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Set Analyses:

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HIST1H4A Gene

protein-coding GIFtS: 57
GCID: GC06P026021

Histone Cluster 1, H4a

(Previous names: H4 histone family, member A, histone 1, H4a)
(Previous symbol: H4FA)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Histone Cluster 1, H4a¹ ²		H4/N³
H4FA¹ ² ³ ⁵		H4/O³
H4 Histone Family, Member A¹ ²		H4F2³
Histone 1, H4a¹ ²		H4FB³
Histone H4²		H4FC³
H4/A³		H4FD³
H4/B³		H4FE³
H4/C³		H4FG³
H4/D³		H4FH³
H4/E³		H4FI³
H4/G³		H4FJ³
H4/H³		H4FK³
H4/I³		H4FM³
H4/J³		H4FN³
H4/K³		H4FO³
H4/M³		HIST2H4³

External Ids:	HGNC: 4781¹	Entrez Gene: 8359²	Ensembl: ENSG00000196176⁷	OMIM: 602822⁵	UniProtKB: P62805³

Export aliases for HIST1H4A gene to outside databases

Previous GC identifers: GC06P026079 GC06P026084 GC06P026129 GC06P025964

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H4A Gene:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in

eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which

approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts

with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.

This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA

tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster

on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H4A Gene:

HIST1H4A (histone cluster 1, H4a) is a protein-coding gene. Diseases associated with HIST1H4A include cockayne syndrome, and kaposi's sarcoma. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot: H4_HUMAN, P62805

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA

accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role

in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is

regulated via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling

Gene Wiki entry for HIST1H4A Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000006.12 NC_018917.2 NT_007592.16

Regulatory elements:

Regulatory transcription factor binding sites in the HIST1H4A gene promoter:
Pax-5 CBF-C Egr-4 CREB CBF-B CBF-A deltaCREB CP1A Pax-4a CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H4A promoter sequence

Search Chromatin IP Primers for HIST1H4A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H4A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1

HIST1H4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4A gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P026021: view genomic region (about GC identifiers)

Start:	26,021,907 bp from pter	End:	26,022,278 bp from pter
Size:	372 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)

Recommended Name: Histone H4

Size: 103 amino acids; 11367 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one

H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;

Selected PDB 3D structures from and Proteopedia for HIST1H4A (see all 55):

2BQZ (3D)

2CV5 (3D)

2KWN (3D)

2KWO (3D)

2LVM (3D)

2QQS (3D)

Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4A: NX_P62805

Explore proteomics data for HIST1H4A at MOPED

Post-translational modifications:

Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of

the genome but not in heterochromatin¹

Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation¹

Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors

acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation

on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage¹

Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is

performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing¹

Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the

histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of

H3.1-H4¹

Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction

between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of

histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still

unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such

as H4 Lys-21 methylation (H4K20me)¹

Sumoylated, which is associated with transcriptional repression¹

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic

cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks

active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with

post-meiotically activated genes on autosomes¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See HIST1H4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003529.1

ENSEMBL proteins:

ENSP00000352980

Reactome Protein details: P62805

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

HIST: Histones / Replication-dependent

4 InterPro protein domains:

IPR009072 Histone-fold

IPR019809 Histone_H4_CS

IPR007125 Histone_core_D

IPR001951 Histone_H4

Graphical View of Domain Structure for InterPro Entry P62805

ProtoNet protein and cluster: P62805

UniProtKB/Swiss-Prot: H4_HUMAN, P62805

Similarity: Belongs to the histone H4 family

HIST1H4A for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: H4_HUMAN, P62805

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA

accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role

in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is

regulated via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0005515	protein binding	--	--
GO:0046982	protein heterodimerization activity	--	--

HIST1H4A for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H4A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

H4_HUMAN, P62805: Nucleus. Chromosome

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytoskeleton	4
extracellular	4

About this image

Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	--	--
GO:0005576	extracellular region	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	--	--
GO:0005730	nucleolus	--	--

HIST1H4A for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HIST1H4A About (see all 15)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Packaging Of Telomere Ends

Packaging Of Telomere Ends	0.66	Nucleosome assembly	0.59
Meiotic Synapsis	0.66	Deposition of New CENPA-containing Nucleosomes at the Centromere	0.59
DNA Damage/Telomere Stress Induced Senescence	0.65	Signal transduction Activin A signaling regulation	0.40
Telomere Maintenance	0.64	Histone modification	0.31

RNA Polymerase I Promoter Opening

RNA Polymerase I Transcription	0.78	Mitotic Prophase	0.56
RNA Polymerase I Chain Elongation	0.78	Systemic lupus erythematosus	0.40
RNA Polymerase I Promoter Clearance	0.78	Chromatin modifying enzymes	0.34
RNA Polymerase I Promoter Opening	0.78	HATs acetylate histones	0.34

Cellular Senescence

	Cellular Senescence	0.81			Oxidative Stress Induced Senescence	0.64
	Cellular responses to stress	0.81			Senescence-Associated Secretory Phenotype (SASP)	0.57

