HIST2H2AA4 Gene
protein-coding GIFtS: 44
GCID: GC01P149822
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histone cluster 2, H2aa4(Previous names: histone 2, H2aa4 )
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Aliases
for HIST2H2AA4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Histone Cluster 2, H2aa41 2 | | Histone H2A/R2 | | Histone 2, H2aa41 2 | | H2AFO3 | | H2A/R2 | | HIST2H2AA3 | | H2A/R2 | | Histone H2A.23 | | Histone H2A Type 2-A2 | | Histone H2A/O3 |
Export aliases for HIST2H2AA4 gene to outside databasesPrevious GC identifers: GC01P148089 GC01M121196 |
Summaries
for HIST2H2AA4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIST2H2AA4:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber ineukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around whichapproximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts withlinker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene isintronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but insteadcontain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is oneof four histone genes in the cluster that are duplicated; this record represents the telomeric copy. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling
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Genomic Views
for HIST2H2AA4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIST2H2AA4 gene promoter:
AP-2alpha isoform 3 Nkx2-5 AP-2alpha isoform 2 E47 Egr-4 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIST2H2AA4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H2AA4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.2HIST2H2AA4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P149822: view genomic region
(about GC identifiers)
Start:
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149,822,628 bp from pter |
End:
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149,823,191 bp from pter |
Size:
|
564 bases |
Orientation:
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plus strand |
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Proteins
for HIST2H2AA4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13 (See
protein sequence)Recommended Name: Histone H2A type 2-A Size: 130 amino acids; 14095 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=13997.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;Source=PubMed:16457589;
Secondary accessions: B2R5F0 P20670Explore the universe of human proteins at neXtProt for HIST2H2AA4: NX_Q6FI13
Post-translational modifications:
The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
Deiminated on Arg-4 in granulocytes upon calcium entry1
Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetictranscriptional repression and participates in X chromosome inactivation of female mammals. It is involved in theinitiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosomechromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub byRNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks(DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligasesRNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 andLys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediatesmonoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is ableto extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linkedubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly repressestranscription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (Bysimilarity)1
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks activepromoters and enhancers and confers resistance to transcriptional repressors. It is also associated withpost-meiotically activated genes on autosomes1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6FI13
HIST2H2AA4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035807.1
ENSEMBL proteins: ENSP00000358155 Reactome Protein details: Q6FI13
Human Recombinant Protein Products for HIST2H2AA4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HIST2H2AA4 for ontologies About GeneDecksing
HIST2H2AA4 Antibody Products:
Assay Products for HIST2H2AA4: |
Protein
Domains /
Families
for HIST2H2AA4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIST2H2AA4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6FI13ProtoNet protein and cluster: Q6FI13 1 Blocks protein family: IPB002119 Histone H2A
UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13Similarity: Belongs to the histone H2A family |
Function
for HIST2H2AA4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: H2A2A_HUMAN, Q6FI13Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IEA | -- |
HIST2H2AA4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H2AA4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H2AA4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HIST2H2AA4 (NM_001040874) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIST2H2AA4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2AA4 |
|
Pathways & Interactions
for HIST2H2AA4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Meiotic Synapsis | | | 2 | RSF Complex Binds the Centromere. | | | 3 | Disease | | | 4 | Systemic lupus erythematosus | | | 5 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/14 
Reactome Pathways for HIST2H2AA4 (see all 14)
1 
Kegg Pathway (Kegg details for HIST2H2AA4):
HIST2H2AA4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H2AA4
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/17 Interacting proteins for HIST2H2AA4 (Q6FI133 ENSP000003581554) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- |
