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Aliases for HIST1H4J Gene

Aliases for HIST1H4J Gene

  • Histone Cluster 1 H4 Family Member J 2 3 5
  • H4 Histone Family, Member E 2 3
  • Histone Cluster 1, H4j 2 3
  • Histone 1, H4j 2 3
  • H4/E 3 4
  • H4FE 3 4
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • Histone H4 3
  • DJ160A22.2 3
  • HIST2H4 4
  • H4F2iv 3
  • H4FA 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4J Gene

Previous HGNC Symbols for HIST1H4J Gene

  • H4FE

Previous GeneCards Identifiers for HIST1H4J Gene

  • GC06P027850
  • GC06P027899
  • GC06P027791
  • GC06P027603

Summaries for HIST1H4J Gene

Entrez Gene Summary for HIST1H4J Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4J Gene

HIST1H4J (Histone Cluster 1 H4 Family Member J) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and DNA Double Strand Break Response. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot for HIST1H4J Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Additional gene information for HIST1H4J Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4J Gene

Genomics for HIST1H4J Gene

Regulatory Elements for HIST1H4J Gene

Enhancers for HIST1H4J Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H027834 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +13.2 13185 6 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 RCOR2 NBN ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN12 ZSCAN9 HNRNPA1P1 HIST1H2BPS2 OR2B2 CD83P1 LOC442172
GH06H027805 2 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -12.0 -11994 12 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZKSCAN8 ZNF603P ZSCAN12 ZKSCAN3 ZSCAN9 ZKSCAN4 ZSCAN26 ZNF192P1 HIST1H4K ZNF204P
GH06H027887 1.8 FANTOM5 ENCODE dbSUPER 3 +69.4 69373 11 ZFP64 DMAP1 YY1 ZNF143 NFYC SSRP1 ZNF610 RCOR2 NBN NR2C1 ZKSCAN4 ZKSCAN8 ZKSCAN3 ZSCAN9 ZNF603P ZSCAN12 ZSCAN26 HIST1H4K HIST1H3H HIST1H2BN
GH06H027819 1 Ensembl ENCODE 0.7 -4.3 -4286 1 CTCF ZMYM3 RAD21 RELA ZNF316 SMC3 ZNF143 MIXL1 SMARCA5 ZNF654 ZNF603P HIST1H2BM HIST1H4J
GH06H027821 1 ENCODE 0.7 -0.2 -203 4 HDGF HNRNPUL1 ATF1 FOXA2 ARNT ARID4B SIN3A YY1 ELK1 ZNF207 ZKSCAN4 ZSCAN9 ZKSCAN8 ZSCAN12 ZKSCAN3 HIST1H3J HIST1H1B HIST1H2BO HIST1H3I HIST1H4L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H4J on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H4J Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195178 492 2401 HNRNPUL1 ATF1 FOXA2 ARNT ARID4B SIN3A YY1 ELK1 ZNF207 ATF7

Genomic Location for HIST1H4J Gene

Chromosome:
6
Start:
27,824,108 bp from pter
End:
27,824,480 bp from pter
Size:
373 bases
Orientation:
Plus strand

Genomic View for HIST1H4J Gene

Genes around HIST1H4J on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4J Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4J Gene

Proteins for HIST1H4J Gene

  • Protein details for HIST1H4J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4J Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4J Gene

neXtProt entry for HIST1H4J Gene

Post-translational modifications for HIST1H4J Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H4J Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4J Gene

Domains & Families for HIST1H4J Gene

Gene Families for HIST1H4J Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST1H4J Gene

Suggested Antigen Peptide Sequences for HIST1H4J Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4J: view

Function for HIST1H4J Gene

Molecular function for HIST1H4J Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H4J Gene

Gene Ontology (GO) - Molecular Function for HIST1H4J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,TAS 3035717
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IBA,IPI 20498094
genes like me logo Genes that share ontologies with HIST1H4J: view

Phenotypes for HIST1H4J Gene

genes like me logo Genes that share phenotypes with HIST1H4J: view

Animal Model Products

CRISPR Products

miRNA for HIST1H4J Gene

miRTarBase miRNAs that target HIST1H4J

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HIST1H4J
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4J Gene

Localization for HIST1H4J Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H4J gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H4J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IBA --
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST1H4J: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H4J Gene

Pathways & Interactions for HIST1H4J Gene

SuperPathways for HIST1H4J Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H4J: view

Interacting Proteins for HIST1H4J Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347168%0d%0a9606.ENSP00000296417%0d%0a9606.ENSP00000336868%0d%0a9606.ENSP00000303408%0d%0a9606.ENSP00000358151%0d%0a9606.ENSP00000342886%0d%0a
Selected Interacting proteins: P62805-H4_HUMAN ENSP00000347168 for HIST1H4J Gene via MINT UniProtKB STRING IID

Symbol External ID(s) Details
TP53BP1
KDM4A
BRD2
YWHAZ
SMARCA5

Gene Ontology (GO) - Biological Process for HIST1H4J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IBA,IDA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST1H4J: view

No data available for SIGNOR curated interactions for HIST1H4J Gene

Drugs & Compounds for HIST1H4J Gene

No Compound Related Data Available

Transcripts for HIST1H4J Gene

mRNA/cDNA for HIST1H4J Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4J Gene

Histone cluster 1, H4j:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HIST1H4J
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4J Gene

No ASD Table

Relevant External Links for HIST1H4J Gene

GeneLoc Exon Structure for
HIST1H4J
ECgene alternative splicing isoforms for
HIST1H4J

Expression for HIST1H4J Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H4J Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H4J Gene

This gene is overexpressed in Liver (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H4J Gene



Protein tissue co-expression partners for HIST1H4J Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HIST1H4J Gene:

HIST1H4J

SOURCE GeneReport for Unigene cluster for HIST1H4J Gene:

Hs.278483

Evidence on tissue expression from TISSUES for HIST1H4J Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Eye(4.2)
  • Blood(2.3)
  • Intestine(2.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with HIST1H4J: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4J Gene

Orthologs for HIST1H4J Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIST1H4J Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 100 (a)
ManyToMany
LOC617875 33
  • 86.73 (n)
mouse
(Mus musculus)
Mammalia Hist1h4j 34
  • 100 (a)
OneToOne
Hist1h4f 33 16
  • 89.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hist1h4b 33
  • 89.97 (n)
chicken
(Gallus gallus)
Aves H4-I 34
  • 100 (a)
OneToMany
HIST1H46 33
  • 88.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495184 33
  • 84.79 (n)
zebrafish
(Danio rerio)
Actinopterygii HIST1H4H 34
  • 100 (a)
OneToMany
si:ch211-113a14.13 33
  • 80.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33873 33
  • 78.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 36
Species where no ortholog for HIST1H4J was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H4J Gene

ENSEMBL:
Gene Tree for HIST1H4J (if available)
TreeFam:
Gene Tree for HIST1H4J (if available)

Paralogs for HIST1H4J Gene

(14) SIMAP similar genes for HIST1H4J Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HIST1H4J: view

Variants for HIST1H4J Gene

Sequence variations from dbSNP and Humsavar for HIST1H4J Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000167315 -- 27,822,517(+) GCGCC(C/G)CTTCC upstream-variant-2KB
rs1000198241 -- 27,822,856(+) TAACA(C/T)AGAAT upstream-variant-2KB
rs1000510851 -- 27,823,880(+) TTTTT(A/T)AAAGC upstream-variant-2KB
rs1002211115 -- 27,824,586(+) CAGCG(C/G)CACAC downstream-variant-500B
rs1005880844 -- 27,824,498(+) AAGAG(A/T)GGTAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4J Gene

Variant ID Type Subtype PubMed ID
esv3608440 CNV loss 21293372

Variation tolerance for HIST1H4J Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H4J Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H4J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4J Gene

Disorders for HIST1H4J Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

Relevant External Links for HIST1H4J

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H4J

No disorders were found for HIST1H4J Gene.

No data available for MalaCards and Genatlas for HIST1H4J Gene

Publications for HIST1H4J Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 60
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4 60
  3. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 3 4 60
  4. The structure of the human histone genes: clustered but not tandemly repeated. (PMID: 6265100) Heintz N … Roeder RG (Cell 1981) 2 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for HIST1H4J Gene

Sources for HIST1H4J Gene