Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIST1H4B Gene

protein-coding   GIFtS: 55
GCID: GC06M026027

Histone Cluster 1, H4b

(Previous names: H4 histone family, member I, histone 1, H4b)
(Previous symbol: H4FI)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histone Cluster 1, H4b1 2     H4/N3
H4FI1 2 3 5     H4/O3
H4 Histone Family, Member I1 2     H4F23
Histone 1, H4b1 2     H4FA3
H4/I2 3     H4FB3
Histone H42     H4FC3
H4/A3     H4FD3
H4/B3     H4FE3
H4/C3     H4FG3
H4/D3     H4FH3
H4/E3     H4FJ3
H4/G3     H4FK3
H4/H3     H4FM3
H4/J3     H4FN3
H4/K3     H4FO3
H4/M3     HIST2H43

External Ids:    HGNC: 47891   Entrez Gene: 83662   Ensembl: ENSG000001245297   OMIM: 6028295   UniProtKB: P628053   

Export aliases for HIST1H4B gene to outside databases

Previous GC identifers: GC06M026084 GC06M026135 GC06M025971


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIST1H4B Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4B Gene:
HIST1H4B (histone cluster 1, H4b) is a protein-coding gene. Diseases associated with HIST1H4B include hemochromatosis, and non-hodgkin lymphoma. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H4B gene promoter:
         NF-1/L   NF-1   Pax-5   Egr-4   CREB   CBF-B   CBF-A   deltaCREB   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H4B promoter sequence
   Search Chromatin IP Primers for HIST1H4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026027:  view genomic region     (about GC identifiers)

Start:
26,027,124 bp from pter      End:
26,027,480 bp from pter
Size:
357 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
Selected PDB 3D structures from and Proteopedia for HIST1H4B (see all 55):
2BQZ (3D)        2CV5 (3D)        2KWN (3D)        2KWO (3D)        2LVM (3D)        2QQS (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4B: NX_P62805

Explore proteomics data for HIST1H4B at MOPED

Post-translational modifications: 

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST1H4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003535.1  
    ENSEMBL proteins: 
     ENSP00000366581  
    Reactome Protein details: P62805

    HIST1H4B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant HIST1H4B Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HIST1H4B
    OriGene Protein Over-expression Lysate for HIST1H4B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HIST1H4B
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H4B
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H4B

    HIST1H4B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4B
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST1H4B
    Abcam antibodies for HIST1H4B
    Cloud-Clone Corp. Antibodies for HIST1H4B
    Search ThermoFisher Antibodies for HIST1H4B
    Search LSBio for Antibodies for HIST1H4B

    HIST1H4B Assay Products:

    EMD Millipore Kits and Assays for the Analysis of HIST1H4B
    OriGene Custom Assay Services for HIST1H4B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H4B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H4B
    Cloud-Clone Corp. CLIAs for HIST1H4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST1H4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H4B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HIST1H4B:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H4B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H4B

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST1H4B:
    hsa-mir-615-3p (MIRT039962), hsa-mir-16-5p (MIRT051273), hsa-mir-589-5p (MIRT037787), hsa-mir-1226-3p (MIRT036412), hsa-mir-34a-5p (MIRT025461)

    Block miRNA regulation of human, mouse, rat HIST1H4B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HIST1H4B:
    hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIST1H4B
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H4B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST1H4B

    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H4B (see all 5)
    OriGene ORF clones in mouse, rat for HIST1H4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H4B (NM_003544)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST1H4B
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H4B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    H4_HUMAN, P62805: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    extracellular4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST1H4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HIST1H4B About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H4B
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4B
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST1H4B
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III

    Selected Reactome Pathways for HIST1H4B (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H4B):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H4B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H4B
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H4B (P628051, 2, 3 ENSP000003665814) via UniProtKB, MINT, STRING, and/or I2D (see all 700)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD2P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000215077P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234507P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234704P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000235307P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-templated transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST1H4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H4B (H4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIST1H4B gene: 
    NM_003544.2  

    Unigene Cluster for HIST1H4B:

    Histone cluster 1, H4b
    Hs.143080  [show with all ESTs]
    Unigene Representative Sequence: BG723905
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377364(uc003nfr.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIST1H4B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HIST1H4B:
    hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIST1H4B
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H4B
    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H4B (see all 5)
    OriGene ORF clones in mouse, rat for HIST1H4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H4B (NM_003544)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HIST1H4B
      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4B
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H4B

    Additional mRNA sequence: BC069467.1 

    2 DOTS entries:

    DT.206311  DT.121312285 

    8 AceView cDNA sequences:

    BC069467 NM_003544 BX102654 AI218900 AA287446 AA642479 AA732317 N41747 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIST1H4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTGGTTT
    HIST1H4B Expression
    About this image


    HIST1H4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    HIST1H4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143080
        Custom PCR Arrays for HIST1H4B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HIST1H4B
    QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4B
    QuantiFast Probe-based Assays in human, mouse, rat HIST1H4B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H4B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h4b5
    Hist4h41
    histone cluster 1, H4b5
    histone cluster 4, H41
    81.23(n)1
    100(a)1
      13 (9.91 cM)5
    3203321  NM_175652.21  NP_783583.11 
     237570135 
    chicken
    (Gallus gallus)
    Aves HIST1H46L31 histone cluster 1, H4-IV, germinal H4-like 3 (similar more 82.2(n)
    100(a)
      770005  XM_004937669.1  XP_004937726.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H4
    100(a)
    1 → many
    GL343279.1(558066-558377)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004967581 histone H4-like 80.91(n)
    100(a)
      100496758  XM_002943098.2  XP_002943144.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003326681 histone H4-like 80.91(n)
    100(a)
      100332668  XM_002666918.2  XP_002666964.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338711 His4:CG33871 79.29(n)
    99.03(a)
      3772708  NM_001032206.1  NP_001027377.1 
    soybean
    (Glycine max)
    eudicotyledons 444854782   -- 77.81(n)  


    ENSEMBL Gene Tree for HIST1H4B (if available)
    TreeFam Gene Tree for HIST1H4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIST1H4B gene
    HIST1H4E2  HIST1H4K2  HIST4H42  HIST2H4A2  HIST1H4F2  HIST1H4L2  HIST2H4B2  HIST1H4I2  
    HIST1H4A2  HIST1H4H2  HIST1H4C2  HIST1H4D2  HIST1H4J2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4B using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    HIST1H4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIST1H4B (see all 134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870140151,2
    --26026642(+) CTCAAC/TTAGAA 1 -- ds50010--------
    rs1504434981,2
    C--26026665(+) GCTTCC/TGGCGC 1 -- ds50010--------
    rs1382250101,2
    --26026704(+) GGTGTA/TACCAG 1 -- ds50010--------
    rs1893922831,2
    --26026748(+) GTCAGA/GTACGC 1 -- ds50010--------
    rs757158881,2
    C,F--26026794(+) CTACTC/GAGTTC 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs1495994451,2
    --26026820(+) TTAGGC/TTCTCG 1 -- ds50010--------
    rs1813653441,2
    --26026822(+) AGGCTC/TTCGTA 1 -- ds50010--------
    rs1856433531,2
    --26026844(+) CAACTA/CGTTTT 1 -- ds50010--------
    rs1465516881,2
    C--26026949(+) ACTTAC/TCTCGG 1 -- ds50010--------
    rs749435001,2
    C,F--26026970(+) TACTTA/GGCTGA 1 -- ds50011Minor allele frequency- G:0.10EA 120

    HapMap Linkage Disequilibrium report for HIST1H4B (26027124 - 26027480 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H4B
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602829    OMIM disorders: --

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell
    NHL). Translocation t(3;6)(q27;p21), with BCL6

  • 11 diseases for HIST1H4B:    
    About MalaCards
    hemochromatosis    non-hodgkin lymphoma    hodgkin's lymphoma    breast and colorectal cancer
    systemic lupus erythematosus    hiv-1    lupus erythematosus    hepatocellular carcinoma
    neuroblastoma    colorectal cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIST1H4B:
    Cancer

    HIST1H4B for disorders           About GeneDecksing


    Export disorders for HIST1H4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIST1H4B gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with HIST1H4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (Genomics 1997)
    3. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (Hum. Genet. 1997)
    4. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2 Albig W.... Doenecke D. (Genomics 1991)
    5. A conserved function for the H2A.Z C terminus. (PubMed id 22493515)1 Wratting D....Millar C.B. (J. Biol. Chem. 2012)
    6. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    9. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    10. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (J Proteomics 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8366 HGNC: 4789 AceView: HIST1H4B Ensembl:ENSG00000124529 euGenes: HUgn8366
    ECgene: HIST1H4B Kegg: 8366 H-InvDB: HIST1H4B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIST1H4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIST1H4B gene:
    Search GeneIP for patents involving HIST1H4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant HIST1H4B Protein
     EMD Millipore Kits and Assays for the Analysis of HIST1H4B
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4B
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HIST1H4B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HIST1H4B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HIST1H4B  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H4B   OriGene Purified Protein for HIST1H4B  
     OriGene ORF clones in mouse, rat for HIST1H4B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H4B   OriGene Custom Protein Services for HIST1H4B  

     
     
     Block miRNA regulation of human, mouse, rat HIST1H4B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIST1H4B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H4B Predesigned siRNA for gene silencing in human, mouse, rat HIST1H4B
     QuantiFast Probe-based Assays in human, mouse, rat HIST1H4B QuantiTect SYBR Green Assays in human, mouse, rat HIST1H4B
     Custom PCR Arrays for HIST1H4B Search Chromatin IP Primers for HIST1H4B
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HIST1H4B  Search GeneGlobe Interaction Network for HIST1H4B
     Regulatory tfbs in HIST1H4B promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H4B GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H4B
     GenScript Custom Assay Services for HIST1H4B GenScript Custom overexpressing Cell Line Services for HIST1H4B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HIST1H4B (H4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for HIST1H4B
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H4B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIST1H4B
     Antibodies for HIST1H4B
     ELISAs for HIST1H4B
     CLIAs for HIST1H4B



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H4B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H4B
     SwitchGear Promoter luciferase reporter plasmids for HIST1H4B
     Search ThermoFisher Antibodies for HIST1H4B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H4B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H4B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H4B
     Search LSBio for Antibodies for HIST1H4B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST1H4B gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4