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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H4H Gene

protein-coding   GIFtS: 53
GCID: GC06M026281

histone cluster 1, H4h

(Previous names: H4 histone family, member H, histone 1, H4h )
(Previous symbol: H4FH)
 Explore 7 diseases affiliated with
HIST1H4H via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H4H    

Aliases
for HIST1H4H gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H4h1 2     H4/N3
H4FH1 2 3 5     H4/O3
H4/H3     H4F23
H4 Histone Family, Member H1 2     H4FA3
Histone 1, H4h1 2     H4FB3
Histone H42     H4FC3
H4/A3     H4FD3
H4/B3     H4FE3
H4/C3     H4FG3
H4/D3     H4FI3
H4/E3     H4FJ3
H4/G3     H4FK3
H4/H3     H4FM3
H4/I3     H4FN3
H4/J3     H4FO3
H4/K3     HIST2H43
H4/M3     

External Ids:    HGNC: 47881   Entrez Gene: 83652   Ensembl: ENSG000001584067   OMIM: 6028285   UniProtKB: P628053   

Export aliases for HIST1H4H gene to outside databases

Previous GC identifers: GC06M026339 GC06M026389 GC06M026228


Summaries
for HIST1H4H gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H4H:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H4H


Genomic Views
for HIST1H4H gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H4H gene promoter:
         SRF   SRF (504 AA)   HSF1 (long)   Nkx2-5   Arnt   GATA-1   Max   HSF1short   SEF-1 (1)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H4H promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H4H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4H gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026281:  view genomic region     (about GC identifiers)

Start:
 26,281,283 bp from pter      End:
 26,285,762 bp from pter
Size:
 4,480 bases      Orientation:
 minus strand

Proteins
for HIST1H4H gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST1H4H (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4H: NX_P62805

Post-translational modifications:

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the
    • genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation
    • at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4
    (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by
    • SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone
    • chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    • between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone
    H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may
    function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21
    methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62805

    • HIST1H4H Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003534.1  
    ENSEMBL proteins: 
     ENSP00000366956   ENSP00000289352  
    Reactome Protein details: P62805
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant HIST1H4H Protein
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HIST1H4H
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    Novus Biologicals HIST1H4H Protein
    Novus Biologicals HIST1H4H Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H4H

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----


    HIST1H4H for ontologies           About GeneDecksing



    HIST1H4H Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4H
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    Abcam antibodies for HIST1H4H 
    Uscn Antibodies for HIST1H4H
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    Assay Products for HIST1H4H: 
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    Uscn ELISAs and CLIAs for HIST1H4H

    Protein Domains /
    Families
    for HIST1H4H gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H4H for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    Function
    for HIST1H4H gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4H
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    hsa-miR-9 hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H4H (see all 4)
    OriGene shRNA RFP: HIST1H4H
    OriGene siRNA: HIST1H4H
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4H

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4H 

    Cell Line
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    Search LifeMap BioReagents cell lines for HIST1H4H

    In Situ Assay
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         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4H

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----


    HIST1H4H for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST1H4H gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    2Transcription_Sin3 and NuRD in transcription regulation
    		Transcription_Sin3 and NuRD in transcription regulation1.00
    		Transcription Sin3 and NuRD in transcription regulation0.96
    3Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    4Development NOTCH1-mediated pathway for NF-KB activity modulation
    		Development NOTCH1-mediated pathway for NF-KB activity modulation1.00
    		Development_NOTCH1-mediated pathway for NF-KB activity modulation0.88
    5Type II interferon signaling (IFNG)
    		Type II interferon signaling (IFNG)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for HIST1H4H
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H4H
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4H
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    2 BioSystems Pathways for HIST1H4H 
        Type II interferon signaling (IFNG)
    Signaling events mediated by HDAC Class III

    5/17        Reactome Pathways for HIST1H4H (see all 17)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Disease


    1         Kegg Pathway  (Kegg details for HIST1H4H):
        Systemic lupus erythematosus


    HIST1H4H for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H4H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/604 Interacting proteins for HIST1H4H (P628051, 2, 3 ENSP000002893524) via UniProtKB, MINT, STRING, and/or I2D (see all 604)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3EP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----
    GO:0045653negative regulation of megakaryocyte differentiation ----


    HIST1H4H for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H4H gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST1H4H:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H4H
    Search CenterWatch for drugs/clinical trials and news about HIST1H4H / H4 

    Transcripts
    for HIST1H4H gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H4H gene: 
    NM_003543.3  

    Unigene Cluster for HIST1H4H:

    Histone cluster 1, H4h
    Hs.591790  [show with all ESTs]
    Unigene Representative Sequence: CD050439
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377727(uc003nhm.2) ENST00000289352(uc003nhl.1)

    miRNA
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    hsa-miR-9 hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4H
    Clone
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    Primer
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    Additional cDNA sequence: 

    BC120939.2 CR542169.1 CR542187.1 

    3 DOTS entries:

    DT.405495  DT.101970378  DT.91717593 

    24/59 AceView cDNA sequences (see all 59):

    BC010926 AI184259 NM_003543 AI089974 BX117028 BQ302851 BF513750 BX644367 
    AI539413 BQ302854 AI682486 CF129654 AI637510 CR542169 CD368728 AI141770 
    BF911505 BG221558 AA702781 CB048803 AW025566 BG678200 CR542187 AI939319 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4H    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -     -               
    SP2:                                                
    SP3:                          -     -               


