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HIST1H3J Gene

protein-coding GIFtS: 49
GCID: GC06M027941

Histone Cluster 1, H3j

(Previous names: H3 histone family, member J, histone 1, H3j)
(Previous symbol: H3FJ)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Histone Cluster 1, H3j¹ ²		H3FI³
H3FJ¹ ² ³ ⁵		H3FK³
H3 Histone Family, Member J¹ ²		H3FL³
Histone 1, H3j¹ ²		Histone H3/A³
Histone H3/J² ³		Histone H3/B³
H3/j²		Histone H3/C³
Histone H3.1²		Histone H3/D³
H3FA³		Histone H3/F³
H3FB³		Histone H3/H³
H3FC³		Histone H3/I³
H3FD³		Histone H3/K³
H3FF³		Histone H3/L³
H3FH³

External Ids:	HGNC: 4774¹	Entrez Gene: 8356²	Ensembl: ENSG00000197153⁷	OMIM: 602817⁵	UniProtKB: P68431³

Export aliases for HIST1H3J gene to outside databases

Previous GC identifers: GC06M027916 GC06M027966 GC06M027862 GC06M027665 GC06M027920

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H3J Gene:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in

eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which

approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts

with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.

This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA

tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster

on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H3J Gene:

HIST1H3J (histone cluster 1, H3j) is a protein-coding gene. An important paralog of this gene is HIST2H3C.

UniProtKB/Swiss-Prot: H31_HUMAN, P68431

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA

accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role

in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is

regulated via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling

Gene Wiki entry for HIST1H3J Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000006.11 NC_018917.2 NT_007592.16

Regulatory elements:

Regulatory transcription factor binding sites in the HIST1H3J gene promoter:
TBP Pax-5 AML1a Lmo2 MIF-1 Evi-1 HOXA5 FOXO4 ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H3J promoter sequence

Search Chromatin IP Primers for HIST1H3J

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H3J

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.1

HIST1H3J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H3J gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M027941: view genomic region (about GC identifiers)

Start:	27,858,093 bp from pter	End:	27,860,884 bp from pter
Size:	2,792 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: H31_HUMAN, P68431 (See protein sequence)

Recommended Name: Histone H3.1

Size: 136 amino acids; 15404 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one

H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down

during the process of differentiation

Miscellaneous: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation

of Lys-10 (H3K9me2)

Selected PDB 3D structures from and Proteopedia for HIST1H3J (see all 74):

1CS9 (3D)

1CT6 (3D)

1Q3L (3D)

2B2T (3D)

2B2U (3D)

2B2V (3D)

Secondary accessions: A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3

Q93081

Explore the universe of human proteins at neXtProt for HIST1H3J: NX_P68431

Explore proteomics data for HIST1H3J at MOPED

Post-translational modifications:

Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9

(H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).

Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the

surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability¹

Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription¹

Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at

Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is

linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is

present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while

it is absent on active promoters¹

Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at

Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated

with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me)

and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1

proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3

and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at

'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.

Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for

DNA replication¹

Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.

Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression

during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important

during interphase because it enables the transcription of genes following external stimulation, like mitogens,

stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.

Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)

but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation

of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an

essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK

isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)

by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5

(H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early

anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic

transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at

Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by

modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5

(HP1 alpha) from chromatin¹

Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By

similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken

the interaction between histones and DNA and facilitate DNA accessibility to repair proteins¹

Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only

takes place on H3K4me3 and results in gene repression (PubMed:22483618)¹

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic

cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks

active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with

post-meiotically activated genes on autosomes¹

Ubiquitination² at Lys19, Lys24, Lys57, Lys65, Lys80, Lys116, Lys123

Modification sites at PhosphoSitePlus

See HIST1H3J Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003526.1

ENSEMBL proteins:

ENSP00000352252

Reactome Protein details: P68431

HIST1H3J Human Recombinant Protein Products:

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	Search antibodies-online for peptides for HIST1H3J

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

HIST: Histones / Replication-dependent

3 InterPro protein domains:

IPR000164 Histone_H3

IPR009072 Histone-fold

IPR007125 Histone_core_D

Graphical View of Domain Structure for InterPro Entry P68431

ProtoNet protein and cluster: P68431

UniProtKB/Swiss-Prot: H31_HUMAN, P68431

Similarity: Belongs to the histone H3 family

Find genes that share domains with HIST1H3J About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: H31_HUMAN, P68431

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA

accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role

in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is

regulated via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0005515	protein binding	--	--
GO:0046982	protein heterodimerization activity	--	--

Find genes that share ontologies with HIST1H3J About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for HIST1H3J

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In Situ Assay
Products:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

H31_HUMAN, P68431: Nucleus. Chromosome

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
extracellular	4
cytosol	2

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	--	--
GO:0005576	extracellular region	--	--
GO:0005654	nucleoplasm	--	--

Find genes that share ontologies with HIST1H3J About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for HIST1H3J About (see all 16)

See pathways by source

Powered
by

SuperPath

Selected contained pathways About (see all per SuperPath)

