Aliases for HIST2H2AB Gene
Aliases for HIST2H2AB Gene
External Ids for HIST2H2AB Gene
- HGNC: 20508
- Entrez Gene: 317772
- Ensembl: ENSG00000184270
- OMIM: 615014
- UniProtKB: Q8IUE6
Previous GeneCards Identifiers for HIST2H2AB Gene
- GC01M145601
- GC01M146634
- GC01M147075
- GC01M146672
- GC01M148125
- GC01M149861
- GC01M121239
- GC01M149888
- GC01M149890
Summaries for HIST2H2AB Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST2H2AB Gene
HIST2H2AB (Histone Cluster 2 H2A Family Member B) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Deubiquitination. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AC.
UniProtKB/Swiss-Prot for HIST2H2AB Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2AB Gene
Genomics for HIST2H2AB Gene
Regulatory Elements for HIST2H2AB Gene
Enhancers for HIST2H2AB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST2H2AB on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST2H2AB gene promoter:
Regulatory Element Products
Genomic Location for HIST2H2AB Gene
- Chromosome:
- 1
- Start:
- 149,887,469 bp from pter
- End:
- 149,887,916 bp from pter
- Size:
- 448 bases
- Orientation:
- Minus strand
Genomic View for HIST2H2AB Gene
Genes around HIST2H2AB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
HIST2H2AB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST2H2AB Gene
Proteins for HIST2H2AB Gene
-
Protein details for HIST2H2AB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IUE6-H2A2B_HUMAN
- Recommended name:
- Histone H2A type 2-B
- Protein Accession:
- Q8IUE6
Protein attributes for HIST2H2AB Gene
- Size:
- 130 amino acids
- Molecular mass:
- 13995 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST2H2AB Gene
Post-translational modifications for HIST2H2AB Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Ubiquitination at isoforms=14 and isoforms=16
- Modification sites at PhosphoSitePlus
Other Protein References for HIST2H2AB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HIST2H2AB
- Invitrogen Antibodies for HIST2H2AB
- Search GeneTex for Antibodies for HIST2H2AB
Protein Products
-
OriGene Purified Proteins for HIST2H2AB
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST2H2AB
- Origene Custom Protein Services for HIST2H2AB
- Search GeneTex for Proteins for HIST2H2AB
Assay Products
No data available for DME Specific Peptides for HIST2H2AB Gene
Domains & Families for HIST2H2AB Gene
Gene Families for HIST2H2AB Gene
- HGNC:
Protein Domains for HIST2H2AB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST2H2AB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IUE6- Family:
-
- Belongs to the histone H2A family.
Function for HIST2H2AB Gene
Molecular function for HIST2H2AB Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IBA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST2H2AB Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H2AB gene
- Search ViGene Biosciences for HIST2H2AB
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H2AB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H2AB
- GenScript: Design CRISPR guide RNA sequences for HIST2H2AB
miRNA for HIST2H2AB Gene
- miRTarBase miRNAs that target HIST2H2AB
-
- hsa-mir-34a-5p (MIRT025239)
- hsa-mir-615-3p (MIRT040240)
- hsa-mir-760 (MIRT266342)
- hsa-mir-6822-3p (MIRT266348)
- hsa-mir-5572 (MIRT509567)
- hsa-mir-4260 (MIRT509568)
- hsa-mir-450a-2-3p (MIRT509569)
- hsa-mir-6855-5p (MIRT509570)
- hsa-mir-3170 (MIRT509571)
- hsa-mir-6819-5p (MIRT509572)
- hsa-mir-6812-5p (MIRT509573)
- hsa-mir-6737-5p (MIRT509574)
- hsa-mir-8057 (MIRT509575)
- hsa-mir-1257 (MIRT509576)
- hsa-mir-6747-5p (MIRT509577)
- hsa-mir-608 (MIRT509578)
- hsa-mir-4651 (MIRT509579)
- hsa-mir-4664-5p (MIRT509580)
- hsa-mir-342-5p (MIRT509581)
- hsa-mir-496 (MIRT509582)
- hsa-mir-302a-5p (MIRT509583)
- hsa-mir-1276 (MIRT509584)
miRNA Products
- Search ViGene Biosciences for HIST2H2AB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H2AB
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Clone Products
-
OriGene ORF clones in human for HIST2H2AB
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Cell Line Products
-
Horizon Cell Lines for HIST2H2AB
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST2H2AB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST2H2AB gene
- Search ViGene Biosciences for HIST2H2AB
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2AB Gene
Localization for HIST2H2AB Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2AB Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IBA | -- |
