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Aliases for HIST2H2AB Gene

Aliases for HIST2H2AB Gene

  • Histone Cluster 2 H2A Family Member B 2 3 5
  • Histone Cluster 2, H2ab 2 3
  • Histone 2, H2ab 2 3
  • Histone H2A Type 2-B 3
  • H2AB 3

External Ids for HIST2H2AB Gene

Previous GeneCards Identifiers for HIST2H2AB Gene

  • GC01M145601
  • GC01M146634
  • GC01M147075
  • GC01M146672
  • GC01M148125
  • GC01M149861
  • GC01M121239
  • GC01M149888
  • GC01M149890

Summaries for HIST2H2AB Gene

Entrez Gene Summary for HIST2H2AB Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST2H2AB Gene

HIST2H2AB (Histone Cluster 2 H2A Family Member B) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AC.

UniProtKB/Swiss-Prot for HIST2H2AB Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST2H2AB Gene

Additional gene information for HIST2H2AB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2AB Gene

Genomics for HIST2H2AB Gene

GeneHancer (GH) Regulatory Elements for HIST2H2AB Gene

Promoters and enhancers for HIST2H2AB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I149883 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 593.9 +1.2 1213 5.9 CLOCK MLX ZFP64 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 HIST2H2AB HIST2H2AC HIST2H2BE GC01M149896 BOLA1 PRPF3 SF3B4 UBE2D3P3 ARNT GOLPH3L
GH01I150232 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30 -347.2 -347220 4.8 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ANP32E GC01P150237 RNU2-17P SETDB1 PRPF3 PIP5K1A GABPB2 SF3B4 ARNT UBE2D3P3
GH01I148950 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22 +931.0 931016 13.5 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZC3H11A PDE4DIP LOC647481 SF3B4 LOC101927468 HIST2H2AB ENSG00000227700 HIST2H2BC SV2A PIR31643 PIR33316
GH01I149156 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 24 +727.6 727580 7.8 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 LOC647481 SF3B4 HIST2H2BD VPS45 LOC101927468 HIST2H2AB HIST2H2BC ENSG00000227700 ENSG00000261716 PDE4DIP
GH01I150362 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22 -476.9 -476891 5.2 CLOCK FEZF1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ZC3H11A RPRD2 PRPF3 SETDB1 SF3B4 PI4KB ZNF687 UBE2D3P3 PIP5K1A ARNT HIST2H2AB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST2H2AB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST2H2AB gene promoter:

Genomic Locations for HIST2H2AB Gene

Genomic Locations for HIST2H2AB Gene
chr1:149,887,469-149,887,916
(GRCh38/hg38)
Size:
448 bases
Orientation:
Minus strand
chr1:149,859,019-149,859,466
(GRCh37/hg19)

Genomic View for HIST2H2AB Gene

Genes around HIST2H2AB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H2AB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H2AB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2AB Gene

Proteins for HIST2H2AB Gene

  • Protein details for HIST2H2AB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUE6-H2A2B_HUMAN
    Recommended name:
    Histone H2A type 2-B
    Protein Accession:
    Q8IUE6

    Protein attributes for HIST2H2AB Gene

    Size:
    130 amino acids
    Molecular mass:
    13995 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for HIST2H2AB Gene

Post-translational modifications for HIST2H2AB Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at posLast=1414 and isoforms=16

Other Protein References for HIST2H2AB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST2H2AB Gene

Domains & Families for HIST2H2AB Gene

Gene Families for HIST2H2AB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HIST2H2AB Gene

Suggested Antigen Peptide Sequences for HIST2H2AB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUE6

UniProtKB/Swiss-Prot:

H2A2B_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST2H2AB: view

Function for HIST2H2AB Gene

Molecular function for HIST2H2AB Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST2H2AB Gene

Gene Ontology (GO) - Molecular Function for HIST2H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H2AB: view
genes like me logo Genes that share phenotypes with HIST2H2AB: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2AB Gene

Localization for HIST2H2AB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2AB Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST2H2AB gene
Compartment Confidence
extracellular 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HIST2H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IDA,HDA 21630459
GO:0005694 chromosome IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with HIST2H2AB: view

