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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H4A Gene

protein-coding   GIFtS: 58
GCID: GC06P026021

Histone Cluster 1, H4a

(Previous names: H4 histone family, member A, histone 1, H4a)
(Previous symbol: H4FA)
Microbiology & Infectious Diseases Congress
  11 related diseases
at
MalaCards
 

Aliases
for HIST1H4A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Histone Cluster 1, H4a1 2     H4/N3
H4FA1 2 3 5     H4/O3
H4 Histone Family, Member A1 2     H4F23
Histone 1, H4a1 2     H4FB3
Histone H42     H4FC3
H4/A3     H4FD3
H4/B3     H4FE3
H4/C3     H4FG3
H4/D3     H4FH3
H4/E3     H4FI3
H4/G3     H4FJ3
H4/H3     H4FK3
H4/I3     H4FM3
H4/J3     H4FN3
H4/K3     H4FO3
H4/M3     HIST2H43

External Ids:    HGNC: 47811   Entrez Gene: 83592   Ensembl: ENSG000001961767   OMIM: 6028225   UniProtKB: P628053   

Export aliases for HIST1H4A gene to outside databases

Previous GC identifers: GC06P026079 GC06P026084 GC06P026129 GC06P025964


Summaries
for HIST1H4A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H4A Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4A Gene: 
HIST1H4A (histone cluster 1, H4a) is a protein-coding gene. Diseases associated with HIST1H4A include kaposi's sarcoma, and non-hodgkin lymphoma, and among its related super-pathways are Signal transduction Activin A signaling regulation and Development NOTCH1-mediated pathway for NF-KB activity modulation. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H4A Gene


Genomic Views
for HIST1H4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H4A gene promoter:
         Pax-5   CBF-C   Egr-4   CREB   CBF-B   CBF-A   deltaCREB   CP1A   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H4A promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026021:  view genomic region     (about GC identifiers)

Start:
 26,021,907 bp from pter      End:
 26,022,278 bp from pter
Size:
 372 bases      Orientation:
 plus strand

Proteins
for HIST1H4A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
6/46 PDB 3D structures from and Proteopedia for HIST1H4A (see all 46):
2BQZ (3D)        2CV5 (3D)        2LVM (3D)        2RNY (3D)        2RS9 (3D)        3A6N (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4A: NX_P62805

Explore proteomics data for HIST1H4A at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin
  • UniProtKB: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation
  • UniProtKB: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage
  • UniProtKB: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing
  • UniProtKB: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H4
  • UniProtKB: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)
  • UniProtKB: Sumoylated, which is associated with transcriptional repression
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62805

    • HIST1H4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H4A Protein Expression
    REFSEQ proteins: NP_003529.1  
    ENSEMBL proteins: 
     ENSP00000352980  
    Reactome Protein details: P62805
    Human Recombinant Protein Products for HIST1H4A: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H4A 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    HIST1H4A for ontologies           About GeneDecksing



    HIST1H4A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4A
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    Abcam antibodies for HIST1H4A
    Cloud-Clone Corp. Antibodies for HIST1H4A 
    ThermoFisher Antibody for HIST1H4A
    LSBio Antibodies in human, mouse, rat for HIST1H4A 

    Assay Products for HIST1H4A: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H4A 
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    Protein Domains /
    Families
    for HIST1H4A gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    HIST1H4A for domains           About GeneDecksing


    Function
    for HIST1H4A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H4A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H4A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H4A 
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    miRNA
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    hsa-miR-1291
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Pathways & Interactions
    for HIST1H4A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H4A About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation0.31
    		Histone modification0.31
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    		Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    		Transcription Sin3 and NuRD in transcription regulation0.35
    		Development Notch Signaling Pathway0.54
    3Alcoholism
    		Alcoholism0.34
    		Systemic lupus erythematosus0.34
    4Apoptotic Pathways in Synovial Fibroblasts
    		Nuclear Receptor Activation by Vitamin-A0.57
    5Assembly of RNA Polymerase-II Initiation Complex
    		Crosstalk Between CARM1 and ESRs0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for HIST1H4A
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H4A
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for HIST1H4A
        Chromatin Regulation / Acetylation

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4A
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST1H4A
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III


    5/11        Reactome Pathways for HIST1H4A (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H4A):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H4A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/649 Interacting proteins for HIST1H4A (P628051, 2, 3 ENSP000003529804) via UniProtKB, MINT, STRING, and/or I2D (see all 649)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3EP684312, 3, ENSP000003535814MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000353581
    HIST1H3BP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3CP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3DP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H3FP684312, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    HIST1H4A for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H4A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HIST1H4A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H4A (H4)

    Search CenterWatch for drugs/clinical trials and news about HIST1H4A / H4

    Transcripts
    for HIST1H4A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H4A gene: 
    NM_003538.3  

    Unigene Cluster for HIST1H4A:

    Histone cluster 1, H4a
    Hs.248178  [show with all ESTs]
    Unigene Representative Sequence: EL736384
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000359907(uc003nfq.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    BC066248.1 BC066249.1 BC067495.1 BC069654.1 

    1 DOTS entry:

    DT.102820592 

    24 AceView cDNA sequences:

    BC066248 CF272007 BC069654 CF272019 BC067495 CF272017 NM_003538 BC066249 
    CF272026 CF272009 CF272013 CF272015 CF272023 CF272011 CF272021 CF272005 
    CF272006 CF272022 CF272016 CF272014 CF272010 BM749204 CF272018 CF272012 