RNA Polymerase I Promoter Opening

RNA Polymerase I Transcription	0.78	Mitotic Prophase	0.56
RNA Polymerase I Chain Elongation	0.78	Systemic lupus erythematosus	0.40
RNA Polymerase I Promoter Clearance	0.78	Chromatin organization	0.34
RNA Polymerase I Promoter Opening	0.78	Chromatin modifying enzymes	0.34

Cellular Senescence

	Cellular Senescence	0.81			Oxidative Stress Induced Senescence	0.64
	Cellular responses to stress	0.81			Senescence-Associated Secretory Phenotype (SASP)	0.57

Cell Cycle, Mitotic

	Cell Cycle, Mitotic	0.90			M Phase	0.62
	Cell Cycle	0.90

Meiosis

Meiosis

0.74

Meiotic Recombination

0.74

UVA-Induced MAPK Signaling

UVB-Induced MAPK Signaling

0.38

UVA-Induced MAPK Signaling

0.38

Find genes that share SuperPaths with HIST1H3J About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H3J (see all 8)

	Nuclear Receptor Activation by Vitamin-A
	PKA Signaling
	UVB-Induced MAPK Signaling
	Interferon Pathway
	Crosstalk Between CARM1 and ESRs

Selected Reactome Pathways for HIST1H3J (see all 13)

	HATs acetylate histones
	NoRC negatively regulates rRNA expression
	Meiotic recombination
	formation of the beta-catenin:TCF transactivating complex
	Oxidative Stress Induced Senescence

3 Kegg Pathways (Kegg details for HIST1H3J):

	Alcoholism
	Transcriptional misregulation in cancer
	Systemic lupus erythematosus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for HIST1H3J
Interactions:

Search GeneGlobe Interaction Network for HIST1H3J

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for HIST1H3J (P68431^{1, 2, 3} ENSP00000352252⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 228)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC101	Q96ES7¹^,²^,³	EBI-79722,EBI-743117 MINT-8208820 MINT-8208994 MINT-8209533 MINT-8209481 MINT-8208878 MINT-8208960 MINT-8209125 MINT-8209567 MINT-8208901 MINT-8209070 MINT-8209550 MINT-8208976 MINT-8209091 MINT-8209584 MINT-8209261 MINT-8209449 MINT-8209516 MINT-8208834 MINT-8208806 MINT-8208846 MINT-8208860 MINT-8209427 MINT-8209498 MINT-8209465 MINT-8209145 MINT-8208780 I2D: score=1
AIRE	O43918¹^,²^,³	EBI-79722,EBI-1753081 MINT-6542493 MINT-6542602 MINT-6542217 MINT-6542176 MINT-6542437 MINT-6542623 MINT-6542513 MINT-6542121 MINT-6542585 MINT-6542551 MINT-6542098 MINT-6542155 MINT-6542420 MINT-6542202 MINT-6542385 MINT-6542408 MINT-6542567 MINT-6542476 MINT-6542533 MINT-6542137 I2D: score=3
CBX5	P45973¹^,²^,³	EBI-79722,EBI-78219 MINT-2830662 MINT-8087423 MINT-8087281 MINT-7221095 MINT-8087437 MINT-2830965 MINT-2830941 MINT-8087264 MINT-7221313 MINT-8087449 I2D: score=3
CBX1	P83916¹^,²^,³	EBI-79722,EBI-78129 MINT-2830869 MINT-2829009 MINT-2830731 MINT-8087351 MINT-2830755 MINT-8087334 MINT-2829033 MINT-2828976 MINT-2829858 I2D: score=8
WDR5	P61964¹^,²^,³	EBI-79722,EBI-540834 MINT-3319451 MINT-3293300 MINT-3293375 MINT-3319546 MINT-3293337 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319477 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	--	--
GO:0007596	blood coagulation	--	--
GO:0060968	regulation of gene silencing	--	--

Find genes that share ontologies with HIST1H3J About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for HIST1H3J (H31)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for HIST1H3J gene:

NM_003535.2

Unigene Cluster for HIST1H3J:

Histone cluster 1, H3j

Hs.484990

Unigene Representative Sequence: AL522145

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000479986 ENST00000359303(uc003nka.3)

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1 DOTS entry:

DT.91669233

8 AceView cDNA sequences:

NM_003535 CR612219 BX368993 BX371361 AL522145 AI970475 BF511773 AL522144

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HIST1H3J expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

HIST1H3J expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


NULL (Uncategorized)
Mesenchymal Progenitor Cells - Passage 2

HIST1H3J Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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HIST1H3J Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.484990

Custom PCR Arrays for HIST1H3J

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H3J gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hist1h3g¹	histone cluster 1, H3g	85.05(n) 100(a)		97908 NM_145073.2 NP_659539.1
lizard (Anolis carolinensis)	Reptilia	--	Histone H3	96(a)	1 → many	GL343279.1(552493-552912)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC101732029¹	neurofilament heavy polypeptide-like	81.13(n) 99.26(a)		101732029 XM_004915717.1 XP_004915774.1
zebrafish (Danio rerio)	Actinopterygii	LOC100004914¹	histone H3-like centromeric protein cpar-1-like	80.74(n) 99.26(a)		100004914 XM_005172166.1 XP_005172223.1
fruit fly (Drosophila melanogaster)	Insecta	His3:CG33830¹	His3:CG33830	79.9(n) 99.26(a)		3771792 NM_001032157.1 NP_001027328.1
worm (Caenorhabditis elegans)	Secernentea	his-2¹	his-2	77.21(n) 97.06(a)		180074 NM_074632.3 NP_507033.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G40030¹	AT4G40030	74.02(n) 96.32(a)		830164 NM_001085047.1 NP_001078516.1
rice (Oryza sativa)	Liliopsida	Os06g0130900¹	Os06g0130900	80.88(n) 96.32(a)		4340006 NM_001063228.1 NP_001056693.1

ENSEMBL Gene Tree for HIST1H3J (if available)
TreeFam Gene Tree for HIST1H3J (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for HIST1H3J gene

HIST2H3C² H3F3C² HIST1H3A² HIST2H3PS2² HIST1H3B² HIST1H3E² HIST2H3D² HIST1H3D²

HIST1H3H² HIST3H3² H3F3A² HIST1H3F² HIST1H3I² HIST1H3G² HIST1H3C² H3F3B²

HIST2H3A²

9 SIMAP similar genes for HIST1H3J using alignment to 1 protein entry: H31_HUMAN:

HIST3H3 H3F3B H3F3A HIST2H3A HIST2H3C HIST2H3D

HIST2H3PS2 H3F3C CENPA

Find genes that share paralogs with HIST1H3J About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74982211^1,2	C	--	27857748(+)	`CAGTGC/ACCGTT`	1	--	ds500¹		2		CSA WA	120
rs115106149^1,2	C,F	--	27857831(+)	`AAAGGA/GCAGCA`	1	--	ds500¹		1		WA	118
rs115908172^1,2	C,F	--	27857925(+)	`CCCTTG/ATGAGA`	1	--	ds500¹		1		WA	118
rs181627761^1,2		--	27857967(+)	`CTTAGA/GAGACA`	1	--	ds500¹		0	--	--	--	--
rs148510300^1,2		--	27857984(+)	`ACTGCA/CAGGAA`	1	--	ds500¹		0	--	--	--	--
rs73386651^1,2	C,F	--	27858040(+)	`TTTAAA/GGTTGA`	1	--	ds500¹		3		WA NA	240
rs184135815^1,2		--	27858046(+)	`GTTGAC/TTTAAG`	1	--	ds500¹		0	--	--	--	--
rs202049846^1,2	C	--	27858146(+)	`CCCAAG/AATAGA`	1	--	ut3¹		1		EU	1323
rs201216167^1,2		--	27858151(+)	`GATAGA/GGCAGG`	1	--	ut3¹		0	--	--	--	--
rs200973^1,2	C,F,A,H	--	27858421(+)	`ATCTCA/GCGCAA`	2	R	syn¹ ese³		24		MN EA NS NA WA CSA EU	9116

HapMap Linkage Disequilibrium report for HIST1H3J (27858093 - 27860884 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for HIST1H3J: About this table

Variant ID	Type	Subtype	PubMed ID
nsv883512	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 602817 OMIM disorders: --

Find genes that share disorders with HIST1H3J About GenesLikeMe

Export disorders for HIST1H3J gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HIST1H3J gene, integrated from 10 sources (see all 58):
(articles sorted by number of sources associating them with HIST1H3J)

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The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F.... Maltais L.J. (Genomics 2002)
The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)^{1, 2, 3} Albig W. and Doenecke D. (Hum. Genet. 1997)
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. (PubMed id 23415232)² Tropberger P....Schneider R. (Cell 2013)
Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. (PubMed id 22387026)² Yu Y.... Grunstein M. (Mol. Cell 2012)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. (PubMed id 22483618)² Herranz N.... Peiro S. (Mol. Cell 2012)
Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)¹ Zhao J....Yang P. (J Proteomics 2011)
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)² Tan M.... Zhao Y. (Cell 2011)
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)¹ Altun M....Kessler B.M. (amp 2011)
Structural basis for human PHF2 Jumonji domain interaction with metal ions. (PubMed id 21167174)¹ Horton J.R.... Cheng X. (J. Mol. Biol. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8356	HGNC: 4774	AceView: HIST1H3J	Ensembl:ENSG00000197153	euGenes: HUgn8356
ECgene: HIST1H3J	Kegg: 8356	H-InvDB: HIST1H3J

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HIST1H3J	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HIST1H3J gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HIST1H3J gene:
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HIST1H3J Gene

Histone Cluster 1, H3j

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HIST1H3J (Gene Symbol)
Histone Cluster 1, H3j
H3FJ
H3 Histone Family, Member J
Histone 1, H3j
Histone H3/J
H3/j
Histone H3.1
H3FA
H3FB
H3FC
H3FD
H3FF
H3FH
H3FI
H3FK
H3FL
Histone H3/A
Histone H3/B
Histone H3/C
Histone H3/D
Histone H3/F
Histone H3/H
Histone H3/I
Histone H3/K
Histone H3/L

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HIST1H3J Gene

Histone Cluster 1, H3j

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