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HIST1H4E Gene

protein-coding   GIFtS: 52
GCID: GC06P026204

Histone Cluster 1, H4e

(Previous names: H4 histone family, member J, histone 1, H4e)
(Previous symbol: H4FJ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H4e1 2     H4/N3
H4FJ1 2 3 5     H4/O3
H4 Histone Family, Member J1 2     H4F23
Histone 1, H4e1 2     H4FA3
H4/j2     H4FB3
Histone H42     H4FC3
H4/A3     H4FD3
H4/B3     H4FE3
H4/C3     H4FG3
H4/D3     H4FH3
H4/E3     H4FI3
H4/G3     H4FK3
H4/H3     H4FM3
H4/I3     H4FN3
H4/J3     H4FO3
H4/K3     HIST2H43
H4/M3     

External Ids:    HGNC: 47901   Entrez Gene: 83672   Ensembl: ENSG000001985187   OMIM: 6028305   UniProtKB: P628053   

Export aliases for HIST1H4E gene to outside databases

Previous GC identifers: GC06P026263 GC06P026312 GC06P026148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H4E Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4E Gene:
HIST1H4E (histone cluster 1, H4e) is a protein-coding gene. Diseases associated with HIST1H4E include non-hodgkin lymphoma, and hodgkin's lymphoma. An important paralog of this gene is HIST1H4K.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H4E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H4E gene promoter:
         SRF   AML1a   SRF (504 AA)   Egr-1   Olf-1   XBP-1   Egr-4   GATA-1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H4E promoter sequence
   Search Chromatin IP Primers for HIST1H4E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H4E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026204:  view genomic region     (about GC identifiers)

Start:
26,204,858 bp from pter      End:
26,206,266 bp from pter
Size:
1,409 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
Selected PDB 3D structures from and Proteopedia for HIST1H4E (see all 55):
2BQZ (3D)        2CV5 (3D)        2KWN (3D)        2KWO (3D)        2LVM (3D)        2QQS (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4E: NX_P62805

Explore proteomics data for HIST1H4E at MOPED

Post-translational modifications: 

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST1H4E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003536.1  
    ENSEMBL proteins: 
     ENSP00000353624  
    Reactome Protein details: P62805

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    Cloud-Clone Corp. Proteins for HIST1H4E

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    Cloud-Clone Corp. CLIAs for HIST1H4E


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST1H4E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H4E for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H4E
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    miRNA
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    miRTarBase miRNAs that target HIST1H4E:
    hsa-mir-26a-5p (MIRT050053), hsa-mir-598-3p (MIRT040492), hsa-mir-34a-5p (MIRT025407)

    Block miRNA regulation of human, mouse, rat HIST1H4E using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HIST1H4E:
    hsa-miR-1291
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    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H4_HUMAN, P62805: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    extracellular4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST1H4E for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H4E About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H4E
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4E
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST1H4E
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    Selected Reactome Pathways for HIST1H4E (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H4E):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H4E for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H4E
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H4E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H4E (P628051, 2, 3 ENSP000003536244) via UniProtKB, MINT, STRING, and/or I2D (see all 696)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD2P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000215077P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234507P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234704P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000235307P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-templated transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST1H4E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H4E (H4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H4E gene: 
    NM_003545.3  

    Unigene Cluster for HIST1H4E:

    Histone cluster 1, H4e
    Hs.662174  [show with all ESTs]
    Unigene Representative Sequence: BF673232
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360441(uc003ngy.3)
    miRNA
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    Additional mRNA sequence: 

    AK312153.1 CR542180.1 CR542189.1 

    1 DOTS entry:

    DT.440599 

    22 AceView cDNA sequences:

    NM_003545 BC056868 BQ067875 CR542180 BC012587 BX280884 BC050615 AA379443 
    CR542189 BI834372 BI756282 AI221390 AW512812 AW963932 BU660715 BU753081 
    AA578323 AI985605 AW002185 BF673232 AA608930 BQ311536 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H4E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H4E Expression
    About this image