    GeneLoc Exon Structure


    Expression
    for HIST1H4A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H4A expression in normal human tissues (normalized intensities)      HIST1H4A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H4A Expression
    About this image


    HIST1H4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             seminal vesicle ; glandular cells   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             ovary ; follicle cells   
             oocyte   

    See HIST1H4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H4A

    SOURCE GeneReport for Unigene cluster: Hs.248178
        SABiosciences Custom PCR Arrays for HIST1H4A
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    Orthologs
    for HIST1H4A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H4A gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hist1h4a5 histone cluster 1, H4a   --   13 (9.91 cM) 23760692 
    chicken
    (Gallus gallus)    		 Aves LOC7701421 histone H4-like 87.38(n)
    100(a)    		   770142  XM_001233179.2  XP_001233180.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HIST1H4I6
    HIST1H4I6
    (see all 3)    		 Histone H4
    (see all 3)    		 100(a)
    100(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 GL343279.1(558066-558377)
    GL343279.1(548091-548402)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1534091 zgc:153409 78.32(n)
    99.03(a)    		   767650  NM_001076590.1  NP_001070058.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta His4:CG338771 CG33877-PA 80.26(n)
    98.06(a)    		   3772211  NM_001032191.1  NP_001027362.1 
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_AER012C1 AER012Cp 80.26(n)
    90.29(a)    		   4621072  NM_210226.1  NP_984872.1 
    soybean
    (Glycine max)    		 eudicotyledons 444926452   -- 80.12(n)  


    ENSEMBL Gene Tree for HIST1H4A (if available)
    TreeFam Gene Tree for HIST1H4A (if available)

    Paralogs
    for HIST1H4A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H4A gene
    HIST1H4I1 2  HIST1H4K1 2  HIST1H4J1 2  HIST1H4L1 2  HIST1H4B1 2  HIST2H4A1 2  HIST2H4B1 2  HIST4H41 2  
    HIST1H4D1 2  HIST1H4E1 2  HIST1H4H1 2  HIST1H4F1 2  HIST1H4C1 2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4A using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4L    HIST1H4H    HIST1H4G

    HIST1H4A for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H4A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/49 SNPs in HIST1H4A are shown (see all 49)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0362064
    		A breast cancer sample4--see VAR_0362062 E Q mis40--------
    rs94676641,2
    		C,F,A,H--26021813(+) GTCTCT/AGTGTC 1 -- us2k117Minor allele frequency- A:0.16NS EA NA WA CSA 794
    rs412667791,2
    		C,F--26021872(+) CTATTC/TTCTCA 1 -- us2k11Minor allele frequency- T:0.12NA 120
    rs1435521601,2
    		C,F--26021913(+) TGTCTG/TGACGT 2 G * stg11Minor allele frequency- T:0.00NA 4544
    rs746426291,2
    		C,F--26021945(+) GGTAAG/AGGGGG 2 /K syn14Minor allele frequency- A:0.00NA EA EU 6111
    rs1410116121,2
    		C,F--26021963(+) CGCCAC/TCGCAA 2 H syn11Minor allele frequency- T:0.00NA 4548
    rs1390659351,2
    		C--26021999(+) ATCACC/TAAGCC 2 T syn11Minor allele frequency- T:0.00NA 4546
    rs1433002861,2
    		C,F--26022142(+) CAAGCG/CCAAGA 2 /P /R mis12Minor allele frequency- C:0.00NA EU 5875
    rs1471055351,2
    		C--26022157(+) CACTGC/TCATGG 2 A V mis11Minor allele frequency- T:0.00NA 4552
    rs2016059271,2
    		--26022206(+) TATGGC/TTTTGG 2 G syn10--------

    HapMap Linkage Disequilibrium report for HIST1H4A (26021907 - 26022278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H4A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

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    Disorders / Diseases
    for HIST1H4A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 602822    OMIM disorders: --

    11 diseases for HIST1H4A:    About MalaCards
    kaposi's sarcoma    non-hodgkin lymphoma    hodgkin's lymphoma    systemic lupus erythematosus
    hepatitis c    lupus erythematosus    sarcoma    hepatocellular carcinoma
    thyroiditis    hepatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIST1H4A:
    Cancer

    HIST1H4A for disorders           About GeneDecksing


    Export disorders for HIST1H4A gene to outside databases

    Publications
    for HIST1H4A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H4A gene, integrated from 9 sources (see all 174):
    (articles sorted by number of sources associating them with HIST1H4A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)1, 2 Yan Q....Shipp M.A. (2009)
    4. SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. (PubMed id 15964846)1, 2 Yin Y....Zhu G. (2005)
    5. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (2003)
    6. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. (PubMed id 11387442)1, 2 Wang H....Zhang Y. (2001)
    7. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    8. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (1987)
    9. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (2013)
    10. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)

    External Searches for HIST1H4A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H4A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8359 HGNC: 4781 AceView: HIST1H4A Ensembl:ENSG00000196176 euGenes: HUgn8359
    ECgene: HIST1H4A Kegg: 8359 H-InvDB: HIST1H4A

    Other Databases showing HIST1H4A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H4A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H4A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H4A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H4A gene:
    Search GeneIP for patents involving HIST1H4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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