Aliases for HIST1H4C Gene
Aliases for HIST1H4C Gene
- Histone Cluster 1 H4 Family Member C 2 3 5
- H4 Histone Family, Member G 2 3
- Histone Cluster 1, H4c 2 3
- Histone 1, H4c 2 3
- H4/G 3 4
- H4FG 3 4
- HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
- Histone H4 3
- DJ221C16.1 3
- HIST2H4 4
- H4FA 4
- H4/A 4
- H4/B 4
- H4/C 4
- H4/D 4
- H4/E 4
- H4/H 4
- H4/I 4
External Ids for HIST1H4C Gene
- HGNC: 4787
- Entrez Gene: 8364
- Ensembl: ENSG00000197061
- OMIM: 602827
- UniProtKB: P62805
Previous HGNC Symbols for HIST1H4C Gene
- H4FG
Previous GeneCards Identifiers for HIST1H4C Gene
- GC06P026161
- GC06P026212
- GC06P026104
- GC06P026048
- GC06P026109
- GC06P026119
- GC06P026122
- GC06P026379
- GC06P026469
Summaries for HIST1H4C Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H4C Gene
HIST1H4C (Histone Cluster 1 H4 Family Member C) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4E.
UniProtKB/Swiss-Prot for HIST1H4C Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4C Gene
Genomics for HIST1H4C Gene
Regulatory Elements for HIST1H4C Gene
Enhancers for HIST1H4C Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H4C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H4C gene promoter:
Regulatory Element Products
Genomic Location for HIST1H4C Gene
- Chromosome:
- 6
- Start:
- 26,103,876 bp from pter
- End:
- 26,104,337 bp from pter
- Size:
- 462 bases
- Orientation:
- Plus strand
Genomic View for HIST1H4C Gene
Genes around HIST1H4C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H4C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H4C Gene
Proteins for HIST1H4C Gene
-
Protein details for HIST1H4C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for HIST1H4C Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
Protein Expression for HIST1H4C Gene
Post-translational modifications for HIST1H4C Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Sumoylated, which is associated with transcriptional repression.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H4C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST1H4C Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H4C
- Search GeneTex for Antibodies for HIST1H4C
Protein Products
- EMD Millipore Purified and/or Recombinant HIST1H4C Protein
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIST1H4C
- Origene Custom Protein Services for HIST1H4C
- Search GeneTex for Proteins for HIST1H4C
Assay Products
- EMD Millipore Kits and Assays for HIST1H4C
No data available for DME Specific Peptides for HIST1H4C Gene
Domains & Families for HIST1H4C Gene
Gene Families for HIST1H4C Gene
- HGNC:
Protein Domains for HIST1H4C Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
No data available for Suggested Antigen Peptide Sequences for HIST1H4C Gene
Function for HIST1H4C Gene
Molecular function for HIST1H4C Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,TAS | 3035717 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0042393 | histone binding | IPI | 20498094 |
Phenotypes for HIST1H4C Gene
- GenomeRNAi human phenotypes for HIST1H4C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4C gene
- Search ViGene Biosciences for HIST1H4C
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4C
- GenScript: Design CRISPR guide RNA sequences for HIST1H4C
miRNA for HIST1H4C Gene
- miRTarBase miRNAs that target HIST1H4C
miRNA Products
- Search ViGene Biosciences for HIST1H4C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H4C
- Browse OriGene Inhibitory RNA Products For HIST1H4C
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4C gene
Clone Products
-
OriGene ORF clones in human for HIST1H4C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H4C
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H4C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4C gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4C Gene
Localization for HIST1H4C Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4C Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IBA | -- |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST1H4C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST1H4C Gene
1 GeneTex pathway for HIST1H4C Gene
2 BioSystems pathways for HIST1H4C Gene
66 Reactome pathways for HIST1H4C Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H4C Gene
4 GeneGo (Thomson Reuters) pathways for HIST1H4C Gene
2 Qiagen pathways for HIST1H4C Gene
Interacting Proteins for HIST1H4C Gene
Selected Interacting proteins:
P62805-H4_HUMAN
ENSP00000367034
for HIST1H4C Gene via
MINT
UniProtKB
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
No data available for SIGNOR curated interactions for HIST1H4C Gene
Transcripts for HIST1H4C Gene
mRNA/cDNA for HIST1H4C Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (545) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H4C Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4C
