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HIST1H4A Gene

protein-coding   GIFtS: 57
GCID: GC06P026021

Histone Cluster 1, H4a

(Previous names: H4 histone family, member A, histone 1, H4a)
(Previous symbol: H4FA)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H4a1 2     H4/N3
H4FA1 2 3 5     H4/O3
H4 Histone Family, Member A1 2     H4F23
Histone 1, H4a1 2     H4FB3
Histone H42     H4FC3
H4/A3     H4FD3
H4/B3     H4FE3
H4/C3     H4FG3
H4/D3     H4FH3
H4/E3     H4FI3
H4/G3     H4FJ3
H4/H3     H4FK3
H4/I3     H4FM3
H4/J3     H4FN3
H4/K3     H4FO3
H4/M3     HIST2H43

External Ids:    HGNC: 47811   Entrez Gene: 83592   Ensembl: ENSG000001961767   OMIM: 6028225   UniProtKB: P628053   

Export aliases for HIST1H4A gene to outside databases

Previous GC identifers: GC06P026079 GC06P026084 GC06P026129 GC06P025964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H4A Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4A Gene:
HIST1H4A (histone cluster 1, H4a) is a protein-coding gene. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H4A gene promoter:
         Pax-5   CBF-C   Egr-4   CREB   CBF-B   CBF-A   deltaCREB   CP1A   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H4A promoter sequence
   Search Chromatin IP Primers for HIST1H4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026021:  view genomic region     (about GC identifiers)

Start:
26,021,907 bp from pter      End:
26,022,278 bp from pter
Size:
372 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
Selected PDB 3D structures from and Proteopedia for HIST1H4A (see all 55):
2BQZ (3D)        2CV5 (3D)        2KWN (3D)        2KWO (3D)        2LVM (3D)        2QQS (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4A: NX_P62805

Explore proteomics data for HIST1H4A at MOPED

Post-translational modifications: 

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of
    the genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors
    acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation
    on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is
    performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the
    histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of
    H3.1-H41
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of
    histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still
    unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such
    as H4 Lys-21 methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST1H4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003529.1  
    ENSEMBL proteins: 
     ENSP00000352980  
    Reactome Protein details: P62805

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    Search eBioscience for ELISAs for HIST1H4A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    Find genes that share domains with HIST1H4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    Find genes that share ontologies with HIST1H4A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H4A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H4A

    miRNA
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    miRTarBase miRNAs that target HIST1H4A:
    hsa-mir-34a-5p (MIRT025252)

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    1 qRT-PCR Assays for microRNA that regulate HIST1H4A:
    hsa-miR-1291
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    Sino Biological Human cDNA Clone for HIST1H4A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H4_HUMAN, P62805: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    extracellular4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus ----

    Find genes that share ontologies with HIST1H4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H4A About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50


    Find genes that share SuperPaths with HIST1H4A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H4A
        Nuclear Receptor Activation by Vitamin-A
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for HIST1H4A
        Chromatin Regulation / Acetylation

    4 GeneGo (Thomson Reuters) Pathways for HIST1H4A
        Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    3 BioSystems Pathways for HIST1H4A
        Type II interferon signaling (IFNG)
    Gastric cancer network 1
    Signaling events mediated by HDAC Class III


    Selected Reactome Pathways for HIST1H4A (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H4A):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H4A
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H4A (P628051, 2, 3 ENSP000003529804) via UniProtKB, MINT, STRING, and/or I2D (see all 708)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD2P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000215077P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000234704P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    ENSG00000235307P254401, 2, 3EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3 
    HIST1H3EP684312, 3, ENSP000003535814MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000353581
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance ----
    GO:0006325chromatin organization ----
    GO:0006334nucleosome assembly ----
    GO:0006352DNA-templated transcription, initiation ----
    GO:0034080CENP-A containing nucleosome assembly at centromere ----

    Find genes that share ontologies with HIST1H4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H4A (H4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST1H4A gene: 
    NM_003538.3  

    Unigene Cluster for HIST1H4A:

    Histone cluster 1, H4a
    Hs.248178  [show with all ESTs]
    Unigene Representative Sequence: EL736384
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000359907(uc003nfq.3)
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      QuantiFast Probe-based Assays in human, mouse, rat HIST1H4A

    Additional mRNA sequence: 

    BC066248.1 BC066249.1 BC067495.1 BC069654.1 

    1 DOTS entry:

    DT.102820592 

    24 AceView cDNA sequences:

    BC069654 NM_003538 CF272019 BC066248 CF272017 CF272007 BC066249 BC067495 
    CF272026 CF272009 CF272021 CF272005 CF272011 CF272013 CF272023 CF272015 
    CF272022 CF272006 CF272016 CF272014 CF272010 CF272018 BM749204 CF272012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H4A Expression
    About this image

