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Aliases for HIST1H4C Gene

Aliases for HIST1H4C Gene

  • Histone Cluster 1, H4c 2 3
  • H4FG 3 4 6
  • H4 Histone Family, Member G 2 3
  • Histone 1, H4c 2 3
  • H4/G 3 4
  • Histone H4 3
  • DJ221C16.1 3
  • HIST2H4 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4C Gene

Previous Symbols for HIST1H4C Gene

  • H4FG

Summaries for HIST1H4C Gene

Entrez Gene Summary for HIST1H4C Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H4C Gene

HIST1H4C (Histone Cluster 1, H4c) is a Protein Coding gene. Among its related pathways are Disease and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is HIST4H4.

UniProtKB/Swiss-Prot for HIST1H4C Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H4C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4C Gene

Genomics for HIST1H4C Gene

Genomic Location for HIST1H4C Gene

26,103,876 bp from pter
26,104,337 bp from pter
462 bases
Plus strand

Genomic View for HIST1H4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4C Gene

Regulatory Elements for HIST1H4C Gene

Transcription factor binding sites by QIAGEN in the HIST1H4C gene promoter:

Proteins for HIST1H4C Gene

  • Protein details for HIST1H4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H4
    Protein Accession:
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4C Gene

    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4C Gene

neXtProt entry for HIST1H4C Gene

Proteomics data for HIST1H4C Gene at MOPED

Post-translational modifications for HIST1H4C Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80

Other Protein References for HIST1H4C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4C Gene

Domains for HIST1H4C Gene

Gene Families for HIST1H4C Gene

  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H4C Gene


  • Belongs to the histone H4 family.:
    • P62805
genes like me logo Genes that share domains with HIST1H4C: view

Function for HIST1H4C Gene

Molecular function for HIST1H4C Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 3035717
GO:0005515 protein binding IPI 10220385
GO:0035575 histone demethylase activity (H4-K20 specific) TAS --
GO:0042393 histone binding IPI 20498094
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST1H4C: view

Phenotypes for HIST1H4C Gene

GenomeRNAi human phenotypes for HIST1H4C:
genes like me logo Genes that share phenotypes with HIST1H4C: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H4C Gene

Localization for HIST1H4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4C Gene

Nucleus. Chromosome.

Subcellular locations from

Jensen Localization Image for HIST1H4C Gene COMPARTMENTS Subcellular localization image for HIST1H4C gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 4

Gene Ontology (GO) - Cellular Components for HIST1H4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000786 nucleosome TAS 3035717
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 14585971
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST1H4C: view

Pathways for HIST1H4C Gene

genes like me logo Genes that share pathways with HIST1H4C: view

Gene Ontology (GO) - Biological Process for HIST1H4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000723 telomere maintenance TAS --
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly TAS --
genes like me logo Genes that share ontologies with HIST1H4C: view

Transcripts for HIST1H4C Gene

mRNA/cDNA for HIST1H4C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(545) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4C Gene

Histone cluster 1, H4c:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4C Gene

No ASD Table

Relevant External Links for HIST1H4C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIST1H4C Gene

mRNA expression in normal human tissues for HIST1H4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H4C Gene

This gene is overexpressed in Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H4C Gene

SOURCE GeneReport for Unigene cluster for HIST1H4C Gene Hs.46423

genes like me logo Genes that share expressions with HIST1H4C: view

Orthologs for HIST1H4C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
LOC465305 36
  • 81.88 (n)
  • 100 (a)
(Bos Taurus)
Mammalia LOC526789 36
  • 79.61 (n)
  • 100 (a)
(Canis familiaris)
Mammalia HIST1H4C 37
  • 100 (a)
LOC100855431 36
  • 77.99 (n)
  • 100 (a)
(Mus musculus)
Mammalia Hist1h4c 16
Hist2h4 36
  • 79.94 (n)
  • 100 (a)
Hist2h4 37
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 100 (a)
-- 37
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100912489 36
  • 82.2 (n)
  • 100 (a)
(Gallus gallus)
Aves H4-I 37
  • 100 (a)
HIST1H46L6 36
  • 79.94 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hist1h4a 36
  • 80.58 (n)
  • 100 (a)
(Danio rerio)
Actinopterygii si:ch211-113a14.17 36
  • 77.67 (n)
  • 100 (a)
si:ch211-113a14.26 37
  • 100 (a)
si:dkey-261m9.9 37
  • 100 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003909 36
  • 77.67 (n)
  • 99.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33897 36
  • 78.32 (n)
  • 99.03 (a)
(Caenorhabditis elegans)
Secernentea his-38 36
  • 77.02 (n)
  • 99.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 39
(Glycine max)
eudicotyledons Gma.15752 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G46320 36
  • 73.14 (n)
  • 98.06 (a)
(Oryza sativa)
Liliopsida Os09g0433600 36
  • 77.35 (n)
  • 98.06 (a)
Species with no ortholog for HIST1H4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H4C Gene

Gene Tree for HIST1H4C (if available)
Gene Tree for HIST1H4C (if available)

Paralogs for HIST1H4C Gene

Paralogs for HIST1H4C Gene

Selected SIMAP similar genes for HIST1H4C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H4C: view

Variants for HIST1H4C Gene

Sequence variations from dbSNP and Humsavar for HIST1H4C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs198850 -- 26,104,442(+) CGGCC(A/C)CACTG downstream-variant-500B
rs198851 -- 26,104,404(+) TGACA(G/T)CCTGC downstream-variant-500B
rs198852 -- 26,104,220(+) GCCCT(A/G)AAACG reference, synonymous-codon
rs198853 -- 26,103,868(+) CCAAC(C/T)CATGT upstream-variant-2KB
rs198854 -- 26,103,829(+) CCACT(C/T)GGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4C Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914

Relevant External Links for HIST1H4C Gene

HapMap Linkage Disequilibrium report

Disorders for HIST1H4C Gene


  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

(1) University of Copenhagen DISEASES for HIST1H4C Gene

Relevant External Links for HIST1H4C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HIST1H4C: view

Publications for HIST1H4C Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4
  3. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 3 4
  4. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U. … Nick H. (Science 1987) 3 4
  5. Association of histone H4 genes with the mammalian testis-specific H1t histone gene. (PMID: 7626218) Drabent B. … Doenecke D. (DNA Cell Biol. 1995) 3 4

Products for HIST1H4C Gene

Sources for HIST1H4C Gene

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