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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H4F Gene

protein-coding   GIFtS: 54
GCID: GC06P026240

Histone Cluster 1, H4f

(Previous names: H4 histone family, member C, histone 1, H4f)
(Previous symbol: H4FC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H4f1 2     H4/M3
H4FC1 2 3 5     H4/N3
H4 Histone Family, Member C1 2     H4/O3
Histone 1, H4f1 2     H4F23
H42     H4FA3
H4/c2     H4FB3
Histone H42     H4FD3
H4/A3     H4FE3
H4/B3     H4FG3
H4/C3     H4FH3
H4/D3     H4FI3
H4/E3     H4FJ3
H4/G3     H4FK3
H4/H3     H4FM3
H4/I3     H4FN3
H4/J3     H4FO3
H4/K3     HIST2H43

External Ids:    HGNC: 47831   Entrez Gene: 83612   Ensembl: ENSG000001983277   OMIM: 6028245   UniProtKB: P628053   

Export aliases for HIST1H4F gene to outside databases

Previous GC identifers: GC06P026298 GC06P026348 GC06P026184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H4F Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4F Gene: 
HIST1H4F (histone cluster 1, H4f) is a protein-coding gene. Diseases associated with HIST1H4F include non-hodgkin lymphoma, and hodgkin's lymphoma, and among its related super-pathways are Signal transduction Activin A signaling regulation and Telomere Maintenance. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H4F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H4F gene promoter:
         SRF   GR   SRF (504 AA)   GR-beta   AREB6   E2F   E2F-1   ARP-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H4F promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H4F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4F gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026240:  view genomic region     (about GC identifiers)

Start:
26,240,561 bp from pter      End:
26,241,021 bp from pter
Size:
461 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST1H4F (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4F: NX_P62805

Explore proteomics data for HIST1H4F at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin
  • UniProtKB: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation
  • UniProtKB: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage
  • UniProtKB: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • UniProtKB: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H4
  • UniProtKB: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)
  • UniProtKB: Sumoylated, which is associated with transcriptional repression
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62805

  • HIST1H4F Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H4F Protein Expression
    REFSEQ proteins: NP_003531.1  
    ENSEMBL proteins: 
     ENSP00000366974  
    Reactome Protein details: P62805
    Human Recombinant Protein Products for HIST1H4F: 
    EMD Millipore Purified and/or Recombinant HIST1H4F Protein
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    Novus Biologicals HIST1H4F Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H4F 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST1H4F for ontologies           About GeneDecksing



    HIST1H4F Antibody Products: 
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    Abcam antibodies for HIST1H4F
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    Assay Products for HIST1H4F: 
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    Cloud-Clone Corp. ELISAs for HIST1H4F 
    Cloud-Clone Corp. CLIAs for HIST1H4F


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST1H4F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H4F for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H4F 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H4F

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H4F 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H4F 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4F
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H4F:
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4F


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H4F About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.56
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    Telomere Maintenance0.56
    Amyloids0.41
    Nucleosome assembly0.46
    3Meiotic Synapsis
    Meiotic Synapsis0.70
    Meiotic Recombination0.62
    Meiosis0.70
    Chromosome Maintenance0.56
    4Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    5Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for HIST1H4F
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H4F
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4F
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST1H4F
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    5/11        Reactome Pathways for HIST1H4F (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H4F):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H4F for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST1H4F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/639 Interacting proteins for HIST1H4F (P628051, 2, 3 ENSP000003669744) via UniProtKB, MINT, STRING, and/or I2D (see all 639)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3EP684312, 3, ENSP000003535814MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000353581
    HIST1H3AP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST1H4F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST1H4F:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H4F (H4)

    Search CenterWatch for drugs/clinical trials and news about HIST1H4F / H4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H4F gene: 
    NM_003540.3  

    Unigene Cluster for HIST1H4F:

    Histone cluster 1, H4f
    Hs.247816  [show with all ESTs]
    Unigene Representative Sequence: DA557005
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377745(uc003nhe.1)
    miRNA
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    Additional mRNA sequence: 

    BC069288.1 BC093763.1 BC093765.1 

    1 DOTS entry:

    DT.92033189 

    2 AceView cDNA sequences:

    NM_003540 BC069288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H4F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGTAGAG
    HIST1H4F Expression
    About this image