    HIST1H4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248178
        Custom PCR Arrays for HIST1H4A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H4A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h4a5
    Hist1h4d1
    histone cluster 1, H4a5
    histone cluster 1, H4d1
    86.73(n)1
    100(a)1
      13 (9.91 cM)5
    3191561  NM_175654.11  NP_783585.11 
     237606925 
    chicken
    (Gallus gallus)
    Aves HIST1H46L51 histone cluster 1, H4-IV, germinal H4-like 5 (similar more 87.06(n)
    100(a)
      770079  XM_001233094.3  XP_001233095.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H4
    100(a)
    many ↔ many
    GL343252.1(1832062-1832373)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004952571 histone H4-like 80.26(n)
    100(a)
      100495257  XM_002933891.2  XP_002933937.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000053081 histone H4-like 80.26(n)
    100(a)
      100005308  XM_001339564.4  XP_001339600.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta His4:CG338871 His4:CG33887 80.58(n)
    99.03(a)
      3772509  NM_001032166.1  NP_001027337.1 
    worm
    (Caenorhabditis elegans)
    Secernentea his-671 his-67 76.7(n)
    99.03(a)
      188792  NM_060240.4  NP_492641.1 
    soybean
    (Glycine max)
    eudicotyledons 444926452   -- 80.12(n)  
    rice
    (Oryza sativa)
    Liliopsida Os07g05499001 Os07g0549900 83.5(n)
    98.06(a)
      9270544  NM_001188321.1  NP_001175250.1 


    ENSEMBL Gene Tree for HIST1H4A (if available)
    TreeFam Gene Tree for HIST1H4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H4A gene
    HIST1H4E2  HIST1H4K2  HIST4H42  HIST2H4A2  HIST1H4F2  HIST1H4L2  HIST2H4B2  HIST1H4I2  
    HIST1H4B2  HIST1H4H2  HIST1H4C2  HIST1H4D2  HIST1H4J2  HIST1H4G2  
    3 SIMAP similar genes for HIST1H4A using alignment to 1 protein entry:     H4_HUMAN:
    HIST1H4J    HIST1H4H    HIST1H4G

    Find genes that share paralogs with HIST1H4A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H4A (see all 49)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362064
    A breast cancer sample4--see VAR_0362062 E Q mis40--------
    rs94676641,2
    C,F,A,H--26021813(+) GTCTCT/AGTGTC 1 -- us2k117Minor allele frequency- A:0.16NS EA NA WA CSA 794
    rs412667791,2
    C,F--26021872(+) CTATTC/TTCTCA 1 -- us2k11Minor allele frequency- T:0.12NA 120
    rs1435521601,2
    C,F--26021913(+) TGTCTG/TGACGT 2 G * stg11Minor allele frequency- T:0.00NA 4544
    rs746426291,2
    C,F--26021945(+) GGTAAG/AGGGGG 2 /K syn14Minor allele frequency- A:0.00NA EA EU 6111
    rs1410116121,2
    C,F--26021963(+) CGCCAC/TCGCAA 2 H syn11Minor allele frequency- T:0.00NA 4548
    rs1390659351,2
    C--26021999(+) ATCACC/TAAGCC 2 T syn11Minor allele frequency- T:0.00NA 4546
    rs1433002861,2
    C,F--26022142(+) CAAGCG/CCAAGA 2 /P /R mis12Minor allele frequency- C:0.00NA EU 5875
    rs1471055351,2
    C--26022157(+) CACTGC/TCATGG 2 A V mis11Minor allele frequency- T:0.00NA 4552
    rs2016059271,2
    --26022206(+) TATGGC/TTTTGG 2 G syn10--------

    HapMap Linkage Disequilibrium report for HIST1H4A (26021907 - 26022278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H4A
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602822    OMIM disorders: --

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell
    NHL). Translocation t(3;6)(q27;p21), with BCL6

  • 1 disease from the University of Copenhagen DISEASES database for HIST1H4A:
    Cancer

    Find genes that share disorders with HIST1H4A           About GenesLikeMe


    Export disorders for HIST1H4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H4A gene, integrated from 10 sources (see all 176):
    (articles sorted by number of sources associating them with HIST1H4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (Genomics 1997)
    3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)1, 2 Yan Q....Shipp M.A. (Mol. Cell 2009)
    4. SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. (PubMed id 15964846)1, 2 Yin Y.... Zhu G. (J. Biol. Chem. 2005)
    5. Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)1, 2 Shiio Y. and Eisenman R.N. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. (PubMed id 11387442)1, 2 Wang H.... Zhang Y. (Science 2001)
    7. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (Hum. Genet. 1997)
    8. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)1, 2 Pauli U.... Nick H. (Science 1987)
    9. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (Hum. Reprod. 2013)
    10. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8359 HGNC: 4781 AceView: HIST1H4A Ensembl:ENSG00000196176 euGenes: HUgn8359
    ECgene: HIST1H4A Kegg: 8359 H-InvDB: HIST1H4A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H4A gene:
    Search GeneIP for patents involving HIST1H4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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