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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H3D Gene

protein-coding   GIFtS: 55
GCID: GC06M026197

histone cluster 1, H3d

(Previous names: H3 histone family, member B, histone 1, H3d )
(Previous symbol: H3FB)
 Explore 3 diseases affiliated with
HIST1H3D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H3D    

Aliases
for HIST1H3D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H3d1 2     H3FJ3
H3FB1 2 3 5     H3FK3
H3/B1     H3FL3
H3 Histone Family, Member B1 2     Histone H3/A3
Histone 1, H3d1 2     Histone H3/C3
Histone H3/B2 3     Histone H3/D3
Histone H3.12     Histone H3/F3
H3FA3     Histone H3/H3
H3FC3     Histone H3/I3
H3FD3     Histone H3/J3
H3FF3     Histone H3/K3
H3FH3     Histone H3/L3
H3FI3     

External Ids:    HGNC: 47671   Entrez Gene: 83512   Ensembl: ENSG000001974097   OMIM: 6028115   UniProtKB: P684313   

Export aliases for HIST1H3D gene to outside databases

Previous GC identifers: GC06M026254 GC06M026306 GC06M026310 GC06M026312 GC06M026314 GC06M026140


Summaries
for HIST1H3D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H3D:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H31_HUMAN, P68431
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H3D


Genomic Views
for HIST1H3D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H3D gene promoter:
         AhR   AML1a   GCNF   GCNF-1   Olf-1   XBP-1   GCNF-2   Arnt   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H3D promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H3D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H3D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H3D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H3D gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026197:  view genomic region     (about GC identifiers)

Start:
 26,197,012 bp from pter      End:
 26,199,521 bp from pter
Size:
 2,510 bases      Orientation:
 minus strand

Proteins
for HIST1H3D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H31_HUMAN, P68431 (See protein sequence)
Recommended Name: Histone H3.1  
Size: 136 amino acids; 15404 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down during
the process of differentiation
Miscellaneous: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of
Lys-10 (H3K9me2)
6/55 PDB 3D structures from and Proteopedia for HIST1H3D (see all 55):
1CS9 (3D)        1CT6 (3D)        1Q3L (3D)        2B2T (3D)        2B2U (3D)        2B2V (3D)    
Secondary accessions: A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3 Q93081

Explore the universe of human proteins at neXtProt for HIST1H3D: NX_P68431

Post-translational modifications:

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    • (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9
    • (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to
    gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the
    3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on
    active promoters1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    • Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA
    double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28
    (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1,
    CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation
    at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at
    Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57
    (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation
    • at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and
    meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because
    it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV
    irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which
    is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from
    heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell
    transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon
    ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional
    activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at
    Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a
    specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.
    Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory
    genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of
    CBX5 (HP1 alpha) from chromatin1
  • Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
    • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes
    • place on H3K4me3 and results in gene repression (PubMed:22483618)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P68431

    • HIST1H3D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003521.2  
    ENSEMBL proteins: 
     ENSP00000366999   ENSP00000367062  
    Reactome Protein details: P68431
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HIST1H3D
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    Novus Biologicals HIST1H3D Proteins
    Novus Biologicals HIST1H3D Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H3D

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----


    HIST1H3D for ontologies           About GeneDecksing



    HIST1H3D Antibody Products: 
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    Novus Biologicals HIST1H3D Antibodies
    Abcam antibodies for HIST1H3D 
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    Assay Products for HIST1H3D: 
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    Uscn ELISAs and CLIAs for HIST1H3D

    Protein Domains /
    Families
    for HIST1H3D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H3D for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P68431

    ProtoNet protein and cluster: P68431

    UniProtKB/Swiss-Prot: H31_HUMAN, P68431
    Similarity: Belongs to the histone H3 family


    Function
    for HIST1H3D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H31_HUMAN, P68431
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H3D
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H3D:
    hsa-miR-146a* hsa-miR-1276
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HIST1H3D

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----


    HIST1H3D for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for HIST1H3D:
     Increased S DNA content  Increased number of cells in m  S arrest 


    Pathways & Interactions
    for HIST1H3D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1UVA-Induced MAPK Signaling
    		UVA-Induced MAPK Signaling1.00
    		UVB-Induced MAPK Signaling0.38
    2Interferon Pathway
    		Interferon Pathway1.00
    3Systemic lupus erythematosus
    		Systemic lupus erythematosus1.00
    4Rho Family GTPases
    		ERK Signaling0.61
    5TGF-Beta Pathway
    		MAPK Family Pathway0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H3D (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    5/6        Reactome Pathways for HIST1H3D (see all 6)
        Amyloids
    Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Meiosis
    Meiotic Recombination


    1         Kegg Pathway  (Kegg details for HIST1H3D):
        Systemic lupus erythematosus


    HIST1H3D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H3D

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/185 Interacting proteins for HIST1H3D (P684311, 2, 3 ENSP000003669994) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC101Q96ES72, 3MINT-8208820 MINT-8208994 MINT-8209533 MINT-8209481 MINT-8208878 MINT-8208960 MINT-8209125 MINT-8209567 MINT-8208901 MINT-8209070 MINT-8209550 MINT-8208976 MINT-8209091 MINT-8209584 MINT-8209261 MINT-8209449 MINT-8209516 MINT-8208834 MINT-8209427 MINT-8208806 MINT-8208846 MINT-8208860 MINT-8209498 MINT-8209465 MINT-8209145 MINT-8208780 I2D: score=1 
    AIREO439182, 3MINT-6542493 MINT-6542602 MINT-6542217 MINT-6542176 MINT-6542437 MINT-6542623 MINT-6542513 MINT-6542121 MINT-6542585 MINT-6542551 MINT-6542098 MINT-6542155 MINT-6542420 MINT-6542202 MINT-6542385 MINT-6542408 MINT-6542567 MINT-6542476 MINT-6542533 MINT-6542137 I2D: score=3 
    HIST1H4BP628052, 3, ENSP000003665814MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000366581
    HIST1H4AP628052, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H4CP628052, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----
    GO:0007596blood coagulation ----
    GO:0051320S phase ----
    GO:0060968regulation of gene silencing ----


    HIST1H3D for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H3D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H3D
    Search CenterWatch for drugs/clinical trials and news about HIST1H3D / H31 

    Transcripts
    for HIST1H3D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H3D gene: 
    NM_003530.4  

    Unigene Cluster for HIST1H3D:

    Histone cluster 1, H3d
    Hs.532144  [show with all ESTs]
    Unigene Representative Sequence: BQ051491
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356476(uc021ymt.1) ENST00000377831(uc003ngv.3)

    miRNA
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    hsa-miR-146a* hsa-miR-1276
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    Inhib. RNA
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    OriGene siRNA: HIST1H3D
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK316611.1 BC031333.1 

    2 DOTS entries:

    DT.100017852  DT.99930490 

    24/30 AceView cDNA sequences (see all 30):

    CA305925 BQ051491 CR541999 AI201724 CR541970 BP870844 NM_021065 AW135863 
    AW006409 BI253496 BC033095 BM852788 BX106526 AI800007 BC031333 NM_003530 
    AI351370 BE796394 BE378303 BM007476 AA779995 N35832 BI768916 CD694188 

    GeneLoc Exon Structure


    Expression
    for HIST1H3D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H3D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCAAGGACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST1H3D expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST1H3D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H3D

    SOURCE GeneReport for Unigene cluster: Hs.532144
        SABiosciences Custom PCR Arrays for HIST1H3D
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST1H3D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H3D gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NNM8_CHICK6
    		 Uncharacterized protein
    		 96(a)
    		 possible ortholog
    		 3(18255810-18259612)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1586291 zgc:158629 85.29(n)
    99.26(a)    		   570618  NM_001100173.1  NP_001093643.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea his-636
    his-256
    (see all 16)    		 Histone H3
    (see all 16)    		 97(a)
    97(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 IV(11406365-11406871)
    II(13824547-13825190)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G400401 histone H3 75.98(n)
    96.32(a)    		   830165  NM_179198.1  NP_849529.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g01309001 hypothetical protein 81.86(n)
    96.32(a)    		   4340006  NM_001063228.1  NP_001056693.1 


    ENSEMBL Gene Tree for HIST1H3D (if available)
    TreeFam Gene Tree for HIST1H3D (if available) 

    Paralogs
    for HIST1H3D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H3D gene
    HIST1H3G1 2  HIST1H3I1 2  HIST1H3F1 2  HIST1H3H1 2  HIST1H3B1 2  HIST1H3E1 2  HIST1H3A1 2  HIST1H3J1 2  
    HIST1H3C1 2  HIST2H3C2  H3F3C2  HIST2H3D2  HIST3H32  H3F3A2  H3F3B2  HIST2H3A2  
    9 SIMAP similar genes for HIST1H3D using alignment to 1 protein entry:     H31_HUMAN:
    HIST3H3    H3F3B    H3F3A    HIST2H3A    HIST2H3C    HIST2H3D
    HIST2H3PS2    H3F3C    CENPA

    HIST1H3D for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H3D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/33 NCBI SNPs in HIST1H3D are shown (see all 33)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796976291,2
    		C,--26196512(+) TGAATA/GAAGTT 1 -- ds50013Minor allele frequency- G:0.05CSA WA NA 240
    rs1823021121,2
    		--26196565(+) CAGCGC/TCTCAG 1 -- ds50010--------
    rs1137389351,2
    		C,--26196567(+) GCGCCT/ACAGGT 1 -- ds50012Minor allele frequency- A:0.08CSA NA 122
    rs675759651,2
    		C,F,--26196593(+) CAGGCA/GGTGTT 1 -- ds50018Minor allele frequency- G:0.18NA CSA WA EA 367
    rs1143026731,2
    		C,F,--26196824(+) GGCCCC/ACAAAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1869751631,2
    		--26196892(+) GCTTTC/TTGCAC 1 -- ds50010--------
    rs1910028151,2
    		--26196962(+) ACAGAA/GGTTCC 1 -- ds50010--------
    rs745269841,2
    		C,--26197013(+) AAGGTG/TGTTGG 1 -- ut310--------
    rs2001328271,2
    		--26197038(+) TTTGGA/GTTTTG 1 -- ut310--------
    rs1840406011,2
    		C,--26197074(+) TACGCC/TCTCTC 2 R syn10--------

    HapMap Linkage Disequilibrium report for HIST1H3D (26197012 - 26199521 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HIST1H3D
         1 CNV: 51865

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    Disorders / Diseases
    for HIST1H3D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H3D for disorders           About GeneDecksing

    OMIM gene information: 602811    OMIM disorders: --

    3 diseases for HIST1H3D:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    immunodeficiency


    Export disorders for HIST1H3D gene to outside databases

    Publications
    for HIST1H3D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H3D gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with HIST1H3D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    5. Histone H3 lysine 56 methylation regulates DNA replication through its interaction wwith PCNA. (PubMed id 22387026)2 Yu Y.... Grunstein M. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. (PubMed id 22483618)2 Herranz N.... Peiro S. (2012)
    8. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
    9. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    10. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)

    External Searches for HIST1H3D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H3D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8351 HGNC: 4767 AceView: HIST1H3D Ensembl:ENSG00000197409 euGenes: HUgn8351
    ECgene: HIST1H3D Kegg: 8351 H-InvDB: HIST1H3D

    Other Databases showing HIST1H3D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H3D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H3D Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H3D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H3D gene:
    Search GeneIP for patents involving HIST1H3D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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