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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2BM Gene

protein-coding   GIFtS: 52
GCID: GC06P027782

histone cluster 1, H2bm

(Previous names: H2B histone family, member E, histone 1, H2bm )
(Previous symbol: H2BFE)
 Explore 4 diseases affiliated with
HIST1H2BM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H2BM    

Aliases
for HIST1H2BM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H2bm1 2     H2B Histone Family, Member E1 2
H2BFE1 2 3 5     Histone 1, H2bm1 2
H2B/E1     Histone H2B.E2 3
DJ160A22.31     Histone H2B Type 1-M2

External Ids:    HGNC: 47501   Entrez Gene: 83422   Ensembl: ENSG000001963747   OMIM: 6028025   UniProtKB: Q998793   

Export aliases for HIST1H2BM gene to outside databases

Previous GC identifers: GC06P027841 GC06P027892 GC06P027893 GC06P027894 GC06P027591


Summaries
for HIST1H2BM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H2BM:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome
6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2B1M_HUMAN, Q99879
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BM


Genomic Views
for HIST1H2BM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2BM gene promoter:
         NF-YA   AP-4   CUTL1   Egr-4   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H2BM promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2BM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2BM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BM gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027782:  view genomic region     (about GC identifiers)

Start:
 27,782,822 bp from pter      End:
 27,783,267 bp from pter
Size:
 446 bases      Orientation:
 plus strand

Proteins
for HIST1H2BM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2B1M_HUMAN, Q99879 (See protein sequence)
Recommended Name: Histone H2B type 1-M  
Size: 126 amino acids; 13989 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Secondary accessions: Q6NWQ3

Explore the universe of human proteins at neXtProt for HIST1H2BM: NX_Q99879

Post-translational modifications:

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79'
    • (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly,
    monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional
    activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively
    with the FACT dimer to stimulate elongation by RNA polymerase II1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    • Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation.
    Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic
    hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose,
    • and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99879

    • HIST1H2BM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003512.1  
    ENSEMBL proteins: 
     ENSP00000352442  
    Reactome Protein details: Q99879
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HIST1H2BM
    OriGene Protein Over-expression Lysate: HIST1H2BM
    OriGene Custom Protein Services for HIST1H2BM 
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    Novus Biologicals HIST1H2BM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H2BM

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS9439656
    GO:0005634nucleus IEA--


    HIST1H2BM for ontologies           About GeneDecksing



    HIST1H2BM Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H2BM
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    Uscn Antibodies for HIST1H2BM
    Search ThermoFisher Antibodies for HIST1H2BM

    Assay Products for HIST1H2BM: 
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    Uscn ELISAs and CLIAs for HIST1H2BM

    Protein Domains /
    Families
    for HIST1H2BM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H2BM for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q99879

    ProtoNet protein and cluster: Q99879

    UniProtKB/Swiss-Prot: H2B1M_HUMAN, Q99879
    Similarity: Belongs to the histone H2B family


    Function
    for HIST1H2BM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2B1M_HUMAN, Q99879
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HIST1H2BM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2BM
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H2BM:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2BM (see all 4)
    OriGene shRNA RFP: HIST1H2BM
    OriGene siRNA: HIST1H2BM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2BM

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2BM (see all 2)
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    Cell Line
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    Search LifeMap BioReagents cell lines for HIST1H2BM

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2BM

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS9439656
    GO:0046982protein heterodimerization activity IEA--


    HIST1H2BM for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIST1H2BM:
     Wnt reporter downregulated 


    Pathways & Interactions
    for HIST1H2BM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Packaging Of Telomere Ends0.54
    		Telomere clustering at the nuclear membrane0.82
    		Telomere Maintenance0.38
    		Meiosis0.70
    		Meiotic Recombination0.32
    		Chromosome Maintenance0.56
    2RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    3Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    4Formation of Meiotic Holliday Junction
    		Formation of Meiotic Holliday Junction1.00
    		Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    		Formation of Meiotic Heteroduplex0.83
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2BM
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BM
        Signal transduction Activin A signaling regulation

    5/17        Reactome Pathways for HIST1H2BM (see all 17)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Disease


    1         Kegg Pathway  (Kegg details for HIST1H2BM):
        Systemic lupus erythematosus


    HIST1H2BM for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2BM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for HIST1H2BM (Q998793 ENSP000003524424) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    NOP56O005673, ENSP000003705894I2D: score=1 STRING: ENSP00000370589
    HIST1H3DENSP000003669994STRING: ENSP00000366999
    HIST1H4BENSP000003665814STRING: ENSP00000366581
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS9439656


    HIST1H2BM for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H2BM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2BM
    Search CenterWatch for drugs/clinical trials and news about HIST1H2BM / H2B1M 

    Transcripts
    for HIST1H2BM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H2BM gene: 
    NM_003521.2  

    Unigene Cluster for HIST1H2BM:

    Histone cluster 1, H2bm
    Hs.182432  [show with all ESTs]
    Unigene Representative Sequence: BM752802
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000359465(uc003njo.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2BM
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H2BM:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2BM (see all 4)
    OriGene shRNA RFP: HIST1H2BM
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2BM
    Clone
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    GenScript: all cDNA clones in your preferred vector: HIST1H2BM (NM_003521)
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    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H2BM
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BM

    Additional cDNA sequence: 

    BC066244.1 BC067485.1 BC067486.1 BC067487.1 BC067488.1 BC067489.1 

    1 DOTS entry:

    DT.101984517 

    20 AceView cDNA sequences:

    BC067486 NM_003521 BC067485 CF272056 BC067487 BC067489 BC066244 BC067488 
    CF272065 CF272063 CF272069 BM752802 CF272059 CF272054 CF272062 CF272071 
    CF272068 CF272057 CF272055 CF272072 

    GeneLoc Exon Structure


    Expression
    for HIST1H2BM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2BM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST1H2BM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Adult human kidney epithelial cells (Primary Cell)Kidney
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST1H2BM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2BM

    SOURCE GeneReport for Unigene cluster: Hs.182432
        SABiosciences Custom PCR Arrays for HIST1H2BM
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2BM

    Orthologs
    for HIST1H2BM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H2BM gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H2B1_CHICK6
    H2B1_CHICK6
    (see all 8)    		 Histone H2B 1/2/3/4/6
    (see all 8)    		 93(a)
    93(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 1(49976548-49976928)
    1(50028609-50028989)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 8)    		 --
    		 93(a)
    92(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 GL343466.1(297869-298249)
    GL343466.1(314932-315312)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1140466
    zgc:1140466
    (see all 33)    		 zgc:114046
    (see all 33)    		 90(a)
    90(a)
    (see all 33)    		 possible ortholog
    possible ortholog
    (see all 33)    		 7(76851937-76852311)
    7(76828836-76830255)


    ENSEMBL Gene Tree for HIST1H2BM (if available)
    TreeFam Gene Tree for HIST1H2BM (if available) 

    Paralogs
    for HIST1H2BM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2BM gene
    HIST1H2BA2  H2BFM2  H2BFWT2  
    18/22 SIMAP similar genes for HIST1H2BM using alignment to 2 protein entries:     H2B1M_HUMAN (see all proteins) (see all similar genes):
    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH    HIST1H2BI
    HIST1H2BJ    HIST1H2BK    HIST1H2BO    HIST2H2BE    HIST2H2BF    HIST1H2BC
    H2BFS    HIST1H2BB    HIST1H2BL    HIST1H2BN    HIST3H2BB    HIST2H2BC

    HIST1H2BM for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for HIST1H2BM (see all 8)
    PGOHUM00000244266 PGOHUM00000244472 PGOHUM00000244880 PGOHUM00000244995 PGOHUM00000239182


    Genomic Variants
    for HIST1H2BM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    8 NCBI SNPs in HIST1H2BM are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs69119121,2
    		C,--27780830(+) ggctgC/Tgttgg 1 -- us2k10--------
    rs1427324061,2
    		--27780831(+) GCTGCA/GTTGGG 1 -- us2k10--------
    rs586773211,2
    		C,--27780978(+) TCACTA/CTTCTC 1 -- us2k13Minor allele frequency- C:0.05WA CSA 121
    rs1114408951,2
    		F--27780991(+) AATAGC/TCTTTG 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1904380841,2
    		--27781090(+) CCATCA/GAACAT 1 -- us2k10--------
    rs1444601631,2
    		--27781306(+) ACACTA/GACATA 1 -- us2k10--------
    rs1822062241,2
    		--27781460(+) ATACAC/TTGGTA 1 -- us2k10--------
    rs764421401,2
    		----27780932(+) CAAAAC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for HIST1H2BM (27782822 - 27783267 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H2BM: --

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    Disorders / Diseases
    for HIST1H2BM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H2BM for disorders           About GeneDecksing

    OMIM gene information: 602802    OMIM disorders: --

    4 diseases for HIST1H2BM:    About MalaCards
    treacher collins syndrome    systemic lupus erythematosus    lupus erythematosus    immunodeficiency


    Export disorders for HIST1H2BM gene to outside databases

    Publications
    for HIST1H2BM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2BM gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with HIST1H2BM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    4. Gene-specific characterization of human histone H2B by electron capture dissociation. (PubMed id 16457587)1, 2 Siuti N.... Pesavento J.J. (2006)
    5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
    6. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)1, 2 Cheung W.L.... Allis C.D. (2003)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    External Searches for HIST1H2BM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H2BM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8342 HGNC: 4750 AceView: HIST1H2BM Ensembl:ENSG00000196374 euGenes: HUgn8342
    ECgene: HIST1H2BM Kegg: 8342 H-InvDB: HIST1H2BM

    Other Databases showing HIST1H2BM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H2BM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2BM Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H2BM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H2BM gene:
    Search GeneIP for patents involving HIST1H2BM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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