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Aliases for HIST1H2BO Gene

Aliases for HIST1H2BO Gene

  • Histone Cluster 1 H2B Family Member O 2 3 5
  • H2B Histone Family, Member N 2 3
  • Histone Cluster 1, H2bo 2 3
  • Histone 1, H2bo 2 3
  • Histone H2B.2 3 4
  • Histone H2B.N 3 4
  • H2BFN 3 4
  • H2B/N 3 4
  • Histone H2B Type 1-O 3
  • DJ193B12.2 3
  • H2BFH 4
  • H2B.2 3

External Ids for HIST1H2BO Gene

Previous HGNC Symbols for HIST1H2BO Gene

  • H2BFN

Previous GeneCards Identifiers for HIST1H2BO Gene

  • GC06P027919
  • GC06P027969
  • GC06P027861
  • GC06P027668

Summaries for HIST1H2BO Gene

Entrez Gene Summary for HIST1H2BO Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BO Gene

HIST1H2BO (Histone Cluster 1 H2B Family Member O) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and DNA Double Strand Break Response. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH.

UniProtKB/Swiss-Prot for HIST1H2BO Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2BO Gene

Additional gene information for HIST1H2BO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BO Gene

Genomics for HIST1H2BO Gene

Regulatory Elements for HIST1H2BO Gene

Enhancers for HIST1H2BO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H027834 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -56.1 -56133 6 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 RCOR2 NBN ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN12 ZSCAN9 HNRNPA1P1 HIST1H2BPS2 OR2B2 CD83P1 LOC442172
GH06H027821 1 ENCODE 11.2 -69.5 -69520 4 HDGF HNRNPUL1 ATF1 FOXA2 ARNT ARID4B SIN3A YY1 ELK1 ZNF207 ZKSCAN4 ZSCAN9 ZKSCAN8 ZSCAN12 ZKSCAN3 HIST1H3J HIST1H1B HIST1H2BO HIST1H3I HIST1H4L
GH06H027887 1.8 FANTOM5 ENCODE dbSUPER 4.7 +0.1 56 11 ZFP64 DMAP1 YY1 ZNF143 NFYC SSRP1 ZNF610 RCOR2 NBN NR2C1 ZKSCAN4 ZKSCAN8 ZKSCAN3 ZSCAN9 ZNF603P ZSCAN12 ZSCAN26 HIST1H4K HIST1H3H HIST1H2BN
GH06H027805 2 FANTOM5 Ensembl ENCODE dbSUPER 2.5 -81.3 -81311 12 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZKSCAN8 ZNF603P ZSCAN12 ZKSCAN3 ZSCAN9 ZKSCAN4 ZSCAN26 ZNF192P1 HIST1H4K ZNF204P
GH06H027687 1.7 FANTOM5 Ensembl ENCODE 1.6 -205.4 -205444 1 HNRNPUL1 PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 ZNF207 ZNF143 FOS ZKSCAN8 ZKSCAN3 ZSCAN12 ZSCAN23 ZNF603P ZNF391 ZSCAN9 GUSBP2 ZKSCAN4 RNU6-471P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H2BO on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2BO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195186 -125 5801 ZFP64 DMAP1 YBX1 YY1 ZNF143 NFYC SSRP1 ZNF610 RCOR2 NR2C1

Genomic Location for HIST1H2BO Gene

Chromosome:
6
Start:
27,893,425 bp from pter
End:
27,893,891 bp from pter
Size:
467 bases
Orientation:
Plus strand

Genomic View for HIST1H2BO Gene

Genes around HIST1H2BO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2BO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2BO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BO Gene

Proteins for HIST1H2BO Gene

  • Protein details for HIST1H2BO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23527-H2B1O_HUMAN
    Recommended name:
    Histone H2B type 1-O
    Protein Accession:
    P23527
    Secondary Accessions:
    • Q3KPI7
    • Q8TCV6

    Protein attributes for HIST1H2BO Gene

    Size:
    126 amino acids
    Molecular mass:
    13906 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    Miscellaneous:
    • The mouse orthologous protein seems not to exist.

neXtProt entry for HIST1H2BO Gene

Post-translational modifications for HIST1H2BO Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at isoforms=121
  • Glycosylation at isoforms=113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BO Gene

Domains & Families for HIST1H2BO Gene

Gene Families for HIST1H2BO Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HIST1H2BO Gene

Suggested Antigen Peptide Sequences for HIST1H2BO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23527

UniProtKB/Swiss-Prot:

H2B1O_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BO: view

Function for HIST1H2BO Gene

Molecular function for HIST1H2BO Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H2BO Gene

Gene Ontology (GO) - Molecular Function for HIST1H2BO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,NAS 1768865
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BO: view
genes like me logo Genes that share phenotypes with HIST1H2BO: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HIST1H2BO
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BO Gene

Localization for HIST1H2BO Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BO Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H2BO gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HIST1H2BO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 1768865
GO:0005634 nucleus IDA,IEA 16319397
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HIST1H2BO: view

Pathways & Interactions for HIST1H2BO Gene

SuperPathways for HIST1H2BO Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H2BO: view

Interacting Proteins for HIST1H2BO Gene

Gene Ontology (GO) - Biological Process for HIST1H2BO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA,NAS 1768865
GO:0016567 protein ubiquitination TAS --
genes like me logo Genes that share ontologies with HIST1H2BO: view

No data available for SIGNOR curated interactions for HIST1H2BO Gene

Drugs & Compounds for HIST1H2BO Gene

No Compound Related Data Available

Transcripts for HIST1H2BO Gene

mRNA/cDNA for HIST1H2BO Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2BO Gene

Histone cluster 1, H2bo:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HIST1H2BO
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BO Gene

No ASD Table

Relevant External Links for HIST1H2BO Gene

GeneLoc Exon Structure for
HIST1H2BO
ECgene alternative splicing isoforms for
HIST1H2BO

Expression for HIST1H2BO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H2BO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BO Gene

This gene is overexpressed in Whole Blood (x13.8).

Protein differential expression in normal tissues from HIPED for HIST1H2BO Gene

This gene is overexpressed in Saliva (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H2BO Gene



Protein tissue co-expression partners for HIST1H2BO Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HIST1H2BO Gene:

HIST1H2BO

SOURCE GeneReport for Unigene cluster for HIST1H2BO Gene:

Hs.484991
genes like me logo Genes that share expression patterns with HIST1H2BO: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2BO Gene

Orthologs for HIST1H2BO Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H2BO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC462509 33
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia LOC483169 33
  • 93.39 (n)
rat
(Rattus norvegicus)
Mammalia Hist1h2bo 33
  • 90.48 (n)
mouse
(Mus musculus)
Mammalia Hist1h2bp 33 16
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia HIST2H2BE 33
  • 89.42 (n)
chicken
(Gallus gallus)
Aves HIST1H2B7L2 33
  • 89.42 (n)
zebrafish
(Danio rerio)
Actinopterygii hist2h2l 33
  • 82.8 (n)
Species where no ortholog for HIST1H2BO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H2BO Gene

ENSEMBL:
Gene Tree for HIST1H2BO (if available)
TreeFam:
Gene Tree for HIST1H2BO (if available)

Paralogs for HIST1H2BO Gene

Variants for HIST1H2BO Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BO Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000031105 -- 27,892,110(+) TCGCC(C/T)AGGCT upstream-variant-2KB
rs1000538626 -- 27,892,660(+) GATAG(C/G)TTTGG downstream-variant-500B, upstream-variant-2KB
rs1000653439 -- 27,892,474(+) AACCA(-/C)CGCGC downstream-variant-500B, upstream-variant-2KB
rs1001722973 -- 27,891,963(+) GGAGT(A/G)CAGTG upstream-variant-2KB
rs1001775135 -- 27,892,177(+) ATTCT(C/G)CTGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BO Gene

Variant ID Type Subtype PubMed ID
nsv601208 CNV loss 21841781
nsv601209 CNV loss 21841781
nsv981121 CNV duplication 23825009

Variation tolerance for HIST1H2BO Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2BO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H2BO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BO Gene

Disorders for HIST1H2BO Gene

Relevant External Links for HIST1H2BO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2BO

No disorders were found for HIST1H2BO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BO Gene

Publications for HIST1H2BO Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 60
  2. A novel divergently transcribed human histone H2A/H2B gene pair. (PMID: 1768865) Dobner T … Lipp M (DNA sequence : the journal of DNA sequencing and mapping 1991) 2 3 4 60
  3. Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck HC … Jensen ON (Molecular & cellular proteomics : MCP 2006) 3 4 60
  4. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R … Reinberg D (Cell 2006) 3 4 60
  5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F … Kasprzak KS (Molecular and cellular biochemistry 2005) 3 4 60

Products for HIST1H2BO Gene

Sources for HIST1H2BO Gene

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