    See HIST1H4F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H4F

    SOURCE GeneReport for Unigene cluster: Hs.247816
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H4F gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h4f5 histone cluster 1, H4f   --   13 (9.78 cM) 23551258 
    chicken
    (Gallus gallus)
    Aves H41 germinal histone H4 gene 84.47(n)
    100(a)
      417946  NM_001037845.1  NP_001032934.1 
    lizard
    (Anolis carolinensis)
    Reptilia HIST1H4I6
    HIST1H4I6
    Histone H4
    100(a)
    100(a)
    1 ↔ 1
    possible ortholog
    GL343466.1(310644-310955)
    GL343279.1(544925-545236)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1534091 zgc:153409 76.05(n)
    99.03(a)
      767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338771 CG33877-PA 80.91(n)
    98.06(a)
      3772211  NM_001032191.1  NP_001027362.1 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AER012C1 AER012Cp 78.96(n)
    90.29(a)
      4621072  NM_210226.1  NP_984872.1 
    soybean
    (Glycine max)
    eudicotyledons CA851345.12   -- 78.73(n)    CA851345.1 


    ENSEMBL Gene Tree for HIST1H4F (if available)
    TreeFam Gene Tree for HIST1H4F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H4F gene
    HIST1H4I1 2  HIST1H4K1 2  HIST2H4A1 2  HIST2H4B1 2  HIST1H4J1 2  HIST1H4B1 2  HIST1H4L1 2  HIST1H4H1 2  
    HIST1H4A1 2  HIST1H4D1 2  HIST1H4E1 2  HIST1H4C1 2  HIST4H41 2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4F using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4L    HIST1H4H    HIST1H4G

    HIST1H4F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 SNPs in HIST1H4F are shown (see all 87)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916243811,2
    --26238782(+) TGCTCC/TGCCCT 1 -- us2k10--------
    rs1388356861,2
    --26239192(+) TAATGC/TTGAAT 1 -- us2k10--------
    rs774122071,2
    C,F--26239299(+) TGTTAA/GTTTAC 1 -- us2k11Minor allele frequency- G:0.04EA 120
    rs1428312421,2
    C--26239370(+) AGCAAC/GGTAGT 1 -- us2k10--------
    rs1826378451,2
    --26239371(+) GCAAGA/GTAGTG 1 -- us2k10--------
    rs93589131,2
    C,F,H--26239404(+) ATACAA/GTGCCA 1 -- us2k125Minor allele frequency- G:0.36EA NA NS WA 2966
    rs757319141,2
    C--26239432(+) TCTTCA/TAGCCT 1 -- us2k10--------
    rs168914741,2
    C,F--26239453(+) ATCTTT/GACACC 1 -- us2k18Minor allele frequency- G:0.13NA CSA WA EA 500
    rs1865699181,2
    --26239456(+) TTTACA/GCCTCA 1 -- us2k10--------
    rs757442981,2
    C,F--26239502(+) ACTTCA/GATTAA 1 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for HIST1H4F (26240561 - 26241021 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H4F:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428137CNV Loss18775914

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602824    OMIM disorders: --

    6 diseases for HIST1H4F:    About MalaCards
    non-hodgkin lymphoma    hodgkin's lymphoma    systemic lupus erythematosus    lupus erythematosus
    hepatocellular carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIST1H4F:
    Cancer

    HIST1H4F for disorders           About GeneDecksing


    Export disorders for HIST1H4F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H4F gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with HIST1H4F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W....Doenecke D. (1991)
    4. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)1, 2 Kang B....Zhang Z. (2011)
    5. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    6. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (1987)
    7. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    8. Structure of the variant histone H3.3-H4 heterodimer i n complex with its chaperone DAXX. (PubMed id 23142979)1 Liu C.P....Xu R.M. (2012)
    9. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    10. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8361 HGNC: 4783 AceView: HIST1H4F Ensembl:ENSG00000198327 euGenes: HUgn8361
    ECgene: HIST1H4F Kegg: 8361 H-InvDB: HIST1H4F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H4F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H4F gene:
    Search GeneIP for patents involving HIST1H4F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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