Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H4J Gene

protein-coding   GIFtS: 52
GCID: GC06P027791

Histone Cluster 1, H4j

(Previous names: H4 histone family, member E, histone 1, H4j)
(Previous symbol: H4FE)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H4j1 2     H4/M3
H4FE1 2 3 5     H4/N3
H4 Histone Family, Member E1 2     H4/O3
Histone 1, H4j1 2     H4F23
H4/e2     H4FA3
H4F2iv2     H4FB3
dJ160A22.22     H4FC3
Histone H42     H4FD3
H4/A3     H4FG3
H4/B3     H4FH3
H4/C3     H4FI3
H4/D3     H4FJ3
H4/E3     H4FK3
H4/G3     H4FM3
H4/H3     H4FN3
H4/I3     H4FO3
H4/J3     HIST2H43
H4/K3     

External Ids:    HGNC: 47851   Entrez Gene: 83632   Ensembl: ENSG000001972387   OMIM: 6028265   UniProtKB: P628053   

Export aliases for HIST1H4J gene to outside databases

Previous GC identifers: GC06P027850 GC06P027899 GC06P027603


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H4J Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4J Gene: 
HIST1H4J (histone cluster 1, H4j) is a protein-coding gene. Diseases associated with HIST1H4J include non-hodgkin lymphoma, and hodgkin's lymphoma, and among its related super-pathways are Signal transduction Activin A signaling regulation and Development NOTCH1-mediated pathway for NF-KB activity modulation. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H4J gene promoter:
         NF-YA   AP-4   CUTL1   Egr-4   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H4J promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H4J

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H4J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4J gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027791:  view genomic region     (about GC identifiers)

Start:
27,791,884 bp from pter      End:
27,792,258 bp from pter
Size:
375 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST1H4J (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4J: NX_P62805

Explore proteomics data for HIST1H4J at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin
  • UniProtKB: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation
  • UniProtKB: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage
  • UniProtKB: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • UniProtKB: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H4
  • UniProtKB: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)
  • UniProtKB: Sumoylated, which is associated with transcriptional repression
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62805

  • HIST1H4J Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H4J Protein Expression
    REFSEQ proteins: NP_068803.1  
    ENSEMBL proteins: 
     ENSP00000347168  
    Reactome Protein details: P62805
    Human Recombinant Protein Products for HIST1H4J: 
    EMD Millipore Purified and/or Recombinant HIST1H4J Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HIST1H4J
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HIST1H4J
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H4J
    Novus Biologicals HIST1H4J Protein
    Novus Biologicals HIST1H4J Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H4J 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST1H4J for ontologies           About GeneDecksing



    HIST1H4J Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4J
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST1H4J
    GenScript Custom Superior Antibodies Services for HIST1H4J
    Abcam antibodies for HIST1H4J
    Cloud-Clone Corp. Antibodies for HIST1H4J 
    Search ThermoFisher Antibodies for HIST1H4J
    Search LSBio for Antibodies for HIST1H4J 

    Assay Products for HIST1H4J: 
    EMD Millipore Kits and Assays for the Analysis of HIST1H4J
    OriGene Custom Assay Services for HIST1H4J
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H4J
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H4J 
    Cloud-Clone Corp. CLIAs for HIST1H4J


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST1H4J for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H4J for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H4J 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H4J

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H4J 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H4J 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4J
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HIST1H4J
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIST1H4J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4J

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST1H4J
    Sirion Biotech Customized adenovirus for overexpression of HIST1H4J

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HIST1H4J (see all 8)
    OriGene ORF clones in mouse, rat for HIST1H4J
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H4J (NM_021968)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4J
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4J
    Sirion Biotech Customized lentivirus for stable overexpression of HIST1H4J 
                         Customized lentivirus expression plasmids for stable overexpression of HIST1H4J 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST1H4J
    Search LifeMap BioReagents cell lines for HIST1H4J
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4J


