Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIST2H2AA3 Gene

protein-coding   GIFtS: 52
GCID: GC01M149813

Histone Cluster 2, H2aa3

(Previous names: H2A histone family, member O, histone 2, H2aa, histone 2,...)
(Previous symbols: H2AFO, HIST2H2AA)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histone Cluster 2, H2aa31 2     H2A.22
H2AFO1 2 3 5     H2A/O2
HIST2H2AA1 2 3 5     H2A/q2
H2A Histone Family, Member O1 2     H2a-6152
Histone 2, H2aa31 2     Histone H2A Type 2-A2
H2A2 5     Histone H2A.23
Histone 2, H2aa1     Histone H2A/O3

External Ids:    HGNC: 47361   Entrez Gene: 83372   Ensembl: ENSG000001835587   OMIM: 1427205   UniProtKB: Q6FI133   

Export aliases for HIST2H2AA3 gene to outside databases

Previous GC identifers: GC01M148080 GC01P121205


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIST2H2AA3 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in a histone cluster on
chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents
the centromeric copy. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST2H2AA3 Gene:
HIST2H2AA3 (histone cluster 2, H2aa3) is a protein-coding gene. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST2H2AA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST2H2AA3 gene promoter:
         AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   E47   Egr-4   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST2H2AA3 promoter sequence
   Search Chromatin IP Primers for HIST2H2AA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H2AA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2AA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2AA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149813:  view genomic region     (about GC identifiers)

Start:
149,813,505 bp from pter      End:
149,814,478 bp from pter
Size:
974 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13 (See protein sequence)
Recommended Name: Histone H2A type 2-A  
Size: 130 amino acids; 14095 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Mass spectrometry: Mass=13997.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: B2R5F0 P20670

Explore the universe of human proteins at neXtProt for HIST2H2AA3: NX_Q6FI13

Explore proteomics data for HIST2H2AA3 at MOPED

Post-translational modifications: 

  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly
    represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at
    Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates
    their transcription1
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at
    35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST2H2AA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003507.1  
    ENSEMBL proteins: 
     ENSP00000358158  
    Reactome Protein details: Q6FI13

    HIST2H2AA3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HIST2H2AA3
    GenScript Custom Purified and Recombinant Proteins Services for HIST2H2AA3
    Novus Biologicals HIST2H2AA3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST2H2AA3

     
    Search eBioscience for Proteins for HIST2H2AA3 

     
    antibodies-online proteins for HIST2H2AA3 (4 products) 

     
    antibodies-online peptides for HIST2H2AA3

    HIST2H2AA3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST2H2AA3
    Novus Biologicals HIST2H2AA3 Antibodies
    Abcam antibodies for HIST2H2AA3
    Cloud-Clone Corp. Antibodies for HIST2H2AA3
    Search ThermoFisher Antibodies for HIST2H2AA3
    antibodies-online antibodies for HIST2H2AA3 (14 products) 

    HIST2H2AA3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIST2H2AA3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST2H2AA3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST2H2AA3
    Cloud-Clone Corp. CLIAs for HIST2H2AA3
    Search eBioscience for ELISAs for HIST2H2AA3 
    antibodies-online kits for HIST2H2AA3 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q6FI13

    ProtoNet protein and cluster: Q6FI13

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13
    Similarity: Belongs to the histone H2A family


    Find genes that share domains with HIST2H2AA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A2A_HUMAN, Q6FI13
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity ----
         
    Find genes that share ontologies with HIST2H2AA3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HIST2H2AA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST2H2AA3:
    hsa-mir-100-5p (MIRT048399), hsa-mir-320a (MIRT044615), hsa-mir-25-3p (MIRT050242), hsa-mir-671-5p (MIRT039268), hsa-mir-193b-3p (MIRT041606), hsa-mir-92a-3p (MIRT049338), hsa-mir-34a-5p (MIRT025387), hsa-mir-18a-3p (MIRT040781), hsa-mir-940 (MIRT036592), hsa-mir-26a-5p (MIRT050188), hsa-mir-17-5p (MIRT050850), hsa-mir-424-5p (MIRT042440), hsa-mir-149-5p (MIRT045401), hsa-mir-615-3p (MIRT039626), hsa-mir-2277-5p (MIRT052846), hsa-mir-744-5p (MIRT037476), hsa-mir-320c (MIRT036169), hsa-mir-425-3p (MIRT042417)

    Block miRNA regulation of human, mouse, rat HIST2H2AA3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate HIST2H2AA3:
    hsa-miR-146a* hsa-miR-1276 hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIST2H2AA3
    Predesigned siRNA for gene silencing in human, mouse, rat HIST2H2AA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST2H2AA3

    Clone
    Products:
         
    OriGene clones in human, mouse for HIST2H2AA3 (see all 8)
    OriGene ORF clones in mouse, rat for HIST2H2AA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST2H2AA3 (NM_003516)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST2H2AA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2AA3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST2H2AA3
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIST2H2AA3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2AA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    H2A2A_HUMAN, Q6FI13: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005622intracellular ----
    GO:0005634nucleus ----

    Find genes that share ontologies with HIST2H2AA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HIST2H2AA3 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Chromosome Maintenance0.62
    Meiotic Synapsis0.66
    Nucleosome assembly0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Telomere Maintenance0.64
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with HIST2H2AA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for HIST2H2AA3 (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    2 Kegg Pathways  (Kegg details for HIST2H2AA3):
        Alcoholism
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST2H2AA3
    Interactions:

        Search GeneGlobe Interaction Network for HIST2H2AA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST2H2AA3 (Q6FI133 ENSP000003581584) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMI1P352263, ENSP000003658514I2D: score=1 STRING: ENSP00000365851
    DNAJC2Q995433, ENSP000003685654I2D: score=1 STRING: ENSP00000368565
    RCC1P187543, ENSP000003629374I2D: score=1 STRING: ENSP00000362937
    RNF2Q994963, ENSP000003564804I2D: score=1 STRING: ENSP00000356480
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----

    Find genes that share ontologies with HIST2H2AA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST2H2AA3 (H2A2A)

    1 HMDB Compound for HIST2H2AA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIST2H2AA3 gene: 
    NM_003516.2  

    Unigene Cluster for HIST2H2AA3:

    Histone cluster 2, H2aa3
    Hs.530461  [show with all ESTs]
    Unigene Representative Sequence: BM044061
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369161(uc001esw.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIST2H2AA3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate HIST2H2AA3:
    hsa-miR-146a* hsa-miR-1276 hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIST2H2AA3
    Predesigned siRNA for gene silencing in human, mouse, rat HIST2H2AA3
    Clone
    Products:
         
    OriGene clones in human, mouse for HIST2H2AA3 (see all 8)
    OriGene ORF clones in mouse, rat for HIST2H2AA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST2H2AA3 (NM_003516)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST2H2AA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2AA3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HIST2H2AA3
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST2H2AA3
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HIST2H2AA3
      QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2AA3
      QuantiFast Probe-based Assays in human, mouse, rat HIST2H2AA3

    Additional mRNA sequence: 

    AK312163.1 BC001629.1 BC019308.1 BC096705.1 BC096739.1 BC098171.1 CR536525.1 CR541872.1 
    L19779.1 

    8 DOTS entries:

    DT.97841824  DT.97841825  DT.315631  DT.100025565  DT.100678668  DT.87014780  DT.87015210  DT.92044741 

    Selected AceView cDNA sequences (see all 135):

    AI520698 BC019308 L19779 BE208521 CR536525 F24112 AW051535 AI760363 
    CR541872 BQ959893 BF476365 AI318664 BM693451 BM352101 AI252455 AI885388 
    BE887834 BC001629 NM_003516 BU623115 AI205896 BM694433 BU785349 CA774860 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIST2H2AA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGCGGTCC
    HIST2H2AA3 Expression
    About this image


    HIST2H2AA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    HIST2H2AA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST2H2AA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530461
        Custom PCR Arrays for HIST2H2AA3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HIST2H2AA3
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST2H2AA3
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HIST2H2AA3
    QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2AA3
    QuantiFast Probe-based Assays in human, mouse, rat HIST2H2AA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2AA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for HIST2H2AA3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist2h2aa11 , 5 histone cluster 2, H2aa11, 5 89.49(n)1
    100(a)1
      3 (41.69 cM)5
    152671  NM_013549.11  NP_038577.11 
     962454975 
    chicken
    (Gallus gallus)
    Aves H2A-VII6
    Histone H2A-IV
    98(a)
    many ↔ many
    1(48016719-48017108)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii CB492861.12   -- 80.16(n)    CB492861.1 


    ENSEMBL Gene Tree for HIST2H2AA3 (if available)
    TreeFam Gene Tree for HIST2H2AA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIST2H2AA3 gene
    HIST2H2AA41 2  HIST3H2A2  HIST1H2AD2  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST1H2AA2  HIST1H2AE2  HIST1H2AB2  HIST2H2AC2  HIST1H2AK2  
    HIST1H2AL2  H2AFJ2  
    Selected SIMAP similar genes for HIST2H2AA3 using alignment to 1 protein entry:     H2A2A_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH
    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST3H2A
    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX    HIST1H2APS4