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for HIST2H2AB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
| 2 | Chromatin organization | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Metalloprotease DUBs | ||
Pathways by source for HIST2H2AB Gene
11 Reactome pathways for HIST2H2AB Gene
2 KEGG pathways for HIST2H2AB Gene
Interacting Proteins for HIST2H2AB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006342 | chromatin silencing | IBA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for HIST2H2AB Gene
Drugs & Compounds for HIST2H2AB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for HIST2H2AB Gene
mRNA/cDNA for HIST2H2AB Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST2H2AB Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST2H2AB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST2H2AB
- GenScript: Design CRISPR guide RNA sequences for HIST2H2AB
miRNA Products
- Search ViGene Biosciences for HIST2H2AB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST2H2AB
- Browse OriGene Inhibitory RNA Products For HIST2H2AB
- Search ViGene Biosciences for HIST2H2AB
Clone Products
-
OriGene ORF clones in human for HIST2H2AB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST2H2AB Gene
This gene is overexpressed in Blymphocyte (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST2H2AB Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST2H2AB Gene:
HIST2H2ABSOURCE GeneReport for Unigene cluster for HIST2H2AB Gene:
Hs.664173Evidence on tissue expression from TISSUES for HIST2H2AB Gene
- Stomach(2.7)
- Intestine(2.6)
- Nervous system(2.3)
- Bone marrow(2.2)
Primer Products
-
OriGene qPCR primer pairs for HIST2H2AB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2AB Gene
Orthologs for HIST2H2AB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIST2H2AB 35 |
|
OneToOne | |
| LOC746557 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | HIST2H2AB 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC100855609 34 |
|
||
| -- 35 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | HIST2H2AB 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist2h2ab 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hist2h2ab 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HIST2H2AB 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101734900 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-113a14.19 35 35 35 35 35 35 |
|
ManyToMany | |
| zgc:101846 35 |
|
ManyToMany | |||
| zgc:195633 35 35 35 |
|
ManyToMany | |||
| zgc:163047 35 |
|
ManyToMany | |||
| zgc:154164 35 35 |
|
ManyToMany | |||
| LOC100001004 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012895 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His2A:CG33853 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | HTA2 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7584 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0545400 34 |
|
- Species where no ortholog for HIST2H2AB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST2H2AB Gene
Paralogs for HIST2H2AB Gene
(26) SIMAP similar genes for HIST2H2AB Gene using alignment to 1 proteins:
Variants for HIST2H2AB Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035802 | A breast cancer sample | ||||
| rs1002658115 | -- | 149,889,842(+) | GATAA(C/T)TGAAA | upstream-variant-2KB | |
| rs1003013948 | -- | 149,889,510(+) | GCTGG(A/G)ATGAC | upstream-variant-2KB | |
| rs1006397744 | -- | 149,889,439(+) | ACCAC(C/T)GCCTC | upstream-variant-2KB | |
| rs1006450550 | -- | 149,889,717(+) | ACTGC(A/G)CCCGG | upstream-variant-2KB |
Residual Variation Intolerance Score:
42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.01% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST2H2AB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST2H2AB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H2AB Gene
Disorders for HIST2H2AB Gene
Relevant External Links for HIST2H2AB
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST2H2AB
No disorders were found for HIST2H2AB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2AB Gene
Publications for HIST2H2AB Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PMID: 16702407) Bergink S. … Dantuma N.P. (Genes Dev. 2006) 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PMID: 15823041) Hagiwara T. … Yamada M. (Biochemistry 2005) 3 4 64
- Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PMID: 16359901) Cao R. … Zhang Y. (Mol. Cell 2005) 3 4 64
Products for HIST2H2AB Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST2H2AB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
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