Aliases for HIST1H4D Gene
Aliases for HIST1H4D Gene
- Histone Cluster 1 H4 Family Member D 2 3 5
- H4 Histone Family, Member B 2 3
- Histone Cluster 1, H4d 2 3
- Histone 1, H4d 2 3
- H4/B 3 4
- H4FB 3 4
- HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
- Histone H4 3
- DJ221C16.9 3
- HIST2H4 4
- H4FA 4
- H4/A 4
- H4/C 4
- H4/D 4
- H4/E 4
- H4/G 4
- H4/H 4
- H4/I 4
External Ids for HIST1H4D Gene
- HGNC: 4782
- Entrez Gene: 8360
- Ensembl: ENSG00000277157
- OMIM: 602823
- UniProtKB: P62805
Previous HGNC Symbols for HIST1H4D Gene
- H4FB
Previous GeneCards Identifiers for HIST1H4D Gene
- GC06M026246
- GC06M026296
- GC06M026131
Summaries for HIST1H4D Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H4D Gene
HIST1H4D (Histone Cluster 1 H4 Family Member D) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4H.
UniProtKB/Swiss-Prot for HIST1H4D Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4D Gene
Genomics for HIST1H4D Gene
Regulatory Elements for HIST1H4D Gene
Enhancers for HIST1H4D Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G026162 | 0.7 | Ensembl | 12.4 | +27.6 | 27576 | 0.2 | BCOR RNF2 DPF2 MNT FOSL1 ARID1B JUND PRDM6 POLR2A IKZF1 | HIST1H4D HIST1H1PS1 HIST1H2AD HIST1H3E HIST1H2APS3 HIST1H2BF RPS10P1 HIST1H4C HIST1H4F HIST1H4H |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H4D on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H4D gene promoter:
Regulatory Element Products
Genomic Location for HIST1H4D Gene
- Chromosome:
- 6
- Start:
- 26,188,710 bp from pter
- End:
- 26,189,076 bp from pter
- Size:
- 367 bases
- Orientation:
- Minus strand
Genomic View for HIST1H4D Gene
Genes around HIST1H4D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H4D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H4D Gene
Proteins for HIST1H4D Gene
-
Protein details for HIST1H4D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for HIST1H4D Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
Protein Expression for HIST1H4D Gene
Post-translational modifications for HIST1H4D Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Sumoylated, which is associated with transcriptional repression.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H4D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST1H4D Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H4D
- Search GeneTex for Antibodies for HIST1H4D
Protein Products
- EMD Millipore Purified and/or Recombinant HIST1H4D Protein
-
OriGene Purified Proteins for HIST1H4D
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H4D
- Origene Custom Protein Services for HIST1H4D
- Search GeneTex for Proteins for HIST1H4D
Assay Products
- EMD Millipore Kits and Assays for HIST1H4D
No data available for DME Specific Peptides for HIST1H4D Gene
Domains & Families for HIST1H4D Gene
Gene Families for HIST1H4D Gene
- HGNC:
Protein Domains for HIST1H4D Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
No data available for Suggested Antigen Peptide Sequences for HIST1H4D Gene
Function for HIST1H4D Gene
Molecular function for HIST1H4D Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,TAS | 3035717 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0042393 | histone binding | IPI | 20498094 |
Phenotypes for HIST1H4D Gene
- GenomeRNAi human phenotypes for HIST1H4D:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4D gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4D gene
- Search ViGene Biosciences for HIST1H4D
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4D
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4D
- GenScript: Design CRISPR guide RNA sequences for HIST1H4D
miRNA for HIST1H4D Gene
- miRTarBase miRNAs that target HIST1H4D
miRNA Products
- Search ViGene Biosciences for HIST1H4D
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H4D
- Browse OriGene Inhibitory RNA Products For HIST1H4D
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4D gene
Clone Products
-
OriGene ORF clones in human for HIST1H4D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H4D
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H4D gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4D gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4D gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4D Gene
Localization for HIST1H4D Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4D Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IBA | -- |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST1H4D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST1H4D Gene
1 GeneTex pathway for HIST1H4D Gene
2 BioSystems pathways for HIST1H4D Gene
66 Reactome pathways for HIST1H4D Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H4D Gene
4 GeneGo (Thomson Reuters) pathways for HIST1H4D Gene
2 Qiagen pathways for HIST1H4D Gene
Interacting Proteins for HIST1H4D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
