Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST2H2AB Gene

Aliases for HIST2H2AB Gene

  • Histone Cluster 2, H2ab 2 3
  • Histone 2, H2ab 2 3
  • H2AB 3 6
  • Histone H2A Type 2-B 3

External Ids for HIST2H2AB Gene

Previous GeneCards Identifiers for HIST2H2AB Gene

  • GC01M145601
  • GC01M146634
  • GC01M147075
  • GC01M146672
  • GC01M148125
  • GC01M149861
  • GC01M121239

Summaries for HIST2H2AB Gene

Entrez Gene Summary for HIST2H2AB Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST2H2AB Gene

HIST2H2AB (Histone Cluster 2, H2ab) is a Protein Coding gene. Diseases associated with HIST2H2AB include hiv-1 and colorectal cancer. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2AM.

UniProtKB/Swiss-Prot for HIST2H2AB Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H2AB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2AB Gene

Genomics for HIST2H2AB Gene

Regulatory Elements for HIST2H2AB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST2H2AB Gene

Start:
149,887,469 bp from pter
End:
149,887,916 bp from pter
Size:
448 bases
Orientation:
Minus strand

Genomic View for HIST2H2AB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST2H2AB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2AB Gene

Proteins for HIST2H2AB Gene

  • Protein details for HIST2H2AB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUE6-H2A2B_HUMAN
    Recommended name:
    Histone H2A type 2-B
    Protein Accession:
    Q8IUE6
    Secondary Accessions:

    Protein attributes for HIST2H2AB Gene

    Size:
    130 amino acids
    Molecular mass:
    13995 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for HIST2H2AB Gene

Proteomics data for HIST2H2AB Gene at MOPED

Post-translational modifications for HIST2H2AB Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys14, Lys16, Lys96, Lys119, and Lys120
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H2AB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST2H2AB Gene

Domains for HIST2H2AB Gene

Gene Families for HIST2H2AB Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST2H2AB Gene

Suggested Antigen Peptide Sequences for HIST2H2AB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUE6

UniProtKB/Swiss-Prot:

H2A2B_HUMAN :
  • Q8IUE6
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST2H2AB: view

Function for HIST2H2AB Gene

Molecular function for HIST2H2AB Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST2H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H2AB: view

miRNA for HIST2H2AB Gene

miRTarBase miRNAs that target HIST2H2AB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H2AB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST2H2AB Gene

Localization for HIST2H2AB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2AB Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST2H2AB Gene COMPARTMENTS Subcellular localization image for HIST2H2AB gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST2H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HIST2H2AB: view

Pathways for HIST2H2AB Gene

genes like me logo Genes that share pathways with HIST2H2AB: view

Pathways by source for HIST2H2AB Gene

2 KEGG pathways for HIST2H2AB Gene

Gene Ontology (GO) - Biological Process for HIST2H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HIST2H2AB: view

Compounds for HIST2H2AB Gene

(1) HMDB Compounds for HIST2H2AB Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HIST2H2AB: view

Transcripts for HIST2H2AB Gene

mRNA/cDNA for HIST2H2AB Gene

(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2AB Gene

Histone cluster 2, H2ab:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H2AB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST2H2AB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2AB Gene

No ASD Table

Relevant External Links for HIST2H2AB Gene

GeneLoc Exon Structure for
HIST2H2AB
ECgene alternative splicing isoforms for
HIST2H2AB

Expression for HIST2H2AB Gene

mRNA expression in normal human tissues for HIST2H2AB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST2H2AB Gene

SOURCE GeneReport for Unigene cluster for HIST2H2AB Gene Hs.664173

genes like me logo Genes that share expressions with HIST2H2AB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST2H2AB Gene

Orthologs for HIST2H2AB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST2H2AB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST2H2AB 36
  • 100 (a)
OneToOne
LOC746557 35
  • 98.97 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HIST2H2AB 35
  • 90 (n)
  • 100 (a)
HIST2H2AB 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
ManyToMany
LOC100855609 35
  • 91.28 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist2h2ab 35
  • 86.67 (n)
  • 99.23 (a)
Hist2h2ab 16
Hist2h2ab 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HIST2H2AB 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hist2h2ab 35
  • 86.41 (n)
  • 98.46 (a)
lizard
(Anolis carolinensis)
Reptilia HIST2H2AB 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492813 35
  • 78.21 (n)
  • 94.62 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100001004 35
  • 77.87 (n)
  • 98.36 (a)
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
zgc:101846 36
  • 95 (a)
ManyToMany
zgc:154164 36
  • 85 (a)
ManyToMany
zgc:154164 36
  • 90 (a)
ManyToMany
zgc:163047 36
  • 94 (a)
ManyToMany
zgc:195633 36
  • 95 (a)
ManyToMany
zgc:195633 36
  • 95 (a)
ManyToMany
zgc:195633 36
  • 88 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012895 35
  • 80.99 (n)
  • 91.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta His2A:CG33859 35
  • 75.76 (n)
  • 91.74 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7584 35
thale cress
(Arabidopsis thaliana)
eudicotyledons HTA2 35
  • 64.29 (n)
  • 77.78 (a)
rice
(Oryza sativa)
Liliopsida Os07g0545400 35
  • 68.6 (n)
  • 77.69 (a)
Species with no ortholog for HIST2H2AB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST2H2AB Gene

ENSEMBL:
Gene Tree for HIST2H2AB (if available)
TreeFam:
Gene Tree for HIST2H2AB (if available)

Paralogs for HIST2H2AB Gene

genes like me logo Genes that share paralogs with HIST2H2AB: view

Variants for HIST2H2AB Gene

Sequence variations from dbSNP and Humsavar for HIST2H2AB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs17581597 -- 149,888,822(+) AGACC(C/T)TTATG upstream-variant-2KB
rs72708151 -- 149,889,648(+) TCGAA(C/T)TCCTG upstream-variant-2KB
rs74124042 -- 149,888,915(+) GAACT(C/G)ATACA upstream-variant-2KB
rs75061824 -- 149,889,399(+) CACCC(A/G)GGCTG upstream-variant-2KB
rs77132702 -- 149,889,358(+) GTGGG(C/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2AB Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
nsv7182 OTHER Inversion 18451855
nsv831537 CNV Loss 17160897

Relevant External Links for HIST2H2AB Gene

HapMap Linkage Disequilibrium report
HIST2H2AB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H2AB Gene

Disorders for HIST2H2AB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HIST2H2AB Gene including...

Search for HIST2H2AB Gene in MalaCards »
genes like me logo Genes that share disorders with HIST2H2AB: view

No data available for UniProtKB/Swiss-Prot for HIST2H2AB Gene

Publications for HIST2H2AB Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  2. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PMID: 15010469) Zhang Y. … Parvin J.D. (J. Biol. Chem. 2004) 3 4
  3. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PMID: 15078818) Aihara H. … Ito T. (Genes Dev. 2004) 3 4
  4. Role of histone H2A ubiquitination in Polycomb silencing. (PMID: 15386022) Wang H. … Zhang Y. (Nature 2004) 3 4
  5. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PMID: 15823041) Hagiwara T. … Yamada M. (Biochemistry 2005) 3 4

Products for HIST2H2AB Gene

Sources for HIST2H2AB Gene

Back to Top

Content