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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H2AB Gene

protein-coding   GIFtS: 46
GCID: GC01M149861

histone cluster 2, H2ab

(Previous names: histone 2, H2ab )
 Explore 5 diseases affiliated with
HIST2H2AB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST2H2AB    

Aliases
for HIST2H2AB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 2, H2ab1 2
Histone 2, H2ab1 2
H2AB2
Histone H2A Type 2-B2

External Ids:    HGNC: 205081   Entrez Gene: 3177722   Ensembl: ENSG000001842707   OMIM: 6150145   UniProtKB: Q8IUE63   

Export aliases for HIST2H2AB gene to outside databases

Previous GC identifers: GC01M145601 GC01M146634 GC01M147075 GC01M146672 GC01M148125 GC01M121239


Summaries
for HIST2H2AB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST2H2AB:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of
each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a
palindromic termination element. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2A2B_HUMAN, Q8IUE6
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H2AB


Genomic Views
for HIST2H2AB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H2AB gene promoter:
         TBP   POU3F1   GCNF-1   GCNF   ARP-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST2H2AB promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST2H2AB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H2AB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2AB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2AB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149861:  view genomic region     (about GC identifiers)

Start:
 149,859,019 bp from pter      End:
 149,859,466 bp from pter
Size:
 448 bases      Orientation:
 minus strand

Proteins
for HIST2H2AB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2A2B_HUMAN, Q8IUE6 (See protein sequence)
Recommended Name: Histone H2A type 2-B  
Size: 130 amino acids; 13995 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome

Explore the universe of human proteins at neXtProt for HIST2H2AB: NX_Q8IUE6

Post-translational modifications:

  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    • transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by
    RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks
    (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases
    RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and
    Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates
    monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able
    to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked
    ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    • similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IUE6

    • HIST2H2AB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_778235.1  
    ENSEMBL proteins: 
     ENSP00000332790  

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    Uscn Proteins for HIST2H2AB

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--


    HIST2H2AB for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HIST2H2AB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST2H2AB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q8IUE6

    ProtoNet protein and cluster: Q8IUE6

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A2B_HUMAN, Q8IUE6
    Similarity: Belongs to the histone H2A family


    Function
    for HIST2H2AB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2A2B_HUMAN, Q8IUE6
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
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    hsa-miR-1276
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    HIST2H2AB for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST2H2AB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Systemic lupus erythematosus
    		Systemic lupus erythematosus1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for HIST2H2AB):
        Systemic lupus erythematosus


    HIST2H2AB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST2H2AB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/10 Interacting proteins for HIST2H2AB (Q8IUE63 ENSP000003327904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT1Q96EB63, ENSP000002120154I2D: score=2 STRING: ENSP00000212015
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    SMARCA5O602643, ENSP000002831314I2D: score=1 STRING: ENSP00000283131
    WDR77Q9BQA13, ENSP000002350904I2D: score=1 STRING: ENSP00000235090
    BARD1Q997283, ENSP000002609474I2D: score=1 STRING: ENSP00000260947
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--


    HIST2H2AB for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST2H2AB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HIST2H2AB

    1 HMDB Compound for HIST2H2AB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about HIST2H2AB / H2A2B 

    Transcripts
    for HIST2H2AB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST2H2AB gene: 
    NM_175065.2  

    Unigene Cluster for HIST2H2AB:

    Histone cluster 2, H2ab
    Hs.664173
    Unigene Representative Sequence: BC132811
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331128(uc001ete.3)

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    hsa-miR-1276
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: BC132811.1 

    1 DOTS entry:

    DT.99947181 

    1 AceView cDNA sequence:

    NM_175065 

    GeneLoc Exon Structure


    Expression
    for HIST2H2AB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H2AB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST2H2AB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST2H2AB Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.664173
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST2H2AB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H2AB gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    HIST1H2AA6
    		 --
    		 84(a)
    60(a)
    		 possible ortholog
    possible ortholog
    		 GL343252.1(1819594-1819782)
    GL344481.1(11179-11601)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000010041 histone H2A-like 77.87(n)
    98.36(a)    		   100001004  XM_001335354.1  XP_001335390.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta His2A:CG338441 CG33844-PA 75.76(n)
    91.74(a)    		   3772565  NM_001032180.1  NP_001027351.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HTA21 histone H2A 2 64.29(n)
    77.78(a)    		   828831  NM_001203923.1  NP_001190852.1 
    rice
    (Oryza sativa)    		 Liliopsida Os07g05454001 hypothetical protein 68.89(n)
    78.33(a)    		   4343519  NM_001066450.1  NP_001059915.1 


    ENSEMBL Gene Tree for HIST2H2AB (if available)
    TreeFam Gene Tree for HIST2H2AB (if available) 

    Paralogs
    for HIST2H2AB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H2AB gene
    HIST3H2A2  HIST1H2AD2  HIST2H2AA32  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  HIST1H2AH2  
    HIST1H2AM2  HIST1H2AJ2  HIST2H2AA42  HIST1H2AE2  HIST2H2AC2  HIST1H2AB2  HIST1H2AK2  HIST1H2AL2  
    H2AFJ2  
    18/26 SIMAP similar genes for HIST2H2AB using alignment to 1 protein entry:     H2A2B_HUMAN(see all similar genes):
    HIST1H2AA    H2AFJ    H2AFX    HIST1H2AB    HIST1H2AC    HIST1H2AD
    HIST1H2AE    HIST1H2AG    HIST1H2AI    HIST1H2AK    HIST1H2AL    HIST1H2AM
    HIST2H2AA3    HIST2H2AA4    HIST2H2AC    HIST3H2A    HIST1H2AH    HIST1H2AJ

    HIST2H2AB for paralogs           About GeneDecksing



    Genomic Variants
    for HIST2H2AB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11 NCBI SNPs in HIST2H2AB are shown (see all 11)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1154418641,2
    		C,F,--149860319(+) GTCTTA/GCCCAT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs175815971,2
    		C,F,H,--149860372(+) AGACCC/TTTATG 1 -- us2k116Minor allele frequency- T:0.15NA NS EA 1858
    rs1812570171,2
    		--149860404(+) TCAACC/GTACTT 1 -- us2k10--------
    rs741240421,2
    		C,--149860465(+) GAACTC/GATACA 1 -- us2k12Minor allele frequency- G:0.05WA 120
    rs1869314991,2
    		--149860516(+) AGCATA/CCTTAC 1 -- us2k10--------
    rs771327021,2
    		C,--149860908(+) GTGGGT/CTTTTT 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs1917662961,2
    		--149860917(+) TTGTTC/TGTTTT 1 -- us2k10--------
    rs750618241,2
    		--149860949(+) CACCCA/GGGCTG 1 -- us2k10--------
    rs1995899901,2
    		--149860962(+) GCACT-/ATCTCA 1 -- us2k10--------
    rs1137105881,2
    		C,--149861027(+) TCAAGC/TGATCC 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for HIST2H2AB (149859019 - 149859466 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HIST2H2AB
         3 CNVs: 3313 2326 8329
         1 Inversion: 37081

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    Disorders / Diseases
    for HIST2H2AB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST2H2AB for disorders           About GeneDecksing

    OMIM gene information: 615014    OMIM disorders: --

    5 diseases for HIST2H2AB:    About MalaCards
    x inactivation    riddle syndrome    systemic lupus erythematosus    lupus erythematosus
    immunodeficiency


    Export disorders for HIST2H2AB gene to outside databases

    Publications
    for HIST2H2AB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H2AB gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with HIST2H2AB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (2005)
    5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    6. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
    7. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (2004)
    8. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (2004)
    9. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (2012)
    10. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (2012)

    External Searches for HIST2H2AB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST2H2AB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 317772 HGNC: 20508 AceView: HIST2H2AB Ensembl:ENSG00000184270 euGenes: HUgn317772
    ECgene: HIST2H2AB Kegg: 317772 H-InvDB: HIST2H2AB

    Other Databases showing HIST2H2AB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST2H2AB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H2AB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST2H2AB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST2H2AB gene:
    Search GeneIP for patents involving HIST2H2AB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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