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Aliases for HIST1H4C Gene

Aliases for HIST1H4C Gene

  • Histone Cluster 1, H4c 2 3 5
  • H4 Histone Family, Member G 2 3
  • Histone 1, H4c 2 3
  • H4/G 3 4
  • H4FG 3 4
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • DJ221C16.1 3
  • HIST2H4 4
  • H4FA 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4C Gene

Previous HGNC Symbols for HIST1H4C Gene

  • H4FG

Previous GeneCards Identifiers for HIST1H4C Gene

  • GC06P026161
  • GC06P026212
  • GC06P026104
  • GC06P026048
  • GC06P026109
  • GC06P026119

Summaries for HIST1H4C Gene

Entrez Gene Summary for HIST1H4C Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4C Gene

HIST1H4C (Histone Cluster 1, H4c) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4L.

UniProtKB/Swiss-Prot for HIST1H4C Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H4C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4C Gene

Genomics for HIST1H4C Gene

Regulatory Elements for HIST1H4C Gene

Promoters for HIST1H4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H4C on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HIST1H4C gene promoter:

Genomic Location for HIST1H4C Gene

Chromosome:
6
Start:
26,103,876 bp from pter
End:
26,104,337 bp from pter
Size:
462 bases
Orientation:
Plus strand

Genomic View for HIST1H4C Gene

Genes around HIST1H4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4C Gene

Proteins for HIST1H4C Gene

  • Protein details for HIST1H4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4C Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4C Gene

neXtProt entry for HIST1H4C Gene

Proteomics data for HIST1H4C Gene at MOPED

Post-translational modifications for HIST1H4C Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at Lys 32, Lys 60, Lys 78, and Lys 80
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H4C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4C Gene

Domains & Families for HIST1H4C Gene

Gene Families for HIST1H4C Gene

Protein Domains for HIST1H4C Gene

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4C: view

No data available for Suggested Antigen Peptide Sequences for HIST1H4C Gene

Function for HIST1H4C Gene

Molecular function for HIST1H4C Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes for HIST1H4C Gene

GenomeRNAi human phenotypes for HIST1H4C:
genes like me logo Genes that share phenotypes with HIST1H4C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4C Gene

Localization for HIST1H4C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H4C Gene COMPARTMENTS Subcellular localization image for HIST1H4C gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for HIST1H4C Gene

Pathways & Interactions for HIST1H4C Gene

SuperPathways for HIST1H4C Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Packaging Of Telomere Ends
genes like me logo Genes that share pathways with HIST1H4C: view

Gene Ontology (GO) - Biological Process for HIST1H4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly IEA,IDA 20498094
genes like me logo Genes that share ontologies with HIST1H4C: view

No data available for SIGNOR curated interactions for HIST1H4C Gene

Drugs & Compounds for HIST1H4C Gene

No Compound Related Data Available

Transcripts for HIST1H4C Gene

mRNA/cDNA for HIST1H4C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(545) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4C Gene

Histone cluster 1, H4c:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4C Gene

No ASD Table

Relevant External Links for HIST1H4C Gene

GeneLoc Exon Structure for
HIST1H4C
ECgene alternative splicing isoforms for
HIST1H4C

Expression for HIST1H4C Gene

mRNA expression in normal human tissues for HIST1H4C Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H4C Gene

This gene is overexpressed in Whole Blood (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H4C Gene



SOURCE GeneReport for Unigene cluster for HIST1H4C Gene Hs.46423

genes like me logo Genes that share expression patterns with HIST1H4C: view

Protein tissue co-expression partners for HIST1H4C Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST1H4C Gene

Orthologs for HIST1H4C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC526789 35
  • 79.61 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia LOC100855431 35
  • 77.99 (n)
  • 100 (a)
HIST1H4C 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist2h4 35
  • 79.94 (n)
  • 100 (a)
Hist2h4 16
Hist2h4 36
  • 100 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC465305 35
  • 81.88 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100912489 35
  • 82.2 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 100 (a)
ManyToMany
-- 36
  • 100 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HIST1H46L6 35
  • 79.94 (n)
  • 100 (a)
H4-I 36
  • 100 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hist1h4a 35
  • 80.58 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.17 35
  • 77.67 (n)
  • 100 (a)
si:ch211-113a14.26 36
  • 100 (a)
ManyToMany
si:dkey-261m9.9 36
  • 100 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003909 35
  • 77.67 (n)
  • 99.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33897 35
  • 78.32 (n)
  • 99.03 (a)
worm
(Caenorhabditis elegans)
Secernentea his-38 35
  • 77.02 (n)
  • 99.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G46320 35
  • 73.14 (n)
  • 98.06 (a)
soybean
(Glycine max)
eudicotyledons Gma.15752 35
rice
(Oryza sativa)
Liliopsida Os09g0433600 35
  • 77.35 (n)
  • 98.06 (a)
Species with no ortholog for HIST1H4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H4C Gene

ENSEMBL:
Gene Tree for HIST1H4C (if available)
TreeFam:
Gene Tree for HIST1H4C (if available)

Paralogs for HIST1H4C Gene

(3) SIMAP similar genes for HIST1H4C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H4C: view

Variants for HIST1H4C Gene

Sequence variations from dbSNP and Humsavar for HIST1H4C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs198850 -- 26,104,442(+) CGGCC(A/C)CACTG downstream-variant-500B
rs198851 -- 26,104,404(+) TGACA(G/T)CCTGC downstream-variant-500B
rs198852 -- 26,104,220(+) GCCCT(A/G)AAACG reference, synonymous-codon
rs198853 -- 26,103,868(+) CCAAC(C/T)CATGT upstream-variant-2KB
rs198854 -- 26,103,829(+) CCACT(C/T)GGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4C Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914

Variation tolerance for HIST1H4C Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H4C Gene

HapMap Linkage Disequilibrium report
HIST1H4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4C Gene

Disorders for HIST1H4C Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

Relevant External Links for HIST1H4C

Genetic Association Database (GAD)
HIST1H4C
Human Genome Epidemiology (HuGE) Navigator
HIST1H4C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H4C

No disorders were found for HIST1H4C Gene.

No data available for MalaCards and Genatlas for HIST1H4C Gene

Publications for HIST1H4C Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3
  3. Human tNASP promotes in vitro nucleosome assembly with histone H3.3. (PMID: 25615412) Kato D. … Kurumizaka H. (Biochemistry 2015) 3
  4. Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. (PMID: 24525235) Shi J. … Zhou B.P. (Cancer Cell 2014) 3
  5. Molecular functions of the TLE tetramerization domain in Wnt target gene repression. (PMID: 24596249) Chodaparambil J.V. … Weis W.I. (EMBO J. 2014) 3

Products for HIST1H4C Gene

Sources for HIST1H4C Gene

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