HIST2H2AA4 for ontologies About GeneDecksing
|
Drugs & Compounds
for HIST2H2AA4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HIST2H2AA4
Search CenterWatch for drugs/clinical trials and news about HIST2H2AA4 / H2A2A
|
Transcripts
for HIST2H2AA4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIST2H2AA4 gene: NM_001040874.1 Unigene Cluster for HIST2H2AA4: Histone cluster 2, H2aa4 Hs.530461 Unigene Representative Sequence: BC0016291 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000369159(uc001esx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H2AA4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H2AA4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HIST2H2AA4 (NM_001040874) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIST2H2AA4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2AA4 |
Additional cDNA sequence: AK312163.1 BC001629.1 BC019308.1 BC096705.1 BC096739.1 BC098171.1 CR536525.1 CR541872.1 L19779.1 3 DOTS entries: DT.97841824 DT.315631 DT.97841825
GeneLoc Exon Structure
|
Expression
for HIST2H2AA4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIST2H2AA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HIST2H2AA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIST2H2AA4
SOURCE GeneReport for Unigene cluster: Hs.530461
SABiosciences Custom PCR Arrays for HIST2H2AA4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST2H2AA4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIST2H2AA4 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2AA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST2H2AA4 |
Orthologs
for HIST2H2AA4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HIST2H2AA4 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for HIST2H2AA4 (if available)
TreeFam Gene Tree for HIST2H2AA4 (if available) |
Paralogs
for HIST2H2AA4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIST2H2AA4 gene
- HIST2H2AA31 2 HIST3H2A2 HIST1H2AD2 HIST2H2AB2 H2AFX2 HIST1H2AI2 HIST1H2AG2 HIST1H2AC2
- HIST1H2AH2 HIST1H2AM2 HIST1H2AJ2 HIST1H2AE2 HIST2H2AC2 HIST1H2AB2 HIST1H2AK2 HIST1H2AL2
- H2AFJ2
18/25 SIMAP similar genes for HIST2H2AA4 using alignment to 1 protein entry: H2A2A_HUMAN(see all similar genes):HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH
HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST3H2A
H2AFJ HIST1H2AA HIST2H2AB HIST2H2AC H2AFX HIST1H2APS4
HIST2H2AA4 for paralogs About GeneDecksing
|
Genomic Variants
for HIST2H2AA4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIST2H2AA4 (149822628 - 149823191 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for HIST2H2AA4
6 CNVs: 3313 2326 48130 4255 2052 8329
3 Inversions: 0391 37081 37080 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST2H2AA4 |
|
Disorders
/ Diseases
for HIST2H2AA4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIST2H2AA4 for disorders About GeneDecksing
5  diseases for HIST2H2AA4: About MalaCardsconnective tissue disease x inactivation riddle syndrome systemic lupus erythematosus
lupus erythematosus
3 diseases from the University of Copenhagen DISEASES database for HIST2H2AA4:Lupus erythematosus Connective tissue disease Cleft palate Export disorders for HIST2H2AA4 gene to outside databases
|
Publications
for HIST2H2AA4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIST2H2AA4 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with HIST2H2AA4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 3 Braastad C.D....Stein G.S. (2004)
- The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2 Marzluff W.F....Maltais L.J. (2002)
- The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PubMed id 8179821)1, 2 Mannironi C.... Bonner W. (1994)
- A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (2012)
- RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. (PubMed id 19203579)2 Doil C.... Lukas C. (2009)
- The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. (PubMed id 19203578)2 Stewart G.S....Durocher D. (2009)
|
External Searches for HIST2H2AA4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIST2H2AA4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIST2H2AA4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIST2H2AA4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HIST2H2AA4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HIST2H2AA4 gene:
Search GeneIP for patents involving HIST2H2AA4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIST2H2AA4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HIST2H2AA4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST2H2AA4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST2H2AA4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIST2H2AA4 | | OriGene 3'-UTR Clone for HIST2H2AA4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H2AA4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST2H2AA4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIST2H2AA4 | | OriGene Custom Protein Services for HIST2H2AA4 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST2H2AA4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST2H2AA4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H2AA4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST2H2AA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST2H2AA4 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2AA4 |
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 | | | HIST2H2AA4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2AA4 |
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