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Aliases for HIST1H4A Gene

Aliases for HIST1H4A Gene

  • Histone Cluster 1, H4a 2 3 5
  • H4 Histone Family, Member A 2 3
  • Histone 1, H4a 2 3
  • H4FA 3 4
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • HIST2H4 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4A Gene

Previous HGNC Symbols for HIST1H4A Gene

  • H4FA

Previous GeneCards Identifiers for HIST1H4A Gene

  • GC06P026079
  • GC06P026084
  • GC06P026129
  • GC06P025964

Summaries for HIST1H4A Gene

Entrez Gene Summary for HIST1H4A Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4A Gene

HIST1H4A (Histone Cluster 1, H4a) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is HIST1H4C.

UniProtKB/Swiss-Prot for HIST1H4A Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4A Gene

Genomics for HIST1H4A Gene

Regulatory Elements for HIST1H4A Gene

Promoters for HIST1H4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H4A on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H4A Gene

Chromosome:
6
Start:
26,021,679 bp from pter
End:
26,022,050 bp from pter
Size:
372 bases
Orientation:
Plus strand

Genomic View for HIST1H4A Gene

Genes around HIST1H4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4A Gene

Proteins for HIST1H4A Gene

  • Protein details for HIST1H4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4A Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4A Gene

neXtProt entry for HIST1H4A Gene

Proteomics data for HIST1H4A Gene at MOPED

Post-translational modifications for HIST1H4A Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at Lys 32, Lys 60, Lys 78, and Lys 80
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HIST1H4A (H4)
  • Cloud-Clone Corp. Antibodies for HIST1H4A

No data available for DME Specific Peptides for HIST1H4A Gene

Domains & Families for HIST1H4A Gene

Gene Families for HIST1H4A Gene

Protein Domains for HIST1H4A Gene

Suggested Antigen Peptide Sequences for HIST1H4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4A: view

Function for HIST1H4A Gene

Molecular function for HIST1H4A Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST1H4A: view

miRNA for HIST1H4A Gene

miRTarBase miRNAs that target HIST1H4A

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4A Gene

Localization for HIST1H4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H4A Gene COMPARTMENTS Subcellular localization image for HIST1H4A gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for HIST1H4A Gene

Pathways & Interactions for HIST1H4A Gene

SuperPathways for HIST1H4A Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Packaging Of Telomere Ends
genes like me logo Genes that share pathways with HIST1H4A: view

Gene Ontology (GO) - Biological Process for HIST1H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly IEA,IDA 20498094
genes like me logo Genes that share ontologies with HIST1H4A: view

No data available for SIGNOR curated interactions for HIST1H4A Gene

Drugs & Compounds for HIST1H4A Gene

No Compound Related Data Available

Transcripts for HIST1H4A Gene

mRNA/cDNA for HIST1H4A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4A Gene

Histone cluster 1, H4a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4A Gene

No ASD Table

Relevant External Links for HIST1H4A Gene

GeneLoc Exon Structure for
HIST1H4A
ECgene alternative splicing isoforms for
HIST1H4A

Expression for HIST1H4A Gene

mRNA expression in normal human tissues for HIST1H4A Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H4A Gene

This gene is overexpressed in Whole Blood (x4.8) and Brain - Cerebellum (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HIST1H4A Gene



SOURCE GeneReport for Unigene cluster for HIST1H4A Gene Hs.248178

genes like me logo Genes that share expression patterns with HIST1H4A: view

Protein tissue co-expression partners for HIST1H4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST1H4A Gene

Orthologs for HIST1H4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC516742 35
  • 83.17 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist1h4d 35
  • 86.73 (n)
  • 100 (a)
Hist1h4d 16
chimpanzee
(Pan troglodytes)
Mammalia LOC748532 35
  • 84.14 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Hist1h4m 35
  • 85.76 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves HIST1H46L5 35
  • 87.06 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495257 35
  • 80.26 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005308 35
  • 80.26 (n)
  • 100 (a)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33887 35
  • 80.58 (n)
  • 99.03 (a)
worm
(Caenorhabditis elegans)
Secernentea his-67 35
  • 76.7 (n)
  • 99.03 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2281 35
rice
(Oryza sativa)
Liliopsida Os07g0549900 35
  • 83.5 (n)
  • 98.06 (a)
Species with no ortholog for HIST1H4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H4A Gene

ENSEMBL:
Gene Tree for HIST1H4A (if available)
TreeFam:
Gene Tree for HIST1H4A (if available)

Paralogs for HIST1H4A Gene

(3) SIMAP similar genes for HIST1H4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H4A: view

Variants for HIST1H4A Gene

Sequence variations from dbSNP and Humsavar for HIST1H4A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036206 A breast cancer sample
rs3734528 -- 26,022,016(+) CTTGC(A/C/G)TTTCT utr-variant-3-prime
rs9467664 -- 26,021,585(+) GTCTC(A/T)GTGTC upstream-variant-2KB
rs34391493 -- 26,022,420(+) AAAAA(A/C)CCATC downstream-variant-500B
rs41266779 -- 26,021,644(+) CTATT(C/T)TCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4A Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
nsv509122 CNV Insertion 20534489

Variation tolerance for HIST1H4A Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H4A Gene

HapMap Linkage Disequilibrium report
HIST1H4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4A Gene

Disorders for HIST1H4A Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

Relevant External Links for HIST1H4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H4A

No disorders were found for HIST1H4A Gene.

No data available for MalaCards and Genatlas for HIST1H4A Gene

Publications for HIST1H4A Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3
  3. Human tNASP promotes in vitro nucleosome assembly with histone H3.3. (PMID: 25615412) Kato D. … Kurumizaka H. (Biochemistry 2015) 3
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for HIST1H4A Gene

Sources for HIST1H4A Gene

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