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Aliases for HIST1H4I Gene

Aliases for HIST1H4I Gene

  • Histone Cluster 1, H4i 2 3
  • H4FM 3 4 6
  • H4 Histone Family, Member M 2 3
  • Histone 1, H4i 2 3
  • H4/M 3 4
  • H4M 3 6
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • Histone 4 Family, Member M 3
  • Histone Family Member 3
  • Histone H4 3
  • HIST2H4 4
  • H4/G 4
  • H4FG 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4I Gene

Previous Symbols for HIST1H4I Gene

  • H4FM

Summaries for HIST1H4I Gene

Entrez Gene Summary for HIST1H4I Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H4I Gene

HIST1H4I (Histone Cluster 1, H4i) is a Protein Coding gene. Among its related pathways are Disease and Apoptotic Pathways in Synovial Fibroblasts.

UniProtKB/Swiss-Prot for HIST1H4I Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H4I Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4I Gene

Genomics for HIST1H4I Gene

Genomic Location for HIST1H4I Gene

Start:
27,138,588 bp from pter
End:
27,139,881 bp from pter
Size:
1,294 bases
Orientation:
Plus strand

Genomic View for HIST1H4I Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H4I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4I Gene

Regulatory Elements for HIST1H4I Gene

Proteins for HIST1H4I Gene

  • Protein details for HIST1H4I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4I Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4I Gene

neXtProt entry for HIST1H4I Gene

Proteomics data for HIST1H4I Gene at MOPED

Post-translational modifications for HIST1H4I Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80

Other Protein References for HIST1H4I Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4I Gene

Domains for HIST1H4I Gene

Gene Families for HIST1H4I Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H4I Gene

UniProtKB/Swiss-Prot:

H4_HUMAN
Family:
  • Belongs to the histone H4 family.:
    • P62805
genes like me logo Genes that share domains with HIST1H4I: view

Function for HIST1H4I Gene

Molecular function for HIST1H4I Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H4I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 3035717
GO:0005515 protein binding IPI 10220385
GO:0035575 histone demethylase activity (H4-K20 specific) TAS --
GO:0042393 histone binding IPI 20498094
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST1H4I: view

miRNA for HIST1H4I Gene

miRTarBase miRNAs that target HIST1H4I

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H4I Gene

Localization for HIST1H4I Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4I Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H4I Gene COMPARTMENTS Subcellular localization image for HIST1H4I gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 4

Gene Ontology (GO) - Cellular Components for HIST1H4I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000786 nucleosome TAS 3035717
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 14585971
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST1H4I: view

Pathways for HIST1H4I Gene

genes like me logo Genes that share pathways with HIST1H4I: view

Gene Ontology (GO) - Biological Process for HIST1H4I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000723 telomere maintenance TAS --
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly TAS --
genes like me logo Genes that share ontologies with HIST1H4I: view

Transcripts for HIST1H4I Gene

mRNA/cDNA for HIST1H4I Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4I Gene

Histone cluster 1, H4i:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4I Gene

No ASD Table

Relevant External Links for HIST1H4I Gene

GeneLoc Exon Structure for
HIST1H4I
ECgene alternative splicing isoforms for
HIST1H4I

Expression for HIST1H4I Gene

mRNA expression in normal human tissues for HIST1H4I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H4I Gene

This gene is overexpressed in Whole Blood (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HIST1H4I Gene

SOURCE GeneReport for Unigene cluster for HIST1H4I Gene Hs.248172

genes like me logo Genes that share expressions with HIST1H4I: view

Orthologs for HIST1H4I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748545 36
  • 80.91 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia LOC527645 36
  • 88.03 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist1h4h 36
  • 89 (n)
  • 100 (a)
Hist1h4i 16
rat
(Rattus norvegicus)
Mammalia Hist1h4a 36
  • 88.67 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves HIST1H46L4 36
  • 87.06 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731642 36
  • 83.82 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794549 36
  • 83.82 (n)
  • 100 (a)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33885 36
  • 79.29 (n)
  • 99.03 (a)
worm
(Caenorhabditis elegans)
Secernentea his-14 36
  • 77.67 (n)
  • 99.03 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HIS4 36
  • 72.49 (n)
  • 98.06 (a)
rice
(Oryza sativa)
Liliopsida Os09g0553100 36
  • 83.5 (n)
  • 98.06 (a)
Species with no ortholog for HIST1H4I:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H4I Gene

ENSEMBL:
Gene Tree for HIST1H4I (if available)
TreeFam:
Gene Tree for HIST1H4I (if available)

Paralogs for HIST1H4I Gene

Selected SIMAP similar genes for HIST1H4I Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H4I: view

No data available for Paralogs for HIST1H4I Gene

Variants for HIST1H4I Gene

Sequence variations from dbSNP and Humsavar for HIST1H4I Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs77329513 -- 27,137,727(+) TTAAC(A/G)TATTC upstream-variant-2KB
rs142314881 -- 27,137,572(+) CTGAG(C/T)TATAA upstream-variant-2KB
rs181561633 -- 27,137,564(+) AAAAT(A/G)TTCTG upstream-variant-2KB
rs191213858 -- 27,137,484(+) TTCTC(A/G)CTGGA upstream-variant-2KB
rs373542045 -- 27,137,369(+) CAGGA(A/G)ACCTT upstream-variant-2KB

Relevant External Links for HIST1H4I Gene

HapMap Linkage Disequilibrium report
HIST1H4I
Human Gene Mutation Database (HGMD)
HIST1H4I

No data available for Structural Variations from Database of Genomic Variants (DGV) for HIST1H4I Gene

Disorders for HIST1H4I Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

(1) University of Copenhagen DISEASES for HIST1H4I Gene

genes like me logo Genes that share disorders with HIST1H4I: view

Publications for HIST1H4I Gene

  1. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4
  2. A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene. (PMID: 8988030) Akasaka T. … Okuma M. (Cancer Res. 1997) 2 3 4
  3. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  4. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W. … Doenecke D. (Gene 1997) 3 4
  5. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 3 4

Products for HIST1H4I Gene

Sources for HIST1H4I Gene

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