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Aliases for HIST1H2BO Gene

Aliases for HIST1H2BO Gene

  • Histone Cluster 1, H2bo 2 3
  • H2BFN 3 4 6
  • H2B Histone Family, Member N 2 3
  • Histone 1, H2bo 2 3
  • Histone H2B.2 3 4
  • Histone H2B.N 3 4
  • H2B/N 3 4
  • Histone H2B Type 1-O 3
  • DJ193B12.2 3
  • H2BFH 4
  • H2B.2 3

External Ids for HIST1H2BO Gene

Previous Symbols for HIST1H2BO Gene

  • H2BFN

Summaries for HIST1H2BO Gene

Entrez Gene Summary for HIST1H2BO Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2BO Gene

HIST1H2BO (Histone Cluster 1, H2bo) is a Protein Coding gene. Diseases associated with HIST1H2BO include hiv-1. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for HIST1H2BO Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BO Gene

Genomics for HIST1H2BO Gene

Genomic Location for HIST1H2BO Gene

Start:
27,893,425 bp from pter
End:
27,893,891 bp from pter
Size:
467 bases
Orientation:
Plus strand

Genomic View for HIST1H2BO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2BO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BO Gene

Regulatory Elements for HIST1H2BO Gene

Proteins for HIST1H2BO Gene

  • Protein details for HIST1H2BO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23527-H2B1O_HUMAN
    Recommended name:
    Histone H2B type 1-O
    Protein Accession:
    P23527
    Secondary Accessions:
    • Q3KPI7
    • Q8TCV6

    Protein attributes for HIST1H2BO Gene

    Size:
    126 amino acids
    Molecular mass:
    13906 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    Miscellaneous:
    • The mouse orthologous protein seems not to exist

neXtProt entry for HIST1H2BO Gene

Proteomics data for HIST1H2BO Gene at MOPED

Post-translational modifications for HIST1H2BO Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113

Other Protein References for HIST1H2BO Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BO Gene

Domains for HIST1H2BO Gene

Gene Families for HIST1H2BO Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2BO Gene

Suggested Antigen Peptide Sequences for HIST1H2BO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23527

UniProtKB/Swiss-Prot:

H2B1O_HUMAN
Family:
  • Belongs to the histone H2B family.:
    • P23527
genes like me logo Genes that share domains with HIST1H2BO: view

Function for HIST1H2BO Gene

Molecular function for HIST1H2BO Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2BO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 1768865
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BO: view

Phenotypes for HIST1H2BO Gene

genes like me logo Genes that share phenotypes with HIST1H2BO: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2BO Gene

Localization for HIST1H2BO Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BO Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BO Gene COMPARTMENTS Subcellular localization image for HIST1H2BO gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 1768865
GO:0000788 nuclear nucleosome IBA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST1H2BO: view

Pathways for HIST1H2BO Gene

genes like me logo Genes that share pathways with HIST1H2BO: view

Pathways by source for HIST1H2BO Gene

1 GeneGo (Thomson Reuters) pathway for HIST1H2BO Gene
29 Reactome pathways for HIST1H2BO Gene
3 KEGG pathways for HIST1H2BO Gene

Interacting Proteins for HIST1H2BO Gene

Selected Interacting proteins: P23527-H2B1O_HUMAN for HIST1H2BO Gene via I2D

Gene Ontology (GO) - Biological Process for HIST1H2BO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly NAS 1768865
genes like me logo Genes that share ontologies with HIST1H2BO: view

Transcripts for HIST1H2BO Gene

mRNA/cDNA for HIST1H2BO Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2BO Gene

Histone cluster 1, H2bo:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BO Gene

No ASD Table

Relevant External Links for HIST1H2BO Gene

GeneLoc Exon Structure for
HIST1H2BO
ECgene alternative splicing isoforms for
HIST1H2BO

Expression for HIST1H2BO Gene

mRNA expression in normal human tissues for HIST1H2BO Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2BO Gene

This gene is overexpressed in Whole Blood (13.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HIST1H2BO Gene

SOURCE GeneReport for Unigene cluster for HIST1H2BO Gene Hs.484991

genes like me logo Genes that share expressions with HIST1H2BO: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST1H2BO Gene

Orthologs for HIST1H2BO Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H2BO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC462509 35
  • 99.74 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HIST2H2BE 35
  • 89.42 (n)
  • 99.21 (a)
dog
(Canis familiaris)
Mammalia LOC483169 35
  • 93.39 (n)
  • 99.21 (a)
mouse
(Mus musculus)
Mammalia Hist1h2bp 35
  • 90.21 (n)
  • 96.03 (a)
rat
(Rattus norvegicus)
Mammalia Hist1h2bo 35
  • 90.48 (n)
  • 98.41 (a)
chicken
(Gallus gallus)
Aves HIST1H2B7L2 35
  • 89.42 (n)
  • 96.03 (a)
zebrafish
(Danio rerio)
Actinopterygii hist2h2l 35
  • 82.8 (n)
  • 93.65 (a)
Species with no ortholog for HIST1H2BO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H2BO Gene

ENSEMBL:
Gene Tree for HIST1H2BO (if available)
TreeFam:
Gene Tree for HIST1H2BO (if available)

Paralogs for HIST1H2BO Gene

genes like me logo Genes that share paralogs with HIST1H2BO: view

No data available for Paralogs for HIST1H2BO Gene

Variants for HIST1H2BO Gene

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BO Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294

Relevant External Links for HIST1H2BO Gene

HapMap Linkage Disequilibrium report
HIST1H2BO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HIST1H2BO Gene

Disorders for HIST1H2BO Gene

(1) MalaCards Diseases for HIST1H2BO Gene

Search for HIST1H2BO Gene in MalaCards »
genes like me logo Genes that share disorders with HIST1H2BO: view

No data available for UniProtKB/Swiss-Prot for HIST1H2BO Gene

Publications for HIST1H2BO Gene

  1. A novel divergently transcribed human histone H2A/H2B gene pair. (PMID: 1768865) Dobner T. … Lipp M. (DNA Seq. 1991) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HIST1H2BO Gene

Sources for HIST1H2BO Gene

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