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HIST1H4D Gene

protein-coding   GIFtS: 51
GCID: GC06M026188

Histone Cluster 1, H4d

(Previous names: H4 histone family, member B, histone 1, H4d)
(Previous symbol: H4FB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H4d1 2     H4/M3
H4FB1 2 3 5     H4/N3
H4 Histone Family, Member B1 2     H4/O3
Histone 1, H4d1 2     H4F23
H4/b2     H4FA3
dJ221C16.92     H4FC3
Histone H42     H4FD3
H4/A3     H4FE3
H4/B3     H4FG3
H4/C3     H4FH3
H4/D3     H4FI3
H4/E3     H4FJ3
H4/G3     H4FK3
H4/H3     H4FM3
H4/I3     H4FN3
H4/J3     H4FO3
H4/K3     HIST2H43

External Ids:    HGNC: 47821   Entrez Gene: 83602   Ensembl: ENSG000001889877   OMIM: 6028235   UniProtKB: P628053   

Export aliases for HIST1H4D gene to outside databases

Previous GC identifers: GC06M026246 GC06M026296 GC06M026131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H4D Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4D Gene:
HIST1H4D (histone cluster 1, H4d) is a protein-coding gene. Diseases associated with HIST1H4D include non-hodgkin lymphoma, and hodgkin's lymphoma. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H4D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H4D gene promoter:
         AML1a   Egr-1   Olf-1   AP-4   XBP-1   GATA-1   FOXO4   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H4D promoter sequence
   Search Chromatin IP Primers for HIST1H4D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H4D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4D gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026188:  view genomic region     (about GC identifiers)

Start:
26,188,938 bp from pter      End:
26,189,304 bp from pter
Size:
367 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
Selected PDB 3D structures from and Proteopedia for HIST1H4D (see all 55):
2BQZ (3D)        2CV5 (3D)        2KWN (3D)        2KWO (3D)        2LVM (3D)        2QQS (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4D: NX_P62805

Explore proteomics data for HIST1H4D at MOPED

Post-translational modifications: 

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST1H4D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003530.1  
    ENSEMBL proteins: 
     ENSP00000343282  
    Reactome Protein details: P62805

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST1H4D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H4D for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H4D
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    miRNA
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    hsa-let-7a-5p (MIRT052400), hsa-mir-505-3p (MIRT041054), hsa-mir-328-3p (MIRT043825), hsa-mir-484 (MIRT041799), hsa-mir-34a-5p (MIRT025282)

    Block miRNA regulation of human, mouse, rat HIST1H4D using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H4D:
    hsa-miR-328 hsa-miR-1291
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H4_HUMAN, P62805: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    extracellular4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST1H4D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H4D About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H4D
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4D
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST1H4D
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    Selected Reactome Pathways for HIST1H4D (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H4D):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H4D for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H4D
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H4D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H4D (P628051, 2, 3 ENSP000003432824) via UniProtKB, MINT, STRING, and/or I2D (see all 697)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD2P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000215077P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234507P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234704P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000235307P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-templated transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST1H4D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H4D (H4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H4D gene: 
    NM_003539.3  

    Unigene Cluster for HIST1H4D:

    Histone cluster 1, H4d
    Hs.248179  [show with all ESTs]
    Unigene Representative Sequence: DA880613
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340756(uc003ngu.3)
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      QuantiFast Probe-based Assays in human, mouse, rat HIST1H4D

    Additional mRNA sequence: 

    BC128104.1 BC128105.1 BC143045.1 

    2 DOTS entries:

    DT.91889954  DT.95344884 

    2 AceView cDNA sequences:

    NM_003539 CA406688 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H4D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGTGGTGT
    HIST1H4D Expression
    About this image


