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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H2AC Gene

protein-coding   GIFtS: 55
GCID: GC01P149858

histone cluster 2, H2ac

(Previous names: H2A histone family, member Q, histone 2, H2ac )
(Previous symbols: H2A, H2AFQ)
 Explore 8 diseases affiliated with
HIST2H2AC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST2H2AC    

Aliases
for HIST2H2AC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 2, H2ac1 2     Histone H2A-GL1012 3
H2AFQ1 2 3 5     Histone H2A/Q2 3
H2A1 2     H2A-GL1012
H2A/Q1     Histone H2A Type 2-C2
H2A Histone Family, Member Q1 2     Histone IIa2
Histone 2, H2ac1 2     

External Ids:    HGNC: 47381   Entrez Gene: 83382   Ensembl: ENSG000001842607   OMIM: 6027975   UniProtKB: Q167773   

Export aliases for HIST2H2AC gene to outside databases

Previous GC identifers: GC01P145600 GC01P146633 GC01P147075 GC01P146671 GC01P148125 GC01P121239


Summaries
for HIST2H2AC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST2H2AC:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H2A family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2A2C_HUMAN, Q16777
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H2AC


Genomic Views
for HIST2H2AC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H2AC gene promoter:
         TBP   USF1   USF-1   POU3F1   GCNF-1   GCNF   USF-1:USF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST2H2AC promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST2H2AC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H2AC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2AC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2AC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149858:  view genomic region     (about GC identifiers)

Start:
 149,858,525 bp from pter      End:
 149,858,961 bp from pter
Size:
 437 bases      Orientation:
 plus strand

Proteins
for HIST2H2AC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2A2C_HUMAN, Q16777 (See protein sequence)
Recommended Name: Histone H2A type 2-C  
Size: 129 amino acids; 13988 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=13890.8; Method=Electrospray; Range=2-129; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: Q6DRA7 Q8IUE5

Explore the universe of human proteins at neXtProt for HIST2H2AC: NX_Q16777

Post-translational modifications:

  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    • transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by
    RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks
    (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases
    RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and
    Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates
    monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able
    to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked
    ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    • similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16777

    • HIST2H2AC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003508.1  
    ENSEMBL proteins: 
     ENSP00000332194  
    Reactome Protein details: Q16777
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HIST2H2AC
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    Novus Biologicals HIST2H2AC Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST2H2AC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005634nucleus IEA--


    HIST2H2AC for ontologies           About GeneDecksing



    HIST2H2AC Antibody Products: 
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    Uscn Antibodies for HIST2H2AC
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    Uscn ELISAs and CLIAs for HIST2H2AC

    Protein Domains /
    Families
    for HIST2H2AC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST2H2AC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q16777

    ProtoNet protein and cluster: Q16777

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A2C_HUMAN, Q16777
    Similarity: Belongs to the histone H2A family


    Function
    for HIST2H2AC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2A2C_HUMAN, Q16777
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST2H2AC
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST2H2AC:
    hsa-miR-1276
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HIST2H2AC

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST2H2AC

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0046982protein heterodimerization activity IEA--


    HIST2H2AC for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIST2H2AC:
     Decreased TP53 protein express 


    Pathways & Interactions
    for HIST2H2AC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Packaging Of Telomere Ends0.54
    		Telomere clustering at the nuclear membrane0.82
    		Telomere Maintenance0.38
    		Meiosis0.70
    		Meiotic Recombination0.32
    		Chromosome Maintenance0.56
    2RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    3Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    4Disease
    		Disease1.00
    5Cell Cycle
    		Cell Cycle1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST2H2AC
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST2H2AC
        Signal transduction Activin A signaling regulation

    5/14        Reactome Pathways for HIST2H2AC (see all 14)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Deposition of New CENPA-containing Nucleosomes at the Centromere


    1         Kegg Pathway  (Kegg details for HIST2H2AC):
        Systemic lupus erythematosus


    HIST2H2AC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H2AC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for HIST2H2AC (Q167773 ENSP000003321944) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628053, ENSP000003581624I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--


    HIST2H2AC for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST2H2AC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H2AC

    1 HMDB Compound for HIST2H2AC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about HIST2H2AC / H2A2C 

    Transcripts
    for HIST2H2AC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST2H2AC gene: 
    NM_003517.2  

    Unigene Cluster for HIST2H2AC:

    Histone cluster 2, H2ac
    Hs.408067  [show with all ESTs]
    Unigene Representative Sequence: EL734895
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331380(uc001etd.3)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST2H2AC:
    hsa-miR-1276
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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST2H2AC

    Additional cDNA sequence: BC060324.1 

    2 DOTS entries:

    DT.101959106  DT.87015210 

    24/86 AceView cDNA sequences (see all 86):

    CA426321 BU753853 NM_003517 CK902603 AA483644 CA389141 H50355 CF529345 
    BI822618 BC063405 CF529778 AA760787 BX282022 BC060324 CF127829 AA593682 
    AA810028 BM792648 Z40409 BC002771 AI148402 BE384900 BF970430 BU729871 

    GeneLoc Exon Structure


    Expression
    for HIST2H2AC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H2AC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGGCGGTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST2H2AC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST2H2AC Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.408067
        SABiosciences Custom PCR Arrays for HIST2H2AC
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST2H2AC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H2AC gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4278951 histone H2A-IV-like 85.79(n)
    97.67(a)    		   427895  XM_425469.3  XP_425469.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HIST1H2AA6
    --
    (see all 3)    		 --
    		 98(a)
    83(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 GL343252.1(1827542-1827931)
    GL343252.1(1819594-1819782)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1018466
    zgc:1104346
    (see all 31)    		 zgc:110434
    (see all 31)    		 94(a)
    93(a)
    (see all 31)    		 1 ↔ many
    possible ortholog
    (see all 31)    		 10(30724444-30725341)
    25(37347968-37348354)
    fruit fly
    (Drosophila melanogaster)    		 Insecta His2A:CG338566
    His2A:CG338176
    (see all 20)    		 His2A:CG33817
    (see all 20)    		 88(a)
    88(a)
    (see all 20)    		 possible ortholog
    possible ortholog
    (see all 20)    		 2L(21523515-21524083)
    2L(21458012-21458580)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons H2AXA1 putative histone H2AXa 61.75(n)
    71.31(a)    		   837409  NM_100760.4  NP_172363.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g07219001 hypothetical protein 76.61(n)
    79.82(a)    		   4333939  NM_001057641.1  NP_001051106.1 


    ENSEMBL Gene Tree for HIST2H2AC (if available)
    TreeFam Gene Tree for HIST2H2AC (if available) 

    Paralogs
    for HIST2H2AC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H2AC gene
    HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST2H2AA42  HIST1H2AE2  HIST1H2AB2  HIST1H2AK2  HIST1H2AL2  
    H2AFJ2  
    18/26 SIMAP similar genes for HIST2H2AC using alignment to 1 protein entry:     H2A2C_HUMAN(see all similar genes):
    H2AFJ    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG
    HIST1H2AH    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM
    HIST2H2AA3    HIST2H2AA4    HIST2H2AB    HIST3H2A    H2AFX    HIST1H2AA

    HIST2H2AC for paralogs           About GeneDecksing



    Genomic Variants
    for HIST2H2AC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/48 NCBI SNPs in HIST2H2AC are shown (see all 48)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1142307381,2
    		C,F,--149856562(+) AACTGA/CGNNNN 2 -- us2k1 ut311Minor allele frequency- C:0.02NA 120
    rs558854121,2
    		C,--149856720(+) NNNNTC/TTAATG 2 -- us2k1 ut312Minor allele frequency- T:0.13NA 122
    rs1162765521,2
    		C,F,--149856813(+) CAATAC/TGTAGT 2 -- us2k1 ut311Minor allele frequency- T:0.03WA 118
    rs1921102941,2
    		--149856816(+) TACGTA/GGTATT 2 -- us2k1 ut310--------
    rs1425036321,2
    		--149856908(+) ACAAGA/CAAACA 2 -- ut31 us2k10--------
    rs1840086061,2
    		--149857144(+) GTCTCA/GAAGTG 2 -- ut31 us2k10--------
    rs1451621741,2
    		C,--149857553(+) AGCAG-/CACAATG 2 -- ut31 us2k10--------
    rs1877086441,2
    		--149857606(+) CACTGA/GGGACC 2 -- ut31 us2k10--------
    rs1505391221,2
    		--149857639(+) GCTACA/GTATGC 2 -- us2k1 ut310--------
    rs1129106631,2
    		C,--149858202(+) ACACAG/ATACAA 2 -- us2k1 ut511Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for HIST2H2AC (149858525 - 149858961 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HIST2H2AC
         3 CNVs: 3313 2326 8329
         1 Inversion: 37081

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    Disorders / Diseases
    for HIST2H2AC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST2H2AC for disorders           About GeneDecksing

    OMIM gene information: 602797    OMIM disorders: --

    8 diseases for HIST2H2AC:    About MalaCards
    xeroderma pigmentosum    connective tissue disease    x inactivation    riddle syndrome
    systemic lupus erythematosus    lupus erythematosus    cockayne syndrome    immunodeficiency

    3 diseases from the University of Copenhagen DISEASES database for HIST2H2AC:
    Lupus erythematosus     Connective tissue disease     Cleft palate

    Export disorders for HIST2H2AC gene to outside databases

    Publications
    for HIST2H2AC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H2AC gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with HIST2H2AC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PubMed id 1469070)1, 2, 3 Collart D.... Stein G.S. (1992)
    3. The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. (PubMed id 19203578)1, 2 Stewart G.S....Durocher D. (2009)
    4. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (2006)
    5. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2 Bonenfant D.... van Oostrum J. (2006)
    6. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    9. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (2005)
    10. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (2004)

    External Searches for HIST2H2AC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST2H2AC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8338 HGNC: 4738 AceView: HIST2H2ACandCGI-143 Ensembl:ENSG00000184260 euGenes: HUgn8338
    ECgene: HIST2H2AC Kegg: 8338 H-InvDB: HIST2H2AC

    Other Databases showing HIST2H2AC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST2H2AC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H2AC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST2H2AC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST2H2AC gene:
    Search GeneIP for patents involving HIST2H2AC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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