Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HIST1H4C Gene

protein-coding GIFtS: 56
GCID: GC06P026104

histone cluster 1, H4c

(Previous names: H4 histone family, member G, histone 1, H4c )
(Previous symbol: H4FG)

Explore 7 diseases affiliated with
HIST1H4C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histone Cluster 1, H4c¹ ²		H4/M³
H4FG¹ ² ³ ⁵		H4/N³
H4/G³		H4/O³
DJ221C16.1¹		H4F2³
H4 Histone Family, Member G¹ ²		H4FA³
Histone 1, H4c¹ ²		H4FB³
Histone H4²		H4FC³
H4/A³		H4FD³
H4/B³		H4FE³
H4/C³		H4FH³
H4/D³		H4FI³
H4/E³		H4FJ³
H4/G³		H4FK³
H4/H³		H4FM³
H4/I³		H4FN³
H4/J³		H4FO³
H4/K³		HIST2H4³

External Ids:	HGNC: 4787¹	Entrez Gene: 8364²	Ensembl: ENSG00000197061⁷	OMIM: 602827⁵	UniProtKB: P62805³

Export aliases for HIST1H4C gene to outside databases

Previous GC identifers: GC06P026161 GC06P026212 GC06P026048

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H4C:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in

eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which

approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with

linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is

intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead

contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H4_HUMAN, P62805

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to

the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of

post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H4C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HIST1H4C gene promoter:
GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H4C promoter sequence

Search SABiosciences Chromatin IP Primers for HIST1H4C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1

HIST1H4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4C gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P026104: view genomic region (about GC identifiers)

Start:	26,104,104 bp from pter	End:	26,104,565 bp from pter
Size:	462 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)

Recommended Name: Histone H4

Size: 103 amino acids; 11367 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one

H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

Subcellular location: Nucleus. Chromosome

Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;

6/46 PDB 3D structures from and Proteopedia for HIST1H4C (see all 46):

2BQZ (3D)

2CV5 (3D)

2LVM (3D)

2RNY (3D)

2RS9 (3D)

3A6N (3D)

Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4C: NX_P62805

Post-translational modifications:

Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the

genome but not in heterochromatin¹

Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation¹

Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation

at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4

(H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage¹

Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by

SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing¹

Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone

chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4¹

Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction

between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone

H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may

function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21

methylation (H4K20me)¹

Sumoylated, which is associated with transcriptional repression¹

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,

including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active

promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with

post-meiotically activated genes on autosomes¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62805

HIST1H4C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003533.1

ENSEMBL proteins:

ENSP00000367034

Reactome Protein details: P62805
Human Recombinant Protein Products for HIST1H4C:

	EMD Millipore Purified and/or Recombinant HIST1H4C Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for HIST1H4C
	GenScript Custom Purified and Recombinant Proteins Services for HIST1H4C
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HIST1H4C

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	--	--
GO:0005576	extracellular region	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	--	--

HIST1H4C for ontologies About GeneDecksing

HIST1H4C Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4C
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HIST1H4C
	GenScript Custom Superior Antibodies Services for HIST1H4C
	Abcam antibodies for HIST1H4C
	Uscn Antibodies for HIST1H4C
	Search ThermoFisher Antibodies for HIST1H4C

Assay Products for HIST1H4C:

	EMD Millipore Kits and Assays for the Analysis of HIST1H4C
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HIST1H4C
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HIST1H4C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HIST1H4C for domains About GeneDecksing

4 InterPro domains/families:

IPR009072 Histone-fold

IPR019809 Histone_H4_CS

IPR007125 Histone_core_D

IPR001951 Histone_H4

Graphical View of Domain Structure for InterPro Entry P62805

ProtoNet protein and cluster: P62805

UniProtKB/Swiss-Prot: H4_HUMAN, P62805

Similarity: Belongs to the histone H4 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to

the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of

post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0005515	protein binding	--	--

