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Aliases for HIST2H2BA Gene

Aliases for HIST2H2BA Gene

  • Histone Cluster 2 H2B Family Member A (Pseudogene) 2 3 5
  • Histone Cluster 2, H2ba (Pseudogene) 2
  • Histone Cluster 2, H2ba 2
  • Histone 2, H2ba 2

External Ids for HIST2H2BA Gene

Previous GeneCards Identifiers for HIST2H2BA Gene

  • GC01U900038
  • GC01M147000
  • GC01P120618
  • GC01P120707
  • GC01P120907
  • GC01P120909
  • GC01P120912
  • GC01P120916

Summaries for HIST2H2BA Gene

Entrez Gene Summary for HIST2H2BA Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a histone pseudogene found on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for HIST2H2BA Gene

HIST2H2BA (Histone Cluster 2 H2B Family Member A (Pseudogene)) is a Pseudogene.

Additional gene information for HIST2H2BA Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BA Gene

Genomics for HIST2H2BA Gene

GeneHancer (GH) Regulatory Elements for HIST2H2BA Gene

Promoters and enhancers for HIST2H2BA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I121116 Promoter 0.5 Ensembl 550.8 -0.2 -244 3 ENSG00000234998 HIST2H3DP1 HIST2H2BA ENSG00000227193
GH01I121518 Promoter/Enhancer 1.5 Ensembl ENCODE 22.5 -402.1 -402066 1.9 FOXA2 ZNF493 ZNF133 DMAP1 ZNF2 ZNF48 GLIS2 KLF7 SP3 RXRA ENSG00000272583 GC01M121519 EMBP1 HIST2H2BA ENSG00000227082
GH01I121015 Enhancer 1 Ensembl 11.2 +100.9 100920 1.5 ATF1 ARNT ZNF2 NCOA2 GTF3C2 ZNF213 E2F8 FOS ATF7 KLF13 GC01M121016 HIST2H2BA LOC100996721 LOC101929798
GH01I121366 Enhancer 0.7 dbSUPER 6.8 -251.6 -251614 4.8 BCOR LEF1 TAL1 TCF12 NCOR1 EGR1 CBFA2T2 PRDM10 SMARCA5 GATAD2A PIR52368 HIST2H2BA PIR43395 SRGAP2-AS1 SRGAP2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST2H2BA on UCSC Golden Path with GeneCards custom track

Genomic Locations for HIST2H2BA Gene

Genomic Locations for HIST2H2BA Gene
chr1:121,108,210-121,117,257
(GRCh38/hg38)
Size:
9,048 bases
Orientation:
Minus strand
chr1:120,906,028-120,915,073
(GRCh37/hg19)

Genomic View for HIST2H2BA Gene

Genes around HIST2H2BA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H2BA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H2BA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BA Gene

Proteins for HIST2H2BA Gene

Post-translational modifications for HIST2H2BA Gene

No Post-translational modifications

No data available for DME Specific Peptides for HIST2H2BA Gene

Domains & Families for HIST2H2BA Gene

Gene Families for HIST2H2BA Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HIST2H2BA: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HIST2H2BA Gene

Function for HIST2H2BA Gene

Phenotypes for HIST2H2BA Gene

genes like me logo Genes that share phenotypes with HIST2H2BA: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIST2H2BA Gene

Localization for HIST2H2BA Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HIST2H2BA Gene

Pathways & Interactions for HIST2H2BA Gene

SuperPathways for HIST2H2BA Gene

No Data Available

Interacting Proteins for HIST2H2BA Gene

Gene Ontology (GO) - Biological Process for HIST2H2BA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HIST2H2BA Gene

Drugs & Compounds for HIST2H2BA Gene

No Compound Related Data Available

Transcripts for HIST2H2BA Gene

mRNA/cDNA for HIST2H2BA Gene

(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2BA Gene

Histone cluster 2, H2ba (pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BA Gene

No ASD Table

Relevant External Links for HIST2H2BA Gene

GeneLoc Exon Structure for
HIST2H2BA
ECgene alternative splicing isoforms for
HIST2H2BA

Expression for HIST2H2BA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H2BA Gene

mRNA differential expression in normal tissues according to GTEx for HIST2H2BA Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.2), Brain - Cerebellum (x4.7), and Ovary (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of HIST2H2BA Gene:

HIST2H2BA

SOURCE GeneReport for Unigene cluster for HIST2H2BA Gene:

Hs.742189
genes like me logo Genes that share expression patterns with HIST2H2BA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2BA Gene

Orthologs for HIST2H2BA Gene

Evolution for HIST2H2BA Gene

ENSEMBL:
Gene Tree for HIST2H2BA (if available)
TreeFam:
Gene Tree for HIST2H2BA (if available)

No data available for Orthologs for HIST2H2BA Gene

Paralogs for HIST2H2BA Gene

No data available for Paralogs for HIST2H2BA Gene

Variants for HIST2H2BA Gene

Sequence variations from dbSNP and Humsavar for HIST2H2BA Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs111283173 -- 121,114,540(-) G/T intron_variant
rs111372508 -- 121,108,506(-) G/T non_coding_transcript_variant
rs111450182 -- 121,115,952(-) T/A intron_variant
rs112184898 -- 121,116,494(-) C/A intron_variant
rs112656462 -- 121,111,943(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BA Gene

Variant ID Type Subtype PubMed ID
nsv524681 CNV gain 19592680

Additional Variant Information for HIST2H2BA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST2H2BA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H2BA Gene

Disorders for HIST2H2BA Gene

Additional Disease Information for HIST2H2BA

No disorders were found for HIST2H2BA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2BA Gene

Publications for HIST2H2BA Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 58
  2. Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line. (PMID: 20194426) González-Romero R … Eirín-López JM (Molecular biology and evolution 2010) 3 58
  3. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. (PMID: 16322561) Hublitz P … Schüle R (Genes & development 2005) 3 58
  4. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. (PMID: 14992727) Hughes CM … Meyerson M (Molecular cell 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for HIST2H2BA Gene

Sources for HIST2H2BA Gene

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