Cell Cycle, Mitotic

	Cell Cycle, Mitotic	0.90			M Phase	0.62
	Cell Cycle	0.90

Development NOTCH1 mediated pathway for NF KB activity modulation

	Development NOTCH1 mediated pathway for NF KB activity modulation	0.50			Transcription Sin3 and NuRD in transcription regulation	0.35
	Development Notch Signaling Pathway	0.50

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H4A

	Nuclear Receptor Activation by Vitamin-A
	Crosstalk Between CARM1 and ESRs

1 Cell Signaling Technology (CST) Pathway for HIST1H4A

Chromatin Regulation / Acetylation

4 GeneGo (Thomson Reuters) Pathways for HIST1H4A

	Signal transduction Activin A signaling regulation
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription Sin3 and NuRD in transcription regulation
	Development Notch Signaling Pathway

3 BioSystems Pathways for HIST1H4A

	Type II interferon signaling (IFNG)
	Gastric cancer network 1
	Signaling events mediated by HDAC Class III

Selected Reactome Pathways for HIST1H4A (see all 16)

	HATs acetylate histones
	NoRC negatively regulates rRNA expression
	formation of the beta-catenin:TCF transactivating complex
	PRC2 methylates histones and DNA
	RNA Polymerase I Chain Elongation

3 Kegg Pathways (Kegg details for HIST1H4A):

	Alcoholism
	Viral carcinogenesis
	Systemic lupus erythematosus

HIST1H4A for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for HIST1H4A
Interactions:

Search GeneGlobe Interaction Network for HIST1H4A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for HIST1H4A (P62805^{1, 2, 3} ENSP00000352980⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 708)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BRD2	P25440¹^,²^,³	EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3
ENSG00000215077	P25440¹^,²^,³	EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3
ENSG00000234704	P25440¹^,²^,³	EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3
ENSG00000235307	P25440¹^,²^,³	EBI-302023,EBI-2874802 MINT-7989882 MINT-7989539 MINT-7989824 MINT-7989846 MINT-7989865 I2D: score=3
HIST1H3E	P68431²^,³, ENSP00000353581⁴	MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000353581

About this table

Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000723	telomere maintenance	--	--
GO:0006325	chromatin organization	--	--
GO:0006334	nucleosome assembly	--	--
GO:0006352	DNA-templated transcription, initiation	--	--
GO:0034080	CENP-A containing nucleosome assembly at centromere	--	--

HIST1H4A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for HIST1H4A (H4)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HIST1H4A gene:

NM_003538.3

Unigene Cluster for HIST1H4A:

Histone cluster 1, H4a

Hs.248178 [show with all ESTs]

Unigene Representative Sequence: EL736384

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000359907(uc003nfq.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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Additional mRNA sequence:

BC066248.1 BC066249.1 BC067495.1 BC069654.1

1 DOTS entry:

DT.102820592

24 AceView cDNA sequences:

BC069654 NM_003538 CF272019 BC066248 CF272017 CF272007 BC066249 BC067495

CF272026 CF272009 CF272021 CF272005 CF272011 CF272013 CF272023 CF272015

CF272022 CF272006 CF272016 CF272014 CF272010 CF272018 BM749204 CF272012

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HIST1H4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

HIST1H4A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

HIST1H4A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.248178

Custom PCR Arrays for HIST1H4A

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4A gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hist1h4a⁵ Hist1h4d¹	histone cluster 1, H4a⁵ histone cluster 1, H4d¹	86.73(n)¹ 100(a)¹		13 (9.91 cM)⁵ 319156¹ NM_175654.1¹ NP_783585.1¹ 23760692⁵
chicken (Gallus gallus)	Aves	HIST1H46L5¹	histone cluster 1, H4-IV, germinal H4-like 5 (similar more	87.06(n) 100(a)		770079 XM_001233094.3 XP_001233095.1
lizard (Anolis carolinensis)	Reptilia	--	Histone H4	100(a)	many ↔ many	GL343252.1(1832062-1832373)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC100495257¹	histone H4-like	80.26(n) 100(a)		100495257 XM_002933891.2 XP_002933937.1
zebrafish (Danio rerio)	Actinopterygii	LOC100005308¹	histone H4-like	80.26(n) 100(a)		100005308 XM_001339564.4 XP_001339600.2
fruit fly (Drosophila melanogaster)	Insecta	His4:CG33887¹	His4:CG33887	80.58(n) 99.03(a)		3772509 NM_001032166.1 NP_001027337.1
worm (Caenorhabditis elegans)	Secernentea	his-67¹	his-67	76.7(n) 99.03(a)		188792 NM_060240.4 NP_492641.1
soybean (Glycine max)	eudicotyledons	44492645²	--	80.12(n)
rice (Oryza sativa)	Liliopsida	Os07g0549900¹	Os07g0549900	83.5(n) 98.06(a)		9270544 NM_001188321.1 NP_001175250.1

ENSEMBL Gene Tree for HIST1H4A (if available)
TreeFam Gene Tree for HIST1H4A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HIST1H4A gene