HIST1H4C for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for HIST1H4C:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HIST1H4C

miRNA Products:		OriGene 3'-UTR Clone: HIST1H4C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4C
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H4C:
		hsa-miR-1291
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H4C (see all 4) OriGene shRNA RFP: HIST1H4C OriGene siRNA: HIST1H4C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4C
		Sirion Biotech Custom design and validation of potent shRNA sequences against HIST1H4C

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HIST1H4C
			Sirion Biotech Customized adenovirus for overexpression of HIST1H4C Sirion Biotech Customized adenovirus for potent knockdown of HIST1H4C

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4C (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4C (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HIST1H4C (NM_003542)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HIST1H4C
		Search LifeMap BioReagents cell lines for HIST1H4C
		Sirion Biotech Customized stable knockdown cell line services for HIST1H4C Sirion Biotech Customized inducible knockdown cell line services for HIST1H4C Sirion Biotech Customized stable overexpressing cell line services for HIST1H4C Sirion Biotech Customized inducible overexpressing cell line services for HIST1H4C

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4C

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal transduction Activin A signaling regulation

	Signal transduction Activin A signaling regulation	1.00			Histone modification	0.31
	Signal transduction_Activin A signaling regulation	0.96

Transcription_Sin3 and NuRD in transcription regulation

Transcription_Sin3 and NuRD in transcription regulation

1.00

Transcription Sin3 and NuRD in transcription regulation

0.96

Development_Notch Signaling Pathway

Development_Notch Signaling Pathway

1.00

Development Notch Signaling Pathway

0.97

Development NOTCH1-mediated pathway for NF-KB activity modulation

Development NOTCH1-mediated pathway for NF-KB activity modulation

1.00

Development_NOTCH1-mediated pathway for NF-KB activity modulation

0.88

Type II interferon signaling (IFNG)

Type II interferon signaling (IFNG)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for HIST1H4C

	Development Notch Signaling Pathway
	Transcription Sin3 and NuRD in transcription regulation
	Histone modification
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Signal transduction Activin A signaling regulation

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H4C

	Nuclear Receptor Activation by Vitamin-A
	Crosstalk Between CARM1 and ESRs

4 GeneGo (Thomson Reuters) Pathways for HIST1H4C

	Signal transduction Activin A signaling regulation
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription Sin3 and NuRD in transcription regulation
	Development Notch Signaling Pathway

2 BioSystems Pathways for HIST1H4C

	Type II interferon signaling (IFNG)
	Signaling events mediated by HDAC Class III

5/17 Reactome Pathways for HIST1H4C (see all 17)

	Telomere Maintenance
	Nucleosome assembly
	Cell Cycle
	RSF Complex Binds the Centromere.
	Disease

1 Kegg Pathway (Kegg details for HIST1H4C):

Systemic lupus erythematosus

HIST1H4C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HIST1H4C

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/604 Interacting proteins for HIST1H4C (P62805^{1, 2, 3} ENSP00000367034⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 604)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431²^,³	MINT-6543302 MINT-7220359 I2D: score=7
HIST1H3B	P68431²^,³	MINT-6543302 MINT-7220359 I2D: score=7
HIST1H3C	P68431²^,³	MINT-6543302 MINT-7220359 I2D: score=7
HIST1H3D	P68431²^,³	MINT-6543302 MINT-7220359 I2D: score=7
HIST1H3E	P68431²^,³	MINT-6543302 MINT-7220359 I2D: score=7

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000723	telomere maintenance	--	--
GO:0006325	chromatin organization	--	--
GO:0006334	nucleosome assembly	--	--
GO:0034080	CENP-A containing nucleosome assembly at centromere	--	--
GO:0045653	negative regulation of megakaryocyte differentiation	--	--

HIST1H4C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for HIST1H4C:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HIST1H4C
Search CenterWatch for drugs/clinical trials and news about HIST1H4C / H4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HIST1H4C gene:

