Aliases for HIST1H3A Gene
Aliases for HIST1H3A Gene
- Histone Cluster 1 H3 Family Member A 2 3 5
- H3 Histone Family, Member A 2 3
- Histone Cluster 1, H3a 2 3
- Histone 1, H3a 2 3
- Histone H3/A 3 4
- H3FA 3 4
- HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J 4
- Histone H3.1 3
- Histone H3/B 4
- Histone H3/C 4
- Histone H3/D 4
- Histone H3/F 4
- Histone H3/H 4
- Histone H3/I 4
External Ids for HIST1H3A Gene
- HGNC: 4766
- Entrez Gene: 8350
- Ensembl: ENSG00000275714
- OMIM: 602810
- UniProtKB: P68431
Previous HGNC Symbols for HIST1H3A Gene
- H3FA
Previous GeneCards Identifiers for HIST1H3A Gene
- GC06P026078
- GC06P026083
- GC06P026128
- GC06P025963
Summaries for HIST1H3A Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H3A Gene
HIST1H3A (Histone Cluster 1 H3 Family Member A) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Meiosis. GO annotations related to this gene include protein heterodimerization activity and histone binding. An important paralog of this gene is HIST1H3H.
UniProtKB/Swiss-Prot for HIST1H3A Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H3A Gene
Genomics for HIST1H3A Gene
Regulatory Elements for HIST1H3A Gene
Enhancers for HIST1H3A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G025135 | 1.5 | FANTOM5 ENCODE dbSUPER | 6.2 | -883.0 | -882977 | 4.7 | HDGF TBP PKNOX1 TBL1XR1 ZSCAN4 WRNIP1 RAD21 YY1 RELB ETV6 | CMAHP HIST1H3A C6orf62 NUP50P2 ENSG00000230372 |
| GH06G026019 | 1.9 | FANTOM5 ENCODE dbSUPER | 2.2 | +7.1 | 7097 | 16.2 | CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 | ABT1 HMGN4 ENSG00000272462 BTN3A2 ZNF322 HIST1H1C BTN3A1 NUP50P2 HIST1H2APS5 BTN3A3 |
| GH06G026120 | 2.1 | FANTOM5 Ensembl ENCODE dbSUPER | 1.3 | +103.5 | 103485 | 7.8 | CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 SSRP1 | ABT1 ENSG00000272462 HMGN4 NUP50P2 ZNF322 HFE BTN3A2 HIST1H1C HIST1H2APS5 BTN3A1 |
| GH06G025535 | 1 | FANTOM5 | 1.9 | -484.9 | -484940 | 0.0 | PKNOX1 ATF1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 SMARCB1 SMARCA4 | RPL21P68 LOC101928663 CARMIL1 LOC100533655 CMAHP HIST1H4A HIST1H3B HIST1H4B HIST1H2AB HIST1H3A |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H3A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST1H3A Gene
- Chromosome:
- 6
- Start:
- 26,020,490 bp from pter
- End:
- 26,020,958 bp from pter
- Size:
- 469 bases
- Orientation:
- Plus strand
Genomic View for HIST1H3A Gene
Genes around HIST1H3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H3A Gene
Proteins for HIST1H3A Gene
-
Protein details for HIST1H3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68431-H31_HUMAN
- Recommended name:
- Histone H3.1
- Protein Accession:
- P68431
- A0PJT7
- A5PLR1
- P02295
- P02296
- P16106
- Q6ISV8
- Q6NWP8
- Q6NWP9
- Q6NXU4
- Q71DJ3
- Q93081
Protein attributes for HIST1H3A Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15404 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- Miscellaneous:
-
- This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
Protein Expression for HIST1H3A Gene
Post-translational modifications for HIST1H3A Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (PubMed:22483618).
- Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
- Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
- Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- Ubiquitination at posLast=116116
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H3A
- Cell Signaling Technology (CST) Antibodies for HIST1H3A (H3)
-
Custom Antibody ServicesOriGene Antibodies for HIST1H3A
- AP01606PU-N
- AP02460PU-N
- AP02460PU-S
- AP02665PU-N
- AP02665PU-S
- AP06169PU-N
- AP12620PU-N
- AP20891PU-N
- AP20892PU-N
- AP20893PU-N
- AP20982PU-N
- AP20983PU-N
- AP20984PU-N
- TA314735
- TA314736
- TA314737
- TA314738
- TA314739
- TA314740
- TA316501
- TA319430
- TA322844
- TA343093
- TA347146
- TA347147
- TA347148
- TA347149
- TA347150
- TA347151
- TA347152
- TA347153
- TA347154
- TA347155
- TA347156
- TA347157
- TA347158
- TA347159
- TA347160
- TA347161
- TA347162
- TA347163
- TA347164
- TA347165
- TA347166
- TA347167
- TA347168
- TA347169
- TA347170
- TA347171
- TA347172
- TA347173
- TA347174
- TA347175
- TA347176
- TA347177
- TA347178
- TA347179
- TA347180
- TA347181
- TA347182
- TA347183
- TA347184
- TA347185
- TA347186
- TA347187
- TA347188
- TA347189
- TA347190
- TA347191
- TA347192
- TA347193
- TA347194
- TA347195
- TA347196
- TA347197
- TA347198
- TA347199
- TA347200
- TA347201
- TA347202
- TA347203
- TA347204
- TA347205
- TA347206
- TA347808
- TA347809
- TA352118
- TA352119
- TA352120
- TA352241
- Novus Biologicals Antibodies for HIST1H3A
-
Abcam antibodies for HIST1H3A
- Invitrogen Antibodies for HIST1H3A
- antibodies-online Antibodies for HIST1H3A: See all 15
- GeneTex HIST1H3A antibody for HIST1H3A
-
Santa Cruz Biotechnology (SCBT) Antibodies for HIST1H3A
Protein Products
-
OriGene Purified Proteins for HIST1H3A
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H3A
- Origene Custom Protein Services for HIST1H3A
- Novus Biologicals lysates for HIST1H3A
- Sino Biological Recombinant Proteins for HIST1H3A
- Browse Sino Biological Cell Lysates
- antibodies-online Proteins for HIST1H3A: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIST1H3A
Assay Products
- Cell Signaling Technology (CST) Sandwich ELISA Kits for HIST1H3A (H3)
-
Abcam assays for HIST1H3A
No data available for DME Specific Peptides for HIST1H3A Gene
Domains & Families for HIST1H3A Gene
Gene Families for HIST1H3A Gene
- HGNC:
Protein Domains for HIST1H3A Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P68431- Family:
-
- Belongs to the histone H3 family.
No data available for Suggested Antigen Peptide Sequences for HIST1H3A Gene
Function for HIST1H3A Gene
Molecular function for HIST1H3A Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10949293 |
| GO:0042393 | histone binding | IPI | 20498094 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H3A Gene
- GenomeRNAi human phenotypes for HIST1H3A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3A gene
- Search ViGene Biosciences for HIST1H3A
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3A
- GenScript: Design CRISPR guide RNA sequences for HIST1H3A
miRNA for HIST1H3A Gene
- miRTarBase miRNAs that target HIST1H3A
-
- hsa-mir-34a-5p (MIRT025485)
- hsa-mir-1229-3p (MIRT036260)
- hsa-mir-3909 (MIRT052885)
- hsa-mir-5693 (MIRT523217)
- hsa-mir-6885-3p (MIRT523218)
- hsa-mir-8057 (MIRT523219)
- hsa-mir-4535 (MIRT523220)
- hsa-mir-4776-5p (MIRT523221)
- hsa-mir-1273e (MIRT523222)
- hsa-mir-6822-3p (MIRT523223)
- hsa-mir-4766-5p (MIRT523224)
- hsa-mir-146a-3p (MIRT523225)
- hsa-mir-3121-5p (MIRT523226)
- hsa-mir-1276 (MIRT523227)
- hsa-mir-760 (MIRT523228)
miRNA Products
- Search ViGene Biosciences for HIST1H3A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H3A
- Browse OriGene Inhibitory RNA Products For HIST1H3A
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3A gene
Clone Products
-
OriGene ORF clones in human for HIST1H3A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H3A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H3A
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H3A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3A gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H3A Gene
Localization for HIST1H3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H3A Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | IDA | 21636898 |
| GO:0000788 | nuclear nucleosome | IDA | 20498094 |
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for HIST1H3A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | Cellular Senescence | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Chromatin organization | ||
| 5 | Mitotic Prophase |
.57
|
|
Pathways by source for HIST1H3A Gene
2 Sino Biological pathways for HIST1H3A Gene
1 GeneTex pathway for HIST1H3A Gene
2 Cell Signaling Technology pathways for HIST1H3A Gene
1 BioSystems pathway for HIST1H3A Gene
54 Reactome pathways for HIST1H3A Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H3A Gene
8 Qiagen pathways for HIST1H3A Gene
Interacting Proteins for HIST1H3A Gene
SIGNOR curated interactions for HIST1H3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006325 | chromatin organization | TAS | -- |
| GO:0006334 | nucleosome assembly | IMP | 25615412 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0007596 | blood coagulation | TAS | -- |
Transcripts for HIST1H3A Gene
mRNA/cDNA for HIST1H3A Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H3A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3A
- GenScript: Design CRISPR guide RNA sequences for HIST1H3A
miRNA Products
- Search ViGene Biosciences for HIST1H3A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H3A
- Browse OriGene Inhibitory RNA Products For HIST1H3A
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3A gene
Clone Products
-
OriGene ORF clones in human for HIST1H3A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H3A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HIST1H3A Gene
This gene is overexpressed in Testis (x14.1) and Whole Blood (x4.8).
This gene is overexpressed in Heart (41.5), Urine (13.4), and Cervix (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H3A Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H3A Gene:
HIST1H3ASOURCE GeneReport for Unigene cluster for HIST1H3A Gene:
Hs.546315Evidence on tissue expression from TISSUES for HIST1H3A Gene
- Nervous system(4.5)
- Stomach(4.3)
- Blood(4.1)
- Spleen(4.1)
Primer Products
-
OriGene qPCR primer pairs for HIST1H3A
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H3A Gene
Orthologs for HIST1H3A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h3d 34 16 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC608586 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC471886 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC102549173 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC788077 34 |
|
||
| chicken (Gallus gallus) |
Aves | LOC768333 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495788 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:113984 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His3:CG33833 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | HTR11 34 |
|
- Species where no ortholog for HIST1H3A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST1H3A Gene
Paralogs for HIST1H3A Gene
(9) SIMAP similar genes for HIST1H3A Gene using alignment to 1 proteins:
Variants for HIST1H3A Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001157548 | -- | 26,018,849(+) | AGAAT(A/T)AAAAA | upstream-variant-2KB | |
| rs1001751186 | -- | 26,021,009(+) | ATTGG(A/G)AGCAC | downstream-variant-500B, upstream-variant-2KB | |
| rs1003023837 | -- | 26,021,387(+) | TTTAC(A/G)TTTAA | downstream-variant-500B, upstream-variant-2KB | |
| rs1004059208 | -- | 26,021,135(+) | CAGGA(G/T)TTCGG | downstream-variant-500B, upstream-variant-2KB | |
| rs1004310398 | -- | 26,021,224(+) | TAATC(C/T)CAGCT | downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv509122 | CNV | insertion | 20534489 |
Residual Variation Intolerance Score:
26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.73;
15.55% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H3A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H3A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H3A Gene
Disorders for HIST1H3A Gene
Relevant External Links for HIST1H3A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H3A
No disorders were found for HIST1H3A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H3A Gene
Publications for HIST1H3A Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
- Serine ADP-ribosylation depends on HPF1. (PMID: 28190768) Bonfiglio J.J. … Matic I. (Mol. Cell 2017) 3 4 64
- Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. (PMID: 23415232) Tropberger P. … Schneider R. (Cell 2013) 3 4 64
- Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. (PMID: 20228790) Metzger E. … Schule R. (Nature 2010) 3 4 64
Products for HIST1H3A Gene
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- Custom Antibody ServicesOriGene Antibodies for HIST1H3A
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- Cell Signaling Technology (CST) Antibodies for HIST1H3A (H3)
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- Novus Biologicals Antibodies for HIST1H3A
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- Abcam antibodies for HIST1H3A
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- Search knockout validated antibodies
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- antibodies-online Antibodies for HIST1H3A: See all 15
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- antibodies-online Proteins for HIST1H3A: See all 3
- Search antibodies-online for peptides
- GeneTex HIST1H3A antibody for HIST1H3A
- Search GeneTex for Proteins for HIST1H3A
- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H3A gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIST1H3A gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIST1H3A gene
- Search ViGene Biosciences for HIST1H3A
- Santa Cruz Biotechnology (SCBT) Antibodies for HIST1H3A
- Search Santa Cruz Biotechnology (SCBT) for HIST1H3A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H3A
- Horizon Cell Lines for HIST1H3A
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST1H3A
- VectorBuilder custom plasmid, inducible vectors for HIST1H3A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H3A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H3A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
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- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
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- (95) BioSystems
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- (100) COMPARTMENTS
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- (104) Addgene
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