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HIST1H3A Gene

protein-coding   GIFtS: 52
GCID: GC06P026020

Histone Cluster 1, H3a

(Previous names: H3 histone family, member A, histone 1, H3a)
(Previous symbol: H3FA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H3a1 2     H3FJ3
H3FA1 2 3 5     H3FK3
H3 Histone Family, Member A1 2     H3FL3
Histone 1, H3a1 2     Histone H3/B3
Histone H3/A2 3     Histone H3/C3
H3/A2     Histone H3/D3
Histone H3.12     Histone H3/F3
H3FB3     Histone H3/H3
H3FC3     Histone H3/I3
H3FD3     Histone H3/J3
H3FF3     Histone H3/K3
H3FH3     Histone H3/L3
H3FI3     

External Ids:    HGNC: 47661   Entrez Gene: 83502   Ensembl: ENSG000001983667   OMIM: 6028105   UniProtKB: P684313   

Export aliases for HIST1H3A gene to outside databases

Previous GC identifers: GC06P026078 GC06P026083 GC06P026128 GC06P025963


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H3A Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer
composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further
compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher
order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts
from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in
the large histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H3A Gene:
HIST1H3A (histone cluster 1, H3a) is a protein-coding gene. Diseases associated with HIST1H3A include cockayne syndrome, and vasculitis. An important paralog of this gene is HIST2H3C.

UniProtKB/Swiss-Prot: H31_HUMAN, P68431
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H3A gene promoter:
         Pax-5   Egr-4   CREB   CBF-B   CBF-A   deltaCREB   CP1C   CP1A   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H3A promoter sequence
   Search Chromatin IP Primers for HIST1H3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H3A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026020:  view genomic region     (about GC identifiers)

Start:
26,020,718 bp from pter      End:
26,021,186 bp from pter
Size:
469 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H31_HUMAN, P68431 (See protein sequence)
Recommended Name: Histone H3.1  
Size: 136 amino acids; 15404 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down
during the process of differentiation
Miscellaneous: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation
of Lys-10 (H3K9me2)
Selected PDB 3D structures from and Proteopedia for HIST1H3A (see all 74):
1CS9 (3D)        1CT6 (3D)        1Q3L (3D)        2B2T (3D)        2B2U (3D)        2B2V (3D)    
Secondary accessions: A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3
Q93081

Explore the universe of human proteins at neXtProt for HIST1H3A: NX_P68431

Explore proteomics data for HIST1H3A at MOPED

Post-translational modifications: 

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).
    Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the
    surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at
    Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is
    linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is
    present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while
    it is absent on active promoters1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated
    with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me)
    and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1
    proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3
    and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at
    'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
    Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for
    DNA replication1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression
    during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important
    during interphase because it enables the transcription of genes following external stimulation, like mitogens,
    stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.
    Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)
    but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation
    of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an
    essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK
    isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)
    by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5
    (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early
    anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic
    transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at
    Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by
    modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5
    (HP1 alpha) from chromatin1
  • Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By
    similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken
    the interaction between histones and DNA and facilitate DNA accessibility to repair proteins1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only
    takes place on H3K4me3 and results in gene repression (PubMed:22483618)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST1H3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003520.1  
    ENSEMBL proteins: 
     ENSP00000350275  
    Reactome Protein details: P68431

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    Cloud-Clone Corp. Proteins for HIST1H3A

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H3A
    Cloud-Clone Corp. CLIAs for HIST1H3A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P68431

    ProtoNet protein and cluster: P68431

    UniProtKB/Swiss-Prot: H31_HUMAN, P68431
    Similarity: Belongs to the histone H3 family


    HIST1H3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H31_HUMAN, P68431
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H3A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H3A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H3A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H3A

    miRNA
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    miRTarBase miRNAs that target HIST1H3A:
    hsa-mir-3909 (MIRT052885), hsa-mir-1229-3p (MIRT036260), hsa-mir-34a-5p (MIRT025485)

    Block miRNA regulation of human, mouse, rat HIST1H3A using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H3A:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: HIST1H3A (NM_003529)
    Sino Biological Human cDNA Clone for HIST1H3A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H31_HUMAN, P68431: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005654nucleoplasm ----

    HIST1H3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H3A About   (see all 18)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    2Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74
    5UVA-Induced MAPK Signaling
    UVB-Induced MAPK Signaling0.38
    UVA-Induced MAPK Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H3A (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    2 Cell Signaling Technology (CST) Pathways for HIST1H3A
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control


    Selected Reactome Pathways for HIST1H3A (see all 13)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    Meiotic recombination
    formation of the beta-catenin:TCF transactivating complex
    Oxidative Stress Induced Senescence


    3 Kegg Pathways  (Kegg details for HIST1H3A):
        Alcoholism
    Transcriptional misregulation in cancer
    Systemic lupus erythematosus


    HIST1H3A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H3A
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H3A (P684311, 2, 3 ENSP000003502754) via UniProtKB, MINT, STRING, and/or I2D (see all 248)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC101Q96ES71, 2, 3EBI-79722,EBI-743117 MINT-8208820 MINT-8208994 MINT-8209533 MINT-8209481 MINT-8208878 MINT-8208960 MINT-8209125 MINT-8209567 MINT-8208901 MINT-8209070 MINT-8209550 MINT-8208976 MINT-8209091 MINT-8209584 MINT-8209261 MINT-8209449 MINT-8209516 MINT-8208834 MINT-8208806 MINT-8208846 MINT-8208860 MINT-8209427 MINT-8209498 MINT-8209465 MINT-8209145 MINT-8208780 I2D: score=1 
    AIREO439181, 2, 3, ENSP000002915824EBI-79722,EBI-1753081 MINT-6542493 MINT-6542602 MINT-6542217 MINT-6542176 MINT-6542437 MINT-6542623 MINT-6542513 MINT-6542121 MINT-6542585 MINT-6542551 MINT-6542098 MINT-6542155 MINT-6542420 MINT-6542202 MINT-6542385 MINT-6542408 MINT-6542567 MINT-6542476 MINT-6542533 MINT-6542137 I2D: score=3 STRING: ENSP00000291582
    WDR5P619641, 2, 3, ENSP000003514464EBI-79722,EBI-540834 MINT-3319451 MINT-3293300 MINT-3293375 MINT-3319546 MINT-3293337 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319477 I2D: score=2 STRING: ENSP00000351446
    HIST1H4HP628052, 3, ENSP000002893524MINT-6543302 MINT-7220359 I2D: score=7 STRING: ENSP00000289352
    HIST1H4BP628052, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----
    GO:0007596blood coagulation ----
    GO:0060968regulation of gene silencing ----

    HIST1H3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H3A (H31)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H3A gene: 
    NM_003529.2  

    Unigene Cluster for HIST1H3A:

    Histone cluster 1, H3a
    Hs.546315  [show with all ESTs]
    Unigene Representative Sequence: CD671279
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357647(uc003nfp.1)
    miRNA
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    Additional mRNA sequence: 

    BC066245.1 BC066246.1 BC066247.1 BC067490.1 BC067491.1 BC069303.1 CR541858.1 

    2 DOTS entries:

    DT.101984172  DT.91794018 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H3A expression in normal human tissues (normalized intensities)      HIST1H3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H3A Expression
    About this image


    HIST1H3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    HIST1H3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546315
        Custom PCR Arrays for HIST1H3A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H3A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h3a5
    Hist1h3d1
    histone cluster 1, H3a5
    histone cluster 1, H3d1
    86.52(n)1
    99.26(a)1
      13 (9.91 cM)5
    3191491  NM_178204.11  NP_835511.11 
     237618535 
    chicken
    (Gallus gallus)
    Aves LOC7683331 histone H3.2-like 86.52(n)
    99.26(a)
      768333  XM_004937672.1  XP_004937729.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Histone H3
    96(a)
    1 → many
    GL343279.1(552493-552912)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004957881 histone H3.2-like 81.62(n)
    99.26(a)
      100495788  XM_004916983.1  XP_004917040.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1139841 zgc:113984 82.11(n)
    99.26(a)
      573997  NM_001025176.3  NP_001020347.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His3:CG338331 His3:CG33833 80.15(n)
    99.26(a)
      3772552  NM_001032162.1  NP_001027333.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HTR111 HTR11 65.93(n)
    92.65(a)
      836660  NM_125933.2  NP_201338.1 


    ENSEMBL Gene Tree for HIST1H3A (if available)
    TreeFam Gene Tree for HIST1H3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H3A gene
    HIST2H3C2  H3F3C2  HIST2H3PS22  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST2H3D2  HIST1H3D2  
    HIST1H3H2  HIST3H32  H3F3A2  HIST1H3F2  HIST1H3I2  HIST1H3G2  HIST1H3C2  H3F3B2  
    HIST2H3A2  
    9 SIMAP similar genes for HIST1H3A using alignment to 1 protein entry:     H31_HUMAN:
    HIST3H3    H3F3B    H3F3A    HIST2H3A    HIST2H3C    HIST2H3D
    HIST2H3PS2    H3F3C    CENPA

    HIST1H3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H3A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602810    OMIM disorders: --

    12 diseases for HIST1H3A:    About MalaCards
    cockayne syndrome    vasculitis    mental retardation    systemic lupus erythematosus
    lupus erythematosus    hiv-1    pancreatic cancer    pancreatitis
    leukemia    endotheliitis    breast cancer    neuronitis


    HIST1H3A for disorders           About GeneDecksing


    Export disorders for HIST1H3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H3A gene, integrated from 10 sources (see all 233):
    (articles sorted by number of sources associating them with HIST1H3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (Genomics 1997)
    3. Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. (PubMed id 20228790)1, 2 Metzger E.... Schule R. (Nature 2010)
    4. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. (PubMed id 19783980)1, 2 Dawson M.A.... Kouzarides T. (Nature 2009)
    5. Double chromodomains cooperate to recognize the methylated histone H3 tail. (PubMed id 16372014)1, 2 Flanagan J.F.... Khorasanizadeh S. (Nature 2005)
    6. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PubMed id 16246723)1, 2 Macdonald N.... Mahadevan L.C. (Mol. Cell 2005)
    7. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PubMed id 15471871)1, 2 Ananthanarayanan M....Walsh M.J. (J. Biol. Chem. 2004)
    8. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. (PubMed id 11242053)1, 2 Lachner M.... Jenuwein T. (Nature 2001)
    9. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (Hum. Genet. 1997)
    10. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2 Albig W.... Doenecke D. (Genomics 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8350 HGNC: 4766 Ensembl:ENSG00000198366 euGenes: HUgn8350 ECgene: HIST1H3A Kegg: 8350
    H-InvDB: HIST1H3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H3A gene:
    Search GeneIP for patents involving HIST1H3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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