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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST2H2AA3 Gene

protein-coding   GIFtS: 52
GCID: GC01M149813

histone cluster 2, H2aa3

(Previous names: H2A histone family, member O, histone 2, H2aa, histone...)
(Previous symbols: H2AFO, HIST2H2AA)
 Explore 6 diseases affiliated with
HIST2H2AA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST2H2AA3    

Aliases
for HIST2H2AA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 2, H2aa31 2     H2A2 5
H2AFO1 2 3 5     Histone 2, H2aa1
HIST2H2AA1 2 3 5     H2A/O2
H2A.21 2     H2a-6152
H2A/Q1     Histone H2A Type 2-A2
H2A Histone Family, Member O1 2     Histone H2A.23
Histone 2, H2aa31 2     Histone H2A/O3

External Ids:    HGNC: 47361   Entrez Gene: 83372   Ensembl: ENSG000001835587   OMIM: 1427205   UniProtKB: Q6FI133   

Export aliases for HIST2H2AA3 gene to outside databases

Previous GC identifers: GC01M148080 GC01P121205


Summaries
for HIST2H2AA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST2H2AA3:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one
of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H2AA3


Genomic Views
for HIST2H2AA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H2AA3 gene promoter:
         AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   E47   Egr-4   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST2H2AA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST2H2AA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST2H2AA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2AA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2AA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149813:  view genomic region     (about GC identifiers)

Start:
 149,813,505 bp from pter      End:
 149,814,478 bp from pter
Size:
 974 bases      Orientation:
 minus strand

Proteins
for HIST2H2AA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13 (See protein sequence)
Recommended Name: Histone H2A type 2-A  
Size: 130 amino acids; 14095 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=13997.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: B2R5F0 P20670

Explore the universe of human proteins at neXtProt for HIST2H2AA3: NX_Q6FI13

Post-translational modifications:

  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    • transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by
    RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks
    (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases
    RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and
    Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates
    monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able
    to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked
    ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    • similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6FI13

    • HIST2H2AA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003507.1  
    ENSEMBL proteins: 
     ENSP00000358158  
    Reactome Protein details: Q6FI13
    Human Recombinant Protein Products: 
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    Uscn Proteins for HIST2H2AA3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005634nucleus ----


    HIST2H2AA3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HIST2H2AA3

    Protein Domains /
    Families
    for HIST2H2AA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST2H2AA3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q6FI13

    ProtoNet protein and cluster: Q6FI13

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13
    Similarity: Belongs to the histone H2A family


    Function
    for HIST2H2AA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2A2A_HUMAN, Q6FI13
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
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    OriGene shRNA RFP: HIST2H2AA3
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIST2H2AA3

    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----


    HIST2H2AA3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST2H2AA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Systemic lupus erythematosus
    		Systemic lupus erythematosus1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/14        Reactome Pathways for HIST2H2AA3 (see all 14)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Deposition of New CENPA-containing Nucleosomes at the Centromere


    1         Kegg Pathway  (Kegg details for HIST2H2AA3):
        Systemic lupus erythematosus


    HIST2H2AA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H2AA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/20 Interacting proteins for HIST2H2AA3 (Q6FI133 ENSP000003581584) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMI1P352263, ENSP000003658514I2D: score=1 STRING: ENSP00000365851
    DNAJC2Q995433, ENSP000003685654I2D: score=1 STRING: ENSP00000368565
    RCC1P187543, ENSP000003629374I2D: score=1 STRING: ENSP00000362937
    RNF2Q994963, ENSP000003564804I2D: score=1 STRING: ENSP00000356480
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----


    HIST2H2AA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST2H2AA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H2AA3

    1 HMDB Compound for HIST2H2AA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about HIST2H2AA3 / H2A2A 

    Transcripts
    for HIST2H2AA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST2H2AA3 gene: 
    NM_003516.2  

    Unigene Cluster for HIST2H2AA3:

    Histone cluster 2, H2aa3
    Hs.741531  [show with all ESTs]
    Unigene Representative Sequence: BM044061
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369161(uc001esw.3)

    miRNA
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    hsa-miR-146a* hsa-miR-1276 hsa-miR-1293
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    Inhib. RNA
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    Clone
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    Primer
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    8 DOTS entries:

    DT.97841825  DT.97841824  DT.315631  DT.100025565  DT.100678668  DT.87014780  DT.87015210  DT.92044741 

    24/135 AceView cDNA sequences (see all 135):

    BM352101 AW051535 CR541872 AI760363 BC001629 NM_003516 AI318664 F24112 
    BQ959893 BM693451 L19779 AI252455 BF476365 BE208521 BE887834 BC019308 
    AI885388 CR536525 AI520698 BG026820 CA774860 AJ713309 AI292087 BG928607 

    GeneLoc Exon Structure


    Expression
    for HIST2H2AA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST2H2AA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGCGGTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST2H2AA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST2H2AA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST2H2AA3

