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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H4G Gene

protein-coding   GIFtS: 48
GCID: GC06M026300

histone cluster 1, H4g

(Previous names: H4 histone family, member L, histone 1, H4g )
(Previous symbol: H4FL)
 Explore 4 diseases affiliated with
HIST1H4G via our new
 Human Malady Compendium 
Biological research products
for HIST1H4G
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Histone Cluster 1, H4g1 2     Histone 1, H4g1 2
H4FL1 2 3 5     Histone H4-Like Protein Type G2
H4/L3     H4/L3
H4 Histone Family, Member L1 2     

External Ids:    HGNC: 47921   Entrez Gene: 83692   Ensembl: ENSG000001245787   OMIM: 6028325   UniProtKB: Q995253   

Export aliases for HIST1H4G gene to outside databases

Previous GC identifers: GC06M026305 GC06M026354 GC06M026248 GC06M026189 GC06M026249 GC06M026263


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H4G:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H4G_HUMAN, Q99525
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity)

Gene Wiki entry for HIST1H4G


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H4G gene promoter:
         AhR   SRF   GR   SRF (504 AA)   GR-beta   GATA-1   Arnt   ARP-1   GR-alpha   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIST1H4G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4G gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026300:  view genomic region     (about GC identifiers)

Start:
26,246,839 bp from pter      End:
26,247,259 bp from pter
Size:
421 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H4G_HUMAN, Q99525 (See protein sequence)
Recommended Name: Histone H4-like protein type G  
Size: 98 amino acids; 11009 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity)
Subcellular location: Nucleus (By similarity). Chromosome (By similarity)

Explore the universe of human proteins at neXtProt for HIST1H4G: NX_Q99525

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99525

  • HIST1H4G Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003538.1  
    ENSEMBL proteins: 
     ENSP00000244537  

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    Uscn Proteins for HIST1H4G

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--


    HIST1H4G for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIST1H4G for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry Q99525

    ProtoNet protein and cluster: Q99525

    1 Blocks protein family: IPB001951 Histone H4

    UniProtKB/Swiss-Prot: H4G_HUMAN, Q99525
    Similarity: Belongs to the histone H4 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: H4G_HUMAN, Q99525
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    HIST1H4G for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HIST1H4G:
     Decreased POU5F1-GFP protein e  Synthetic lethal with c-Myc af 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation1.00
    Histone modification0.31
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation1.00
    3Systemic lupus erythematosus
    Systemic lupus erythematosus1.00
    4Development_Notch Signaling Pathway
    Development Notch Signaling Pathway0.97
    5Transcription_Sin3 and NuRD in transcription regulation
    Transcription Sin3 and NuRD in transcription regulation0.96

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for HIST1H4G
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H4G
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs


    1         Kegg Pathway  (Kegg details for HIST1H4G):
        Systemic lupus erythematosus


    HIST1H4G for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H4G

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HIST1H4G (ENSP000002445374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFZENSP000002964174STRING: ENSP00000296417
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--


    HIST1H4G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H4G
    Search CenterWatch for drugs/clinical trials and news about HIST1H4G / H4G 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H4G gene: 
    NM_003547.2  

    Unigene Cluster for HIST1H4G:

    Histone cluster 1, H4g
    Hs.553507
    Unigene Representative Sequence: BC126276
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244537(uc003nhf.3)

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4G

    Additional cDNA sequence: 

    BC126276.1 BC126278.1 

    1 DOTS entry:

    DT.91929359 

    1 AceView cDNA sequence:

    NM_003547 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H4G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCGTGGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HIST1H4G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H4G

    SOURCE GeneReport for Unigene cluster: Hs.553507
        SABiosciences Custom PCR Arrays for HIST1H4G
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H4G gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves H4_CHICK6
    H4_CHICK6
    Histone H4
    77(a)
    75(a)
    possible ortholog
    possible ortholog
    1(49997877-49998203)
    1(50016239-50016574)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01041214.16
    --
    81(a)
    1 ↔ 1
    16(4633519-4633827)
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG339076
    His4:CG338996
    (see all 23)
    His4:CG33899
    (see all 23)
    80(a)
    80(a)
    (see all 23)
    possible ortholog
    possible ortholog
    (see all 23)
    2L(21429700-21430229)
    2L(21458898-21459421)
    worm
    (Caenorhabditis elegans)
    Secernentea his-266
    his-506
    (see all 16)
    Histone H4
    (see all 16)
    80(a)
    80(a)
    (see all 16)
    possible ortholog
    possible ortholog
    (see all 16)
    II(13825463-13825774)
    V(8847371-8847682)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G537306
    AT3G463206
    (see all 8)
    histone H4
    (see all 8)
    79(a)
    79(a)
    (see all 8)
    possible ortholog
    possible ortholog
    (see all 8)
    3(19912494-19913033)
    3(17019911-17020428)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 11)
    Core histone H2A/H2B/H3/H4 domain containing prote...
    Core histone H2A/H2B/H3/H4 domain containing prote...
    (see all 11)
    79(a)
    79(a)
    (see all 11)
    possible ortholog
    possible ortholog
    (see all 11)
    3(1079709-1080440)
    7(21826220-21826874)


    ENSEMBL Gene Tree for HIST1H4G (if available)
    TreeFam Gene Tree for HIST1H4G (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H4G gene
    HIST1H4E2  HIST1H4K2  HIST2H4A2  HIST4H42  HIST1H4F2  HIST2H4B2  HIST1H4L2  HIST1H4I2  
    HIST1H4B2  HIST1H4A2  HIST1H4H2  HIST1H4J2  HIST1H4D2  HIST1H4C2  
    14 SIMAP similar genes for HIST1H4G using alignment to 1 protein entry:     H4G_HUMAN:
    HIST1H4A    HIST1H4B    HIST1H4C    HIST1H4D    HIST1H4E    HIST1H4F
    HIST1H4I    HIST1H4J    HIST1H4K    HIST1H4L    HIST2H4A    HIST2H4B
    HIST4H4    HIST1H4H

    HIST1H4G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/72 NCBI SNPs in HIST1H4G are shown (see all 72    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414542211,2
    --26246462(+) GTATTA/CTCTGG 1 -- ds50010--------
    rs562032531,2
    C,F,--26246597(+) GAGAGC/ATTTTA 1 -- ds50014Minor allele frequency- A:0.17WA CSA 124
    rs1863414551,2
    --26246602(+) CTTTTA/TAGTGA 1 -- ds50010--------
    rs595004801,2
    --26246617(+) GTAGCC/TGTTGA 1 -- ds50010--------
    rs1815406231,2
    --26246622(+) CGTTGA/GTGTCC 1 -- ds50010--------
    rs1470028781,2
    --26246655(+) AATCTC/GTGAAC 1 -- ds50010--------
    rs69138281,2
    C,F,A,H,--26246664(+) ACACAC/TGATTA 1 -- ds500118Minor allele frequency- T:0.13NS EA NA CSA WA 2401
    rs1380366781,2
    --26246693(+) ATGTTC/GTATGT 1 -- ds50010--------
    rs796140891,2
    C,--26246708(+) CTTGGC/TGTAAA 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs94676931,2
    C,F,H,--26246784(+) TTGCTG/CAGTGC 1 -- ds50017Minor allele frequency- C:0.05NS EA WA 910

    HapMap Linkage Disequilibrium report for HIST1H4G (26246839 - 26247259 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H4G: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H4G
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HIST1H4G for disorders           About GeneDecksing

    OMIM gene information: 602832    OMIM disorders: --

    4 diseases for HIST1H4G:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    immunodeficiency    malaria


    Export disorders for HIST1H4G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H4G gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with HIST1H4G)
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    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. A conserved function for the H2A.Z C terminus. (PubMed id 22493515)1 Wratting D....Millar C.B. (2012)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    7. Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. (PubMed id 14657027)1 Lusic M....Giacca M. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. (PubMed id 11689053)1 Deng L....Kashanchi F. (2001)
    10. Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. (PubMed id 11080476)1 Deng L.... Kashanchi F. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8369 HGNC: 4792 AceView: HIST1H4G Ensembl:ENSG00000124578 euGenes: HUgn8369
    ECgene: HIST1H4G Kegg: 8369 H-InvDB: HIST1H4G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H4G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H4G gene:
    Search GeneIP for patents involving HIST1H4G

    GeneCards and IP:
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