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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HIST1H2BO Gene

protein-coding GIFtS: 50
GCID: GC06P027861

histone cluster 1, H2bo

(Previous names: H2B histone family, member N, histone 1, H2bo )
(Previous symbol: H2BFN)

Explore 3 diseases affiliated with
HIST1H2BO via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histone Cluster 1, H2bo¹ ²		Histone H2B.2² ³
H2BFN¹ ² ³ ⁵		Histone H2B.N² ³
H2B/N¹		DJ193B12.2¹
H2B.2¹ ²		Histone H2B Type 1-O²
H2B Histone Family, Member N¹ ²		H2BFH³
Histone 1, H2bo¹ ²

External Ids:	HGNC: 4758¹	Entrez Gene: 8348²	Ensembl: ENSG00000196331⁷	OMIM: 602808⁵	UniProtKB: P23527³

Export aliases for HIST1H2BO gene to outside databases

Previous GC identifers: GC06P027919 GC06P027969 GC06P027668

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2BO:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in

eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which

approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with

linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is

intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead

contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome

6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2B1O_HUMAN, P23527

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to

the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of

post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BO

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HIST1H2BO gene promoter:
GR TBP Egr-3 Pax-5 AML1a GR-beta Evi-1 E47 FOXO4 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H2BO promoter sequence

Search SABiosciences Chromatin IP Primers for HIST1H2BO

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BO

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.1

HIST1H2BO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BO gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P027861: view genomic region (about GC identifiers)

Start:	27,861,203 bp from pter	End:	27,861,669 bp from pter
Size:	467 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H2B1O_HUMAN, P23527 (See protein sequence)

Recommended Name: Histone H2B type 1-O

Size: 126 amino acids; 13906 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one

H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

Subcellular location: Nucleus. Chromosome

Miscellaneous: The mouse orthologous protein seems not to exist

Secondary accessions: Q3KPI7 Q8TCV6

Explore the universe of human proteins at neXtProt for HIST1H2BO: NX_P23527

Post-translational modifications:

Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79'

(H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly,

monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional

activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively

with the FACT dimer to stimulate elongation by RNA polymerase II¹

Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).

Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation.

Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic

hypermutation and immunoglobulin class-switch recombination¹

GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose,

and associates with transcribed genes (By similarity)¹

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,

including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active

promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with

post-meiotically activated genes on autosomes¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23527

HIST1H2BO Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003518.2

ENSEMBL proteins:

ENSP00000303408

Reactome Protein details: P23527
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	Uscn Proteins for HIST1H2BO

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	NAS	1768865
GO:0005634	nucleus	IEA	--

HIST1H2BO for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HIST1H2BO

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HIST1H2BO for domains About GeneDecksing

3 InterPro domains/families:

IPR009072 Histone-fold

IPR000558 Histone_H2B

IPR007125 Histone_core_D

Graphical View of Domain Structure for InterPro Entry P23527

ProtoNet protein and cluster: P23527

UniProtKB/Swiss-Prot: H2B1O_HUMAN, P23527

Similarity: Belongs to the histone H2B family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: H2B1O_HUMAN, P23527

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to

the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of

post-translational modifications of histones, also called histone code, and nucleosome remodeling

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2BO
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2BO

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	1768865
GO:0046982	protein heterodimerization activity	IEA	--

HIST1H2BO for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for HIST1H2BO:

Increased Salmonella enterica

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Meiotic Synapsis

Meiotic Synapsis	1.00	Packaging Of Telomere Ends	0.54
Telomere clustering at the nuclear membrane	0.82	Telomere Maintenance	0.38
Meiosis	0.70	Meiotic Recombination	0.32
Chromosome Maintenance	0.56

RSF Complex Binds the Centromere.

	RSF Complex Binds the Centromere.	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere	1.00
	Nucleosome assembly	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere.	0.96

Signal transduction Activin A signaling regulation

	Signal transduction Activin A signaling regulation	1.00			Histone modification	0.31
	Signal transduction_Activin A signaling regulation	0.96

Formation of Meiotic Holliday Junction

	Formation of Meiotic Holliday Junction	1.00			Formation of Meiotic Single-stranded DNA Invasion Complex	0.83
	Formation of Meiotic Heteroduplex	0.83

Disease

Disease

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for HIST1H2BO

	Histone modification
	Signal transduction Activin A signaling regulation

1 GeneGo (Thomson Reuters) Pathway for HIST1H2BO

Signal transduction Activin A signaling regulation

5/17 Reactome Pathways for HIST1H2BO (see all 17)

	Telomere Maintenance
	Nucleosome assembly
	Cell Cycle
	RSF Complex Binds the Centromere.
	Disease

1 Kegg Pathway (Kegg details for HIST1H2BO):

Systemic lupus erythematosus

HIST1H2BO for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HIST1H2BO

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

4 Interacting proteins for HIST1H2BO (P23527³ ENSP00000303408⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AIRE	O43918³	I2D: score=1
ARRB1	P49407³	I2D: score=1
ARRB2	P32121³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	NAS	1768865

HIST1H2BO for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HIST1H2BO
Search CenterWatch for drugs/clinical trials and news about HIST1H2BO / H2B1O

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HIST1H2BO gene:

NM_003527.4

Unigene Cluster for HIST1H2BO:

Histone cluster 1, H2bo

Hs.484991 [show with all ESTs]

Unigene Representative Sequence: BX647290

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000303806(uc003nkc.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BO

Additional cDNA sequence:

BC106720.2 BX647290.1

2 DOTS entries:

DT.100708407 DT.40292966

7 AceView cDNA sequences:

NM_012367 NM_003527 N68399 BX647290 R16107 R16006 N91195

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HIST1H2BO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

HIST1H2BO expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HIST1H2BO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIST1H2BO

SOURCE GeneReport for Unigene cluster: Hs.484991

SABiosciences Custom PCR Arrays for HIST1H2BO

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIST1H2BO gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC770188¹	histone H2B 1/2/3/4/6-like	89.42(n) 96.03(a)		770188 XM_001233226.2 XP_001233227.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 8)	--	95(a) 94(a) (see all 8)	many ↔ many many ↔ many (see all 8)	GL343252.1(1828391-1828771) GL343466.1(265902-266282)
zebrafish (Danio rerio)	Actinopterygii	hist2h2l¹	histone 2, H2, like	82.8(n) 93.65(a)		386920 NM_200117.1 NP_956411.1
fruit fly (Drosophila melanogaster)	Insecta	His2B:CG33872¹	CG33872-PA	72.99(n) 87.93(a)		3771809 NM_001032204.1 NP_001027375.1
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AEL002W¹	AEL002Wp	65.8(n) 75(a)		4621058 NM_210213.1 NP_984859.1

ENSEMBL Gene Tree for HIST1H2BO (if available)
TreeFam Gene Tree for HIST1H2BO (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HIST1H2BO gene

HIST1H2BH¹ ² HIST3H2BB² HIST1H2BI² HIST1H2BK² HIST1H2BD² HIST1H2BG² HIST1H2BC² HIST2H2BF²

HIST1H2BL² HIST1H2BE² HIST1H2BJ² HIST1H2BB² HIST1H2BF² HIST2H2BE²

18/22 SIMAP similar genes for HIST1H2BO using alignment to 1 protein entry: H2B1O_HUMAN(see all similar genes):

HIST1H2BB HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH

HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BM HIST1H2BN HIST2H2BE

HIST2H2BF HIST3H2BB HIST1H2BC H2BFS HIST1H2BL HIST2H2BC

HIST1H2BO for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HIST1H2BO
PGOHUM00000243517

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200970^1,2	C,F,A,H,	--	27859300(-)	`TAGAGA/GATGTG`	2	--	us2k¹		12		NA NS WA	1548
rs150149871^1,2		--	27859301(+)	`ACATTC/GTCTAA`	2	--	us2k¹		0	--	--	--	--
rs147818744^1,2		--	27859430(+)	`AATGGC/TTGATT`	2	--	us2k¹		0	--	--	--	--
rs200969^1,2	C,F,A,H,	--	27859453(-)	`GCAATA/GATTTA`	2	--	us2k¹ tfbs³		27		EA NA NS WA CSA	2659
rs180793875^1,2		--	27859500(+)	`GTCAGC/TGATTA`	2	--	us2k¹		0	--	--	--	--
rs111369286^1,2		--	27859503(+)	`AGTGAC/TTAGAT`	2	--	us2k¹		1		CSA	2
rs200968^1,2	C,F,A,H,	--	27859568(-)	`GATCAA/GCTAAA`	2	--	us2k¹		25		NS EA NA WA	2846
rs186083796^1,2		--	27859774(+)	`TCTCAA/CATTCC`	2	--	us2k¹		0	--	--	--	--
rs9461419^1,2	H,	--	27859824(+)	`ACAGGC/GGAGGG`	2	--	us2k¹		6		NS EA WA NA	622
rs146954939^1,2		--	27859841(+)	`GCCTGC/GTATTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HIST1H2BO (27861203 - 27861669 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIST1H2BO: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HIST1H2BO for disorders           About GeneDecksing

OMIM gene information: 602808    OMIM disorders: --

3 diseases for HIST1H2BO:    About MalaCards

systemic lupus erythematosus lupus erythematosus immunodeficiency

Export disorders for HIST1H2BO gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HIST1H2BO gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with HIST1H2BO)

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The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F....Maltais L.J. (2002)
A novel divergently transcribed human histone H2A/H2B gene pair. (PubMed id 1768865)^{1, 2, 3} Dobner T.... Lipp M. (1991)
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)^{1, 2} Pavri R....Reinberg D. (2006)
Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)^{1, 2} Beck H.C.... Jensen O.N. (2006)
Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)^{1, 2} Golebiowski F. and Kasprzak K.S. (2005)
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)^{1, 2} Zhu B.... Reinberg D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)^{1, 2} Cheung W.L.... Allis C.D. (2003)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8348	HGNC: 4758	AceView: HIST1H2BOandOR2B6	Ensembl:ENSG00000196331	euGenes: HUgn8348
ECgene: HIST1H2BO	Kegg: 8348	H-InvDB: HIST1H2BO

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HIST1H2BO	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HIST1H2BO gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HIST1H2BO gene:
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