    SOURCE GeneReport for Unigene cluster: Hs.741531
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST2H2AA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST2H2AA3 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H2A4_CHICK6
    H2A4_CHICK6
    (see all 8)    		 Histone H2A-IV
    (see all 8)    		 98(a)
    98(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 1(49943674-49944063)
    Un(7741023-7741412)
    lizard
    (Anolis carolinensis)    		 Reptilia HIST1H2AA6
    --
    (see all 3)    		 --
    		 99(a)
    83(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 GL343252.1(1827542-1827931)
    GL343252.1(1819594-1819782)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1018466
    CR354435.56
    (see all 31)    		 --
    		 94(a)
    93(a)
    (see all 31)    		 1 ↔ many
    possible ortholog
    (see all 31)    		 10(30724444-30725341)
    25(37377991-37378377)
    fruit fly
    (Drosophila melanogaster)    		 Insecta His2A:CG338236
    His2A:CG338356
    (see all 20)    		 His2A:CG33835
    (see all 20)    		 88(a)
    88(a)
    (see all 20)    		 possible ortholog
    possible ortholog
    (see all 20)    		 2L(21468115-21468683)
    2L(21488395-21488963)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 Core histone H2A/H2B/H3/H4 domain containing prote...
    		 15(a)
    		 1 → many
    		 4(7540547-7546903)


    ENSEMBL Gene Tree for HIST2H2AA3 (if available)
    TreeFam Gene Tree for HIST2H2AA3 (if available) 

    Paralogs
    for HIST2H2AA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST2H2AA3 gene
    HIST2H2AA41 2  HIST3H2A2  HIST1H2AD2  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST1H2AE2  HIST2H2AC2  HIST1H2AB2  HIST1H2AK2  HIST1H2AL2  
    H2AFJ2  
    18/25 SIMAP similar genes for HIST2H2AA3 using alignment to 1 protein entry:     H2A2A_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH
    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST3H2A
    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX    HIST1H2APS4

    HIST2H2AA3 for paralogs           About GeneDecksing



    Genomic Variants
    for HIST2H2AA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/25 NCBI SNPs in HIST2H2AA3 are shown (see all 25)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2001385301,2
    		--149813866(+) CGGACA/GTCAGC 2 -- ut31 us2k10--------
    rs577869601,2
    		C,--149815014(+) CCTCC-/CTCC  
                GCGGG     		1 -- us2k10--------
    rs1809471301,2
    		--149815060(+) CTCCAA/GAGGCT 1 -- us2k10--------
    rs1407198791,2
    		--149815073(+) TTTCAG/TGGCCA 1 -- us2k10--------
    rs23189761,2
    		C,H--149815079(+) GGCCAC/TTTAAC 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 418
    rs1502590771,2
    		--149815120(+) GCTTAC/TTGTGA 1 -- us2k10--------
    rs1851537341,2
    		--149815136(+) ACTTAA/GGGGTT 1 -- us2k10--------
    rs1886908101,2
    		--149815150(+) CCTCAA/GCACCT 1 -- us2k10--------
    rs782299841,2
    		F,--149815239(+) GTGACA/GGGGTC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1390279661,2
    		--149815241(+) GACAGC/GGTCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST2H2AA3 (149813505 - 149814478 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for HIST2H2AA3
         6 CNVs: 3313 2326 48130 4255 2052 8329
         3 Inversions: 0391 37081 37080

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    Disorders / Diseases
    for HIST2H2AA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST2H2AA3 for disorders           About GeneDecksing

    OMIM gene information: 142720    OMIM disorders: --

    6 diseases for HIST2H2AA3:    About MalaCards
    connective tissue disease    x inactivation    riddle syndrome    systemic lupus erythematosus
    lupus erythematosus    immunodeficiency

    3 diseases from the University of Copenhagen DISEASES database for HIST2H2AA3:
    Lupus erythematosus     Connective tissue disease     Cleft palate

    Export disorders for HIST2H2AA3 gene to outside databases

    Publications
    for HIST2H2AA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST2H2AA3 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with HIST2H2AA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PubMed id 8179821)1, 2, 3 Mannironi C.... Bonner W. (1994)
    2. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)1, 2 Mattiroli F.... Sixma T.K. (2012)
    3. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2 Bonenfant D.... van Oostrum J. (2006)
    4. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (2006)
    5. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (2005)
    8. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    9. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
    10. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 3 Braastad C.D....Stein G.S. (2004)

    External Searches for HIST2H2AA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing HIST2H2AA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8337 HGNC: 4736 AceView: HIST2H2AA Ensembl:ENSG00000183558 euGenes: HUgn8337
    ECgene: HIST2H2AA3 Kegg: 8337 H-InvDB: HIST2H2AA3

    Other Databases showing HIST2H2AA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST2H2AA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST2H2AA3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST2H2AA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST2H2AA3 gene:
    Search GeneIP for patents involving HIST2H2AA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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