Aliases for HIST1H4A Gene
Aliases for HIST1H4A Gene
- Histone Cluster 1 H4 Family Member A 2 3 5
- H4 Histone Family, Member A 2 3
- Histone Cluster 1, H4a 2 3
- Histone 1, H4a 2 3
- H4FA 3 4
- HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
- Histone H4 3
- HIST2H4 4
- H4/A 4
- H4/B 4
- H4/C 4
- H4/D 4
- H4/E 4
- H4/G 4
- H4/H 4
- H4/I 4
- H4/J 4
- H4/K 4
External Ids for HIST1H4A Gene
- HGNC: 4781
- Entrez Gene: 8359
- Ensembl: ENSG00000278637
- OMIM: 602822
- UniProtKB: P62805
Previous HGNC Symbols for HIST1H4A Gene
- H4FA
Previous GeneCards Identifiers for HIST1H4A Gene
- GC06P026079
- GC06P026084
- GC06P026129
- GC06P025964
Summaries for HIST1H4A Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H4A Gene
HIST1H4A (Histone Cluster 1 H4 Family Member A) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4C.
UniProtKB/Swiss-Prot for HIST1H4A Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4A Gene
Genomics for HIST1H4A Gene
Regulatory Elements for HIST1H4A Gene
Enhancers for HIST1H4A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G025535 | 1 | FANTOM5 | 4.6 | -486.1 | -486129 | 0.0 | PKNOX1 ATF1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 SMARCB1 SMARCA4 | LOC101928663 RPL21P68 CARMIL1 LOC100533655 CMAHP HIST1H4A HIST1H3B HIST1H4B HIST1H2AB HIST1H3A |
| GH06G026120 | 2.1 | FANTOM5 Ensembl ENCODE dbSUPER | 1.7 | +102.3 | 102296 | 7.8 | CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 SSRP1 | ABT1 ENSG00000272462 HMGN4 NUP50P2 ZNF322 HFE BTN3A2 HIST1H1C HIST1H2APS5 BTN3A1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H4A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST1H4A Gene
- Chromosome:
- 6
- Start:
- 26,021,679 bp from pter
- End:
- 26,022,050 bp from pter
- Size:
- 372 bases
- Orientation:
- Plus strand
Genomic View for HIST1H4A Gene
Genes around HIST1H4A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H4A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H4A Gene
Proteins for HIST1H4A Gene
-
Protein details for HIST1H4A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for HIST1H4A Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
Protein Expression for HIST1H4A Gene
Post-translational modifications for HIST1H4A Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Sumoylated, which is associated with transcriptional repression.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and posLast=8080
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H4A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST1H4A Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H4A
- Cell Signaling Technology (CST) Antibodies for HIST1H4A (H4)
-
Custom Antibody ServicesOriGene Antibodies for HIST1H4A
- Invitrogen Antibodies for HIST1H4A
- GeneTex HIST1H4A antibody for HIST1H4A
Protein Products
- EMD Millipore Purified and/or Recombinant HIST1H4A Protein
-
OriGene Purified Proteins for HIST1H4A
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H4A
- Origene Custom Protein Services for HIST1H4A
- Search GeneTex for Proteins for HIST1H4A
Assay Products
- EMD Millipore Kits and Assays for HIST1H4A
- Cell Signaling Technology (CST) Sandwich ELISA Kits for HIST1H4A (H4)
No data available for DME Specific Peptides for HIST1H4A Gene
Domains & Families for HIST1H4A Gene
Gene Families for HIST1H4A Gene
- HGNC:
Protein Domains for HIST1H4A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H4A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
Function for HIST1H4A Gene
Molecular function for HIST1H4A Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,TAS | 3035717 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0042393 | histone binding | IPI | 20498094 |
Phenotypes for HIST1H4A Gene
- GenomeRNAi human phenotypes for HIST1H4A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4A gene
- Search ViGene Biosciences for HIST1H4A
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4A
miRNA for HIST1H4A Gene
- miRTarBase miRNAs that target HIST1H4A
miRNA Products
- Search ViGene Biosciences for HIST1H4A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H4A
- Browse OriGene Inhibitory RNA Products For HIST1H4A
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4A gene
Clone Products
-
OriGene ORF clones in human for HIST1H4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H4A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H4A
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H4A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4A gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4A Gene
Localization for HIST1H4A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4A Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IBA | -- |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST1H4A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST1H4A Gene
1 GeneTex pathway for HIST1H4A Gene
1 Cell Signaling Technology pathway for HIST1H4A Gene
2 BioSystems pathways for HIST1H4A Gene
66 Reactome pathways for HIST1H4A Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H4A Gene
4 GeneGo (Thomson Reuters) pathways for HIST1H4A Gene
2 Qiagen pathways for HIST1H4A Gene
Interacting Proteins for HIST1H4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
No data available for SIGNOR curated interactions for HIST1H4A Gene
Transcripts for HIST1H4A Gene
