Aliases for HIST1H4G Gene
Aliases for HIST1H4G Gene
External Ids for HIST1H4G Gene
- HGNC: 4792
- Entrez Gene: 8369
- Ensembl: ENSG00000275663
- OMIM: 602832
- UniProtKB: Q99525
Previous HGNC Symbols for HIST1H4G Gene
- H4FL
Previous GeneCards Identifiers for HIST1H4G Gene
- GC06M026305
- GC06M026354
- GC06M026248
- GC06M026189
- GC06M026249
- GC06M026263
- GC06M026300
- GC06M026409
- GC06M026438
- GC06M026421
- GC06M026463
- GC06M026484
- GC06M026503
- GC06M026530
Summaries for HIST1H4G Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H4G Gene
HIST1H4G (Histone Cluster 1 H4 Family Member G) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H4D.
UniProtKB/Swiss-Prot for HIST1H4G Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4G Gene
Genomics for HIST1H4G Gene
Regulatory Elements for HIST1H4G Gene
Enhancers for HIST1H4G Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H4G on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H4G gene promoter:
Regulatory Element Products
Genomic Location for HIST1H4G Gene
- Chromosome:
- 6
- Start:
- 26,246,611 bp from pter
- End:
- 26,246,977 bp from pter
- Size:
- 367 bases
- Orientation:
- Minus strand
Genomic View for HIST1H4G Gene
Genes around HIST1H4G on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H4G Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H4G Gene
Proteins for HIST1H4G Gene
-
Protein details for HIST1H4G Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99525-H4G_HUMAN
- Recommended name:
- Histone H4-like protein type G
- Protein Accession:
- Q99525
Protein attributes for HIST1H4G Gene
- Size:
- 98 amino acids
- Molecular mass:
- 11009 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
Protein Expression for HIST1H4G Gene
Post-translational modifications for HIST1H4G Gene
Other Protein References for HIST1H4G Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for HIST1H4G
Protein Products
-
OriGene Purified Proteins for HIST1H4G
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H4G
- Origene Custom Protein Services for HIST1H4G
- Novus Biologicals lysates for HIST1H4G
- Search GeneTex for Proteins for HIST1H4G
Assay Products
No data available for DME Specific Peptides for HIST1H4G Gene
Domains & Families for HIST1H4G Gene
Gene Families for HIST1H4G Gene
- HGNC:
Protein Domains for HIST1H4G Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H4G Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99525- Family:
-
- Belongs to the histone H4 family.
Function for HIST1H4G Gene
Molecular function for HIST1H4G Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0042393 | histone binding | IBA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H4G Gene
- GenomeRNAi human phenotypes for HIST1H4G:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4G gene
- Search ViGene Biosciences for HIST1H4G
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4G
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4G
miRNA for HIST1H4G Gene
- miRTarBase miRNAs that target HIST1H4G
miRNA Products
- Search ViGene Biosciences for HIST1H4G
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H4G
- Browse OriGene Inhibitory RNA Products For HIST1H4G
- Search ViGene Biosciences for HIST1H4G
Clone Products
-
OriGene ORF clones in human for HIST1H4G
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H4G
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H4G
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H4G gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4G gene
- Search ViGene Biosciences for HIST1H4G
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4G Gene
Localization for HIST1H4G Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4G Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000788 | nuclear nucleosome | IBA | -- |
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HIST1H4G Gene
Pathways by source for HIST1H4G Gene
1 BioSystems pathway for HIST1H4G Gene
3 KEGG pathways for HIST1H4G Gene
2 Qiagen pathways for HIST1H4G Gene
Interacting Proteins for HIST1H4G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IBA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for HIST1H4G Gene
Transcripts for HIST1H4G Gene
mRNA/cDNA for HIST1H4G Gene
- (1) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4G
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4G
miRNA Products
- Search ViGene Biosciences for HIST1H4G
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H4G
- Browse OriGene Inhibitory RNA Products For HIST1H4G
- Search ViGene Biosciences for HIST1H4G
Clone Products
-
OriGene ORF clones in human for HIST1H4G
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H4G
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H4G Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Plasma (39.7) and Pancreas (12.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H4G Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H4G Gene:
HIST1H4GSOURCE GeneReport for Unigene cluster for HIST1H4G Gene:
Hs.553507Primer Products
-
OriGene qPCR primer pairs for HIST1H4G
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4G Gene
Orthologs for HIST1H4G Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC472229 34 |
|
- Species where no ortholog for HIST1H4G was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIST1H4G Gene
Paralogs for HIST1H4G Gene
(14) SIMAP similar genes for HIST1H4G Gene using alignment to 1 proteins:
Variants for HIST1H4G Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002316739 | -- | 26,246,276(+) | AAGTC(A/G)GGTTA | downstream-variant-500B | |
| rs1003351870 | -- | 26,248,016(+) | TAGTA(C/G)AGACC | upstream-variant-2KB | |
| rs1003486567 | -- | 26,248,303(+) | AAAAA(A/G)GATAA | upstream-variant-2KB | |
| rs1004131048 | -- | 26,247,994(+) | CTCCC(A/G)GCTCA | upstream-variant-2KB | |
| rs1005159557 | -- | 26,246,301(+) | CTACA(A/G)TTTTA | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv601173 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.89;
59.19% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H4G Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H4G
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4G Gene
Disorders for HIST1H4G Gene
Relevant External Links for HIST1H4G
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H4G
No disorders were found for HIST1H4G Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H4G Gene
Publications for HIST1H4G Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3 64
- A conserved function for the H2A.Z C terminus. (PMID: 22493515) Wratting D. … Millar C.B. (J. Biol. Chem. 2012) 3 64
Products for HIST1H4G Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H4G Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (33) SOURCE
- (34) HomoloGene
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- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
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- (53) GenBank
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
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- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (100) COMPARTMENTS
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