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HIST2H2AA4 Gene

protein-coding   GIFtS: 44
GCID: GC01P149822

Histone Cluster 2, H2aa4

(Previous names: histone 2, H2aa4)
  Search for HIST2H2AA4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 2, H2aa41 2     H2AFO3
Histone 2, H2aa41 2     HIST2H2AA3
H2A/R2     Histone H2A.23
Histone H2A Type 2-A2     Histone H2A/O3
Histone H2A/R2     

External Ids:    HGNC: 296681   Entrez Gene: 7237902   Ensembl: ENSG000002038127   UniProtKB: Q6FI133   

Export aliases for HIST2H2AA4 gene to outside databases

Previous GC identifers: GC01P148089 GC01M121196


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST2H2AA4 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in a histone cluster on
chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents
the telomeric copy. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST2H2AA4 Gene:
HIST2H2AA4 (histone cluster 2, H2aa4) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HIST2H2AA4 gene promoter:
         AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   E47   Egr-4   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HIST2H2AA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H2AA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2AA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2AA4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149822:  view genomic region     (about GC identifiers)

Start:
149,822,628 bp from pter      End:
149,823,191 bp from pter
Size:
564 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13 (See protein sequence)
Recommended Name: Histone H2A type 2-A  
Size: 130 amino acids; 14095 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Mass spectrometry: Mass=13997.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: B2R5F0 P20670

Explore the universe of human proteins at neXtProt for HIST2H2AA4: NX_Q6FI13

Explore proteomics data for HIST2H2AA4 at MOPED

Post-translational modifications: 

  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly
    represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at
    Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates
    their transcription1
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at
    35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys14, Lys16, Lys96, Lys100, Lys119
  • Modification sites at PhosphoSitePlus

  • See HIST2H2AA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001035807.1  
    ENSEMBL proteins: 
     ENSP00000358155  
    Reactome Protein details: Q6FI13

    HIST2H2AA4 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for HIST2H2AA4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q6FI13

    ProtoNet protein and cluster: Q6FI13

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13
    Similarity: Belongs to the histone H2A family


    Find genes that share domains with HIST2H2AA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A2A_HUMAN, Q6FI13
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST2H2AA4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST2H2AA4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST2H2AA4

    miRNA
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    miRTarBase miRNAs that target HIST2H2AA4:
    hsa-mir-34a-5p (MIRT025486)

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    3 qRT-PCR Assays for microRNAs that regulate HIST2H2AA4:
    hsa-miR-146a* hsa-miR-1276 hsa-miR-1293
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    Inhib. RNA
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    Sino Biological Human cDNA Clone for HIST2H2AA4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2A2A_HUMAN, Q6FI13: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with HIST2H2AA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST2H2AA4 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Chromosome Maintenance0.62
    Meiotic Synapsis0.66
    Nucleosome assembly0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Telomere Maintenance0.64
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with HIST2H2AA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Reactome Pathways for HIST2H2AA4 (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    2 Kegg Pathways  (Kegg details for HIST2H2AA4):
        Alcoholism
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST2H2AA4
    Interactions:

        Search GeneGlobe Interaction Network for HIST2H2AA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST2H2AA4 (Q6FI133 ENSP000003581554) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    G3BP1Q132833, ENSP000003485784I2D: score=2 STRING: ENSP00000348578
    CHD1LQ86WJ13, ENSP000003582624I2D: score=1 STRING: ENSP00000358262
    BMI1P352263I2D: score=1 
    DNAJC2Q995433I2D: score=1 
    GRB2P629933I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    Find genes that share ontologies with HIST2H2AA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST2H2AA4 (H2A2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST2H2AA4 gene: 
    NM_001040874.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369159(uc001esx.3)
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      Search QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2AA4
      QuantiFast Probe-based Assays in human, mouse, rat HIST2H2AA4

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST2H2AA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST2H2AA4 Expression
    About this image


    HIST2H2AA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    HIST2H2AA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST2H2AA4 Protein Expression
        Custom PCR Arrays for HIST2H2AA4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2AA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIST2H2AA4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2al5
    Hist2h2aa11
    histone cluster 1, H2al5
    histone cluster 2, H2aa11
    89.49(n)1
    100(a)1
      13 (26.09 cM)5
    152671  NM_013549.11  NP_038577.11 
     512026885 
    chicken
    (Gallus gallus)
    Aves H2A-VII6
    Gallus gallus histone cluster 1, H2A, IV (similar ...
    98(a)
    many ↔ many
    1(47928677-47994976)


    ENSEMBL Gene Tree for HIST2H2AA4 (if available)
    TreeFam Gene Tree for HIST2H2AA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST2H2AA4 gene
    HIST2H2AA31 2  HIST3H2A2  HIST1H2AD2  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST1H2AA2  HIST1H2AE2  HIST1H2AB2  HIST2H2AC2  HIST1H2AK2  
    HIST1H2AL2  H2AFJ2  
    Selected SIMAP similar genes for HIST2H2AA4 using alignment to 1 protein entry:     H2A2A_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH
    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST3H2A
    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX    HIST1H2APS4

    Find genes that share paralogs with HIST2H2AA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST2H2AA4 (see all 11)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121196011,2
    C,F,H--149820656(+) ACTATC/GTACAC 1 -- us2k116Minor allele frequency- G:0.28NS EA NA WA CSA 790
    rs757375341,2
    F--149820776(+) CACCAT/CTGCAC 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1457910871,2
    --149820819(+) CTTTAA/GCATAT 1 -- us2k10--------
    rs597937681,2
    C,F--149820836(+) ATCACC/GCAGAA 1 -- us2k13Minor allele frequency- G:0.06WA CSA 122
    rs1832215031,2
    C--149820893(+) TTCAAG/TTAATG 1 -- us2k10--------
    rs1384454191,2
    --149820909(+) GCTGCC/TGGTCT 1 -- us2k10--------
    rs727081461,2
    C,F--149821019(+) ATCCCC/TAGAGC 1 -- us2k11Minor allele frequency- T:0.05NA 120
    rs1852228421,2
    --149821210(+) AACTGC/GACAAG 1 -- us2k10--------
    rs1896498261,2
    --149821237(+) CTCTTA/GGGGAA 1 -- us2k10--------
    rs3728501261,2
    ----149820927(+) CTTTAA/CGTCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST2H2AA4 (149822628 - 149823191 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HIST2H2AA4 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469694CNV Loss16826518
    nsv428235CNV Gain18775914
    nsv831525CNV Gain17160897
    nsv872384CNV Gain21882294
    nsv824564CNV Gain20364138
    nsv831503CNV Gain17160897
    esv2750807CNV Gain17911159
    essv23032CNV CNV17122850
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST2H2AA4
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H2AA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    3 diseases from the University of Copenhagen DISEASES database for HIST2H2AA4:
    Lupus erythematosus     Connective tissue disease     Cleft palate

    Find genes that share disorders with HIST2H2AA4           About GenesLikeMe


    Export disorders for HIST2H2AA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for HIST2H2AA4 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with HIST2H2AA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 3 Braastad C.D....Stein G.S. (Gene 2004)
    2. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    3. The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PubMed id 8179821)1, 2 Mannironi C.... Bonner W. (DNA Cell Biol. 1994)
    4. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. (PubMed id 24352239)2 Tessarz P.... Kouzarides T. (Nature 2014)
    5. VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. (PubMed id 24140421)2 Kim K.... An W. (Mol. Cell 2013)
    6. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (Cell Cycle 2012)
    7. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (Cell 2011)
    10. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 723790 HGNC: 29668 Ensembl:ENSG00000203812 euGenes: HUgn723790 ECgene: HIST2H2AA4 Kegg: 723790
    H-InvDB: HIST2H2AA4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST2H2AA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HIST2H2AA4 gene:
    Search GeneIP for patents involving HIST2H2AA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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