    ECgene alternative splicing isoforms for HIST1H4H

    Expression
    for HIST1H4H gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H4H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HIST1H4H Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H4H

    SOURCE GeneReport for Unigene cluster: Hs.591790
        SABiosciences Custom PCR Arrays for HIST1H4H
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4H

    Orthologs
    for HIST1H4H gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIST1H4H gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H41 germinal histone H4 gene 81.23(n)
    100(a)    		   417946  NM_001037845.1  NP_001032934.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 100(a)
    		 1 ↔ 1
    		 GL343279.1(544925-545236)
    African clawed frog
    (Xenopus laevis)    		 Amphibia h4-A2 histone H4 protein 80.37(n)    AJ556873.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1534091 zgc:153409 78.64(n)
    99.03(a)    		   767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta His4:CG338771 CG33877-PA 79.94(n)
    98.06(a)    		   3772211  NM_001032191.1  NP_001027362.1 
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_AER012C1 AER012Cp 76.7(n)
    90.29(a)    		   4621072  NM_210226.1  NP_984872.1 


    ENSEMBL Gene Tree for HIST1H4H (if available)
    TreeFam Gene Tree for HIST1H4H (if available) 

    Paralogs
    for HIST1H4H gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H4H gene
    HIST1H4E1 2  HIST1H4A1 2  HIST1H4D1 2  HIST1H4F1 2  HIST1H4K1 2  HIST1H4B1 2  HIST1H4J1 2  HIST1H4I1 2  
    HIST2H4A1 2  HIST2H4B1 2  HIST1H4C1 2  HIST4H41 2  HIST1H4L1 2  HIST1H4G2  
    14 SIMAP similar genes for HIST1H4H using alignment to 2 protein entries:     H4_HUMAN (see all proteins):
    HIST1H4J    HIST1H4A    HIST1H4B    HIST1H4C    HIST1H4D    HIST1H4E
    HIST1H4F    HIST1H4I    HIST1H4K    HIST1H4L    HIST2H4A    HIST2H4B
    HIST4H4    HIST1H4G

    HIST1H4H for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HIST1H4H
    PGOHUM00000232993 PGOHUM00000263308


    Genomic Variants
    for HIST1H4H gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/36 NCBI SNPs in HIST1H4H are shown (see all 36)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1439232881,2
    		C,--26285428(+) CCGAAG/ACCGTA 2 /G syn11Minor allele frequency- A:0.00NA 4548
    rs773579821,2
    		C,F,--26285485(+) GTCACG/AGTCTT 2 /T syn11Minor allele frequency- A:0.02EA 120
    rs1472820321,2
    		--26285491(+) GTCTTA/GCGTTT 2 R syn10--------
    rs115488891,2
    		H--26285492(-) CAAACG/ACAAGA 2 /H /R mis1 ese34Minor allele frequency- A:0.00NS EA 402
    rs1407952601,2
    		C,--26285497(+) CGTTTA/GGCGTG 2 A syn10--------
    rs412668291,2
    		C,F,--26285503(+) GCGTGC/TTCTGT 2 E syn110Minor allele frequency- T:0.14NA NS WA CSA EA EU 6313
    rs1415114201,2
    		F--26285518(+) GTGACA/GGCGTC 2 A syn11Minor allele frequency- G:0.00NA 4552
    rs1452722231,2
    		C,F--26285542(+) TCCAGG/AAACAC 2 /F syn12Minor allele frequency- A:0.00NA EU 5873
    rs2020668501,2
    		C,--26285545(+) AGGAAC/TACCTT 2 V syn11Minor allele frequency- T:0.00EU 1323
    rs23935921,2
    		C,F,A,H,--26285560(+) ACACCG/ACGAGT 2 /R syn1 ese333Minor allele frequency- A:0.46NS EA NA WA CSA EU 9009

    HapMap Linkage Disequilibrium report for HIST1H4H (26281283 - 26285762 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H4H: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for HIST1H4H gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H4H for disorders           About GeneDecksing

    OMIM gene information: 602828    OMIM disorders: --

    7 diseases for HIST1H4H:    About MalaCards
    non-hodgkin lymphoma    systemic lupus erythematosus    lupus erythematosus    hodgkin's lymphoma
    hepatocellular carcinoma    immunodeficiency    carcinoma

    1 disease from the University of Copenhagen DISEASES database for HIST1H4H:
    Cancer

    Export disorders for HIST1H4H gene to outside databases

    Publications
    for HIST1H4H gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H4H gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with HIST1H4H)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    4. A conserved function for the H2A.Z C terminus. (PubMed id 22493515)1 Wratting D....Millar C.B. (2012)
    5. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    8. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
    9. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    10. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)2 Kang B....Zhang Z. (2011)

    External Searches for HIST1H4H gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H4H gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8365 HGNC: 4788 AceView: HIST1H4H Ensembl:ENSG00000158406 euGenes: HUgn8365
    ECgene: HIST1H4H Kegg: 8365 H-InvDB: HIST1H4H

    Other Databases showing HIST1H4H gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H4H gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H4H Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H4H gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H4H gene:
    Search GeneIP for patents involving HIST1H4H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics
    About This Section

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