Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H4F Gene

protein-coding   GIFtS: 53
GCID: GC06P026240

histone cluster 1, H4f

(Previous names: H4 histone family, member C, histone 1, H4f )
(Previous symbol: H4FC)
 Explore 7 diseases affiliated with
HIST1H4F via our new
 Human Malady Compendium 
Biological research products
for HIST1H4F
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Histone Cluster 1, H4f1 2     H4/M3
H4FC1 2 3 5     H4/N3
H41 2     H4/O3
H4/C3     H4F23
H4 Histone Family, Member C1 2     H4FA3
Histone 1, H4f1 2     H4FB3
Histone H42     H4FD3
H4/A3     H4FE3
H4/B3     H4FG3
H4/C3     H4FH3
H4/D3     H4FI3
H4/E3     H4FJ3
H4/G3     H4FK3
H4/H3     H4FM3
H4/I3     H4FN3
H4/J3     H4FO3
H4/K3     HIST2H43

External Ids:    HGNC: 47831   Entrez Gene: 83612   Ensembl: ENSG000001983277   OMIM: 6028245   UniProtKB: P628053   

Export aliases for HIST1H4F gene to outside databases

Previous GC identifers: GC06P026298 GC06P026348 GC06P026184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H4F:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H4F


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H4F gene promoter:
         SRF   GR   SRF (504 AA)   GR-beta   AREB6   E2F   E2F-1   ARP-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H4F promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H4F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4F gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026240:  view genomic region     (about GC identifiers)

Start:
26,240,561 bp from pter      End:
26,241,021 bp from pter
Size:
461 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST1H4F (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4F: NX_P62805

Post-translational modifications:

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the
  • genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation
  • at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4
    (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by
  • SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone
  • chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
  • between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone
    H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may
    function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21
    methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
  • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62805

  • HIST1H4F Protein expression data from MOPED and PaxDb:    About this image 
    HIST1H4F Protein Expression
    REFSEQ proteins: NP_003531.1  
    ENSEMBL proteins: 
     ENSP00000366974  
    Reactome Protein details: P62805
    Human Recombinant Protein Products for HIST1H4F: 
    EMD Millipore Purified and/or Recombinant HIST1H4F Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HIST1H4F
    OriGene Custom Protein Services for HIST1H4F 
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H4F
    Novus Biologicals HIST1H4F Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H4F

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----

    HIST1H4F for ontologies           About GeneDecksing



    HIST1H4F Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4F
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST1H4F 
    GenScript Custom Superior Antibodies Services for HIST1H4F
    Abcam antibodies for HIST1H4F 
    Uscn Antibodies for HIST1H4F
    Search ThermoFisher Antibodies for HIST1H4F

    Assay Products for HIST1H4F: 
    EMD Millipore Kits and Assays for the Analysis of HIST1H4F
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H4F
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST1H4F


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIST1H4F for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
         
    HIST1H4F for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HIST1H4F 

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4F
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H4F:
    hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H4F (see all 4)
    OriGene shRNA RFP: HIST1H4F
    OriGene siRNA: HIST1H4F
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4F
    Sirion Biotech Custom design and validation of potent shRNA sequences against HIST1H4F 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST1H4F
    Sirion Biotech Customized adenovirus for overexpression of HIST1H4F 
    Sirion Biotech Customized adenovirus for potent knockdown of HIST1H4F

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4F (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIST1H4F (NM_003540)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4F 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST1H4F
    Search LifeMap BioReagents cell lines for HIST1H4F
    Sirion Biotech Customized stable knockdown cell line services for HIST1H4F 
    Sirion Biotech Customized inducible knockdown cell line services for HIST1H4F
    Sirion Biotech Customized stable overexpressing cell line services for HIST1H4F
    Sirion Biotech Customized inducible overexpressing cell line services for HIST1H4F