mRNA/cDNA for HIST1H4A Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H4A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H4A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4A
miRNA Products
- Search ViGene Biosciences for HIST1H4A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H4A
- Browse OriGene Inhibitory RNA Products For HIST1H4A
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4A gene
Clone Products
-
OriGene ORF clones in human for HIST1H4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H4A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H4A Gene
mRNA differential expression in normal tissues according to GTEx for HIST1H4A Gene
This gene is overexpressed in Whole Blood (x4.8) and Brain - Cerebellum (x4.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H4A Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H4A Gene:
HIST1H4ASOURCE GeneReport for Unigene cluster for HIST1H4A Gene:
Hs.248178Evidence on tissue expression from TISSUES for HIST1H4A Gene
- Liver(4.5)
- Nervous system(4.4)
- Eye(4.2)
- Blood(2.3)
- Lung(2.2)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for HIST1H4A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4A Gene
Orthologs for HIST1H4A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h4d 34 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hist1h4m 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC748532 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC516742 34 |
|
||
| chicken (Gallus gallus) |
Aves | HIST1H46L5 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495257 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100005308 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33887 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | his-67 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.2281 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0549900 34 |
|
- Species where no ortholog for HIST1H4A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIST1H4A Gene
Paralogs for HIST1H4A Gene
(3) SIMAP similar genes for HIST1H4A Gene using alignment to 1 proteins:
Variants for HIST1H4A Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs747622981 | A breast cancer sample | ||||
| rs1001751186 | -- | 26,021,009(+) | ATTGG(A/G)AGCAC | downstream-variant-500B, upstream-variant-2KB | |
| rs1003023837 | -- | 26,021,387(+) | TTTAC(A/G)TTTAA | downstream-variant-500B, upstream-variant-2KB | |
| rs1004059208 | -- | 26,021,135(+) | CAGGA(G/T)TTCGG | downstream-variant-500B, upstream-variant-2KB | |
| rs1004310398 | -- | 26,021,224(+) | TAATC(C/T)CAGCT | downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv509122 | CNV | insertion | 20534489 |
Residual Variation Intolerance Score:
70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.81% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H4A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H4A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4A Gene
Disorders for HIST1H4A Gene
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
Relevant External Links for HIST1H4A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H4A
No disorders were found for HIST1H4A Gene.
No data available for MalaCards and Genatlas for HIST1H4A Gene
Publications for HIST1H4A Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
- BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q. … Shipp M.A. (Mol. Cell 2009) 3 4 64
- SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. (PMID: 15964846) Yin Y. … Zhu G. (J. Biol. Chem. 2005) 3 4 64
- Histone sumoylation is associated with transcriptional repression. (PMID: 14578449) Shiio Y. … Eisenman R.N. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
Products for HIST1H4A Gene
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- Browse OriGene Inhibitory RNA Products For HIST1H4A
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- OriGene CRISPR knockouts for HIST1H4A
- OriGene ORF clones in human for HIST1H4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIST1H4A
- GenScript: Next-day shipping cDNA ORF clone for HIST1H4A in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HIST1H4A
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- GenScript Custom overexpressing Cell Line Services for HIST1H4A
- Browse GenScript CRISPR for HIST1H4A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HIST1H4A
- Cell Signaling Technology (CST) Antibodies for HIST1H4A (H4)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for HIST1H4A (H4)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for HIST1H4A
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H4A gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST1H4A gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIST1H4A gene
- Search ViGene Biosciences for HIST1H4A
- Search Santa Cruz Biotechnology (SCBT) for HIST1H4A Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST1H4A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H4A
- Horizon Cell Lines for HIST1H4A
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST1H4A
- VectorBuilder custom plasmid, inducible vectors for HIST1H4A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H4A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H4A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer