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HIST1H3H Gene

protein-coding   GIFtS: 51
GCID: GC06P027777

Histone Cluster 1, H3h

(Previous names: H3 histone family, member K, histone 1, H3h)
(Previous symbol: H3FK)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H3h1 2     H3FH3
H3FK1 2 3 5     H3FI3
H3 Histone Family, Member K1 2     H3FJ3
Histone 1, H3h1 2     H3FL3
Histone H3/K2 3     Histone H3/A3
H3/k2     Histone H3/B3
H3F1K2     Histone H3/C3
Histone H3.12     Histone H3/D3
H3FA3     Histone H3/F3
H3FB3     Histone H3/H3
H3FC3     Histone H3/I3
H3FD3     Histone H3/J3
H3FF3     Histone H3/L3

External Ids:    HGNC: 47751   Entrez Gene: 83572   Ensembl: ENSG000002038137   OMIM: 6028185   UniProtKB: P684313   

Export aliases for HIST1H3H gene to outside databases

Previous GC identifers: GC06P027836 GC06P027885 GC06P027884 GC06P027587


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H3H Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H3H Gene:
HIST1H3H (histone cluster 1, H3h) is a protein-coding gene. Diseases associated with HIST1H3H include systemic lupus erythematosus, and lupus erythematosus. An important paralog of this gene is HIST2H3C.

UniProtKB/Swiss-Prot: H31_HUMAN, P68431
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H3H Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H3H gene promoter:
         NF-YA   AP-4   Egr-4   NF-YB   CBF-A   CBF-B   FOXO4   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H3H promoter sequence
   Search Chromatin IP Primers for HIST1H3H

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H3H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H3H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H3H gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027777:  view genomic region     (about GC identifiers)

Start:
27,777,842 bp from pter      End:
27,778,314 bp from pter
Size:
473 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H31_HUMAN, P68431 (See protein sequence)
Recommended Name: Histone H3.1  
Size: 136 amino acids; 15404 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down
during the process of differentiation
Miscellaneous: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation
of Lys-10 (H3K9me2)
Selected PDB 3D structures from and Proteopedia for HIST1H3H (see all 74):
1CS9 (3D)        1CT6 (3D)        1Q3L (3D)        2B2T (3D)        2B2U (3D)        2B2V (3D)    
Secondary accessions: A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3
Q93081

Explore the universe of human proteins at neXtProt for HIST1H3H: NX_P68431

Explore proteomics data for HIST1H3H at MOPED

Post-translational modifications: 

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).
    Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the
    surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at
    Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is
    linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is
    present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while
    it is absent on active promoters1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated
    with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me)
    and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1
    proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3
    and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at
    'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
    Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for
    DNA replication1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression
    during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important
    during interphase because it enables the transcription of genes following external stimulation, like mitogens,
    stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.
    Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)
    but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation
    of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an
    essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK
    isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)
    by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5
    (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early
    anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic
    transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at
    Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by
    modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5
    (HP1 alpha) from chromatin1
  • Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By
    similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken
    the interaction between histones and DNA and facilitate DNA accessibility to repair proteins1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only
    takes place on H3K4me3 and results in gene repression (PubMed:22483618)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST1H3H Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003527.1  
    ENSEMBL proteins: 
     ENSP00000358160  
    Reactome Protein details: P68431

    HIST1H3H Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HIST1H3H

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    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H3H
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    Search ThermoFisher Antibodies for HIST1H3H
    Search LSBio for Antibodies for HIST1H3H

    HIST1H3H Assay Products:

    EMD Millipore Kits and Assays for the Analysis of HIST1H3H
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    Cloud-Clone Corp. ELISAs for HIST1H3H
    Cloud-Clone Corp. CLIAs for HIST1H3H


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P68431

    ProtoNet protein and cluster: P68431

    UniProtKB/Swiss-Prot: H31_HUMAN, P68431
    Similarity: Belongs to the histone H3 family


    HIST1H3H for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H31_HUMAN, P68431
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H3H for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H3H
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H3H