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4F


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    Meiotic Synapsis1.00
    Packaging Of Telomere Ends0.54
    Telomere clustering at the nuclear membrane0.82
    Telomere Maintenance0.38
    Meiosis0.70
    Meiotic Recombination0.32
    Chromosome Maintenance0.56
    2RSF Complex Binds the Centromere.
    RSF Complex Binds the Centromere.1.00
    Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    Nucleosome assembly1.00
    Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    3Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation1.00
    Histone modification0.31
    Signal transduction_Activin A signaling regulation0.96
    4Formation of Meiotic Holliday Junction
    Formation of Meiotic Holliday Junction1.00
    Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    Formation of Meiotic Heteroduplex0.83
    5Transcription_Sin3 and NuRD in transcription regulation
    Transcription_Sin3 and NuRD in transcription regulation1.00
    Transcription Sin3 and NuRD in transcription regulation0.96

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for HIST1H4F
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H4F
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4F
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    2 BioSystems Pathways for HIST1H4F 
        Type II interferon signaling (IFNG)
    Signaling events mediated by HDAC Class III

    5/17        Reactome Pathways for HIST1H4F (see all 17)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Disease


    1         Kegg Pathway  (Kegg details for HIST1H4F):
        Systemic lupus erythematosus


    HIST1H4F for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST1H4F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/606 Interacting proteins for HIST1H4F (P628051, 2, 3 ENSP000003669744) via UniProtKB, MINT, STRING, and/or I2D (see all 606)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3EP684312, 3, ENSP000003535814MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000353581
    HIST1H3AP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----
    GO:0045653negative regulation of megakaryocyte differentiation ----

    HIST1H4F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST1H4F:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H4F
    Search CenterWatch for drugs/clinical trials and news about HIST1H4F / H4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H4F gene: 
    NM_003540.3  

    Unigene Cluster for HIST1H4F:

    Histone cluster 1, H4f
    Hs.247816  [show with all ESTs]
    Unigene Representative Sequence: DA557005
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377745(uc003nhe.1)

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4F
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H4F:
    hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H4F (see all 4)
    OriGene shRNA RFP: HIST1H4F
    OriGene siRNA: HIST1H4F
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4F
    Sirion Biotech Custom design and validation of potent shRNA sequences against HIST1H4F 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4F (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIST1H4F (NM_003540)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4F 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H4F
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HIST1H4F
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4F

    Additional cDNA sequence: 

    BC069288.1 BC093763.1 BC093765.1 

    1 DOTS entry:

    DT.92033189 

    2 AceView cDNA sequences:

    NM_003540 BC069288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H4F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGGTAGAG
    HIST1H4F Expression
    About this image
    See HIST1H4F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H4F

    SOURCE GeneReport for Unigene cluster: Hs.247816
        SABiosciences Custom PCR Arrays for HIST1H4F

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H4F
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HIST1H4F
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4F
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4F
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H4F gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves H41 germinal histone H4 gene 84.47(n)
    100(a)
      417946  NM_001037845.1  NP_001032934.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1534091 zgc:153409 76.05(n)
    99.03(a)
      767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338771 CG33877-PA 80.91(n)
    98.06(a)
      3772211  NM_001032191.1  NP_001027362.1 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AER012C1 AER012Cp 78.96(n)
    90.29(a)
      4621072  NM_210226.1  NP_984872.1 
    soybean
    (Glycine max)
    eudicotyledons CA851345.12   -- 78.73(n)    CA851345.1 


    ENSEMBL Gene Tree for HIST1H4F (if available)
    TreeFam Gene Tree for HIST1H4F (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H4F gene
    HIST1H4I1 2  HIST1H4K1 2  HIST2H4A1 2  HIST2H4B1 2  HIST1H4J1 2  HIST1H4B1 2  HIST1H4L1 2  HIST1H4H1 2  
    HIST1H4A1 2  HIST1H4D1 2  HIST1H4E1 2  HIST1H4C1 2  HIST4H41 2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4F using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    HIST1H4F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/57 NCBI SNPs in HIST1H4F are shown (see all 57    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916243811,2
    --26238782(+) TGCTCC/TGCCCT 1 -- us2k10--------
    rs1388356861,2
    --26239192(+) TAATGC/TTGAAT 1 -- us2k10--------
    rs774122071,2
    C,F--26239299(+) TGTTAA/GTTTAC 1 -- us2k11Minor allele frequency- G:0.04EA 120
    rs1428312421,2
    --26239370(+) AGCAAC/GGTAGT 1 -- us2k10--------
    rs1826378451,2
    --26239371(+) GCAAGA/GTAGTG 1 -- us2k10--------
    rs93589131,2
    C,F,H--26239404(+) ATACAA/GTGCCA 1 -- us2k125Minor allele frequency- G:0.36EA NA NS WA 2966
    rs757319141,2
    C--26239432(+) TCTTCA/TAGCCT 1 -- us2k10--------
    rs168914741,2
    C,F--26239453(+) ATCTTT/GACACC 1 -- us2k18Minor allele frequency- G:0.13NA CSA WA EA 500
    rs1865699181,2
    --26239456(+) TTTACA/GCCTCA 1 -- us2k10--------
    rs757442981,2
    C,F--26239502(+) ACTTCA/GATTAA 1 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for HIST1H4F (26240561 - 26241021 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H4F: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H4F
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HIST1H4F for disorders           About GeneDecksing

    OMIM gene information: 602824    OMIM disorders: --

    7 diseases for HIST1H4F:    About MalaCards
    non-hodgkin lymphoma    systemic lupus erythematosus    lupus erythematosus    hodgkin's lymphoma
    hepatocellular carcinoma    immunodeficiency    carcinoma

    1 disease from the University of Copenhagen DISEASES database for HIST1H4F:
    Cancer

    Export disorders for HIST1H4F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H4F gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with HIST1H4F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W....Doenecke D. (1991)
    4. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)1, 2 Kang B....Zhang Z. (2011)
    5. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    6. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (1987)
    7. A conserved function for the H2A.Z C terminus. (PubMed id 22493515)1 Wratting D....Millar C.B. (2012)
    8. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8361 HGNC: 4783 AceView: HIST1H4F Ensembl:ENSG00000198327 euGenes: HUgn8361
    ECgene: HIST1H4F Kegg: 8361 H-InvDB: HIST1H4F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H4F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H4F gene:
    Search GeneIP for patents involving HIST1H4F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     EMD Millipore Kits and Assays for the Analysis of HIST1H4F
     EMD Millipore small molecules (inhibitor) for HIST1H4F
     EMD Millipore Purified and/or Recombinant HIST1H4F Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4F
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HIST1H4F  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H4F   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H4F  
     OriGene Protein Over-expression Lysate for HIST1H4F   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HIST1H4F   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4F   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4F  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H4F   OriGene Custom Protein Services for HIST1H4F  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST1H4F
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H4F
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4F
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4F
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4F
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4F
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H4F GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H4F
     GenScript Custom Assay Services for HIST1H4F GenScript Custom Superior Antibodies Services for HIST1H4F
     GenScript Custom overexpressing Cell Line Services for HIST1H4F CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HIST1H4F promoter
     Search Chromatin IP Primers for HIST1H4F
     RT2 qPCR Primer Assay in human, mouse / rat HIST1H4F
     GNC Network for HIST1H4F
     SABiosciences PCR Arrays including human, mouse / rat HIST1H4F
     Search Tocris compounds for HIST1H4F
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HIST1H4F lysates
     Antibodies for HIST1H4F
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H4F
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HIST1H4F Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HIST1H4F
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4F
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H4F
     SwitchGear Promoter luciferase reporter plasmids for HIST1H4F
     Search ThermoFisher Antibodies for HIST1H4F
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4F
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HIST1H4F
    Sirion Biotech Customized:
     stable knockdown cell line services for HIST1H4F
     inducible knockdown cell line services for HIST1H4F
     design and validation of potent shRNA sequences against HIST1H4F
     adenovirus for potent knockdown of HIST1H4F
     adenovirus for overexpression of HIST1H4F
     stable overexpressing cell line services for HIST1H4F
     inducible overexpressing cell line services for HIST1H4F
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST1H4F gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4