Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIST1H2BO Gene

protein-coding   GIFtS: 51
GCID: GC06P027861

Histone Cluster 1, H2bo

(Previous names: H2B histone family, member N, histone 1, H2bo)
(Previous symbol: H2BFN)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histone Cluster 1, H2bo1 2     H2B/n2 3
H2BFN1 2 3 5     H2B.22
H2B Histone Family, Member N1 2     dJ193B12.22
Histone 1, H2bo1 2     Histone H2B Type 1-O2
Histone H2B.22 3     H2BFH3
Histone H2B.N2 3     

External Ids:    HGNC: 47581   Entrez Gene: 83482   Ensembl: ENSG000001963317   OMIM: 6028085   UniProtKB: P235273   

Export aliases for HIST1H2BO gene to outside databases

Previous GC identifers: GC06P027919 GC06P027969 GC06P027668


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIST1H2BO Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BO Gene:
HIST1H2BO (histone cluster 1, H2bo) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST3H2BB.

UniProtKB/Swiss-Prot: H2B1O_HUMAN, P23527
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2BO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2BO gene promoter:
         GR   TBP   Egr-3   Pax-5   AML1a   GR-beta   Evi-1   E47   FOXO4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BO promoter sequence
   Search Chromatin IP Primers for HIST1H2BO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2BO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2BO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BO gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027861:  view genomic region     (about GC identifiers)

Start:
27,861,203 bp from pter      End:
27,861,669 bp from pter
Size:
467 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: H2B1O_HUMAN, P23527 (See protein sequence)
Recommended Name: Histone H2B type 1-O  
Size: 126 amino acids; 13906 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Miscellaneous: The mouse orthologous protein seems not to exist
Secondary accessions: Q3KPI7 Q8TCV6

Explore the universe of human proteins at neXtProt for HIST1H2BO: NX_P23527

Explore proteomics data for HIST1H2BO at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as
    a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a
    large set of exons1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys44, Lys47, Lys58, Lys109, Lys117, Lys121
  • Glycosylation2 at Ser113
  • Modification sites at PhosphoSitePlus

  • See HIST1H2BO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003518.2  
    ENSEMBL proteins: 
     ENSP00000303408  
    Reactome Protein details: P23527

    HIST1H2BO Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HIST1H2BO
    OriGene Protein Over-expression Lysate for HIST1H2BO
    OriGene MassSpec for HIST1H2BO
    OriGene Custom Protein Services for HIST1H2BO
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H2BO
    Novus Biologicals HIST1H2BO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H2BO

     
    Search eBioscience for Proteins for HIST1H2BO 

     
    antibodies-online proteins for HIST1H2BO (6 products) 

     
    Search antibodies-online for peptides for HIST1H2BO

    HIST1H2BO Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST1H2BO
    Abcam antibodies for HIST1H2BO
    Cloud-Clone Corp. Antibodies for HIST1H2BO
    Search ThermoFisher Antibodies for HIST1H2BO
    antibodies-online antibodies for HIST1H2BO (7 products) 

    HIST1H2BO Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIST1H2BO
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H2BO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H2BO
    Cloud-Clone Corp. CLIAs for HIST1H2BO
    Search eBioscience for ELISAs for HIST1H2BO 
    antibodies-online kits for HIST1H2BO (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P23527

    ProtoNet protein and cluster: P23527

    UniProtKB/Swiss-Prot: H2B1O_HUMAN, P23527
    Similarity: Belongs to the histone H2B family


    Find genes that share domains with HIST1H2BO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1O_HUMAN, P23527
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS1768865
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST1H2BO           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HIST1H2BO:
     Increased Salmonella enterica   Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HIST1H2BO

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST1H2BO:
    hsa-mir-296-3p (MIRT038469), hsa-mir-92b-5p (MIRT037793), hsa-mir-186-5p (MIRT045147), hsa-mir-34a-5p (MIRT025253), hsa-mir-320a (MIRT044788), hsa-mir-98-5p (MIRT027694)

    Block miRNA regulation of human, mouse, rat HIST1H2BO using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H2BO:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIST1H2BO
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2BO

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST1H2BO

    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H2BO (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H2BO (NM_003527)
    Sino Biological Human cDNA Clone for HIST1H2BO
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2BO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BO

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST1H2BO
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H2BO 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    H2B1O_HUMAN, P23527: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS1768865
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with HIST1H2BO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HIST1H2BO About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with HIST1H2BO           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BO
        Signal transduction Activin A signaling regulation


    Selected Reactome Pathways for HIST1H2BO (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H2BO):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2BO
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2BO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H2BO (P235273 ENSP000003034084) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIREO439183I2D: score=1 
    ARRB1P494073I2D: score=1 
    ARRB2P321213I2D: score=1 
    H2AFJENSP000003737304STRING: ENSP00000373730
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006334nucleosome assembly NAS1768865

    Find genes that share ontologies with HIST1H2BO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H2BO (H2B1O)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIST1H2BO gene: 
    NM_003527.4  

    Unigene Cluster for HIST1H2BO:

    Histone cluster 1, H2bo
    Hs.484991  [show with all ESTs]
    Unigene Representative Sequence: BX647290
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303806(uc003nkc.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIST1H2BO using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H2BO:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIST1H2BO
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2BO
    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H2BO (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H2BO (NM_003527)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2BO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BO
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HIST1H2BO
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2BO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BO
      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BO
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BO

    Additional mRNA sequence: 

    BC106720.2 BX647290.1 

    2 DOTS entries:

    DT.100708407  DT.40292966 

    7 AceView cDNA sequences:

    NM_003527 NM_012367 BX647290 N68399 R16006 R16107 N91195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIST1H2BO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H2BO Expression
    About this image

    HIST1H2BO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2BO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484991
        Custom PCR Arrays for HIST1H2BO
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HIST1H2BO
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2BO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BO
    QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BO
    QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H2BO gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2bp1 histone cluster 1, H2bp 90.21(n)
    96.03(a)
      319188  NM_178202.2  NP_835509.2 
    chicken
    (Gallus gallus)
    Aves HIST1H2B7L21 histone cluster 1, H2B-VII-like 2 (similar to human more 89.42(n)
    96.03(a)
      770188  XM_001233226.3  XP_001233227.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Histone H2B
    (see all 4)
    95(a)
    94(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343252.1(1828391-1828771)
    GL343466.1(297869-298249)
    zebrafish
    (Danio rerio)
    Actinopterygii hist2h2l1 histone 2, H2, like 82.8(n)
    93.65(a)
      386920  NM_200117.1  NP_956411.1 


    ENSEMBL Gene Tree for HIST1H2BO (if available)
    TreeFam Gene Tree for HIST1H2BO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIST1H2BO gene
    HIST3H2BB2  HIST1H2BN2  HIST1H2BI2  HIST1H2BK2  HIST1H2BG2  HIST1H2BD2  HIST1H2BC2  HIST1H2BH2  
    HIST2H2BF2  HIST1H2BL2  HIST1H2BE2  HIST1H2BJ2  HIST1H2BF2  HIST1H2BB2  HIST2H2BE2  HIST1H2BM2  
    Selected SIMAP similar genes for HIST1H2BO using alignment to 1 protein entry:     H2B1O_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH
    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BM    HIST1H2BN    HIST2H2BE
    HIST2H2BF    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    ABCF2

    Find genes that share paralogs with HIST1H2BO           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HIST1H2BO
    PGOHUM00000243517


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H2BO:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2BO
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2BO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602808    OMIM disorders: --


    Find genes that share disorders with HIST1H2BO           About GenesLikeMe


    Export disorders for HIST1H2BO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIST1H2BO gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with HIST1H2BO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. A novel divergently transcribed human histone H2A/H2B gene pair. (PubMed id 1768865)1, 2, 3 Dobner T.... Lipp M. (DNA Seq. 1991)
    3. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    4. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (Mol. Cell. Proteomics 2006)
    5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (Mol. Cell. Biochem. 2005)
    6. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)1, 2 Cheung W.L.... Allis C.D. (Cell 2003)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8348 HGNC: 4758 AceView: HIST1H2BOandOR2B6 Ensembl:ENSG00000196331 euGenes: HUgn8348
    ECgene: HIST1H2BO Kegg: 8348 H-InvDB: HIST1H2BO

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIST1H2BO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIST1H2BO gene:
    Search GeneIP for patents involving HIST1H2BO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HIST1H2BO  
     OriGene qPCR primer pairs and template standards for HIST1H2BO   OriGene Protein Over-expression Lysate for HIST1H2BO  
     OriGene MassSpec for HIST1H2BO   OriGene clones in human, mouse for HIST1H2BO  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2BO   OriGene Purified Protein for HIST1H2BO  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H2BO   OriGene Custom Protein Services for HIST1H2BO  

     
     
     Block miRNA regulation of human, mouse, rat HIST1H2BO using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIST1H2BO
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2BO Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2BO
     QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BO QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BO
     Custom PCR Arrays for HIST1H2BO Search Chromatin IP Primers for HIST1H2BO
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BO  Search GeneGlobe Interaction Network for HIST1H2BO
     Regulatory tfbs in HIST1H2BO promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H2BO GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H2BO
     GenScript Custom Assay Services for HIST1H2BO GenScript Custom overexpressing Cell Line Services for HIST1H2BO
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HIST1H2BO (H2B1O)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HIST1H2BO
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HIST1H2BO lysates
     Antibodies for HIST1H2BO
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H2BO
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIST1H2BO
     Antibodies for HIST1H2BO
     ELISAs for HIST1H2BO
     CLIAs for HIST1H2BO



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H2BO
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BO
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H2BO
     SwitchGear Promoter luciferase reporter plasmids for HIST1H2BO
     Search ThermoFisher Antibodies for HIST1H2BO
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BO
     Browse compounds at ApexBio
     Search Addgene for plasmids for HIST1H2BO
      Search eBioscience for proteins for HIST1H2BO
      Search eBioscience for elisas for HIST1H2BO
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HIST1H2BO
     antibodies-online antibodies for HIST1H2BO (7 products)
     antibodies-online kits for HIST1H2BO (3 products)
      Search antibodies-online for peptides for HIST1H2BO
     antibodies-online proteins for HIST1H2BO (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST1H2BO gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4