    Find genes that share paralogs with HIST2H2AA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIST2H2AA3 (see all 30)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809471301,2
    --149815060(+) CTCCAA/GAGGCT 1 -- us2k10--------
    rs1407198791,2
    --149815073(+) TTTCAG/TGGCCA 1 -- us2k10--------
    rs23189761,2
    C,H--149815079(+) GGCCAC/TTTAAC 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 418
    rs1502590771,2
    --149815120(+) GCTTAC/TTGTGA 1 -- us2k10--------
    rs1851537341,2
    --149815136(+) ACTTAA/GGGGTT 1 -- us2k10--------
    rs1886908101,2
    --149815150(+) CCTCAA/GCACCT 1 -- us2k10--------
    rs782299841,2
    F--149815239(+) GTGACA/GGGGTC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1390279661,2
    --149815241(+) GACAGC/GGTCAT 1 -- us2k10--------
    rs37383191,2
    C,F,H--149815323(-) TCCCTC/TGACTC 1 -- us2k1 trp319Minor allele frequency- T:0.15EA NS NA WA 3826
    rs75316641,2
    C,F,A,H--149815536(+) TTATTT/CCTGGG 1 -- us2k123Minor allele frequency- C:0.24NS EA NA WA CSA 2317

    HapMap Linkage Disequilibrium report for HIST2H2AA3 (149813505 - 149814478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HIST2H2AA3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469694CNV Loss16826518
    nsv428235CNV Gain18775914
    nsv831525CNV Gain17160897
    nsv872384CNV Gain21882294
    nsv824564CNV Gain20364138
    nsv831503CNV Gain17160897
    esv2750807CNV Gain17911159
    essv23032CNV CNV17122850
    dgv117e1CNV Complex17122850
    dgv125e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST2H2AA3
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST2H2AA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 142720    OMIM disorders: --

    3 diseases from the University of Copenhagen DISEASES database for HIST2H2AA3:
    Lupus erythematosus     Connective tissue disease     Cleft palate

    Find genes that share disorders with HIST2H2AA3           About GenesLikeMe


    Export disorders for HIST2H2AA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIST2H2AA3 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with HIST2H2AA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PubMed id 8179821)1, 2, 3 Mannironi C.... Bonner W. (DNA Cell Biol. 1994)
    2. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)1, 2 Mattiroli F.... Sixma T.K. (Cell 2012)
    3. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (J. Proteome Res. 2006)
    4. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (Genes Dev. 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (Mol. Cell 2005)
    7. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (Biochemistry 2005)
    8. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (J. Biol. Chem. 2004)
    9. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (Nature 2004)
    10. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 3 Braastad C.D....Stein G.S. (Gene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8337 HGNC: 4736 AceView: HIST2H2AA Ensembl:ENSG00000183558 euGenes: HUgn8337
    ECgene: HIST2H2AA3 Kegg: 8337 H-InvDB: HIST2H2AA3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIST2H2AA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIST2H2AA3 gene:
    Search GeneIP for patents involving HIST2H2AA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HIST2H2AA3  
     OriGene qPCR primer pairs and template standards for HIST2H2AA3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HIST2H2AA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIST2H2AA3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HIST2H2AA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST2H2AA3   OriGene Custom Protein Services for HIST2H2AA3  

     
     
     Block miRNA regulation of human, mouse, rat HIST2H2AA3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIST2H2AA3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST2H2AA3 Predesigned siRNA for gene silencing in human, mouse, rat HIST2H2AA3
     QuantiFast Probe-based Assays in human, mouse, rat HIST2H2AA3 QuantiTect SYBR Green Assays in human, mouse, rat HIST2H2AA3
     Custom PCR Arrays for HIST2H2AA3 Search Chromatin IP Primers for HIST2H2AA3
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HIST2H2AA3 Search GeneGlobe Interaction Network for HIST2H2AA3
     Regulatory tfbs in HIST2H2AA3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIST2H2AA3 GenScript cDNA clones with any tag delivered in your preferred vector for HIST2H2AA3
     GenScript Custom Assay Services for HIST2H2AA3 GenScript Custom overexpressing Cell Line Services for HIST2H2AA3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HIST2H2AA3 (H2A2A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HIST2H2AA3 antibodies
     HIST2H2AA3 proteins
     Antibodies for HIST2H2AA3
     See all of Abcam's Antibodies, Kits and Proteins for HIST2H2AA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIST2H2AA3
     Antibodies for HIST2H2AA3
     ELISAs for HIST2H2AA3
     CLIAs for HIST2H2AA3



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIST2H2AA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST2H2AA3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST2H2AA3
     SwitchGear Promoter luciferase reporter plasmids for HIST2H2AA3
     Search ThermoFisher Antibodies for HIST2H2AA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST2H2AA3
     Browse compounds at ApexBio
     Search Addgene for plasmids for HIST2H2AA3
      Search eBioscience for proteins for HIST2H2AA3
      Search eBioscience for elisas for HIST2H2AA3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HIST2H2AA3
     antibodies-online antibodies for HIST2H2AA3 (14 products)
     antibodies-online kits for HIST2H2AA3 (2 products)
     antibodies-online peptides for HIST2H2AA3
     antibodies-online proteins for HIST2H2AA3 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST2H2AA3 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4