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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H3A Gene

protein-coding   GIFtS: 51
GCID: GC06P026020

Histone Cluster 1, H3a

(Previous names: H3 histone family, member A, histone 1, H3a)
(Previous symbol: H3FA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H3a1 2     H3FJ3
H3FA1 2 3 5     H3FK3
H3 Histone Family, Member A1 2     H3FL3
Histone 1, H3a1 2     Histone H3/B3
Histone H3/A2 3     Histone H3/C3
H3/A2     Histone H3/D3
Histone H3.12     Histone H3/F3
H3FB3     Histone H3/H3
H3FC3     Histone H3/I3
H3FD3     Histone H3/J3
H3FF3     Histone H3/K3
H3FH3     Histone H3/L3
H3FI3     

External Ids:    HGNC: 47661   Entrez Gene: 83502   Ensembl: ENSG000001983667   OMIM: 6028105   UniProtKB: P684313   

Export aliases for HIST1H3A gene to outside databases

Previous GC identifers: GC06P026078 GC06P026083 GC06P026128 GC06P025963


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H3A Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer
composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further
compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher
order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts
from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in
the large histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H3A Gene: 
HIST1H3A (histone cluster 1, H3a) is a protein-coding gene. Diseases associated with HIST1H3A include vasculitis, and mental retardation, and among its related super-pathways are UVB-Induced MAPK Signaling and Systemic lupus erythematosus. An important paralog of this gene is HIST2H3D.

UniProtKB/Swiss-Prot: H31_HUMAN, P68431
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H3A gene promoter:
         Pax-5   Egr-4   CREB   CBF-B   CBF-A   deltaCREB   CP1C   CP1A   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H3A promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H3A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026020:  view genomic region     (about GC identifiers)

Start:
26,020,718 bp from pter      End:
26,021,186 bp from pter
Size:
469 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H31_HUMAN, P68431 (See protein sequence)
Recommended Name: Histone H3.1  
Size: 136 amino acids; 15404 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down
during the process of differentiation
Miscellaneous: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation
of Lys-10 (H3K9me2)
6/56 PDB 3D structures from and Proteopedia for HIST1H3A (see all 56):
1CS9 (3D)        1CT6 (3D)        1Q3L (3D)        2B2T (3D)        2B2U (3D)        2B2V (3D)    
Secondary accessions: A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3
Q93081

Explore the universe of human proteins at neXtProt for HIST1H3A: NX_P68431

Explore proteomics data for HIST1H3A at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)
  • UniProtKB: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription
  • UniProtKB: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at
    Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is
    linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is
    present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while
    it is absent on active promoters
  • UniProtKB: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated
    with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me)
    and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1
    proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3
    and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at
    'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
    Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for
    DNA replication
  • UniProtKB: Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression
    during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important
    during interphase because it enables the transcription of genes following external stimulation, like mitogens,
    stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.
    Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)
    but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation
    of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an
    essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK
    isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)
    by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5
    (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early
    anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic
    transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at
    Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by
    modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5
    (HP1 alpha) from chromatin
  • UniProtKB: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By
    similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken
    the interaction between histones and DNA and facilitate DNA accessibility to repair proteins
  • UniProtKB: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only
    takes place on H3K4me3 and results in gene repression (PubMed:22483618)
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P68431

  • HIST1H3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H3A Protein Expression
    REFSEQ proteins: NP_003520.1  
    ENSEMBL proteins: 
     ENSP00000350275  
    Reactome Protein details: P68431
    Human Recombinant Protein Products for HIST1H3A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for HIST1H3A
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    Novus Biologicals HIST1H3A Lysate
    Sino Biological Recombinant Protein for HIST1H3A
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H3A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005576extracellular region ----
    GO:0005654nucleoplasm ----

    HIST1H3A for ontologies           About GeneDecksing



    HIST1H3A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H3A
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    Novus Biologicals HIST1H3A Antibodies
    Abcam antibodies for HIST1H3A
    Cloud-Clone Corp. Antibodies for HIST1H3A 
    ThermoFisher Antibodies for HIST1H3A
    Search LSBio for Antibodies for HIST1H3A 

    Assay Products for HIST1H3A: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H3A 
    Cloud-Clone Corp. CLIAs for HIST1H3A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P68431

    ProtoNet protein and cluster: P68431

    UniProtKB/Swiss-Prot: H31_HUMAN, P68431
    Similarity: Belongs to the histone H3 family


    HIST1H3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H31_HUMAN, P68431
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H3A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H3A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H3A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H3A 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H3A
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    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H3A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H3A About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1UVA-Induced MAPK Signaling
    UVB-Induced MAPK Signaling0.38
    UVA-Induced MAPK Signaling0.38
    2Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    3Rho Family GTPases
    ERK Signaling0.61
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H3A (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    2 Cell Signaling Technology (CST) Pathways for HIST1H3A
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control


    5/6        Reactome Pathways for HIST1H3A (see all 6)
        Amyloids
    Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Meiosis
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H3A):
        Alcoholism
    Transcriptional misregulation in cancer
    Systemic lupus erythematosus


    HIST1H3A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/211 Interacting proteins for HIST1H3A (P684311, 2, 3 ENSP000003502754) via UniProtKB, MINT, STRING, and/or I2D (see all 211)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC101Q96ES72, 3MINT-8208820 MINT-8208994 MINT-8209533 MINT-8209481 MINT-8208878 MINT-8208960 MINT-8209125 MINT-8209567 MINT-8208901 MINT-8209070 MINT-8209550 MINT-8208976 MINT-8209091 MINT-8209584 MINT-8209261 MINT-8209449 MINT-8209516 MINT-8208834 MINT-8209427 MINT-8208806 MINT-8208846 MINT-8208860 MINT-8209498 MINT-8209465 MINT-8209145 MINT-8208780 I2D: score=1 
    AIREO439182, 3, ENSP000002915824MINT-6542493 MINT-6542602 MINT-6542217 MINT-6542176 MINT-6542437 MINT-6542623 MINT-6542513 MINT-6542121 MINT-6542585 MINT-6542551 MINT-6542098 MINT-6542155 MINT-6542420 MINT-6542202 MINT-6542385 MINT-6542408 MINT-6542567 MINT-6542476 MINT-6542533 MINT-6542137 I2D: score=3 STRING: ENSP00000291582
    HIST1H4BP628052, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H4CP628052, 3MINT-6543302 MINT-7220359 I2D: score=7 
    HIST1H4DP628052, 3MINT-6543302 MINT-7220359 I2D: score=7 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----
    GO:0007596blood coagulation ----
    GO:0051320S phase ----
    GO:0060968regulation of gene silencing ----

    HIST1H3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H3A (H31)

    Search CenterWatch for drugs/clinical trials and news about HIST1H3A / H31

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H3A gene: 
    NM_003529.2  

    Unigene Cluster for HIST1H3A:

    Histone cluster 1, H3a
    Hs.546315  [show with all ESTs]
    Unigene Representative Sequence: CD671279
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357647(uc003nfp.1)
    miRNA
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    Additional mRNA sequence: 

    BC066245.1 BC066246.1 BC066247.1 BC067490.1 BC067491.1 BC069303.1 CR541858.1 

    2 DOTS entries:

    DT.101984172  DT.91794018 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H3A expression in normal human tissues (normalized intensities)      HIST1H3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H3A Expression
    About this image


    HIST1H3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord

    See HIST1H3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H3A

    SOURCE GeneReport for Unigene cluster: Hs.546315
        SABiosciences Custom PCR Arrays for HIST1H3A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H3A gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h3a5
    Hist1h3h1
    histone cluster 1, H3a5
    histone cluster 1, H3h1
    87.01(n)1
    100(a)1
      13 (9.91 cM)5
    3191521  NM_178206.21  NP_835513.11 
     237618535 
    lizard
    (Anolis carolinensis)
    Reptilia HIST2H3A6
    Histone H3
    96(a)
    1 → many
    GL343279.1(552493-552912)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5632431 histone H3.2-like 83.58(n)
    99.26(a)
      563243  XM_686609.1  XP_691701.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G400401 histone H3 74.51(n)
    96.32(a)
      830165  NM_179198.1  NP_849529.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01309001 hypothetical protein 80.88(n)
    96.32(a)
      4340006  NM_001063228.1  NP_001056693.1 


    ENSEMBL Gene Tree for HIST1H3A (if available)
    TreeFam Gene Tree for HIST1H3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H3A gene
    HIST1H3D1 2  HIST1H3F1 2  HIST1H3I1 2  HIST1H3G1 2  HIST1H3H1 2  HIST1H3E1 2  HIST1H3B1 2  HIST1H3J1 2  
    HIST1H3C1 2  HIST2H3D2  HIST2H3C2  H3F3C2  HIST3H32  H3F3A2  H3F3B2  HIST2H3A2  
    9 SIMAP similar genes for HIST1H3A using alignment to 1 protein entry:     H31_HUMAN:
    HIST3H3    H3F3B    H3F3A    HIST2H3A    HIST2H3C    HIST2H3D
    HIST2H3PS2    H3F3C    CENPA

    HIST1H3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H3A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602810    OMIM disorders: --

    10 diseases for HIST1H3A:    About MalaCards
    vasculitis    mental retardation    systemic lupus erythematosus    lupus erythematosus
    pancreatic cancer    pancreatitis    endotheliitis    leukemia
    breast cancer    neuronitis


    HIST1H3A for disorders           About GeneDecksing


    Export disorders for HIST1H3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H3A gene, integrated from 9 sources (see all 228):
    (articles sorted by number of sources associating them with HIST1H3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. Phosphorylation of histone H3T6 by PKCbeta(I) control s demethylation at histone H3K4. (PubMed id 20228790)1, 2 Metzger E....SchA1le R. (2010)
    4. JAK2 phosphorylates histone H3Y41 and excludes HP1alp ha from chromatin. (PubMed id 19783980)1, 2 Dawson M.A....Kouzarides T. (2009)
    5. Double chromodomains cooperate to recognize the methylated histone H3 tail. (PubMed id 16372014)1, 2 Flanagan J.F.... Khorasanizadeh S. (2005)
    6. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PubMed id 16246723)1, 2 Macdonald N.... Mahadevan L.C. (2005)
    7. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PubMed id 15471871)1, 2 Ananthanarayanan M....Walsh M.J. (2004)
    8. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. (PubMed id 11242053)1, 2 Lachner M.... Jenuwein T. (2001)
    9. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    10. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2 Albig W....Doenecke D. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8350 HGNC: 4766 Ensembl:ENSG00000198366 euGenes: HUgn8350 ECgene: HIST1H3A Kegg: 8350
    H-InvDB: HIST1H3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H3A gene:
    Search GeneIP for patents involving HIST1H3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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