Aliases for HIST1H3H Gene
Aliases for HIST1H3H Gene
- Histone Cluster 1 H3 Family Member H 2 3 5
- H3 Histone Family, Member K 2 3
- Histone Cluster 1, H3h 2 3
- Histone 1, H3h 2 3
- Histone H3/K 3 4
- H3FK 3 4
- HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J 4
- Histone H3.1 3
- Histone H3/A 4
- Histone H3/B 4
- Histone H3/C 4
- Histone H3/D 4
- Histone H3/F 4
- Histone H3/H 4
- Histone H3/I 4
External Ids for HIST1H3H Gene
- HGNC: 4775
- Entrez Gene: 8357
- Ensembl: ENSG00000278828
- OMIM: 602818
- UniProtKB: P68431
Previous HGNC Symbols for HIST1H3H Gene
- H3FK
Previous GeneCards Identifiers for HIST1H3H Gene
- GC06P027836
- GC06P027885
- GC06P027884
- GC06P027777
- GC06P027587
Summaries for HIST1H3H Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H3H Gene
HIST1H3H (Histone Cluster 1 H3 Family Member H) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Meiosis. GO annotations related to this gene include protein heterodimerization activity and histone binding. An important paralog of this gene is HIST1H3B.
UniProtKB/Swiss-Prot for HIST1H3H Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H3H Gene
Genomics for HIST1H3H Gene
Regulatory Elements for HIST1H3H Gene
Enhancers for HIST1H3H Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H3H on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST1H3H Gene
- Chromosome:
- 6
- Start:
- 27,810,064 bp from pter
- End:
- 27,811,300 bp from pter
- Size:
- 1,237 bases
- Orientation:
- Plus strand
Genomic View for HIST1H3H Gene
Genes around HIST1H3H on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
HIST1H3H Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H3H Gene
Proteins for HIST1H3H Gene
-
Protein details for HIST1H3H Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68431-H31_HUMAN
- Recommended name:
- Histone H3.1
- Protein Accession:
- P68431
- A0PJT7
- A5PLR1
- P02295
- P02296
- P16106
- Q6ISV8
- Q6NWP8
- Q6NWP9
- Q6NXU4
- Q71DJ3
- Q93081
Protein attributes for HIST1H3H Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15404 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- Miscellaneous:
-
- This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
Protein Expression for HIST1H3H Gene
Post-translational modifications for HIST1H3H Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (PubMed:22483618).
- Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
- Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
- Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- Ubiquitination at posLast=116116
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H3H Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H3H
- Search GeneTex for Antibodies for HIST1H3H
Protein Products
-
OriGene Purified Proteins for HIST1H3H
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H3H
- Origene Custom Protein Services for HIST1H3H
- Search GeneTex for Proteins for HIST1H3H
Assay Products
No data available for DME Specific Peptides for HIST1H3H Gene
Domains & Families for HIST1H3H Gene
Gene Families for HIST1H3H Gene
- HGNC:
Protein Domains for HIST1H3H Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P68431- Family:
-
- Belongs to the histone H3 family.
No data available for Suggested Antigen Peptide Sequences for HIST1H3H Gene
Function for HIST1H3H Gene
Molecular function for HIST1H3H Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10949293 |
| GO:0042393 | histone binding | IPI | 20498094 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H3H Gene
- GenomeRNAi human phenotypes for HIST1H3H:
-
- Decreased shRNA abundance (Z-score < -2)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3H gene
- Search ViGene Biosciences for HIST1H3H
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H3H
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3H
- GenScript: Design CRISPR guide RNA sequences for HIST1H3H
miRNA for HIST1H3H Gene
- miRTarBase miRNAs that target HIST1H3H
-
- hsa-mir-34a-5p (MIRT025410)
- hsa-mir-497-5p (MIRT041185)
- hsa-mir-193b-3p (MIRT041435)
- hsa-mir-484 (MIRT042117)
- hsa-mir-378a-3p (MIRT043885)
- hsa-mir-320a (MIRT044702)
- hsa-mir-34a-3p (MIRT100143)
- hsa-mir-146a-3p (MIRT100144)
- hsa-mir-379-3p (MIRT100145)
- hsa-mir-380-3p (MIRT100146)
- hsa-mir-411-3p (MIRT100147)
- hsa-mir-760 (MIRT100148)
- hsa-mir-1225-5p (MIRT100149)
- hsa-mir-1229-5p (MIRT100150)
- hsa-mir-1276 (MIRT100151)
- hsa-mir-4495 (MIRT100156)
- hsa-mir-8057 (MIRT100159)
- hsa-mir-5693 (MIRT511623)
- hsa-mir-6759-5p (MIRT511624)
- hsa-mir-6793-5p (MIRT511625)
- hsa-mir-6748-5p (MIRT511626)
- hsa-mir-4483 (MIRT511627)
- hsa-mir-1293 (MIRT511628)
- hsa-mir-6766-5p (MIRT511629)
- hsa-mir-6756-5p (MIRT511630)
- hsa-mir-6745 (MIRT511631)
- hsa-mir-363-5p (MIRT511632)
- hsa-mir-503-3p (MIRT511633)
- hsa-mir-6822-3p (MIRT511634)
- hsa-mir-4766-5p (MIRT511635)
- hsa-mir-299-3p (MIRT511636)
miRNA Products
- Search ViGene Biosciences for HIST1H3H
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for HIST1H3H
- Browse OriGene Inhibitory RNA Products For HIST1H3H
- Search ViGene Biosciences for HIST1H3H
Clone Products
-
OriGene ORF clones in human for HIST1H3H
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H3H
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H3H gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3H gene
- Search ViGene Biosciences for HIST1H3H
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H3H Gene
Localization for HIST1H3H Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H3H Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | IDA | 21636898 |
| GO:0000788 | nuclear nucleosome | IDA | 20498094 |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST1H3H Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | Cellular Senescence | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Chromatin organization | ||
| 5 | Mitotic Prophase |
.57
|
|
Pathways by source for HIST1H3H Gene
1 BioSystems pathway for HIST1H3H Gene
54 Reactome pathways for HIST1H3H Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H3H Gene
8 Qiagen pathways for HIST1H3H Gene
Interacting Proteins for HIST1H3H Gene
Selected Interacting proteins:
P68431-H31_HUMAN
ENSP00000358160
for HIST1H3H Gene via
MINT
UniProtKB
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006325 | chromatin organization | TAS | -- |
| GO:0006334 | nucleosome assembly | IMP | 25615412 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0007596 | blood coagulation | TAS | -- |
No data available for SIGNOR curated interactions for HIST1H3H Gene
Transcripts for HIST1H3H Gene
mRNA/cDNA for HIST1H3H Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H3H Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H3H
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3H
- GenScript: Design CRISPR guide RNA sequences for HIST1H3H
miRNA Products
- Search ViGene Biosciences for HIST1H3H
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for HIST1H3H
- Browse OriGene Inhibitory RNA Products For HIST1H3H
- Search ViGene Biosciences for HIST1H3H
Clone Products
-
OriGene ORF clones in human for HIST1H3H
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H3H Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for HIST1H3H Gene
This gene is overexpressed in Whole Blood (x18.8).
This gene is overexpressed in Heart (41.5), Urine (13.4), and Cervix (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H3H Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIST1H3H Gene:
HIST1H3HSOURCE GeneReport for Unigene cluster for HIST1H3H Gene:
Hs.591778Evidence on tissue expression from TISSUES for HIST1H3H Gene
- Nervous system(4.5)
- Stomach(4.4)
- Spleen(4.3)
- Blood(4.2)
- Intestine(2.8)
- Bone marrow(2)
- Gall bladder(2)
- Heart(2)
- Kidney(2)
- Lung(2)
- Muscle(2)
- Pancreas(2)
- Skin(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for HIST1H3H
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H3H Gene
Orthologs for HIST1H3H Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC504599 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC483167 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h3b 34 16 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC462493 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC684841 34 |
|
||
| chicken (Gallus gallus) |
Aves | LOC100858681 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100494884 34 |
|
||
| Str.3150 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | h3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:173552 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His3:CG33854 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CSE4 37 |
|
|
- Species where no ortholog for HIST1H3H was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST1H3H Gene
Paralogs for HIST1H3H Gene
(9) SIMAP similar genes for HIST1H3H Gene using alignment to 1 proteins:
Variants for HIST1H3H Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000537687 | -- | 27,810,046(+) | TCTTT(C/T)TCCTG | upstream-variant-2KB | |
| rs1000937977 | -- | 27,810,606(+) | GATAG(A/G)GCCCA | downstream-variant-500B | |
| rs1003461925 | -- | 27,808,757(+) | TCAGT(C/T)TTCGG | downstream-variant-500B, upstream-variant-2KB | |
| rs1004838126 | -- | 27,810,593(+) | TTTGC(C/G)TGTAG | downstream-variant-500B | |
| rs1005508169 | -- | 27,808,238(+) | AGGCA(A/G)AGCTC | upstream-variant-2KB, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3890803 | CNV | loss | 25118596 |
| nsv1017057 | CNV | gain | 25217958 |
| nsv830618 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.22;
4.91% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H3H Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H3H
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H3H Gene
Disorders for HIST1H3H Gene
Relevant External Links for HIST1H3H
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H3H
No disorders were found for HIST1H3H Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H3H Gene
Publications for HIST1H3H Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4 64
- Expression patterns and post-translational modifications associated with mammalian histone H3 variants. (PMID: 16267050) Hake S.B. … Hunt D.F. (J. Biol. Chem. 2006) 3 4 64
- Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PMID: 16246723) Macdonald N. … Mahadevan L.C. (Mol. Cell 2005) 3 4 64
- Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. (PMID: 11242053) Lachner M. … Jenuwein T. (Nature 2001) 3 4 64
Products for HIST1H3H Gene
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- Browse OriGene Antibodies
- Custom Antibody Services
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- OriGene Purified Proteins for HIST1H3H
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H3H
- Origene Custom Protein Services for HIST1H3H
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H3H
- Browse OriGene Inhibitory RNA Products For HIST1H3H
- OriGene qPCR primer pairs for HIST1H3H
- OriGene CRISPR knockouts for HIST1H3H
- OriGene ORF clones in human for HIST1H3H
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIST1H3H
- GenScript: Next-day shipping cDNA ORF clone for HIST1H3H in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HIST1H3H
- GenScript Custom Assay Services for HIST1H3H
- GenScript Custom overexpressing Cell Line Services for HIST1H3H
- GenScript: Design CRISPR guide RNA sequences for HIST1H3H
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals proteins and lysates for HIST1H3H
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H3H gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3H gene
- Search ViGene Biosciences for HIST1H3H
- Search Santa Cruz Biotechnology (SCBT) for HIST1H3H Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST1H3H siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3H
- Horizon Cell Lines for HIST1H3H
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST1H3H
- VectorBuilder custom plasmid, inducible vectors for HIST1H3H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H3H
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H3H Gene
- (1) GeneCards
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- (40) Pseudogene
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- (74) Cloud-Clone Corp.
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