- GenScript: Design CRISPR guide RNA sequences for HIST1H4C
miRNA Products
- Search ViGene Biosciences for HIST1H4C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H4C
- Browse OriGene Inhibitory RNA Products For HIST1H4C
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4C gene
Clone Products
-
OriGene ORF clones in human for HIST1H4C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H4C Gene
mRNA differential expression in normal tissues according to GTEx for HIST1H4C Gene
This gene is overexpressed in Whole Blood (x4.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H4C Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H4C Gene:
HIST1H4CSOURCE GeneReport for Unigene cluster for HIST1H4C Gene:
Hs.46423Evidence on tissue expression from TISSUES for HIST1H4C Gene
- Liver(5)
- Blood(4.9)
- Nervous system(4.5)
- Eye(4.2)
- Intestine(2.3)
- Kidney(2.1)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for HIST1H4C
-
OriGene qPCR primer pairs and template standards for HIST1H4C
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4C Gene
Orthologs for HIST1H4C Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | HIST1H4C 35 |
|
OneToOne | |
| LOC100855431 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToMany | |
| LOC465305 34 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | LOC100912489 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist2h4 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC526789 34 |
|
||
| chicken (Gallus gallus) |
Aves | H4-I 35 |
|
OneToMany | |
| HIST1H46L6 34 |
|
||||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hist1h4a 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-113a14.26 35 |
|
ManyToMany | |
| si:dkey-261m9.9 35 |
|
ManyToMany | |||
| si:ch211-113a14.17 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33897 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003909 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | his-38 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHF1 37 |
|
|
|
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G46320 34 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.15752 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0433600 34 |
|
- Species where no ortholog for HIST1H4C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIST1H4C Gene
Paralogs for HIST1H4C Gene
(3) SIMAP similar genes for HIST1H4C Gene using alignment to 1 proteins:
Variants for HIST1H4C Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000465875 | -- | 26,102,150(+) | CTAAT(C/G)TCTCC | upstream-variant-2KB | |
| rs1001321460 | -- | 26,103,228(+) | AAGGG(-/AAGAGT)AAGAG | upstream-variant-2KB | |
| rs1001469277 | -- | 26,103,639(+) | CTATT(C/G)CGTAA | upstream-variant-2KB | |
| rs1001605230 | -- | 26,103,891(+) | GGTCC(A/G)CCAAG | upstream-variant-2KB | |
| rs1002513130 | -- | 26,104,364(+) | AATGC(A/G)TTGCG | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608393 | CNV | gain | 21293372 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.21;
4.77% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H4C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H4C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4C Gene
Disorders for HIST1H4C Gene
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
Relevant External Links for HIST1H4C
No disorders were found for HIST1H4C Gene.
No data available for MalaCards and Genatlas for HIST1H4C Gene
Publications for HIST1H4C Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
- Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 3 4 64
Products for HIST1H4C Gene
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIST1H4C
- GenScript: Next-day shipping cDNA ORF clone for HIST1H4C in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HIST1H4C
- GenScript Custom Assay Services for HIST1H4C
- GenScript Custom overexpressing Cell Line Services for HIST1H4C
- GenScript: Design CRISPR guide RNA sequences for HIST1H4C
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HIST1H4C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H4C gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4C gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4C gene
- Search ViGene Biosciences for HIST1H4C
- Search Santa Cruz Biotechnology (SCBT) for HIST1H4C Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST1H4C siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4C
- Horizon Cell Lines for HIST1H4C
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST1H4C
- VectorBuilder custom plasmid, inducible vectors for HIST1H4C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H4C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H4C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer