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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HIST1H3A Gene

protein-coding GIFtS: 52
GCID: GC06P026020

histone cluster 1, H3a

(Previous names: H3 histone family, member A, histone 1, H3a )
(Previous symbol: H3FA)

Explore 8 diseases affiliated with
HIST1H3A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histone Cluster 1, H3a¹ ²		H3FJ³
H3FA¹ ² ³ ⁵		H3FK³
H3/A¹ ²		H3FL³
H3 Histone Family, Member A¹ ²		Histone H3/B³
Histone 1, H3a¹ ²		Histone H3/C³
Histone H3/A² ³		Histone H3/D³
Histone H3.1²		Histone H3/F³
H3FB³		Histone H3/H³
H3FC³		Histone H3/I³
H3FD³		Histone H3/J³
H3FF³		Histone H3/K³
H3FH³		Histone H3/L³
H3FI³

External Ids:	HGNC: 4766¹	Entrez Gene: 8350²	Ensembl: ENSG00000198366⁷	OMIM: 602810⁵	UniProtKB: P68431³

Export aliases for HIST1H3A gene to outside databases

Previous GC identifers: GC06P026078 GC06P026083 GC06P026128 GC06P025963

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H3A:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in

eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of

pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the

interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.

This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails;

instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on

chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H31_HUMAN, P68431

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to

the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of

post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H3A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HIST1H3A gene promoter:
Pax-5 Egr-4 CREB CBF-B CBF-A deltaCREB CP1C CP1A Pax-4a CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H3A promoter sequence

Search SABiosciences Chromatin IP Primers for HIST1H3A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H3A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1

HIST1H3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H3A gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P026020: view genomic region (about GC identifiers)

Start:	26,020,718 bp from pter	End:	26,021,186 bp from pter
Size:	469 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H31_HUMAN, P68431 (See protein sequence)

Recommended Name: Histone H3.1

Size: 136 amino acids; 15404 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one

H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

Subcellular location: Nucleus. Chromosome

Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down during

the process of differentiation

Miscellaneous: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of

Lys-10 (H3K9me2)

6/55 PDB 3D structures from and Proteopedia for HIST1H3A (see all 55):

1CS9 (3D)

1CT6 (3D)

1Q3L (3D)

2B2T (3D)

2B2U (3D)

2B2V (3D)

Secondary accessions: A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3 Q93081

Explore the universe of human proteins at neXtProt for HIST1H3A: NX_P68431

Post-translational modifications:

Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9

(H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)¹

Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription¹

Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9

(H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to

gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the

3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on

active promoters¹

Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at

Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA

double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28

(H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1,

CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation

at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at

Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57

(H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication¹

Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation

at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and

meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because

it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV

irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which

is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.

Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from

heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell

transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon

ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional

activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at

Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a

specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.

Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory

genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of

CBX5 (HP1 alpha) from chromatin¹

Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).

Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction

between histones and DNA and facilitate DNA accessibility to repair proteins¹

Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes

place on H3K4me3 and results in gene repression (PubMed:22483618)¹

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,

including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active

promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with

post-meiotically activated genes on autosomes¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P68431

HIST1H3A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003520.1

ENSEMBL proteins:

ENSP00000350275

Reactome Protein details: P68431
Human Recombinant Protein Products:

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	Uscn Proteins for HIST1H3A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	--	--
GO:0005576	extracellular region	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	--	--

HIST1H3A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HIST1H3A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HIST1H3A for domains About GeneDecksing

3 InterPro domains/families:

IPR000164 Histone_H3

IPR009072 Histone-fold

IPR007125 Histone_core_D

Graphical View of Domain Structure for InterPro Entry P68431

ProtoNet protein and cluster: P68431

UniProtKB/Swiss-Prot: H31_HUMAN, P68431

Similarity: Belongs to the histone H3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: H31_HUMAN, P68431

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to

the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of

post-translational modifications of histones, also called histone code, and nucleosome remodeling

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H3A
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H3A

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0005515	protein binding	--	--

HIST1H3A for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

UVA-Induced MAPK Signaling

UVA-Induced MAPK Signaling

1.00

UVB-Induced MAPK Signaling

0.38

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Interferon Pathway

Interferon Pathway

1.00

Systemic lupus erythematosus

Systemic lupus erythematosus

1.00

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H3A (see all 8)

