HIST1H4A Gene

Aliases
for HIST1H4A gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06P026079 GC06P026084 GC06P026129 GC06P025964

Summaries
for HIST1H4A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for HIST1H4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NC_018917.2  NT_007592.16  

SwitchGear Promoter luciferase reporter plasmid: HIST1H4A promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H4A

HIST1H4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026021:  view genomic region     (about GC identifiers)

Proteins
for HIST1H4A gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Selected PDB 3D structures from and Proteopedia for HIST1H4A (see all 55):

2BQZ (3D)        2CV5 (3D)        2KWN (3D)        2KWO (3D)        2LVM (3D)        2QQS (3D)    

Explore the universe of human proteins at neXtProt for HIST1H4A: NX_P62805

Explore proteomics data for HIST1H4A at MOPED

Post-translational modifications: 

HIST1H4A Human Recombinant Protein Products:

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	antibodies-online peptides for HIST1H4A

HIST1H4A Antibody Products:

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HIST1H4A Assay Products:

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	antibodies-online kits for HIST1H4A (3 products)

Domains /
Families
for HIST1H4A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P62805

Find genes that share domains with HIST1H4A           About GenesLikeMe

Function
for HIST1H4A gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for HIST1H4A

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HIST1H4A

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4A

Localization
for HIST1H4A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytoskeleton	4
extracellular	4

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Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

Pathways & Interactions
for HIST1H4A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for HIST1H4A About   (see all 15)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	RNA Polymerase I Promoter Opening	RNA Polymerase I Transcription 0.78 Mitotic Prophase 0.56 RNA Polymerase I Chain Elongation 0.78 Systemic lupus erythematosus 0.40 RNA Polymerase I Promoter Clearance 0.78 Chromatin organization 0.34 RNA Polymerase I Promoter Opening 0.78 Chromatin modifying enzymes 0.34
2	Packaging Of Telomere Ends	Packaging Of Telomere Ends 0.66 Chromosome Maintenance 0.62 Meiotic Synapsis 0.66 Nucleosome assembly 0.59 DNA Damage/Telomere Stress Induced Senescence 0.65 Deposition of New CENPA-containing Nucleosomes at the Centromere 0.59 Telomere Maintenance 0.64 Signal transduction Activin A signaling regulation 0.40
3	Cellular Senescence	Cellular Senescence 0.81 Oxidative Stress Induced Senescence 0.64 Cellular responses to stress 0.81 Senescence-Associated Secretory Phenotype (SASP) 0.57
4	Cell Cycle, Mitotic	Cell Cycle, Mitotic 0.90 M Phase 0.62 Cell Cycle 0.90
5	Development NOTCH1-mediated pathway for NF-KB activity modulation	Development NOTCH1-mediated pathway for NF-KB activity modulation 0.55 Transcription Sin3 and NuRD in transcription regulation 0.31 Development Notch Signaling Pathway 0.55

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H4A

	Nuclear Receptor Activation by Vitamin-A
	Crosstalk Between CARM1 and ESRs

1 Cell Signaling Technology (CST) Pathway for HIST1H4A

Chromatin Regulation / Acetylation

4 GeneGo (Thomson Reuters) Pathways for HIST1H4A

	Signal transduction Activin A signaling regulation
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription Sin3 and NuRD in transcription regulation
	Development Notch Signaling Pathway

3 BioSystems Pathways for HIST1H4A

	Type II interferon signaling (IFNG)
	Gastric cancer network 1
	Signaling events mediated by HDAC Class III

Selected Reactome Pathways for HIST1H4A

	HATs acetylate histones
	NoRC negatively regulates rRNA expression
	formation of the beta-catenin:TCF transactivating complex
	PRC2 methylates histones and DNA
	RNA Polymerase I Chain Elongation

3 Kegg Pathways  (Kegg details for HIST1H4A)

	Alcoholism
	Viral carcinogenesis
	Systemic lupus erythematosus

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for HIST1H4A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for HIST1H4A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for HIST1H4A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HIST1H4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H4A
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4A

Orthologs
for HIST1H4A gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for HIST1H4A gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for HIST1H4A gene

HIST1H4E²  HIST1H4K²  HIST4H4²  HIST2H4A²  HIST1H4F²  HIST1H4L²  HIST2H4B²  HIST1H4I²  

HIST1H4B²  HIST1H4H²  HIST1H4C²  HIST1H4D²  HIST1H4J²  HIST1H4G²  

3 SIMAP similar genes for HIST1H4A using alignment to 1 protein entry:     H4_HUMAN:

HIST1H4J    HIST1H4H    HIST1H4G

Find genes that share paralogs with HIST1H4A           About GenesLikeMe

Genomic Variants
for HIST1H4A gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HIST1H4A (see all 49)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0362064		A breast cancer sample4	--	see VAR_036206	2	E Q	mis4		0	--	--	--	--
rs94676641,2	C,F,A,H	--	26021813(+)	GTCTCT/AGTGTC	1	--	us2k1		17		NS EA NA WA CSA	794
rs412667791,2	C,F	--	26021872(+)	CTATTC/TTCTCA	1	--	us2k1		1		NA	120
rs1435521601,2	C,F	--	26021913(+)	TGTCTG/TGACGT	2	G *	stg1		1		NA	4544
rs746426291,2	C,F	--	26021945(+)	GGTAAG/AGGGGG	2	/K	syn1		4		NA EA EU	6111
rs1410116121,2	C,F	--	26021963(+)	CGCCAC/TCGCAA	2	H	syn1		1		NA	4548
rs1390659351,2	C	--	26021999(+)	ATCACC/TAAGCC	2	T	syn1		1		NA	4546
rs1433002861,2	C,F	--	26022142(+)	CAAGCG/CCAAGA	2	/P /R	mis1		2		NA EU	5875
rs1471055351,2	C	--	26022157(+)	CACTGC/TCATGG	2	A V	mis1		1		NA	4552
rs2016059271,2		--	26022206(+)	TATGGC/TTTTGG	2	G	syn1		0	--	--	--	--

HapMap Linkage Disequilibrium report for HIST1H4A (26021907 - 26022278 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HIST1H4A:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv509122	CNV	Insertion	20534489
nsv428137	CNV	Loss	18775914

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HIST1H4A

DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4A

Disorders / Diseases
for HIST1H4A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for HIST1H4A gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F.... Maltais L.J. (Genomics 2002)
2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)^{1, 2, 3} Albig W.... Doenecke D. (Genomics 1997)
3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)^{1, 2} Yan Q....Shipp M.A. (Mol. Cell 2009)
4. SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. (PubMed id 15964846)^{1, 2} Yin Y.... Zhu G. (J. Biol. Chem. 2005)
5. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)^{1, 2} Shiio Y. and Eisenman R.N. (Proc. Natl. Acad. Sci. U.S.A. 2003)
6. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. (PubMed id 11387442)^{1, 2} Wang H.... Zhang Y. (Science 2001)
7. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)^{1, 2} Albig W. and Doenecke D. (Hum. Genet. 1997)
8. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)^{1, 2} Pauli U.... Nick H. (Science 1987)
9. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)¹ Vigodner M....Callaway M. (Hum. Reprod. 2013)
10. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)¹ Bett J.S....Hay R.T. (Biochem. J. 2013)

External Searches for HIST1H4A gene

Genome Databases showing HIST1H4A gene

Other Databases showing HIST1H4A gene

Specialized Databases showing HIST1H4A gene

Products
for HIST1H4A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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