    HIST1H4E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H4E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.662174
        Custom PCR Arrays for HIST1H4E
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H4E gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    100(a)
    many ↔ many
    GL343466.1(310644-310955)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017331821 histone H4-like 80.91(n)
    100(a)
      101733182  XM_004916987.1  XP_004917044.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe37d092 Transcribed sequence with strong similarity to protein refNP_003535.1 (H.sapiens) H4 histone family, member I [Homo sapiens] less 82.55(n)    57061812 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG339071 His4:CG33907 80.26(n)
    99.03(a)
      3772666  NM_001032117.1  NP_001027288.1 
    worm
    (Caenorhabditis elegans)
    Secernentea his-561 his-56 75.08(n)
    99.03(a)
      178055  NM_069738.1  NP_502139.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHF1(YBR009C)4 Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity less   --   2(255684-255373) 852294  NP_009563.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G076601 AT1G07660 76.38(n)
    98.06(a)
      837279  NM_100639.2  NP_563793.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01199001 Os03g0119900 78.96(n)
    98.06(a)
      4331427  NM_001055318.1  NP_001048783.1 
            Species with no ortholog for HIST1H4E

    ENSEMBL Gene Tree for HIST1H4E (if available)
    TreeFam Gene Tree for HIST1H4E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H4E gene
    HIST1H4K2  HIST4H42  HIST2H4A2  HIST1H4F2  HIST1H4L2  HIST2H4B2  HIST1H4I2  HIST1H4B2  
    HIST1H4A2  HIST1H4H2  HIST1H4C2  HIST1H4D2  HIST1H4J2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4E using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    HIST1H4E for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for HIST1H4E (see all 132)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94612391,2
    C,F,H--26202899(+) TTGTTT/CTGCAT 1 -- us2k1 tfbs313Minor allele frequency- C:0.06NS EA WA 1768
    rs339200831,2
    C--26202932(+) AACTT-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs1511611791,2
    C--26202932(+) AACTT-/AAAAAAA 1 -- us2k10--------
    rs1451524051,2
    C--26203035(+) AAGCAC/TGTAAA 1 -- us2k10--------
    rs1169615801,2
    C,F--26203321(+) GGTACG/AAGCTA 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1865528491,2
    --26203547(+) TTTTAC/TGGCTA 1 -- us2k10--------
    rs772989451,2
    C--26203558(+) GCTTTG/TAGTCT 1 -- us2k10--------
    rs1923817281,2
    C--26203611(+) GTTCCC/TATAGC 1 -- us2k10--------
    rs1439155681,2
    C--26203624(+) GCTTCA/GGGGAA 1 -- us2k10--------
    rs133628151,2
    C,H--26203719(+) ccaacA/CCCTTT 1 -- us2k15Minor allele frequency- C:0.00NS EA NA 418

    HapMap Linkage Disequilibrium report for HIST1H4E (26204858 - 26206266 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HIST1H4E:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv375n21CNV Loss19592680
    nsv883490CNV Loss21882294
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H4E
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602830    OMIM disorders: --

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell
    NHL). Translocation t(3;6)(q27;p21), with BCL6

  • 10 diseases for HIST1H4E:    
    About MalaCards
    non-hodgkin lymphoma    hodgkin's lymphoma    breast and colorectal cancer    systemic lupus erythematosus
    hiv-1    lupus erythematosus    hepatocellular carcinoma    neuroblastoma
    colorectal cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIST1H4E:
    Cancer

    HIST1H4E for disorders           About GeneDecksing


    Export disorders for HIST1H4E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H4E gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with HIST1H4E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (Genomics 1997)
    3. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (Hum. Genet. 1997)
    4. A conserved function for the H2A.Z C terminus. (PubMed id 22493515)1 Wratting D....Millar C.B. (J. Biol. Chem. 2012)
    5. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    8. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (J Proteomics 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8367 HGNC: 4790 AceView: HIST1H4E Ensembl:ENSG00000198518 euGenes: HUgn8367
    ECgene: HIST1H4E Kegg: 8367 H-InvDB: HIST1H4E

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST1H4E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H4E gene:
    Search GeneIP for patents involving HIST1H4E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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