NM_003542.3

Unigene Cluster for HIST1H4C:

Histone cluster 1, H4c

Hs.46423 [show with all ESTs]

Unigene Representative Sequence: BG393025

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000377803(uc003ngi.3)

miRNA Products:		OriGene 3'-UTR Clone: HIST1H4C Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H4C
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H4C:
		hsa-miR-1291
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H4C (see all 4) OriGene shRNA RFP: HIST1H4C OriGene siRNA: HIST1H4C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4C
		Sirion Biotech Custom design and validation of potent shRNA sequences against HIST1H4C

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4C (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4C (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HIST1H4C (NM_003542)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H4C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat HIST1H4C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4C

Additional cDNA sequence:

BC054014.1 BC130558.1 BC130560.1

16 DOTS entries:

DT.91800965 DT.91684300 DT.95231421 DT.91770845 DT.100809959 DT.100041907 DT.121389302 DT.91922701

DT.91706426 DT.95118537 DT.121389321 DT.91874834 DT.92003342 DT.100802479 DT.121389316 DT.91773745

24/545 AceView cDNA sequences (see all 545):

AI589002 BM955882 BG943072 AI362918 AV712095 AI870806 BG943702 BG940523

BG941058 AA255502 BF002135 BG941025 BG942565 BG941130 BG944721 AA255529

BG942967 BG943999 NM_003542 BG940012 AV759311 BG944931 BG940894 BV198255

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HIST1H4C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGTAGTAT

About this image

HIST1H4C expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HIST1H4C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIST1H4C

SOURCE GeneReport for Unigene cluster: Hs.46423

SABiosciences Custom PCR Arrays for HIST1H4C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H4C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat HIST1H4C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4C

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4C gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100858049¹	histone H4-like	80.58(n) 100(a)		100858049 XM_003640368.1 XP_003640416.1
lizard (Anolis carolinensis)	Reptilia	HIST1H4C⁶	--	100(a)	1 ↔ 1	GL343466.1(317297-317608)
zebrafish (Danio rerio)	Actinopterygii	zgc:153409¹	zgc:153409	80.26(n) 99.03(a)		767650 NM_001076590.1 NP_001070058.1
fruit fly (Drosophila melanogaster)	Insecta	His4:CG33877¹	CG33877-PA	78.32(n) 98.06(a)		3772211 NM_001032191.1 NP_001027362.1
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AER012C¹	AER012Cp	74.11(n) 90.29(a)		4621072 NM_210226.1 NP_984872.1
soybean (Glycine max)	eudicotyledons	Gma.15752²	Transcribed sequence with strong similarity to protein more	76.85(n)

ENSEMBL Gene Tree for HIST1H4C (if available)
TreeFam Gene Tree for HIST1H4C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HIST1H4C gene

HIST1H4B¹ ² HIST1H4I¹ ² HIST1H4H¹ ² HIST1H4E¹ ² HIST1H4A¹ ² HIST4H4¹ ² HIST1H4F¹ ² HIST1H4K¹ ²

HIST1H4J¹ ² HIST2H4A¹ ² HIST2H4B¹ ² HIST1H4D¹ ² HIST1H4L¹ ² HIST1H4G²

3 SIMAP similar genes for HIST1H4C using alignment to 1 protein entry: H4_HUMAN:

HIST1H4J HIST1H4H HIST1H4G

HIST1H4C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183187281^1,2		--	26102343(+)	`GCGAAC/GGAGAA`	1	--	us2k¹		0	--	--	--	--
rs188071783^1,2		--	26102354(+)	`GCCATA/GCAGAT`	1	--	us2k¹		0	--	--	--	--
rs113641425^1,2	C	--	26102362(+)	`GATTAA/GGCGAG`	1	--	us2k¹		0	--	--	--	--
rs198857^1,2	C,F,A,H	--	26102417(+)	`TCTTCG/CCAGAG`	1	--	us2k¹		13		NS EA NA WA CSA	1216
rs198856^1,2	C,F,A,H	--	26102708(+)	`GAATTG/ATCATA`	1	--	us2k¹		26		MN NS EA NA WA CSA	3324
rs139153107^1,2		--	26102753(+)	`TTAAAA/GGGCAT`	1	--	us2k¹		0	--	--	--	--
rs191297356^1,2		--	26102791(+)	`TCTCAC/GACTCT`	1	--	us2k¹		0	--	--	--	--
rs144035835^1,2		--	26102816(+)	`TAATGG/TTTGAC`	1	--	us2k¹		0	--	--	--	--
rs145952724^1,2		--	26102876(+)	`GGACAC/GTGAGT`	1	--	us2k¹		0	--	--	--	--
rs183837379^1,2		--	26103052(+)	`TCTCTC/TACAGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HIST1H4C (26104104 - 26104565 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIST1H4C: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H4C

DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HIST1H4C for disorders           About GeneDecksing

OMIM gene information: 602827    OMIM disorders: --

7 diseases for HIST1H4C:    About MalaCards

non-hodgkin lymphoma systemic lupus erythematosus lupus erythematosus hodgkin's lymphoma

hepatocellular carcinoma immunodeficiency carcinoma

1 disease from the University of Copenhagen DISEASES database for HIST1H4C:

Cancer

Human Genome Epidemiology (HuGE) Navigator: HIST1H4C (2 documents)

Export disorders for HIST1H4C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HIST1H4C gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with HIST1H4C)

Utopia: connect your pdf to the dynamic
world of online information

The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F....Maltais L.J. (2002)
Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)^{1, 2, 3} Albig W.... Doenecke D. (1997)
The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)^{1, 2} Albig W. and Doenecke D. (1997)
Association of histone H4 genes with the mammalian testis-specific H1t histone gene. (PubMed id 7626218)^{1, 2} Drabent B.... Doenecke D. (1995)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)¹ Fang Y....Shen X. (2012)
Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)¹ Zhao J....Yang P. (2011)
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)² Tan M.... Zhao Y. (2011)
Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PubMed id 21724829)² Kang B....Zhang Z. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8364	HGNC: 4787	AceView: HIST1H4C	Ensembl:ENSG00000197061	euGenes: HUgn8364
ECgene: HIST1H4C	Kegg: 8364	H-InvDB: HIST1H4C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HIST1H4C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HIST1H4C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HIST1H4C gene:
Search GeneIP for patents involving HIST1H4C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	EMD Millipore Purified and/or Recombinant HIST1H4C Protein
	EMD Millipore Kits and Assays for the Analysis of HIST1H4C
	EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4C
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore small molecules (inhibitor) for HIST1H4C

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HIST1H4C
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H4C		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H4C
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HIST1H4C		OriGene 3'-UTR Clone for HIST1H4C
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4C		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H4C
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HIST1H4C		OriGene Custom Protein Services for HIST1H4C
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST1H4C
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H4C
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4C
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H4C
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H4C
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4C

	GenScript Custom Purified and Recombinant Proteins Services for HIST1H4C		GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H4C
	GenScript Custom Assay Services for HIST1H4C		GenScript Custom Superior Antibodies Services for HIST1H4C
	GenScript Custom overexpressing Cell Line Services for HIST1H4C		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HIST1H4C promoter
	Search Chromatin IP Primers for HIST1H4C
	RT² qPCR Primer Assay in human, mouse / rat HIST1H4C
	Search GNC Networks for HIST1H4C
	SABiosciences PCR Arrays including human, mouse / rat HIST1H4C

Search Tocris compounds for HIST1H4C

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Antibodies for HIST1H4C
	See all of Abcam's Antibodies, Kits and Proteins for HIST1H4C
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HIST1H4C Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HIST1H4C

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H4C

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H4C
	SwitchGear Promoter luciferase reporter plasmids for HIST1H4C