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H3H
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H3H

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST1H3H:
    hsa-mir-320a (MIRT044702), hsa-mir-484 (MIRT042117), hsa-mir-34a-5p (MIRT025410), hsa-mir-193b-3p (MIRT041435), hsa-mir-497-5p (MIRT041185), hsa-mir-378a-3p (MIRT043885)

    Block miRNA regulation of human, mouse, rat HIST1H3H using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H3H:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HIST1H3H (NM_003536)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H3H


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H31_HUMAN, P68431: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005654nucleoplasm ----

    HIST1H3H for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H3H About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    2Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74
    5UVA-Induced MAPK Signaling
    UVB-Induced MAPK Signaling0.38
    UVA-Induced MAPK Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H3H (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    Selected Reactome Pathways for HIST1H3H (see all 13)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    Meiotic recombination
    formation of the beta-catenin:TCF transactivating complex
    Oxidative Stress Induced Senescence


    3 Kegg Pathways  (Kegg details for HIST1H3H):
        Alcoholism
    Transcriptional misregulation in cancer
    Systemic lupus erythematosus


    HIST1H3H for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H3H
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H3H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H3H (P684311, 2, 3 ENSP000003581604) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC101Q96ES71, 2, 3EBI-79722,EBI-743117 MINT-8208820 MINT-8208994 MINT-8209533 MINT-8209481 MINT-8208878 MINT-8208960 MINT-8209125 MINT-8209567 MINT-8208901 MINT-8209070 MINT-8209550 MINT-8208976 MINT-8209091 MINT-8209584 MINT-8209261 MINT-8209449 MINT-8209516 MINT-8208834 MINT-8208806 MINT-8208846 MINT-8208860 MINT-8209427 MINT-8209498 MINT-8209465 MINT-8209145 MINT-8208780 I2D: score=1 
    AIREO439181, 2, 3EBI-79722,EBI-1753081 MINT-6542493 MINT-6542602 MINT-6542217 MINT-6542176 MINT-6542437 MINT-6542623 MINT-6542513 MINT-6542121 MINT-6542585 MINT-6542551 MINT-6542098 MINT-6542155 MINT-6542420 MINT-6542202 MINT-6542385 MINT-6542408 MINT-6542567 MINT-6542476 MINT-6542533 MINT-6542137 I2D: score=3 
    CBX5P459731, 2, 3EBI-79722,EBI-78219 MINT-2830662 MINT-8087423 MINT-8087281 MINT-7221095 MINT-8087437 MINT-2830965 MINT-2830941 MINT-8087264 MINT-7221313 MINT-8087449 I2D: score=3 
    WDR5P619641, 2, 3EBI-79722,EBI-540834 MINT-3319451 MINT-3293300 MINT-3293375 MINT-3319546 MINT-3293337 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319477 I2D: score=2 
    HIST1H4HP628052, 3, ENSP000002893524MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----
    GO:0007596blood coagulation ----
    GO:0060968regulation of gene silencing ----

    HIST1H3H for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H3H (H31)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H3H gene: 
    NM_003536.2  

    Unigene Cluster for HIST1H3H:

    Histone cluster 1, H3h
    Hs.591778  [show with all ESTs]
    Unigene Representative Sequence: BQ072669
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369163(uc003njm.3)
    miRNA
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    Additional mRNA sequence: 

    AK311991.1 BC096128.3 BC096129.3 BC096130.3 BC143046.1 BC148243.1 BC148250.1 

    2 DOTS entries:

    DT.436317  DT.92435974 

    1 AceView cDNA sequence:

    BU659003 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H3H expression in normal human tissues (normalized intensities)      HIST1H3H embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H3H Expression
    About this image


    HIST1H3H expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Colon (Gastrointestinal Tract)
    HIST1H3H Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H3H Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591778
        Custom PCR Arrays for HIST1H3H
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H3H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H3H gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h3h5
    Hist1h3b1
    histone cluster 1, H3h5
    histone cluster 1, H3b1
    88.24(n)1
    99.26(a)1
      13 (7.94 cM)5
    3191501  NM_178203.11  NP_835510.11 
     217176595 
    chicken
    (Gallus gallus)
    Aves LOC1008586811 histone H3.2-like 87.99(n)
    99.26(a)
      100858681  XM_003640374.2  XP_003640422.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H3
    96(a)
    1 → many
    GL343279.1(552493-552912)
    African clawed frog
    (Xenopus laevis)
    Amphibia h32 histone H3 85.71(n)    AJ556872.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1735521 zgc:173552 82.35(n)
    99.26(a)
      794406  XM_005163195.1  XP_005163252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His3:CG338541 His3:CG33854 82.11(n)
    99.26(a)
      3772191  NM_001032197.1  NP_001027368.1 
    soybean
    (Glycine max)
    eudicotyledons 467757082   -- 80.33(n)  


    ENSEMBL Gene Tree for HIST1H3H (if available)
    TreeFam Gene Tree for HIST1H3H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H3H gene
    HIST2H3C2  H3F3C2  HIST1H3A2  HIST2H3PS22  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST2H3D2  
    HIST1H3D2  HIST3H32  H3F3A2  HIST1H3F2  HIST1H3I2  HIST1H3G2  HIST1H3C2  H3F3B2  
    HIST2H3A2  
    9 SIMAP similar genes for HIST1H3H using alignment to 1 protein entry:     H31_HUMAN:
    HIST3H3    H3F3B    H3F3A    HIST2H3A    HIST2H3C    HIST2H3D
    HIST2H3PS2    H3F3C    CENPA

    HIST1H3H for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H3H (see all 35)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1435540181,2
    C--27777805(+) AAATAA/TGCGGC 1 -- us2k10--------
    rs1932853281,2
    C--27777827(+) TTCTCC/TTGAAG 1 -- us2k10--------
    rs2007964481,2
    C--27777942(+) GCGCTC/GCGGCC 2 P A mis11Minor allele frequency- G:0.00EU 1323
    rs2001125131,2
    C--27777956(-) TTGACA/CCCGCC 2 G syn10--------
    rs2018731911,2
    --27778037(+) CTGCTC/GATCAG 2 L syn10--------
    rs1398197741,2
    C,F--27778094(+) AAGACC/AGACTT 2 /T syn12Minor allele frequency- A:0.00NA EU 5873
    rs20218351,2
    C,F,O,A,H--27778097(+) ACCGAC/TTTGCG 2 D syn130Minor allele frequency- T:0.06MN NA NS EA WA EU 9045
    rs1850765991,2
    --27778112(+) CAGAGC/TTCCGC 2 S syn10--------
    rs1474446831,2
    C--27778118(+) TCCGCA/C/GGTGAT 3 A syn11NA 4550
    rs2009806561,2
    --27778122(+) CGGTGA/GTGGCG 2 M V mis10--------

    HapMap Linkage Disequilibrium report for HIST1H3H (27777842 - 27778314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H3H:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830618CNV Gain17160897
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H3H
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H3H

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602818    OMIM disorders: --

    4 diseases for HIST1H3H:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    hiv-1    breast cancer


    HIST1H3H for disorders           About GeneDecksing


    Export disorders for HIST1H3H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H3H gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with HIST1H3H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (Hum. Genet. 1997)
    3. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    4. Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. (PubMed id 23415232)2 Tropberger P....Schneider R. (Cell 2013)
    5. Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. (PubMed id 22387026)2 Yu Y.... Grunstein M. (Mol. Cell 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    8. Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. (PubMed id 22483618)2 Herranz N.... Peiro S. (Mol. Cell 2012)
    9. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (J Proteomics 2011)
    10. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8357 HGNC: 4775 AceView: HIST1H2AIandHIST1H3H Ensembl:ENSG00000203813 euGenes: HUgn8357
    ECgene: HIST1H3H Kegg: 8357 H-InvDB: HIST1H3H

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST1H3H Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H3H gene:
    Search GeneIP for patents involving HIST1H3H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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