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H4J About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    3Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    4Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    5Assembly of RNA Polymerase-II Initiation Complex
    Crosstalk Between CARM1 and ESRs0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for HIST1H4J
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H4J
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4J
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST1H4J
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    5/11        Reactome Pathways for HIST1H4J (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H4J):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H4J for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H4J

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/637 Interacting proteins for HIST1H4J (P628051, 2, 3 ENSP000003471684) via UniProtKB, MINT, STRING, and/or I2D (see all 637)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3EP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST1H4J for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST1H4J:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H4J (H4)

    Search CenterWatch for drugs/clinical trials and news about HIST1H4J / H4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H4J gene: 
    NM_021968.3  

    Unigene Cluster for HIST1H4J:

    Histone cluster 1, H4j
    Hs.278483  [show with all ESTs]
    Unigene Representative Sequence: BE973853
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000355057(uc003njp.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4J
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HIST1H4J
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIST1H4J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4J
    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H4J (see all 8)
    OriGene ORF clones in mouse, rat for HIST1H4J
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H4J (NM_021968)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4J
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4J
    Sirion Biotech Customized lentivirus for stable overexpression of HIST1H4J 
                         Customized lentivirus expression plasmids for stable overexpression of HIST1H4J 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HIST1H4J
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H4J
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HIST1H4J
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4J
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4J

    Additional mRNA sequence: 

    AF086564.1 BC017361.2 BC062345.1 BC120940.2 BC148271.1 

    3 DOTS entries:

    DT.208774  DT.101973526  DT.99935921 

    16 AceView cDNA sequences:

    NM_021968 BC017361 BC062345 BU849117 AW451698 AF086564 BU533398 AI653010 
    NM_003541 BE669804 AA702915 CD175217 AI420192 CD175201 AA010078 BE973853 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H4J expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTGGTCT
    HIST1H4J Expression
    About this image


    See HIST1H4J Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H4J

    SOURCE GeneReport for Unigene cluster: Hs.278483
        SABiosciences Custom PCR Arrays for HIST1H4J
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HIST1H4J
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H4J
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HIST1H4J
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4J
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4J
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4J

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIST1H4J gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h4j5 histone cluster 1, H4j   --   13 (7.94 cM) 21735064 
    chicken
    (Gallus gallus)
    Aves LOC1008583191 histone H4-like 89(n)
    100(a)
      100858319  XM_003640370.1  XP_003640418.1 
    lizard
    (Anolis carolinensis)
    Reptilia HIST1H4I6
    HIST1H4I6
    Histone H4
    100(a)
    100(a)
    possible ortholog
    possible ortholog
    GL343279.1(544925-545236)
    GL343466.1(310644-310955)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1534091 zgc:153409 79.94(n)
    99.03(a)
      767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338771 CG33877-PA 77.99(n)
    98.06(a)
      3772211  NM_001032191.1  NP_001027362.1 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AER012C1 AER012Cp 82.52(n)
    90.29(a)
      4621072  NM_210226.1  NP_984872.1 


    ENSEMBL Gene Tree for HIST1H4J (if available)
    TreeFam Gene Tree for HIST1H4J (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H4J gene
    HIST1H4K1 2  HIST1H4I1 2  HIST1H4A1 2  HIST1H4L1 2  HIST2H4A1 2  HIST1H4E1 2  HIST2H4B1 2  HIST1H4B1 2  
    HIST1H4F1 2  HIST1H4D1 2  HIST1H4H1 2  HIST4H41 2  HIST1H4C1 2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4J using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4L    HIST1H4H    HIST1H4G

    HIST1H4J for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 SNPs in HIST1H4J are shown (see all 105)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847467931,2
    --27790152(+) TGTGGC/TCAGTT 1 -- us2k10--------
    rs1878984831,2
    --27790164(+) TTACAC/TGAAAA 1 -- us2k10--------
    rs2017885551,2
    --27790197(+) TGTTT-/TTTTC 
            
    TTTTC
    1 -- us2k10--------
    rs1921394551,2
    --27790222(+) CTTTTC/TTTTTG 1 -- us2k10--------
    rs1853240361,2
    --27790541(+) TTTATA/TACTTA 1 -- us2k10--------
    rs1897832561,2
    --27790720(+) TTGAGC/GAAAAT 1 -- us2k10--------
    rs1435282311,2
    --27790830(+) TTTAAA/GTTAGG 1 -- us2k10--------
    rs728473431,2
    C,F--27790833(+) AAATTA/GGGAAA 1 -- us2k11Minor allele frequency- G:0.07NA 120
    rs1813888591,2
    --27791038(+) TTTTGC/GTAATA 1 -- us2k10--------
    rs94614141,2
    C,F,H--27791063(+) TAATGT/CTAAAG 1 -- us2k15Minor allele frequency- C:0.00NS EA 598

    HapMap Linkage Disequilibrium report for HIST1H4J (27791884 - 27792258 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H4J:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883512CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H4J
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4J

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602826    OMIM disorders: --

    6 diseases for HIST1H4J:    About MalaCards
    non-hodgkin lymphoma    hodgkin's lymphoma    systemic lupus erythematosus    lupus erythematosus
    hepatocellular carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIST1H4J:
    Cancer

    HIST1H4J for disorders           About GeneDecksing


    Export disorders for HIST1H4J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H4J gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with HIST1H4J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. The structure of the human histone genes: clustered but not tandemly repeated. (PubMed id 6265100)1, 3 Heintz N....Roeder R.G. (1981)
    4. A conserved function for the H2A.Z C terminus. (PubMed id 22493515)1 Wratting D....Millar C.B. (2012)
    5. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    8. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    9. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
    10. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8363 HGNC: 4785 AceView: HIST1H4J Ensembl:ENSG00000197238 euGenes: HUgn8363
    ECgene: HIST1H4J Kegg: 8363 H-InvDB: HIST1H4J

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H4J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H4J gene:
    Search GeneIP for patents involving HIST1H4J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for HIST1H4J
     EMD Millipore Kits and Assays for the Analysis of HIST1H4J
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4J
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Purified and/or Recombinant HIST1H4J Protein
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HIST1H4J  
     OriGene qPCR primer pairs and template standards for HIST1H4J   OriGene Protein Over-expression Lysate for HIST1H4J  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HIST1H4J  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H4J   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HIST1H4J   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H4J   OriGene Custom Protein Services for HIST1H4J  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST1H4J
     QIAGEN SeqTarget long-range PCR primers for resequencing HIST1H4J
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4J
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4J
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4J
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4J
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H4J GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H4J
     GenScript Custom Assay Services for HIST1H4J GenScript Custom Superior Antibodies Services for HIST1H4J
     GenScript Custom overexpressing Cell Line Services for HIST1H4J CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HIST1H4J promoter
     Search Chromatin IP Primers for HIST1H4J
     Search RT2 qPCR Primer Assays in human, mouse, rat HIST1H4J
     Search GNC Networks for HIST1H4J
     SABiosciences PCR Arrays including humanmouse / rat HIST1H4J
     Search Tocris compounds for HIST1H4J (H4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HIST1H4J proteins
     HIST1H4J lysates
     Antibodies for HIST1H4J
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H4J
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HIST1H4J
     Antibodies for HIST1H4J
     ELISAs for HIST1H4J
     CLIAs for HIST1H4J
     Search LifeMap BioReagents cell lines for HIST1H4J
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4J
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H4J
     SwitchGear Promoter luciferase reporter plasmids for HIST1H4J
     Search ThermoFisher Antibodies for HIST1H4J
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4J
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H4J
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H4J
    Customized:
     lentivirus for stable overexpression of HIST1H4J
     lentivirus expression plasmids for stable overexpression of HIST1H4J
     adenovirus for overexpression of HIST1H4J
     Search LSBio for Antibodies for HIST1H4J
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST1H4J gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4