Search ThermoFisher Antibodies for HIST1H4C

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4C

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HIST1H4C

Sirion Biotech Customized:

	stable knockdown cell line services for HIST1H4C
	inducible knockdown cell line services for HIST1H4C
	design and validation of potent shRNA sequences against HIST1H4C
	adenovirus for potent knockdown of HIST1H4C
	adenovirus for overexpression of HIST1H4C
	stable overexpressing cell line services for HIST1H4C
	inducible overexpressing cell line services for HIST1H4C

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HIST1H4C gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HIST1H4C Gene

histone cluster 1, H4c

Aliases
for HIST1H4C gene

Summaries
for HIST1H4C gene

Genomic Views
for HIST1H4C gene

Proteins
for HIST1H4C gene

Protein Domains /
Families
for HIST1H4C gene

Function
for HIST1H4C gene

Pathways & Interactions
for HIST1H4C gene

Drugs & Compounds
for HIST1H4C gene

Transcripts
for HIST1H4C gene

Expression
for HIST1H4C gene

Orthologs
for HIST1H4C gene

Paralogs
for HIST1H4C gene

Genomic Variants
for HIST1H4C gene

Disorders / Diseases
for HIST1H4C gene

Publications
for HIST1H4C gene

External Searches for HIST1H4C gene

Genome Databases showing HIST1H4C gene

Other Databases showing HIST1H4C gene

Specialized Databases showing HIST1H4C gene

Intellectual Property
for HIST1H4C gene

Products
for HIST1H4C gene

View Random Gene

HIST1H4C (Gene Symbol)
Histone Cluster 1, H4c
H4FG
H4/G
DJ221C16.1
H4 Histone Family, Member G
Histone 1, H4c
Histone H4
H4/A
H4/B
H4/C
H4/D
H4/E
H4/G
H4/H
H4/I
H4/J
H4/K
H4/M
H4/N
H4/O
H4F2
H4FA
H4FB
H4FC
H4FD
H4FE
H4FH
H4FI
H4FJ
H4FK
H4FM
H4FN
H4FO
HIST2H4

Advanced Search

Export list of displayed genes

HIST1H4C Gene

histone cluster 1, H4c

Aliasesfor HIST1H4C gene

Summariesfor HIST1H4C gene

Genomic Viewsfor HIST1H4C gene

Proteinsfor HIST1H4C gene

Protein Domains /Familiesfor HIST1H4C gene

Functionfor HIST1H4C gene

Pathways & Interactionsfor HIST1H4C gene

Drugs & Compoundsfor HIST1H4C gene

Transcriptsfor HIST1H4C gene

Expression for HIST1H4C gene

Orthologsfor HIST1H4C gene

Paralogsfor HIST1H4C gene

Genomic Variantsfor HIST1H4C gene

Disorders / Diseasesfor HIST1H4C gene

Publicationsfor HIST1H4C gene

External Searches for HIST1H4C gene

Genome Databases showing HIST1H4C gene

Other Databases showing HIST1H4C gene

Specialized Databases showing HIST1H4C gene

Intellectual Propertyfor HIST1H4C gene

Productsfor HIST1H4C gene

View Random Gene

Aliases
for HIST1H4C gene

Summaries
for HIST1H4C gene

Genomic Views
for HIST1H4C gene

Proteins
for HIST1H4C gene

Protein Domains /
Families
for HIST1H4C gene

Function
for HIST1H4C gene

Pathways & Interactions
for HIST1H4C gene

Drugs & Compounds
for HIST1H4C gene

Transcripts
for HIST1H4C gene

Expression
for HIST1H4C gene

Orthologs
for HIST1H4C gene

Paralogs
for HIST1H4C gene

Genomic Variants
for HIST1H4C gene

Disorders / Diseases
for HIST1H4C gene

Publications
for HIST1H4C gene

Intellectual Property
for HIST1H4C gene

Products
for HIST1H4C gene