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Aliases for HIST1H2BM Gene

Aliases for HIST1H2BM Gene

  • Histone Cluster 1, H2bm 2 3
  • H2BFE 3 4 6
  • H2B Histone Family, Member E 2 3
  • Histone 1, H2bm 2 3
  • Histone H2B.E 3 4
  • H2B/E 3 4
  • Histone H2B Type 1-M 3
  • DJ160A22.3 3

External Ids for HIST1H2BM Gene

Previous HGNC Symbols for HIST1H2BM Gene

  • H2BFE

Previous GeneCards Identifiers for HIST1H2BM Gene

  • GC06P027841
  • GC06P027892
  • GC06P027893
  • GC06P027894
  • GC06P027782
  • GC06P027591

Summaries for HIST1H2BM Gene

Entrez Gene Summary for HIST1H2BM Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2BM Gene

HIST1H2BM (Histone Cluster 1, H2bm) is a Protein Coding gene. Diseases associated with HIST1H2BM include hiv-1 and colorectal cancer. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for HIST1H2BM Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BM Gene

Genomics for HIST1H2BM Gene

Regulatory Elements for HIST1H2BM Gene

Genomic Location for HIST1H2BM Gene

Start:
27,815,044 bp from pter
End:
27,815,489 bp from pter
Size:
446 bases
Orientation:
Plus strand

Genomic View for HIST1H2BM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2BM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BM Gene

Proteins for HIST1H2BM Gene

  • Protein details for HIST1H2BM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99879-H2B1M_HUMAN
    Recommended name:
    Histone H2B type 1-M
    Protein Accession:
    Q99879
    Secondary Accessions:
    • Q6NWQ3

    Protein attributes for HIST1H2BM Gene

    Size:
    126 amino acids
    Molecular mass:
    13989 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for HIST1H2BM Gene

Proteomics data for HIST1H2BM Gene at MOPED

Post-translational modifications for HIST1H2BM Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BM Gene

Domains for HIST1H2BM Gene

Gene Families for HIST1H2BM Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2BM Gene

Suggested Antigen Peptide Sequences for HIST1H2BM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99879

UniProtKB/Swiss-Prot:

H2B1M_HUMAN :
  • Q99879
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BM: view

Function for HIST1H2BM Gene

Molecular function for HIST1H2BM Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2BM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9439656
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BM: view

Phenotypes for HIST1H2BM Gene

GenomeRNAi human phenotypes for HIST1H2BM:
genes like me logo Genes that share phenotypes with HIST1H2BM: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HIST1H2BM Gene

Localization for HIST1H2BM Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BM Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BM Gene COMPARTMENTS Subcellular localization image for HIST1H2BM gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 9439656
GO:0000788 nuclear nucleosome IBA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST1H2BM: view

Pathways for HIST1H2BM Gene

genes like me logo Genes that share pathways with HIST1H2BM: view

Pathways by source for HIST1H2BM Gene

29 Reactome pathways for HIST1H2BM Gene
3 KEGG pathways for HIST1H2BM Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2BM Gene

Interacting Proteins for HIST1H2BM Gene

Selected Interacting proteins: Q99879-H2B1M_HUMAN for HIST1H2BM Gene via I2D

Gene Ontology (GO) - Biological Process for HIST1H2BM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly NAS 9439656
genes like me logo Genes that share ontologies with HIST1H2BM: view

Transcripts for HIST1H2BM Gene

mRNA/cDNA for HIST1H2BM Gene

(20) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2BM Gene

Histone cluster 1, H2bm:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BM

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST1H2BM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BM Gene

No ASD Table

Relevant External Links for HIST1H2BM Gene

GeneLoc Exon Structure for
HIST1H2BM
ECgene alternative splicing isoforms for
HIST1H2BM

Expression for HIST1H2BM Gene

mRNA expression in normal human tissues for HIST1H2BM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BM Gene

This gene is overexpressed in Whole Blood (7.9), Brain - Spinal cord (cervical c-1) (4.8), and Vagina (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HIST1H2BM Gene

SOURCE GeneReport for Unigene cluster for HIST1H2BM Gene Hs.182432

genes like me logo Genes that share expressions with HIST1H2BM: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BM Gene

Orthologs for HIST1H2BM Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2BM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748505 35
  • 85.71 (n)
  • 96.83 (a)
cow
(Bos Taurus)
Mammalia HIST1H2BB 35
  • 84.39 (n)
  • 96.03 (a)
dog
(Canis familiaris)
Mammalia LOC100683643 35
  • 87.6 (n)
  • 94.21 (a)
mouse
(Mus musculus)
Mammalia Hist1h2bm 16
Hist1h2bn 35
  • 88.36 (n)
  • 96.03 (a)
Species with no ortholog for HIST1H2BM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2BM Gene

ENSEMBL:
Gene Tree for HIST1H2BM (if available)
TreeFam:
Gene Tree for HIST1H2BM (if available)

Paralogs for HIST1H2BM Gene

genes like me logo Genes that share paralogs with HIST1H2BM: view

No data available for Paralogs for HIST1H2BM Gene

Variants for HIST1H2BM Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BM Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6911912 -- 27,813,052(+) ggctg(C/T)gttgg upstream-variant-2KB
rs58677321 -- 27,813,200(+) TCACT(A/C)TTCTC upstream-variant-2KB
rs76442140 -- 27,813,154(+) CAAAA(A/C)AAAAA upstream-variant-2KB
rs111440895 -- 27,813,213(+) AATAG(C/T)CTTTG upstream-variant-2KB
rs142732406 -- 27,813,053(+) GCTGC(A/G)TTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BM Gene

Variant ID Type Subtype PubMed ID
nsv830618 CNV Gain 17160897
nsv883512 CNV Gain 21882294

Relevant External Links for HIST1H2BM Gene

HapMap Linkage Disequilibrium report
HIST1H2BM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BM Gene

Disorders for HIST1H2BM Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HIST1H2BM Gene including...

Search for HIST1H2BM Gene in MalaCards »
genes like me logo Genes that share disorders with HIST1H2BM: view

No data available for UniProtKB/Swiss-Prot for HIST1H2BM Gene

Publications for HIST1H2BM Gene

  1. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4

Products for HIST1H2BM Gene

Sources for HIST1H2BM Gene

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