Pathways & Interactions for HIST2H2AB Gene

genes like me logo Genes that share pathways with HIST2H2AB: view

Pathways by source for HIST2H2AB Gene

Gene Ontology (GO) - Biological Process for HIST2H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HIST2H2AB: view

No data available for SIGNOR curated interactions for HIST2H2AB Gene

Drugs & Compounds for HIST2H2AB Gene

(1) Drugs for HIST2H2AB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with HIST2H2AB: view

Transcripts for HIST2H2AB Gene

mRNA/cDNA for HIST2H2AB Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2AB Gene

Histone cluster 2, H2ab:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2AB Gene

No ASD Table

Relevant External Links for HIST2H2AB Gene

GeneLoc Exon Structure for
HIST2H2AB
ECgene alternative splicing isoforms for
HIST2H2AB

Expression for HIST2H2AB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H2AB Gene

Protein differential expression in normal tissues from HIPED for HIST2H2AB Gene

This gene is overexpressed in Blymphocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST2H2AB Gene



Protein tissue co-expression partners for HIST2H2AB Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST2H2AB Gene:

HIST2H2AB

SOURCE GeneReport for Unigene cluster for HIST2H2AB Gene:

Hs.664173

Evidence on tissue expression from TISSUES for HIST2H2AB Gene

  • Stomach(2.7)
  • Intestine(2.6)
  • Nervous system(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with HIST2H2AB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2AB Gene

Orthologs for HIST2H2AB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST2H2AB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST2H2AB 34
  • 100 (a)
OneToOne
LOC746557 33
  • 98.97 (n)
oppossum
(Monodelphis domestica)
Mammalia HIST2H2AB 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855609 33
  • 91.28 (n)
-- 34
  • 89 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia HIST2H2AB 33 34
  • 90 (n)
mouse
(Mus musculus)
Mammalia Hist2h2ab 33 16 34
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Hist2h2ab 33
  • 86.41 (n)
lizard
(Anolis carolinensis)
Reptilia HIST2H2AB 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734900 33
  • 78.21 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.19 34 34 34 34 34 34
  • 95 (a)
ManyToMany
zgc:195633 34 34 34
  • 95 (a)
ManyToMany
zgc:101846 34
  • 95 (a)
ManyToMany
zgc:163047 34
  • 94 (a)
ManyToMany
zgc:154164 34 34
  • 85 (a)
ManyToMany
LOC100001004 33
  • 77.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012895 33
  • 80.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta His2A:CG33856 33
  • 75.76 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HTA2 33
  • 64.29 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7584 33
rice
(Oryza sativa)
Liliopsida Os07g0545400 33
  • 68.6 (n)
Species where no ortholog for HIST2H2AB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST2H2AB Gene

ENSEMBL:
Gene Tree for HIST2H2AB (if available)
TreeFam:
Gene Tree for HIST2H2AB (if available)

Paralogs for HIST2H2AB Gene

Variants for HIST2H2AB Gene

Sequence variations from dbSNP and Humsavar for HIST2H2AB Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035802 A breast cancer sample p.Ala53Thr
rs1002658115 -- 149,889,842(-) T/C upstream_transcript_variant
rs1003013948 -- 149,889,510(-) G/A upstream_transcript_variant
rs1006397744 -- 149,889,439(-) C/T upstream_transcript_variant
rs1006450550 -- 149,889,717(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2AB Gene

Variant ID Type Subtype PubMed ID
nsv7182 OTHER inversion 18451855
nsv831525 CNV gain 17160897
nsv831537 CNV loss 17160897
nsv946382 CNV duplication 23825009

Variation tolerance for HIST2H2AB Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST2H2AB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST2H2AB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H2AB Gene

Disorders for HIST2H2AB Gene

Additional Disease Information for HIST2H2AB

No disorders were found for HIST2H2AB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2AB Gene

Publications for HIST2H2AB Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  2. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PMID: 16702407) Bergink S … Dantuma NP (Genes & development 2006) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PMID: 15823041) Hagiwara T … Yamada M (Biochemistry 2005) 3 4 58
  5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PMID: 16359901) Cao R … Zhang Y (Molecular cell 2005) 3 4 58

Products for HIST2H2AB Gene

Sources for HIST2H2AB Gene

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