Aliases for HIST1H3J Gene
Aliases for HIST1H3J Gene
- Histone Cluster 1 H3 Family Member J 2 3 5
- H3 Histone Family, Member J 2 3
- Histone Cluster 1, H3j 2 3
- Histone 1, H3j 2 3
- Histone H3/J 3 4
- H3FJ 3 4
- HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J 4
- Histone H3.1 3
- Histone H3/A 4
- Histone H3/B 4
- Histone H3/C 4
- Histone H3/D 4
- Histone H3/F 4
- Histone H3/H 4
External Ids for HIST1H3J Gene
- HGNC: 4774
- Entrez Gene: 8356
- Ensembl: ENSG00000197153
- OMIM: 602817
- UniProtKB: P68431
Previous HGNC Symbols for HIST1H3J Gene
- H3FJ
Previous GeneCards Identifiers for HIST1H3J Gene
- GC06M027916
- GC06M027966
- GC06M027862
- GC06M027665
- GC06M027920
- GC06M027941
- GC06M027963
- GC06M027986
- GC06M028004
- GC06M028013
- GC06M028034
- GC06M028056
- GC06M028077
Summaries for HIST1H3J Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H3J Gene
HIST1H3J (Histone Cluster 1 H3 Family Member J) is a Protein Coding gene. Diseases associated with HIST1H3J include Diffuse Intrinsic Pontine Glioma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and histone binding. An important paralog of this gene is HIST1H3C.
UniProtKB/Swiss-Prot for HIST1H3J Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for HIST1H3J Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H3J Gene
Genomics for HIST1H3J Gene
GeneHancer (GH) Regulatory Elements for HIST1H3J Gene
Promoters and enhancers for HIST1H3J Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HIST1H3J on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HIST1H3J Gene
Genomic Locations for HIST1H3J Gene
- chr6:27,890,315-27,893,106
- (GRCh38/hg38)
- Size:
- 2,792 bases
- Orientation:
- Minus strand
- chr6:27,858,093-27,860,884
- (GRCh37/hg19)
Genomic View for HIST1H3J Gene
Genes around HIST1H3J on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
HIST1H3J Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H3J Gene
Proteins for HIST1H3J Gene
-
Protein details for HIST1H3J Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68431-H31_HUMAN
- Recommended name:
- Histone H3.1
- Protein Accession:
- P68431
- A0PJT7
- A5PLR1
- P02295
- P02296
- P16106
- Q6ISV8
- Q6NWP8
- Q6NWP9
- Q6NXU4
- Q71DJ3
- Q93081
Protein attributes for HIST1H3J Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15404 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- Miscellaneous:
-
- This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
Protein Expression for HIST1H3J Gene
Post-translational modifications for HIST1H3J Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
- Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (PubMed:22483618).
- Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
- Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
- Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- Ubiquitination at isoforms=116
Other Protein References for HIST1H3J Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
-
OriGene Purified Proteins for HIST1H3J
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H3J
- Origene Custom Protein Services for HIST1H3J
- Search GeneTex for Proteins for HIST1H3J
-
Abcam proteins for HIST1H3J
Assay Products
No data available for DME Specific Peptides for HIST1H3J Gene
Domains & Families for HIST1H3J Gene
Gene Families for HIST1H3J Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HIST1H3J Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H3J Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P68431- Family:
-
- Belongs to the histone H3 family.
Function for HIST1H3J Gene
Molecular function for HIST1H3J Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for HIST1H3J Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10949293 |
| GO:0031492 | nucleosomal DNA binding | IBA | -- |
| GO:0042393 | histone binding | IPI | -- |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for HIST1H3J Gene
- GenomeRNAi human phenotypes for HIST1H3J:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST1H3J
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3J gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3J gene
- Search ViGene Biosciences for HIST1H3J
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H3J
- genomics-online: gRNA clones - Search results for 76 available HIST1H3J gene related products
- Overview of 76 available HIST1H3J gene related products
- Applied Biological Materials CRISPR for HIST1H3J
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3J
- GenScript: Design CRISPR guide RNA sequences for HIST1H3J
miRNA for HIST1H3J Gene
- miRTarBase miRNAs that target HIST1H3J
-
- hsa-mir-34a-5p (MIRT025221)
- hsa-mir-760 (MIRT378446)
- hsa-mir-6822-3p (MIRT378452)
- hsa-mir-5693 (MIRT511612)
- hsa-mir-8057 (MIRT511613)
- hsa-mir-6079 (MIRT511614)
- hsa-mir-671-5p (MIRT511615)
- hsa-mir-6828-5p (MIRT511616)
- hsa-mir-4766-5p (MIRT511617)
- hsa-mir-146a-3p (MIRT511618)
- hsa-mir-4538 (MIRT511619)
- hsa-mir-4453 (MIRT511620)
- hsa-mir-100-3p (MIRT511621)
- hsa-mir-1276 (MIRT511622)
miRNA Products
- Search ViGene Biosciences for HIST1H3J
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HIST1H3J
- Browse OriGene Inhibitory RNA Products For HIST1H3J
- genomics-online: shRNA clones - Search results for 76 available TEX14 gene related products
- Overview of 76 available TEX14 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3J gene
Clone Products
-
OriGene ORF clones in human for HIST1H3J
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HIST1H3J
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H3J
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for HIST1H3J
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HIST1H3J
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H3J gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3J gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3J gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H3J Gene
Localization for HIST1H3J Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H3J Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | -- |
| GO:0000786 | nucleosome | IDA,IBA | 21636898 |
| GO:0000788 | nuclear nucleosome | IDA | 20498094 |
| GO:0005576 | extracellular region | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H3J Gene
Pathways & Interactions for HIST1H3J Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | Cellular Senescence (REACTOME) | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Chromatin organization | ||
| 5 | Mitotic Prophase |
.57
|
|
Pathways by source for HIST1H3J Gene
1 BioSystems pathway for HIST1H3J Gene
54 Reactome pathways for HIST1H3J Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H3J Gene
8 Qiagen pathways for HIST1H3J Gene
Interacting Proteins for HIST1H3J Gene
Selected Interacting proteins:
P68431-H31_HUMAN
ENSP00000352252
for HIST1H3J Gene via
MINT
UniProtKB
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006325 | chromatin organization | TAS | -- |
| GO:0006334 | nucleosome assembly | IMP,IBA | 25615412 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0007596 | blood coagulation | TAS | -- |
No data available for SIGNOR curated interactions for HIST1H3J Gene
Transcripts for HIST1H3J Gene
mRNA/cDNA for HIST1H3J Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (8) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H3J Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H3J
- genomics-online: gRNA clones - Search results for 76 available HIST1H3J gene related products
- Overview of 76 available HIST1H3J gene related products
- Applied Biological Materials CRISPR for HIST1H3J
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3J
- GenScript: Design CRISPR guide RNA sequences for HIST1H3J
miRNA Products
- Search ViGene Biosciences for HIST1H3J
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HIST1H3J
- Browse OriGene Inhibitory RNA Products For HIST1H3J
- genomics-online: shRNA clones - Search results for 76 available TEX14 gene related products
- Overview of 76 available TEX14 gene related products