Transcripts for HIST1H4D Gene
mRNA/cDNA for HIST1H4D Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H4D Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4D
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4D
- GenScript: Design CRISPR guide RNA sequences for HIST1H4D
miRNA Products
- Search ViGene Biosciences for HIST1H4D
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H4D
- Browse OriGene Inhibitory RNA Products For HIST1H4D
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4D gene
Clone Products
-
OriGene ORF clones in human for HIST1H4D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H4D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HIST1H4D Gene
This gene is overexpressed in Whole Blood (x18.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H4D Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIST1H4D Gene:
HIST1H4DSOURCE GeneReport for Unigene cluster for HIST1H4D Gene:
Hs.248179Evidence on tissue expression from TISSUES for HIST1H4D Gene
- Liver(4.5)
- Nervous system(4.5)
- Eye(4.2)
- Blood(2.3)
- Intestine(2.3)
- Lung(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for HIST1H4D
No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4D Gene
Orthologs for HIST1H4D Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| rat (Rattus norvegicus) |
Mammalia | Hist2h4a 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC100856225 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h4m 34 16 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC748513 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC100337407 34 |
|
||
| chicken (Gallus gallus) |
Aves | HIST1H46L2 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495739 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100002181 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33891 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | his-60 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER012C 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E08647g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHF1 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01634 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hhf3 34 |
|
- Species where no ortholog for HIST1H4D was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIST1H4D Gene
Paralogs for HIST1H4D Gene
(3) SIMAP similar genes for HIST1H4D Gene using alignment to 1 proteins:
Variants for HIST1H4D Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001626140 | -- | 26,188,351(+) | ATCTC(C/T)TTTGA | downstream-variant-500B | |
| rs1002492738 | -- | 26,188,545(+) | CCAGC(A/G)TGGGC | downstream-variant-500B | |
| rs1002632495 | -- | 26,188,966(+) | GCCAG(A/G)CGGCG | reference, synonymous-codon | |
| rs1003039564 | -- | 26,189,948(+) | GGGCC(C/G)ATTGA | upstream-variant-2KB | |
| rs1003639399 | -- | 26,189,746(+) | CACCG(C/T)GCCGG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv375n21 | CNV | loss | 19592680 |
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.79;
16.56% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H4D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H4D
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4D Gene
Disorders for HIST1H4D Gene
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
Relevant External Links for HIST1H4D
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H4D
No disorders were found for HIST1H4D Gene.
No data available for MalaCards and Genatlas for HIST1H4D Gene
Publications for HIST1H4D Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 3 4 64
- Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U. … Nick H. (Science 1987) 3 4 64
- New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. (PMID: 25556234) Kipper S. … Bajorek M. (Mol. Cell Proteomics 2015) 3 64
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- GenScript: Next-day shipping cDNA ORF clone for HIST1H4D in any vector
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- GenScript Custom Assay Services for HIST1H4D
- GenScript Custom overexpressing Cell Line Services for HIST1H4D
- GenScript: Design CRISPR guide RNA sequences for HIST1H4D
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HIST1H4D
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H4D gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4D gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4D gene
- Search ViGene Biosciences for HIST1H4D
- Search Santa Cruz Biotechnology (SCBT) for HIST1H4D Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST1H4D siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4D
- Horizon Cell Lines for HIST1H4D
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST1H4D
- VectorBuilder custom plasmid, inducible vectors for HIST1H4D
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H4D
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H4D Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer