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Aliases for HIST1H2BN Gene

Aliases for HIST1H2BN Gene

  • Histone Cluster 1, H2bn 2 3
  • H2BFD 3 4 6
  • H2B Histone Family, Member D 2 3
  • Histone 1, H2bn 2 3
  • Histone H2B.D 3 4
  • H2B/D 3 4
  • Histone H2B Type 1-N 3

External Ids for HIST1H2BN Gene

Previous HGNC Symbols for HIST1H2BN Gene

  • H2BFD

Previous GeneCards Identifiers for HIST1H2BN Gene

  • GC06P027864
  • GC06P027914
  • GC06P027913
  • GC06P027805
  • GC06P027614

Summaries for HIST1H2BN Gene

Entrez Gene Summary for HIST1H2BN Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2BN Gene

HIST1H2BN (Histone Cluster 1, H2bn) is a Protein Coding gene. Diseases associated with HIST1H2BN include hiv-1. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST2H2BE.

UniProtKB/Swiss-Prot for HIST1H2BN Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BN Gene

Genomics for HIST1H2BN Gene

Regulatory Elements for HIST1H2BN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST1H2BN Gene

Start:
27,837,760 bp from pter
End:
27,865,798 bp from pter
Size:
28,039 bases
Orientation:
Plus strand

Genomic View for HIST1H2BN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2BN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BN Gene

Proteins for HIST1H2BN Gene

  • Protein details for HIST1H2BN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99877-H2B1N_HUMAN
    Recommended name:
    Histone H2B type 1-N
    Protein Accession:
    Q99877
    Secondary Accessions:
    • B2R5L4
    • Q494S8
    • Q96FB7

    Protein attributes for HIST1H2BN Gene

    Size:
    126 amino acids
    Molecular mass:
    13922 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for HIST1H2BN Gene

Proteomics data for HIST1H2BN Gene at MOPED

Post-translational modifications for HIST1H2BN Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BN Gene

Domains for HIST1H2BN Gene

Gene Families for HIST1H2BN Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2BN Gene

Suggested Antigen Peptide Sequences for HIST1H2BN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99877

UniProtKB/Swiss-Prot:

H2B1N_HUMAN :
  • Q99877
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BN: view

Function for HIST1H2BN Gene

Molecular function for HIST1H2BN Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2BN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9439656
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BN: view
genes like me logo Genes that share phenotypes with HIST1H2BN: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HIST1H2BN Gene

Localization for HIST1H2BN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BN Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BN Gene COMPARTMENTS Subcellular localization image for HIST1H2BN gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 9439656
GO:0000788 nuclear nucleosome IBA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST1H2BN: view

Pathways for HIST1H2BN Gene

genes like me logo Genes that share pathways with HIST1H2BN: view

Pathways by source for HIST1H2BN Gene

1 BioSystems pathway for HIST1H2BN Gene
29 Reactome pathways for HIST1H2BN Gene
3 KEGG pathways for HIST1H2BN Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2BN Gene

Gene Ontology (GO) - Biological Process for HIST1H2BN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly NAS 9439656
genes like me logo Genes that share ontologies with HIST1H2BN: view

Transcripts for HIST1H2BN Gene

mRNA/cDNA for HIST1H2BN Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BN

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BN Gene

No ASD Table

Relevant External Links for HIST1H2BN Gene

GeneLoc Exon Structure for
HIST1H2BN
ECgene alternative splicing isoforms for
HIST1H2BN

Expression for HIST1H2BN Gene

mRNA expression in normal human tissues for HIST1H2BN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2BN Gene

SOURCE GeneReport for Unigene cluster for HIST1H2BN Gene Hs.673851

genes like me logo Genes that share expressions with HIST1H2BN: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST1H2BN Gene

Orthologs for HIST1H2BN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H2BN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BN 36
  • 100 (a)
OneToOne
LOC462508 35
  • 99.47 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia H2B 36
  • 100 (a)
OneToOne
LOC787269 35
  • 91.53 (n)
  • 99.21 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
ManyToMany
LOC478743 35
  • 93.65 (n)
  • 99.21 (a)
mouse
(Mus musculus)
Mammalia Hist1h2bm 35
  • 93.39 (n)
  • 99.21 (a)
Hist1h2bn 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hist1h2bd 35
  • 90.48 (n)
  • 98.41 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12831 35
Species with no ortholog for HIST1H2BN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2BN Gene

ENSEMBL:
Gene Tree for HIST1H2BN (if available)
TreeFam:
Gene Tree for HIST1H2BN (if available)

Paralogs for HIST1H2BN Gene

genes like me logo Genes that share paralogs with HIST1H2BN: view

Variants for HIST1H2BN Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs201004 -- 27,837,156(-) ctccc(A/G)ccccc upstream-variant-2KB
rs71546575 -- 27,837,244(+) GTGTG(-/TA)TGTTT upstream-variant-2KB
rs73386609 -- 27,837,005(+) GGTCC(C/T)TCCGC upstream-variant-2KB
rs141844723 -- 27,837,166(+) GAGAG(C/G)GGACT upstream-variant-2KB
rs143710027 -- 27,836,712(+) ATCTC(C/T)GGAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BN Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294

Relevant External Links for HIST1H2BN Gene

HapMap Linkage Disequilibrium report
HIST1H2BN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BN Gene

Disorders for HIST1H2BN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HIST1H2BN Gene including...

Search for HIST1H2BN Gene in MalaCards »

Relevant External Links for HIST1H2BN

Genetic Association Database (GAD)
HIST1H2BN
genes like me logo Genes that share disorders with HIST1H2BN: view

No data available for UniProtKB/Swiss-Prot for HIST1H2BN Gene

Publications for HIST1H2BN Gene

  1. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HIST1H2BN Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2BN
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BN
  • Block miRNA regulation of HIST1H2BN using miScript Target Protectors

Sources for HIST1H2BN Gene

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