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Aliases for HIST2H2AB Gene

Aliases for HIST2H2AB Gene

  • Histone Cluster 2, H2ab 2 3 5
  • Histone 2, H2ab 2 3
  • H2AB 3

External Ids for HIST2H2AB Gene

Previous GeneCards Identifiers for HIST2H2AB Gene

  • GC01M145601
  • GC01M146634
  • GC01M147075
  • GC01M146672
  • GC01M148125
  • GC01M149861
  • GC01M121239
  • GC01M149888
  • GC01M149890

Summaries for HIST2H2AB Gene

Entrez Gene Summary for HIST2H2AB Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST2H2AB Gene

HIST2H2AB (Histone Cluster 2, H2ab) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AM.

UniProtKB/Swiss-Prot for HIST2H2AB Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST2H2AB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2AB Gene

Genomics for HIST2H2AB Gene

Regulatory Elements for HIST2H2AB Gene

Enhancers for HIST2H2AB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIST2H2AB on UCSC Golden Path with GeneCards custom track

Promoters for HIST2H2AB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST2H2AB on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST2H2AB Gene

Chromosome:
1
Start:
149,887,469 bp from pter
End:
149,887,916 bp from pter
Size:
448 bases
Orientation:
Minus strand

Genomic View for HIST2H2AB Gene

Genes around HIST2H2AB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H2AB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H2AB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2AB Gene

Proteins for HIST2H2AB Gene

  • Protein details for HIST2H2AB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUE6-H2A2B_HUMAN
    Recommended name:
    Histone H2A type 2-B
    Protein Accession:
    Q8IUE6

    Protein attributes for HIST2H2AB Gene

    Size:
    130 amino acids
    Molecular mass:
    13995 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for HIST2H2AB Gene

Proteomics data for HIST2H2AB Gene at MOPED

Post-translational modifications for HIST2H2AB Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys 14 and Lys 16
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H2AB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST2H2AB Gene

Domains & Families for HIST2H2AB Gene

Gene Families for HIST2H2AB Gene

Protein Domains for HIST2H2AB Gene

Suggested Antigen Peptide Sequences for HIST2H2AB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUE6

UniProtKB/Swiss-Prot:

H2A2B_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST2H2AB: view

Function for HIST2H2AB Gene

Molecular function for HIST2H2AB Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST2H2AB: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2AB Gene

Localization for HIST2H2AB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2AB Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST2H2AB Gene COMPARTMENTS Subcellular localization image for HIST2H2AB gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for HIST2H2AB Gene

Pathways & Interactions for HIST2H2AB Gene

genes like me logo Genes that share pathways with HIST2H2AB: view

Pathways by source for HIST2H2AB Gene

Gene Ontology (GO) - Biological Process for HIST2H2AB Gene

None

No data available for SIGNOR curated interactions for HIST2H2AB Gene

Drugs & Compounds for HIST2H2AB Gene

(1) Drugs for HIST2H2AB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with HIST2H2AB: view

Transcripts for HIST2H2AB Gene

mRNA/cDNA for HIST2H2AB Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2AB Gene

Histone cluster 2, H2ab:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2AB Gene

No ASD Table

Relevant External Links for HIST2H2AB Gene

GeneLoc Exon Structure for
HIST2H2AB
ECgene alternative splicing isoforms for
HIST2H2AB

Expression for HIST2H2AB Gene

mRNA expression in normal human tissues for HIST2H2AB Gene

Protein differential expression in normal tissues from HIPED for HIST2H2AB Gene

This gene is overexpressed in Blymphocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST2H2AB Gene



SOURCE GeneReport for Unigene cluster for HIST2H2AB Gene Hs.664173

genes like me logo Genes that share expression patterns with HIST2H2AB: view

Protein tissue co-expression partners for HIST2H2AB Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST2H2AB Gene

Orthologs for HIST2H2AB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST2H2AB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIST2H2AB 35
  • 90 (n)
  • 100 (a)
HIST2H2AB 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855609 35
  • 91.28 (n)
  • 100 (a)
-- 36
  • 89 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hist2h2ab 35
  • 86.67 (n)
  • 99.23 (a)
Hist2h2ab 16
Hist2h2ab 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC746557 35
  • 98.97 (n)
  • 100 (a)
HIST2H2AB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hist2h2ab 35
  • 86.41 (n)
  • 98.46 (a)
oppossum
(Monodelphis domestica)
Mammalia HIST2H2AB 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIST2H2AB 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492813 35
  • 78.21 (n)
  • 94.62 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100001004 35
  • 77.87 (n)
  • 98.36 (a)
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
si:ch211-113a14.19 36
  • 95 (a)
ManyToMany
zgc:101846 36
  • 95 (a)
ManyToMany
zgc:154164 36
  • 85 (a)
ManyToMany
zgc:154164 36
  • 90 (a)
ManyToMany
zgc:163047 36
  • 94 (a)
ManyToMany
zgc:195633 36
  • 95 (a)
ManyToMany
zgc:195633 36
  • 95 (a)
ManyToMany
zgc:195633 36
  • 88 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012895 35
  • 80.99 (n)
  • 91.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta His2A:CG33859 35
  • 75.76 (n)
  • 91.74 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HTA2 35
  • 64.29 (n)
  • 77.78 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7584 35
rice
(Oryza sativa)
Liliopsida Os07g0545400 35
  • 68.6 (n)
  • 77.69 (a)
Species with no ortholog for HIST2H2AB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST2H2AB Gene

ENSEMBL:
Gene Tree for HIST2H2AB (if available)
TreeFam:
Gene Tree for HIST2H2AB (if available)

Paralogs for HIST2H2AB Gene

genes like me logo Genes that share paralogs with HIST2H2AB: view

Variants for HIST2H2AB Gene

Sequence variations from dbSNP and Humsavar for HIST2H2AB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035802 A breast cancer sample
rs17581597 -- 149,888,822(+) AGACC(C/T)TTATG upstream-variant-2KB
rs74124042 -- 149,888,915(+) GAACT(C/G)ATACA upstream-variant-2KB
rs72708151 -- 149,889,648(+) TCGAA(C/T)TCCTG upstream-variant-2KB
rs75061824 -- 149,889,399(+) CACCC(A/G)GGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2AB Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
nsv7182 OTHER Inversion 18451855
nsv831537 CNV Loss 17160897

Variation tolerance for HIST2H2AB Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HIST2H2AB Gene

Disorders for HIST2H2AB Gene

Relevant External Links for HIST2H2AB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST2H2AB

No disorders were found for HIST2H2AB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2AB Gene

Publications for HIST2H2AB Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants. (PMID: 25362550) Sadakierska-Chudy A. … Filip M. (Neurotox Res 2015) 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for HIST2H2AB Gene

Sources for HIST2H2AB Gene

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