HIST1H4E² HIST1H4K² HIST4H4² HIST2H4A² HIST1H4F² HIST1H4L² HIST2H4B² HIST1H4I²

HIST1H4B² HIST1H4H² HIST1H4C² HIST1H4D² HIST1H4J² HIST1H4G²

3 SIMAP similar genes for HIST1H4A using alignment to 1 protein entry: H4_HUMAN:

HIST1H4J HIST1H4H HIST1H4G

HIST1H4A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036206⁴		A breast cancer sample⁴	--	see VAR_036206	2	E Q	mis⁴		0	--	--	--	--
rs9467664^1,2	C,F,A,H	--	26021813(+)	`GTCTCT/AGTGTC`	1	--	us2k¹		17		NS EA NA WA CSA	794
rs41266779^1,2	C,F	--	26021872(+)	`CTATTC/TTCTCA`	1	--	us2k¹		1		NA	120
rs143552160^1,2	C,F	--	26021913(+)	`TGTCTG/TGACGT`	2	G *	stg¹		1		NA	4544
rs74642629^1,2	C,F	--	26021945(+)	`GGTAAG/AGGGGG`	2	/K	syn¹		4		NA EA EU	6111
rs141011612^1,2	C,F	--	26021963(+)	`CGCCAC/TCGCAA`	2	H	syn¹		1		NA	4548
rs139065935^1,2	C	--	26021999(+)	`ATCACC/TAAGCC`	2	T	syn¹		1		NA	4546
rs143300286^1,2	C,F	--	26022142(+)	`CAAGCG/CCAAGA`	2	/P /R	mis¹		2		NA EU	5875
rs147105535^1,2	C	--	26022157(+)	`CACTGC/TCATGG`	2	A V	mis¹		1		NA	4552
rs201605927^1,2		--	26022206(+)	`TATGGC/TTTTGG`	2	G	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HIST1H4A (26021907 - 26022278 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for HIST1H4A: About this table

Variant ID	Type	Subtype	PubMed ID
nsv509122	CNV	Insertion	20534489
nsv428137	CNV	Loss	18775914

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602822 OMIM disorders: --

UniProtKB/Swiss-Prot: H4_HUMAN, P62805

Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell

NHL). Translocation t(3;6)(q27;p21), with BCL6

Selected diseases for HIST1H4A (see all 21):
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cockayne syndrome kaposi's sarcoma non-hodgkin lymphoma hodgkin's lymphoma

hiv-1 breast and colorectal cancer hepatitis c virus systemic lupus erythematosus

sarcoma hepatitis c lupus erythematosus tonsillitis

hepatocellular carcinoma thyroiditis hepatitis neuroblastoma

colorectal cancer breast cancer cerebritis prostate cancer

1 disease from the University of Copenhagen DISEASES database for HIST1H4A:

Cancer

HIST1H4A for disorders About GeneDecksing

Export disorders for HIST1H4A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HIST1H4A gene, integrated from 10 sources (see all 176):
(articles sorted by number of sources associating them with HIST1H4A)

Utopia: connect your pdf to the dynamic
world of online information

The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F.... Maltais L.J. (Genomics 2002)
Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)^{1, 2, 3} Albig W.... Doenecke D. (Genomics 1997)
BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)^{1, 2} Yan Q....Shipp M.A. (Mol. Cell 2009)
SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. (PubMed id 15964846)^{1, 2} Yin Y.... Zhu G. (J. Biol. Chem. 2005)
Histone sumoylation is associated with transcriptional repression. (PubMed id 14578449)^{1, 2} Shiio Y. and Eisenman R.N. (Proc. Natl. Acad. Sci. U.S.A. 2003)
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. (PubMed id 11387442)^{1, 2} Wang H.... Zhang Y. (Science 2001)
The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)^{1, 2} Albig W. and Doenecke D. (Hum. Genet. 1997)
Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PubMed id 3035717)^{1, 2} Pauli U.... Nick H. (Science 1987)
Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)¹ Vigodner M....Callaway M. (Hum. Reprod. 2013)
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)¹ Bett J.S....Hay R.T. (Biochem. J. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8359	HGNC: 4781	AceView: HIST1H4A	Ensembl:ENSG00000196176	euGenes: HUgn8359
ECgene: HIST1H4A	Kegg: 8359	H-InvDB: HIST1H4A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HIST1H4A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HIST1H4A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HIST1H4A gene:
Search GeneIP for patents involving HIST1H4A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Histone Cluster 1, H4a

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HIST1H4A (Gene Symbol)
Histone Cluster 1, H4a
H4FA
H4 Histone Family, Member A
Histone 1, H4a
Histone H4
H4/A
H4/B
H4/C
H4/D
H4/E
H4/G
H4/H
H4/I
H4/J
H4/K
H4/M
H4/N
H4/O
H4F2
H4FB
H4FC
H4FD
H4FE
H4FG
H4FH
H4FI
H4FJ
H4FK
H4FM
H4FN
H4FO
HIST2H4

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HIST1H4A Gene

Histone Cluster 1, H4a

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