	Nuclear Receptor Activation by Vitamin-A
	PKA Signaling
	UVB-Induced MAPK Signaling
	Interferon Pathway
	Crosstalk Between CARM1 and ESRs

2 Cell Signaling Technology (CST) Pathways for HIST1H3A

	Chromatin Regulation / Acetylation
	Cell Cycle / Checkpoint Control

5/6 Reactome Pathways for HIST1H3A (see all 6)

	Amyloids
	Hemostasis
	Factors involved in megakaryocyte development and platelet production
	Meiosis
	Meiotic Recombination

1 Kegg Pathway (Kegg details for HIST1H3A):

Systemic lupus erythematosus

HIST1H3A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HIST1H3A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/206 Interacting proteins for HIST1H3A (P68431^{1, 2, 3} ENSP00000350275⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 206)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC101	Q96ES7²^,³	MINT-8208820 MINT-8208994 MINT-8209533 MINT-8209481 MINT-8208878 MINT-8208960 MINT-8209125 MINT-8209567 MINT-8208901 MINT-8209070 MINT-8209550 MINT-8208976 MINT-8209091 MINT-8209584 MINT-8209261 MINT-8209449 MINT-8209516 MINT-8208834 MINT-8209427 MINT-8208806 MINT-8208846 MINT-8208860 MINT-8209498 MINT-8209465 MINT-8209145 MINT-8208780 I2D: score=1
HIST1H4B	P62805²^,³	MINT-6543302 MINT-7220359 I2D: score=7
HIST1H4C	P62805²^,³	MINT-6543302 MINT-7220359 I2D: score=7
HIST1H4D	P62805²^,³	MINT-6543302 MINT-7220359 I2D: score=7
HIST1H4E	P62805²^,³	MINT-6543302 MINT-7220359 I2D: score=7

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	--	--
GO:0007596	blood coagulation	--	--
GO:0051320	S phase	--	--
GO:0060968	regulation of gene silencing	--	--

HIST1H3A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HIST1H3A
Search CenterWatch for drugs/clinical trials and news about HIST1H3A / H31

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HIST1H3A gene:

NM_003529.2

Unigene Cluster for HIST1H3A:

Histone cluster 1, H3a

Hs.546315 [show with all ESTs]

Unigene Representative Sequence: CD671279

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000357647(uc003nfp.1)

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H3A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H3A

Additional cDNA sequence:

BC066245.1 BC066246.1 BC066247.1 BC067490.1 BC067491.1 BC069303.1 CR541858.1

2 DOTS entries:

DT.101984172 DT.91794018

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HIST1H3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

HIST1H3A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HIST1H3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIST1H3A

SOURCE GeneReport for Unigene cluster: Hs.546315

SABiosciences Custom PCR Arrays for HIST1H3A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H3A gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NNM8_CHICK⁶	Uncharacterized protein	96(a)	possible ortholog	3(18255810-18259612)
zebrafish (Danio rerio)	Actinopterygii	LOC563243¹	histone H3.2-like	83.58(n) 99.26(a)		563243 XM_686609.1 XP_691701.1
worm (Caenorhabditis elegans)	Secernentea	his-32⁶ his-2⁶ (see all 16)	Histone H3 (see all 16)	97(a) 97(a) (see all 16)	many ↔ many many ↔ many (see all 16)	IV(8334285-8334752) V(16041808-16042263)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G40040¹	histone H3	74.51(n) 96.32(a)		830165 NM_179198.1 NP_849529.1
rice (Oryza sativa)	Liliopsida	Os06g0130900¹	hypothetical protein	80.88(n) 96.32(a)		4340006 NM_001063228.1 NP_001056693.1

ENSEMBL Gene Tree for HIST1H3A (if available)
TreeFam Gene Tree for HIST1H3A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HIST1H3A gene

HIST1H3D¹ ² HIST1H3F¹ ² HIST1H3I¹ ² HIST1H3G¹ ² HIST1H3H¹ ² HIST1H3E¹ ² HIST1H3B¹ ² HIST1H3J¹ ²

HIST1H3C¹ ² HIST2H3C² H3F3C² HIST2H3D² HIST3H3² H3F3A² H3F3B² HIST2H3A²

9 SIMAP similar genes for HIST1H3A using alignment to 1 protein entry: H31_HUMAN:

HIST3H3 H3F3B H3F3A HIST2H3A HIST2H3C HIST2H3D

HIST2H3PS2 H3F3C CENPA

HIST1H3A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117955237^1,2	C,F,	--	26020258(+)	`GAATTG/AGGGAA`	2	--	us2k¹		1		EA	120
rs4145405^1,2	C,H	--	26020276(-)	`ATTCCA/CAAGGT`	2	--	us2k¹		5		NS EA NA	420
rs187619294^1,2		--	26020280(+)	`TTGGAA/TTCAAT`	2	--	us2k¹		0	--	--	--	--
rs192542510^1,2		--	26020310(+)	`AAACAC/TAGCCT`	2	--	us2k¹		0	--	--	--	--
rs2157050^1,2	C,F,A,H,	--	26020431(-)	`TCAAAG/AGATCT`	2	--	us2k¹		21		NS EA NA WA CSA	2334
rs182730217^1,2		--	26020487(+)	`AAATAA/GTAGTA`	2	--	us2k¹		0	--	--	--	--
rs73736514^1,2	C,	--	26020551(+)	`GCCGGC/TGAAAC`	2	--	us2k¹		1		WA	2
rs187364157^1,2		--	26020647(+)	`TTACAA/CACTAT`	2	--	us2k¹		0	--	--	--	--
rs192261548^1,2		--	26020648(+)	`TACACA/TCTATA`	2	--	us2k¹		0	--	--	--	--
rs113936133^1,2	C,	--	26020668(+)	`GCTCAT/CGGGCG`	2	--	us2k¹		2		CSA EA	122

HapMap Linkage Disequilibrium report for HIST1H3A (26020718 - 26021186 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIST1H3A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HIST1H3A for disorders           About GeneDecksing

OMIM gene information: 602810    OMIM disorders: --

8 diseases for HIST1H3A:    About MalaCards

systemic lupus erythematosus lupus erythematosus cockayne syndrome pancreatic cancer

pancreatitis immunodeficiency leukemia neuronitis

Export disorders for HIST1H3A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HIST1H3A gene, integrated from 9 sources (see all 215):
(articles sorted by number of sources associating them with HIST1H3A)

Utopia: connect your pdf to the dynamic
world of online information

The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F....Maltais L.J. (2002)
Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)^{1, 2, 3} Albig W.... Doenecke D. (1997)
Phosphorylation of histone H3T6 by PKCbeta(I) control s demethylation at histone H3K4. (PubMed id 20228790)^{1, 2} Metzger E....SchA1le R. (2010)
JAK2 phosphorylates histone H3Y41 and excludes HP1alp ha from chromatin. (PubMed id 19783980)^{1, 2} Dawson M.A....Kouzarides T. (2009)
Double chromodomains cooperate to recognize the methylated histone H3 tail. (PubMed id 16372014)^{1, 2} Flanagan J.F.... Khorasanizadeh S. (2005)
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PubMed id 16246723)^{1, 2} Macdonald N.... Mahadevan L.C. (2005)
Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PubMed id 15471871)^{1, 2} Ananthanarayanan M....Walsh M.J. (2004)
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. (PubMed id 11242053)^{1, 2} Lachner M.... Jenuwein T. (2001)
The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)^{1, 2} Albig W. and Doenecke D. (1997)
Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)^{1, 2} Albig W....Doenecke D. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8350	HGNC: 4766	Ensembl:ENSG00000198366	euGenes: HUgn8350	ECgene: HIST1H3A	Kegg: 8350
H-InvDB: HIST1H3A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HIST1H3A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HIST1H3A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HIST1H3A gene:
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histone cluster 1, H3a

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HIST1H3A (Gene Symbol)
Histone Cluster 1, H3a
H3FA
H3/A
H3 Histone Family, Member A
Histone 1, H3a
Histone H3/A
Histone H3.1
H3FB
H3FC
H3FD
H3FF
H3FH
H3FI
H3FJ
H3FK
H3FL
Histone H3/B
Histone H3/C
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Histone H3/K
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HIST1H3A Gene

histone cluster 1, H3a

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