    HIST1H4D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    HIST1H4D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H4D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248179
        Custom PCR Arrays for HIST1H4D
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    QuantiFast Probe-based Assays in human, mouse, rat HIST1H4D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIST1H4D gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h4d5
    Hist1h4m1
    histone cluster 1, H4d5
    histone cluster 1, H4m1
    82.85(n)1
    100(a)1
      13 (9.80 cM)5
    1000412301  NM_001195421.11  NP_001182350.11 
     235815985 
    chicken
    (Gallus gallus)
    Aves HIST1H46L21 histone cluster 1, H4-IV, germinal H4-like 2 (similar more 84.47(n)
    100(a)
      100858049  XM_003640368.2  XP_003640416.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H4
    100(a)
    many ↔ many
    GL343252.1(1832062-1832373)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004957391 histone H4-like 82.52(n)
    100(a)
      100495739  XM_002933894.2  XP_002933940.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000021811 histone H4-like 77.67(n)
    100(a)
      100002181  XM_001336371.5  XP_001336407.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338911 His4:CG33891 79.94(n)
    99.03(a)
      3772519  NM_001032156.1  NP_001027327.1 
    worm
    (Caenorhabditis elegans)
    Secernentea his-601 his-60 76.7(n)
    99.03(a)
      177522  NM_068802.5  NP_501203.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHF1(YBR009C)4
    HHF11
    Histone H4, core histone protein required for chromatin more4
    HHF11
    69.58(n)1
    92.23(a)1
      2(255684-255373)4
    8522941, 4  NP_009563.11, 4 


    ENSEMBL Gene Tree for HIST1H4D (if available)
    TreeFam Gene Tree for HIST1H4D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H4D gene
    HIST1H4E2  HIST1H4K2  HIST4H42  HIST2H4A2  HIST1H4F2  HIST1H4L2  HIST2H4B2  HIST1H4I2  
    HIST1H4B2  HIST1H4A2  HIST1H4H2  HIST1H4C2  HIST1H4J2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4D using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    HIST1H4D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for HIST1H4D (see all 123)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117712471,2
    C--26134308(+) CCAGCG/CTGGGC 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1121346881,2
    F--26188564(+) AGGCGG/CAGGAG 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1136439101,2
    C--26188608(+) CCTGGG/CAAACA 1 -- ds50012Minor allele frequency- C:0.04CSA EA 122
    rs782410391,2
    C--26188727(+) CGGGAG/AGCGGA 1 -- ds50013Minor allele frequency- A:0.05CSA WA NA 240
    rs1123135801,2
    F--26188738(+) GACTGC/TAGATT 1 -- ds50012Minor allele frequency- T:0.04CSA WA 120
    rs1858168281,2
    --26188772(+) TCCAGC/TATGGG 1 -- ds50010--------
    rs1145965051,2
    F--26188787(+) ACAGCA/TAGAGT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs748009251,2
    C,F--26188808(+) TTTAAT/AACACT 1 -- ds50012Minor allele frequency- A:0.03NA EA 240
    rs1906199671,2
    --26188825(+) ACCGGC/TCAGTA 1 -- ds50010--------
    rs168913781,2
    C,F,H--26188864(+) ATTTAA/GCTTGA 1 -- ds500125Minor allele frequency- G:0.16NA NS EA CSA WA 2908

    HapMap Linkage Disequilibrium report for HIST1H4D (26188938 - 26189304 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HIST1H4D:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv375n21CNV Loss19592680
    nsv883490CNV Loss21882294
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H4D
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602823    OMIM disorders: --

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell
    NHL). Translocation t(3;6)(q27;p21), with BCL6

  • 13 diseases for HIST1H4D:    
    About MalaCards
    non-hodgkin lymphoma    hodgkin's lymphoma    breast and colorectal cancer    systemic lupus erythematosus
    hiv-1    lupus erythematosus    tonsillitis    hepatocellular carcinoma
    neuroblastoma    colorectal cancer    thyroiditis    breast cancer
    cerebritis

    1 disease from the University of Copenhagen DISEASES database for HIST1H4D:
    Cancer

    HIST1H4D for disorders           About GeneDecksing


    Export disorders for HIST1H4D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H4D gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with HIST1H4D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (Genomics 1997)
    3. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (Hum. Genet. 1997)
    4. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (Science 1987)
    5. A conserved function for the H2A.Z C terminus. (PubMed id 22493515)1 Wratting D....Millar C.B. (J. Biol. Chem. 2012)
    6. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    9. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    10. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8360 HGNC: 4782 AceView: HIST1H4D Ensembl:ENSG00000188987 euGenes: HUgn8360
    ECgene: HIST1H4D Kegg: 8360 H-InvDB: HIST1H4D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST1H4D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H4D gene:
    Search GeneIP for patents involving HIST1H4D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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