Aliases for HIST2H2BC Gene
Aliases for HIST2H2BC Gene
External Ids for HIST2H2BC Gene
- HGNC: 20516
- Entrez Gene: 337873
- Ensembl: ENSG00000203819
- UniProtKB: Q6DN03
Previous GeneCards Identifiers for HIST2H2BC Gene
- GC01U900036
- GC01M147038
- GC01M146635
- GC01M148089
- GC01M148090
- GC01M148091
- GC01M149821
- GC01P121197
- GC01M149852
- GC01M149858
- GC01M149862
Summaries for HIST2H2BC Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]
GeneCards Summary for HIST2H2BC Gene
HIST2H2BC (Histone Cluster 2 H2B Family Member C (Pseudogene)) is a Pseudogene.
UniProtKB/Swiss-Prot for HIST2H2BC Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BC Gene
Genomics for HIST2H2BC Gene
Regulatory Elements for HIST2H2BC Gene
Enhancers for HIST2H2BC Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST2H2BC on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST2H2BC Gene
- Chromosome:
- 1
- Start:
- 149,850,192 bp from pter
- End:
- 149,850,773 bp from pter
- Size:
- 582 bases
- Orientation:
- Minus strand
Genomic View for HIST2H2BC Gene
Genes around HIST2H2BC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
HIST2H2BC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST2H2BC Gene
Proteins for HIST2H2BC Gene
-
Protein details for HIST2H2BC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6DN03-H2B2C_HUMAN
- Recommended name:
- Putative histone H2B type 2-C
- Protein Accession:
- Q6DN03
- B7Z677
Protein attributes for HIST2H2BC Gene
- Size:
- 193 amino acids
- Molecular mass:
- 21472 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- Miscellaneous:
-
- The mouse orthologous protein seems not to exist.
Protein Expression for HIST2H2BC Gene
Post-translational modifications for HIST2H2BC Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Antibody Products
- Search GeneTex for Antibodies for HIST2H2BC
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIST2H2BC
- Origene Custom Protein Services for HIST2H2BC
- Search GeneTex for Proteins for HIST2H2BC
Assay Products
No data available for DME Specific Peptides for HIST2H2BC Gene
Domains & Families for HIST2H2BC Gene
Gene Families for HIST2H2BC Gene
- HGNC:
Protein Domains for HIST2H2BC Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST2H2BC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6DN03- Family:
-
- Belongs to the histone H2B family.
Function for HIST2H2BC Gene
Molecular function for HIST2H2BC Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes for HIST2H2BC Gene
- GenomeRNAi human phenotypes for HIST2H2BC:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for HIST2H2BC
CRISPR Products
- Browse CRISPR knockouts for HIST2H2BC
miRNA for HIST2H2BC Gene
- miRTarBase miRNAs that target HIST2H2BC
miRNA Products
- Search ViGene Biosciences for HIST2H2BC
Inhibitory RNA Products
- Search ViGene Biosciences for HIST2H2BC
Cell Line Products
- Search ViGene Biosciences for HIST2H2BC
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2BC Gene
Localization for HIST2H2BC Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BC Gene
- Nucleus. Chromosome.
No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HIST2H2BC Gene
Pathways & Interactions for HIST2H2BC Gene
No data available for Pathways by source and SIGNOR curated interactions for HIST2H2BC Gene
Transcripts for HIST2H2BC Gene
mRNA/cDNA for HIST2H2BC Gene
- (3) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST2H2BC Gene
CRISPR Products
- Browse CRISPR knockouts for HIST2H2BC
miRNA Products
- Search ViGene Biosciences for HIST2H2BC
Inhibitory RNA Products
- Search ViGene Biosciences for HIST2H2BC
Flow Cytometry Products
Expression for HIST2H2BC Gene
mRNA differential expression in normal tissues according to GTEx for HIST2H2BC Gene
This gene is overexpressed in Whole Blood (x5.7).
This gene is overexpressed in Pancreas (31.0), Monocytes (20.3), Blymphocyte (9.3), and Tlymphocyte (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST2H2BC Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST2H2BC Gene:
HIST2H2BCSOURCE GeneReport for Unigene cluster for HIST2H2BC Gene:
Hs.666643Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2BC Gene
Orthologs for HIST2H2BC Gene
No data available for Orthologs for HIST2H2BC Gene
Paralogs for HIST2H2BC Gene
(20) SIMAP similar genes for HIST2H2BC Gene using alignment to 1 proteins:
No data available for Paralogs for HIST2H2BC Gene
Variants for HIST2H2BC Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1009565784 | -- | 149,849,706(+) | GATTT(G/T)AGGGT | downstream-variant-500B, upstream-variant-2KB | |
| rs1013070338 | -- | 149,850,237(+) | AGACG(C/T)GAAGC | nc-transcript-variant, upstream-variant-2KB | |
| rs1013085481 | -- | 149,850,002(+) | ACTTA(C/T)CAAAA | downstream-variant-500B, upstream-variant-2KB | |
| rs1015153667 | -- | 149,849,708(+) | TTTTA(C/G)GGTAT | downstream-variant-500B, upstream-variant-2KB | |
| rs1024496342 | -- | 149,850,255(+) | ATCAA(A/C)TGGGA | nc-transcript-variant, upstream-variant-2KB |
Relevant External Links for HIST2H2BC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST2H2BC
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H2BC Gene
Disorders for HIST2H2BC Gene
Relevant External Links for HIST2H2BC
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST2H2BC
No disorders were found for HIST2H2BC Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2BC Gene
Publications for HIST2H2BC Gene
- Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad C.D. … Stein G.S. (Gene 2004) 2 3 4 64
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4 64
- Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4 64
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
Products for HIST2H2BC Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- GenScript Custom overexpressing Cell Line Services for HIST2H2BC
- Browse GenScript CRISPR for HIST2H2BC
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST2H2BC
- VectorBuilder custom plasmid, inducible vectors for HIST2H2BC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST2H2BC
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST2H2BC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer