type Subtype PubMed ID
esv1007634 OTHER inversion 20482838
nsv46 OTHER inversion 15895083
nsv469694 CNV loss 16826518
nsv499132 OTHER inversion 21111241
nsv7182 OTHER inversion 18451855
nsv831525 CNV gain 17160897
nsv946381 CNV duplication 23825009

Relevant External Links for HIST2H2BC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST2H2BC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H2BC Gene

Disorders for HIST2H2BC Gene

Relevant External Links for HIST2H2BC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST2H2BC

No disorders were found for HIST2H2BC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2BC Gene

Publications for HIST2H2BC Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 3 4 64
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  3. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4 64
  4. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for HIST2H2BC Gene

Sources for HIST2H2BC Gene

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